External Ids for RANBP10 Gene
Previous GeneCards Identifiers for RANBP10 Gene
RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
GeneCards Summary for RANBP10 Gene
RANBP10 (RAN Binding Protein 10) is a Protein Coding gene. Among its related pathways are Development HGF signaling pathway and Signaling by GPCR. GO annotations related to this gene include beta-tubulin binding and Ran guanyl-nucleotide exchange factor activity. An important paralog of this gene is RANBP9.
UniProtKB/Swiss-Prot for RANBP10 Gene
Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway.