Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

RAMP2 Gene

protein-coding GIFtS: 62
GCID: GC17P040913

Receptor (G Protein-Coupled) Activity Modifying Protein...

(Previous names: receptor activity modifying protein 2, receptor (calcitonin)...)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Receptor (G Protein-Coupled) Activity Modifying Protein 2¹ ²		CRLR Activity-Modifying Protein 2² ³
Receptor (Calcitonin) Activity Modifying Protein 2¹ ²		Calcitonin Receptor-Like Receptor Activity Modifying Protein 2²
Receptor Activity Modifying Protein 2¹ ²		Receptor Activity-Modifying Protein 2²
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2² ³		Receptor-Activity-Modifying Protein 2²

External Ids:	HGNC: 9844¹	Entrez Gene: 10266²	Ensembl: ENSG00000131477⁷	OMIM: 605154⁵	UniProtKB: O60895³

Export aliases for RAMP2 gene to outside databases

Previous GC identifers: GC17P040484 GC17P043075 GC17P040821 GC17P041286 GC17P038166 GC17P036678

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAMP2 Gene:

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called

receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an

extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like

receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either

a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of

the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin

receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to

the cell surface. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAMP2 Gene:

RAMP2 (receptor (G protein-coupled) activity modifying protein 2) is a protein-coding gene. Diseases associated with RAMP2 include acute closed-angle glaucoma, and chorioamnionitis. GO annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP3.

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as

a receptor for adrenomedullin (AM) together with CALCRL

summary for RAMP2 Gene:

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight

subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;

high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels

present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit

bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT

receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II

diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form

the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main

function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000017.11 NC_018928.2 NT_010783.16

Regulatory elements:

Regulatory transcription factor binding sites in the RAMP2 gene promoter:
STAT5B MAZR AP-4 CUTL1 LCR-F1 PPAR-gamma1 FOXJ2 (long isoform) PPAR-gamma2 FOXJ2 Hlf
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAMP2 promoter sequence

Search Chromatin IP Primers for RAMP2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAMP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q12-q21.1

RAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAMP2 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P040913: view genomic region (about GC identifiers)

Start:	40,910,465 bp from pter	End:	40,915,059 bp from pter
Size:	4,595 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895 (See protein sequence)

Recommended Name: Receptor activity-modifying protein 2 precursor

Size: 175 amino acids; 19608 Da

Subunit: Heterodimer of CALCRL and RAMP2 (By similarity)

3 PDB 3D structures from and Proteopedia for RAMP2:

2XVT (3D)

3AQE (3D)

3AQF (3D)

Secondary accessions: Q8N1F2

Explore the universe of human proteins at neXtProt for RAMP2: NX_O60895

Explore proteomics data for RAMP2 at MOPED

Post-translational modifications:

Glycosylation² at Asn130

Modification sites at PhosphoSitePlus

See RAMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_005845.2

ENSEMBL proteins:

ENSP00000467463 ENSP00000466980 ENSP00000253796 ENSP00000466455 ENSP00000465725

Reactome Protein details: O60895

RAMP2 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for RAMP2 OriGene Custom MassSpec OriGene Custom Protein Services for RAMP2
	GenScript Custom Purified and Recombinant Proteins Services for RAMP2
	Novus Biologicals RAMP2 Proteins Novus Biologicals RAMP2 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for RAMP2

RAMP2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RAMP2
	OriGene Antibodies for RAMP2 OriGene Custom Antibody Services for RAMP2
	Novus Biologicals RAMP2 Antibodies
	Abcam antibodies for RAMP2
	Cloud-Clone Corp. Antibodies for RAMP2
	ThermoFisher Antibodies for RAMP2
	LSBio Antibodies in human, mouse, rat for RAMP2

RAMP2 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RAMP2
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RAMP2
	Browse Enzo Life Sciences for kits & assays
	Cloud-Clone Corp. ELISAs for RAMP2 Cloud-Clone Corp. CLIAs for RAMP2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

