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Aliases for RAN Gene

Aliases for RAN Gene

  • RAN, Member RAS Oncogene Family 2 3 5
  • Androgen Receptor-Associated Protein 24 3 4
  • Ras-Related Nuclear Protein 3 4
  • Ras-Like Protein TC4 3 4
  • GTPase Ran 3 4
  • ARA24 3 4
  • GTP-Binding Nuclear Protein Ran 3
  • Guanosine Triphosphatase Ran 3
  • Member RAS Oncogene Family 3
  • OK/SW-Cl.81 3
  • RanGTPase 3
  • Gsp1 3
  • TC4 3

External Ids for RAN Gene

Previous GeneCards Identifiers for RAN Gene

  • GC12P129785
  • GC12P131119
  • GC12P030224
  • GC12P129709
  • GC12P129881
  • GC12P131356
  • GC12P128338

Summaries for RAN Gene

Entrez Gene Summary for RAN Gene

  • RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAN Gene

RAN (RAN, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAN include Teratocarcinoma and Goodpasture Syndrome. Among its related pathways are Ran Pathway and mRNA Capping. GO annotations related to this gene include poly(A) RNA binding and GTP binding. An important paralog of this gene is RABL2B.

UniProtKB/Swiss-Prot for RAN Gene

  • GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.

  • The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).

Gene Wiki entry for RAN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAN Gene

Genomics for RAN Gene

Regulatory Elements for RAN Gene

Enhancers for RAN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G130870 1.1 ENCODE 0.7 +0.6 633 4.6 HDGF PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 STX2 ENSG00000256250 ENSG00000256299 RAN GC12P130907
GH12G130878 1.3 Ensembl ENCODE 0.4 +7.7 7677 2.9 PKNOX1 WRNIP1 SIN3A ZNF766 KLF13 ZNF263 TAF15 JUNB TBX21 ZNF592 STX2 ENSG00000255933 ENSG00000256299 SFSWAP ENSG00000256250 RAN GC12P130907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAN on UCSC Golden Path with GeneCards custom track

Promoters for RAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000270841 621 2201 HDGF MLX WRNIP1 SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143 KLF13
ENSR00000059308 -779 201 HDGF PKNOX1 MLX ARNT ZFP64 WRNIP1 ARID4B SIN3A DMAP1 CBX5

Genomic Location for RAN Gene

Chromosome:
12
Start:
130,871,879 bp from pter
End:
130,877,678 bp from pter
Size:
5,800 bases
Orientation:
Plus strand

Genomic View for RAN Gene

Genes around RAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAN Gene

Proteins for RAN Gene

  • Protein details for RAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62826-RAN_HUMAN
    Recommended name:
    GTP-binding nuclear protein Ran
    Protein Accession:
    P62826
    Secondary Accessions:
    • A8K3Z8
    • P17080
    • P28746
    • P28747
    • Q6IPB2
    • Q86V08
    • Q8NI90
    • Q9CSP3
    • Q9CWI7
    • Q9CZA2
    • Q9UDJ5
    • Q9UEU9

    Protein attributes for RAN Gene

    Size:
    216 amino acids
    Molecular mass:
    24423 Da
    Quaternary structure:
    • Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, RAN, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, RAN and XPO1. Interacts with RANBP10. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and isoform 2 of VRK2. Interacts with NEMP1 and KPNB1 (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (PubMed:9822603, PubMed:10679025). Interacts with CAPG; mediates CAPG nuclear import (PubMed:10679025).
    • (Microbial infection) In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1.
    SequenceCaution:
    • Sequence=BAB93486.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAN Gene

neXtProt entry for RAN Gene

Post-translational modifications for RAN Gene

  • Ubiquitination at Lys23, isoforms=38, Lys60, isoforms=99, Lys123, Lys127, and Lys141
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAN (RAN)

No data available for DME Specific Peptides for RAN Gene

Domains & Families for RAN Gene

Gene Families for RAN Gene

Protein Domains for RAN Gene

Graphical View of Domain Structure for InterPro Entry

P62826

UniProtKB/Swiss-Prot:

RAN_HUMAN :
  • Belongs to the small GTPase superfamily. Ran family.
Family:
  • Belongs to the small GTPase superfamily. Ran family.
genes like me logo Genes that share domains with RAN: view

Function for RAN Gene

Molecular function for RAN Gene

GENATLAS Biochemistry:
Ras related GTPase component of the nuclear protein complex (NPC) mediating nucleocytoplasmic transport of proteins and ribonucleoproteins,expressed in a human teratocarcinoma cell line and in a range of human cell types
UniProtKB/Swiss-Prot Function:
GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.
UniProtKB/Swiss-Prot Function:
The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). Acts as a negative regulator of the kinase activity of VRK1 and VRK2 (PubMed:18617507). Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases (PubMed:10400640).

