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Aliases for RANBP1 Gene

Aliases for RANBP1 Gene

  • RAN Binding Protein 1 2 3
  • HTF9A 3 6
  • Ran-Specific GTPase-Activating Protein 3
  • HpaII Tiny Fragments Locus 9A 3
  • Ran-Binding Protein 1 4
  • RanBP1 4

External Ids for RANBP1 Gene

Summaries for RANBP1 Gene

Entrez Gene Summary for RANBP1 Gene

  • This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANBP1 Gene

RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Among its related pathways are Disease and Cytoskeletal Signaling. GO annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for RANBP1 Gene

  • Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane

Gene Wiki entry for RANBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP1 Gene

Genomics for RANBP1 Gene

Genomic Location for RANBP1 Gene

Start:
20,115,938 bp from pter
End:
20,127,357 bp from pter
Size:
11,420 bases
Orientation:
Plus strand

Genomic View for RANBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RANBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP1 Gene

Regulatory Elements for RANBP1 Gene

Proteins for RANBP1 Gene

  • Protein details for RANBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43487-RANG_HUMAN
    Recommended name:
    Ran-specific GTPase-activating protein
    Protein Accession:
    P43487
    Secondary Accessions:
    • Q53EY3

    Protein attributes for RANBP1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23310 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RANBP1 Gene

    Alternative splice isoforms for RANBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP1 Gene

Proteomics data for RANBP1 Gene at MOPED

Post-translational modifications for RANBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys50, Lys68, Lys76, Lys134, Lys150, and Lys183

No data available for DME Specific Peptides for RANBP1 Gene

Domains for RANBP1 Gene

Protein Domains for RANBP1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RANG_HUMAN
Domain:
  • Contains 1 RanBD1 domain.:
    • P43487
Family:
  • Belongs to the RANBP1 family.:
    • P43487
genes like me logo Genes that share domains with RANBP1: view

No data available for Gene Families for RANBP1 Gene

Function for RANBP1 Gene

Molecular function for RANBP1 Gene

GENATLAS Biochemistry: Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome condensation (CHC1L) in association with Ran/TC4
UniProtKB/Swiss-Prot Function: Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane

Gene Ontology (GO) - Molecular Function for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity TAS 7616957
GO:0005096 GTPase activator activity IEA --
GO:0008536 Ran GTPase binding TAS 7882974
genes like me logo Genes that share ontologies with RANBP1: view

Phenotypes for RANBP1 Gene

genes like me logo Genes that share phenotypes with RANBP1: view

Animal Models for RANBP1 Gene

MGI Knock Outs for RANBP1:

miRNA for RANBP1 Gene

miRTarBase miRNAs that target RANBP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RANBP1 Gene

Localization for RANBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RANBP1 Gene COMPARTMENTS Subcellular localization image for RANBP1 gene
Compartment Confidence
nucleus 4
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm TAS 16130169
GO:0005813 centrosome --
genes like me logo Genes that share ontologies with RANBP1: view

Pathways for RANBP1 Gene

genes like me logo Genes that share pathways with RANBP1: view

Pathways by source for RANBP1 Gene

2 Qiagen pathways for RANBP1 Gene
1 Cell Signaling Technology pathway for RANBP1 Gene
1 BioSystems pathway for RANBP1 Gene

Gene Ontology (GO) - Biological Process for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007051 spindle organization --
GO:0007165 signal transduction TAS 16130169
GO:0016032 viral process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0046604 positive regulation of mitotic centrosome separation --
genes like me logo Genes that share ontologies with RANBP1: view

Compounds for RANBP1 Gene

(1) HMDB Compounds for RANBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(4) Novoseek inferred chemical compound relationships for RANBP1 Gene

Compound -log(P) Hits PubMed IDs
gtp 73.1 11
gdp 57.6 2
leptomycin b 52.3 2
threonine 2.38 1
genes like me logo Genes that share compounds with RANBP1: view

Transcripts for RANBP1 Gene

Unigene Clusters for RANBP1 Gene

RAN binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP1 Gene

No ASD Table

Relevant External Links for RANBP1 Gene

GeneLoc Exon Structure for
RANBP1
ECgene alternative splicing isoforms for
RANBP1

Expression for RANBP1 Gene

mRNA expression in normal human tissues for RANBP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RANBP1 Gene

