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Aliases for RANBP1 Gene

Aliases for RANBP1 Gene

  • RAN Binding Protein 1 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 221n 3
  • Ran-Specific GTPase-Activating Protein 3
  • HpaII Tiny Fragments Locus 9A 3
  • Ran-Binding Protein 1 4
  • RanBP1 4
  • HTF9A 3

External Ids for RANBP1 Gene

Previous GeneCards Identifiers for RANBP1 Gene

  • GC22P017045
  • GC22P018478
  • GC22P018479
  • GC22P003725

Summaries for RANBP1 Gene

Entrez Gene Summary for RANBP1 Gene

  • This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANBP1 Gene

RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Among its related pathways are HTLV-I infection and HIV Life Cycle. GO annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for RANBP1 Gene

  • Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Gene Wiki entry for RANBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP1 Gene

Genomics for RANBP1 Gene

Regulatory Elements for RANBP1 Gene

Enhancers for RANBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22F020078 1.1 FANTOM5 ENCODE 12.8 -34.4 -34417 5.2 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 DGCR8 RPL8P5 TRMT2A THAP7-AS1 THAP7 RPL7AP70 SCARF2 LINC01311 ENSG00000243762 RANBP1
GH22F020076 0.6 ENCODE 12.8 -39.0 -39030 1.1 HDGF PKNOX1 ARNT TBL1XR1 YBX1 GATA2 SMARCA5 ZBTB2 CEBPB ZEB2 ENSG00000243762 RANBP1 TRMT2A MIR185 ZDHHC8 CCDC188 DGCR8 MIR1306 MIR3618 ENSG00000277950
GH22F020025 1 ENCODE 12.6 -90.4 -90386 0.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 SIN3A YBX1 GATA2 KLF13 CEBPZ LINC01311 RANBP1 SCARF2 TBX1 THAP7-AS1 THAP7 GC22P020027 GC22P020033 GC22P020036
GH22F020020 1.1 ENCODE 12.6 -94.0 -93953 3.3 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A ZNF143 ZNF207 FOS LINC01311 THAP7 THAP7-AS1 LOC100420177 RANBP1 TRMT2A TBX1 ABHD17AP4 DGCR8 ARVCF
GH22F020114 0.4 ENCODE 0.8 +1.3 1308 4.6 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 RPL7AP70 TBX1 TUBA3GP ENSG00000273300 ENSG00000235578 LOC105372938 LOC100129254 SCARF2 ZDHHC8 RPL8P5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RANBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000672898 1562 2201 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1

Genomic Location for RANBP1 Gene

Chromosome:
22
Start:
20,115,938 bp from pter
End:
20,127,357 bp from pter
Size:
11,420 bases
Orientation:
Plus strand

Genomic View for RANBP1 Gene

Genes around RANBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP1 Gene

Proteins for RANBP1 Gene

  • Protein details for RANBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43487-RANG_HUMAN
    Recommended name:
    Ran-specific GTPase-activating protein
    Protein Accession:
    P43487
    Secondary Accessions:
    • Q53EY3

    Protein attributes for RANBP1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23310 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RANBP1 Gene

    Alternative splice isoforms for RANBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP1 Gene

Post-translational modifications for RANBP1 Gene

  • Ubiquitination at Lys 76 and Lys 134
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RANBP1 (RANBP1)

No data available for DME Specific Peptides for RANBP1 Gene

Domains & Families for RANBP1 Gene

Protein Domains for RANBP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P43487

UniProtKB/Swiss-Prot:

RANG_HUMAN :
  • Contains 1 RanBD1 domain.
  • Belongs to the RANBP1 family.
Domain:
  • Contains 1 RanBD1 domain.
Family:
  • Belongs to the RANBP1 family.
genes like me logo Genes that share domains with RANBP1: view

No data available for Gene Families for RANBP1 Gene

Function for RANBP1 Gene

Molecular function for RANBP1 Gene

GENATLAS Biochemistry:
Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome condensation (CHC1L) in association with Ran/TC4
UniProtKB/Swiss-Prot Function:
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Gene Ontology (GO) - Molecular Function for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity IMP,TAS 7616957
GO:0005096 contributes_to GTPase activator activity IEA,IBA --
GO:0005515 protein binding IPI 7616957
GO:0008536 Ran GTPase binding TAS 7882974
GO:0098641 cadherin binding involved in cell-cell adhesion IDA 25468996
genes like me logo Genes that share ontologies with RANBP1: view
genes like me logo Genes that share phenotypes with RANBP1: view

