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Aliases for RANBP1 Gene

Aliases for RANBP1 Gene

  • RAN Binding Protein 1 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 221n 3
  • HpaII Tiny Fragments Locus 9A 3
  • Ran-Binding Protein 1 4
  • RanBP1 4
  • HTF9A 3

External Ids for RANBP1 Gene

Previous GeneCards Identifiers for RANBP1 Gene

  • GC22P017045
  • GC22P018478
  • GC22P018479
  • GC22P003725

Summaries for RANBP1 Gene

Entrez Gene Summary for RANBP1 Gene

  • This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANBP1 Gene

RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Among its related pathways are HTLV-I infection and Infectious disease. GO annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity. An important paralog of this gene is RGPD8.

UniProtKB/Swiss-Prot for RANBP1 Gene

  • Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Gene Wiki entry for RANBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP1 Gene

Genomics for RANBP1 Gene

Regulatory Elements for RANBP1 Gene

Enhancers for RANBP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RANBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RANBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RANBP1 Gene

Chromosome:
22
Start:
20,115,938 bp from pter
End:
20,127,357 bp from pter
Size:
11,420 bases
Orientation:
Plus strand

Genomic View for RANBP1 Gene

Genes around RANBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP1 Gene

Proteins for RANBP1 Gene

  • Protein details for RANBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43487-RANG_HUMAN
    Recommended name:
    Ran-specific GTPase-activating protein
    Protein Accession:
    P43487
    Secondary Accessions:
    • Q53EY3

    Protein attributes for RANBP1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23310 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RANBP1 Gene

    Alternative splice isoforms for RANBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP1 Gene

Proteomics data for RANBP1 Gene at MOPED

Post-translational modifications for RANBP1 Gene

  • Ubiquitination at Lys 76 and Lys 134
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RANBP1 Gene

Domains & Families for RANBP1 Gene

Protein Domains for RANBP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P43487

UniProtKB/Swiss-Prot:

RANG_HUMAN :
  • Contains 1 RanBD1 domain.
  • Belongs to the RANBP1 family.
Domain:
  • Contains 1 RanBD1 domain.
Family:
  • Belongs to the RANBP1 family.
genes like me logo Genes that share domains with RANBP1: view

No data available for Gene Families for RANBP1 Gene

Function for RANBP1 Gene

Molecular function for RANBP1 Gene

GENATLAS Biochemistry:
Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome condensation (CHC1L) in association with Ran/TC4
UniProtKB/Swiss-Prot Function:
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
genes like me logo Genes that share phenotypes with RANBP1: view

Animal Models for RANBP1 Gene

MGI Knock Outs for RANBP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RANBP1 Gene

Localization for RANBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP1 Gene COMPARTMENTS Subcellular localization image for RANBP1 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 16130169
GO:0005737 cytoplasm IEA,TAS 16130169
genes like me logo Genes that share ontologies with RANBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP1 Gene

Pathways & Interactions for RANBP1 Gene

genes like me logo Genes that share pathways with RANBP1: view

Pathways by source for RANBP1 Gene

1 Cell Signaling Technology pathway for RANBP1 Gene
1 BioSystems pathway for RANBP1 Gene
2 KEGG pathways for RANBP1 Gene
2 Qiagen pathways for RANBP1 Gene

Gene Ontology (GO) - Biological Process for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006405 RNA export from nucleus IBA --
GO:0007051 spindle organization IEA,IBA --
GO:0007165 signal transduction TAS 16130169
GO:0016032 viral process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for SIGNOR curated interactions for RANBP1 Gene

Drugs & Compounds for RANBP1 Gene

(2) Drugs for RANBP1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for RANBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP1: view

Transcripts for RANBP1 Gene

Unigene Clusters for RANBP1 Gene

RAN binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP1 Gene

No ASD Table

Relevant External Links for RANBP1 Gene

GeneLoc Exon Structure for
RANBP1
ECgene alternative splicing isoforms for
RANBP1

Expression for RANBP1 Gene

mRNA expression in normal human tissues for RANBP1 Gene

Protein differential expression in normal tissues from HIPED for RANBP1 Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP1 Gene



