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Aliases for RANBP17 Gene

Aliases for RANBP17 Gene

  • RAN Binding Protein 17 2 3 5

External Ids for RANBP17 Gene

Previous GeneCards Identifiers for RANBP17 Gene

  • GC05P170523
  • GC05P170991
  • GC05P170224
  • GC05P170270
  • GC05P170271
  • GC05P170237
  • GC05P170221
  • GC05P165386

Summaries for RANBP17 Gene

Entrez Gene Summary for RANBP17 Gene

  • The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002]

GeneCards Summary for RANBP17 Gene

RANBP17 (RAN Binding Protein 17) is a Protein Coding gene. GO annotations related to this gene include GTP binding and Ran GTPase binding. An important paralog of this gene is XPO7.

UniProtKB/Swiss-Prot for RANBP17 Gene

  • May function as a nuclear transport receptor.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP17 Gene

Genomics for RANBP17 Gene

Regulatory Elements for RANBP17 Gene

Enhancers for RANBP17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G170772 0.9 ENCODE dbSUPER 10 -88.6 -88563 1.8 ZBTB11 E2F5 TAL1 ELF1 ZIC2 ZNF83 FOSL1 TCF12 ARID1B ATF3 RANBP17 RN7SL623P ENSG00000253348 GABRP GC05P170775
GH05G170791 0.5 ENCODE 10.2 -70.3 -70339 0.2 CTCF ZNF654 RFX1 SMC3 RAD21 GABRP RANBP17 RN7SL623P ENSG00000253858 ENSG00000253348
GH05G170631 1.5 FANTOM5 Ensembl ENCODE 1.3 -229.0 -228955 3.4 INSM2 ZNF76 ZNF2 RAD21 GLIS2 EGR1 ZNF366 ZNF143 ZNF391 ZNF263 RANBP17 PIR52932 ENSG00000253858
GH05G170861 1.2 FANTOM5 ENCODE 0.7 +0.7 672 2.3 ZNF76 SIN3A YBX1 ZBTB7B RCOR1 EGR2 SP3 ZNF280D HCFC1 GATAD2B LOC100419059 RN7SL623P RANBP17
GH05G170951 0.3 FANTOM5 1.9 +89.7 89675 0.1 RANBP17 LOC100240749 GC05P171032
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RANBP17 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP17 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000190607 430 1401 SIN3A ZNF76 YBX1 RAD21 ZBTB7B RCOR1 EGR2 SP3 ZNF280D HCFC1

Genomic Location for RANBP17 Gene

Chromosome:
5
Start:
170,861,870 bp from pter
End:
171,300,450 bp from pter
Size:
438,581 bases
Orientation:
Plus strand

Genomic View for RANBP17 Gene

Genes around RANBP17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP17 Gene

Proteins for RANBP17 Gene

  • Protein details for RANBP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2T7-RBP17_HUMAN
    Recommended name:
    Ran-binding protein 17
    Protein Accession:
    Q9H2T7
    Secondary Accessions:
    • Q8IU74

    Protein attributes for RANBP17 Gene

    Size:
    1088 amino acids
    Molecular mass:
    124375 Da
    Quaternary structure:
    • Binds to nucleoporins and the GTP-bound form of Ran.
    SequenceCaution:
    • Sequence=BAB55427.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP17 Gene

Post-translational modifications for RANBP17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RANBP17 Gene

Domains & Families for RANBP17 Gene

Protein Domains for RANBP17 Gene

Suggested Antigen Peptide Sequences for RANBP17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2T7

UniProtKB/Swiss-Prot:

RBP17_HUMAN :
  • Belongs to the exportin family.
Family:
  • Belongs to the exportin family.
genes like me logo Genes that share domains with RANBP17: view

No data available for Gene Families for RANBP17 Gene

Function for RANBP17 Gene

Molecular function for RANBP17 Gene

UniProtKB/Swiss-Prot Function:
May function as a nuclear transport receptor.

Gene Ontology (GO) - Molecular Function for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005049 nuclear export signal receptor activity IBA --
GO:0005525 GTP binding NAS 11024021
GO:0008536 Ran GTPase binding IBA,IEA --
genes like me logo Genes that share ontologies with RANBP17: view

Phenotypes for RANBP17 Gene

genes like me logo Genes that share phenotypes with RANBP17: view

Animal Model Products

CRISPR Products

miRNA for RANBP17 Gene

miRTarBase miRNAs that target RANBP17

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP17 Gene

Localization for RANBP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP17 Gene

Cytoplasm. Nucleus. Nucleus, nuclear pore complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP17 gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005643 nuclear pore NAS 11024021
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with RANBP17: view

Pathways & Interactions for RANBP17 Gene

SuperPathways for RANBP17 Gene

No Data Available

SIGNOR curated interactions for RANBP17 Gene

Activates:

Gene Ontology (GO) - Biological Process for RANBP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus NAS 11024021
GO:0006611 protein export from nucleus IBA --
GO:0006810 transport IEA --
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RANBP17: view

No data available for Pathways by source for RANBP17 Gene

Drugs & Compounds for RANBP17 Gene

(1) Drugs for RANBP17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RANBP17: view

Transcripts for RANBP17 Gene

Unigene Clusters for RANBP17 Gene

RAN binding protein 17:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP17 Gene

No ASD Table

Relevant External Links for RANBP17 Gene

GeneLoc Exon Structure for
RANBP17
ECgene alternative splicing isoforms for
RANBP17

Expression for RANBP17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP17 Gene

mRNA differential expression in normal tissues according to GTEx for RANBP17 Gene

This gene is overexpressed in Testis (x5.1).

