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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RANBP2 Gene

protein-coding GIFtS: 67
GCID: GC02P109335

RAN binding protein 2

Explore 13 diseases affiliated with
RANBP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAN Binding Protein 2¹ ²		TRP1²
NUP358¹ ² ³ ⁵		TRP2²
Nuclear Pore Complex Protein Nup358² ³		E3 SUMO-Protein Ligase RanBP2²
Nucleoporin Nup358² ³		Nucleoporin 358²
Ran-Binding Protein 2² ³		Transformation-Related Protein 2²
358 KDa Nucleoporin² ³		EC 6.3.2.-³
ANE1² ⁵		RanBP2³
IIAE3²		P270²
P270²		EC 5.2.1.8⁸

External Ids:	HGNC: 9848¹	Entrez Gene: 5903²	Ensembl: ENSG00000153201⁷	OMIM: 601181⁵	UniProtKB: P49792³

Export aliases for RANBP2 gene to outside databases

Previous GC identifers: GC02P107241 GC02P107814 GC02P108911 GC02P108957 GC02P108794 GC02P108702 GC02P102934

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RANBP2:

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought

to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very

large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic

cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2

enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation

at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and

nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for

recombination on chromosome 2q. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792

Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor

(Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for

substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export

pathway. Specific docking site for the nuclear export factor exportin-1

Gene Wiki entry for RANBP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022171.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RANBP2 gene promoter:
c-Fos Tal-1 AP-1 Pax-5 p53 POU3F1 Nkx2-5 E47 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RANBP2 promoter sequence

Search SABiosciences Chromatin IP Primers for RANBP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANBP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.3 Ensembl cytogenetic band: 2q12.3 HGNC cytogenetic band: 2q13

RANBP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP2 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P109335: view genomic region (about GC identifiers)

Start:	109,335,937 bp from pter	End:	109,402,267 bp from pter
Size:	66,331 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792 (See protein sequence)

Recommended Name: E3 SUMO-protein ligase RanBP2

Size: 3224 amino acids; 358199 Da

Subunit: Forms a tight complex with RANBP1 and UBE2I. Interacts with SUMO1 but not SUMO2. Interacts with PARK2.

Interacts with sumoylated RANGAP1. Interacts with CDCA8

Subcellular location: Nucleus, nuclear pore complex. Note=Cytoplasmic filaments

6/8 PDB 3D structures from and Proteopedia for RANBP2 (see all 8):

1RRP (3D)

1XKE (3D)

1Z5S (3D)

3UIN (3D)

3UIO (3D)

3UIP (3D)

Secondary accessions: Q13074 Q15280 Q53TE2 Q59FH7

Explore the universe of human proteins at neXtProt for RANBP2: NX_P49792

Post-translational modifications:

Polyubiquitinated by PARK2, which leads to proteasomal degradation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49792

4/6 DME Specific Peptides for RANBP2 (P49792) (see all 6)

LCTGEKG

PRTAENF

KFEDENF

GLLSMAN

RANBP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006258.3

ENSEMBL proteins:

ENSP00000387272 ENSP00000283195 ENSP00000398970 ENSP00000410745

Reactome Protein details: P49792
Human Recombinant Protein Products:

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	Uscn Proteins for RANBP2

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005643	nuclear pore	IDA	17098863
GO:0005829	cytosol	TAS	--
GO:0031965	nuclear membrane	IDA	11839768
GO:0042405	nuclear inclusion body	IDA	11839768

RANBP2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for RANBP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RANBP2 for domains About GeneDecksing

5/10 InterPro domains/families (see all 10):

IPR000156 Ran_bind_dom

IPR011990 TPR-like_helical

IPR002130 Cyclophilin-like_PPIase_dom

IPR011993 PH_like_dom

IPR001440 TPR-1

Graphical View of Domain Structure for InterPro Entry P49792

ProtoNet protein and cluster: P49792

3 Blocks protein families:

IPB000156 RanBP1 domain

IPB001876 Zn-finger

IPB002130 Peptidyl-prolyl cis-trans isomerase

UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792

Domain: Contains F-X-F-G repeats

Similarity: Contains 1 PPIase cyclophilin-type domain

Similarity: Contains 4 RanBD1 domains

Similarity: Contains 8 RanBP2-type zinc fingers

Similarity: Contains 1 TPR repeat

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792

Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor

(Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for

substrates. Could also have isomerase or chaperone activity and may bind RNA or DNA. Component of the nuclear export

pathway. Specific docking site for the nuclear export factor exportin-1

Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0)