SOURCE GeneReport for Unigene cluster for RANBP1 Gene Hs.24763

genes like me logo Genes that share expression patterns with RANBP1: view

Protein tissue co-expression partners for RANBP1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RANBP1 Gene

Orthologs for RANBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RANBP1 35
  • 86.73 (n)
  • 94.39 (a)
RANBP1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP1 35
  • 91.92 (n)
  • 97.42 (a)
RANBP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp1 35
  • 88.89 (n)
  • 95.45 (a)
Ranbp1 16
Ranbp1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RANBP1 35
  • 100 (n)
  • 100 (a)
RANBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp1 35
  • 88.5 (n)
  • 94.5 (a)
oppossum
(Monodelphis domestica)
Mammalia RANBP1 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP1 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP1 35
  • 81.44 (n)
  • 88.66 (a)
RANBP1 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76028 35
ranbp1 35
  • 73.91 (n)
  • 82.32 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.12411 35
ranbp1 35
  • 72.93 (n)
  • 74.62 (a)
ranbp1 36
  • 62 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8810 35
fruit fly
(Drosophila melanogaster)
Insecta Nup358 36
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-9 36
  • 1 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER002W 35
  • 59.37 (n)
  • 60.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17227g 35
  • 56.72 (n)
  • 61.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB1 35
  • 55.85 (n)
  • 54.97 (a)
YRB1 36
  • 5 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons SIRANBP 35
  • 53.98 (n)
  • 46.02 (a)
rice
(Oryza sativa)
Liliopsida Os03g0292800 35
  • 58.79 (n)
  • 50.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1880 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00443 35
  • 61.9 (n)
  • 60 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sbp1 35
  • 59.26 (n)
  • 56.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9803 36
  • 48 (a)
OneToOne
Species with no ortholog for RANBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP1 Gene

ENSEMBL:
Gene Tree for RANBP1 (if available)
TreeFam:
Gene Tree for RANBP1 (if available)

Paralogs for RANBP1 Gene

Paralogs for RANBP1 Gene

genes like me logo Genes that share paralogs with RANBP1: view

Variants for RANBP1 Gene

Sequence variations from dbSNP and Humsavar for RANBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036567 A breast cancer sample
rs5746863 - 20,125,431(-) GAATG(A/C/G/T)TGAGA reference, missense
rs100798 -- 20,124,206(+) AGGTT(G/T)TGGGT intron-variant
rs2238798 -- 20,120,206(+) AGGAA(A/G)GGGGC intron-variant
rs2238799 -- 20,121,802(+) ggggc(A/G)atctc intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RANBP1 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv914327 CNV Loss 21882294
nsv471183 CNV Loss 18288195
nsv834133 CNV Loss 17160897
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4856n71 CNV Loss 21882294
dgv4857n71 CNV Loss 21882294
dgv4858n71 CNV Loss 21882294
dgv4859n71 CNV Loss 21882294
dgv4860n71 CNV Loss 21882294
nsv914347 CNV Loss 21882294
esv2723994 CNV Deletion 23290073
esv2110469 CNV Deletion 18987734
esv2723996 CNV Deletion 23290073

Variation tolerance for RANBP1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.50% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RANBP1 Gene

Disorders for RANBP1 Gene

Relevant External Links for RANBP1

Genetic Association Database (GAD)
RANBP1
Human Genome Epidemiology (HuGE) Navigator
RANBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP1

No disorders were found for RANBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP1 Gene

Publications for RANBP1 Gene

  1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PMID: 7616957) Hayashi N. … Nishimoto T. (Mol. Gen. Genet. 1995) 2 3 4 23 67
  2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PMID: 10330396) Kehlenbach R.H. … Gerace L. (J. Cell Biol. 1999) 2 3 23
  3. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. (PMID: 19270727) Rensen W.M. … Lavia P. (Oncogene 2009) 3 23
  4. Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication. (PMID: 16041368) Wang W. … Wang X.W. (Nat. Cell Biol. 2005) 3 23
  5. Phosphorylation of RanGAP1 stabilizes its interaction with Ran and RanBP1. (PMID: 16428860) Takeda E. … Yoneda Y. (Cell Struct. Funct. 2005) 3 23

Products for RANBP1 Gene

Sources for RANBP1 Gene

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