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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RANBP9 Gene

protein-coding   GIFtS: 61
GCID: GC06M013621

RAN Binding Protein 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAN Binding Protein 91 2     RanBP72 3
RANBPM2 3 5     Novel Centrosomal Protein RanBPM2
Ran Binding Protein In The Microtubule Organizing Center1 2     Ran Binding Protein, Centrosomal2
Ran-Binding Protein M2 3     Ran-Binding Protein 92
BPM-L2 3     RanBP93
BPM902 3     RanBPM3

External Ids:    HGNC: 137271   Entrez Gene: 100482   Ensembl: ENSG000000100177   OMIM: 6038545   UniProtKB: Q96S593   

Export aliases for RANBP9 gene to outside databases

Previous GC identifers: GC06M013679 GC06M013730 GC06M013729 GC06M013566


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RANBP9 Gene:
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is
essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this
gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain
interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. (provided by RefSeq, Jul 2008)

GeneCards Summary for RANBP9 Gene: 
RANBP9 (RAN binding protein 9) is a protein-coding gene. Diseases associated with RANBP9 include pilocytic astrocytoma, and lissencephaly, and among its related super-pathways are Axon guidance and Development HGF signaling pathway. GO annotations related to this gene include enzyme binding and Ran GTPase binding. An important paralog of this gene is SPRYD3.

UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
Function: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be
involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and
activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as
dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation.
Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic
activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity)

Gene Wiki entry for RANBP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RANBP9 gene promoter:
         HFH-3   TBP   FosB   CUTL1   E4BP4   Evi-1   FOXI1   TFIID   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP9 promoter sequence
   Search SABiosciences Chromatin IP Primers for RANBP9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANBP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23   Ensembl cytogenetic band:  6p23   HGNC cytogenetic band: 6p23

RANBP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M013621:  view genomic region     (about GC identifiers)

Start:
13,621,730 bp from pter      End:
13,711,796 bp from pter
Size:
90,067 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59 (See protein sequence)
Recommended Name: Ran-binding protein 9  
Size: 729 amino acids; 77847 Da
Subunit: Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1,
S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B.
Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1
and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex
consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10
Subcellular location: Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is
associated with the plasma membrane
Caution: According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in
microtubule assembly, but other authors infirmed these results in (PubMed:11470507)
Sequence caution: Sequence=AAH19886.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH52781.1; Type=Frameshift; Positions=13, 30, 34; Sequence=AAK15469.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAA23216.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A0PJA2 O94764 Q6P3T7 Q7LBR2 Q7Z7F9
Alternative splicing: 2 isoforms:  Q96S59-1   Q96S59-2   

Explore the universe of human proteins at neXtProt for RANBP9: NX_Q96S59

Explore proteomics data for RANBP9 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C)
  • UniProtKB: Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be
    deubiquitinated by USP11
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96S59

  • RANBP9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RANBP9 Protein Expression
    REFSEQ proteins: NP_005484.2  
    ENSEMBL proteins: 
     ENSP00000011619   ENSP00000438162  
    Reactome Protein details: Q96S59
    Human Recombinant Protein Products for RANBP9: 
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    Cloud-Clone Corp. Proteins for RANBP9 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12220523
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005875microtubule associated complex TAS9817760

    RANBP9 for ontologies           About GeneDecksing



    RANBP9 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RANBP9 
    Cloud-Clone Corp. CLIAs for RANBP9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/9 InterPro protein domains (see all 9):
     IPR001870 B30.2/SPRY
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA
     IPR013720 LisH_dimerisation_subgr

    Graphical View of Domain Structure for InterPro Entry Q96S59

    ProtoNet protein and cluster: Q96S59

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
    Domain: The SPRY domain mediates the interaction with MET, AR, and CDC2L1
    Similarity: Belongs to the RANBP9/10 family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    RANBP9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RANB9_HUMAN, Q96S59
    Function: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be
    involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and
    activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as
    dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation.
    Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic
    activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12220523
    GO:0008536Ran GTPase binding IEA--
    GO:0019899enzyme binding IPI17087506
         
