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RAMP2 Gene(Protein Coding)

Receptor Activity Modifying Protein 2

GCID:
GC17P042758
GIFtS:
62
Genes Participants
UDN Logo

Aliases for RAMP2 Gene

Aliases for RAMP2 Gene

  • Receptor Activity Modifying Protein 2 2 3
  • Receptor (G Protein-Coupled) Activity Modifying Protein 2 2 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 4
  • Receptor (Calcitonin) Activity Modifying Protein 2 2
  • CRLR Activity-Modifying Protein 2 4

External Ids for RAMP2 Gene

Previous GeneCards Identifiers for RAMP2 Gene

  • GC17P040484
  • GC17P043075
  • GC17P040821
  • GC17P041286
  • GC17P038166
  • GC17P040913
  • GC17P036678

Summaries for RAMP2 Gene

Entrez Gene Summary for RAMP2 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP2 Gene

RAMP2 (Receptor Activity Modifying Protein 2) is a Protein Coding gene. Diseases associated with RAMP2 include Pheochromocytoma. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. GO annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP2 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP2 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP2 Gene

Genomics for RAMP2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for RAMP2 Gene

Enhancers for RAMP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RAMP2 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the RAMP2 gene promoter:

Genomic Location for RAMP2 Gene

Chromosome:
17
Start:
42,758,447 bp from pter
End:
42,763,041 bp from pter
Size:
4,595 bases
Orientation:
Plus strand

Genomic View for RAMP2 Gene

Genes around RAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RAMP2 Gene

Proteins for RAMP2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for RAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60895-RAMP2_HUMAN
    Recommended name:
    Receptor activity-modifying protein 2
    Protein Accession:
    O60895
    Secondary Accessions:
    • A7L9S6
    • K7EMD3
    • Q8N1F2

    Protein attributes for RAMP2 Gene

    Size:
    175 amino acids
    Molecular mass:
    19608 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP2.

    Three dimensional structures from OCA and Proteopedia for RAMP2 Gene

    Alternative splice isoforms for RAMP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAMP2 Gene

Proteomics data for RAMP2 Gene at MOPED

Protein Expression for RAMP2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RAMP2 Gene

  • Glycosylation at Asn 130
  • Modification sites at PhosphoSitePlus

Other Protein References for RAMP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAMP2 Gene

Domains & Families for RAMP2 Gene

Gene Families for RAMP2 Gene

HGNC:

Protein Domains for RAMP2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RAMP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60895

UniProtKB/Swiss-Prot:

RAMP2_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP2: view

Function for RAMP2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for RAMP2 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Phenotypes for RAMP2 Gene

MGI mutant phenotypes for RAMP2:
inferred from 3 alleles
GenomeRNAi human phenotypes for RAMP2:
genes like me logo Genes that share phenotypes with RAMP2: view

Animal Models for RAMP2 Gene

MGI Knock Outs for RAMP2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP2 Gene

Localization for RAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAMP2 Gene COMPARTMENTS Subcellular localization image for RAMP2 gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5
cytosol 2
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for RAMP2 Gene

Pathways & Interactions for RAMP2 Gene

genes like me logo Genes that share pathways with RAMP2: view

Gene Ontology (GO) - Biological Process for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0001570 vasculogenesis IMP 16964401
GO:0001666 response to hypoxia IEA --
GO:0006171 cAMP biosynthetic process IDA 20074556
GO:0006816 calcium ion transport IDA 10882736
genes like me logo Genes that share ontologies with RAMP2: view

No data available for SIGNOR curated interactions for RAMP2 Gene

Drugs & Compounds for RAMP2 Gene

Products:

  1. Drug

(2) Drugs for RAMP2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43

(7) Additional Compounds for RAMP2 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
PHM 27 (human)
118025-43-7
SUN-B 8155
345893-91-6

(5) Tocris Compounds for RAMP2 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP2: view

