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RAN Gene

protein-coding   GIFtS: 69
GCID: GC12P131356

RAN, Member RAS Oncogene Family

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAN, Member RAS Oncogene Family1 2     OK/SW-cl.812
ARA242 3 5     RanGTPase2
Androgen Receptor-Associated Protein 242 3     TC42
Ras-Like Protein TC42 3     GTP-Binding Nuclear Protein Ran2
Ras-Related Nuclear Protein2 3     Guanosine Triphosphatase Ran2
GTPase Ran2 3     Member RAS Oncogene Family2
Gsp12     

External Ids:    HGNC: 98461   Entrez Gene: 59012   Ensembl: ENSG000001323417   OMIM: 6011795   UniProtKB: P628263   

Export aliases for RAN gene to outside databases

Previous GC identifers: GC12P129785 GC12P131119 GC12P030224 GC12P129709 GC12P129881 GC12P128338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAN Gene:
RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is
essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also
involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the
presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its
many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and
organization of the microtubule network independently of its role in the nucleus-cytosol exchange of
macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1
generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of
microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of
polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's
disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine
expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the
development of Kennedy's disease. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAN Gene:
RAN (RAN, member RAS oncogene family) is a protein-coding gene. Diseases associated with RAN include kennedy's disease, and spinal-bulbar muscular atrophy. GO annotations related to this gene include transcription coactivator activity and GTP binding.

UniProtKB/Swiss-Prot: RAN_HUMAN, P62826
Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the
nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to
help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity
of VRK1 and VRK2
Function: Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR
increases

Gene Wiki entry for RAN (Ran) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAN gene promoter:
         GR   Max   AP-1   ATF-2   GR-alpha   c-Jun   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAN promoter sequence
   Search Chromatin IP Primers for RAN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.33   HGNC cytogenetic band: 12q24.33

RAN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P131356:  view genomic region     (about GC identifiers)

Start:
131,356,424 bp from pter      End:
131,362,223 bp from pter
Size:
5,800 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RAN_HUMAN, P62826 (See protein sequence)
Recommended Name: GTP-binding nuclear protein Ran  
Size: 216 amino acids; 24423 Da
Subunit: Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The
interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9,
Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export
receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and
XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a
Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. Interacts in its
GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction
requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with
MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and
isoform 2 of VRK2
Sequence caution: Sequence=BAB93486.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Selected PDB 3D structures from and Proteopedia for RAN (see all 35):
1I2M (3D)        1IBR (3D)        1K5D (3D)        1K5G (3D)        1QBK (3D)        1RRP (3D)    
Secondary accessions: A8K3Z8 P17080 P28746 P28747 Q6IPB2 Q86V08 Q8NI90 Q9CSP3 Q9CWI7 Q9CZA2
Q9UDJ5 Q9UEU9

Explore the universe of human proteins at neXtProt for RAN: NX_P62826

Explore proteomics data for RAN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys23, Lys38, Lys60, Lys99, Lys123, Lys127, Lys134, Lys141, Lys142, Lys152,
                                 Lys159
  • Modification sites at PhosphoSitePlus

  • See RAN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006316.1  
    ENSEMBL proteins: 
     ENSP00000446215   ENSP00000396127   ENSP00000437950   ENSP00000441210   ENSP00000376176  
     ENSP00000444042   ENSP00000376174   ENSP00000254675  
    Reactome Protein details: P62826

    RAN Human Recombinant Protein Products:

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    Novus Biologicals RAN Proteins
    Novus Biologicals RAN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for RAN
    Browse Proteins at Cloud-Clone Corp.