Genatlas biochemistry entry for RANBP2:

Ran (Ras-related small nuclear protein)component of the nuclear pore complex (NPC),involved in cell-cycle

progression,nucleocytoplasmic transport,pre-mRNA processing

Enzyme Numbers (IUBMB): EC 6.3.2.-¹ EC 5.2.1.8²

miRNA Products:		OriGene 3'-UTR Clone: RANBP2 Browse MicroRNA Expression Plasmids
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		8/63 QIAGEN miScript miRNA Assays for microRNAs that regulate RANBP2 (see all 63):
		hsa-miR-142-5p hsa-miR-549 hsa-miR-100* hsa-miR-607 hsa-let-7d hsa-miR-411 hsa-miR-4272 hsa-miR-3074-3p

		SwitchGear 3'UTR luciferase reporter plasmid: RANBP2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP2

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA	--
GO:0005515	protein binding	IPI	16332688
GO:0008270	zinc ion binding	IEA	--
GO:0008536	Ran GTPase binding	TAS	7603572
GO:0016874	ligase activity	IEA	--

RANBP2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for RANBP2:

Decreased DCP1a protein expres	Decreased p24 protein expressi	Decreased viability of wild-ty	Nuclear 40S maturation defects
Nuclear pre-40S maturation def

Animal Models:
Mouse knock-out Ranbp2^tm1.1Jvd for RANBP2
7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ranbp2):

cellular	growth/size	homeostasis/metabolism	mortality/aging	nervous system
tumorigenesis	vision/eye

RANBP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/21 super-pathways (see all 21) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

8/11 pathways (see all 11)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00	Interactions of Vpr with host cellular proteins	0.70
Nuclear import of Rev protein	0.76	Glucose transport	0.57
Vpr-mediated nuclear import of PICs	0.76	Hexose transport	0.55
Regulation of Glucokinase by Glucokinase Regulatory Protein	0.75	ISG15 antiviral mechanism	0.49

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Transcription_P53 signaling pathway

Transcription_P53 signaling pathway

1.00

Transcription P53 signaling pathway

0.98

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for RANBP2

	Proteolysis Putative SUMO-1 pathway
	DNA damage Role of SUMO in p53 regulation
	Transcription P53 signaling pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RANBP2

	Ran Pathway
	SUMO Pathway

3 GeneGo (Thomson Reuters) Pathways for RANBP2

	Proteolysis Putative SUMO-1 pathway
	Transcription P53 signaling pathway
	DNA damage Role of SUMO in p53 regulation

3 BioSystems Pathways for RANBP2

	Sumoylation by RanBP2 regulates transcriptional repression
	Signaling events mediated by HDAC Class I
	Signaling events mediated by HDAC Class II

5/33 Reactome Pathways for RANBP2 (see all 33)

	Mitotic Prometaphase
	Interactions of Rev with host cellular proteins
	Rev-mediated nuclear export of HIV-1 RNA
	Interferon Signaling
	Vpr-mediated nuclear import of PICs

1 Kegg Pathway (Kegg details for RANBP2):

RNA transport

UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792

Pathway: Protein modification; protein sumoylation

RANBP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RANBP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/842 Interacting proteins for RANBP2 (P49792^{1, 2, 3} ENSP00000283195⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 842)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RANGAP1	P46060²^,³, ENSP00000348577⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000348577
PARK2	O60260¹^,³, ENSP00000355865⁴	EBI-973138,EBI-716346 I2D: score=3 STRING: ENSP00000355865
MVP	Q14764²^,³	MINT-7945693 MINT-7947479 I2D: score=2
NUP62	P37198²^,³, ENSP00000305503⁴	MINT-4301750 I2D: score=2 STRING: ENSP00000305503
PLEC	Q15149²^,³	MINT-7945693 MINT-7947479 I2D: score=2

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006457	protein folding	IEA	--

RANBP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RANBP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RANBP2

1 HMDB Compound for RANBP2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

4 Novoseek chemical compound relationships for RANBP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gppnhp	54.5	1	10078529 (1)
leptomycin b	54.4	1	10601307 (1)
gtp	51.6	9	7593180 (2), 10995230 (2), 10078529 (1), 9398678 (1) (see all 5)
zinc	5.08	8	10601307 (5), 11553612 (1), 8603673 (1)

Search CenterWatch for drugs/clinical trials and news about RANBP2 / RBP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RANBP2 gene:

NM_006267.4

Unigene Cluster for RANBP2:

