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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAMP2 Gene

protein-coding GIFtS: 59
GCID: GC17P040913

receptor (G protein-coupled) activity modifying protein...

(Previous names: receptor activity modifying protein 2, receptor (calcitonin)...)

Explore 22 diseases affiliated with
RAMP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Receptor (G Protein-Coupled) Activity Modifying Protein 2¹ ²		CRLR Activity-Modifying Protein 2² ³
Receptor (Calcitonin) Activity Modifying Protein 2¹ ²		Calcitonin Receptor-Like Receptor Activity Modifying Protein 2²
Receptor Activity Modifying Protein 2¹ ²		Receptor Activity-Modifying Protein 2²
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2² ³		Receptor-Activity-Modifying Protein 2²

External Ids:	HGNC: 9844¹	Entrez Gene: 10266²	Ensembl: ENSG00000131477⁷	OMIM: 605154⁵	UniProtKB: O60895³

Export aliases for RAMP2 gene to outside databases

Previous GC identifers: GC17P040484 GC17P043075 GC17P040821 GC17P041286 GC17P038166 GC17P036678

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAMP2:

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called

receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an

extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like

receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a

calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP

family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2

protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a

receptor for adrenomedullin (AM) together with CALCRL

summary for RAMP2:

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight

subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;

high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels

present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit

bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT

receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II

diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form

the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main

function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010783.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAMP2 gene promoter:
STAT5B MAZR AP-4 CUTL1 LCR-F1 PPAR-gamma1 FOXJ2 (long isoform) PPAR-gamma2 FOXJ2 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAMP2 promoter sequence

Search SABiosciences Chromatin IP Primers for RAMP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAMP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q12-q21.1

RAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAMP2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040913: view genomic region (about GC identifiers)

Start:	40,910,465 bp from pter	End:	40,915,059 bp from pter
Size:	4,595 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895 (See protein sequence)

Recommended Name: Receptor activity-modifying protein 2 precursor

Size: 175 amino acids; 19608 Da

Subunit: Heterodimer of CALCRL and RAMP2 (By similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

3 PDB 3D structures from and Proteopedia for RAMP2:

2XVT (3D)

3AQE (3D)

3AQF (3D)

Secondary accessions: Q8N1F2

Explore the universe of human proteins at neXtProt for RAMP2: NX_O60895

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60895

RAMP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005845.2

ENSEMBL proteins:

ENSP00000467463 ENSP00000466980 ENSP00000253796 ENSP00000466455 ENSP00000465725

Reactome Protein details: O60895
Human Recombinant Protein Products:

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	Uscn Proteins for RAMP2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10882736
GO:0005764	lysosome	TAS	10882736
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9620797
GO:0005905	coated pit	TAS	10882736

RAMP2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAMP2 for domains About GeneDecksing

1 InterPro domain/family:

IPR006985 RAMP

Graphical View of Domain Structure for InterPro Entry O60895

ProtoNet protein and cluster: O60895

1 Blocks protein family: IPB006985 Receptor activity modifying protein

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Similarity: Belongs to the RAMP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a

receptor for adrenomedullin (AM) together with CALCRL

miRNA Products:		OriGene 3'-UTR Clone: RAMP2 Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAMP2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008565	protein transporter activity	IDA	10882736
GO:0015026	coreceptor activity	ISS	--

RAMP2 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for RAMP2:

Increased cell number in S

Animal Models:
Mouse knock-outs for RAMP2: Ramp2^tm1.1Tash Ramp2^tm1Kmca
11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ramp2):

cardiovascular system	embryogenesis	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	no phenotypic analysis
reproductive system

RAMP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

Calcium Regulation in the Cardiac Cell

Myometrial Relaxation and Contraction Pathways

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for RAMP2

Myometrial Relaxation and Contraction Pathways

5/7 Reactome Pathways for RAMP2 (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	Calcitonin-like ligand receptors
	GPCR ligand binding

