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RANBP9 Gene

protein-coding   GIFtS: 59
GCID: GC06M013621

RAN Binding Protein 9

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAN Binding Protein 91 2     RanBP72 3
RANBPM2 3 5     Novel Centrosomal Protein RanBPM2
Ran Binding Protein In The Microtubule Organizing Center1 2     Ran Binding Protein, Centrosomal2
Ran-Binding Protein M2 3     Ran-Binding Protein 92
BPM-L2 3     RanBP93
BPM902 3     RanBPM3

External Ids:    HGNC: 137271   Entrez Gene: 100482   Ensembl: ENSG000000100177   OMIM: 6038545   UniProtKB: Q96S593   

Export aliases for RANBP9 gene to outside databases

Previous GC identifers: GC06M013679 GC06M013730 GC06M013729 GC06M013566


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RANBP9 Gene:
This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is
essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this
gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain
interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11. (provided by RefSeq, Jul 2008)

GeneCards Summary for RANBP9 Gene:
RANBP9 (RAN binding protein 9) is a protein-coding gene. GO annotations related to this gene include enzyme binding and Ran GTPase binding. An important paralog of this gene is SPRYD3.

UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
Function: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be
involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and
activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as
dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation.
Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic
activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity)

Gene Wiki entry for RANBP9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RANBP9 gene promoter:
         HFH-3   TBP   FosB   CUTL1   E4BP4   Evi-1   FOXI1   TFIID   Chx10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP9 promoter sequence
   Search Chromatin IP Primers for RANBP9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANBP9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p23   Ensembl cytogenetic band:  6p23   HGNC cytogenetic band: 6p23

RANBP9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP9 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M013621:  view genomic region     (about GC identifiers)

Start:
13,621,730 bp from pter      End:
13,711,796 bp from pter
Size:
90,067 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59 (See protein sequence)
Recommended Name: Ran-binding protein 9  
Size: 729 amino acids; 77847 Da
Subunit: Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1,
S100A7, USP11, MKLN1, SOS1 or SOS2, GID8, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B.
Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1
and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and GID8. Part of a complex
consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10
Caution: According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in
microtubule assembly, but other authors infirmed these results in (PubMed:11470507)
Sequence caution: Sequence=AAH19886.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH52781.1; Type=Frameshift; Positions=13, 30, 34; Sequence=AAK15469.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAA23216.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: A0PJA2 O94764 Q6P3T7 Q7LBR2 Q7Z7F9
Alternative splicing: 2 isoforms:  Q96S59-1   Q96S59-2   

Explore the universe of human proteins at neXtProt for RANBP9: NX_Q96S59

Explore proteomics data for RANBP9 at MOPED

Post-translational modifications: 

  • Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C)1
  • Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be
    deubiquitinated by USP111
  • Ubiquitination2 at Lys174, Lys405, Lys445
  • Modification sites at PhosphoSitePlus

  • See RANBP9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005484.2  
    ENSEMBL proteins: 
     ENSP00000011619   ENSP00000438162  
    Reactome Protein details: Q96S59

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR001870 B30.2/SPRY
     IPR027713 RANBP9/RANBP10/Ssh4
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA

    Graphical View of Domain Structure for InterPro Entry Q96S59

    ProtoNet protein and cluster: Q96S59

    2 Blocks protein domains:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
    Domain: The SPRY domain mediates the interaction with MET, AR, and CDC2L1
    Similarity: Belongs to the RANBP9/10 family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    Find genes that share domains with RANBP9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RANB9_HUMAN, Q96S59
    Function: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be
    involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and
    activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as
    dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation.
    Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic
    activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12220523
    GO:0008536Ran GTPase binding TAS9817760
    GO:0019899enzyme binding IPI17087506
         
    Find genes that share ontologies with RANBP9           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for RANBP9:
     Decreased influenza A/WSN/33 r  Increased cell death in breast  Increased cell number in G1, s  Synthetic lethal with c-Myc af 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ranbp9):
     cellular  endocrine/exocrine gland  growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with RANBP9           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RANBP9

    miRNA
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    miRTarBase miRNAs that target RANBP9:
    hsa-mir-101-3p (MIRT027298), hsa-mir-196a-5p (MIRT048208)

