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RANBP1 Gene

protein-coding   GIFtS: 63
GCID: GC22P020103

RAN Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAN Binding Protein 11 2
HTF9A2 5
HpaII Tiny Fragments Locus 9A2
Ran-Specific GTPase-Activating Protein2
RanBP13
Ran-Binding Protein 13

External Ids:    HGNC: 98471   Entrez Gene: 59022   Ensembl: ENSG000000999017   OMIM: 6011805   UniProtKB: P434873   

Export aliases for RANBP1 gene to outside databases

Previous GC identifers: GC22P017045 GC22P018478 GC22P018479 GC22P003725


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RANBP1 Gene:
This gene encodes a protein that forms a complex with Ras-related nuclear protein (Ran) and metabolizes guanoside
triphosphate (GTP). This complex participates in the regulation of the cell cycle by controlling transport of
proteins and nucleic acids into the nucleus. There are multiple pseudogenes for this gene on chromosomes 9, 12,
17, and X. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for RANBP1 Gene:
RANBP1 (RAN binding protein 1) is a protein-coding gene. Diseases associated with RANBP1 include human t-cell leukemia virus type 1, and digeorge syndrome. GO annotations related to this gene include GDP-dissociation inhibitor activity and GTPase activator activity.

UniProtKB/Swiss-Prot: RANG_HUMAN, P43487
Function: Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced
by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the
progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear
membrane

Gene Wiki entry for RANBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011520.13  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RANBP1 gene promoter:
         SRF   Spz1   Pax-5   SRF (504 AA)   YY1   CREB   deltaCREB   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRANBP1 promoter sequence
   Search Chromatin IP Primers for RANBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RANBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

RANBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RANBP1 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P020103:  view genomic region     (about GC identifiers)

Start:
20,103,461 bp from pter      End:
20,114,878 bp from pter
Size:
11,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RANG_HUMAN, P43487 (See protein sequence)
Recommended Name: Ran-specific GTPase-activating protein  
Size: 201 amino acids; 23310 Da
2 PDB 3D structures from and Proteopedia for RANBP1:
1K5D (3D)        1K5G (3D)    

Explore the universe of human proteins at neXtProt for RANBP1: NX_P43487

Explore proteomics data for RANBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys50, Lys68, Lys76, Lys134, Lys150, Lys183
  • Modification sites at PhosphoSitePlus

  • See RANBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265568.1  NP_001265569.1  NP_001265570.1  NP_002873.1  

    ENSEMBL proteins: 
     ENSP00000404724   ENSP00000390139   ENSP00000384925   ENSP00000327583   ENSP00000395472  
     ENSP00000404126   ENSP00000400940   ENSP00000404298   ENSP00000413502   ENSP00000398300  
     ENSP00000401564  
    Reactome Protein details: P43487

    RANBP1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000156 Ran_bind_dom
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry P43487

    ProtoNet protein and cluster: P43487

    1 Blocks protein domain: IPB000156 RanBP1 domain

    UniProtKB/Swiss-Prot: RANG_HUMAN, P43487
    Similarity: Belongs to the RANBP1 family
    Similarity: Contains 1 RanBD1 domain


    RANBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RANG_HUMAN, P43487
    Function: Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced
    by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the
    progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear
    membrane

         Genatlas biochemistry entry for RANBP1:
    Ran (Ras-related small nuclear protein) binding protein 1,stimulating Ran GAP1-induced GTP hydrolysis by
    RAS-related protein Ran/TC4,also,in absence of RAS-GAP negative regulator of the regulator of chromosome
    condensation (CHC1L) in association with Ran/TC4

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005092GDP-dissociation inhibitor activity TAS7616957
    GO:0005096GTPase activator activity IEA--
    GO:0008536Ran GTPase binding TAS7882974
         
    RANBP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RANBP1:
     Decreased p24 protein expressi 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ranbp1):
     cellular  growth/size/body  reproductive system 

    RANBP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ranbp1tm1Yyo for RANBP1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RANBP1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RANBP1

    miRNA
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    miRTarBase miRNAs that target RANBP1:
    hsa-mir-24-3p (MIRT050368)

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    hsa-miR-623 hsa-miR-4277
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    cytoskeleton2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS16130169
    GO:0005635nuclear envelope TAS--
    GO:0005737cytoplasm TAS16130169
    GO:0005813centrosome IEA--

    RANBP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RANBP1 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.91
    Interactions of Rev with host cellular proteins0.91
    34-1BB Pathway
    SUMO Pathway0.30
    4Viral carcinogenesis
    Viral carcinogenesis
    5Ran Pathway
    Ran Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RANBP1
        Ran Pathway
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for RANBP1
        Cytoskeletal Signaling

