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Aliases for RANBP10 Gene

Aliases for RANBP10 Gene

  • RAN Binding Protein 10 2 3 5
  • KIAA1464 4
  • RanBP10 4

External Ids for RANBP10 Gene

Previous GeneCards Identifiers for RANBP10 Gene

  • GC16M067533
  • GC16M066314
  • GC16M053629

Summaries for RANBP10 Gene

Entrez Gene Summary for RANBP10 Gene

  • RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

GeneCards Summary for RANBP10 Gene

RANBP10 (RAN Binding Protein 10) is a Protein Coding gene. Among its related pathways are Development HGF signaling pathway. GO annotations related to this gene include beta-tubulin binding and Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RANBP9.

UniProtKB/Swiss-Prot for RANBP10 Gene

  • Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP10 Gene

Genomics for RANBP10 Gene

Regulatory Elements for RANBP10 Gene

Promoters for RANBP10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANBP10 on UCSC Golden Path with GeneCards custom track

Genomic Location for RANBP10 Gene

Chromosome:
16
Start:
67,723,066 bp from pter
End:
67,806,652 bp from pter
Size:
83,587 bases
Orientation:
Minus strand

Genomic View for RANBP10 Gene

Genes around RANBP10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP10 Gene

Proteins for RANBP10 Gene

  • Protein details for RANBP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VN20-RBP10_HUMAN
    Recommended name:
    Ran-binding protein 10
    Protein Accession:
    Q6VN20
    Secondary Accessions:
    • A4FTY2
    • B4DID0
    • B4DQH9
    • E7EW27
    • Q9P264

    Protein attributes for RANBP10 Gene

    Size:
    620 amino acids
    Molecular mass:
    67257 Da
    Quaternary structure:
    • May form homodimers. Interacts with RAN and RANBP9. Interacts with the HGF receptor MET. Interacts with AR. Interacts with TUBB1. May interact with TUBB5 (By similarity).
    SequenceCaution:
    • Sequence=BAA95988.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RANBP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP10 Gene

Proteomics data for RANBP10 Gene at MOPED

Post-translational modifications for RANBP10 Gene

  • Ubiquitination at Lys 293 and Lys 333
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANBP10 Gene

Domains & Families for RANBP10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6VN20

UniProtKB/Swiss-Prot:

RBP10_HUMAN :
  • The SPRY domain mediates the interaction with MET.
  • Belongs to the RANBP9/10 family.
Domain:
  • The SPRY domain mediates the interaction with MET.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 CTLH domain.
  • Contains 1 LisH domain.
Family:
  • Belongs to the RANBP9/10 family.
genes like me logo Genes that share domains with RANBP10: view

No data available for Gene Families for RANBP10 Gene

Function for RANBP10 Gene

Molecular function for RANBP10 Gene

UniProtKB/Swiss-Prot Function:
Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.
genes like me logo Genes that share phenotypes with RANBP10: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RANBP10 Gene

Localization for RANBP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RANBP10 Gene

Cytoplasm, cytosol. Nucleus. Note=Predominantly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP10 Gene COMPARTMENTS Subcellular localization image for RANBP10 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RANBP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RANBP10: view

Pathways & Interactions for RANBP10 Gene

genes like me logo Genes that share pathways with RANBP10: view

Pathways by source for RANBP10 Gene

Gene Ontology (GO) - Biological Process for RANBP10 Gene

None

No data available for SIGNOR curated interactions for RANBP10 Gene

Drugs & Compounds for RANBP10 Gene

No Compound Related Data Available

Transcripts for RANBP10 Gene

Unigene Clusters for RANBP10 Gene

RAN binding protein 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for RANBP10 Gene

GeneLoc Exon Structure for
RANBP10
ECgene alternative splicing isoforms for
RANBP10

Expression for RANBP10 Gene

mRNA expression in normal human tissues for RANBP10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RANBP10 Gene

This gene is overexpressed in Liver (8.9) and Pancreas (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP10 Gene



SOURCE GeneReport for Unigene cluster for RANBP10 Gene Hs.368569

mRNA Expression by UniProt/SwissProt for RANBP10 Gene

Q6VN20-RBP10_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle.
genes like me logo Genes that share expression patterns with RANBP10: view

Protein tissue co-expression partners for RANBP10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RANBP10 Gene

Orthologs for RANBP10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RANBP10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RANBP10 35
  • 93.49 (n)
  • 98.06 (a)
RANBP10 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP10 35
  • 93.6 (n)
  • 97.9 (a)
RANBP10 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp10 35
  • 91.72 (n)
  • 97.74 (a)
Ranbp10 16
Ranbp10 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RANBP10 35
  • 99.68 (n)
  • 99.84 (a)
RANBP10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp10 35
  • 91.99 (n)
  • 97.42 (a)
oppossum
(Monodelphis domestica)
Mammalia RANBP10 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP10 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP10 35
  • 80.46 (n)
  • 90.09 (a)
RANBP10 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP10 36
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ranbp10 35
  • 75.91 (n)
  • 82.88 (a)
ranbp10 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RanBPM 36
  • 28 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y54E5A.7 36
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VID30 36
  • 13 (a)
OneToMany
VID30 38
Species with no ortholog for RANBP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RANBP10 Gene

ENSEMBL:
Gene Tree for RANBP10 (if available)
TreeFam:
Gene Tree for RANBP10 (if available)

Paralogs for RANBP10 Gene

Paralogs for RANBP10 Gene

(1) SIMAP similar genes for RANBP10 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with RANBP10: view

Variants for RANBP10 Gene

Sequence variations from dbSNP and Humsavar for RANBP10 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1245 -- 67,723,257(+) GTGCA(C/G)AATGT utr-variant-3-prime
rs919365 -- 67,759,233(-) GACCC(C/T)TGGCA intron-variant
rs1057553 -- 67,726,359(-) TCCAT(A/G)GGCAA utr-variant-3-prime
rs2115391 -- 67,759,448(-) GGGAA(A/G)AAACC intron-variant
rs2115392 -- 67,730,632(-) CCCCA(C/T)GGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP10 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv1842 CNV Insertion 18451855
esv2662518 CNV Deletion 23128226

Variation tolerance for RANBP10 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP10 Gene

HapMap Linkage Disequilibrium report
RANBP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP10 Gene

Disorders for RANBP10 Gene

Relevant External Links for RANBP10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP10

No disorders were found for RANBP10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP10 Gene

Publications for RANBP10 Gene

  1. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling. (PMID: 14684163) Wang D. … Wu G. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  5. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PMID: 23667531) Cox J.L. … Rizzino A. (PLoS ONE 2013) 3

Products for RANBP10 Gene

Sources for RANBP10 Gene

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