External Ids for RANBP3 Gene
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
GeneCards Summary for RANBP3 Gene
RANBP3 (RAN Binding Protein 3) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and MAPK targets/ Nuclear events mediated by MAP kinases. GO annotations related to this gene include Ran GTPase binding and R-SMAD binding. An important paralog of this gene is RANBP3L.
UniProtKB/Swiss-Prot for RANBP3 Gene
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.