RAMP: Receptor (G protein-coupled) activity modifying proteins

IUPHAR Guide to PHARMACOLOGY protein family classification: RAMP2

1 InterPro protein domain:

IPR006985 RAMP

Graphical View of Domain Structure for InterPro Entry O60895

ProtoNet protein and cluster: O60895

1 Blocks protein domain: IPB006985 Receptor activity modifying protein

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Similarity: Belongs to the RAMP family

RAMP2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: RAMP2_HUMAN, O60895

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as

a receptor for adrenomedullin (AM) together with CALCRL

Gene Ontology (GO): 3 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0008565	protein transporter activity	IDA	10882736
GO:0015026	coreceptor activity	ISS	--

RAMP2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for RAMP2:

Increased cell number in S

11 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ramp2):

cardiovascular system	embryogenesis	homeostasis/metabolism	immune system	integument
liver/biliary system	mortality/aging	muscle	nervous system	no phenotypic analysis
reproductive system

RAMP2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-outs for RAMP2: Ramp2^tm1.1Tash Ramp2^tm1Kmca

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAMP2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAMP2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAMP2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAMP2

miRNA Products:		Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate RAMP2
		SwitchGear 3'UTR luciferase reporter plasmid: RAMP2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RAMP2
		Predesigned siRNA for gene silencing in human, mouse, rat RAMP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RAMP2

Clone Products:		OriGene clones in human, mouse for RAMP2 (see all 7) OriGene ORF clones in mouse, rat for RAMP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAMP2 (NM_005854)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAMP2
		Browse ESI BIO Cell Lines and PureStem Progenitors for RAMP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

RAMP2_HUMAN, O60895: Membrane; Single-pass type I membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
lysosome	4
plasma membrane	4
vacuole	4
cytosol	2
mitochondrion	2
cytoskeleton	1
extracellular	1
nucleus	1

About this image

Gene Ontology (GO): Selected cellular component terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	10882736
GO:0005764	lysosome	TAS	10882736
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral component of plasma membrane	TAS	9620797
GO:0005905	coated pit	TAS	10882736

RAMP2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RAMP2 About (see all 6)

See pathways by source

SuperPath

Contained pathways About

Signaling by GPCR

	Signaling by GPCR	0.90			Signal Transduction	0.58
	GPCR downstream signaling	0.90

ADP signalling through P2Y purinoceptor 12

Class B/2 (Secretin family receptors)

0.36

Calcitonin-like ligand receptors

0.00

Peptide ligand-binding receptors

GPCR ligand binding

0.71

Myometrial Relaxation and Contraction Pathways

Myometrial Relaxation and Contraction Pathways

0.43

Oxytocin signaling pathway

Vascular smooth muscle contraction

0.32

Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for RAMP2

Myometrial Relaxation and Contraction Pathways

2 Reactome Pathways for RAMP2

	Calcitonin-like ligand receptors
	G alpha (s) signalling events

1 Kegg Pathway (Kegg details for RAMP2):

Vascular smooth muscle contraction

RAMP2 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RAMP2
Interactions:

GeneGlobe Interaction Network for RAMP2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

Selected Interacting proteins for RAMP2 (O60895³ ENSP00000253796⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCA	P01258³, ENSP00000331746⁴	I2D: score=1 STRING: ENSP00000331746
CALCRL	Q16602³, ENSP00000376177⁴	I2D: score=1 STRING: ENSP00000376177
IAPP	P10997³, ENSP00000240652⁴	I2D: score=2 STRING: ENSP00000240652
VIPR1	P32241³, ENSP00000327246⁴	I2D: score=1 STRING: ENSP00000327246
SLC31A2	O15432³, ENSP00000259392⁴	I2D: score=1 STRING: ENSP00000259392

About this table

Gene Ontology (GO): Selected biological process terms (see all 29): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	--
GO:0001570	vasculogenesis	IMP	16964401
GO:0001666	response to hypoxia	IEA	--
GO:0002040	sprouting angiogenesis	ISS	--
GO:0006171	cAMP biosynthetic process	IDA	--

RAMP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for RAMP2 available from Tocris Bioscience About this table

Compound	Action	CAS #
AC 187	Potent and selective amylin receptor antagonist	[151804-77-2]
CGRP 8-37 (rat)	CGRP1 receptor antagonist	[129121-73-9]
CGRP 8-37 (human)	CGRP1 receptor antagonist	[119911-68-1]
BIBN 4096	Potent and selective CGRP receptor antagonist	[204697-65-4]
alpha-CGRP (human)	CGRP receptor agonist	[90954-53-3]

