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RANBP3 Gene

protein-coding   GIFtS: 62
GCID: GC19M005916

RAN Binding Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAN Binding Protein 31 2
Ran-Binding Protein 32
RAN-Binding Protein-32
RanBP33

External Ids:    HGNC: 98501   Entrez Gene: 84982   Ensembl: ENSG000000318237   OMIM: 6033275   UniProtKB: Q9H6Z43   

Export aliases for RANBP3 gene to outside databases

Previous GC identifers: GC19M006008 GC19M005856 GC19M005867 GC19M005675


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RANBP3 Gene:
This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein
plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants,
encoding different isoforms, have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for RANBP3 Gene:
RANBP3 (RAN binding protein 3) is a protein-coding gene. GO annotations related to this gene include R-SMAD binding and Ran GTPase binding. An important paralog of this gene is RANBP3L.

UniProtKB/Swiss-Prot: RANB3_HUMAN, Q9H6Z4
Function: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein.
Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding
of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange
activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta
signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export

Gene Wiki entry for RANBP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RANBP3 gene promoter:
         COUP-TF1   COUP-TF   COUP   HNF-4alpha2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP3 promoter sequence
   Search Chromatin IP Primers for RANBP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANBP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

RANBP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005916:  view genomic region     (about GC identifiers)

Start:
5,916,150 bp from pter      End:
5,978,320 bp from pter
Size:
62,171 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RANB3_HUMAN, Q9H6Z4 (See protein sequence)
Recommended Name: Ran-binding protein 3  
Size: 567 amino acids; 60210 Da
Subunit: Interacts with CHC1 in a Ran-stimulated manner. Interacts with XPO1. Interacts (via its C-terminal R
domain) with SMAD2 (dephosphorylated form via its MH1 and MH2 domains); the interaction results in the nuclear
export of SMAD2 and termination of the TGF-beta signaling. Interacts (via its C-terminal R domain) with SMAD3
(dephosphorylated form via its MH1 domain); the interaction results in the nuclear export of SMAD3 and
termination of the TGF-beta signaling
Sequence caution: Sequence=AAH04349.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Sequence=CAB43293.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for RANBP3:
2CRF (3D)        2Y8F (3D)        2Y8G (3D)    
Secondary accessions: B2RAT8 O60405 O75759 O75760 Q9BT47 Q9UG74
Alternative splicing: 3 isoforms:  Q9H6Z4-1   Q9H6Z4-2   Q9H6Z4-3   

Explore the universe of human proteins at neXtProt for RANBP3: NX_Q9H6Z4

Explore proteomics data for RANBP3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys413
  • Modification sites at PhosphoSitePlus

  • See RANBP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_003615.2  NP_015559.2  NP_015561.1  

    ENSEMBL proteins: 
     ENSP00000404837   ENSP00000341483   ENSP00000466879   ENSP00000465085   ENSP00000034275  
     ENSP00000464774   ENSP00000468815   ENSP00000466510   ENSP00000466761   ENSP00000465336  
     ENSP00000468211   ENSP00000466970   ENSP00000464705   ENSP00000467760   ENSP00000464986  
     ENSP00000467560   ENSP00000466638   ENSP00000445071  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000156 Ran_bind_dom
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H6Z4

    ProtoNet protein and cluster: Q9H6Z4

    1 Blocks protein domain: IPB000156 RanBP1 domain

    UniProtKB/Swiss-Prot: RANB3_HUMAN, Q9H6Z4
    Similarity: Contains 1 RanBD1 domain


    Find genes that share domains with RANBP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RANB3_HUMAN, Q9H6Z4
    Function: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein.
    Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding
    of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange
    activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta
    signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export

         Genatlas biochemistry entry for RANBP3:
    RAN binding protein 3,localized in the nucleus,nuclear effector of the RAN pathway,preferentially bound to
    importin alpha 3

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11932251
    GO:0008536Ran GTPase binding TAS9637251
    GO:0070412R-SMAD binding IPI19289081
         
    Find genes that share ontologies with RANBP3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RANBP3:
     Increased G2M DNA content  Nuclear pre-40S maturation def 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RANBP3

    miRNA
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    miRTarBase miRNAs that target RANBP3:
    hsa-mir-455-3p (MIRT037884), hsa-mir-192-5p (MIRT004172)