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    Selected qRT-PCR Assays for microRNAs that regulate RANBP9 (see all 79):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidRANBP9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RANBP9

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RANB9_HUMAN, Q96S59: Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is
    associated with the plasma membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    cytoskeleton4
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12220523
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005875microtubule associated complex TAS9817760

    Find genes that share ontologies with RANBP9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RANBP9 About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    2Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
    3BDNF signaling pathway
    BDNF signaling pathway


    Find genes that share SuperPaths with RANBP9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RANBP9
        BDNF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

    1 Reactome Pathway for RANBP9
        L1CAM interactions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RANBP9
    Interactions:

        GeneGlobe Interaction Network for RANBP9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RANBP9 (Q96S591, 2, 3 ENSP000000116194) via UniProtKB, MINT, STRING, and/or I2D (see all 140)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    METP085812, 3, ENSP000003172724MINT-18300 MINT-18299 MINT-18298 I2D: score=3 STRING: ENSP00000317272
    DYRK1BQ9Y4631, 3, ENSP000003127894EBI-636085,EBI-634187 I2D: score=5 STRING: ENSP00000312789
    DISC1Q9NRI51, 3, ENSP000003555964EBI-636085,EBI-529989 I2D: score=4 STRING: ENSP00000355596
    S100A7P311511, 3, ENSP000003577114EBI-636085,EBI-357520 I2D: score=4 STRING: ENSP00000357711
    SMAD2Q157962, 3, ENSP000002621604MINT-61580 I2D: score=3 STRING: ENSP00000262160
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006461protein complex assembly TAS9817760
    GO:0007020microtubule nucleation NAS12220523
    GO:0007411axon guidance TAS--

    Find genes that share ontologies with RANBP9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RANBP9 (RANB9)

    1 HMDB Compound for RANBP9    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 Novoseek inferred chemical compound relationship for RANBP9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 3.55 3 12147692 (2)



    Find genes that share compounds with RANBP9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RANBP9 gene: 
    NM_005493.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000011619(uc003nba.3 uc003nbb.3) ENST00000469916 ENST00000539980

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    hsa-miR-579 hsa-miR-3607-3p hsa-miR-607 hsa-miR-374a hsa-miR-30d hsa-miR-30a hsa-miR-208b hsa-miR-200b
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    Selected AceView cDNA sequences (see all 255):

    AA970380 AA737575 CB306781 AW514636 AI499045 AB008515 BP344704 BC053374 
    BM021493 BC063849 AW139025 BU165665 BC019886 CB243386 NM_005493 AA693668 
    BQ129361 AI076142 BU620094 AW178346 BE019086 AU280717 AA485130 BQ129196 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RANBP9 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17 ^
    SP1:        -     -     -                 -     -     -                 -                 -                                                                     
    SP2:                                                                    -                 -                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                    -                 -     -                                                               

    ExUns: 18a · 18b ^ 19a · 19b · 19c ^ 20 ^ 21
    SP1:                                          
    SP2:                                          
    SP3:                                          
    SP4:              -                           
    SP5:                                          


    ECgene alternative splicing isoforms for RANBP9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RANBP9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACGGTGT
    RANBP9 Expression
    About this image


    RANBP9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    RANBP9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RANBP9 Protein Expression

    UniProtKB/Swiss-Prot: RANB9_HUMAN, Q96S59
    Tissue specificity: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest
    levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular
    layer of cerebellum and the Purkinje cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RANBP9 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp91 , 5 RAN binding protein 91, 5 93.73(n)1
    97.85(a)1
      13 (21.60 cM)5
    567051  NM_019930.21  NP_064314.21 
     434026735 
    chicken
    (Gallus gallus)
    Aves RANBP91 RAN binding protein 9 86.39(n)
    95.67(a)
      420836  XM_418927.4  XP_418927.4 
    lizard
    (Anolis carolinensis)
    Reptilia RANBP96
    RAN binding protein 9
    85(a)
    1 ↔ 1
    4(57091947-57130816)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3986772 hypothetical protein LOC398677 81.01(n)    AB018696.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ranbp92 RAN binding protein 9 80.34(n)   266986  57059650 
    fruit fly
    (Drosophila melanogaster)
    Insecta RanBPM1 Ran-binding protein M 54.51(n)
    54.32(a)
      36102  NM_136741.3  NP_610585.2 
    worm
    (Caenorhabditis elegans)
    Secernentea Y54E5A.73 Domain in SPla and the ryanodine
    Receptor.
    37(a)   I(14719226-14722793)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VID306
    Protein involved in proteasome-dependent catabolit...
    14(a)
    1 → many
    VII(69671-72547) YGL227W


