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Aliases for RANBP3L Gene

Aliases for RANBP3L Gene

  • RAN Binding Protein 3 Like 2 3 5
  • RAN Binding Protein 3-Like 2

External Ids for RANBP3L Gene

Summaries for RANBP3L Gene

GeneCards Summary for RANBP3L Gene

RANBP3L (RAN Binding Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is RANBP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP3L Gene

Genomics for RANBP3L Gene

Regulatory Elements for RANBP3L Gene

Enhancers for RANBP3L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F036238 1.5 FANTOM5 ENCODE 19.4 +60.9 60872 4.7 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC RANBP3L OFD1P17 ENSG00000272103 SPEF2 NADK2 SLC1A3 NADK2-AS1
GH05F036688 1.7 FANTOM5 Ensembl ENCODE 10.9 -389.1 -389087 4.8 PKNOX1 WRNIP1 SIN3A ZNF2 ZNF416 ZNF207 ZNF143 DEK ZNF263 SP3 WDR70 ENSG00000250155 ENSG00000250455 LOC105374724 LOC100506406 SLC1A3 C5orf42 NADK2 RANBP3L NIPBL
GH05F036402 1.2 Ensembl ENCODE 11.2 -101.7 -101658 2.5 ELF3 ATF1 MLX THRB ZSCAN9 RAD21 RARA YY1 KAT2B GATA4 RANBP3L SLC1A3 LOC105374725 RNA5SP181
GH05F036174 0.6 FANTOM5 17 +127.7 127730 0.3 RAD21 PRDM1 RANBP3L SLC1A3 LMBRD2 NADK2 PIR31598 NADK2-AS1
GH05F036230 0.6 Ensembl 16.9 +71.8 71814 0.2 ARID1B RNF2 IKZF1 HMBOX1 PRDM1 RANBP3L NADK2-AS1 NADK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RANBP3L on UCSC Golden Path with GeneCards custom track

Promoters for RANBP3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001868185 14 1000 INSM2 FEZF1 RAD21 ZNF2 YY1 KLF7 ZNF391 ZBTB11 OVOL3 TSHZ1

Genomic Location for RANBP3L Gene

Chromosome:
5
Start:
36,247,874 bp from pter
End:
36,302,114 bp from pter
Size:
54,241 bases
Orientation:
Minus strand

Genomic View for RANBP3L Gene

Genes around RANBP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP3L Gene

Proteins for RANBP3L Gene

  • Protein details for RANBP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VV4-RNB3L_HUMAN
    Recommended name:
    Ran-binding protein 3-like
    Protein Accession:
    Q86VV4
    Secondary Accessions:
    • B7Z866
    • E9PGP9
    • Q96LK2

    Protein attributes for RANBP3L Gene

    Size:
    465 amino acids
    Molecular mass:
    52211 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RANBP3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP3L Gene

Post-translational modifications for RANBP3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP3L Gene

Domains & Families for RANBP3L Gene

Protein Domains for RANBP3L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RANBP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VV4

UniProtKB/Swiss-Prot:

RNB3L_HUMAN :
  • Contains 1 RanBD1 domain.
Domain:
  • Contains 1 RanBD1 domain.
genes like me logo Genes that share domains with RANBP3L: view

No data available for Gene Families for RANBP3L Gene

Function for RANBP3L Gene

Gene Ontology (GO) - Molecular Function for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding IBA --
GO:0070412 R-SMAD binding IBA --
genes like me logo Genes that share ontologies with RANBP3L: view
genes like me logo Genes that share phenotypes with RANBP3L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP3L Gene

Localization for RANBP3L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP3L gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with RANBP3L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP3L Gene

Pathways & Interactions for RANBP3L Gene

SuperPathways for RANBP3L Gene

No Data Available

Gene Ontology (GO) - Biological Process for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046827 positive regulation of protein export from nucleus IBA --
GO:0046907 intracellular transport IEA --
genes like me logo Genes that share ontologies with RANBP3L: view

