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Aliases for RANBP17 Gene

Aliases for RANBP17 Gene

  • RAN Binding Protein 17 2 3 5

External Ids for RANBP17 Gene

Previous GeneCards Identifiers for RANBP17 Gene

  • GC05P170523
  • GC05P170991
  • GC05P170224
  • GC05P170270
  • GC05P170271
  • GC05P170237
  • GC05P170221
  • GC05P165386

Summaries for RANBP17 Gene

Entrez Gene Summary for RANBP17 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for RANBP17 Gene

RANBP17 (RAN Binding Protein 17) is a Protein Coding gene. GO annotations related to this gene include GTP binding and Ran GTPase binding. An important paralog of this gene is XPO7.

UniProtKB/Swiss-Prot for RANBP17 Gene

  • May function as a nuclear transport receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP17 Gene

Genomics for RANBP17 Gene

Regulatory Elements for RANBP17 Gene

Enhancers for RANBP17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RANBP17 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANBP17 on UCSC Golden Path with GeneCards custom track

Genomic Location for RANBP17 Gene

170,861,870 bp from pter
171,300,450 bp from pter
438,581 bases
Plus strand

Genomic View for RANBP17 Gene

Genes around RANBP17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP17 Gene

Proteins for RANBP17 Gene

  • Protein details for RANBP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ran-binding protein 17
    Protein Accession:
    Secondary Accessions:
    • Q8IU74

    Protein attributes for RANBP17 Gene

    1088 amino acids
    Molecular mass:
    124375 Da
    Quaternary structure:
    • Binds to nucleoporins and the GTP-bound form of Ran.
    • Sequence=BAB55427.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP17 Gene


neXtProt entry for RANBP17 Gene

Proteomics data for RANBP17 Gene at MOPED

Post-translational modifications for RANBP17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP17 Gene

Domains & Families for RANBP17 Gene

Protein Domains for RANBP17 Gene

Suggested Antigen Peptide Sequences for RANBP17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the exportin family.
  • Belongs to the exportin family.
genes like me logo Genes that share domains with RANBP17: view

No data available for Gene Families for RANBP17 Gene

Function for RANBP17 Gene

Molecular function for RANBP17 Gene

UniProtKB/Swiss-Prot Function:
May function as a nuclear transport receptor.

Gene Ontology (GO) - Molecular Function for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding IEA --
genes like me logo Genes that share ontologies with RANBP17: view

Phenotypes for RANBP17 Gene

GenomeRNAi human phenotypes for RANBP17:
genes like me logo Genes that share phenotypes with RANBP17: view

Animal Model Products

miRNA for RANBP17 Gene

miRTarBase miRNAs that target RANBP17

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP17 Gene

Localization for RANBP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP17 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex.

Subcellular locations from

Jensen Localization Image for RANBP17 Gene COMPARTMENTS Subcellular localization image for RANBP17 gene
Compartment Confidence
nucleus 5
cytosol 3
lysosome 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with RANBP17: view

Pathways & Interactions for RANBP17 Gene

SuperPathways for RANBP17 Gene

No Data Available

Interacting Proteins for RANBP17 Gene

SIGNOR curated interactions for RANBP17 Gene


Gene Ontology (GO) - Biological Process for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus NAS 11024021
GO:0006611 protein export from nucleus IBA --
genes like me logo Genes that share ontologies with RANBP17: view

No data available for Pathways by source for RANBP17 Gene

Drugs & Compounds for RANBP17 Gene

(1) Drugs for RANBP17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANBP17: view

Transcripts for RANBP17 Gene

Unigene Clusters for RANBP17 Gene

RAN binding protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP17 Gene

No ASD Table

Relevant External Links for RANBP17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RANBP17 Gene

mRNA expression in normal human tissues for RANBP17 Gene

mRNA differential expression in normal tissues according to GTEx for RANBP17 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for RANBP17 Gene

