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Aliases for RAMP3 Gene

Aliases for RAMP3 Gene

  • Receptor Activity Modifying Protein 3 2 3 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 4
  • Receptor (G Protein-Coupled) Activity Modifying Protein 3 2
  • Receptor (Calcitonin) Activity Modifying Protein 3 2
  • CRLR Activity-Modifying Protein 3 4

External Ids for RAMP3 Gene

Previous GeneCards Identifiers for RAMP3 Gene

  • GC07P044843
  • GC07P044938
  • GC07P044970

Summaries for RAMP3 Gene

Entrez Gene Summary for RAMP3 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP3 Gene

RAMP3 (Receptor Activity Modifying Protein 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP3 Gene

  • Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP3 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP3 Gene

Genomics for RAMP3 Gene

Regulatory Elements for RAMP3 Gene

Enhancers for RAMP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F044975 1.4 FANTOM5 ENCODE 10.8 -178.8 -178846 6.5 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 ZNF121 ZNF263 JUNB TBX21 PPARG CCM2 MYO1G ENSG00000260997 PURB RAMP3 SNHG15 OGDH ZMIZ2
GH07F045108 1.2 ENCODE 12 -46.8 -46834 4.0 PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NACAD SNHG15 CCM2 TBRG4 RAMP3 SNORA5B
GH07F044983 1.1 ENCODE 10.8 -172.1 -172129 5.2 PKNOX1 ARNT CREB3L1 WRNIP1 SIN3A ZNF2 YY1 CBX5 ZNF143 ZNF207 CCM2 SNHG15 ENSG00000260997 TBRG4 DDX56 RAMP3 GC07M044985 SNORA9
GH07F044982 0.5 ENCODE 10.8 -175.0 -175012 0.2 POLR2A WRNIP1 SUPT5H RAMP3 GC07M044985 MYO1G SNORA9
GH07F045205 0.5 FANTOM5 5.5 +47.4 47426 0.4 ZNF366 ZNF512 ZNF24 NFE2 RAMP3 MYO1G PURB GC07P045166 GC07M045182
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAMP3 on UCSC Golden Path with GeneCards custom track

Promoters for RAMP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001891673 132 1001 SUZ12 POLR2A KLF9 EZH2

Genomic Location for RAMP3 Gene

Chromosome:
7
Start:
45,157,768 bp from pter
End:
45,186,302 bp from pter
Size:
28,535 bases
Orientation:
Plus strand

Genomic View for RAMP3 Gene

Genes around RAMP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP3 Gene

Proteins for RAMP3 Gene

  • Protein details for RAMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60896-RAMP3_HUMAN
    Recommended name:
    Receptor activity-modifying protein 3
    Protein Accession:
    O60896
    Secondary Accessions:
    • Q7Z2Y1

    Protein attributes for RAMP3 Gene

    Size:
    148 amino acids
    Molecular mass:
    16518 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

neXtProt entry for RAMP3 Gene

Post-translational modifications for RAMP3 Gene

  • Glycosylation at Asn 29, Asn 58, Asn 71, and Asn 103

Other Protein References for RAMP3 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for RAMP3

No data available for DME Specific Peptides for RAMP3 Gene

Domains & Families for RAMP3 Gene

Protein Domains for RAMP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

O60896

UniProtKB/Swiss-Prot:

RAMP3_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP3: view

Function for RAMP3 Gene

Molecular function for RAMP3 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0005515 protein binding IPI 15613468
GO:0008565 protein transporter activity IEA,IDA 9620797
GO:0015026 coreceptor activity IEA --
genes like me logo Genes that share ontologies with RAMP3: view
genes like me logo Genes that share phenotypes with RAMP3: view

Animal Models for RAMP3 Gene

MGI Knock Outs for RAMP3:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAMP3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP3 Gene

Localization for RAMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP3 Gene

Cell membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAMP3 gene
Compartment Confidence
plasma membrane 5
lysosome 4
extracellular 3

Gene Ontology (GO) - Cellular Components for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA,IDA 23674134
GO:0005764 colocalizes_with lysosome IDA 15613468
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0009986 cell surface IDA 10882736
genes like me logo Genes that share ontologies with RAMP3: view

Pathways & Interactions for RAMP3 Gene

genes like me logo Genes that share pathways with RAMP3: view

Gene Ontology (GO) - Biological Process for RAMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IDA 15613468
GO:0006810 transport IEA --
GO:0006816 calcium ion transport IDA 10882736
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with RAMP3: view

