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Aliases for RANBP3 Gene

Aliases for RANBP3 Gene

  • RAN Binding Protein 3 2 3 5
  • RanBP3 4

External Ids for RANBP3 Gene

Previous GeneCards Identifiers for RANBP3 Gene

  • GC19M006008
  • GC19M005856
  • GC19M005867
  • GC19M005675

Summaries for RANBP3 Gene

Entrez Gene Summary for RANBP3 Gene

  • This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for RANBP3 Gene

RANBP3 (RAN Binding Protein 3) is a Protein Coding gene. Among its related pathways are HTLV-I infection and PI3K / Akt Signaling. GO annotations related to this gene include Ran GTPase binding and R-SMAD binding. An important paralog of this gene is RANBP3L.

UniProtKB/Swiss-Prot for RANBP3 Gene

  • Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene Wiki entry for RANBP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP3 Gene

Genomics for RANBP3 Gene

Regulatory Elements for RANBP3 Gene

Enhancers for RANBP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RANBP3 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RANBP3 Gene

Chromosome:
19
Start:
5,916,139 bp from pter
End:
5,978,309 bp from pter
Size:
62,171 bases
Orientation:
Minus strand

Genomic View for RANBP3 Gene

Genes around RANBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP3 Gene

Proteins for RANBP3 Gene

  • Protein details for RANBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Z4-RANB3_HUMAN
    Recommended name:
    Ran-binding protein 3
    Protein Accession:
    Q9H6Z4
    Secondary Accessions:
    • B2RAT8
    • O60405
    • O75759
    • O75760
    • Q9BT47
    • Q9UG74

    Protein attributes for RANBP3 Gene

    Size:
    567 amino acids
    Molecular mass:
    60210 Da
    Quaternary structure:
    • Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3 (dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and termination of the TGF-beta signaling.
    SequenceCaution:
    • Sequence=AAH04349.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=CAB43293.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RANBP3 Gene

    Alternative splice isoforms for RANBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP3 Gene

Proteomics data for RANBP3 Gene at MOPED

Post-translational modifications for RANBP3 Gene

  • Ubiquitination at Lys 413
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RANBP3 (RANBP3)

No data available for DME Specific Peptides for RANBP3 Gene

Domains & Families for RANBP3 Gene

Protein Domains for RANBP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RANBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H6Z4

UniProtKB/Swiss-Prot:

RANB3_HUMAN :
  • Contains 1 RanBD1 domain.
Domain:
  • Contains 1 RanBD1 domain.
genes like me logo Genes that share domains with RANBP3: view

No data available for Gene Families for RANBP3 Gene

Function for RANBP3 Gene

Molecular function for RANBP3 Gene

GENATLAS Biochemistry:
RAN binding protein 3,localized in the nucleus,nuclear effector of the RAN pathway,preferentially bound to importin alpha 3
UniProtKB/Swiss-Prot Function:
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.

Gene Ontology (GO) - Molecular Function for RANBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008536 Ran GTPase binding IPI 9637251
genes like me logo Genes that share ontologies with RANBP3: view
genes like me logo Genes that share phenotypes with RANBP3: view

Animal Model Products

miRNA for RANBP3 Gene

miRTarBase miRNAs that target RANBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP3 Gene

Localization for RANBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP3 Gene COMPARTMENTS Subcellular localization image for RANBP3 gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for RANBP3 Gene

Pathways & Interactions for RANBP3 Gene

genes like me logo Genes that share pathways with RANBP3: view

Pathways by source for RANBP3 Gene

3 Cell Signaling Technology pathways for RANBP3 Gene
1 BioSystems pathway for RANBP3 Gene
1 KEGG pathway for RANBP3 Gene

SIGNOR curated interactions for RANBP3 Gene

Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for RANBP3 Gene

None

Drugs & Compounds for RANBP3 Gene

(3) Drugs for RANBP3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANBP3: view

Transcripts for RANBP3 Gene

Unigene Clusters for RANBP3 Gene

RAN binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: - - -
SP7: - - - - - - - - - - - - - - - - - - - - - -
SP8: - -
SP9: - - -
SP10: -
SP11:

ExUns: 17a · 17b ^ 18 ^ 19a · 19b · 19c
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:

Relevant External Links for RANBP3 Gene

GeneLoc Exon Structure for
RANBP3
ECgene alternative splicing isoforms for
RANBP3

Expression for RANBP3 Gene

mRNA expression in normal human tissues for RANBP3 Gene

Protein differential expression in normal tissues from HIPED for RANBP3 Gene

This gene is overexpressed in Nasal epithelium (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP3 Gene



SOURCE GeneReport for Unigene cluster for RANBP3 Gene Hs.531752

mRNA Expression by UniProt/SwissProt for RANBP3 Gene

Q9H6Z4-RANB3_HUMAN
Tissue specificity: Widely expressed with high levels in testis and heart.
genes like me logo Genes that share expression patterns with RANBP3: view

Protein tissue co-expression partners for RANBP3 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RANBP3 Gene

Orthologs for RANBP3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia RANBP3 35
  • 89.45 (n)
  • 91.82 (a)
RANBP3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp3 35
  • 79.15 (n)
  • 80.29 (a)
Ranbp3 16
Ranbp3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RANBP3 35
  • 99.47 (n)
  • 99.64 (a)
RANBP3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp3 35
  • 79.69 (n)
  • 79.75 (a)
cow
(Bos Taurus)
Mammalia RANBP3 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP3 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP3 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.946 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12030 35
zebrafish
(Danio rerio)
Actinopterygii zgc66385 35
ranbp3a 36
  • 52 (a)
OneToMany
ranbp3b 36
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3866 35
fruit fly
(Drosophila melanogaster)
Insecta RanBP3 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ran-5 36
  • 24 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB2 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
ManyToMany
CSA.2235 36
  • 29 (a)
ManyToMany
Species with no ortholog for RANBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP3 Gene

ENSEMBL:
Gene Tree for RANBP3 (if available)
TreeFam:
Gene Tree for RANBP3 (if available)

Paralogs for RANBP3 Gene

Paralogs for RANBP3 Gene

genes like me logo Genes that share paralogs with RANBP3: view

Variants for RANBP3 Gene

Sequence variations from dbSNP and Humsavar for RANBP3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10417885 - 5,924,882(+) CGTCG(A/G)CACTA reference, missense
rs757441 -- 5,933,159(+) AGCCC(A/G)CCCGA intron-variant
rs758511 -- 5,969,118(+) GAGGA(C/G)AACGG intron-variant
rs7258475 -- 5,943,295(+) GCTTT(G/T)CAAAC intron-variant
rs7259761 -- 5,952,702(+) AAGCA(A/G)TGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP3 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910904 CNV Loss 21882294
nsv910905 CNV Loss 21882294
nsv910907 CNV Loss 21882294

Variation tolerance for RANBP3 Gene

Residual Variation Intolerance Score: 6.46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.11; 51.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RANBP3 Gene

Disorders for RANBP3 Gene

Relevant External Links for RANBP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP3

No disorders were found for RANBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP3 Gene

Publications for RANBP3 Gene

  1. Human RanBP3, a group of nuclear RanGTP binding proteins. (PMID: 9637251) Mueller L. … Ponstingl H. (FEBS Lett. 1998) 2 3 4 23 67
  2. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PMID: 14612415) Hakata Y. … Shida H. (Mol. Cell. Biol. 2003) 3 23
  3. Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PMID: 11932251) Nemergut M.E. … Macara I.G. (J. Biol. Chem. 2002) 3 23
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for RANBP3 Gene

Sources for RANBP3 Gene

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