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Aliases for RANBP6 Gene

Aliases for RANBP6 Gene

  • RAN Binding Protein 6 2 3
  • RanBP6 4

External Ids for RANBP6 Gene

Summaries for RANBP6 Gene

GeneCards Summary for RANBP6 Gene

RANBP6 (RAN Binding Protein 6) is a Protein Coding gene. An important paralog of this gene is IPO5.

UniProtKB/Swiss-Prot for RANBP6 Gene

  • May function in nuclear protein import as nuclear transport receptor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP6 Gene

Genomics for RANBP6 Gene

Genomic Location for RANBP6 Gene

Start:
6,011,019 bp from pter
End:
6,015,640 bp from pter
Size:
4,622 bases
Orientation:
Minus strand

Genomic View for RANBP6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP6 Gene

Regulatory Elements for RANBP6 Gene

Proteins for RANBP6 Gene

  • Protein details for RANBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60518-RNBP6_HUMAN
    Recommended name:
    Ran-binding protein 6
    Protein Accession:
    O60518
    Secondary Accessions:
    • Q5T7X4
    • Q7Z3V2
    • Q96E78

    Protein attributes for RANBP6 Gene

    Size:
    1105 amino acids
    Molecular mass:
    124714 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RANBP6 Gene

Proteomics data for RANBP6 Gene at MOPED

Post-translational modifications for RANBP6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys16

Other Protein References for RANBP6 Gene

No data available for DME Specific Peptides for RANBP6 Gene

Domains for RANBP6 Gene

Protein Domains for RANBP6 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RNBP6_HUMAN
Family:
  • Belongs to the importin beta family.:
    • O60518
Similarity:
  • Contains 7 HEAT repeats.:
    • O60518
genes like me logo Genes that share domains with RANBP6: view

No data available for Gene Families for RANBP6 Gene

Function for RANBP6 Gene

Molecular function for RANBP6 Gene

UniProtKB/Swiss-Prot Function: May function in nuclear protein import as nuclear transport receptor

Gene Ontology (GO) - Molecular Function for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with RANBP6: view

Phenotypes for RANBP6 Gene

GenomeRNAi human phenotypes for RANBP6:
genes like me logo Genes that share phenotypes with RANBP6: view

miRNA for RANBP6 Gene

miRTarBase miRNAs that target RANBP6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RANBP6 Gene

Localization for RANBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP6 Gene COMPARTMENTS Subcellular localization image for RANBP6 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RANBP6: view

Pathways for RANBP6 Gene

SuperPathways for RANBP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANBP6: view

No data available for Pathways by source for RANBP6 Gene

Compounds for RANBP6 Gene

(1) Novoseek inferred chemical compound relationships for RANBP6 Gene

Compound -log(P) Hits PubMed IDs
gtp 46.4 2
genes like me logo Genes that share compounds with RANBP6: view

Transcripts for RANBP6 Gene

Unigene Clusters for RANBP6 Gene

RAN binding protein 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP6 Gene

No ASD Table

Relevant External Links for RANBP6 Gene

GeneLoc Exon Structure for
RANBP6
ECgene alternative splicing isoforms for
RANBP6

Expression for RANBP6 Gene

mRNA expression in normal human tissues for RANBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP6 Gene

SOURCE GeneReport for Unigene cluster for RANBP6 Gene Hs.167496

genes like me logo Genes that share expressions with RANBP6: view

Orthologs for RANBP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP6 36
  • 99.79 (n)
  • 99.82 (a)
RANBP6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP6 36
  • 95.02 (n)
  • 97.56 (a)
RANBP6 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP6 36
  • 95.29 (n)
  • 97.47 (a)
mouse
(Mus musculus)
Mammalia Ranbp6 36
  • 91.19 (n)
  • 96.2 (a)
Ranbp6 16
Ranbp6 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ranbp6 36
  • 91.07 (n)
  • 95.38 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 77 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii kpnb3 37
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Karybeta3 37
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea imb-3 37
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 37
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10777 37
  • 48 (a)
OneToMany
Species with no ortholog for RANBP6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP6 Gene

ENSEMBL:
Gene Tree for RANBP6 (if available)
TreeFam:
Gene Tree for RANBP6 (if available)

Paralogs for RANBP6 Gene

Paralogs for RANBP6 Gene

Selected SIMAP similar genes for RANBP6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RANBP6 Gene

genes like me logo Genes that share paralogs with RANBP6: view

Variants for RANBP6 Gene

Sequence variations from dbSNP and Humsavar for RANBP6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1130 -- 6,012,344(-) GTATC(A/T)CAACT reference, synonymous-codon, utr-variant-3-prime
rs1131 -- 6,012,226(-) TGAAT(A/G)GATTT utr-variant-3-prime
rs7425 -- 6,011,335(-) ATGTA(A/G)TTTTC utr-variant-3-prime
rs106033 -- 6,012,734(+) ACCAG(A/C)AGTGG synonymous-codon, reference, utr-variant-3-prime
rs343500 -- 6,015,011(+) GATAA(C/T)GTCCT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for RANBP6 Gene

Variant ID Type Subtype PubMed ID
nsv892155 CNV Gain 21882294
nsv892156 CNV Gain 21882294
dgv1209n67 CNV Gain 20364138
esv27855 CNV Gain 19812545

Relevant External Links for RANBP6 Gene

HapMap Linkage Disequilibrium report
RANBP6
Human Gene Mutation Database (HGMD)
RANBP6

Disorders for RANBP6 Gene

Relevant External Links for RANBP6

Genetic Association Database (GAD)
RANBP6
genes like me logo Genes that share disorders with RANBP6: view

No data available for UniProtKB/Swiss-Prot for RANBP6 Gene

Publications for RANBP6 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. Functional proteomics mapping of a human signaling pathway. (PMID: 15231748) Colland F. … Gauthier J.M. (Genome Res. 2004) 3
  4. The GTP-binding protein Ran/TC4 is required for protein import into the nucleus. (PMID: 8413630) Moore M.S. … Blobel G. (Nature 1993) 23
  5. Importin beta recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin alpha. (PMID: 10066803) Lam M.H. … Jans D.A. (J. Biol. Chem. 1999) 23

Products for RANBP6 Gene

Sources for RANBP6 Gene

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