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    Selected qRT-PCR Assays for microRNAs that regulate RANBP3 (see all 35):
    hsa-miR-15a hsa-miR-218-1* hsa-miR-424 hsa-miR-330-3p hsa-miR-497* hsa-miR-15b hsa-miR-181b hsa-miR-455-5p
    SwitchGear 3'UTR luciferase reporter plasmidRANBP3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RANB3_HUMAN, Q9H6Z4: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with RANBP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RANBP3 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK targets/ Nuclear events mediated by MAP kinases
    MAP Kinase Signaling0.31
    2PI3K / Akt Signaling
    PI3K / Akt Signaling
    3HTLV-I infection
    HTLV-I infection
    4Cytoskeletal Signaling
    Cytoskeletal Signaling
    5Canonical Wnt signaling pathway
    Canonical Wnt signaling pathway


    Find genes that share SuperPaths with RANBP3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for RANBP3
        MAP Kinase Signaling
    Cytoskeletal Signaling
    PI3K / Akt Signaling

    1 BioSystems Pathway for RANBP3
        Canonical Wnt signaling pathway



    1 Kegg Pathway  (Kegg details for RANBP3):
        HTLV-I infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RANBP3
    Interactions:

        GeneGlobe Interaction Network for RANBP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RANBP3 (Q9H6Z41, 2, 3 ENSP000003414834) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1AP358131, 2, ENSP000003272554EBI-992681,EBI-989143 MINT-8302849 MINT-8302864 MINT-8302886 MINT-8302912 STRING: ENSP00000327255
    SMAD2Q157961, 2, ENSP000002621604EBI-992681,EBI-1040141 MINT-8303634 MINT-8302942 MINT-8302955 STRING: ENSP00000262160
    RCC1P187541, 3, ENSP000003629374EBI-992681,EBI-992720 I2D: score=4 STRING: ENSP00000362937
    RANP628263, ENSP000003961274I2D: score=4 STRING: ENSP00000396127
    BSGP356133, ENSP000003337694I2D: score=2 STRING: ENSP00000333769
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015031protein transport IEA--
    GO:0046907intracellular transport IEA--

    Find genes that share ontologies with RANBP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for RANBP3 (RANB3)

    3 HMDB Compounds for RANBP3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RANBP3 gene (4 alternative transcripts): 
    NM_003624.2  NM_007320.2  NM_007322.2  NM_007321.1  

    Unigene Cluster for RANBP3:

    RAN binding protein 3
    Hs.531752  [show with all ESTs]
    Unigene Representative Sequence: NM_007322
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000439268(uc002mdx.3) ENST00000340578(uc002mdw.3) ENST00000592771
    ENST00000586344 ENST00000591092 ENST00000034275(uc002mdv.3 uc002mdy.3 uc002mdz.3 uc010duq.3 uc010xix.2)
    ENST00000587479 ENST00000592197 ENST00000587411 ENST00000592621 ENST00000587799
    ENST00000590623 ENST00000591736 ENST00000593025 ENST00000590953 ENST00000588879
    ENST00000587159 ENST00000586117
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    hsa-miR-15a hsa-miR-218-1* hsa-miR-424 hsa-miR-330-3p hsa-miR-497* hsa-miR-15b hsa-miR-181b hsa-miR-455-5p
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    Additional mRNA sequence: 

    AK025300.1 AK222813.1 AK222990.1 AK299260.1 AK299856.1 AK301942.1 AK308205.1 AK314343.1 
    AL050149.1 BC004349.1 DQ234346.1 Y08697.1 Y08698.1 

    Selected DOTS entries (see all 29):

    DT.97760083  DT.312821  DT.115050  DT.100819240  DT.100819250  DT.121422834  DT.100819247  DT.100819243 
    DT.100819236  DT.121422661  DT.92417407  DT.100819239  DT.95179246  DT.100762281  DT.100819238  DT.102831121 
    DT.121422868  DT.121422618  DT.91749768  DT.91749772  DT.91793754  DT.99989646  DT.100819249  DT.100834809 

    Selected AceView cDNA sequences (see all 387):

    BI830330 BQ440067 BC004349 CF125281 BU631323 AW770120 CR593954 AK025300 
    AL050149 BU902634 BF514159 CO395436 BQ637235 BM786367 BF343274 AI439055 
    BF438355 BU146713 CB853330 BM752717 AA766014 BG152533 BQ924709 BM905208 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RANBP3 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^
    SP1:                    -                             -     -     -           -                       -                                                     -   
    SP2:                    -                             -     -     -           -                 -     -                                                     -   
    SP3:                                                                          -                 -     -                                                     -   
    SP4:                    -           -                 -     -     -           -                       -                                                         
    SP5:                                                                                                  -                                                         

    ExUns: 17a · 17b ^ 18 ^ 19a · 19b · 19c
    SP1:        -                           
    SP2:        -                           
    SP3:        -                           
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for RANBP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RANBP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTTGGAA
    RANBP3 Expression
    About this image


