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Aliases for RANBP6 Gene

Aliases for RANBP6 Gene

  • RAN Binding Protein 6 2 3
  • RanBP6 4

External Ids for RANBP6 Gene

Previous GeneCards Identifiers for RANBP6 Gene

  • GC12M009341
  • GC12M009781
  • GC09M006001

Summaries for RANBP6 Gene

GeneCards Summary for RANBP6 Gene

RANBP6 (RAN Binding Protein 6) is a Protein Coding gene. An important paralog of this gene is IPO5.

UniProtKB/Swiss-Prot for RANBP6 Gene

  • May function in nuclear protein import as nuclear transport receptor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP6 Gene

Genomics for RANBP6 Gene

Regulatory Elements for RANBP6 Gene

Genomic Location for RANBP6 Gene

6,011,019 bp from pter
6,015,640 bp from pter
4,622 bases
Minus strand

Genomic View for RANBP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP6 Gene

Proteins for RANBP6 Gene

  • Protein details for RANBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-binding protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5T7X4
    • Q7Z3V2
    • Q96E78

    Protein attributes for RANBP6 Gene

    1105 amino acids
    Molecular mass:
    124714 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RANBP6 Gene

Proteomics data for RANBP6 Gene at MOPED

Post-translational modifications for RANBP6 Gene

  • Ubiquitination at Lys16
  • Modification sites at PhosphoSitePlus

Other Protein References for RANBP6 Gene

Antibody Products

No data available for DME Specific Peptides for RANBP6 Gene

Domains for RANBP6 Gene

Protein Domains for RANBP6 Gene


Suggested Antigen Peptide Sequences for RANBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O60518
  • Belongs to the importin beta family.
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with RANBP6: view

No data available for Gene Families for RANBP6 Gene

Function for RANBP6 Gene

Molecular function for RANBP6 Gene

UniProtKB/Swiss-Prot Function:
May function in nuclear protein import as nuclear transport receptor

Gene Ontology (GO) - Molecular Function for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with RANBP6: view

Phenotypes for RANBP6 Gene

GenomeRNAi human phenotypes for RANBP6:
genes like me logo Genes that share phenotypes with RANBP6: view

Animal Model Products

miRNA for RANBP6 Gene

miRTarBase miRNAs that target RANBP6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RANBP6 Gene

Localization for RANBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for RANBP6 Gene COMPARTMENTS Subcellular localization image for RANBP6 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RANBP6: view

Pathways for RANBP6 Gene

SuperPathways for RANBP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANBP6: view

No data available for Pathways by source for RANBP6 Gene

Compounds for RANBP6 Gene

(1) Novoseek inferred chemical compound relationships for RANBP6 Gene

Compound -log(P) Hits PubMed IDs
gtp 46.4 2
genes like me logo Genes that share compounds with RANBP6: view

Transcripts for RANBP6 Gene

Unigene Clusters for RANBP6 Gene

RAN binding protein 6:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RANBP6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP6 Gene

No ASD Table

Relevant External Links for RANBP6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP6 Gene

mRNA expression in normal human tissues for RANBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RANBP6 Gene

This gene is overexpressed in Bone (47.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP6 Gene

SOURCE GeneReport for Unigene cluster for RANBP6 Gene Hs.167496

genes like me logo Genes that share expressions with RANBP6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for RANBP6 Gene

Orthologs for RANBP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP6 35
  • 95.02 (n)
  • 97.56 (a)
  • 98 (a)
(Canis familiaris)
Mammalia RANBP6 35
  • 95.29 (n)
  • 97.47 (a)
(Mus musculus)
Mammalia Ranbp6 35
  • 91.19 (n)
  • 96.2 (a)
Ranbp6 16
Ranbp6 36
  • 96 (a)
(Pan troglodytes)
Mammalia RANBP6 35
  • 99.79 (n)
  • 99.82 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Ranbp6 35
  • 91.07 (n)
  • 95.38 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
(Gallus gallus)
Aves -- 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 77 (a)
-- 36
  • 71 (a)
(Danio rerio)
Actinopterygii kpnb3 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Karybeta3 36
  • 48 (a)
(Caenorhabditis elegans)
Secernentea imb-3 36
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 36
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10777 36
  • 48 (a)
Species with no ortholog for RANBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP6 Gene

Gene Tree for RANBP6 (if available)
Gene Tree for RANBP6 (if available)

Paralogs for RANBP6 Gene

Paralogs for RANBP6 Gene

Selected SIMAP similar genes for RANBP6 Gene using alignment to 1 proteins: Pseudogenes for RANBP6 Gene

genes like me logo Genes that share paralogs with RANBP6: view

Variants for RANBP6 Gene

Sequence variations from dbSNP and Humsavar for RANBP6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1130 -- 6,012,344(-) GTATC(A/T)CAACT reference, synonymous-codon, utr-variant-3-prime
rs1131 -- 6,012,226(-) TGAAT(A/G)GATTT utr-variant-3-prime
rs7425 -- 6,011,335(-) ATGTA(A/G)TTTTC utr-variant-3-prime
rs106033 -- 6,012,734(+) ACCAG(A/C)AGTGG synonymous-codon, reference, utr-variant-3-prime
rs343500 -- 6,015,011(+) GATAA(C/T)GTCCT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RANBP6 Gene

Variant ID Type Subtype PubMed ID
nsv892155 CNV Gain 21882294
nsv892156 CNV Gain 21882294
dgv1209n67 CNV Gain 20364138
esv27855 CNV Gain 19812545

Relevant External Links for RANBP6 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP6 Gene

Disorders for RANBP6 Gene

Relevant External Links for RANBP6

Genetic Association Database (GAD)

No disorders were found for RANBP6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RANBP6 Gene

Publications for RANBP6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  4. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. (PMID: 8413630) Moore M.S. … Blobel G. (Nature 1993) 23
  5. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. (PMID: 10066803) Lam M.H. … Jans D.A. (J. Biol. Chem. 1999) 23

Products for RANBP6 Gene

Sources for RANBP6 Gene

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