    RAN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAN
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    Cell Signaling Technology (CST) Antibodies for RAN 
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    Novus Biologicals RAN Antibodies
    Search for Antibodies for RAN at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for RAN
    LSBio Antibodies in human, mouse, rat for RAN

    RAN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAN
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002041 Ran_GTPase
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P62826

    ProtoNet protein and cluster: P62826

    UniProtKB/Swiss-Prot: RAN_HUMAN, P62826
    Similarity: Belongs to the small GTPase superfamily. Ran family


    RAN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAN_HUMAN, P62826
    Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the
    nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).
    The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to
    help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity
    of VRK1 and VRK2
    Function: Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR
    increases

         Genatlas biochemistry entry for RAN:
    Ras related GTPase component of the nuclear protein complex (NPC) mediating nucleocytoplasmic transport of
    proteins and ribonucleoproteins,expressed in a human teratocarcinoma cell line and in a range of human cell types

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS1961752
    GO:0003713transcription coactivator activity NAS15572661
    GO:0003924GTPase activity TAS10400640
    GO:0005515protein binding IPI10353245
    GO:0005525GTP binding IDA1961752
         
    RAN for ontologies           About GeneDecksing


    Phenotypes:
         8 GenomeRNAi human phenotypes for RAN:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased homologous recombina  Decreased viability 
     Decreased viability of wild-ty  Increased gamma-H2AX phosphory  Increased number of mitotic ce  S arrest 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAN

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAN:
    hsa-mir-500a-3p (MIRT041154), hsa-mir-149-5p (MIRT045558), hsa-mir-615-3p (MIRT040262), hsa-mir-1250-5p (MIRT035863), hsa-mir-29a-3p (MIRT001196), hsa-mir-92b-3p (MIRT040590), hsa-mir-22-5p (MIRT038960), hsa-mir-744-5p (MIRT037549), hsa-mir-320a (MIRT044572), hsa-mir-16-5p (MIRT051173), hsa-mir-31-3p (MIRT038929), hsa-mir-1260b (MIRT052689), hsa-mir-186-5p (MIRT021084), hsa-mir-339-5p (MIRT042737)

    Block miRNA regulation of human, mouse, rat RAN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAN (see all 18):
    hsa-miR-495 hsa-miR-181c hsa-miR-513a-5p hsa-miR-134 hsa-miR-197 hsa-miR-766 hsa-miR-548a-3p hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidRAN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAN
    Predesigned siRNA for gene silencing in human, mouse, rat RAN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAN

    Clone
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    OriGene clones in human, mouse for RAN (see all 7)
    OriGene ORF clones in mouse, rat for RAN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAN (NM_006325)
    Sino Biological Human cDNA Clone for RAN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAN

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAN_HUMAN, P62826: Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By
    similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in
    melanosome fractions from stage I to stage IV
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton2
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000785colocalizes with chromatin IDA1961752
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005643nuclear pore NAS8421051
    GO:0005654nucleoplasm TAS--

    RAN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAN About   (see all 27)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sumoylation by RanBP2 regulates transcriptional repression
    Sumoylation by RanBP2 regulates transcriptional repression
    miRNA Biogenesis0.00
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.91
    NEP/NS2 Interacts with the Cellular Export Machinery0.91
    Nuclear import of Rev protein0.91
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Interactions of Rev with host cellular proteins0.91
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    4Regulatory RNA pathways
    Regulatory RNA pathways0.88
    MicroRNA (miRNA) Biogenesis0.88
    5Influenza Viral RNA Transcription and Replication
    Influenza Life Cycle0.82
    Influenza Infection0.80

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAN
        SMAD Signaling Network
    Ran Pathway
    JAK-STAT Pathway
    SUMO Pathway

    2 Cell Signaling Technology (CST) Pathways for RAN
        Cell Cycle / Checkpoint Control
    Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RAN
        Cell cycle Spindle assembly and chromosome separation

    Selected BioSystems Pathways for RAN (see all 9)
        Androgen receptor signaling pathway
    miRNA Biogenesis
    Aurora A signaling
    Signaling events mediated by HDAC Class I
    Role of Calcineurin-dependent NFAT signaling in lymphocytes


    5 Reactome Pathways for RAN
        Rev-mediated nuclear export of HIV RNA
    Nuclear import of Rev protein
    MicroRNA (miRNA) biogenesis
    NEP/NS2 Interacts with the Cellular Export Machinery
    Regulation of cholesterol biosynthesis by SREBP (SREBF)


