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Aliases for RAN Gene

Aliases for RAN Gene

  • RAN, Member RAS Oncogene Family 2 3 5
  • Androgen Receptor-Associated Protein 24 3 4
  • Ras-Related Nuclear Protein 3 4
  • Ras-Like Protein TC4 3 4
  • GTPase Ran 3 4
  • ARA24 3 4
  • Guanosine Triphosphatase Ran 3
  • Member RAS Oncogene Family 3
  • OK/SW-Cl.81 3
  • RanGTPase 3
  • Gsp1 3
  • TC4 3

External Ids for RAN Gene

Previous GeneCards Identifiers for RAN Gene

  • GC12P129785
  • GC12P131119
  • GC12P030224
  • GC12P129709
  • GC12P129881
  • GC12P131356
  • GC12P128338

Summaries for RAN Gene

Entrez Gene Summary for RAN Gene

  • RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAN Gene

RAN (RAN, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAN include Teratocarcinoma and Goodpasture Syndrome. Among its related pathways are HTLV-I infection and Androgen receptor signaling pathway. GO annotations related to this gene include poly(A) RNA binding and GTP binding. An important paralog of this gene is RABL2A.

UniProtKB/Swiss-Prot for RAN Gene

  • GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.

  • Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Gene Wiki entry for RAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAN Gene

Genomics for RAN Gene

Regulatory Elements for RAN Gene

Enhancers for RAN Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAN on UCSC Golden Path with GeneCards custom track

Promoters for RAN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAN on UCSC Golden Path with GeneCards custom track

Genomic Location for RAN Gene

Chromosome:
12
Start:
130,871,879 bp from pter
End:
130,877,678 bp from pter
Size:
5,800 bases
Orientation:
Plus strand

Genomic View for RAN Gene

Genes around RAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAN Gene

Proteins for RAN Gene

  • Protein details for RAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62826-RAN_HUMAN
    Recommended name:
    GTP-binding nuclear protein Ran
    Protein Accession:
    P62826
    Secondary Accessions:
    • A8K3Z8
    • P17080
    • P28746
    • P28747
    • Q6IPB2
    • Q86V08
    • Q8NI90
    • Q9CSP3
    • Q9CWI7
    • Q9CZA2
    • Q9UDJ5
    • Q9UEU9

    Protein attributes for RAN Gene

    Size:
    216 amino acids
    Molecular mass:
    24423 Da
    Quaternary structure:
    • Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and isoform 2 of VRK2. Interacts with NEMP1 and KPNB1 (By similarity).
    SequenceCaution:
    • Sequence=BAB93486.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAN Gene

neXtProt entry for RAN Gene

Proteomics data for RAN Gene at MOPED

Post-translational modifications for RAN Gene

  • Ubiquitination at Lys 23, Lys 38, Lys 60, Lys 99, Lys 123, Lys 127, and Lys 141
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAN Gene

Domains & Families for RAN Gene

Gene Families for RAN Gene

Protein Domains for RAN Gene

Graphical View of Domain Structure for InterPro Entry

P62826

UniProtKB/Swiss-Prot:

RAN_HUMAN :
  • Belongs to the small GTPase superfamily. Ran family.
Family:
  • Belongs to the small GTPase superfamily. Ran family.
genes like me logo Genes that share domains with RAN: view

Function for RAN Gene

Molecular function for RAN Gene

GENATLAS Biochemistry:
Ras related GTPase component of the nuclear protein complex (NPC) mediating nucleocytoplasmic transport of proteins and ribonucleoproteins,expressed in a human teratocarcinoma cell line and in a range of human cell types
UniProtKB/Swiss-Prot Function:
GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
UniProtKB/Swiss-Prot Function:
Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.

Gene Ontology (GO) - Molecular Function for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 1961752
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0050681 androgen receptor binding NAS 15572661
GO:0061676 importin-alpha family protein binding IEA --
genes like me logo Genes that share ontologies with RAN: view
genes like me logo Genes that share phenotypes with RAN: view

Animal Model Products

miRNA for RAN Gene

miRTarBase miRNAs that target RAN

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAN Gene

Localization for RAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAN Gene

Nucleus. Cytoplasm. Melanosome. Nucleus envelope. Note=Predominantly nuclear during interphase. Becomes dispersed throughout the cytoplasm during mitosis. Colocalizes with NEMP1 at the nuclear envelope (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250 UniProtKB:P62827}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAN Gene COMPARTMENTS Subcellular localization image for RAN gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005737 cytoplasm IDA 1961752
GO:0030496 midbody IDA 19166812
GO:0042470 melanosome IEA --
GO:0042565 RNA nuclear export complex IDA 14681208
genes like me logo Genes that share ontologies with RAN: view

Pathways & Interactions for RAN Gene

genes like me logo Genes that share pathways with RAN: view

SIGNOR curated interactions for RAN Gene

Is activated by:
Other effect:

Gene Ontology (GO) - Biological Process for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006606 protein import into nucleus IEA --
GO:0006611 protein export from nucleus IDA 16449645
genes like me logo Genes that share ontologies with RAN: view