    ENSEMBL Gene Tree for RANBP9 (if available)
    TreeFam Gene Tree for RANBP9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RANBP9 gene
    SPRYD32  RANBP102  
    1 SIMAP similar gene for RANBP9 using alignment to 2 protein entries:     RANB9_HUMAN (see all proteins):
    RANBP10

    Find genes that share paralogs with RANBP9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RANBP9 (see all 1918)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs766455141,2
    F--13621698(+) TGCAAG/ATACCT 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1462783391,2
    C--13621709(+) ATATA-/TTAAAC 1 -- ds50010--------
    rs1904454001,2
    --13621726(+) GACACC/TGTATC 1 -- ds50010--------
    rs1833462451,2
    --13621969(+) TTAAAC/TAGGAA 1 -- ut310--------
    rs1889560011,2
    --13622032(+) GGATTG/TTAAGT 1 -- ut310--------
    rs747801321,2
    C--13622132(+) ACTGTC/-CGGAT 1 -- ut311Minor allele frequency- -:0.00NA 2
    rs1923342181,2
    C--13622553(+) GTTGAC/GTATAT 1 -- ut310--------
    rs1157199681,2
    C,F--13622567(+) ACAATA/GTAAGT 1 -- ut312Minor allele frequency- G:0.03NA EU 1443
    rs2011189741,2
    C--13622591(+) ATGCAC/TAGCTA 1 -- ut310--------
    rs1842856771,2
    C--13622613(+) CTTCCA/TCTGTG 2 E V mis10--------

    HapMap Linkage Disequilibrium report for RANBP9 (13621730 - 13711796 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RANBP9:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2674410CNV Deletion23128226
    esv2299523CNV Deletion18987734
    esv2669023CNV Deletion23128226
    dgv6435n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RANBP9
    DNA2.0 Custom Variant and Variant Library Synthesis for RANBP9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603854    OMIM disorders: --


    Find genes that share disorders with RANBP9           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: RANBP9 (1 document)

    Export disorders for RANBP9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RANBP9 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with RANBP9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. When overexpressed, a novel centrosomal protein, RanBPM, causes ectopic microtubule nucleation similar to gamma-tubulin. (PubMed id 9817760)1, 2, 3, 9 Nakamura M.... Nishimoto T. (J. Cell Biol. 1998)
    2. Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex. (PubMed id 11470507)1, 2, 9 Nishitani H.... Nishimoto T. (Gene 2001)
    3. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. (PubMed id 14722085)1, 2, 9 Denti S.... Bianchi E. (J. Biol. Chem. 2004)
    4. Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM. (PubMed id 12084015)1, 2, 9 Ideguchi H.... Ishigatsubo Y. (Biochem. J. 2002)
    5. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PubMed id 12147692)1, 2, 9 Wang D.... Wu G. (J. Biol. Chem. 2002)
    6. The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM. (PubMed id 14511641)1, 2, 9 Mikolajczyk M.... Nelson M. (Biochem. Biophys. Res. Commun. 2003)
    7. The C-terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. (PubMed id 15381419)1, 2, 9 Menon R.P.... Pastore A. (J. Mol. Biol. 2004)
    8. Protein stability and function of p73 are modulated by a physical interaction with RanBPM in mammalian cultured cells. (PubMed id 15558019)1, 2 Kramer S.... Nakagawara A. (Oncogene 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. (PubMed id 12559565)1, 2 Umeda M.... Nishimoto T. (Gene 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10048 HGNC: 13727 AceView: RANBP9 Ensembl:ENSG00000010017 euGenes: HUgn10048
    ECgene: RANBP9 H-InvDB: RANBP9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RANBP9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RANBP9 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RANBP9 gene:
    Search GeneIP for patents involving RANBP9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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