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Aliases for RAMP2 Gene

Aliases for RAMP2 Gene

  • Receptor Activity Modifying Protein 2 2 3 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 4
  • Receptor (G Protein-Coupled) Activity Modifying Protein 2 2
  • Receptor (Calcitonin) Activity Modifying Protein 2 2
  • CRLR Activity-Modifying Protein 2 4

External Ids for RAMP2 Gene

Previous GeneCards Identifiers for RAMP2 Gene

  • GC17P040484
  • GC17P043075
  • GC17P040821
  • GC17P041286
  • GC17P038166
  • GC17P040913
  • GC17P036678

Summaries for RAMP2 Gene

Entrez Gene Summary for RAMP2 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP2 Gene

RAMP2 (Receptor Activity Modifying Protein 2) is a Protein Coding gene. Diseases associated with RAMP2 include Pheochromocytoma. Among its related pathways are G alpha (s) signalling events and Signaling by GPCR. GO annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP3.

UniProtKB/Swiss-Prot for RAMP2 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP2 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP2 Gene

Additional gene information for RAMP2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP2 Gene

Genomics for RAMP2 Gene

Regulatory Elements for RAMP2 Gene

Enhancers for RAMP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H043455 1.5 Ensembl ENCODE dbSUPER 10.7 +698.9 698947 4.4 PKNOX1 FOXA2 ATF1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF207 ATF7 DHX8 RAMP2-AS1 HMGN2P15 ETV4 MIR2117HG RNU6-470P ARL4D RNU6-1137P PLEKHH3 LINC00910
GH17H042672 1.4 ENCODE dbSUPER 11.4 -79.8 -79750 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 CNTNAP1 TUBG2 ENSG00000267340 ENSG00000267002 HSD17B1 HSD17B1P1 HMGN2P15 ENSG00000259623 MLX KAT2A
GH17H042928 1.3 Ensembl ENCODE 10.7 +170.6 170621 1.8 HDGF ATF1 FOXA2 ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 GATA2 G6PC LINC00671 RNU6-287P AOC3 AOC2 CNTD1 COA3 VPS25 RAMP2-AS1 HMGN2P15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAMP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RAMP2 Gene

Genomic Locations for RAMP2 Gene
4,595 bases
Plus strand

Genomic View for RAMP2 Gene

Genes around RAMP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP2 Gene

Proteins for RAMP2 Gene

  • Protein details for RAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor activity-modifying protein 2
    Protein Accession:
    Secondary Accessions:
    • A7L9S6
    • K7EMD3
    • Q8N1F2

    Protein attributes for RAMP2 Gene

    175 amino acids
    Molecular mass:
    19608 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP2.

    Three dimensional structures from OCA and Proteopedia for RAMP2 Gene

    Alternative splice isoforms for RAMP2 Gene


neXtProt entry for RAMP2 Gene

Post-translational modifications for RAMP2 Gene

  • Glycosylation at isoforms=2130
  • Modification sites at PhosphoSitePlus

Other Protein References for RAMP2 Gene

No data available for DME Specific Peptides for RAMP2 Gene

Domains & Families for RAMP2 Gene

Gene Families for RAMP2 Gene

Human Protein Atlas (HPA):
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RAMP2 Gene


Suggested Antigen Peptide Sequences for RAMP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RAMP family.
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP2: view

Function for RAMP2 Gene

Molecular function for RAMP2 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9620797
GO:0008565 protein transporter activity IDA 9620797
GO:0015026 coreceptor activity ISS --
GO:0097643 contributes_to amylin receptor activity IGI 22500019
genes like me logo Genes that share ontologies with RAMP2: view
genes like me logo Genes that share phenotypes with RAMP2: view

Animal Models for RAMP2 Gene

MGI Knock Outs for RAMP2:

Clone Products

  • Addgene plasmids for RAMP2

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP2 Gene

Localization for RAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAMP2 gene
Compartment Confidence
plasma membrane 5
lysosome 5
mitochondrion 2
cytosol 2
extracellular 1
cytoskeleton 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IDA 10882736
GO:0005764 lysosome TAS 10882736
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
genes like me logo Genes that share ontologies with RAMP2: view

Pathways & Interactions for RAMP2 Gene

genes like me logo Genes that share pathways with RAMP2: view

Gene Ontology (GO) - Biological Process for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0001570 vasculogenesis IMP 16964401
GO:0001666 response to hypoxia IEA --
GO:0002040 sprouting angiogenesis ISS --
GO:0006171 cAMP biosynthetic process IDA 20074556
genes like me logo Genes that share ontologies with RAMP2: view

