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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RANBP10 Gene

protein-coding   GIFtS: 51
GCID: GC16M067757

RAN binding protein 10

 Explore 1 disease affiliated with
RANBP10 via our new
 Human Malady Compendium 
Biological research products
for RANBP10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
RAN Binding Protein 101 2
KIAA14641 3
Ran-Binding Protein 102
RanBP103

External Ids:    HGNC: 292851   Entrez Gene: 576102   Ensembl: ENSG000001410847   OMIM: 6140315   UniProtKB: Q6VN203   

Export aliases for RANBP10 gene to outside databases

Previous GC identifers: GC16M067533 GC16M066314 GC16M053629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20
Function: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role
in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By
similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances
dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity
of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and
does not activate the Ras pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RANBP10 gene promoter:
         Nkx3-1   AML1a   Tal-1   MIF-1   E47   Egr-2   NRF-2   ATF   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP10 promoter sequence
   Search SABiosciences Chromatin IP Primers for RANBP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RANBP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22

RANBP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP10 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M067757:  view genomic region     (about GC identifiers)

Start:
67,757,005 bp from pter      End:
67,840,555 bp from pter
Size:
83,551 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20 (See protein sequence)
Recommended Name: Ran-binding protein 10  
Size: 620 amino acids; 67257 Da
Subunit: May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR.
Interacts with TUBB1. May interact with TUBB5 (By similarity)
Subcellular location: Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic
Sequence caution: Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4FTY2 Q9P264

Explore the universe of human proteins at neXtProt for RANBP10: NX_Q6VN20

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6VN20

  • RANBP10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065901.1  
    ENSEMBL proteins: 
     ENSP00000316589   ENSP00000392808   ENSP00000416460   ENSP00000442249   ENSP00000410617  

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    Uscn Proteins for RANBP10

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IEA--
    GO:0005881cytoplasmic microtubule IEA--


    RANBP10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RANBP10 for domains           About GeneDecksing

    5/9 InterPro domains/families (see all 9):
     IPR001870 B30.2/SPRY
     IPR006594 LisH_dimerisation
     IPR013144 CRA_dom
     IPR024964 CTLH/CRA
     IPR013720 LisH_dimerisation_subgr

    Graphical View of Domain Structure for InterPro Entry Q6VN20

    ProtoNet protein and cluster: Q6VN20

    2 Blocks protein families:
    IPB006594 Lissencephaly type-1-like homology motif
    IPB006595 CTLH


    UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20
    Domain: The SPRY domain mediates the interaction with MET (By similarity)
    Similarity: Belongs to the RANBP9/10 family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 CTLH domain
    Similarity: Contains 1 LisH domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20
    Function: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role
    in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By
    similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances
    dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity
    of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and
    does not activate the Ras pathway

    miRNA
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    hsa-miR-3152-3p hsa-miR-3194-5p hsa-miR-30d hsa-miR-3916 hsa-miR-4267 hsa-miR-890 hsa-miR-30a hsa-miR-4293
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005087Ran guanyl-nucleotide exchange factor activity IEA--
    GO:0008536Ran GTPase binding IEA--
    GO:0048487beta-tubulin binding IEA--


    RANBP10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RANBP10:
     Decreased Wnt reporter activit 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Development HGF signaling pathway
    Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)0.23


    1 BioSystems Pathway for RANBP10 
        Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RANBP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/40 Interacting proteins for RANBP10 (Q6VN203 ENSP000003165894) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CACHD1Q5VU973, ENSP000002900394I2D: score=3 STRING: ENSP00000290039
    METP085813, ENSP000003172724I2D: score=2 STRING: ENSP00000317272
    RANP628263, ENSP000003961274I2D: score=2 STRING: ENSP00000396127
    CNTNAP4Q9C0A03, ENSP000004176284I2D: score=2 STRING: ENSP00000417628
    IGSF1Q8N6C53, ENSP000003550104I2D: score=3 STRING: ENSP00000355010
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--


    RANBP10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RANBP10
    Search CenterWatch for drugs/clinical trials and news about RANBP10 / RBP10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for RANBP10 gene: 
    NM_020850.1  

    Unigene Cluster for RANBP10:

    RAN binding protein 10
    Hs.368569  [show with all ESTs]
    Unigene Representative Sequence: AY337313
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317506(uc002eud.3 uc010ceo.3 uc010vju.2 uc010vjv.2)
    ENST00000448631(uc010vjw.1) ENST00000411657 ENST00000536251 ENST00000425512(uc010vjx.1 uc010vjy.1)


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    hsa-miR-3152-3p hsa-miR-3194-5p hsa-miR-30d hsa-miR-3916 hsa-miR-4267 hsa-miR-890 hsa-miR-30a hsa-miR-4293
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    Additional cDNA sequence: 