1 Kegg Pathway (Kegg details for RAMP2):

Vascular smooth muscle contraction

RAMP2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAMP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for RAMP2 (O60895³ ENSP00000253796⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCA	P01258³, ENSP00000331746⁴	I2D: score=1 STRING: ENSP00000331746
CALCRL	Q16602³, ENSP00000376177⁴	I2D: score=1 STRING: ENSP00000376177
IAPP	P10997³, ENSP00000240652⁴	I2D: score=2 STRING: ENSP00000240652
VIPR1	P32241³, ENSP00000327246⁴	I2D: score=1 STRING: ENSP00000327246
SLC31A2	O15432³, ENSP00000259392⁴	I2D: score=1 STRING: ENSP00000259392

About this table

Gene Ontology (GO): 5/29 biological process terms (GO ID links to tree view) (see all 29): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	--
GO:0001570	vasculogenesis	IMP	16964401
GO:0001666	response to hypoxia	IEA	--
GO:0002040	sprouting angiogenesis	ISS	--
GO:0006171	cAMP biosynthetic process	IDA	--

RAMP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RAMP2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for RAMP2 available from Tocris Bioscience About this table

Compound	Action	CAS #
Amylin	Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors	[122384-88-7]
AC 187	Potent and selective amylin receptor antagonist	[151804-77-2]

1 DrugBank Compound for RAMP2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pramlintide	--	151126-32-8	target	agonist	19273748 15494035 17139284 18593822 17016423 20015292

3 Novoseek chemical compound relationships for RAMP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	87.4	1	12183333 (1)
adenylate	19.4	1	14631146 (1)
dexamethasone	0	6	10772950 (3), 15358098 (1)

Search CenterWatch for drugs/clinical trials and news about RAMP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAMP2 gene:

NM_005854.2

Unigene Cluster for RAMP2:

Receptor (G protein-coupled) activity modifying protein 2

Hs.514193 [show with all ESTs]

Unigene Representative Sequence: BX420269

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591972 ENST00000589683 ENST00000588928 ENST00000253796(uc002ibg.3 uc010cyt.3 uc021txv.1)

ENST00000587142 ENST00000588576

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Additional cDNA sequence:

AJ001015.1 AY265458.1 BC027975.1 EF687002.1

3 DOTS entries:

DT.312550 DT.95270519 DT.100777069

24/52 AceView cDNA sequences (see all 52):

BC027975 AI221727 CR590147 BX280360 AY265458 BG997107 BQ186604 AA506528

CR621805 AI832299 AV727009 T96173 AA367431 AA622338 N89639 BI837130

N91571 BV184756 AI418304 AA457474 AL548945 AA778001 AA865325 BX420269

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAMP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACAAGTTC

About this image

RAMP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Cardiac Crescent

Cardiac Crescent Cells

Myocardium

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Brain

Heart

Heart

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

Extraembryonic endoderm-like cells (Generation of extrae...)

See RAMP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAMP2

SOURCE GeneReport for Unigene cluster: Hs.514193

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAMP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 gene from 4/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ramp2^{1 , 5}	receptor (calcitonin) activity modifying protein 2^{1, 5}	75.29(n)¹ 68.39(a)¹		11 (64.47 cM)⁵ 54409¹ NM_019444.2¹ NP_062317.1¹ 101246028⁵
chicken (Gallus gallus)	Aves	RAMP2¹	receptor (G protein-coupled) activity modifying protein more	56.48(n) 46.53(a)		420022 NM_001105610.1 NP_001099080.1
lizard (Anolis carolinensis)	Reptilia	RAMP2⁶	--	50(a)	1 ↔ 1	6(62018951-62021771)
zebrafish (Danio rerio)	Actinopterygii	ramp2⁶	receptor (G protein-coupled) activity modifying pr...	20(a)	1 ↔ 1	3(36831493-36841270)

ENSEMBL Gene Tree for RAMP2 (if available)
TreeFam Gene Tree for RAMP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAMP2 gene