Drugs & Compounds for RAN Gene

(13) Drugs for RAN Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0
Guanosine triphosphate Experimental Pharma 0

(11) Additional Compounds for RAN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAN: view

Transcripts for RAN Gene

Unigene Clusters for RAN Gene

RAN, member RAS oncogene family:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3: -
SP4: - - - - - - -
SP5:
SP6:

Relevant External Links for RAN Gene

GeneLoc Exon Structure for
RAN
ECgene alternative splicing isoforms for
RAN

Expression for RAN Gene

mRNA expression in normal human tissues for RAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAN Gene



SOURCE GeneReport for Unigene cluster for RAN Gene Hs.10842

mRNA Expression by UniProt/SwissProt for RAN Gene

P62826-RAN_HUMAN
Tissue specificity: Expressed in a variety of tissues.
genes like me logo Genes that share expression patterns with RAN: view

Protein tissue co-expression partners for RAN Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for RAN Gene

Orthologs for RAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAN 35
  • 92.75 (n)
  • 100 (a)
RAN 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAN 35
  • 87.5 (n)
  • 100 (a)
RAN 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ran 35
  • 89.66 (n)
  • 100 (a)
Ran 16
1700009N14Rik 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAN 35
  • 99.85 (n)
  • 100 (a)
RAN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ran 35
  • 89.2 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAN 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAN 35
  • 88.58 (n)
  • 98.61 (a)
RAN 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAN 36
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ran 35
  • 84.1 (n)
  • 97.69 (a)
Str.6581 35
African clawed frog
(Xenopus laevis)
Amphibia ran-1-prov 35
zebrafish
(Danio rerio)
Actinopterygii ran 35
  • 79.75 (n)
  • 94.86 (a)
ran 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ran-like 37
  • 60 (a)
ran 35
  • 71.91 (n)
  • 87.04 (a)
ran-like 36
  • 59 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007699 35
  • 75.73 (n)
  • 91.26 (a)
worm
(Caenorhabditis elegans)
Secernentea ran-1 37
  • 93 (a)
ran-1 35
  • 73.95 (n)
  • 89.81 (a)
ran-1 36
  • 87 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR294C 35
  • 71.57 (n)
  • 83.33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05126g 35
  • 72.06 (n)
  • 83.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GSP1 35
  • 70.75 (n)
  • 83.02 (a)
GSP1 36
  • 80 (a)
OneToMany
GSP2 36
  • 79 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAN2 35
  • 71.22 (n)
  • 78.05 (a)
rice
(Oryza sativa)
Liliopsida Os01g0611100 35
  • 68.93 (n)
  • 77.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09269 35
  • 68.46 (n)
  • 80 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spi1 35
  • 69.03 (n)
  • 81.6 (a)
Species with no ortholog for RAN:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAN Gene

ENSEMBL:
Gene Tree for RAN (if available)
TreeFam:
Gene Tree for RAN (if available)

Paralogs for RAN Gene

Paralogs for RAN Gene

genes like me logo Genes that share paralogs with RAN: view

Variants for RAN Gene

Sequence variations from dbSNP and Humsavar for RAN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_051900 -
rs14035 -- 130,876,696(+) AGAAC(C/T)TCAAA utr-variant-3-prime
rs15220 -- 130,876,076(+) GGGCT(C/T)CGGAG utr-variant-3-prime
rs7135682 -- 130,874,129(+) CAGAC(A/G)TGAGC intron-variant
rs7136324 -- 130,874,007(+) TATGC(C/T)TGACT intron-variant

Variation tolerance for RAN Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAN Gene

Human Gene Mutation Database (HGMD)
RAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAN Gene

Disorders for RAN Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAN Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
teratocarcinoma
  • mixed embryonal carcinoma and teratoma
goodpasture syndrome
  • anti-glomerular basement membrane disease
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search RAN in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAN

Genetic Association Database (GAD)
RAN
Human Genome Epidemiology (HuGE) Navigator
RAN
Tumor Gene Database (TGDB):
RAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAN
genes like me logo Genes that share disorders with RAN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAN Gene

Publications for RAN Gene

  1. Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. (PMID: 8421051) Ren M. … Rush M.G. (J. Cell Biol. 1993) 2 3 4 67
  2. Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation. (PMID: 20028979) Ly T.K. … Wilson K.F. (J. Biol. Chem. 2010) 3 23
  3. RAN GTPase is a RASSF1A effector involved in controlling microtubule organization. (PMID: 19559616) Dallol A. … Latif F. (Curr. Biol. 2009) 3 23
  4. Dynamic localisation of Ran GTPase during the cell cycle. (PMID: 19765287) Hutchins J.R. … Clarke P.R. (BMC Cell Biol. 2009) 3 23
  5. High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. (PMID: 18241036) Abe H. … Yoshida K. (Int. J. Cancer 2008) 3 23

Products for RAN Gene

  • Addgene plasmids for RAN

Sources for RAN Gene

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