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RANBP17 Gene

protein-coding   GIFtS: 49
GCID: GC05P170221

RAN Binding Protein 17

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAN Binding Protein 171 2
Ran-Binding Protein 172

External Ids:    HGNC: 144281   Entrez Gene: 649012   Ensembl: ENSG000002047647   OMIM: 6061415   UniProtKB: Q9H2T73   

Export aliases for RANBP17 gene to outside databases

Previous GC identifers: GC05P170523 GC05P170991 GC05P170224 GC05P170270 GC05P170271 GC05P170237 GC05P165386


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RANBP17 Gene:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and
regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition
of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738.
The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a
member of the importin-beta superfamily of nuclear transport receptors.(supplied by OMIM, Jul 2002)

GeneCards Summary for RANBP17 Gene:
RANBP17 (RAN binding protein 17) is a protein-coding gene. GO annotations related to this gene include GTP binding and Ran GTPase binding. An important paralog of this gene is XPO7.

UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
Function: May function as a nuclear transport receptor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_023133.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the RANBP17 gene promoter:
         Sox5   MyoD   Nkx2-5   E47   PPAR-gamma1   HSF2   c-Myb   Sox9   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP17 promoter sequence
   Search Chromatin IP Primers for RANBP17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANBP17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q34

RANBP17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP17 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170221:  view genomic region     (about GC identifiers)

Start:
170,288,874 bp from pter      End:
170,727,019 bp from pter
Size:
438,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7 (See protein sequence)
Recommended Name: Ran-binding protein 17  
Size: 1088 amino acids; 124375 Da
Subunit: Binds to nucleoporins and the GTP-bound form of Ran (By similarity)
Sequence caution: Sequence=BAB55427.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for RANBP17: NX_Q9H2T7

Explore proteomics data for RANBP17 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RANBP17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_075048.1  
    ENSEMBL proteins: 
     ENSP00000427975   ENSP00000373770   ENSP00000429298   ENSP00000430599   ENSP00000430958  
     ENSP00000430444   ENSP00000429845   ENSP00000429609   ENSP00000430577   ENSP00000427980  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H2T7

    ProtoNet protein and cluster: Q9H2T7

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
    Similarity: Belongs to the exportin family


    Find genes that share domains with RANBP17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBP17_HUMAN, Q9H2T7
    Function: May function as a nuclear transport receptor (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005525GTP binding NAS11024021
    GO:0008536Ran GTPase binding IEA--
         
    Find genes that share ontologies with RANBP17           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for RANBP17

    miRNA
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    miRTarBase miRNAs that target RANBP17:
    hsa-mir-361-5p (MIRT044077)

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    Selected qRT-PCR Assays for microRNAs that regulate RANBP17 (see all 24):
    hsa-miR-2052 hsa-miR-34b* hsa-miR-3152-3p hsa-miR-361-5p hsa-miR-4305 hsa-miR-331-3p hsa-miR-1205 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidRANBP17 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBP17_HUMAN, Q9H2T7: Cytoplasm (By similarity). Nucleus (By similarity). Nucleus, nuclear pore complex (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    lysosome1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005643nuclear pore NAS11024021
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with RANBP17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RANBP17
    Interactions:

        Search GeneGlobe Interaction Network for RANBP17

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for RANBP17 (ENSP000003737704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCYL1ENSP000002701764STRING: ENSP00000270176
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus NAS11024021
    GO:0006886intracellular protein transport ----
    GO:0051028mRNA transport IEA--

    Find genes that share ontologies with RANBP17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RANBP17 (RBP17)

    1 HMDB Compound for RANBP17    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RANBP17 gene: 
    NM_022897.3  

    Unigene Cluster for RANBP17:

    RAN binding protein 17
    Hs.410810  [show with all ESTs]
    Unigene Representative Sequence: NM_022897
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000443155(uc011dew.2) ENST00000523189(uc003mba.3) ENST00000389118(uc003maz.2 uc010jjr.2)
    ENST00000519256(uc003may.2 uc003mbd.3) ENST00000522533(uc003mbb.3 uc010jjs.3)
    ENST00000522066(uc003max.2) ENST00000519949 ENST00000519130(uc003maw.3)
    ENST00000520864(uc003mbc.3) ENST00000519944 ENST00000523727 ENST00000522734
    ENST00000520879 ENST00000522380 ENST00000517629 ENST00000521165 ENST00000518492
    ENST00000521759
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    hsa-miR-2052 hsa-miR-34b* hsa-miR-3152-3p hsa-miR-361-5p hsa-miR-4305 hsa-miR-331-3p hsa-miR-1205 hsa-miR-29b-1*
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      QuantiFast Probe-based Assays in human, mouse, rat RANBP17

    Additional mRNA sequence: 

