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Aliases for RANBP3L Gene

Aliases for RANBP3L Gene

  • RAN Binding Protein 3 Like 2 3 5
  • RAN Binding Protein 3-Like 2

External Ids for RANBP3L Gene

Summaries for RANBP3L Gene

GeneCards Summary for RANBP3L Gene

RANBP3L (RAN Binding Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is RANBP3.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP3L Gene

Genomics for RANBP3L Gene

Regulatory Elements for RANBP3L Gene

Enhancers for RANBP3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G036238 1.5 FANTOM5 ENCODE 19.5 +60.9 60872 4.7 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 SP3 RANBP3L NADK2 SLC1A3 NADK2-AS1
GH05G036688 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -387.9 -387888 2.4 PKNOX1 WRNIP1 SIN3A ZNF2 ZNF143 ZNF416 ZNF207 ZNF263 SP3 ZHX2 ENSG00000250155 WDR70 SLC1A3 RANBP3L NIPBL GC05P036714 ENSG00000279400
GH05G036691 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -390.3 -390300 2.3 RB1 WRNIP1 ZNF48 ZNF2 RAD21 RFX5 ZNF121 ZNF366 ZNF143 RCOR1 ENSG00000250155 SLC1A3 NADK2 RANBP3L NIPBL GC05P036714 ENSG00000279400
GH05G036402 1.2 Ensembl ENCODE 11.2 -101.7 -101658 2.5 FOXA2 ATF1 MLX YY1 MIER2 PPARG KAT8 NFIL3 MIER3 RFX3 RANBP3L SLC1A3 LOC105374725 RNA5SP181
GH05G036682 1.2 Ensembl ENCODE dbSUPER 10.9 -382.4 -382419 3.7 ZBED1 NR2F1 MAX JUNB CEBPB DPF2 CEBPG REST EED TCF7 ENSG00000250155 C5orf42 SLC1A3 NADK2 RANBP3L ENSG00000279400 GC05P036714
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RANBP3L on UCSC Golden Path with GeneCards custom track

Promoters for RANBP3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179517 14 201 INSM2 FEZF1 ZNF2 RAD21 YY1 ZSCAN5C ZNF350 KLF7 ZNF391 ZBTB11

Genomic Location for RANBP3L Gene

36,247,874 bp from pter
36,302,114 bp from pter
54,241 bases
Minus strand

Genomic View for RANBP3L Gene

Genes around RANBP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP3L Gene

Proteins for RANBP3L Gene

  • Protein details for RANBP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-binding protein 3-like
    Protein Accession:
    Secondary Accessions:
    • B7Z866
    • E9PGP9
    • Q96LK2

    Protein attributes for RANBP3L Gene

    465 amino acids
    Molecular mass:
    52211 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RANBP3L Gene


neXtProt entry for RANBP3L Gene

Post-translational modifications for RANBP3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP3L Gene

Domains & Families for RANBP3L Gene

Protein Domains for RANBP3L Gene


Suggested Antigen Peptide Sequences for RANBP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RANBP3L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RANBP3L Gene

Function for RANBP3L Gene

Gene Ontology (GO) - Molecular Function for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 contributes_to GTPase activator activity IBA --
GO:0008536 Ran GTPase binding IBA --
GO:0046332 SMAD binding IPI 25755279
genes like me logo Genes that share ontologies with RANBP3L: view
genes like me logo Genes that share phenotypes with RANBP3L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP3L Gene

Localization for RANBP3L Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP3L gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0005813 centrosome IBA --
genes like me logo Genes that share ontologies with RANBP3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP3L Gene

Pathways & Interactions for RANBP3L Gene

SuperPathways for RANBP3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA --
GO:0006405 RNA export from nucleus IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0006606 protein import into nucleus IBA --
GO:0007051 spindle organization IBA --
genes like me logo Genes that share ontologies with RANBP3L: view

No data available for Pathways by source and SIGNOR curated interactions for RANBP3L Gene

Drugs & Compounds for RANBP3L Gene

No Compound Related Data Available

Transcripts for RANBP3L Gene

Unigene Clusters for RANBP3L Gene

RAN binding protein 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP3L Gene

No ASD Table

Relevant External Links for RANBP3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RANBP3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.9), Brain - Amygdala (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RANBP3L Gene

This gene is overexpressed in Bone (58.2) and Stomach (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RANBP3L Gene

Protein tissue co-expression partners for RANBP3L Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP3L Gene:


SOURCE GeneReport for Unigene cluster for RANBP3L Gene:


Evidence on tissue expression from TISSUES for RANBP3L Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RANBP3L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP3L Gene

Orthologs for RANBP3L Gene

This gene was present in the common ancestor of animals.

Orthologs for RANBP3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RANBP3L 34 35
  • 99.52 (n)
(Canis familiaris)
Mammalia RANBP3L 34 35
  • 87.62 (n)
(Bos Taurus)
Mammalia RANBP3L 34 35
  • 85.02 (n)
(Mus musculus)
Mammalia Ranbp3l 34 16 35
  • 78.85 (n)
(Rattus norvegicus)
Mammalia Ranbp3l 34
  • 76.8 (n)
(Monodelphis domestica)
Mammalia RANBP3L 35
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia RANBP3L 35
  • 50 (a)
(Gallus gallus)
Aves RANBP3L 34 35
  • 66.26 (n)
(Anolis carolinensis)
Reptilia RANBP3L 35
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp3l 34
  • 50.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta RanBP3 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea ran-5 35
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2235 35
  • 21 (a)
-- 35
  • 15 (a)
Species where no ortholog for RANBP3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RANBP3L Gene

Gene Tree for RANBP3L (if available)
Gene Tree for RANBP3L (if available)

Paralogs for RANBP3L Gene

Paralogs for RANBP3L Gene

(1) SIMAP similar genes for RANBP3L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RANBP3L: view

Variants for RANBP3L Gene

Sequence variations from dbSNP and Humsavar for RANBP3L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000094941 -- 36,285,155(+) AATGT(C/G)ATTTG intron-variant
rs1000130597 -- 36,278,903(+) GAAAA(A/G)GTCAC intron-variant
rs1000141371 -- 36,260,078(+) TAAGA(A/G)CAAAT intron-variant
rs1000172021 -- 36,260,428(+) ATGAC(A/G)TCGAC intron-variant
rs1000275344 -- 36,299,304(+) ACATA(C/T)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP3L Gene

Variant ID Type Subtype PubMed ID
esv2730076 CNV deletion 23290073
esv2730077 CNV deletion 23290073
esv2762515 CNV loss 21179565
esv3575836 CNV gain 25503493
esv3604707 CNV gain 21293372
esv3604714 CNV gain 21293372
esv3604715 CNV loss 21293372
nsv1015638 CNV gain 25217958
nsv830262 CNV gain 17160897

Variation tolerance for RANBP3L Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP3L Gene

Disorders for RANBP3L Gene

Relevant External Links for RANBP3L

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RANBP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP3L Gene

Publications for RANBP3L Gene

  1. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. (PMID: 25755279) Chen F. … Feng X.H. (Mol. Cell. Biol. 2015) 2 3 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. Impact of four loci on serum tamsulosin hydrochloride concentration. (PMID: 23151678) Takata R. … Nakamura Y. (J. Hum. Genet. 2013) 3 64
  4. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 46 64
  5. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. (PMID: 21626137) Slavin T.P. … Elston R.C. (Hum. Genet. 2011) 3 64

Products for RANBP3L Gene

Sources for RANBP3L Gene

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