    RANBP9 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RANBP9:
     Decreased influenza A/WSN/33 r  Increased cell death in breast  Increased cell number in G1, s  Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ranbp9):
     cellular  endocrine/exocrine gland  growth/size  mortality/aging  reproductive system 

    RANBP9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RANBP9 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RANBP9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RANBP9 

    miRNA
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    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidRANBP9 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RANBP9 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    2Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.31
    3BDNF signaling pathway
    BDNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RANBP9
        BDNF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    3        Reactome Pathways for RANBP9
        L1CAM interactions
    Developmental Biology
    Axon guidance



    RANBP9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RANBP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/122 Interacting proteins for RANBP9 (Q96S591, 2, 3 ENSP000000116194) via UniProtKB, MINT, STRING, and/or I2D (see all 122)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085812, 3, ENSP000003172724MINT-18300 MINT-18299 MINT-18298 I2D: score=3 STRING: ENSP00000317272
    DYRK1BQ9Y4631, 3, ENSP000003127894EBI-636085,EBI-634187 I2D: score=5 STRING: ENSP00000312789
    DISC1Q9NRI51, 3, ENSP000003555964EBI-636085,EBI-529989 I2D: score=4 STRING: ENSP00000355596
    S100A7P311511, 3, ENSP000003577114EBI-636085,EBI-357520 I2D: score=4 STRING: ENSP00000357711
    SMAD2Q157962, 3, ENSP000002621604MINT-61580 I2D: score=3 STRING: ENSP00000262160
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9817760
    GO:0007020microtubule nucleation NAS12220523
    GO:0007411axon guidance TAS--

    RANBP9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RANBP9 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RANBP9 (RANB9)

    1 HMDB Compound for RANBP9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for RANBP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 3.55 3 12147692 (2)

    Search CenterWatch for drugs/clinical trials and news about RANBP9 / RANB9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RANBP9 gene: 
    NM_005493.2  

    Unigene Cluster for RANBP9:

    RAN binding protein 9
    Hs.708182  [show with all ESTs]
    Unigene Representative Sequence: BC052781
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000011619(uc003nba.3 uc003nbb.3) ENST00000469916 ENST00000539980


    miRNA
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    8/79 QIAGEN miScript miRNA Assays for microRNAs that regulate RANBP9 (see all 79):
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    Additional mRNA sequence: 

    AB008515.1 AB055311.1 AF064606.1 AF306510.1 AK313334.1 BC019886.1 BC052781.1 BC053374.1 
    BC063849.1 

    22 DOTS entries:

    DT.75134356  DT.97860381  DT.100832839  DT.87016836  DT.87077259  DT.302777  DT.121393585  DT.121393601 
    DT.121393628  DT.40197238  DT.99938447  DT.100686896  DT.121393638  DT.40130589  DT.121393612  DT.95176782 
    DT.100718611  DT.100832837  DT.75100356  DT.95195419  DT.97768314  DT.97799072 

    24/255 AceView cDNA sequences (see all 255):

    AA693668 BE019086 BQ129227 AI521097 BC063849 AA680140 BU620094 BU165665 
    AI076142 BQ227003 AA443348 AI499045 AI497974 AA737575 AI654598 AU280717 
    AA877727 AA485130 Z41285 BQ010353 BM021493 BC019886 AA954811 NM_005493 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RANBP9 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^
    SP1:        -     -     -                 -     -     -                 -                 -                                                                     
    SP2:                                                                    -                 -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                    -                 -     -                                                               

    ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:              -                           
    SP5:                                          


    ECgene alternative splicing isoforms for RANBP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RANBP9 expression in normal human tissues (normalized intensities)      RANBP9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACGGTGT
    RANBP9 Expression
    About this image


    RANBP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   
     
     Testis (Reproductive System)

    See RANBP9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RANBP9

    SOURCE GeneReport for Unigene cluster: Hs.708182

    UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
    Tissue specificity: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest
    levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular
    layer of cerebellum and the Purkinje cells