    AF222747.1 AJ271459.1 AK027880.1 AK057478.1 AK298785.1 BC030953.1 

    17 DOTS entries:

    DT.100745230  DT.95263514  DT.413619  DT.91673971  DT.100689054  DT.99948522  DT.100745228  DT.202605 
    DT.40128129  DT.403584  DT.99999014  DT.120831858  DT.40127766  DT.75110465  DT.92041733  DT.95100951 
    DT.100745229 

    Selected AceView cDNA sequences (see all 77):

    BX118414 AJ288954 AJ288953 AJ288952 AJ288955 BX092328 BX116784 AI383599 
    AW298009 AJ271459 BE501424 AL832980 BC030953 NM_022897 BM479853 AW964997 
    AL710618 AW469697 AA992096 AA927207 BI824159 BF593370 AK027880 AW418722 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RANBP17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RANBP17 Expression
    About this image

    RANBP17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RANBP17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410810

    UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
    Tissue specificity: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RANBP17 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp171 , 5 RAN binding protein 171, 5 89.98(n)1
    93.75(a)1
      11 (19.21 cM)5
    660111  NM_023146.21  NP_075635.11 
     332117955 
    chicken
    (Gallus gallus)
    Aves LOC7699401 ran-binding protein 17-like 76.94(n)
    74.04(a)
      769940  XM_003642068.2  XP_003642116.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    84(a)
    80(a)
    many → 1
    many → 1
    1(129961311-130164974)
    1(129935359-129992444)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp166
    Ranbp16
    53(a)
    1 → many
    X(15821218-15827707)
    worm
    (Caenorhabditis elegans)
    Secernentea C35A5.83   -- 40(a)   V(10524740-10528459)   --
    wheat
    (Triticum aestivum)
    Liliopsida Ta.233052 Triticum aestivum transcribed sequence with weak similarity more 74.56(n)    CA502227.1 


    ENSEMBL Gene Tree for RANBP17 (if available)
    TreeFam Gene Tree for RANBP17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RANBP17 gene
    XPO72  
    2 SIMAP similar genes for RANBP17 using alignment to 9 protein entries:     RBP17_HUMAN (see all proteins):
    DKFZp666P032    XPO7

    Find genes that share paralogs with RANBP17           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RANBP17
    PGOHUM00000257134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RANBP17 (see all 8307)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790828991,2
    C,F--170287040(+) TCCAAC/TGTGCT 1 -- us2k12Minor allele frequency- T:0.04NA 122
    rs1428214461,2
    --170287101(+) TGTAAA/GACCTA 1 -- us2k10--------
    rs1904658071,2
    --170287263(+) CTTCTA/GCATGG 1 -- us2k10--------
    rs591282241,2
    C--170287330(+) AAAAA-/AA/AAA
            
    GAAAG
    2 -- us2k1 cds11NA 2
    rs1827475141,2
    --170287378(+) GGAAGA/GCTCAG 1 -- us2k10--------
    rs1870333691,2
    --170287499(+) TGGGAC/GAGGAG 1 -- us2k10--------
    rs733118591,2
    C,F--170287518(+) ATGAAA/CATTTC 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs1928619501,2
    --170287523(+) AATTTC/TAACTT 1 -- us2k10--------
    rs1844204471,2
    --170287564(+) TATAAC/TTAAAA 1 -- us2k10--------
    rs1878169641,2
    --170287587(+) TAGAGA/GGGATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RANBP17 (170288874 - 170538874 bp, first 250kb of RANBP17)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RANBP17 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731088CNV Deletion23290073
    esv1782186CNV Deletion17803354
    esv2731087CNV Deletion23290073
    esv1010423CNV Deletion20482838
    esv2731086CNV Deletion23290073
    esv270865CNV Insertion20981092
    nsv507308CNV Insertion20534489
    nsv5130CNV Insertion18451855
    nsv508386CNV Loss20534489
    nsv5131CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606141    OMIM disorders: --


    Find genes that share disorders with RANBP17           About GenesLikeMe

    Genetic Association Database (GAD): RANBP17
    Human Genome Epidemiology (HuGE) Navigator: RANBP17 (3 documents)

    Export disorders for RANBP17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RANBP17 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with RANBP17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PubMed id 11024021)1, 2, 3 Kutay U.... Bischoff F.R. (J. Biol. Chem. 2000)
    2. Identification of a novel putative Ran-binding protein and its close homologue. (PubMed id 11071879)1, 2, 9 Koch P.... Janssen J.W.G. (Biochem. Biophys. Res. Commun. 2000)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. Identification of RANBP16 and RANBP17 as novel interaction partners for the bHLH transcription factor E12. (PubMed id 20503194)1 Lee J.H....Smas C.M. (J. Cell. Biochem. 2010)
    10. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64901 HGNC: 14428 AceView: RANBP17 Ensembl:ENSG00000204764 euGenes: HUgn64901
    ECgene: RANBP17 H-InvDB: RANBP17

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RANBP17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RANBP17 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for RANBP17 gene:
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