Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAMP2 Gene

protein-coding   GIFtS: 62
GCID: GC17P040913

Receptor (G Protein-Coupled) Activity Modifying Protein...

(Previous names: receptor activity modifying protein 2, receptor (calcitonin)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Receptor (G Protein-Coupled) Activity Modifying Protein 21 2     CRLR Activity-Modifying Protein 22 3
Receptor (Calcitonin) Activity Modifying Protein 21 2     Calcitonin Receptor-Like Receptor Activity Modifying Protein 22
Receptor Activity Modifying Protein 21 2     Receptor Activity-Modifying Protein 22
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 22 3     Receptor-Activity-Modifying Protein 22

External Ids:    HGNC: 98441   Entrez Gene: 102662   Ensembl: ENSG000001314777   OMIM: 6051545   UniProtKB: O608953   

Export aliases for RAMP2 gene to outside databases

Previous GC identifers: GC17P040484 GC17P043075 GC17P040821 GC17P041286 GC17P038166 GC17P036678


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAMP2 Gene:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called
receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an
extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like
receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either
a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of
the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin
receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to
the cell surface. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAMP2 Gene:
RAMP2 (receptor (G protein-coupled) activity modifying protein 2) is a protein-coding gene. Diseases associated with RAMP2 include acute closed-angle glaucoma, and chorioamnionitis. GO annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP3.

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895
Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as
a receptor for adrenomedullin (AM) together with CALCRL

summary for RAMP2 Gene:
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight
subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;
high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels
present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit
bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT
receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II
diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form
the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main
function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAMP2 gene promoter:
         STAT5B   MAZR   AP-4   CUTL1   LCR-F1   PPAR-gamma1   FOXJ2 (long isoform)   PPAR-gamma2   FOXJ2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAMP2 promoter sequence
   Search Chromatin IP Primers for RAMP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAMP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21.1   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q12-q21.1

RAMP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAMP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040913:  view genomic region     (about GC identifiers)

Start:
40,910,465 bp from pter      End:
40,915,059 bp from pter
Size:
4,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895 (See protein sequence)
Recommended Name: Receptor activity-modifying protein 2 precursor  
Size: 175 amino acids; 19608 Da
Subunit: Heterodimer of CALCRL and RAMP2 (By similarity)
3 PDB 3D structures from and Proteopedia for RAMP2:
2XVT (3D)        3AQE (3D)        3AQF (3D)    
Secondary accessions: Q8N1F2

Explore the universe of human proteins at neXtProt for RAMP2: NX_O60895

Explore proteomics data for RAMP2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn130
  • Modification sites at PhosphoSitePlus

  • See RAMP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005845.2  
    ENSEMBL proteins: 
     ENSP00000467463   ENSP00000466980   ENSP00000253796   ENSP00000466455   ENSP00000465725  
    Reactome Protein details: O60895

    RAMP2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RAMP2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RAMP2
    GenScript Custom Purified and Recombinant Proteins Services for RAMP2
    Novus Biologicals RAMP2 Proteins
    Novus Biologicals RAMP2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAMP2

    RAMP2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RAMP2
    OriGene Antibodies for RAMP2
    OriGene Custom Antibody Services for RAMP2
    Novus Biologicals RAMP2 Antibodies
    Abcam antibodies for RAMP2
    Cloud-Clone Corp. Antibodies for RAMP2
    ThermoFisher Antibodies for RAMP2
    LSBio Antibodies in human, mouse, rat for RAMP2

    RAMP2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAMP2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAMP2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAMP2
    Cloud-Clone Corp. CLIAs for RAMP2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RAMP: Receptor (G protein-coupled) activity modifying proteins

    IUPHAR Guide to PHARMACOLOGY protein family classification: RAMP2


    1 InterPro protein domain:
     IPR006985 RAMP

    Graphical View of Domain Structure for InterPro Entry O60895

    ProtoNet protein and cluster: O60895

    1 Blocks protein domain: IPB006985 Receptor activity modifying protein

    UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895
    Similarity: Belongs to the RAMP family


    RAMP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAMP2_HUMAN, O60895
    Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as
    a receptor for adrenomedullin (AM) together with CALCRL

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008565protein transporter activity IDA10882736
    GO:0015026coreceptor activity ISS--
         
    RAMP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAMP2:
     Increased cell number in S 

         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ramp2):
     cardiovascular system  embryogenesis  homeostasis/metabolism  immune system  integument 
     liver/biliary system  mortality/aging  muscle  nervous system  no phenotypic analysis 
     reproductive system 

    RAMP2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RAMP2: Ramp2tm1.1Tash Ramp2tm1Kmca

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAMP2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAMP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAMP2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAMP2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RAMP2
    SwitchGear 3'UTR luciferase reporter plasmidRAMP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAMP2
    Predesigned siRNA for gene silencing in human, mouse, rat RAMP2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAMP2

    Clone
    Products:
         
    OriGene clones in human, mouse for RAMP2 (see all 7)
    OriGene ORF clones in mouse, rat for RAMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAMP2 (NM_005854)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAMP2
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAMP2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RAMP2_HUMAN, O60895: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome4
    plasma membrane4
    vacuole4
    cytosol2
    mitochondrion2
    cytoskeleton1
    extracellular1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10882736
    GO:0005764lysosome TAS10882736
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9620797
    GO:0005905coated pit TAS10882736