Animal Models for RANBP1 Gene

MGI Knock Outs for RANBP1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RANBP1 Gene

Localization for RANBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP1 Gene COMPARTMENTS Subcellular localization image for RANBP1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,TAS 16130169
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005813 centrosome IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP1 Gene

Pathways & Interactions for RANBP1 Gene

genes like me logo Genes that share pathways with RANBP1: view

Pathways by source for RANBP1 Gene

1 Cell Signaling Technology pathway for RANBP1 Gene
1 BioSystems pathway for RANBP1 Gene
2 KEGG pathways for RANBP1 Gene
2 Qiagen pathways for RANBP1 Gene

Gene Ontology (GO) - Biological Process for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA --
GO:0006405 RNA export from nucleus IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0006606 protein import into nucleus IBA --
GO:0007051 spindle organization IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for SIGNOR curated interactions for RANBP1 Gene

Drugs & Compounds for RANBP1 Gene

(2) Drugs for RANBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RANBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP1: view

Transcripts for RANBP1 Gene

Unigene Clusters for RANBP1 Gene

RAN binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP1 Gene

No ASD Table

Relevant External Links for RANBP1 Gene

GeneLoc Exon Structure for
RANBP1
ECgene alternative splicing isoforms for
RANBP1

Expression for RANBP1 Gene

mRNA expression in normal human tissues for RANBP1 Gene

Protein differential expression in normal tissues from HIPED for RANBP1 Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP1 Gene



Protein tissue co-expression partners for RANBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RANBP1 Gene:

RANBP1

SOURCE GeneReport for Unigene cluster for RANBP1 Gene:

Hs.24763
genes like me logo Genes that share expression patterns with RANBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RANBP1 Gene

Orthologs for RANBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP1 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia RANBP1 34 35
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Ranbp1 34 16 35
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp1 34
  • 88.5 (n)
cow
(Bos Taurus)
Mammalia RANBP1 34 35
  • 86.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP1 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP1 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP1 34 35
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia RANBP1 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp1 34
  • 73.91 (n)
MGC76028 34
zebrafish
(Danio rerio)
Actinopterygii ranbp1 34 35
  • 72.93 (n)
Dr.12411 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8810 34
fruit fly
(Drosophila melanogaster)
Insecta Nup358 35
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-9 35
  • 1 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER002W 34
  • 59.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17227g 34
  • 56.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB1 34 35
  • 55.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SIRANBP 34
  • 53.98 (n)
rice
(Oryza sativa)
Liliopsida Os03g0292800 34
  • 58.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00443 34
  • 61.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sbp1 34
  • 59.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9803 35
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1880 34
Species where no ortholog for RANBP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP1 Gene

ENSEMBL:
Gene Tree for RANBP1 (if available)
TreeFam:
Gene Tree for RANBP1 (if available)

Paralogs for RANBP1 Gene

genes like me logo Genes that share paralogs with RANBP1: view

No data available for Paralogs for RANBP1 Gene

Variants for RANBP1 Gene

Sequence variations from dbSNP and Humsavar for RANBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036567 A breast cancer sample
rs100798 -- 20,124,206(+) AGGTT(G/T)TGGGT intron-variant
rs111311060 -- 20,125,345(+) GGTAG(C/T)GACCG reference, synonymous-codon
rs111521918 -- 20,120,198(+) CCTAT(C/T)CAAGG intron-variant
rs111522241 -- 20,121,213(+) CTCCC(A/G)AAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP1 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2110469 CNV deletion 18987734
esv2758825 CNV loss 17122850
esv3557940 CNV deletion 23714750
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv1118943 CNV deletion 24896259
nsv1131651 CNV deletion 24896259
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for RANBP1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP1 Gene

Disorders for RANBP1 Gene

Relevant External Links for RANBP1

Genetic Association Database (GAD)
RANBP1
Human Genome Epidemiology (HuGE) Navigator
RANBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP1

No disorders were found for RANBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP1 Gene

Publications for RANBP1 Gene

  1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PMID: 7616957) Hayashi N. … Nishimoto T. (Mol. Gen. Genet. 1995) 2 3 4 22 64
  2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PMID: 10330396) Kehlenbach R.H. … Gerace L. (J. Cell Biol. 1999) 2 3 22 64
  3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran- GTP binding protein RanBP1. (PMID: 7882974) Bischoff F.R. … Ponstingl H. (EMBO J. 1995) 3 4 22 64
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  5. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. (PMID: 19270727) Rensen W.M. … Lavia P. (Oncogene 2009) 3 22 64

Products for RANBP1 Gene

Sources for RANBP1 Gene

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