1 DrugBank Compound for RAMP2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pramlintide	--	151126-32-8	target	agonist	19273748 15494035 17139284 18593822 17016423 20015292

3 Novoseek inferred chemical compound relationships for RAMP2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	87.4	1	12183333 (1)
adenylate	19.4	1	14631146 (1)
dexamethasone	0	6	10772950 (3), 15358098 (1)

RAMP2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for RAMP2 gene:

NM_005854.2

Unigene Cluster for RAMP2:

Receptor (G protein-coupled) activity modifying protein 2

Hs.514193 [show with all ESTs]

Unigene Representative Sequence: BX420269

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000591972 ENST00000589683 ENST00000588928 ENST00000253796(uc002ibg.3 uc010cyt.3 uc021txv.1)

ENST00000587142 ENST00000588576

miRNA Products:		Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate RAMP2
		SwitchGear 3'UTR luciferase reporter plasmid: RAMP2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RAMP2
		Predesigned siRNA for gene silencing in human, mouse, rat RAMP2

Clone Products:		OriGene clones in human, mouse for RAMP2 (see all 7) OriGene ORF clones in mouse, rat for RAMP2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAMP2 (NM_005854)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2

Primer Products:		OriGene qPCR primer pairs and template standards for RAMP2 OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RAMP2
		QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
		QuantiFast Probe-based Assays in human, mouse, rat RAMP2

Additional mRNA sequence:

AJ001015.1 AY265458.1 BC027975.1 EF687002.1

3 DOTS entries:

DT.312550 DT.95270519 DT.100777069

Selected AceView cDNA sequences (see all 52):

BC027975 BX280360 BQ186604 CR590147 BG997107 AI832299 AA506528 CR621805

AY265458 AI221727 N91571 AA622338 AA367431 AA865325 AL548945 N89639

CA394804 BI837130 AA778001 BQ184629 BX420269 T96173 AI001908 AV727009

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

RAMP2 expression in normal human tissues (normalized intensities) RAMP2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCACAAGTTC

About this image

RAMP2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Heart (Cardiovascular System) fully expand to see all 4 entries
Primitive Heart Tube Cells Primitive Heart Tube
Heart Tube

Brain (Nervous System) fully expand to see all 2 entries
Adult Oligodendrocyte Precursor Cells Lateral Ventricle
Meninges

RAMP2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RAMP2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.514193

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895

Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues

Custom PCR Arrays for RAMP2

Primer Products:		OriGene qPCR primer pairs and template standards for RAMP2 OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RAMP2
		QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
		QuantiFast Probe-based Assays in human, mouse, rat RAMP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 gene from Selected species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ramp2^{1 , 5}	receptor (calcitonin) activity modifying protein 2^{1, 5}	75.29(n)¹ 68.39(a)¹		11 (64.47 cM)⁵ 54409¹ NM_019444.2¹ NP_062317.1¹ 101246028⁵
chicken (Gallus gallus)	Aves	RAMP2¹	receptor (G protein-coupled) activity modifying protein more	62.28(n) 53.51(a)		420022 NM_001105610.1 NP_001099080.1
lizard (Anolis carolinensis)	Reptilia	RAMP2⁶	receptor (G protein-coupled) activity modifying pr...	50(a)	1 ↔ 1	6(62018951-62021771)
zebrafish (Danio rerio)	Actinopterygii	ramp2⁶	receptor (G protein-coupled) activity modifying pr...	19(a)	1 ↔ 1	3(36831493-36841278) ENSDARG00000037895

ENSEMBL Gene Tree for RAMP2 (if available)
TreeFam Gene Tree for RAMP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for RAMP2 gene

