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Aliases for RANBP1 Gene

Aliases for RANBP1 Gene

  • RAN Binding Protein 1 2 3 5
  • Testis Secretory Sperm-Binding Protein Li 221n 3
  • Ran-Specific GTPase-Activating Protein 3
  • HpaII Tiny Fragments Locus 9A 3
  • Ran-Binding Protein 1 4
  • RanBP1 4
  • HTF9A 3

External Ids for RANBP1 Gene

Previous GeneCards Identifiers for RANBP1 Gene

  • GC22P017045
  • GC22P018478
  • GC22P018479
  • GC22P003725

Summaries for RANBP1 Gene

Entrez Gene Summary for RANBP1 Gene

  • This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12, 17, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for RANBP1 Gene

RANBP1 (RAN Binding Protein 1) is a Protein Coding gene. Among its related pathways are E2F transcription factor network and HIV Life Cycle. GO annotations related to this gene include GTPase activator activity and GDP-dissociation inhibitor activity.

UniProtKB/Swiss-Prot for RANBP1 Gene

  • Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Gene Wiki entry for RANBP1 Gene

Additional gene information for RANBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RANBP1 Gene

Genomics for RANBP1 Gene

Regulatory Elements for RANBP1 Gene

Enhancers for RANBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H020494 1.8 FANTOM5 ENCODE dbSUPER 19.1 +379.9 379906 2 FEZF1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A MEF2D LZTR1 DGCR8 MED15 RPL7AP70 TRMT2A LOC100420177 RPL8P5 THAP7-AS1 THAP7 ENSG00000273343
GH22H019760 1.8 VISTA Ensembl ENCODE 18.7 -351.6 -351615 8 HDGF PKNOX1 ATF1 FOXA2 ARNT ZNF2 TCF12 GATA2 FOS ATF7 LINC01311 DGCR8 LOC100420177 TRMT2A ZDHHC8 RANBP1 RPL8P5 KLHL22 UFD1 ABHD17AP4
GH22H020114 1.4 ENCODE dbSUPER 19.8 +1.3 1308 4 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 LZTR1 TRMT2A MED15 TUBA3GP DGCR8 SCARF2 RPL7AP70 RANBP1 ESS2 LINC01311
GH22H020078 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -34.4 -34417 5 HNRNPUL1 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 DGCR8 TRMT2A LZTR1 RPL8P5 MED15 UFD1 RPL7AP70 ENSG00000273300 LOC100420177 RANBP1
GH22H019717 1 ENCODE 24.3 -397.3 -397252 2 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF2 ZNF121 ZNF143 ZNF207 ATF7 LINC01311 DGCR8 RANBP1 TRMT2A ZNF74 UFD1 ABHD17AP4 KLHL22 E2F6P1 ENSG00000273343
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RANBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RANBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143858 1562 2201 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9

Genomic Location for RANBP1 Gene

Chromosome:
22
Start:
20,115,938 bp from pter
End:
20,127,357 bp from pter
Size:
11,420 bases
Orientation:
Plus strand

Genomic View for RANBP1 Gene

Genes around RANBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RANBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RANBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RANBP1 Gene

Proteins for RANBP1 Gene

  • Protein details for RANBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43487-RANG_HUMAN
    Recommended name:
    Ran-specific GTPase-activating protein
    Protein Accession:
    P43487
    Secondary Accessions:
    • Q53EY3

    Protein attributes for RANBP1 Gene

    Size:
    201 amino acids
    Molecular mass:
    23310 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RANBP1 Gene

    Alternative splice isoforms for RANBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RANBP1 Gene

Post-translational modifications for RANBP1 Gene

  • Ubiquitination at isoforms=276 and Lys134
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RANBP1 (RANBP1)

No data available for DME Specific Peptides for RANBP1 Gene

Domains & Families for RANBP1 Gene

Gene Families for RANBP1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RANBP1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P43487

UniProtKB/Swiss-Prot:

RANG_HUMAN :
  • Belongs to the RANBP1 family.
Family:
  • Belongs to the RANBP1 family.
genes like me logo Genes that share domains with RANBP1: view

Function for RANBP1 Gene

Molecular function for RANBP1 Gene

GENATLAS Biochemistry:
Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome condensation (CHC1L) in association with Ran/TC4
UniProtKB/Swiss-Prot Function:
Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.

Phenotypes From GWAS Catalog for RANBP1 Gene

Gene Ontology (GO) - Molecular Function for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity IMP 7616957
GO:0005096 contributes_to GTPase activator activity IBA --
GO:0005515 protein binding IPI 7616957
GO:0008536 Ran GTPase binding TAS 7882974
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with RANBP1: view
genes like me logo Genes that share phenotypes with RANBP1: view

Animal Models for RANBP1 Gene

MGI Knock Outs for RANBP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RANBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RANBP1 Gene

Localization for RANBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RANBP1 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,TAS 16130169
GO:0005635 nuclear envelope TAS --
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005813 centrosome IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RANBP1 Gene

Pathways & Interactions for RANBP1 Gene

genes like me logo Genes that share pathways with RANBP1: view

Pathways by source for RANBP1 Gene

1 Cell Signaling Technology pathway for RANBP1 Gene
1 BioSystems pathway for RANBP1 Gene
2 KEGG pathways for RANBP1 Gene
2 Qiagen pathways for RANBP1 Gene

