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Aliases for RANBP3L Gene

Aliases for RANBP3L Gene

  • RAN Binding Protein 3 Like 2 3
  • RAN Binding Protein 3-Like 2 5

External Ids for RANBP3L Gene

Summaries for RANBP3L Gene

GeneCards Summary for RANBP3L Gene

RANBP3L (RAN Binding Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is RANBP3.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP3L Gene

Genomics for RANBP3L Gene

Regulatory Elements for RANBP3L Gene

Promoters for RANBP3L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANBP3L on UCSC Golden Path with GeneCards custom track

Genomic Location for RANBP3L Gene

Chromosome:
5
Start:
36,247,874 bp from pter
End:
36,302,114 bp from pter
Size:
54,241 bases
Orientation:
Minus strand

Genomic View for RANBP3L Gene

Genes around RANBP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP3L Gene

Proteins for RANBP3L Gene

  • Protein details for RANBP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VV4-RNB3L_HUMAN
    Recommended name:
    Ran-binding protein 3-like
    Protein Accession:
    Q86VV4
    Secondary Accessions:
    • B7Z866
    • E9PGP9
    • Q96LK2

    Protein attributes for RANBP3L Gene

    Size:
    465 amino acids
    Molecular mass:
    52211 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RANBP3L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP3L Gene

Proteomics data for RANBP3L Gene at MOPED

Post-translational modifications for RANBP3L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP3L Gene

Domains & Families for RANBP3L Gene

Protein Domains for RANBP3L Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RANBP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VV4

UniProtKB/Swiss-Prot:

RNB3L_HUMAN :
  • Contains 1 RanBD1 domain.
Domain:
  • Contains 1 RanBD1 domain.
genes like me logo Genes that share domains with RANBP3L: view

No data available for Gene Families for RANBP3L Gene

Function for RANBP3L Gene

Gene Ontology (GO) - Molecular Function for RANBP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding IBA --
genes like me logo Genes that share ontologies with RANBP3L: view
genes like me logo Genes that share phenotypes with RANBP3L: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP3L Gene

Localization for RANBP3L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP3L Gene COMPARTMENTS Subcellular localization image for RANBP3L gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RANBP3L Gene

Pathways & Interactions for RANBP3L Gene

SuperPathways for RANBP3L Gene

No Data Available

Interacting Proteins for RANBP3L Gene

Gene Ontology (GO) - Biological Process for RANBP3L Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RANBP3L Gene

Drugs & Compounds for RANBP3L Gene

No Compound Related Data Available

Transcripts for RANBP3L Gene

Unigene Clusters for RANBP3L Gene

RAN binding protein 3-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP3L Gene

No ASD Table

Relevant External Links for RANBP3L Gene

GeneLoc Exon Structure for
RANBP3L
ECgene alternative splicing isoforms for
RANBP3L

Expression for RANBP3L Gene

mRNA expression in normal human tissues for RANBP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RANBP3L Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Caudate (basal ganglia) (x4.9), Brain - Amygdala (x4.9), and Brain - Putamen (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RANBP3L Gene

This gene is overexpressed in Bone (58.2) and Stomach (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RANBP3L Gene



SOURCE GeneReport for Unigene cluster for RANBP3L Gene Hs.729817

genes like me logo Genes that share expression patterns with RANBP3L: view

Protein tissue co-expression partners for RANBP3L Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RANBP3L Gene

Orthologs for RANBP3L Gene

This gene was present in the common ancestor of animals.

Orthologs for RANBP3L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP3L 35
  • 99.52 (n)
  • 98.78 (a)
RANBP3L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP3L 36
  • 74 (a)
OneToOne
RANBP3L 35
  • 85.02 (n)
  • 74.61 (a)
dog
(Canis familiaris)
Mammalia RANBP3L 35
  • 87.62 (n)
  • 80.61 (a)
RANBP3L 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp3l 16
Ranbp3l 35
  • 78.85 (n)
  • 71.05 (a)
Ranbp3l 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP3L 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP3L 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp3l 35
  • 76.8 (n)
  • 70.4 (a)
chicken
(Gallus gallus)
Aves RANBP3L 35
  • 66.26 (n)
  • 58.85 (a)
RANBP3L 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP3L 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp3l 35
  • 50.07 (n)
  • 40.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta RanBP3 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-5 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
ManyToMany
CSA.2235 36
  • 21 (a)
ManyToMany
Species with no ortholog for RANBP3L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for RANBP3L Gene

ENSEMBL:
Gene Tree for RANBP3L (if available)
TreeFam:
Gene Tree for RANBP3L (if available)

Paralogs for RANBP3L Gene

Paralogs for RANBP3L Gene

(1) SIMAP similar genes for RANBP3L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RANBP3L: view

Variants for RANBP3L Gene

Sequence variations from dbSNP and Humsavar for RANBP3L Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1035480 - 36,269,449(-) TCCAA(C/G)AAAGC intron-variant, reference, missense
rs35433829 - 36,265,457(+) GTTCA(G/T)CACTC reference, missense
rs16902872 - 36,257,032(+) CAGCA(A/G/T)CTGAT reference, missense
rs716636 -- 36,279,707(-) ATAAG(G/T)GTTCC intron-variant
rs716637 -- 36,279,840(-) GTGTT(A/T)GTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP3L Gene

Variant ID Type Subtype PubMed ID
nsv830262 CNV Gain 17160897
nsv881598 CNV Gain 21882294
esv2730076 CNV Deletion 23290073
esv2730077 CNV Deletion 23290073

Variation tolerance for RANBP3L Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.04; 75.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP3L Gene

HapMap Linkage Disequilibrium report
RANBP3L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP3L Gene

Disorders for RANBP3L Gene

Relevant External Links for RANBP3L

Genetic Association Database (GAD)
RANBP3L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP3L

No disorders were found for RANBP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP3L Gene

Publications for RANBP3L Gene

  1. Nuclear Export of Smads by RanBP3L Regulates Bone Morphogenetic Protein Signaling and Mesenchymal Stem Cell Differentiation. (PMID: 25755279) Chen F. … Feng X.H. (Mol. Cell. Biol. 2015) 2 3 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. Impact of four loci on serum tamsulosin hydrochloride concentration. (PMID: 23151678) Takata R. … Nakamura Y. (J. Hum. Genet. 2013) 3
  4. Two-marker association tests yield new disease associations for coronary artery disease and hypertension. (PMID: 21626137) Slavin T.P. … Elston R.C. (Hum. Genet. 2011) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RANBP3L Gene

Sources for RANBP3L Gene

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