    1 BioSystems Pathway for RANBP1
        E2F transcription factor network

    1 Reactome Pathway for RANBP1
        Rev-mediated nuclear export of HIV RNA


    2 Kegg Pathways  (Kegg details for RANBP1):
        HTLV-I infection
    Viral carcinogenesis


    RANBP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RANBP1
    Interactions:

        GeneGlobe Interaction Network for RANBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RANBP1 (P434871, 2, 3 ENSP000003275834) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANP628262, 3, ENSP000003961274MINT-73242 I2D: score=6 STRING: ENSP00000396127
    MPGP293721, 3, ENSP000002194314EBI-1032909,EBI-1043398 I2D: score=2 STRING: ENSP00000219431
    NAP1L4Q997333, ENSP000003699154I2D: score=5 STRING: ENSP00000369915
    RCC1P187543, ENSP000003629374I2D: score=3 STRING: ENSP00000362937
    CD93Q9NPY33, ENSP000002460064I2D: score=2 STRING: ENSP00000246006
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007051spindle organization IEA--
    GO:0007165signal transduction TAS16130169
    GO:0016032viral process TAS--
    GO:0046604positive regulation of mitotic centrosome separation IEA--
    GO:0046907intracellular transport IEA--

    RANBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RANBP1 (RANG)

    1 HMDB Compound for RANBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    4 Novoseek inferred chemical compound relationships for RANBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 73.1 17 10779340 (3), 10995230 (2), 10322113 (1), 9398678 (1) (see all 8)
    gdp 57.6 2 15454457 (1), 15733044 (1)
    leptomycin b 52.3 4 10779340 (1), 16041368 (1)
    threonine 2.38 1 15733044 (1)



    RANBP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RANBP1 gene (4 alternative transcripts): 
    NM_001278639.1  NM_001278640.1  NM_001278641.1  NM_002882.3  

    Unigene Cluster for RANBP1:

    RAN binding protein 1
    Hs.24763  [show with all ESTs]
    Unigene Representative Sequence: AK094410
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432879 ENST00000435265 ENST00000402752(uc011ahl.1 uc002zro.1 uc002zrp.3)
    ENST00000488484 ENST00000331821 ENST00000411892 ENST00000467920 ENST00000416427
    ENST00000421656 ENST00000423859(uc021wlq.1) ENST00000418705 ENST00000448394
    ENST00000486575 ENST00000430524
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    hsa-miR-623 hsa-miR-4277
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      QuantiTect SYBR Green Assays in human, mouse, rat RANBP1
      QuantiFast Probe-based Assays in human, mouse, rat RANBP1

    Additional mRNA sequence: 

    AK094410.1 AK097659.1 AK223506.1 AK293502.1 AK300927.1 BC071998.1 CR456556.1 D38076.1 
    X83617.1 

    19 DOTS entries:

    DT.100762584  DT.452618  DT.100821145  DT.100821133  DT.95158595  DT.95158593  DT.97797266  DT.120644455 
    DT.100821144  DT.120644518  DT.100037501  DT.65284203  DT.97820864  DT.100037502  DT.121179473  DT.91781574 
    DT.95158591  DT.97799420  DT.91781588 

    Selected AceView cDNA sequences (see all 357):

    BE221519 AI334312 X83617 BU187626 BU677880 CB125350 AI638429 CB157924 
    BG576793 CR590513 BQ927398 BM824732 BQ684884 CA421993 AA382903 BE348381 
    AI589059 CD368915 CA420464 AI335716 CA391598 AI186665 CK824836 AV655673 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RANBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGAAAAAGT
    RANBP1 Expression
    About this image

    RANBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RANBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.24763
        Custom PCR Arrays for RANBP1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RANBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RANBP1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ranbp11 , 5 RAN binding protein 11, 5 88.89(n)1
    95.45(a)1
      16 (11.30 cM)5
    193851  NM_011239.21  NP_035369.21 
     182397845 
    chicken
    (Gallus gallus)
    Aves RANBP11 RAN binding protein 1 81.44(n)
    88.66(a)
      416787  NM_001006183.1  NP_001006183.1 
    lizard
    (Anolis carolinensis)
    Reptilia RANBP16
    RAN binding protein 1
    81(a)
    1 ↔ 1
    GL343364.1(1027192-1031590)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC760282 hypothetical protein MGC76028 76.49(n)    BC061426.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.124112 Danio rerio Ran binding protein 1 mRNA, complete cds 73.19(n)    AF364085.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Nup3586
    Nucleoporin 358