RAN binding protein 2

Hs.199561 [show with all ESTs]

Unigene Representative Sequence: NM_006267

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409491 ENST00000283195(uc002tem.4) ENST00000425282 ENST00000456637

ENST00000495924 ENST00000495506

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		SwitchGear 3'UTR luciferase reporter plasmid: RANBP2 3' UTR sequence

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Additional cDNA sequence:

AB209483.1 AK025462.1 AK025711.1 AK026993.1 AY170822.1 D42063.1 U19240.1 U19248.1

24/26 DOTS entries (see all 26):

DT.87078957 DT.95274711 DT.95149140 DT.414030 DT.120953339 DT.92035289 DT.100827367 DT.120953361

DT.101966955 DT.100827358 DT.120953345 DT.95079887 DT.95274712 DT.100763923 DT.120953300 DT.120953310

DT.120953369 DT.91655752 DT.92453559 DT.95274705 DT.99958483 DT.120933593 DT.120953368 DT.120954986

24/336 AceView cDNA sequences (see all 336):

CB215465 BX641813 BI793271 CB141267 CB137193 BP342581 CA395344 CD722329

R27450 AW450127 AK025711 AA211395 AA683138 BP342576 BE645282 AI432203

BM311301 AA258798 AI478813 AA258494 Z41403 AA258330 AI889632 AI674244

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RANBP2 (see all 6) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16a	·	16b	·	16c	^	17	^	18a	·	18b	^	19
SP1:																									-						-		-
SP2:																									-								-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RANBP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RANBP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGAAATA

About this image

RANBP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RANBP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RANBP2

SOURCE GeneReport for Unigene cluster: Hs.199561

SABiosciences Expression via Pathway-Focused PCR Array including RANBP2:

Ubiquitin Ligases in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP2 gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RANBP2¹	RAN binding protein 2	69.44(n) 67.65(a)		418730 XM_416929.3 XP_416929.3
lizard (Anolis carolinensis)	Reptilia	--	--	67(a)	1 → many	3(107456143-107504239)
African clawed frog (Xenopus laevis)	Amphibia	Xl.7285²	Xenopus laevis transcribed sequence with weak similarity more	75.67(n)		BX845252.1
zebrafish (Danio rerio)	Actinopterygii	Dr.29687²	Transcribed sequence with weak similarity to protein more	70.64(n)		BQ449922.1
fruit fly (Drosophila melanogaster)	Insecta	Cyp1³ Nup358¹	protein folding cyclin-dependent protein kinase, more³ Nucleoporin 358¹	66(a)³ 42.34(n)¹ 30.92(a)¹		14B12³ 43041¹ NM_143104.2¹ NP_651361.2¹
worm (Caenorhabditis elegans)	Secernentea	npp-9⁶	Nuclear Pore complex Protein family member (npp-9)...	17(a)	1 → many	III(3400630-3404468)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G30060⁶ RANBP1⁶ (see all 3)	Ran-binding protein 1-c (see all 3)	30(a) 28(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(12826915-12828919) 5(23680079-23681798)
rice (Oryza sativa)	Liliopsida	-- --	ranBP1 domain containing protein, expressed	33(a) 31(a)	many ↔ many many ↔ many	5(16502227-16505012) 3(10186345-10189247)

ENSEMBL Gene Tree for RANBP2 (if available)
TreeFam Gene Tree for RANBP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RANBP2 gene

RGPD2² RGPD4² RGPD6² RGPD3² RGPD1² RANBP1² RGPD8² RGPD5²

18/26 SIMAP similar genes for RANBP2 using alignment to 4 protein entries: RBP2_HUMAN (see all proteins) (see all similar genes):

