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Aliases for RAN Gene

Aliases for RAN Gene

  • RAN, Member RAS Oncogene Family 2 3
  • ARA24 3 4 6
  • Androgen Receptor-Associated Protein 24 3 4
  • Ras-Related Nuclear Protein 3 4
  • Ras-Like Protein TC4 3 4
  • GTPase Ran 3 4
  • GTP-Binding Nuclear Protein Ran 3
  • Guanosine Triphosphatase Ran 3
  • Member RAS Oncogene Family 3
  • OK/SW-Cl.81 3
  • RanGTPase 3
  • Gsp1 3
  • TC4 3

External Ids for RAN Gene

Previous GeneCards Identifiers for RAN Gene

  • GC12P129785
  • GC12P131119
  • GC12P030224
  • GC12P129709
  • GC12P129881
  • GC12P131356
  • GC12P128338

Summaries for RAN Gene

Entrez Gene Summary for RAN Gene

  • RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAN Gene

RAN (RAN, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAN include hutchinson-gilford progeria and muscular atrophy. Among its related pathways are Disease and TGF-Beta Pathway. GO annotations related to this gene include GTP binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for RAN Gene

  • GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.

  • Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases

Gene Wiki entry for RAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAN Gene

Genomics for RAN Gene

Regulatory Elements for RAN Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAN Gene

Start:
130,871,879 bp from pter
End:
130,877,678 bp from pter
Size:
5,800 bases
Orientation:
Plus strand

Genomic View for RAN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAN Gene

Proteins for RAN Gene

  • Protein details for RAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62826-RAN_HUMAN
    Recommended name:
    GTP-binding nuclear protein Ran
    Protein Accession:
    P62826
    Secondary Accessions:
    • A8K3Z8
    • P17080
    • P28746
    • P28747
    • Q6IPB2
    • Q86V08
    • Q8NI90
    • Q9CSP3
    • Q9CWI7
    • Q9CZA2
    • Q9UDJ5
    • Q9UEU9

    Protein attributes for RAN Gene

    Size:
    216 amino acids
    Molecular mass:
    24423 Da
    Quaternary structure:
    • Monomer. Also forms a complex with CHC1 and interacts with the AR N-terminal poly-Gln region. The interaction with AR is inversely correlated with the poly-Gln length. Part of a complex consisting of RANBP9, Ran, DYRK1B and COPS5. Found in a nuclear export complex with RANBP3 and XPO1. Component of a nuclear export receptor complex composed of KPNB1, Ran, SNUPN and XPO1. Found in a trimeric export complex with SNUPN, Ran and XPO1. Interacts with RANBP10. In case of HIV-1 infection, found in a complex with HIV-1 Rev, RNAs containing a Rev response element (RRE) and XPO1. Found in a complex with HTLV-1 Rex, RANBP3 and XPO1. Interacts in its GTP-bound form with BIRC5/survivin at S and M phases of the cell cycle. Interacts with TERT; the interaction requires hydrogen peroxide-mediated phosphorylation of TERT and transports TERT to the nucleus. Interacts with MAD2L2. Interacts with RANBP10 (By similarity). Interacts with VRK1 and VRK3. Interacts with isoform 1 and isoform 2 of VRK2.
    SequenceCaution:
    • Sequence=BAB93486.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAN Gene

neXtProt entry for RAN Gene

Proteomics data for RAN Gene at MOPED

Post-translational modifications for RAN Gene

  • Ubiquitination at Lys23, Lys38, Lys60, Lys99, Lys123, Lys127, Lys134, Lys141, Lys142, Lys152, and Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for RAN Gene

No data available for DME Specific Peptides for RAN Gene

Domains for RAN Gene

Protein Domains for RAN Gene

Graphical View of Domain Structure for InterPro Entry

P62826

UniProtKB/Swiss-Prot:

RAN_HUMAN :
  • P62826
Family:
  • Belongs to the small GTPase superfamily. Ran family.
genes like me logo Genes that share domains with RAN: view

No data available for Gene Families for RAN Gene

Function for RAN Gene

Molecular function for RAN Gene

GENATLAS Biochemistry: Ras related GTPase component of the nuclear protein complex (NPC) mediating nucleocytoplasmic transport of proteins and ribonucleoproteins,expressed in a human teratocarcinoma cell line and in a range of human cell types
UniProtKB/Swiss-Prot Function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
UniProtKB/Swiss-Prot Function: Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases

Gene Ontology (GO) - Molecular Function for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 1961752
GO:0003713 transcription coactivator activity NAS 15572661
GO:0003924 GTPase activity TAS 10400640
GO:0005515 protein binding IPI 10353245
GO:0005525 GTP binding IMP 18938132
genes like me logo Genes that share ontologies with RAN: view
genes like me logo Genes that share phenotypes with RAN: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAN Gene

Localization for RAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAN Gene

Nucleus. Cytoplasm. Melanosome. Note=Predominantly nuclear during interphase (By similarity). Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAN Gene COMPARTMENTS Subcellular localization image for RAN gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 colocalizes_with chromatin IDA 1961752
GO:0005622 intracellular --
GO:0005634 nucleus IDA 21630459
GO:0005643 nuclear pore NAS 8421051
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RAN: view

Pathways for RAN Gene

genes like me logo Genes that share pathways with RAN: view

Gene Ontology (GO) - Biological Process for RAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000055 ribosomal large subunit export from nucleus IMP 12773398
GO:0000056 ribosomal small subunit export from nucleus IMP 12773398
GO:0000060 protein import into nucleus, translocation IMP 18266911
GO:0006184 obsolete GTP catabolic process --
GO:0006259 DNA metabolic process TAS 8421051
genes like me logo Genes that share ontologies with RAN: view