Transcripts for RAMP2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for RAMP2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAMP2 Gene

Receptor (G protein-coupled) activity modifying protein 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP2 Gene

No ASD Table

Relevant External Links for RAMP2 Gene

GeneLoc Exon Structure for
RAMP2
ECgene alternative splicing isoforms for
RAMP2

Expression for RAMP2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for RAMP2 Gene

mRNA expression in normal human tissues for RAMP2 Gene
mRNA expression by BioGPS for RAMP2 GenemRNA expression by GTEx for RAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for RAMP2 Gene

This gene is overexpressed in Fetal gut (58.3) and Fetal heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAMP2 Gene



SOURCE GeneReport for Unigene cluster for RAMP2 Gene Hs.514193

mRNA Expression by UniProt/SwissProt for RAMP2 Gene

O60895-RAMP2_HUMAN
Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.
genes like me logo Genes that share expression patterns with RAMP2: view

Protein tissue co-expression partners for RAMP2 Gene

- Elite partner

Primer Products

Orthologs for RAMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia RAMP2 35
  • 83.72 (n)
  • 78.74 (a)
RAMP2 36
  • 62 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia RAMP2 35
  • 84.95 (n)
  • 80 (a)
-- 36
  • 63 (a)
 OneToMany
-- 36
  • 67 (a)
 OneToMany
mouse
(Mus musculus)
 Mammalia Ramp2 35
  • 75.29 (n)
  • 68.39 (a)
Ramp2 16
Ramp2 36
  • 50 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia RAMP2 35
  • 97.71 (n)
  • 96.55 (a)
RAMP2 36
  • 97 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ramp2 35
  • 77.26 (n)
  • 68.79 (a)
oppossum
(Monodelphis domestica)
 Mammalia RAMP2 36
  • 45 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RAMP2 35
  • 62.28 (n)
  • 53.51 (a)
RAMP2 36
  • 39 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RAMP2 36
  • 50 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii ramp2 36
  • 19 (a)
 OneToOne
Species with no ortholog for RAMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP2 Gene

ENSEMBL:
Gene Tree for RAMP2 (if available)
TreeFam:
Gene Tree for RAMP2 (if available)

Paralogs for RAMP2 Gene

Paralogs for RAMP2 Gene

(2) SIMAP similar genes for RAMP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP2: view

Variants for RAMP2 Gene

Sequence variations from dbSNP and Humsavar for RAMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs9893425 -- 42,763,539(+) CTCCA(C/T)GTCCC downstream-variant-500B
rs74965130 -- 42,763,485(+) TCACA(A/G)TTGAG downstream-variant-500B
rs372416317 -- 42,763,499(+) GAAAG(A/C)AGTGG downstream-variant-500B
rs368372337 -- 42,763,270(+) AGAGA(A/C)TCCCT downstream-variant-500B
rs545836580 -- 42,763,354(+) TGTGA(C/G)TCCTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAMP2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv833450 CNV Loss 17160897
nsv908257 CNV Loss 21882294

Variation tolerance for RAMP2 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RAMP2 Gene

Disorders for RAMP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAMP2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search RAMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAMP2

Genetic Association Database (GAD)
RAMP2
Human Genome Epidemiology (HuGE) Navigator
RAMP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAMP2
genes like me logo Genes that share disorders with RAMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAMP2 Gene

Publications for RAMP2 Gene

  1. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L. … LiotAc F. (Clin. Exp. Rheumatol. 2008) 3 23 48 67
  2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  3. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PMID: 20074556) Kuwasako K. … Kato J. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (PMID: 20015292) Qi T. … Hay D.L. (Br. J. Pharmacol. 2010) 23 25
  5. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PMID: 18097473) Ichikawa-Shindo Y. … Shindo T. (J. Clin. Invest. 2008) 3 23

Products for RAMP2 Gene

  • Addgene plasmids for RAMP2

Sources for RAMP2 Gene

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