    RANBP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Brain (Nervous System)
             Lateral Ventricle
    RANBP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RANBP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531752

    UniProtKB/Swiss-Prot: RANB3_HUMAN, Q9H6Z4
    Tissue specificity: Widely expressed with high levels in testis and heart

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RANBP3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp31 , 5 RAN binding protein 31, 5 79.15(n)1
    80.29(a)1
      17 (29.45 cM)5
    718101  NM_001252466.11  NP_001239395.11 
     566732255 
    chicken
    (Gallus gallus)
    Aves RANBP36
    RAN binding protein 3
    78(a)
    1 ↔ 1
    28(746840-778361)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.120302 Xenopus laevis transcribed sequence with moderate similarity more 77.91(n)    BU910298.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc663852 hypothetical protein MGC66385 80.21(n)   393663  BC059200.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RanBP36
    Ran binding protein 3
    26(a)
    1 → many
    3R(19576659-19578552)
    worm
    (Caenorhabditis elegans)
    Secernentea ran-56
    Protein RAN-5 (ran-5) mRNA, complete cds
    24(a)
    1 → many
    II(6048109-6049694) WBGene00004306


    ENSEMBL Gene Tree for RANBP3 (if available)
    TreeFam Gene Tree for RANBP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RANBP3 gene
    RANBP3L2  
    11 SIMAP similar genes for RANBP3 using alignment to 18 protein entries:     RANB3_HUMAN (see all proteins):
    ranbp3    FAM175A    RPL27A    COPS7B    FP1523    MEF2BNB
    TMEM145    NDUFA7    TBC1D22A    C19orf82    RANBP3L

    Find genes that share paralogs with RANBP3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RANBP3 (see all 1305)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs126098211,2
    H--5916887(+) GGAACC/TTGGGG 3 -- ut310--------
    rs1168761561,2
    C,F--5917080(+) GGAAAT/CGAAGA 3 -- ut312Minor allele frequency- C:0.01NA EU 529
    rs1835467321,2
    C--5917102(+) AGCACA/G/TTCCAA 6 -- ut311EU 459
    rs1890536811,2
    --5917473(+) TTGAAA/CAGGAC 3 -- ut310--------
    rs48070581,2
    C--5917616(+) CTCCCA/GGCCGC 3 -- ut31 ese30--------
    rs358951001,2
    C--5917644(-) GGGACG/AGGCAG 6 /R /G mis11Minor allele frequency- A:0.01NA 72
    rs104073691,2
    C,F--5917734(+) CCAGGA/TGATCA 3 -- int11Minor allele frequency- T:0.09WA 118
    rs37456321,2
    C,F,H--5917779(-) CCTGGG/CGGGGA 3 -- int15Minor allele frequency- C:0.01EA NS 1160
    rs1917127631,2
    C--5917854(+) CTGTCA/GTCCTC 6 D syn10--------
    rs1836010241,2
    --5917862(+) CTCCTC/TGTTGG 6 K E mis10--------

    HapMap Linkage Disequilibrium report for RANBP3 (5916150 - 5978320 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RANBP3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910905CNV Loss21882294
    nsv910904CNV Loss21882294
    nsv910907CNV Loss21882294
    dgv3693n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603327    OMIM disorders: --


    Find genes that share disorders with RANBP3           About GenesLikeMe


    Export disorders for RANBP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RANBP3 gene, integrated from 10 sources (see all 41):
    (articles sorted by number of sources associating them with RANBP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human RanBP3, a group of nuclear RanGTP binding proteins. (PubMed id 9637251)1, 2, 3, 9 Mueller L.... Ponstingl H. (FEBS Lett. 1998)
    2. Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. (PubMed id 11932251)1, 2, 9 Nemergut M.E.... Macara I.G. (J. Biol. Chem. 2002)
    3. Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling. (PubMed id 19289081)1, 2 Dai F.... Feng X.H. (Dev. Cell 2009)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. (PubMed id 11425870)1, 2 Lindsay M.E.... Macara I.G. (J. Cell Biol. 2001)
    9. RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. (PubMed id 11571268)1, 2 Englmeier L....Kutay U. (EMBO Rep. 2001)
    10. A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. (PubMed id 14612415)1, 9 Hakata Y.... Shida H. (Mol. Cell. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8498 HGNC: 9850 AceView: RANBP3 Ensembl:ENSG00000031823 euGenes: HUgn8498
    ECgene: RANBP3 Kegg: 8498 H-InvDB: RANBP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RANBP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RANBP3 gene:
    Search GeneIP for patents involving RANBP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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