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RANBP9 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp91 , 5 RAN binding protein 91, 5 91.92(n)1
    95.63(a)1
      13 (21.60 cM)5
    567051  NM_019930.21  NP_064314.21 
     434026735 
    chicken
    (Gallus gallus)
    Aves RANBP91 RAN binding protein 9 83.9(n)
    92.2(a)
      420836  XM_418927.3  XP_418927.3 
    lizard
    (Anolis carolinensis)
    Reptilia RANBP96
    Uncharacterized protein
    88(a)
    1 ↔ 1
    4(57091947-57130816)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986772 hypothetical protein LOC398677 81.01(n)    AB018696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ranbp92 RAN binding protein 9 80.34(n)   266986  57059650 
    fruit fly
    (Drosophila melanogaster)
    Insecta RanBPM1 Ran-binding protein M 54.25(n)
    52.84(a)
      36102  NM_165770.2  NP_724932.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VID306
    Protein involved in proteasome-dependent catabolit...
    13(a)
    1 → many
    VII(69671-72547)


    ENSEMBL Gene Tree for RANBP9 (if available)
    TreeFam Gene Tree for RANBP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RANBP9 gene
    SPRYD32  RANBP102  
    1 SIMAP similar gene for RANBP9 using alignment to 2 protein entries:     RANB9_HUMAN (see all proteins):
    RANBP10

    RANBP9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1918 SNPs in RANBP9 are shown (see all 1918)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766455141,2
    F--13621698(+) TGCAAG/ATACCT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1462783391,2
    C--13621709(+) ATATA-/TTAAAC 1 -- ds50010--------
    rs1904454001,2
    --13621726(+) GACACC/TGTATC 1 -- ds50010--------
    rs1833462451,2
    --13621969(+) TTAAAC/TAGGAA 1 -- ut310--------
    rs1889560011,2
    --13622032(+) GGATTG/TTAAGT 1 -- ut310--------
    rs747801321,2
    C--13622132(+) ACTGTC/-CGGAT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1923342181,2
    C--13622553(+) GTTGAC/GTATAT 1 -- ut310--------
    rs1157199681,2
    C,F--13622567(+) ACAATA/GTAAGT 1 -- ut312Minor allele frequency- G:0.03NA EU 1443
    rs2011189741,2
    C--13622591(+) ATGCAC/TAGCTA 1 -- ut310--------
    rs1842856771,2
    C--13622613(+) CTTCCA/TCTGTG 2 E V mis10--------

    HapMap Linkage Disequilibrium report for RANBP9 (13621730 - 13711796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RANBP9:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674410CNV Deletion23128226
    esv2299523CNV Deletion18987734
    esv2669023CNV Deletion23128226
    dgv6435n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603854    OMIM disorders: --

    9 diseases for RANBP9:    About MalaCards
    pilocytic astrocytoma    lissencephaly    astrocytoma    mental retardation
    alzheimer's disease    schizophrenia    thyroiditis    breast cancer
    neuronitis


    RANBP9 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: RANBP9 (1 document)

    Export disorders for RANBP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RANBP9 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with RANBP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. (PubMed id 9817760)1, 2, 3, 9 Nakamura M.... Nishimoto T. (1998)
    2. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. (PubMed id 11470507)1, 2, 9 Nishitani H.... Nishimoto T. (2001)
    3. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. (PubMed id 14722085)1, 2, 9 Denti S.... Bianchi E. (2004)
    4. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PubMed id 12084015)1, 2, 9 Ideguchi H.... Ishigatsubo Y. (2002)
    5. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PubMed id 12147692)1, 2, 9 Wang D.... Wu G. (2002)
    6. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PubMed id 14511641)1, 2, 9 Mikolajczyk M.... Nelson M. (2003)
    7. The C-terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. (PubMed id 15381419)1, 2, 9 Menon R.P.... Pastore A. (2004)
    8. Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (PubMed id 15558019)1, 2 Kramer S.... Nakagawara A. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PubMed id 12559565)1, 2 Umeda M.... Nishimoto T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10048 HGNC: 13727 AceView: RANBP9 Ensembl:ENSG00000010017 euGenes: HUgn10048
    ECgene: RANBP9 H-InvDB: RANBP9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RANBP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RANBP9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RANBP9 gene:
    Search GeneIP for patents involving RANBP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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