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Aliases for RAMP3 Gene

Aliases for RAMP3 Gene

  • Receptor (G Protein-Coupled) Activity Modifying Protein 3 2 3 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 4
  • Receptor (Calcitonin) Activity Modifying Protein 3 2
  • Receptor Activity Modifying Protein 3 2
  • CRLR Activity-Modifying Protein 3 4

External Ids for RAMP3 Gene

Previous GeneCards Identifiers for RAMP3 Gene

  • GC07P044843
  • GC07P044938
  • GC07P044970

Summaries for RAMP3 Gene

Entrez Gene Summary for RAMP3 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP3 Gene

RAMP3 (Receptor (G Protein-Coupled) Activity Modifying Protein 3) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP3 Gene

  • Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP3 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP3 Gene

Genomics for RAMP3 Gene

Regulatory Elements for RAMP3 Gene

Enhancers for RAMP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAMP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAMP3 Gene

Chromosome:
7
Start:
45,157,768 bp from pter
End:
45,186,302 bp from pter
Size:
28,535 bases
Orientation:
Plus strand

Genomic View for RAMP3 Gene

Genes around RAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP3 Gene

Proteins for RAMP3 Gene

  • Protein details for RAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60896-RAMP3_HUMAN
    Recommended name:
    Receptor activity-modifying protein 3
    Protein Accession:
    O60896
    Secondary Accessions:
    • Q7Z2Y1

    Protein attributes for RAMP3 Gene

    Size:
    148 amino acids
    Molecular mass:
    16518 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

neXtProt entry for RAMP3 Gene

Proteomics data for RAMP3 Gene at MOPED

Post-translational modifications for RAMP3 Gene

  • Glycosylation at Asn 29, Asn 58, Asn 71, and Asn 103

Other Protein References for RAMP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAMP3 Gene

Domains & Families for RAMP3 Gene

Protein Domains for RAMP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60896

UniProtKB/Swiss-Prot:

RAMP3_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP3: view

Function for RAMP3 Gene

Molecular function for RAMP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
genes like me logo Genes that share phenotypes with RAMP3: view

Animal Models for RAMP3 Gene

MGI Knock Outs for RAMP3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP3 Gene

Localization for RAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP3 Gene

Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAMP3 Gene COMPARTMENTS Subcellular localization image for RAMP3 gene
Compartment Confidence
plasma membrane 5
lysosome 4
vacuole 4
extracellular 3

Gene Ontology (GO) - Cellular Components for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 colocalizes_with lysosome IDA 15613468
GO:0005887 integral component of plasma membrane TAS 9620797
genes like me logo Genes that share ontologies with RAMP3: view

Pathways & Interactions for RAMP3 Gene

genes like me logo Genes that share pathways with RAMP3: view

Gene Ontology (GO) - Biological Process for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IDA 10882736
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA --
GO:0072659 protein localization to plasma membrane IDA 10882736
GO:0090004 positive regulation of establishment of protein localization to plasma membrane IDA 23674134
genes like me logo Genes that share ontologies with RAMP3: view

No data available for SIGNOR curated interactions for RAMP3 Gene

Drugs & Compounds for RAMP3 Gene

(2) Drugs for RAMP3 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43

(7) Additional Compounds for RAMP3 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
PHM 27 (human)
118025-43-7
SUN-B 8155
345893-91-6

(5) Tocris Compounds for RAMP3 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP3: view

Transcripts for RAMP3 Gene

Unigene Clusters for RAMP3 Gene

Receptor (G protein-coupled) activity modifying protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for RAMP3 Gene

GeneLoc Exon Structure for
RAMP3
ECgene alternative splicing isoforms for
RAMP3

Expression for RAMP3 Gene

mRNA expression in normal human tissues for RAMP3 Gene

mRNA differential expression in normal tissues according to GTEx for RAMP3 Gene

This gene is overexpressed in Lung (x4.4).

SOURCE GeneReport for Unigene cluster for RAMP3 Gene Hs.25691

mRNA Expression by UniProt/SwissProt for RAMP3 Gene

O60896-RAMP3_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.
genes like me logo Genes that share expression patterns with RAMP3: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RAMP3 Gene

Orthologs for RAMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAMP3 35
  • 79.5 (n)
  • 71.62 (a)
RAMP3 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100855938 35
  • 83.94 (n)
  • 83.21 (a)
RAMP3 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ramp3 35
  • 84.87 (n)
  • 86.15 (a)
Ramp3 16
Ramp3 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAMP3 35
  • 99.1 (n)
  • 97.97 (a)
RAMP3 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp3 35
  • 82.31 (n)
  • 86.92 (a)
oppossum
(Monodelphis domestica)
Mammalia RAMP3 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAMP3 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAMP3 35
  • 66.39 (n)
  • 70.83 (a)
RAMP3 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAMP3 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp3 35
  • 56.8 (n)
  • 56.8 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-334d15.2 36
  • 22 (a)
ManyToMany
Species with no ortholog for RAMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP3 Gene

ENSEMBL:
Gene Tree for RAMP3 (if available)
TreeFam:
Gene Tree for RAMP3 (if available)

Paralogs for RAMP3 Gene

Paralogs for RAMP3 Gene

(2) SIMAP similar genes for RAMP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP3: view

Variants for RAMP3 Gene

Sequence variations from dbSNP and Humsavar for RAMP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2074654 - 45,177,416(-) GCACC(A/G)CTTCC reference, missense
rs10272187 - 45,177,327(+) AGCAG(A/G)CGGCT reference, missense
rs11550711 - 45,177,347(+) CAGGC(A/C/G)TGTTG reference, missense
rs929329 -- 45,163,120(-) ACCAA(G/T)AATTC intron-variant
rs929330 -- 45,163,031(-) TCAGA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP3 Gene

Variant ID Type Subtype PubMed ID
nsv830986 CNV Loss 17160897
nsv516731 CNV Loss 19592680
esv28566 CNV Gain 19812545

Variation tolerance for RAMP3 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAMP3 Gene

Disorders for RAMP3 Gene

Relevant External Links for RAMP3

Genetic Association Database (GAD)
RAMP3
Human Genome Epidemiology (HuGE) Navigator
RAMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAMP3

No disorders were found for RAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAMP3 Gene

Publications for RAMP3 Gene

  1. G-protein-coupled receptor 30 interacts with receptor activity- modifying protein 3 and confers sex-dependent cardioprotection. (PMID: 23674134) Lenhart P.M. … Caron K.M. (J. Mol. Endocrinol. 2013) 3 4 67
  2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  3. Functional characterization of two human receptor activity-modifying protein 3 variants. (PMID: 20034525) Bailey R.J. … Hay D.L. (Peptides 2010) 3 23
  4. Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. (PMID: 19886671) Harikumar K.G. … Miller L.J. (Biochemistry 2009) 3 23
  5. Receptor activity-modifying protein (RAMP) isoform-specific regulation of adrenomedullin receptor trafficking by NHERF-1. (PMID: 15805108) Bomberger J.M. … Parameswaran N. (J. Biol. Chem. 2005) 3 23

Products for RAMP3 Gene

Sources for RAMP3 Gene

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