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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RANBP17 Gene

protein-coding   GIFtS: 49
GCID: GC05P170221

RAN Binding Protein 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAN Binding Protein 171 2
Ran-Binding Protein 172

External Ids:    HGNC: 144281   Entrez Gene: 649012   Ensembl: ENSG000002047647   OMIM: 6061415   UniProtKB: Q9H2T73   

Export aliases for RANBP17 gene to outside databases

Previous GC identifers: GC05P170523 GC05P170991 GC05P170224 GC05P170270 GC05P170271 GC05P170237 GC05P165386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RANBP17 Gene:
The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and
regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition
of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738.
The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a
member of the importin-beta superfamily of nuclear transport receptors.(supplied by OMIM, Jul 2002)

GeneCards Summary for RANBP17 Gene: 
RANBP17 (RAN binding protein 17) is a protein-coding gene. Diseases associated with RANBP17 include lymphoblastic leukemia, and leukemia. GO annotations related to this gene include protein transporter activity and GTP binding. An important paralog of this gene is XPO7.

UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
Function: May function as a nuclear transport receptor (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_023133.13  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RANBP17 gene promoter:
         Sox5   MyoD   Nkx2-5   E47   PPAR-gamma1   HSF2   c-Myb   Sox9   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP17 promoter sequence
   Search SABiosciences Chromatin IP Primers for RANBP17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANBP17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q34   Ensembl cytogenetic band:  5q35.1   HGNC cytogenetic band: 5q34

RANBP17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP17 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P170221:  view genomic region     (about GC identifiers)

Start:
170,288,874 bp from pter      End:
170,727,019 bp from pter
Size:
438,146 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7 (See protein sequence)
Recommended Name: Ran-binding protein 17  
Size: 1088 amino acids; 124375 Da
Subunit: Binds to nucleoporins and the GTP-bound form of Ran (By similarity)
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Nucleus, nuclear pore complex (By
similarity)
Sequence caution: Sequence=BAB55427.1; Type=Erroneous initiation;

Explore the universe of human proteins at neXtProt for RANBP17: NX_Q9H2T7

Explore proteomics data for RANBP17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H2T7

  • RANBP17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RANBP17 Protein Expression
    REFSEQ proteins: NP_075048.1  
    ENSEMBL proteins: 
     ENSP00000427975   ENSP00000373770   ENSP00000429298   ENSP00000430599   ENSP00000430958  
     ENSP00000430444   ENSP00000429845   ENSP00000429609   ENSP00000430577   ENSP00000427980  

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    Cloud-Clone Corp. Proteins for RANBP17 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005643nuclear pore NAS11024021
    GO:0005737cytoplasm IEA--

    RANBP17 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR001494 Importin-beta_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q9H2T7

    ProtoNet protein and cluster: Q9H2T7

    1 Blocks protein domain: IPB001494 Importin-beta

    UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
    Similarity: Belongs to the exportin family


    RANBP17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBP17_HUMAN, Q9H2T7
    Function: May function as a nuclear transport receptor (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005525GTP binding NAS11024021
    GO:0008536Ran GTPase binding IEA--
    GO:0008565protein transporter activity ----
         
    RANBP17 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RANBP17

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for RANBP17 (ENSP000003737704) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus NAS11024021
    GO:0006886intracellular protein transport ----
    GO:0051028mRNA transport IEA--

    RANBP17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RANBP17 (RBP17)

    1 HMDB Compound for RANBP17    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RANBP17 / RBP17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RANBP17 gene: 
    NM_022897.3  

    Unigene Cluster for RANBP17:

    RAN binding protein 17
    Hs.410810  [show with all ESTs]
    Unigene Representative Sequence: NM_022897
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000443155(uc011dew.2) ENST00000523189(uc003mba.3) ENST00000389118(uc003maz.2 uc010jjr.2)
    ENST00000519256(uc003may.2 uc003mbd.3) ENST00000522533(uc003mbb.3 uc010jjs.3)
    ENST00000522066(uc003max.2) ENST00000519949 ENST00000519130(uc003maw.3)
    ENST00000520864(uc003mbc.3) ENST00000519944 ENST00000523727 ENST00000522734
    ENST00000520879 ENST00000522380 ENST00000517629 ENST00000521165 ENST00000518492
    ENST00000521759
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    hsa-miR-2052 hsa-miR-34b* hsa-miR-3152-3p hsa-miR-361-5p hsa-miR-4305 hsa-miR-331-3p hsa-miR-1205 hsa-miR-29b-1*
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF222747.1 AJ271459.1 AK027880.1 AK057478.1 AK298785.1 BC030953.1 

    17 DOTS entries:

    DT.100745230  DT.95263514  DT.413619  DT.91673971  DT.100689054  DT.99948522  DT.100745228  DT.202605 
    DT.40128129  DT.403584  DT.99999014  DT.120831858  DT.40127766  DT.75110465  DT.92041733  DT.95100951 
    DT.100745229 