    1 ↔ 1
    3R(21075316-21084394)
    worm
    (Caenorhabditis elegans)
    Secernentea npp-96
    Protein NPP-9, isoform a (npp-9) mRNA, complete cd...
    1(a)
    1 ↔ 1
    III(3400641-3404479) WBGene00003795
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YRB11 YRB1 55.85(n)
    54.97(a)
      851565   NP_010285.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SIRANBP1 SIRANBP 53.98(n)
    46.02(a)
      837225  NM_100588.3  NP_172194.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02928001 Os03g0292800 58.79(n)
    50.55(a)
      4332513  NM_001056341.1  NP_001049806.1 


    ENSEMBL Gene Tree for RANBP1 (if available)
    TreeFam Gene Tree for RANBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RANBP1 gene
    6 SIMAP similar genes for RANBP1 using alignment to 10 protein entries:     RANG_HUMAN (see all proteins):
    RANBP2    RGPD2    RGPD3    RGPD8    RGPD4    RGPD1

    RANBP1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for RANBP1
    PGOHUM00000239523 PGOHUM00000237269 PGOHUM00000237510 PGOHUM00000245168 PGOHUM00000236330


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RANBP1 (see all 12)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365674
    A breast cancer sample4--see VAR_0365672 E D mis40--------
    rs3685673831,2
    C--20110247(+) GTGCT-/TGTG  
            
    GTGTG
    1 -- int10--------
    rs1452559581,2
    C--20110314(+) TGTCT-/GGGGGG 1 -- int10--------
    rs1477644461,2
    C--20110334(+) GGGTA-/TGTGTGT 1 -- int10--------
    rs1435584101,2
    C--20110826(+) TGTCT-/AAGGGG 1 -- int10--------
    rs607927811,2
    C--20111970(+) CCCCC-/C/CC  
            
    AGCTC
    1 -- int10--------
    rs57468631,2,4
    ----see VAR_0536292 mis40--------
    rs3685475161,2
    ----20114894(+) TGTGT-/GTACAGG 1 -- ds50010--------
    rs3689388341,2
    ----20110335(+) GGGGT-/TGGTGTA 1 -- int10--------
    rs668132441,2
    ----20109088(+) TTTTA-/TAAATA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RANBP1 (20103461 - 20114878 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RANBP1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723994CNV Deletion23290073
    esv2723996CNV Deletion23290073
    esv2110469CNV Deletion18987734
    nsv435744CNV Deletion17901297
    dgv4857n71CNV Loss21882294
    nsv471183CNV Loss18288195
    nsv914327CNV Loss21882294
    dgv4859n71CNV Loss21882294
    dgv4858n71CNV Loss21882294
    nsv914347CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601180    OMIM disorders: --

    10 diseases for RANBP1:    
    About MalaCards
    human t-cell leukemia virus type 1    digeorge syndrome    breast and colorectal cancer    t-cell leukemia
    cystic fibrosis    hiv-1    endotheliitis    leukemia
    breast cancer    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for RANBP1:
    Velocardiofacial syndrome

    RANBP1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RANBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 0 1 12872216 (1)
    cancer 0 2 19270727 (2)
    immunodeficiency 0 3 9111043 (2)

    Genetic Association Database (GAD): RANBP1
    Human Genome Epidemiology (HuGE) Navigator: RANBP1 (4 documents)

    Export disorders for RANBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RANBP1 gene, integrated from 10 sources (see all 131):
    (articles sorted by number of sources associating them with RANBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. (PubMed id 7616957)1, 2, 3, 9 Hayashi N.... Nishimoto T. (Mol. Gen. Genet. 1995)
    2. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. (PubMed id 10330396)1, 3, 9 Kehlenbach R.H....Gerace L. (J. Cell Biol. 1999)
    3. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran- GTP binding protein RanBP1. (PubMed id 7882974)1, 2, 9 Bischoff F.R.... Ponstingl H. (EMBO J. 1995)
    4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    5. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    6. Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1. (PubMed id 9315840)1, 9 Kuhlmann J....Wittinghofer A. (Biochemistry 1997)
    7. RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. (PubMed id 19270727)1, 9 Rensen W.M....Lavia P. (Oncogene 2009)
    8. RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import. (PubMed id 8909533)1, 9 Chi N.C....Adam S.A. (J. Cell Biol. 1996)
    9. Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. (PubMed id 10779340)1, 9 Plafker K. and Macara I.G. (Mol. Cell. Biol. 2000)
    10. Mammalian RanBP1 regulates centrosome cohesion during mitosis. (PubMed id 12840069)1, 9 Di Fiore B....Lavia P. (J. Cell. Sci. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 5902 HGNC: 9847 AceView: RANBP1 Ensembl:ENSG00000099901 euGenes: HUgn5902
    ECgene: RANBP1 Kegg: 5902 H-InvDB: RANBP1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RANBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RANBP1 gene:
    Search GeneIP for patents involving RANBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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