    4 Kegg Pathways  (Kegg details for RAN):
        Ribosome biogenesis in eukaryotes
    RNA transport
    HTLV-I infection
    Epstein-Barr virus infection


    RAN for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAN
    Interactions:

        GeneGlobe Interaction Network for RAN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAN (P628261, 2, 3 ENSP000003961274) via UniProtKB, MINT, STRING, and/or I2D (see all 350)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RANBP1P434872, 3, ENSP000003275834MINT-73242 I2D: score=6 STRING: ENSP00000327583
    VRK1Q999861, 3, ENSP000002166394EBI-286642,EBI-1769146 I2D: score=2 STRING: ENSP00000216639
    KIAA1377Q9P2H02, 3MINT-63977 I2D: score=4 
    IPO13O948291, 2, 3, ENSP000003614184EBI-286642,EBI-747310 MINT-8107594 MINT-8107327 MINT-8109968 I2D: score=1 STRING: ENSP00000361418
    ENSG00000204221O152133I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0006259DNA metabolic process TAS8421051
    GO:0006405RNA export from nucleus ----
    GO:0006606protein import into nucleus ----
    GO:0006611protein export from nucleus IDA16449645

    RAN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAN

    1 HMDB Compound for RAN    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for RAN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    Selected Novoseek inferred chemical compound relationships for RAN gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 79.5 104 10078529 (4), 10779340 (4), 7548002 (4), 10471274 (3) (see all 50)
    leptomycin b 70.7 4 10779340 (1), 16319068 (1), 10601307 (1), 15020682 (1)
    gdp 70.6 37 9843686 (3), 7548002 (3), 7885480 (2), 9121474 (2) (see all 18)
    xanthosine 5'-triphosphate 69 2 9003787 (1)
    gppnhp 53.1 3 10078529 (1), 10367892 (1)
    nocodazole 30 1 15522227 (1)
    guanosine 22 3 16123300 (1), 9188526 (1), 10334990 (1)
    digitonin 17.7 1 9585406 (1)
    oligonucleotide 12.1 1 1421173 (1)
    topotecan 9.42 1 9779879 (1)



    RAN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAN gene: 
    NM_006325.3  

    Unigene Cluster for RAN:

    RAN, member RAS oncogene family
    Hs.10842  [show with all ESTs]
    Unigene Representative Sequence: AF052578
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543796(uc001uir.3) ENST00000448750(uc010tbk.2) ENST00000536606
    ENST00000537745 ENST00000541630(uc010tbl.2) ENST00000477395 ENST00000392369(uc001uis.3)
    ENST00000535090 ENST00000541679 ENST00000464211 ENST00000392367 ENST00000539498
    ENST00000254675
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAN (see all 18):
    hsa-miR-495 hsa-miR-181c hsa-miR-513a-5p hsa-miR-134 hsa-miR-197 hsa-miR-766 hsa-miR-548a-3p hsa-miR-4274
    SwitchGear 3'UTR luciferase reporter plasmidRAN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAN
    Clone
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    OriGene ORF clones in mouse, rat for RAN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAN (NM_006325)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAN
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAN
      QuantiTect SYBR Green Assays in human, mouse, rat RAN
      QuantiFast Probe-based Assays in human, mouse, rat RAN

    Additional mRNA sequence: 

    AB062399.1 AF052578.1 AF054183.1 AF501887.1 AK300934.1 AK311223.1 AK312466.1 AK316193.1 
    AL357616.1 BC000852.1 BC004272.1 BC014518.2 BC014901.2 BC016654.1 BC022813.1 BC051908.2 
    BC072000.1 BT007271.1 CR450347.1 M31469.1 

    Selected DOTS entries (see all 46):

    DT.100694739  DT.100694752  DT.91792761  DT.100694744  DT.100694740  DT.91792616  DT.91793048  DT.100694747 
    DT.100045568  DT.121186242  DT.121186243  DT.91792994  DT.95071151  DT.121345809  DT.95162203  DT.120540 
    DT.100694751  DT.121186328  DT.121345753  DT.91792582  DT.95162201  DT.100694756  DT.100694763  DT.100872679 

    Selected AceView cDNA sequences (see all 2135):