This gene is overexpressed in Testis (41.2) and Brain (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP17 Gene

SOURCE GeneReport for Unigene cluster for RANBP17 Gene Hs.410810

mRNA Expression by UniProt/SwissProt for RANBP17 Gene

Tissue specificity: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.
genes like me logo Genes that share expression patterns with RANBP17: view

Protein tissue co-expression partners for RANBP17 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RANBP17 Gene

Orthologs for RANBP17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RANBP17 35
  • 93.85 (n)
  • 95.42 (a)
RANBP17 36
  • 94 (a)
(Canis familiaris)
Mammalia RANBP17 35
  • 94.39 (n)
  • 96.32 (a)
RANBP17 36
  • 96 (a)
(Mus musculus)
Mammalia Ranbp17 35
  • 89.98 (n)
  • 93.75 (a)
Ranbp17 16
Ranbp17 36
  • 94 (a)
(Pan troglodytes)
Mammalia RANBP17 35
  • 99.63 (n)
  • 99.45 (a)
RANBP17 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ranbp17 35
  • 90.2 (n)
  • 94.3 (a)
(Monodelphis domestica)
Mammalia RANBP17 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia RANBP17 36
  • 89 (a)
(Gallus gallus)
Aves LOC769940 35
  • 76.94 (n)
  • 74.04 (a)
RANBP17 36
  • 72 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 80 (a)
-- 36
  • 84 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ranbp16 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea C35A5.8 37
  • 40 (a)
C35A5.8 36
  • 40 (a)
(Triticum aestivum)
Liliopsida Ta.23305 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
Species with no ortholog for RANBP17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • zebrafish (Danio rerio)

Evolution for RANBP17 Gene

Gene Tree for RANBP17 (if available)
Gene Tree for RANBP17 (if available)

Paralogs for RANBP17 Gene

Paralogs for RANBP17 Gene

(2) SIMAP similar genes for RANBP17 Gene using alignment to 9 proteins: Pseudogenes for RANBP17 Gene

genes like me logo Genes that share paralogs with RANBP17: view

Variants for RANBP17 Gene

Sequence variations from dbSNP and Humsavar for RANBP17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs715225 -- 171,263,004(+) GTGAG(C/T)TTTTA intron-variant
rs765052 -- 170,972,592(-) aatGT(A/G)TAATG intron-variant
rs779640 -- 171,047,997(+) TTTAT(A/G)CAAGT intron-variant
rs779641 -- 171,053,115(+) gtgcc(C/T)ggcca intron-variant
rs779645 -- 171,057,990(+) GGAGA(A/T)ACATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP17 Gene

Variant ID Type Subtype PubMed ID
nsv520782 CNV Gain 19592680
nsv5129 CNV Loss 18451855
esv2731086 CNV Deletion 23290073
nsv328840 CNV Loss 16902084
esv1010423 CNV Deletion 20482838
esv1782186 CNV Deletion 17803354
esv2731087 CNV Deletion 23290073
nsv507308 CNV Insertion 20534489
nsv830550 CNV Loss 17160897
nsv508386 CNV Loss 20534489
esv2731088 CNV Deletion 23290073
nsv525376 CNV Loss 19592680
nsv518091 CNV Loss 19592680
nsv5130 CNV Insertion 18451855
esv6863 CNV Gain 19470904
esv270865 CNV Insertion 20981092
nsv5131 CNV Loss 18451855

Variation tolerance for RANBP17 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.10% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RANBP17 Gene

Disorders for RANBP17 Gene

Relevant External Links for RANBP17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RANBP17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP17 Gene

Publications for RANBP17 Gene

  1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U. … Bischoff F.R. (J. Biol. Chem. 2000) 2 3 4 67
  2. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P. … Janssen J.W.G. (Biochem. Biophys. Res. Commun. 2000) 3 23
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for RANBP17 Gene

Sources for RANBP17 Gene