Gene Ontology (GO) - Biological Process for RANBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IBA --
GO:0006405 RNA export from nucleus IBA --
GO:0006511 ubiquitin-dependent protein catabolic process IBA --
GO:0006606 protein import into nucleus IBA --
GO:0007051 spindle organization IEA,IBA --
genes like me logo Genes that share ontologies with RANBP1: view

No data available for SIGNOR curated interactions for RANBP1 Gene

Drugs & Compounds for RANBP1 Gene

(4) Drugs for RANBP1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved Pharma Target 188
Guanosine triphosphate Experimental Pharma 0
Phenethyl isothiocyanate Investigational Pharma Target 12

(3) Additional Compounds for RANBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RANBP1: view

Transcripts for RANBP1 Gene

Unigene Clusters for RANBP1 Gene

RAN binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RANBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RANBP1 Gene

No ASD Table

Relevant External Links for RANBP1 Gene

GeneLoc Exon Structure for
RANBP1
ECgene alternative splicing isoforms for
RANBP1

Expression for RANBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RANBP1 Gene

Protein differential expression in normal tissues from HIPED for RANBP1 Gene

This gene is overexpressed in Bone (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RANBP1 Gene



Protein tissue co-expression partners for RANBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RANBP1 Gene:

RANBP1

SOURCE GeneReport for Unigene cluster for RANBP1 Gene:

Hs.24763

Evidence on tissue expression from TISSUES for RANBP1 Gene

  • Liver(4.5)
  • Heart(4.4)
  • Blood(4.2)
  • Nervous system(3.1)
  • Lung(2.6)
  • Spleen(2.3)
  • Intestine(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RANBP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RANBP1 Gene

Orthologs for RANBP1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RANBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RANBP1 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia RANBP1 33 34
  • 91.92 (n)
mouse
(Mus musculus)
Mammalia Ranbp1 33 16 34
  • 88.89 (n)
rat
(Rattus norvegicus)
Mammalia Ranbp1 33
  • 88.5 (n)
cow
(Bos Taurus)
Mammalia RANBP1 33 34
  • 86.73 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RANBP1 34
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RANBP1 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves RANBP1 33 34
  • 81.44 (n)
lizard
(Anolis carolinensis)
Reptilia RANBP1 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ranbp1 33
  • 73.91 (n)
MGC76028 33
zebrafish
(Danio rerio)
Actinopterygii ranbp1 34 33
  • 72.93 (n)
OneToOne
Dr.12411 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8810 33
fruit fly
(Drosophila melanogaster)
Insecta Nup358 34
OneToOne
worm
(Caenorhabditis elegans)
Secernentea npp-9 34
  • 1 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER002W 33
  • 59.37 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E17227g 33
  • 56.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YRB1 33 34
  • 55.85 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons SIRANBP 33
  • 53.98 (n)
rice
(Oryza sativa)
Liliopsida Os03g0292800 33
  • 58.79 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00443 33
  • 61.9 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sbp1 33
  • 59.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9803 34
  • 48 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1880 33
Species where no ortholog for RANBP1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RANBP1 Gene

ENSEMBL:
Gene Tree for RANBP1 (if available)
TreeFam:
Gene Tree for RANBP1 (if available)

Paralogs for RANBP1 Gene

genes like me logo Genes that share paralogs with RANBP1: view

No data available for Paralogs for RANBP1 Gene

Variants for RANBP1 Gene

Sequence variations from dbSNP and Humsavar for RANBP1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
VAR_036567 A breast cancer sample
rs1000071889 -- 20,120,598(+) GAGGG(C/T)GCCAG intron-variant
rs1000172388 -- 20,117,260(+) ACGCG(A/C)CGGAT intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000499497 -- 20,127,350(+) TGGAA(C/T)CTGGG downstream-variant-500B, utr-variant-3-prime
rs1001019119 -- 20,116,097(+) TCAGC(A/G)TAGGG upstream-variant-2KB, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RANBP1 Gene

Variant ID Type Subtype PubMed ID
dgv4480n100 CNV gain 25217958
dgv4481n100 CNV gain 25217958
dgv726n67 CNV gain 20364138
dgv7983n54 CNV gain 21841781
esv2110469 CNV deletion 18987734
esv2758825 CNV loss 17122850
esv3557940 CNV deletion 23714750
esv3647284 CNV gain 21293372
esv3893434 CNV gain 25118596
nsv1118943 CNV deletion 24896259
nsv1131651 CNV deletion 24896259
nsv471183 CNV loss 18288195
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953027 CNV deletion 24416366

Variation tolerance for RANBP1 Gene

Residual Variation Intolerance Score: 34.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RANBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RANBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RANBP1 Gene

Disorders for RANBP1 Gene

Relevant External Links for RANBP1

Genetic Association Database (GAD)
RANBP1
Human Genome Epidemiology (HuGE) Navigator
RANBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RANBP1

No disorders were found for RANBP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RANBP1 Gene

Publications for RANBP1 Gene

  1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PMID: 7616957) Hayashi N … Nishimoto T (Molecular & general genetics : MGG 1995) 2 3 4 22 60
  2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PMID: 10330396) Kehlenbach RH … Gerace L (The Journal of cell biology 1999) 2 3 22 60
  3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. (PMID: 7882974) Bischoff FR … Ponstingl H (The EMBO journal 1995) 3 4 22 60
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 45 60
  5. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. (PMID: 19270727) Rensen WM … Lavia P (Oncogene 2009) 3 22 60

Products for RANBP1 Gene

Sources for RANBP1 Gene

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