RAMP3² RAMP1²

2 SIMAP similar genes for RAMP2 using alignment to 6 protein entries: RAMP2_HUMAN (see all proteins):

RAMP1 RAMP3

RAMP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74965130^1,2	F	--	40915503(+)	`TCACAA/GTTGAG`	1	--	ds500¹		1		NA	120
rs9893425^1,2	C,F,H	--	40915557(+)	`CTCCAT/CGTCCC`	1	--	ds500¹		8		NS NA WA	914
rs368372337^1,2	--	--	40915288(+)	`AGAGAA/CCCCTT`	1	--	ds500¹		0	--	--	--	--
rs372416317^1,2	--	--	40915517(+)	`GAAAGA/CGTGGG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAMP2 (40910465 - 40915059 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RAMP2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv833450	CNV	Loss	17160897
nsv908257	CNV	Loss	21882294
esv33998	OTHER	Inversion	15654335

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RAMP2

DNA2.0 Custom Variant and Variant Library Synthesis for RAMP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 605154 OMIM disorders: --

Selected diseases for RAMP2 (see all 21): About MalaCards

acute closed-angle glaucoma chorioamnionitis pheochromocytoma sepsis

hypoxia thyroiditis essential hypertension glaucoma

hypertension meningitis neuroblastoma endotheliitis

myocardial infarction pancreatic cancer cerebritis rheumatoid arthritis

arthritis lung cancer pancreatitis hepatitis

1 disease from the University of Copenhagen DISEASES database for RAMP2:

Acute closed-angle glaucoma

RAMP2 for disorders About GeneDecksing

8 Novoseek inferred disease relationships for RAMP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	46.1	1	17102095 (1)
glioblastoma	22.2	2	11943713 (1)
neovascularization	21.3	1	18097473 (1)
cardiovascular diseases	0	1	18198792 (1)
sepsis	0	1	11754970 (1)
glioma	0	1	11943713 (1)
tumors	0	5	17671114 (1), 19610056 (1)
heart failure	0	4	15300632 (2)

Genetic Association Database (GAD): RAMP2
Human Genome Epidemiology (HuGE) Navigator: RAMP2 (5 documents)

Export disorders for RAMP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RAMP2 gene, integrated from 10 sources (see all 125):
(articles sorted by number of sources associating them with RAMP2)

Utopia: connect your pdf to the dynamic
world of online information

Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PubMed id 19210874)^{1, 4, 9} Michou L....LiotAc F. (Clin. Exp. Rheumatol. 2008)
Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PubMed id 18593822)^{1, 7, 9} Qi T....Hay D.L. (Mol. Pharmacol. 2008)
Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PubMed id 22102369)^{1, 2} Kusano S.... Yokoyama S. (Protein Sci. 2012)
Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PubMed id 9620797)^{1, 2} McLatchie L.M.... Foord S.M. (Nature 1998)
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. (PubMed id 17671114)^{1, 9} Yue W....Zhang L. (Clin. Cancer Res. 2007)
Gene silencing of human RAMP2 mediated by short-interfering RNA. (PubMed id 16964401)^{1, 9} Albertin G....Nussdorfer G.G. (Int. J. Mol. Med. 2006)
The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PubMed id 18097473)^{1, 9} Ichikawa-Shindo Y....Shindo T. (J. Clin. Invest. 2008)
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PubMed id 20074556)^{1, 9} Kuwasako K....Kato J. (Biochem. Biophys. Res. Commun. 2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 10266	HGNC: 9844	AceView: RAMP2	Ensembl:ENSG00000131477	euGenes: HUgn10266
ECgene: RAMP2	Kegg: 10266	H-InvDB: RAMP2

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for RAMP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAMP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for RAMP2 gene:
Search GeneIP for patents involving RAMP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Antibodies for RAMP2 (RAMP2)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for RAMP2		OriGene RNAi products in human, mouse, rat for RAMP2
	OriGene qPCR primer pairs and template standards for RAMP2		OriGene Protein Over-expression Lysate for RAMP2
	OriGene Custom Mass Spec		OriGene clones in human, mouse for RAMP2
	OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for RAMP2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RAMP2		OriGene Custom Protein Services for RAMP2

	Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing RAMP2
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAMP2		Predesigned siRNA for gene silencing in human, mouse, rat RAMP2
	QuantiFast Probe-based Assays in human, mouse, rat RAMP2		QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
	Custom PCR Arrays for RAMP2		Search Chromatin IP Primers for RAMP2
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat RAMP2		GeneGlobe Interaction Network for RAMP2
	Regulatory tfbs in RAMP2 promoter