No data available for SIGNOR curated interactions for RAMP3 Gene

Drugs & Compounds for RAMP3 Gene

(5) Drugs for RAMP3 Gene - From: DrugBank, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43
AC 187 Pharma Amylin receptor antagonist, Potent and selective, Potent and selective amylin receptor antagonist 0
CGRP (rat) Pharma Potent vasodilator 0
CGRP 8-37 (rat) Pharma CGRP1 receptor antagonist 0

(4) Additional Compounds for RAMP3 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
BIBN 4096
204697-65-4

(5) Tocris Compounds for RAMP3 Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist 151804-77-2
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
BIBN 4096 Potent and selective CGRP receptor antagonist 204697-65-4
CGRP (rat) Potent vasodilator 83651-90-5
CGRP 8-37 (rat) CGRP1 receptor antagonist 129121-73-9
genes like me logo Genes that share compounds with RAMP3: view

Transcripts for RAMP3 Gene

Unigene Clusters for RAMP3 Gene

Receptor (G protein-coupled) activity modifying protein 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RAMP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b
SP1: - - - -
SP2: -
SP3: - - - - -
SP4: - -
SP5:

Relevant External Links for RAMP3 Gene

GeneLoc Exon Structure for
RAMP3
ECgene alternative splicing isoforms for
RAMP3

Expression for RAMP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAMP3 Gene

mRNA differential expression in normal tissues according to GTEx for RAMP3 Gene

This gene is overexpressed in Lung (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of RAMP3 Gene:

RAMP3

SOURCE GeneReport for Unigene cluster for RAMP3 Gene:

Hs.25691

mRNA Expression by UniProt/SwissProt for RAMP3 Gene:

O60896-RAMP3_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.
genes like me logo Genes that share expression patterns with RAMP3: view

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for RAMP3 Gene

Orthologs for RAMP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAMP3 34 35
  • 99.1 (n)
mouse
(Mus musculus)
Mammalia Ramp3 34 16 35
  • 84.87 (n)
dog
(Canis familiaris)
Mammalia LOC100855938 34
  • 83.94 (n)
RAMP3 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp3 34
  • 82.31 (n)
cow
(Bos Taurus)
Mammalia RAMP3 34 35
  • 79.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAMP3 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAMP3 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAMP3 34 35
  • 66.39 (n)
lizard
(Anolis carolinensis)
Reptilia RAMP3 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp3 34
  • 56.8 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-334d15.2 35
  • 22 (a)
ManyToMany
Species where no ortholog for RAMP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP3 Gene

ENSEMBL:
Gene Tree for RAMP3 (if available)
TreeFam:
Gene Tree for RAMP3 (if available)

Paralogs for RAMP3 Gene

Paralogs for RAMP3 Gene

(2) SIMAP similar genes for RAMP3 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP3: view

Variants for RAMP3 Gene

Sequence variations from dbSNP and Humsavar for RAMP3 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10248761 -- 45,161,917(+) GAGAC(C/T)CACCC intron-variant
rs10248889 -- 45,162,007(+) GCGAA(C/T)CTTCA intron-variant
rs10249390 -- 45,162,246(+) GGCAT(G/T)ATGTT intron-variant
rs10256469 -- 45,163,572(+) GGAGG(C/T)TGGGG intron-variant
rs10256672 -- 45,163,538(+) GTCGT(A/G)GAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP3 Gene

Variant ID Type Subtype PubMed ID
nsv950209 CNV deletion 24416366
nsv830986 CNV loss 17160897
nsv516731 CNV loss 19592680
esv3613016 CNV loss 21293372
esv28566 CNV gain 19812545

Variation tolerance for RAMP3 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.78; 66.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAMP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP3 Gene

Disorders for RAMP3 Gene

Relevant External Links for RAMP3

Genetic Association Database (GAD)
RAMP3
Human Genome Epidemiology (HuGE) Navigator
RAMP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAMP3

No disorders were found for RAMP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAMP3 Gene

Publications for RAMP3 Gene

  1. G-protein-coupled receptor 30 interacts with receptor activity- modifying protein 3 and confers sex-dependent cardioprotection. (PMID: 23674134) Lenhart P.M. … Caron K.M. (J. Mol. Endocrinol. 2013) 3 4 64
  2. Functional characterization of two human receptor activity-modifying protein 3 variants. (PMID: 20034525) Bailey R.J. … Hay D.L. (Peptides 2010) 3 22 64
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  4. Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. (PMID: 19886671) Harikumar K.G. … Miller L.J. (Biochemistry 2009) 3 22 64
  5. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 22 64

Products for RAMP3 Gene

Sources for RAMP3 Gene

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