RGPD5 PPIF RGPD6 PPIA LOC402252 RGPD8

RGPD1 PPIAL4A PPIAL4B PPIAL4C PPIAL4G RGPD3

RGPD4 RGPD2 PPIE PPIB PPIC PPIH

RANBP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs10208578^1,2	C,	--	102968310(+)	`tatttA/Tttatt`	1	--	int¹		0	--	--	--	--
rs62151254^1,2		--	102968470(+)	`CCAAGC/ATAAAA`	1	--	int¹		2		NA	122
rs13429944^1,2	C,	--	102968472(+)	`aaGCTA/GAAAGT`	1	--	int¹		0	--	--	--	--
rs9941631^1,2	C,	--	102968514(+)	`AAGCAC/TTATTT`	1	--	int¹		1		NA	2
rs1043054^1,2	C	--	102968605(+)	`TCTGAC/GAAAGA`	2	T R	mis¹		0	--	--	--	--
rs2556287^1,2	C	--	102968617(-)	`GGTAGC/TCCCTG`	2	D G	mis¹		0	--	--	--	--
rs2693128^1,2	C	--	102968634(+)	`AGATTA/TTAGAT`	2	I L	mis¹		0	--	--	--	--
rs10185559^1,2	C,H	--	102968809(+)	`TGTGTC/GTAAAT`	1	--	int¹		4		NS EA	418
rs2557917^1,2		--	102969065(-)	`GTTCAC/TAATGG`	1	--	int¹		1		NA	2
rs17021308^1,2	C,F,H,	--	102969398(+)	`AAAAAA/GTATAA`	1	--	int¹ trp³		8		NA NS EA WA	678

HapMap Linkage Disequilibrium report for RANBP2 (109335937 - 109402267 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RANBP2: --
Human Gene Mutation Database (HGMD): RANBP2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RANBP2

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RANBP2 for disorders           About GeneDecksing

OMIM gene information: 601181
OMIM disorders: 608033
UniProtKB/Swiss-Prot: RBP2_HUMAN, P49792

Defects in RANBP2 are the cause of encephalopathy acute infection-induced type 3 (IIAE3) [MIM:608033]. A

rapidly progressive encephalopathy manifesting in susceptibile individuals with seizures and coma. It can occur within

days in otherwise healthy children after common viral infections such as influenza and parainfluenza, without evidence

of viral infection of the brain or inflammatory cell infiltration. Brain T2-weighted magnetic resonance imaging

reveals characteristic symmetric lesions present in the thalami, pons and brainstem. Note=Mutations in the RANBP2 gene

predispose to IIAE3, but by themselves are insufficient to make the phenotype fully penetrant; additional genetic and

environmental factors are required (PubMed:19118815)

13 diseases for RANBP2: About MalaCards

encephalopathy, acute necrotizing 1 inflammatory myofibroblastic tumor multiple myeloma uveitis

myeloma influenza melanoma astrocytoma

lung cancer immunodeficiency hepatitis prostatitis

neuronitis

2 Novoseek disease relationships for RANBP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	3	18394551 (1), 18701132 (1)
melanoma	0	2	15980237 (1)

Human Genome Epidemiology (HuGE) Navigator: RANBP2 (1 document)

Export disorders for RANBP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RANBP2 gene, integrated from 9 sources (see all 158):
(articles sorted by number of sources associating them with RANBP2)

Utopia: connect your pdf to the dynamic
world of online information

The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif. (PubMed id 7724562)^{1, 2, 3} Beddow A.L.... Macara I.G. (1995)
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. (PubMed id 15608651)^{1, 2, 9} Tatham M.H.... Hay R.T. (2005)
Parkin ubiquitinates and promotes the degradation of RanBP2. (PubMed id 16332688)^{1, 2, 9} Um J.W.... Chung K.C. (2006)
Solution structure of the Ran-binding domain 2 of RanBP2 and its interaction with the C terminus of Ran. (PubMed id 15826666)^{1, 2, 9} Geyer J.P.... Kalbitzer H.R. (2005)
A giant nucleopore protein that binds Ran/TC4. (PubMed id 7603572)^{1, 2, 9} Yokoyama N.... Aebi U. (1995)
The nucleoporin RanBP2 has SUMO1 E3 ligase activity. (PubMed id 11792325)^{1, 2, 9} Pichler A.... Melchior F. (2002)
Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. (PubMed id 10078529)^{1, 2, 9} Vetter I.R.... Wittinghofer A. (1999)
Infection-triggered familial or recurrent cases of acute necrotizing encephalopathy caused by mutations in a component of the nuclear pore, RANBP2. (PubMed id 19118815)^{1, 2, 9} Neilson D.E.... Warman M.L. (2009)
RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation- deconjugation cycle on Borealin. (PubMed id 18946085)^{1, 2} Klein U.R.... Muller S. (2009)
A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers. (PubMed id 16620772)^{1, 2} Li T....Chock P.B. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5903	HGNC: 9848	AceView: RANBP2	Ensembl:ENSG00000153201	euGenes: HUgn5903
ECgene: RANBP2	Kegg: 5903	H-InvDB: RANBP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RANBP2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RANBP2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RANBP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RANBP2 gene:
Search GeneIP for patents involving RANBP2

GeneCards and IP:
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