Compounds for RAN Gene

(1) HMDB Compounds for RAN Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(1) Drugbank Compounds for RAN Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target

(22) Novoseek inferred chemical compound relationships for RAN Gene

Compound -log(P) Hits PubMed IDs
gtp 79.5 73
leptomycin b 70.7 4
gdp 70.6 24
xanthosine 5-triphosphate 69 1
gppnhp 53.1 2
genes like me logo Genes that share compounds with RAN: view

Transcripts for RAN Gene

Unigene Clusters for RAN Gene

RAN, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAN

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RAN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAN Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2: - -
SP3: -
SP4: - - - - - - -
SP5:
SP6:

Relevant External Links for RAN Gene

GeneLoc Exon Structure for
RAN
ECgene alternative splicing isoforms for
RAN

Expression for RAN Gene

mRNA expression in normal human tissues for RAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAN Gene

SOURCE GeneReport for Unigene cluster for RAN Gene Hs.10842

mRNA Expression by UniProt/SwissProt for RAN Gene

P62826-RAN_HUMAN
Tissue specificity: Expressed in a variety of tissues.
genes like me logo Genes that share expressions with RAN: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAN Gene

Orthologs for RAN Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAN 35
  • 99.85 (n)
  • 100 (a)
RAN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAN 35
  • 92.75 (n)
  • 100 (a)
RAN 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAN 35
  • 87.5 (n)
  • 100 (a)
RAN 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700009N14Rik 36
  • 93 (a)
OneToOne
Ran 35
  • 89.66 (n)
  • 100 (a)
Ran 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RAN 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ran 35
  • 89.2 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves RAN 35
  • 88.58 (n)
  • 98.61 (a)
RAN 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAN 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ran-1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ran 35
  • 84.1 (n)
  • 97.69 (a)
Str.6581 35
zebrafish
(Danio rerio)
Actinopterygii ran 35
  • 79.75 (n)
  • 94.86 (a)
ran 36
  • 95 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007699 35
  • 75.73 (n)
  • 91.26 (a)
fruit fly
(Drosophila melanogaster)
Insecta ran 35
  • 71.91 (n)
  • 87.04 (a)
ran-like 36
  • 59 (a)
OneToOne
ran-like 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea ran-1 35
  • 73.95 (n)
  • 89.81 (a)
ran-1 36
  • 87 (a)
OneToOne
ran-1 37
  • 93 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR294C 35
  • 71.57 (n)
  • 83.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GSP1 35
  • 70.75 (n)
  • 83.02 (a)
GSP1 36
  • 80 (a)
OneToMany
GSP2 36
  • 79 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05126g 35
  • 72.06 (n)
  • 83.33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAN2 35
  • 71.22 (n)
  • 78.05 (a)
rice
(Oryza sativa)
Liliopsida Os01g0611100 35
  • 68.93 (n)
  • 77.18 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09269 35
  • 68.46 (n)
  • 80 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes spi1 35
  • 69.03 (n)
  • 81.6 (a)
Species with no ortholog for RAN:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAN Gene

ENSEMBL:
Gene Tree for RAN (if available)
TreeFam:
Gene Tree for RAN (if available)

Paralogs for RAN Gene

genes like me logo Genes that share paralogs with RAN: view

No data available for Paralogs for RAN Gene

Variants for RAN Gene

Sequence variations from dbSNP and Humsavar for RAN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14035 -- 130,876,696(+) AGAAC(C/T)TCAAA utr-variant-3-prime
rs15220 -- 130,876,076(+) GGGCT(C/T)CGGAG utr-variant-3-prime
rs1045515 -- 130,876,192(+) ACATC(A/C)CAATA utr-variant-3-prime
rs1127636 -- 130,872,117(+) AGACG(C/T)TTCTG utr-variant-5-prime
rs1802281 -- 130,876,617(+) AAATG(A/T)GGTTT utr-variant-3-prime

Relevant External Links for RAN Gene

HapMap Linkage Disequilibrium report
RAN
Human Gene Mutation Database (HGMD)
RAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAN Gene

Disorders for RAN Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for RAN Gene including...

Search for RAN Gene in MalaCards »

(29) Novoseek inferred disease relationships for RAN Gene

Disease -log(P) Hits PubMed IDs
thyroid carcinoma anaplastic 42.9 1
tumors 41.4 45
cancer 38.6 24
neoplastic transformation 34.2 1
thyroid papillary carcinoma 31.2 2

Relevant External Links for RAN

Genetic Association Database (GAD)
RAN
Human Genome Epidemiology (HuGE) Navigator
RAN
Tumor Gene Database (TGDB):
RAN
genes like me logo Genes that share disorders with RAN: view

No data available for UniProtKB/Swiss-Prot for RAN Gene

Publications for RAN Gene

  1. Crystal structure of the nuclear Ras-related protein Ran in its GDP- bound form. (PMID: 7885480) Scheffzek K. … Wittinghofer A. (Nature 1995) 3 4 23
  2. The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP. (PMID: 9837918) Askjaer P. … Kjems J. (J. Biol. Chem. 1998) 3 4 23
  3. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. (PMID: 10078529) Vetter I.R. … Wittinghofer A. (Nature 1999) 3 4 23
  4. Proteomics identification of nuclear Ran GTPase as an inhibitor of human VRK1 and VRK2 (vaccinia-related kinase) activities. (PMID: 18617507) Sanz-Garcia M. … Lazo P.A. (Mol. Cell. Proteomics 2008) 3 4 23
  5. Ran/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis. (PMID: 8421051) Ren M. … Rush M.G. (J. Cell Biol. 1993) 2 3 4

Products for RAN Gene

  • Addgene plasmids for RAN

Sources for RAN Gene

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