    AB040897.1 AK000686.1 AK055634.1 AK055727.1 AK295171.1 AK295530.1 AK298806.1 AK304030.1 
    AL137299.1 AY337313.1 BC099917.1 BC121176.1 BC121177.2 

    5 DOTS entries:

    DT.216147  DT.100035957  DT.100816963  DT.97843941  DT.120718318 

    24/165 AceView cDNA sequences (see all 165):

    BU681946 AK055727 BM757122 AY337313 CD364797 CK300853 AI342430 T35156 
    F12528 AI811872 NM_020850 AL137299 AI092780 AI200638 F10146 AA255464 
    AW593043 Z40304 AW027263 AK055634 CB853016 AA923451 AI335882 CA395964 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                  
    SP2:                    -     -                                                                                       
    SP3:                                                                                                                  
    SP4:                                                  -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for RANBP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RANBP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RANBP10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RANBP10

    SOURCE GeneReport for Unigene cluster: Hs.368569

    UniProtKB/Swiss-Prot: RBP10_HUMAN, Q6VN20
    Tissue specificity: Broadly expressed, with highest levels in skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RANBP10 gene from 4/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RANBP101 RAN binding protein 10 79.87(n)
    88.45(a)
      415653  XM_414019.3  XP_414019.3 
    lizard
    (Anolis carolinensis)
    Reptilia RANBP106
    --
    85(a)
    1 ↔ 1
    GL343295.1(711877-753706)
    zebrafish
    (Danio rerio)
    Actinopterygii ranbp101 RAN binding protein 10 75.86(n)
    82.88(a)
      793293  NM_001045050.1  NP_001038515.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RanBPM6
    Ran-binding protein M
    28(a)
    1 → many
    2R(6317217-6324086)


    ENSEMBL Gene Tree for RANBP10 (if available)
    TreeFam Gene Tree for RANBP10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RANBP10 gene
    SPRYD32  RANBP92  
    1 SIMAP similar gene for RANBP10 using alignment to 5 protein entries:     RBP10_HUMAN (see all proteins):
    RANBP9

    RANBP10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1101 NCBI SNPs in RANBP10 are shown (see all 1101    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1837642101,2
    --67756557(+) GAATAG/TCTGGG 1 -- ds50010--------
    rs1399653211,2
    --67756772(+) AAGCCA/GTTTCA 1 -- ds50010--------
    rs1115317741,2
    C,--67756855(+) AAGGCA/CCCTGA 1 -- ds50013Minor allele frequency- C:0.05CSA WA 121
    rs1153672201,2
    F,--67756927(+) AAGGGG/ATGCCA 1 -- ds50011Minor allele frequency- A:0.02WA 118
    rs665864551,2
    C,--67756941(+) TCAGT-/AAGACT 1 -- ds50010--------
    rs1453542011,2
    --67757034(+) TTTTTG/TGTCTC 1 -- ut310--------
    rs124452801,2
    C,F,H--67757036(+) TTTTGT/GCTCTC 1 -- ut31 ese36Minor allele frequency- G:0.01NS EA NA 684
    rs12451,2
    C,H--67757160(+) GTGCAC/GAATGT 1 -- ut315Minor allele frequency- G:0.00MN NS EA 602
    rs1880655811,2
    --67757411(+) GAAGGC/TGCTAG 1 -- ut310--------
    rs1813063981,2
    --67757425(+) GCCAGA/GCAGTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for RANBP10 (67757005 - 67840555 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RANBP10
         1 CNV: 35392

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for RANBP10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RANBP10 for disorders           About GeneDecksing

    OMIM gene information: 614031    OMIM disorders: --

    1 disease for RANBP10:    About MalaCards
    lissencephaly


    Export disorders for RANBP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RANBP10 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with RANBP10)
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    world of online information

    1. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PubMed id 14684163)1, 2, 3 Wang D.... Wu G. (2004)
    2. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. (PubMed id 18347012)1, 2 Schulze H....Shivdasani R.A. (2008)
    3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)1, 2 Nagase T.... Ohara O. (2000)
    4. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. NOTCH1 nuclear interactome reveals key regulators of i ts transcriptional activity and oncogenic function. (PubMed id 23022380)1 Yatim A....Benkirane M. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57610 HGNC: 29285 AceView: RANBP10 Ensembl:ENSG00000141084 euGenes: HUgn57610
    ECgene: RANBP10 H-InvDB: RANBP10

    (According to HUGE)
    About This Section
    HUGE: KIAA1464

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RANBP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RANBP10 gene:
    Search GeneIP for patents involving RANBP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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