    BX379286 CR600935 BE257699 BG686238 CB142489 BU168974 BG684002 BU175174 
    BU734837 BE841067 BG108341 BU844482 BG751817 BQ069884 BM705550 BQ644759 
    BU153582 CF454892 BG684701 BG257596 BQ053835 BU630721 BM927880 BQ774686 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAN (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
    SP1:                    -                                                               
    SP2:                    -     -                                                         
    SP3:                    -                                                               
    SP4:                    -           -     -     -     -     -     -                     
    SP5:                                                                                    


    ECgene alternative splicing isoforms for RAN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAN expression in normal human tissues (normalized intensities)      RAN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTCATCT
    RAN Expression
    About this image


    RAN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Prosencephalon
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Tonsil (Hematopoietic System)
    RAN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.10842

    UniProtKB/Swiss-Prot: RAN_HUMAN, P62826
    Tissue specificity: Expressed in a variety of tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAN gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ran1 , 5 RAN, member RAS oncogene family1, 5 89.66(n)1
    100(a)1
      5 (67.99 cM)5
    193841  NM_009391.31  NP_033417.11 
     1290200695 
    chicken
    (Gallus gallus)
    Aves RAN1 RAN, member RAS oncogene family 88.58(n)
    98.61(a)
      396193  NM_205258.2  NP_990589.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAN6
    RAN, member RAS oncogene family
    97(a)
    1 ↔ 1
    GL343364.1(465-6546)
    African clawed frog
    (Xenopus laevis)
    Amphibia ran-1-prov2 RAN, member RAS oncogene family 82.73(n)    AB030945.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ran2 ras-related nuclear protein 81.08(n)   30572  BC058047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ran-like3
    ran1
    RAN small monomeric GTPase3
    ran1
    60(a)3
    71.91(n)1
    87.04(a)1
      71D33
    440721  NM_167272.21  NP_727499.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ran-11 , 3 GTP-binding protein3
    ran-11
    93(a)3
    73.95(n)1
    89.81(a)1
      III(10818478-10819656)3
    1765031  NM_066968.51  NP_499369.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GSP2(YOR185C)4
    GSP11
    GTP binding protein (mammalian Ranp homolog) involved more4
    GSP11
    70.75(n)1
    83.02(a)1
      15(682106-681444)4
    8510001  NP_013396.11  8543574 
     NP_014828.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAN21 RAN2 71.22(n)
    78.05(a)
      832124  NM_122009.3  NP_197502.1 
    rice
    (Oryza sativa)
    Liliopsida AB015287.12   -- 77.07(n)    AB015287.1 


    ENSEMBL Gene Tree for RAN (if available)
    TreeFam Gene Tree for RAN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAN gene
    Selected SIMAP similar genes for RAN using alignment to 6 protein entries:     RAN_HUMAN (see all proteins) (see all similar genes):
    RANP1    TC4    RAP2A    DKFZp547A0616    RAP2C    RAB11A
    RAB27A    RAP2B    RAB7A    RAB15    RAB3A    DKFZp686J06205
    RAB21    RAB36    RAB38    RAB13    RAP1B    RAB43

    RAN for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for RAN (see all 15)
    PGOHUM00000242805 PGOHUM00000258697 PGOHUM00000258698 PGOHUM00000259570 PGOHUM00000237958


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAN (see all 183)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447126931,2
    --131354671(+) GTTCCA/GTCACA 1 -- us2k10--------
    rs113466641,2
    C--131354743(+) CAATT-/AAAAAA 1 -- us2k1 tfbs30--------
    rs1384490591,2
    --131354748(+) AAAAAA/CAACAA 1 -- us2k10--------
    rs2000753411,2
    --131354751(+) AAAAA-/CAACAA 1 -- us2k10--------
    rs2001590051,2
    --131354784(+) TATGC-/TTTTG 
            