Gene Ontology (GO) - Molecular Function for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding IDA 11336674
GO:0003682 chromatin binding TAS 1961752
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RAN: view
genes like me logo Genes that share phenotypes with RAN: view

Animal Model Products

CRISPR Products

miRNA for RAN Gene

miRTarBase miRNAs that target RAN

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAN
  • Applied Biological Materials Clones for RAN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAN Gene

Localization for RAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAN Gene

Nucleus. Nucleus envelope. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250 UniProtKB:P62827}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAN gene
Compartment Confidence
extracellular 5
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin IDA 1961752
GO:0001673 male germ cell nucleus IEA --
GO:0002177 manchette IEA --
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 9822603
genes like me logo Genes that share ontologies with RAN: view

Pathways & Interactions for RAN Gene

genes like me logo Genes that share pathways with RAN: view

SIGNOR curated interactions for RAN Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0000278 mitotic cell cycle TAS 8421051
GO:0006259 DNA metabolic process TAS 8421051
genes like me logo Genes that share ontologies with RAN: view

Drugs & Compounds for RAN Gene

(14) Drugs for RAN Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(10) Additional Compounds for RAN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAN: view

Transcripts for RAN Gene

Unigene Clusters for RAN Gene

RAN, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAN
  • Applied Biological Materials Clones for RAN

Alternative Splicing Database (ASD) splice patterns (SP) for RAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3: -
SP4: - - - - - - -
SP5:
SP6:

Relevant External Links for RAN Gene

GeneLoc Exon Structure for
RAN
ECgene alternative splicing isoforms for
RAN

Expression for RAN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAN Gene



Protein tissue co-expression partners for RAN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAN Gene:

RAN

SOURCE GeneReport for Unigene cluster for RAN Gene:

Hs.10842

mRNA Expression by UniProt/SwissProt for RAN Gene:

P62826-RAN_HUMAN
Tissue specificity: Expressed in a variety of tissues.

Evidence on tissue expression from TISSUES for RAN Gene

  • Nervous system(5)
  • Liver(4.9)
  • Skin(4.9)
  • Blood(4.7)
  • Lung(4.6)
  • Eye(3.7)
  • Intestine(3.7)
  • Pancreas(3.7)
  • Kidney(3.6)
  • Stomach(2.6)
  • Heart(2.2)
  • Spleen(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with RAN: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAN Gene

Orthologs for RAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAN 34 35
  • 99.85 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAN 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700009N14Rik 35
  • 93 (a)
OneToOne
Ran 34 16
  • 89.66 (n)
cow
(Bos Taurus)
Mammalia RAN 34 35
  • 92.75 (n)
rat
(Rattus norvegicus)
Mammalia Ran 34
  • 89.2 (n)
dog
(Canis familiaris)
Mammalia RAN 34 35
  • 87.5 (n)
chicken
(Gallus gallus)
Aves RAN 34 35
  • 88.58 (n)
lizard
(Anolis carolinensis)
Reptilia RAN 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ran 34
  • 84.1 (n)
Str.6581 34
African clawed frog
(Xenopus laevis)
Amphibia ran-1-prov 34
zebrafish
(Danio rerio)
Actinopterygii ran 34 35
  • 79.75 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007699 34
  • 75.73 (n)
fruit fly
(Drosophila melanogaster)
Insecta ran 34
  • 71.91 (n)
ran-like 36 35
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea ran-1 36 34 35
  • 73.95 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GSP2 35
  • 79 (a)
OneToMany
GSP1 34 35
  • 70.75 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05126g 34
  • 72.06 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR294C 34
  • 71.57 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAN2 34
  • 71.22 (n)
rice
(Oryza sativa)
Liliopsida Os01g0611100 34
  • 68.93 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spi1 34
  • 69.03 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09269 34
  • 68.46 (n)
Species where no ortholog for RAN was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAN Gene

ENSEMBL:
Gene Tree for RAN (if available)
TreeFam:
Gene Tree for RAN (if available)

Paralogs for RAN Gene

Paralogs for RAN Gene

genes like me logo Genes that share paralogs with RAN: view

Variants for RAN Gene

Sequence variations from dbSNP and Humsavar for RAN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000496344 -- 130,874,054(+) ATGTT(G/T)CCCAT intron-variant
rs1000657044 -- 130,876,232(+) CATTC(C/G)CATTC utr-variant-3-prime
rs1000708796 -- 130,876,447(+) GTCAC(A/G)CAAAC utr-variant-3-prime
rs1001226339 -- 130,876,231(+) TCATT(C/T)CCATT utr-variant-3-prime
rs1001271444 -- 130,871,845(+) CTTGC(C/G)TACGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAN Gene

Variant ID Type Subtype PubMed ID
nsv1070149 CNV deletion 25765185
nsv1112627 CNV deletion 24896259
nsv983375 CNV duplication 23825009

Variation tolerance for RAN Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAN Gene

Human Gene Mutation Database (HGMD)
RAN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAN Gene

Disorders for RAN Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
goodpasture syndrome
  • anti-glomerular basement membrane disease
legionaire disease
  • legionnaires' disease
- elite association - COSMIC cancer census association via MalaCards
Search RAN in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAN

Genetic Association Database (GAD)
RAN
Human Genome Epidemiology (HuGE) Navigator
RAN
Tumor Gene Database (TGDB):
RAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAN
genes like me logo Genes that share disorders with RAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAN Gene

Publications for RAN Gene

  1. A new role for nuclear transport factor 2 and Ran: nuclear import of CapG. (PMID: 18266911) Van Impe K. … Gettemans J. (Traffic 2008) 3 4 22 64
  2. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-Garcia M. … Lazo P.A. (Mol. Cell. Proteomics 2008) 3 4 22 64
  3. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. (PMID: 10078529) Vetter I.R. … Wittinghofer A. (Nature 1999) 3 4 22 64
  4. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PMID: 9837918) Askjaer P. … Kjems J. (J. Biol. Chem. 1998) 3 4 22 64
  5. Crystal structure of the nuclear Ras-related protein Ran in its GDP- bound form. (PMID: 7885480) Scheffzek K. … Wittinghofer A. (Nature 1995) 3 4 22 64

Products for RAN Gene

  • Addgene plasmids for RAN

Sources for RAN Gene

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