RAMP3² RAMP1²

2 SIMAP similar genes for RAMP2 using alignment to 6 protein entries: RAMP2_HUMAN (see all proteins):

RAMP1 RAMP3

RAMP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs35672993^1,2	C,	--	40911425(+)	`TATAGT/-TTTTT`	3	--	us2k¹ int¹		1		CSA	2
rs187925594^1,2		--	40911504(+)	`CCTTTA/CATCTT`	3	--	int¹ us2k¹		0	--	--	--	--
rs142047961^1,2		--	40911558(+)	`TGGCCC/TCAACC`	3	--	int¹ us2k¹		0	--	--	--	--
rs115196008^1,2	C,F,	--	40911670(+)	`AGGCAG/AGCAGG`	3	--	int¹ us2k¹		1		WA	118
rs78873446^1,2	C,	--	40911757(+)	`CTTACA/CAGGAG`	3	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs3840868^1,2	C,	--	40911776(-)	`TGACG-/TGAACT`	3	--	nc-transcript-variantus2k¹		1		CSA	2
rs192440176^1,2		--	40911784(+)	`TCAAGA/CAGGCC`	3	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs182965785^1,2		--	40911797(+)	`TGACTC/TTCTCC`	3	--	nc-transcript-variantus2k¹		0	--	--	--	--
rs73983758^1,2	C,	--	40912138(+)	`TCAGGA/GCCCCC`	3	--	int¹ us2k¹		5		WA CSA EA	242
rs187673375^1,2		--	40912209(+)	`GAAAAA/GAGGAA`	3	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAMP2 (40910465 - 40915059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAMP2: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RAMP2 for disorders           About GeneDecksing

OMIM gene information: 605154    OMIM disorders: --

20/22 diseases for RAMP2 (see all 22):    About MalaCards

acute closed-angle glaucoma angle-closure glaucoma thyroiditis glaucoma

essential hypertension myocardial infarction chorioamnionitis pheochromocytoma

rheumatoid arthritis sepsis endometrial cancer glioblastoma

hypertension arthritis pancreatic cancer lung cancer

pancreatitis cerebritis hypoxia neuroblastoma

8 Novoseek disease relationships for RAMP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	46.1	1	17102095 (1)
glioblastoma	22.2	2	11943713 (1)
neovascularization	21.3	1	18097473 (1)
cardiovascular diseases	0	1	18198792 (1)
sepsis	0	1	11754970 (1)
glioma	0	1	11943713 (1)
tumors	0	5	17671114 (1), 19610056 (1)
heart failure	0	4	15300632 (2)

Human Genome Epidemiology (HuGE) Navigator: RAMP2 (5 documents)

Export disorders for RAMP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAMP2 gene, integrated from 9 sources (see all 125):
(articles sorted by number of sources associating them with RAMP2)

Utopia: connect your pdf to the dynamic
world of online information

Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PubMed id 18593822)^{1, 7, 9} Qi T....Hay D.L. (2008)
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PubMed id 22102369)^{1, 2} Kusano S.... Yokoyama S. (2012)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PubMed id 9620797)^{1, 2} McLatchie L.M.... Foord S.M. (1998)
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. (PubMed id 17671114)^{1, 9} Yue W....Zhang L. (2007)
Gene silencing of human RAMP2 mediated by short-interfering RNA. (PubMed id 16964401)^{1, 9} Albertin G....Nussdorfer G.G. (2006)
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PubMed id 18097473)^{1, 9} Ichikawa-Shindo Y....Shindo T. (2008)
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PubMed id 20074556)^{1, 9} Kuwasako K....Kato J. (2010)
[Increased atria expression of receptor activity-modifying proteins in heart failure patients] (PubMed id 15300632)^{1, 9} Wang Y.F....Wang S.R. (2004)
The role of the CGRP-receptor component protein (RCP) in adrenomedullin receptor signal transduction. (PubMed id 11754963)^{1, 9} Prado M.A....Dickerson I.M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10266	HGNC: 9844	AceView: RAMP2	Ensembl:ENSG00000131477	euGenes: HUgn10266
ECgene: RAMP2	Kegg: 10266	H-InvDB: RAMP2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAMP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAMP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RAMP2 gene:
Search GeneIP for patents involving RAMP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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