    24/77 AceView cDNA sequences (see all 77):

    NM_022897 BM479853 AJ288954 AJ288953 AJ288952 AJ288955 BX092328 BX116784 
    AI383599 AW298009 AJ271459 BE501424 AL832980 BC030953 BX118414 AF222747 
    AI250894 AI333129 BM465546 AK057478 AW469267 BU607664 AA336789 BE501439 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RANBP17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RANBP17 Expression
    About this image


    See RANBP17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RANBP17

    SOURCE GeneReport for Unigene cluster: Hs.410810

    UniProtKB/Swiss-Prot: RBP17_HUMAN, Q9H2T7
    Tissue specificity: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RANBP17 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp171 , 5 RAN binding protein 171, 5 89.98(n)1
    93.75(a)1
      11 (19.21 cM)5
    660111  NM_023146.21  NP_075635.11 
     332117955 
    chicken
    (Gallus gallus)
    Aves LOC7699401 ran-binding protein 17-like 75.43(n)
    72.07(a)
      769940  XM_003642068.1  XP_003642116.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    83(a)
    80(a)
    many → 1
    many → 1
    1(129961311-130164974)
    1(129935359-129992444)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ranbp166
    Ranbp16
    52(a)
    1 → many
    X(15821218-15827707)
    worm
    (Caenorhabditis elegans)
    Secernentea C35A5.83   -- 40(a)   V(10524740-10528459)   --
    wheat
    (Triticum aestivum)
    Liliopsida Ta.233052 Triticum aestivum transcribed sequence with weak similarity more 74.56(n)    CA502227.1 


    ENSEMBL Gene Tree for RANBP17 (if available)
    TreeFam Gene Tree for RANBP17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RANBP17 gene
    XPO72  
    2 SIMAP similar genes for RANBP17 using alignment to 9 protein entries:     RBP17_HUMAN (see all proteins):
    DKFZp666P032    XPO7

    RANBP17 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RANBP17
    PGOHUM00000257134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8307 SNPs in RANBP17 are shown (see all 8307)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790828991,2
    C,F--170287040(+) TCCAAC/TGTGCT 1 -- us2k12Minor allele frequency- T:0.04NA 122
    rs1428214461,2
    --170287101(+) TGTAAA/GACCTA 1 -- us2k10--------
    rs1904658071,2
    --170287263(+) CTTCTA/GCATGG 1 -- us2k10--------
    rs591282241,2
    C--170287330(+) AAAAA-/AA/AAA
            
    GAAAG
    2 -- us2k1 cds11NA 2
    rs1827475141,2
    --170287378(+) GGAAGA/GCTCAG 1 -- us2k10--------
    rs1870333691,2
    --170287499(+) TGGGAC/GAGGAG 1 -- us2k10--------
    rs733118591,2
    C,F--170287518(+) ATGAAA/CATTTC 1 -- us2k12Minor allele frequency- C:0.03WA 120
    rs1928619501,2
    --170287523(+) AATTTC/TAACTT 1 -- us2k10--------
    rs1844204471,2
    --170287564(+) TATAAC/TTAAAA 1 -- us2k10--------
    rs1878169641,2
    --170287587(+) TAGAGA/GGGATG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RANBP17 (170288874 - 170538874 bp, first 250kb of RANBP17)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for RANBP17 (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731088CNV Deletion23290073
    esv1782186CNV Deletion17803354
    esv2731087CNV Deletion23290073
    esv1010423CNV Deletion20482838
    esv2731086CNV Deletion23290073
    esv270865CNV Insertion20981092
    nsv507308CNV Insertion20534489
    nsv5130CNV Insertion18451855
    nsv508386CNV Loss20534489
    nsv5131CNV Loss18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606141    OMIM disorders: --

    2 diseases for RANBP17:    About MalaCards
    lymphoblastic leukemia    leukemia


    RANBP17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RANBP17
    Human Genome Epidemiology (HuGE) Navigator: RANBP17 (3 documents)

    Export disorders for RANBP17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RANBP17 gene, integrated from 9 sources (see all 11):
    (articles sorted by number of sources associating them with RANBP17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PubMed id 11024021)1, 2, 3 Kutay U.... Bischoff F.R. (2000)
    2. Identification of a novel putative Ran-binding protein and its close homologue. (PubMed id 11071879)1, 2, 9 Koch P.... Janssen J.W.G. (2000)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. Identification of RANBP16 and RANBP17 as novel intera ction partners for the bHLH transcription factor E12. (PubMed id 20503194)1 Lee J.H....Smas C.M. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64901 HGNC: 14428 AceView: RANBP17 Ensembl:ENSG00000204764 euGenes: HUgn64901
    ECgene: RANBP17 H-InvDB: RANBP17

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    NameDescription
    PharmGKB entry for RANBP17 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RANBP17 Genetics and Cytogenetics in Oncology and Haematology

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