No data available for SIGNOR curated interactions for RAMP2 Gene

Drugs & Compounds for RAMP2 Gene

(5) Drugs for RAMP2 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 43

(4) Additional Compounds for RAMP2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for RAMP2 Gene

Compound Action Cas Number
alpha-CGRP (human) CGRP receptor agonist 90954-53-3
Calcitonin (salmon) Affects bone formation and resorption 47931-85-1
CGRP (rat) Potent vasodilator 83651-90-5
PHM 27 (human) Potent calcitonin receptor agonist; endogenous analog of human VIP 118025-43-7
SUN-B 8155 Non-peptide calcitonin (CT) receptor agonist 345893-91-6
genes like me logo Genes that share compounds with RAMP2: view

Transcripts for RAMP2 Gene

Unigene Clusters for RAMP2 Gene

Receptor (G protein-coupled) activity modifying protein 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAMP2

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP2 Gene

No ASD Table

Relevant External Links for RAMP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAMP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.1).

Protein differential expression in normal tissues from HIPED for RAMP2 Gene

This gene is overexpressed in Fetal gut (58.3) and Fetal heart (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAMP2 Gene

Protein tissue co-expression partners for RAMP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAMP2 Gene:


SOURCE GeneReport for Unigene cluster for RAMP2 Gene:


mRNA Expression by UniProt/SwissProt for RAMP2 Gene:

Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.

Evidence on tissue expression from TISSUES for RAMP2 Gene

  • Heart(4.6)
  • Pancreas(4.1)
  • Muscle(2.7)
  • Kidney(2.6)
  • Lung(2.5)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RAMP2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAMP2 Gene

Orthologs for RAMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAMP2 33 34
  • 97.71 (n)
(Canis familiaris)
Mammalia RAMP2 33
  • 84.95 (n)
-- 34
  • 67 (a)
-- 34
  • 63 (a)
(Bos Taurus)
Mammalia RAMP2 33 34
  • 83.72 (n)
(Rattus norvegicus)
Mammalia Ramp2 33
  • 77.26 (n)
(Mus musculus)
Mammalia Ramp2 33 16 34
  • 75.29 (n)
(Monodelphis domestica)
Mammalia RAMP2 34
  • 45 (a)
(Gallus gallus)
Aves RAMP2 33 34
  • 62.28 (n)
(Anolis carolinensis)
Reptilia RAMP2 34
  • 50 (a)
(Danio rerio)
Actinopterygii ramp2 34
  • 19 (a)
Species where no ortholog for RAMP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP2 Gene

Gene Tree for RAMP2 (if available)
Gene Tree for RAMP2 (if available)

Paralogs for RAMP2 Gene

Paralogs for RAMP2 Gene

(2) SIMAP similar genes for RAMP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP2: view

Variants for RAMP2 Gene

Sequence variations from dbSNP and Humsavar for RAMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000250435 -- 42,762,272(+) ACAGG(C/T)AGTTC intron-variant, upstream-variant-2KB
rs1003471186 -- 42,761,167(+) GAAGC(A/G)GCGCG nc-transcript-variant, upstream-variant-2KB
rs1004091198 -- 42,759,242(+) CATTA(C/T)GCCAT intron-variant, upstream-variant-2KB
rs1005343641 -- 42,761,628(+) GATGA(A/G)GGGGC intron-variant, upstream-variant-2KB
rs1006294113 -- 42,760,837(+) CTCCC(C/T)CTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAMP2 Gene

Variant ID Type Subtype PubMed ID
nsv833450 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
esv33998 OTHER inversion 15654335

Variation tolerance for RAMP2 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAMP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP2 Gene

Disorders for RAMP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAMP2 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
  • pheochromocytoma, modifier of
- elite association - COSMIC cancer census association via MalaCards
Search RAMP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAMP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAMP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAMP2 Gene

Publications for RAMP2 Gene

  1. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L … Lioté F (Clinical and experimental rheumatology 2008) 3 22 45 60
  2. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PMID: 22102369) Kusano S … Yokoyama S (Protein science : a publication of the Protein Society 2012) 3 4 60
  3. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PMID: 20074556) Kuwasako K … Kato J (Biochemical and biophysical research communications 2010) 3 22 60
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  5. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PMID: 18097473) Ichikawa-Shindo Y … Shindo T (The Journal of clinical investigation 2008) 3 22 60

Products for RAMP2 Gene

Sources for RAMP2 Gene

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