No data available for Pathways by source and SIGNOR curated interactions for RANBP3L Gene

Transcripts for RANBP3L Gene

Unigene Clusters for RANBP3L Gene

RAN binding protein 3-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP3L Gene

No ASD Table

Relevant External Links for RANBP3L Gene

GeneLoc Exon Structure for
RANBP3L
ECgene alternative splicing isoforms for
RANBP3L

Expression for RANBP3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RANBP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RANBP3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.9), Brain - Amygdala (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RANBP3L Gene

This gene is overexpressed in Bone (58.2) and Stomach (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RANBP3L Gene



Protein tissue co-expression partners for RANBP3L Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP3L Gene:

RANBP3L

SOURCE GeneReport for Unigene cluster for RANBP3L Gene:

Hs.729817
genes like me logo Genes that share expression patterns with RANBP3L: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RANBP3L Gene

Orthologs for RANBP3L Gene

This gene was present in the common ancestor of animals.

Orthologs for RANBP3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP3L 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia RANBP3L 34 35
  • 87.62 (n)
cow
(Bos Taurus)
Mammalia RANBP3L 34 35
  • 85.02 (n)
mouse
(Mus musculus)
Mammalia Ranbp3l 34 16 35
  • 78.85 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp3l 34
  • 76.8 (n)
oppossum
(Monodelphis domestica)
Mammalia RANBP3L 35
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP3L 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP3L 34 35
  • 66.26 (n)
lizard
(Anolis carolinensis)
Reptilia RANBP3L 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp3l 34
  • 50.07 (n)
fruit fly
(Drosophila melanogaster)
Insecta RanBP3 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-5 35
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2235 35
  • 21 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
Species where no ortholog for RANBP3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RANBP3L Gene

ENSEMBL:
Gene Tree for RANBP3L (if available)
TreeFam:
Gene Tree for RANBP3L (if available)

Paralogs for RANBP3L Gene

Paralogs for RANBP3L Gene

(1) SIMAP similar genes for RANBP3L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RANBP3L: view

Variants for RANBP3L Gene

Sequence variations from dbSNP and Humsavar for RANBP3L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10035473 -- 36,255,721(+) AAACC(A/G)GCTTT intron-variant
rs10039862 -- 36,289,047(+) gcttt(A/G)tatat intron-variant
rs10041655 -- 36,256,112(+) GATAA(C/G)GTGGA intron-variant
rs10041692 -- 36,256,113(+) ATAAC(A/G)TGGAG intron-variant
rs10042405 -- 36,287,089(+) cgcct(C/T)agatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP3L Gene

Variant ID Type Subtype PubMed ID
nsv830262 CNV gain 17160897
nsv1015638 CNV gain 25217958
esv3604715 CNV loss 21293372
esv3604714 CNV gain 21293372
esv3604707 CNV gain 21293372
esv3575836 CNV gain 25503493
esv2762515 CNV loss 21179565
esv2730077 CNV deletion 23290073
esv2730076 CNV deletion 23290073

Variation tolerance for RANBP3L Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP3L Gene

Disorders for RANBP3L Gene

Relevant External Links for RANBP3L

Genetic Association Database (GAD)
RANBP3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP3L

No disorders were found for RANBP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP3L Gene

Publications for RANBP3L Gene

  1. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. (PMID: 25755279) Chen F. … Feng X.H. (Mol. Cell. Biol. 2015) 2 3 64
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  3. Impact of four loci on serum tamsulosin hydrochloride concentration. (PMID: 23151678) Takata R. … Nakamura Y. (J. Hum. Genet. 2013) 3 64
  4. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. (PMID: 21626137) Slavin T.P. … Elston R.C. (Hum. Genet. 2011) 3 64
  5. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A. … Haiman C.A. (PLoS Genet. 2011) 46 64

Products for RANBP3L Gene

Sources for RANBP3L Gene

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