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Aliases for RAMP3 Gene

Aliases for RAMP3 Gene

  • Receptor (G Protein-Coupled) Activity Modifying Protein 3 2 3
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 4
  • Receptor (Calcitonin) Activity Modifying Protein 3 2
  • Receptor Activity Modifying Protein 3 2
  • CRLR Activity-Modifying Protein 3 4

External Ids for RAMP3 Gene

Previous GeneCards Identifiers for RAMP3 Gene

  • GC07P044843
  • GC07P044938
  • GC07P044970

Summaries for RAMP3 Gene

Entrez Gene Summary for RAMP3 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP3 Gene

RAMP3 (Receptor (G Protein-Coupled) Activity Modifying Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP3 Gene

  • Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP3 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP3 Gene

Genomics for RAMP3 Gene

Regulatory Elements for RAMP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAMP3 Gene

Start:
45,157,768 bp from pter
End:
45,186,302 bp from pter
Size:
28,535 bases
Orientation:
Plus strand

Genomic View for RAMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP3 Gene

Proteins for RAMP3 Gene

  • Protein details for RAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60896-RAMP3_HUMAN
    Recommended name:
    Receptor activity-modifying protein 3
    Protein Accession:
    O60896
    Secondary Accessions:
    • Q7Z2Y1

    Protein attributes for RAMP3 Gene

    Size:
    148 amino acids
    Molecular mass:
    16518 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

neXtProt entry for RAMP3 Gene

Proteomics data for RAMP3 Gene at MOPED

Post-translational modifications for RAMP3 Gene

  • Glycosylation at Asn29, Asn58, Asn71, and Asn103

Other Protein References for RAMP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RAMP3 Gene

Domains for RAMP3 Gene

Gene Families for RAMP3 Gene

HGNC:
  • RAMP :Receptor (G protein-coupled) activity modifying proteins

Protein Domains for RAMP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60896

UniProtKB/Swiss-Prot:

RAMP3_HUMAN :
  • O60896
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP3: view

Function for RAMP3 Gene

Molecular function for RAMP3 Gene

UniProtKB/Swiss-Prot Function: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0005515 protein binding IPI 15613468
GO:0008565 protein transporter activity IDA 10882736
GO:0015026 coreceptor activity IEA --
genes like me logo Genes that share ontologies with RAMP3: view

Phenotypes for RAMP3 Gene

MGI mutant phenotypes for RAMP3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RAMP3: view

Animal Models for RAMP3 Gene

MGI Knock Outs for RAMP3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RAMP3 Gene

Localization for RAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP3 Gene

Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAMP3 Gene COMPARTMENTS Subcellular localization image for RAMP3 gene
Compartment Confidence
lysosome 4
plasma membrane 4
vacuole 4
extracellular 3

Gene Ontology (GO) - Cellular Components for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 23674134
GO:0005764 colocalizes_with lysosome IDA 15613468
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0009986 cell surface IDA 10882736
genes like me logo Genes that share ontologies with RAMP3: view

Pathways for RAMP3 Gene

genes like me logo Genes that share pathways with RAMP3: view

Pathways by source for RAMP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IDA 15613468
GO:0006816 calcium ion transport IDA 10882736
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
genes like me logo Genes that share ontologies with RAMP3: view

Compounds for RAMP3 Gene

(5) Tocris Compounds for RAMP3 Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(1) Drugbank Compounds for RAMP3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Pramlintide
151126-32-8 target agonist

(3) Novoseek inferred chemical compound relationships for RAMP3 Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 88.1 1
adenylate 27.4 1
nitric oxide 0 1
genes like me logo Genes that share compounds with RAMP3: view

Transcripts for RAMP3 Gene

mRNA/cDNA for RAMP3 Gene

Unigene Clusters for RAMP3 Gene

Receptor (G protein-coupled) activity modifying protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for RAMP3 Gene

GeneLoc Exon Structure for
RAMP3
ECgene alternative splicing isoforms for
RAMP3

Expression for RAMP3 Gene

mRNA expression in normal human tissues for RAMP3 Gene

mRNA differential expression in normal tissues according to GTEx for RAMP3 Gene

This gene is overexpressed in Lung (4.4).