SOURCE GeneReport for Unigene cluster for RANBP1 Gene Hs.24763

genes like me logo Genes that share expressions with RANBP1: view

Orthologs for RANBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP1 36
  • 100 (n)
  • 100 (a)
RANBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RANBP1 36
  • 86.73 (n)
  • 94.39 (a)
RANBP1 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RANBP1 36
  • 91.92 (n)
  • 97.42 (a)
RANBP1 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ranbp1 36
  • 88.89 (n)
  • 95.45 (a)
Ranbp1 16
Ranbp1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP1 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP1 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ranbp1 36
  • 88.5 (n)
  • 94.5 (a)
chicken
(Gallus gallus)
Aves RANBP1 36
  • 81.44 (n)
  • 88.66 (a)
RANBP1 37
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RANBP1 37
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76028 36
ranbp1 36
  • 73.91 (n)
  • 82.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8810 36
zebrafish
(Danio rerio)
Actinopterygii Dr.12411 36
ranbp1 36
  • 72.93 (n)
  • 74.62 (a)
ranbp1 37
  • 62 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Nup358 37
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-9 37
  • 1 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER002W 36
  • 59.37 (n)
  • 60.58 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB1 36
  • 55.85 (n)
  • 54.97 (a)
YRB1 37
  • 5 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17227g 36
  • 56.72 (n)
  • 61.19 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SIRANBP 36
  • 53.98 (n)
  • 46.02 (a)
rice
(Oryza sativa)
Liliopsida Os03g0292800 36
  • 58.79 (n)
  • 50.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00443 36
  • 61.9 (n)
  • 60 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sbp1 36
  • 59.26 (n)
  • 56.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1880 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9803 37
  • 48 (a)
OneToOne
Species with no ortholog for RANBP1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP1 Gene

ENSEMBL:
Gene Tree for RANBP1 (if available)
TreeFam:
Gene Tree for RANBP1 (if available)

Paralogs for RANBP1 Gene

genes like me logo Genes that share paralogs with RANBP1: view

No data available for Paralogs for RANBP1 Gene

Variants for RANBP1 Gene

Sequence variations from dbSNP and Humsavar for RANBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs100798 -- 20,124,206(+) AGGTT(G/T)TGGGT intron-variant
rs175162 -- 20,125,730(+) ATTAG(G/T)TGTTG intron-variant
rs175163 -- 20,126,254(+) ATGTC(C/T)CTTCC intron-variant
rs375730 -- 20,123,457(+) ggggg(G/T)gtttg intron-variant
rs402331 -- 20,123,388(+) ggggg(G/T)gttgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RANBP1 Gene

Variant ID Type Subtype PubMed ID
nsv435744 CNV Deletion 17901297
nsv828938 CNV Gain 20364138
nsv828939 CNV Loss 20364138
nsv914327 CNV Loss 21882294
nsv471183 CNV Loss 18288195
nsv834133 CNV Loss 17160897
dgv1387e1 CNV Complex 17122850
dgv726n67 CNV Gain 20364138
dgv4855n71 CNV Loss 21882294
dgv4856n71 CNV Loss 21882294
dgv4857n71 CNV Loss 21882294
dgv4858n71 CNV Loss 21882294
dgv4859n71 CNV Loss 21882294
dgv4860n71 CNV Loss 21882294
nsv914347 CNV Loss 21882294
esv2723994 CNV Deletion 23290073
esv2110469 CNV Deletion 18987734
esv2723996 CNV Deletion 23290073

Relevant External Links for RANBP1 Gene

HapMap Linkage Disequilibrium report
RANBP1

Disorders for RANBP1 Gene

(1) University of Copenhagen DISEASES for RANBP1 Gene

(3) Novoseek inferred disease relationships for RANBP1 Gene

Disease -log(P) Hits PubMed IDs
shock 0 1
cancer 0 2
immunodeficiency 0 2

Relevant External Links for RANBP1

Genetic Association Database (GAD)
RANBP1
Human Genome Epidemiology (HuGE) Navigator
RANBP1
genes like me logo Genes that share disorders with RANBP1: view

No data available for UniProtKB/Swiss-Prot for RANBP1 Gene

Publications for RANBP1 Gene

  1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PMID: 7616957) Hayashi N. … Nishimoto T. (Mol. Gen. Genet. 1995) 2 3 4 23
  2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PMID: 10330396) Kehlenbach R.H. … Gerace L. (J. Cell Biol. 1999) 2 3 23
  3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran- GTP binding protein RanBP1. (PMID: 7882974) Bischoff F.R. … Ponstingl H. (EMBO J. 1995) 3 4 23
  4. Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. (PMID: 7891706) Ren M. … Rush M.G. (Mol. Cell. Biol. 1995) 3 23
  5. Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4. (PMID: 8255297) Coutavas E. … Rush M.G. (Nature 1993) 3 23

Products for RANBP1 Gene

Sources for RANBP1 Gene

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