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Aliases for RANBP10 Gene

Aliases for RANBP10 Gene

  • RAN Binding Protein 10 2 3
  • KIAA1464 4 6
  • RanBP10 4

External Ids for RANBP10 Gene

Summaries for RANBP10 Gene

GeneCards Summary for RANBP10 Gene

RANBP10 (RAN Binding Protein 10) is a Protein Coding gene. Among its related pathways are Development HGF signaling pathway. GO annotations related to this gene include beta-tubulin binding and Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RANBP9.

UniProtKB/Swiss-Prot for RANBP10 Gene

  • Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP10 Gene

Genomics for RANBP10 Gene

Genomic Location for RANBP10 Gene

Start:
67,723,066 bp from pter
End:
67,806,652 bp from pter
Size:
83,587 bases
Orientation:
Minus strand

Genomic View for RANBP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP10 Gene

Regulatory Elements for RANBP10 Gene

Proteins for RANBP10 Gene

  • Protein details for RANBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VN20-RBP10_HUMAN
    Recommended name:
    Ran-binding protein 10
    Protein Accession:
    Q6VN20
    Secondary Accessions:
    • A4FTY2
    • B4DID0
    • B4DQH9
    • E7EW27
    • Q9P264

    Protein attributes for RANBP10 Gene

    Size:
    620 amino acids
    Molecular mass:
    67257 Da
    Quaternary structure:
    • May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 (By similarity).
    SequenceCaution:
    • Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP10 Gene

Proteomics data for RANBP10 Gene at MOPED

Post-translational modifications for RANBP10 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys293 and Lys333

Other Protein References for RANBP10 Gene

No data available for DME Specific Peptides for RANBP10 Gene

Domains for RANBP10 Gene

UniProtKB/Swiss-Prot:

RBP10_HUMAN
Domain:
  • The SPRY domain mediates the interaction with MET.:
    • Q6VN20
  • Contains 1 B30.2/SPRY domain.:
    • Q6VN20
  • Contains 1 CTLH domain.:
    • Q6VN20
  • Contains 1 LisH domain.:
    • Q6VN20
Family:
  • Belongs to the RANBP9/10 family.:
    • Q6VN20
genes like me logo Genes that share domains with RANBP10: view

No data available for Gene Families for RANBP10 Gene

Function for RANBP10 Gene

Molecular function for RANBP10 Gene

UniProtKB/Swiss-Prot Function: Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.

Gene Ontology (GO) - Molecular Function for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005087 Ran guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0008536 Ran GTPase binding IEA --
GO:0048487 beta-tubulin binding IEA --
genes like me logo Genes that share ontologies with RANBP10: view

Phenotypes for RANBP10 Gene

genes like me logo Genes that share phenotypes with RANBP10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RANBP10 Gene

Localization for RANBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP10 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP10 Gene COMPARTMENTS Subcellular localization image for RANBP10 gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol IEA --
GO:0005881 cytoplasmic microtubule IEA --
genes like me logo Genes that share ontologies with RANBP10: view

Pathways for RANBP10 Gene

genes like me logo Genes that share pathways with RANBP10: view

Pathways by source for RANBP10 Gene

Gene Ontology (GO) - Biological Process for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RANBP10: view

Transcripts for RANBP10 Gene

Unigene Clusters for RANBP10 Gene

RAN binding protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for RANBP10 Gene

GeneLoc Exon Structure for
RANBP10
ECgene alternative splicing isoforms for
RANBP10

Expression for RANBP10 Gene

mRNA expression in normal human tissues for RANBP10 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP10 Gene

SOURCE GeneReport for Unigene cluster for RANBP10 Gene Hs.368569

mRNA Expression by UniProt/SwissProt for RANBP10 Gene

Q6VN20-RBP10_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle.
genes like me logo Genes that share expressions with RANBP10: view

Orthologs for RANBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP10 36
  • 99.68 (n)
  • 99.84 (a)
RANBP10 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP10 36
  • 93.49 (n)
  • 98.06 (a)
RANBP10 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP10 36
  • 93.6 (n)
  • 97.9 (a)
RANBP10 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp10 36
  • 91.72 (n)
  • 97.74 (a)
Ranbp10 16
Ranbp10 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP10 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP10 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp10 36
  • 91.99 (n)
  • 97.42 (a)
chicken
(Gallus gallus)
Aves RANBP10 36
  • 80.46 (n)
  • 90.09 (a)
RANBP10 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP10 37
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ranbp10 36
  • 75.91 (n)
  • 82.88 (a)
ranbp10 37
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RanBPM 37
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.7 37
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 37
  • 13 (a)
OneToMany
VID30 39
Species with no ortholog for RANBP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP10 Gene

ENSEMBL:
Gene Tree for RANBP10 (if available)
TreeFam:
Gene Tree for RANBP10 (if available)

Paralogs for RANBP10 Gene

Paralogs for RANBP10 Gene

Selected SIMAP similar genes for RANBP10 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RANBP10: view

Variants for RANBP10 Gene

Sequence variations from dbSNP and Humsavar for RANBP10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1245 -- 67,723,257(+) GTGCA(C/G)AATGT utr-variant-3-prime
rs919365 -- 67,759,233(-) GACCC(C/T)TGGCA intron-variant
rs1057553 -- 67,726,359(-) TCCAT(A/G)GGCAA utr-variant-3-prime
rs2115391 -- 67,759,448(-) GGGAA(A/G)AAACC intron-variant
rs2115392 -- 67,730,632(-) CCCCA(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP10 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv1842 CNV Insertion 18451855
esv2662518 CNV Deletion 23128226

Relevant External Links for RANBP10 Gene

HapMap Linkage Disequilibrium report
RANBP10

Disorders for RANBP10 Gene

No disorders were found for RANBP10 Gene.

No data available for UniProtKB/Swiss-Prot for RANBP10 Gene

Publications for RANBP10 Gene

  1. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PMID: 14684163) Wang D. … Wu G. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10819331) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. (PMID: 18347012) Schulze H. … Shivdasani R.A. (J. Biol. Chem. 2008) 3 4
  5. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PMID: 19953087) Persaud A. … Rotin D. (Mol. Syst. Biol. 2009) 3

Products for RANBP10 Gene

Sources for RANBP10 Gene

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