SOURCE GeneReport for Unigene cluster for RAMP3 Gene Hs.25691

mRNA Expression by UniProt/SwissProt for RAMP3 Gene

O60896-RAMP3_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.
genes like me logo Genes that share expressions with RAMP3: view

In Situ Assay Products

No data available for Protein expression for RAMP3 Gene

Orthologs for RAMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAMP3 35
  • 99.1 (n)
  • 97.97 (a)
RAMP3 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAMP3 35
  • 79.5 (n)
  • 71.62 (a)
RAMP3 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855938 35
  • 83.94 (n)
  • 83.21 (a)
RAMP3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ramp3 35
  • 84.87 (n)
  • 86.15 (a)
Ramp3 16
Ramp3 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAMP3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAMP3 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp3 35
  • 82.31 (n)
  • 86.92 (a)
chicken
(Gallus gallus)
Aves RAMP3 35
  • 66.39 (n)
  • 70.83 (a)
RAMP3 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAMP3 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp3 35
  • 56.8 (n)
  • 56.8 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-334d15.2 36
  • 22 (a)
ManyToMany
Species with no ortholog for RAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP3 Gene

ENSEMBL:
Gene Tree for RAMP3 (if available)
TreeFam:
Gene Tree for RAMP3 (if available)

Paralogs for RAMP3 Gene

Paralogs for RAMP3 Gene

Selected SIMAP similar genes for RAMP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP3: view

Variants for RAMP3 Gene

Sequence variations from dbSNP and Humsavar for RAMP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15995 -- 45,183,945(+) GGTGG(A/G)AAGAC utr-variant-3-prime
rs740087 -- 45,178,573(+) AACTG(C/T)TTGCT intron-variant
rs929329 -- 45,163,120(-) ACCAA(G/T)AATTC intron-variant
rs929330 -- 45,163,031(-) TCAGA(C/T)GTGCA intron-variant
rs1046290 -- 45,183,479(+) GGAGA(G/T)CGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAMP3 Gene

Variant ID Type Subtype PubMed ID
nsv830986 CNV Loss 17160897
nsv516731 CNV Loss 19592680
esv28566 CNV Gain 19812545

Relevant External Links for RAMP3 Gene

HapMap Linkage Disequilibrium report
RAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP3 Gene

Disorders for RAMP3 Gene

(2) Novoseek inferred disease relationships for RAMP3 Gene

Disease -log(P) Hits PubMed IDs
cardiac hypertrophy 18.1 1
heart failure 7.66 1

Relevant External Links for RAMP3

Genetic Association Database (GAD)
RAMP3
Human Genome Epidemiology (HuGE) Navigator
RAMP3
genes like me logo Genes that share disorders with RAMP3: view

No data available for UniProtKB/Swiss-Prot for RAMP3 Gene

Publications for RAMP3 Gene

  1. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  2. Genomic structure and chromosome mapping of human and mouse RAMP genes. (PMID: 11060459) Derst C. … Daut J. (Cytogenet. Cell Genet. 2000) 3 23
  3. The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors. (PMID: 11591721) Kuwasako K. … Eto T. (J. Biol. Chem. 2001) 3 23
  4. Novel receptor partners and function of receptor activity-modifying proteins. (PMID: 12446722) Christopoulos A. … Sexton P.M. (J. Biol. Chem. 2003) 3 23
  5. N-Glycosylation and conserved cysteine residues in RAMP3 play a critical role for the functional expression of CRLR/RAMP3 adrenomedullin receptor. (PMID: 12939163) Flahaut M. … Firsov D. (Biochemistry 2003) 3 23

Products for RAMP3 Gene

Sources for RAMP3 Gene

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