Protein differential expression in normal tissues from HIPED for RANBP17 Gene

This gene is overexpressed in Testis (41.2) and Brain (17.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP17 Gene



Protein tissue co-expression partners for RANBP17 Gene

NURSA nuclear receptor signaling pathways regulating expression of RANBP17 Gene:

RANBP17

SOURCE GeneReport for Unigene cluster for RANBP17 Gene:

Hs.410810

mRNA Expression by UniProt/SwissProt for RANBP17 Gene:

Q9H2T7-RBP17_HUMAN
Tissue specificity: Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.

Evidence on tissue expression from TISSUES for RANBP17 Gene

  • Thyroid gland(4.2)
genes like me logo Genes that share expression patterns with RANBP17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP17 Gene

Orthologs for RANBP17 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP17 34 35
  • 99.63 (n)
dog
(Canis familiaris)
Mammalia RANBP17 34 35
  • 94.39 (n)
cow
(Bos Taurus)
Mammalia RANBP17 34 35
  • 93.85 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp17 34
  • 90.2 (n)
mouse
(Mus musculus)
Mammalia Ranbp17 34 16 35
  • 89.98 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP17 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP17 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC769940 34
  • 76.94 (n)
RANBP17 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 84 (a)
OneToMany
-- 35
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Ranbp16 35
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35A5.8 36 35
  • 40 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.23305 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToMany
Species where no ortholog for RANBP17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • zebrafish (Danio rerio)

Evolution for RANBP17 Gene

ENSEMBL:
Gene Tree for RANBP17 (if available)
TreeFam:
Gene Tree for RANBP17 (if available)

Paralogs for RANBP17 Gene

Paralogs for RANBP17 Gene

(2) SIMAP similar genes for RANBP17 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for RANBP17 Gene

genes like me logo Genes that share paralogs with RANBP17: view

Variants for RANBP17 Gene

Sequence variations from dbSNP and Humsavar for RANBP17 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000002188 -- 171,020,376(+) AAAGT(A/C)TCCCA intron-variant
rs1000005393 -- 171,236,181(+) AACTG(C/T)TCCTT intron-variant
rs1000006793 -- 171,160,989(+) GAAGC(A/G)GGGTT intron-variant
rs1000011330 -- 171,292,243(+) ATTGG(A/C)AGATT intron-variant
rs1000012964 -- 171,111,018(+) CCCCC(A/C/G)ACCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP17 Gene

Variant ID Type Subtype PubMed ID
esv1010423 CNV deletion 20482838
esv1782186 CNV deletion 17803354
esv2731086 CNV deletion 23290073
esv2731087 CNV deletion 23290073
esv2731088 CNV deletion 23290073
esv2762567 CNV loss 21179565
esv3306589 CNV mobile element insertion 20981092
esv3410773 CNV insertion 20981092
esv3570550 CNV loss 25503493
esv3570551 CNV loss 25503493
esv3575897 CNV gain 25503493
esv3607572 CNV loss 21293372
esv3607573 CNV loss 21293372
esv3607574 CNV loss 21293372
esv3607575 CNV gain 21293372
esv3607576 CNV loss 21293372
esv3607577 CNV loss 21293372
esv6863 CNV gain 19470904
nsv1028839 CNV gain 25217958
nsv1074346 CNV deletion 25765185
nsv328840 CNV deletion 16902084
nsv507308 OTHER sequence alteration 20534489
nsv508386 CNV deletion 20534489
nsv5129 CNV deletion 18451855
nsv5130 CNV insertion 18451855
nsv5131 CNV deletion 18451855
nsv518091 CNV loss 19592680
nsv520782 CNV gain 19592680
nsv525376 CNV loss 19592680
nsv600262 CNV gain 21841781
nsv830550 CNV loss 17160897
nsv955881 CNV deletion 24416366
nsv969013 CNV duplication 23825009

Variation tolerance for RANBP17 Gene

Residual Variation Intolerance Score: 54.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.57; 65.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP17 Gene

Disorders for RANBP17 Gene

Relevant External Links for RANBP17

Genetic Association Database (GAD)
RANBP17
Human Genome Epidemiology (HuGE) Navigator
RANBP17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP17

No disorders were found for RANBP17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP17 Gene

Publications for RANBP17 Gene

  1. Identification of a novel putative Ran-binding protein and its close homologue. (PMID: 11071879) Koch P. … Janssen J.W.G. (Biochem. Biophys. Res. Commun. 2000) 3 4 22 64
  2. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. (PMID: 11024021) Kutay U. … Bischoff F.R. (J. Biol. Chem. 2000) 2 3 4 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3 64

Products for RANBP17 Gene

Sources for RANBP17 Gene

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