	GenScript Custom Purified and Recombinant Proteins Services for RAMP2		GenScript cDNA clones with any tag delivered in your preferred vector for RAMP2
	GenScript Custom Assay Services for RAMP2		GenScript Custom overexpressing Cell Line Services for RAMP2
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Tocris compounds for RAMP2

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RAMP2 antibodies
	RAMP2 proteins
	RAMP2 lysates

	Antibodies for RAMP2
	See all of Abcam's Antibodies, Kits and Proteins for RAMP2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Proteins for RAMP2
	Antibodies for RAMP2
	ELISAs for RAMP2
	CLIAs for RAMP2

Browse ESI BIO Cell Lines and PureStem Progenitors for RAMP2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2

	SwitchGear 3'UTR luciferase reporter plasmids for RAMP2
	SwitchGear Promoter luciferase reporter plasmids for RAMP2

ThermoFisher Antibodies for RAMP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAMP2
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAMP2

LSBio Antibodies in human, mouse, rat for RAMP2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RAMP2 gene at Home site.

Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

RAMP2 Gene

Receptor (G Protein-Coupled) Activity Modifying Protein...

Aliases
for RAMP2 gene

Summaries
for RAMP2 gene

Genomic Views
for RAMP2 gene

Proteins
for RAMP2 gene

RAMP2 Human Recombinant Protein Products:

RAMP2 Antibody Products:

RAMP2 Assay Products:

Domains /
Families
for RAMP2 gene

Function
for RAMP2 gene

Localization
for RAMP2 gene

Pathways & Interactions
for RAMP2 gene

Drugs & Compounds
for RAMP2 gene

Transcripts
for RAMP2 gene

Expression
for RAMP2 gene

Orthologs
for RAMP2 gene

Paralogs
for RAMP2 gene

Genomic Variants
for RAMP2 gene

Disorders / Diseases
for RAMP2 gene

Publications
for RAMP2 gene

External Searches for RAMP2 gene

Genome Databases showing RAMP2 gene

Other Databases showing RAMP2 gene

Specialized Databases showing RAMP2 gene

Intellectual Property
for RAMP2 gene

Products
for RAMP2 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

RAMP2 Gene

Receptor (G Protein-Coupled) Activity Modifying Protein...

Aliasesfor RAMP2 gene

Summariesfor RAMP2 gene

Genomic Viewsfor RAMP2 gene

Proteinsfor RAMP2 gene

RAMP2 Human Recombinant Protein Products:

RAMP2 Antibody Products:

RAMP2 Assay Products:

Domains /Familiesfor RAMP2 gene

Functionfor RAMP2 gene

Localizationfor RAMP2 gene

Pathways & Interactionsfor RAMP2 gene

Drugs & Compoundsfor RAMP2 gene

Transcriptsfor RAMP2 gene

Expression for RAMP2 gene

Orthologsfor RAMP2 gene

Paralogsfor RAMP2 gene

Genomic Variantsfor RAMP2 gene

Disorders / Diseasesfor RAMP2 gene

Publicationsfor RAMP2 gene

External Searches for RAMP2 gene

Genome Databases showing RAMP2 gene

Other Databases showing RAMP2 gene

Specialized Databases showing RAMP2 gene

Intellectual Propertyfor RAMP2 gene

Productsfor RAMP2 gene

View Random Gene

Aliases
for RAMP2 gene

Summaries
for RAMP2 gene

Genomic Views
for RAMP2 gene

Proteins
for RAMP2 gene

Domains /
Families
for RAMP2 gene

Function
for RAMP2 gene

Localization
for RAMP2 gene

Pathways & Interactions
for RAMP2 gene

Drugs & Compounds
for RAMP2 gene

Transcripts
for RAMP2 gene

Expression
for RAMP2 gene

Orthologs
for RAMP2 gene

Paralogs
for RAMP2 gene

Genomic Variants
for RAMP2 gene

Disorders / Diseases
for RAMP2 gene

Publications
for RAMP2 gene

Intellectual Property
for RAMP2 gene

Products
for RAMP2 gene