RANBP10 Gene
protein-coding GIFtS: 51
GCID: GC16M067757
|
|
RAN binding protein 10
| |
Aliases for RANBP10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| RAN Binding Protein 101 2 | | KIAA14641 3 | | Ran-Binding Protein 102 | | RanBP103 |
Export aliases for RANBP10 gene to outside databasesPrevious GC identifers: GC16M067533 GC16M066314 GC16M053629 |
Summaries for RANBP10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20Function: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential rolein hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (Bysimilarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhancesdihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activityof NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos anddoes not activate the Ras pathway
|
Genomic Views for RANBP10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RANBP10 gene promoter: Nkx3-1 AML1a Tal-1 MIF-1 E47 Egr-2 NRF-2 ATF RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for RANBP10
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANBP10 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22RANBP10 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M067757: view genomic region
(about GC identifiers)
Start:
|
67,757,005 bp from pter |
End:
|
67,840,555 bp from pter |
Size:
|
83,551 bases |
Orientation:
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minus strand |
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Proteins for RANBP10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20 (See
protein sequence)Recommended Name: Ran-binding protein 10 Size: 620 amino acids; 67257 Da
Subunit: May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR.Interacts with TUBB1. May interact with TUBB5 (By similarity)
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic
Sequence caution: Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4FTY2 Q9P264Explore the universe of human proteins at neXtProt for RANBP10: NX_Q6VN20
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6VN20 RANBP10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065901.1 ENSEMBL proteins: ENSP00000316589 ENSP00000392808 ENSP00000416460 ENSP00000442249 ENSP00000410617 Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RANBP10 for ontologies About GeneDecksing
RANBP10 Antibody Products: Assay Products for RANBP10: |
Protein
Domains / Families for RANBP10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RANBP10 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q6VN20ProtoNet protein and cluster: Q6VN20 2 Blocks protein families: IPB006594 Lissencephaly type-1-like homology motif IPB006595 CTLH
UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20Domain: The SPRY domain mediates the interaction with MET (By similarity)Similarity: Belongs to the RANBP9/10 familySimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 CTLH domainSimilarity: Contains 1 LisH domain |
Function for RANBP10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20Function: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential rolein hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (Bysimilarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhancesdihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activityof NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos anddoes not activate the Ras pathway
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RANBP10 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RANBP10 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RANBP10 (NM_020850) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RANBP10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANBP10  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP10 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005087 | Ran guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0008536 | Ran GTPase binding |
IEA | -- | | GO:0048487 | beta-tubulin binding |
IEA | -- |
RANBP10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RANBP10:
|
Pathways & Interactions for RANBP10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Development HGF signaling pathway | |
1 BioSystems Pathway for RANBP10 
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RANBP10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/40 Interacting proteins for RANBP10 (Q6VN203 ENSP000003165894) via UniProtKB, MINT, STRING, and/or I2D (see all 40)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000226 | microtubule cytoskeleton organization |
IEA | -- |
RANBP10 for ontologies About GeneDecksing
|
Drugs & Compounds for RANBP10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for RANBP10 Search CenterWatch for drugs/clinical trials and news about RANBP10 / RBP10 
|
Transcripts for RANBP10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for RANBP10 gene: NM_020850.1 Unigene Cluster for RANBP10: RAN binding protein 10 Hs.368569 [show with all ESTs]Unigene Representative Sequence: AY3373135 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000317506(uc002eud.3 uc010ceo.3 uc010vju.2 uc010vjv.2) ENST00000448631(uc010vjw.1) ENST00000411657 ENST00000536251 ENST00000425512(uc010vjx.1 uc010vjy.1)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RANBP10 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RANBP10 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RANBP10 (NM_020850) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RANBP10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANBP10  |
Additional cDNA sequence: AB040897.1 AK000686.1 AK055634.1 AK055727.1 AK295171.1 AK295530.1 AK298806.1 AK304030.1 AL137299.1 AY337313.1 BC099917.1 BC121176.1 BC121177.2 5 DOTS entries: DT.216147 DT.100035957 DT.100816963 DT.97843941 DT.120718318 24/165 AceView cDNA sequences (see all 165): BU681946 AK055727 BM757122 AY337313 CD364797 CK300853 AI342430 T35156 F12528 AI811872 NM_020850 AL137299 AI092780 AI200638 F10146 AA255464 AW593043 Z40304 AW027263 AK055634 CB853016 AA923451 AI335882 CA395964 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for RANBP10
|
Expression for RANBP10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RANBP10 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: --
About this image See RANBP10 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RANBP10
SOURCE GeneReport for Unigene cluster: Hs.368569 UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20Tissue specificity: Broadly expressed, with highest levels in skeletal muscle SABiosciences Custom PCR Arrays for RANBP10
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RANBP10 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RANBP10 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RANBP10 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RANBP10 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP10 |
Orthologs for RANBP10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RANBP10 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for RANBP10 (if available) TreeFam Gene Tree for RANBP10 (if available)  |
Paralogs for RANBP10 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for RANBP10 gene
- SPRYD32 RANBP92
1 SIMAP similar gene for RANBP10 using alignment to 5 protein entries: RBP10_HUMAN (see all proteins):RANBP9
RANBP10 for paralogs About GeneDecksing
|
Genomic Variants for RANBP10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 16 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for RANBP10 (67757005 - 67840555 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for RANBP10 1 CNV: 35392  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RANBP10 |
|
Disorders
/ Diseases for RANBP10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RANBP10 for disorders About GeneDecksing
OMIM gene information: 614031
OMIM disorders: --
1 disease for RANBP10: About MalaCardslissencephaly Export disorders for RANBP10 gene to outside databases
|
Publications for RANBP10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RANBP10 gene, integrated from 9 sources (see all 21): (articles sorted by number of sources associating them with RANBP10) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PubMed id 14684163)1, 2, 3 Wang D.... Wu G. (2004)
- RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. (PubMed id 18347012)1, 2 Schulze H....Shivdasani R.A. (2008)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
|
External Searches for RANBP10 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RANBP10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RANBP10 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RANBP10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for RANBP10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RANBP10 gene: Search GeneIP for patents involving RANBP10
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for RANBP10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP10 |
|  |  |  | | | ThermoFisher Antibodies for RANBP10 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RANBP10 |
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