Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RANBP6 Gene

Aliases for RANBP6 Gene

  • RAN Binding Protein 6 2 3 5
  • RanBP6 4

External Ids for RANBP6 Gene

Previous GeneCards Identifiers for RANBP6 Gene

  • GC12M009341
  • GC12M009781
  • GC09M006001

Summaries for RANBP6 Gene

GeneCards Summary for RANBP6 Gene

RANBP6 (RAN Binding Protein 6) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is IPO5.

UniProtKB/Swiss-Prot for RANBP6 Gene

  • May function in nuclear protein import as nuclear transport receptor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP6 Gene

Genomics for RANBP6 Gene

Regulatory Elements for RANBP6 Gene

Enhancers for RANBP6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F005841 1.4 FANTOM5 Ensembl ENCODE 1.7 +171.6 171582 5.5 HDGF PKNOX1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF121 ZNF143 ZNF263 ERMP1 RANBP6 GC09M005843 AK4P4
GH09F005623 1.2 FANTOM5 ENCODE 1.1 +388.4 388401 7.1 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 RIC1 PLGRKT KIAA2026 CD274 RANBP6 GC09P005625 LOC105375967
GH09F006014 0.5 ENCODE 0.8 +0.3 307 2.0 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS CEBPZ RIC1 ERMP1 RANBP6 KIAA2026
GH09F006024 0.7 Ensembl ENCODE 0.4 -8.6 -8561 0.4 CTCF ZBTB11 DPF2 RAD21 ZNF644 CTBP1 GATA3 SCRT2 IKZF1 CUX1 KIAA2026 RANBP6 ENSG00000228739
GH09F006037 0.5 Ensembl 0.3 -22.4 -22361 0.8 ENSG00000228739 RANBP6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RANBP6 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001907234 140 1800 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS CEBPZ

Genomic Location for RANBP6 Gene

Chromosome:
9
Start:
6,011,019 bp from pter
End:
6,015,640 bp from pter
Size:
4,622 bases
Orientation:
Minus strand

Genomic View for RANBP6 Gene

Genes around RANBP6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP6 Gene

Proteins for RANBP6 Gene

  • Protein details for RANBP6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60518-RNBP6_HUMAN
    Recommended name:
    Ran-binding protein 6
    Protein Accession:
    O60518
    Secondary Accessions:
    • Q5T7X4
    • Q7Z3V2
    • Q96E78

    Protein attributes for RANBP6 Gene

    Size:
    1105 amino acids
    Molecular mass:
    124714 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD97647.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RANBP6 Gene

Post-translational modifications for RANBP6 Gene

  • Ubiquitination at Lys 16
  • Modification sites at PhosphoSitePlus

Other Protein References for RANBP6 Gene

No data available for DME Specific Peptides for RANBP6 Gene

Domains & Families for RANBP6 Gene

Protein Domains for RANBP6 Gene

Suggested Antigen Peptide Sequences for RANBP6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60518

UniProtKB/Swiss-Prot:

RNBP6_HUMAN :
  • Belongs to the importin beta family.
  • Contains 7 HEAT repeats.
Family:
  • Belongs to the importin beta family.
Similarity:
  • Contains 7 HEAT repeats.
genes like me logo Genes that share domains with RANBP6: view

No data available for Gene Families for RANBP6 Gene

Function for RANBP6 Gene

Molecular function for RANBP6 Gene

UniProtKB/Swiss-Prot Function:
May function in nuclear protein import as nuclear transport receptor.

Gene Ontology (GO) - Molecular Function for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
GO:0008139 nuclear localization sequence binding IBA --
GO:0008565 protein transporter activity IBA --
genes like me logo Genes that share ontologies with RANBP6: view
genes like me logo Genes that share phenotypes with RANBP6: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP6 Gene

Localization for RANBP6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP6 Gene COMPARTMENTS Subcellular localization image for RANBP6 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA --
GO:0031965 nuclear membrane IBA --
GO:0034399 nuclear periphery IBA --
genes like me logo Genes that share ontologies with RANBP6: view

Pathways & Interactions for RANBP6 Gene

SuperPathways for RANBP6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000059 protein import into nucleus, docking IBA --
GO:0000060 protein import into nucleus, translocation IBA --
GO:0006607 NLS-bearing protein import into nucleus IBA --
GO:0006610 ribosomal protein import into nucleus IBA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RANBP6: view

No data available for Pathways by source and SIGNOR curated interactions for RANBP6 Gene

Drugs & Compounds for RANBP6 Gene

(1) Additional Compounds for RANBP6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP6: view

Transcripts for RANBP6 Gene

Unigene Clusters for RANBP6 Gene

RAN binding protein 6:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP6 Gene

No ASD Table

Relevant External Links for RANBP6 Gene

GeneLoc Exon Structure for
RANBP6
ECgene alternative splicing isoforms for
RANBP6

Expression for RANBP6 Gene

mRNA expression in normal human tissues for RANBP6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP6 Gene

This gene is overexpressed in Bone (47.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP6 Gene



NURSA nuclear receptor signaling pathways regulating expression of RANBP6 Gene:

RANBP6

SOURCE GeneReport for Unigene cluster for RANBP6 Gene:

Hs.167496
genes like me logo Genes that share expression patterns with RANBP6: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for RANBP6 Gene

Orthologs for RANBP6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP6 34 35
  • 99.79 (n)
dog
(Canis familiaris)
Mammalia RANBP6 34
  • 95.29 (n)
cow
(Bos Taurus)
Mammalia RANBP6 34 35
  • 95.02 (n)
mouse
(Mus musculus)
Mammalia Ranbp6 34 16 35
  • 91.19 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp6 34
  • 91.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 76 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 77 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 77 (a)
ManyToMany
-- 35
  • 71 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii kpnb3 35
  • 74 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Karybeta3 35
  • 48 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea imb-3 35
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSE1 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10777 35
  • 48 (a)
OneToMany
Species where no ortholog for RANBP6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP6 Gene

ENSEMBL:
Gene Tree for RANBP6 (if available)
TreeFam:
Gene Tree for RANBP6 (if available)

Paralogs for RANBP6 Gene

Paralogs for RANBP6 Gene

(1) SIMAP similar genes for RANBP6 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RANBP6 Gene

genes like me logo Genes that share paralogs with RANBP6: view

Variants for RANBP6 Gene

Sequence variations from dbSNP and Humsavar for RANBP6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10118943 -- 6,014,332(+) GGCTG(C/T)AGCCC reference, missense
rs106033 -- 6,012,734(+) ACCAG(A/C)AGTGG reference, synonymous-codon, utr-variant-3-prime
rs10758736 -- 6,011,757(+) ATGAA(A/G)AAGTT utr-variant-3-prime
rs111505202 -- 6,015,327(+) CTCTC(C/T)GAACA intron-variant, reference, missense
rs111770570 -- 6,011,028(+) GGTAC(A/G)AACAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RANBP6 Gene

Variant ID Type Subtype PubMed ID
dgv1209n67 CNV gain 20364138
esv27855 CNV gain 19812545
nsv1015450 CNV loss 25217958
nsv1029665 CNV gain 25217958
nsv972646 CNV duplication 23825009

Variation tolerance for RANBP6 Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.13; 38.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP6 Gene

Human Gene Mutation Database (HGMD)
RANBP6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP6 Gene

Disorders for RANBP6 Gene

Relevant External Links for RANBP6

Genetic Association Database (GAD)
RANBP6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP6

No disorders were found for RANBP6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP6 Gene

Publications for RANBP6 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for RANBP6 Gene

Sources for RANBP6 Gene

Content
Loading form....