    TTTTA
    1 -- us2k10--------
    rs1927985261,2
    --131354948(+) ATTGCA/CCATTG 1 -- us2k10--------
    rs752296801,2
    C,F--131355024(+) GTGGCC/TTAGAC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs561095431,2
    C--131355065(+) TTTCTC/TAACAC 1 -- us2k16Minor allele frequency- T:0.19WA CSA NA EA 363
    rs1832390271,2
    --131355210(+) CCGGGC/GTCACA 1 -- us2k10--------
    rs783890741,2
    C--131355412(+) CTGCAG/AGGAGG 1 -- us2k14Minor allele frequency- A:0.11NA WA EA 360

    HapMap Linkage Disequilibrium report for RAN (131356424 - 131362223 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAN: --
    Human Gene Mutation Database (HGMD): RAN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAN
    DNA2.0 Custom Variant and Variant Library Synthesis for RAN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601179    OMIM disorders: --

    Selected diseases for RAN (see all 60):    About MalaCards
    kennedy's disease    spinal-bulbar muscular atrophy    muscular atrophy    chronic myelomonocytic leukemia
    diamond-blackfan anemia    papillary carcinoma    progeria    pleomorphic adenoma
    acquired immunodeficiency syndrome    myeloproliferative disorder    clear cell renal cell carcinoma    endocarditis
    myelodysplastic syndromes    teratocarcinoma    human t-cell leukemia virus type 1    neurofibromatosis
    panic disorder    lymphoblastic leukemia    vaccinia    renal cell carcinoma


    RAN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RAN gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thyroid carcinoma anaplastic 42.9 1 16264365 (1)
    tumors 41.4 54 20515613 (2), 17483353 (2), 8025268 (1), 9798676 (1) (see all 43)
    cancer 38.6 32 18563304 (2), 14585179 (1), 15475460 (1), 16757353 (1) (see all 23)
    neoplastic transformation 34.2 1 9765202 (1)
    thyroid papillary carcinoma 31.2 2 17943694 (1), 15761501 (1)
    pancreatic cancer 21.5 2 17088984 (1), 19639215 (1)
    myelodysplastic syndromes 20.9 2 8431911 (1), 15345287 (1)
    colon cancer 8.7 1 10357561 (1)
    melanoma 7.09 5 2278957 (1), 16627974 (1), 1643431 (1), 8062279 (1)
    necrosis 3.56 1 8062279 (1)

    Genetic Association Database (GAD): RAN
    Human Genome Epidemiology (HuGE) Navigator: RAN (49 documents)
    Tumor Gene Database (TGDB): RAN

    Export disorders for RAN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAN gene, integrated from 10 sources (see all 473):
    (articles sorted by number of sources associating them with RAN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. (PubMed id 8421051)1, 2, 3 Ren M.... Rush M.G. (J. Cell Biol. 1993)
    2. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. (PubMed id 10078529)1, 2, 9 Vetter I.R.... Wittinghofer A. (Nature 1999)
    3. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PubMed id 18617507)1, 2, 9 Sanz-Garcia M.... Lazo P.A. (Mol. Cell. Proteomics 2008)
    4. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PubMed id 9837918)1, 2, 9 Askjaer P.... Kjems J. (J. Biol. Chem. 1998)
    5. Crystal structure of the nuclear Ras-related protein Ran in its GDP- bound form. (PubMed id 7885480)1, 2, 9 Scheffzek K.... Wittinghofer A. (Nature 1995)
    6. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PubMed id 20819778)1, 4 Zhang X....Wu X. (Carcinogenesis 2010)
    7. Association of a common AGO1 variant with lung cancer risk: a two-stage case-control study. (PubMed id 20721975)1, 4 Kim J.S....Park J.Y. (Mol. Carcinog. 2010)
    8. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PubMed id 20732906)1, 4 Lin J....Wu X. (Carcinogenesis 2010)
    9. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PubMed id 19851984)1, 4 Clague J....Wu X. (Mol. Carcinog. 2010)
    10. The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle. (PubMed id 19753112)1, 2 Medendorp K.... van Kessel A.G. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5901 HGNC: 9846 AceView: RAN Ensembl:ENSG00000132341 euGenes: HUgn5901
    ECgene: RAN Kegg: 5901 H-InvDB: RAN

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAN gene:
    Search GeneIP for patents involving RAN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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