    RAMP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAMP2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2ADP signalling through P2Y purinoceptor 12
    Class B/2 (Secretin family receptors)0.36
    Calcitonin-like ligand receptors0.00
    3Peptide ligand-binding receptors
    GPCR ligand binding0.71
    4Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43
    5Oxytocin signaling pathway
    Vascular smooth muscle contraction0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for RAMP2
        Myometrial Relaxation and Contraction Pathways

    2 Reactome Pathways for RAMP2
        Calcitonin-like ligand receptors
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for RAMP2):
        Vascular smooth muscle contraction


    RAMP2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAMP2
    Interactions:

        GeneGlobe Interaction Network for RAMP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for RAMP2 (O608953 ENSP000002537964) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCAP012583, ENSP000003317464I2D: score=1 STRING: ENSP00000331746
    CALCRLQ166023, ENSP000003761774I2D: score=1 STRING: ENSP00000376177
    IAPPP109973, ENSP000002406524I2D: score=2 STRING: ENSP00000240652
    VIPR1P322413, ENSP000003272464I2D: score=1 STRING: ENSP00000327246
    SLC31A2O154323, ENSP000002593924I2D: score=1 STRING: ENSP00000259392
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 29):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0001570vasculogenesis IMP16964401
    GO:0001666response to hypoxia IEA--
    GO:0002040sprouting angiogenesis ISS--
    GO:0006171cAMP biosynthetic process IDA--

    RAMP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for RAMP2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    1 DrugBank Compound for RAMP2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pramlintide-- 151126-32-8targetagonist19273748 15494035 17139284 18593822 17016423 20015292

    3 Novoseek inferred chemical compound relationships for RAMP2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 87.4 1 12183333 (1)
    adenylate 19.4 1 14631146 (1)
    dexamethasone 0 6 10772950 (3), 15358098 (1)



    RAMP2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAMP2 gene: 
    NM_005854.2  

    Unigene Cluster for RAMP2:

    Receptor (G protein-coupled) activity modifying protein 2
    Hs.514193  [show with all ESTs]
    Unigene Representative Sequence: BX420269
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591972 ENST00000589683 ENST00000588928 ENST00000253796(uc002ibg.3 uc010cyt.3 uc021txv.1)
    ENST00000587142 ENST00000588576
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RAMP2
    SwitchGear 3'UTR luciferase reporter plasmidRAMP2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAMP2
    Predesigned siRNA for gene silencing in human, mouse, rat RAMP2
    Clone
    Products:
         
    OriGene clones in human, mouse for RAMP2 (see all 7)
    OriGene ORF clones in mouse, rat for RAMP2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAMP2 (NM_005854)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RAMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAMP2
      QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
      QuantiFast Probe-based Assays in human, mouse, rat RAMP2

    Additional mRNA sequence: 

    AJ001015.1 AY265458.1 BC027975.1 EF687002.1 

    3 DOTS entries:

    DT.312550  DT.95270519  DT.100777069 

    Selected AceView cDNA sequences (see all 52):

    BC027975 BX280360 BQ186604 CR590147 BG997107 AI832299 AA506528 CR621805 
    AY265458 AI221727 N91571 AA622338 AA367431 AA865325 AL548945 N89639 
    CA394804 BI837130 AA778001 BQ184629 BX420269 T96173 AI001908 AV727009 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAMP2 expression in normal human tissues (normalized intensities)      RAMP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCACAAGTTC
    RAMP2 Expression
    About this image


    RAMP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             Heart Tube
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
             Meninges
    RAMP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAMP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514193

    UniProtKB/Swiss-Prot: RAMP2_HUMAN, O60895
    Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues

        Custom PCR Arrays for RAMP2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RAMP2
    OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAMP2
    QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
    QuantiFast Probe-based Assays in human, mouse, rat RAMP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for RAMP2 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ramp21 , 5 receptor (calcitonin) activity modifying protein 21, 5 75.29(n)1
    68.39(a)1
      11 (64.47 cM)5
    544091  NM_019444.21  NP_062317.11 
     1012460285 
    chicken
    (Gallus gallus)
    Aves RAMP21 receptor (G protein-coupled) activity modifying protein more 62.28(n)
    53.51(a)
      420022  NM_001105610.1  NP_001099080.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAMP26
    receptor (G protein-coupled) activity modifying pr...
    50(a)
    1 ↔ 1
    6(62018951-62021771)
    zebrafish
    (Danio rerio)
    Actinopterygii ramp26
    receptor (G protein-coupled) activity modifying pr...
    19(a)
    1 ↔ 1
    3(36831493-36841278) ENSDARG00000037895


    ENSEMBL Gene Tree for RAMP2 (if available)
    TreeFam Gene Tree for RAMP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RAMP2 gene
    RAMP32  RAMP12  
    2 SIMAP similar genes for RAMP2 using alignment to 6 protein entries:     RAMP2_HUMAN (see all proteins):
    RAMP1    RAMP3

    RAMP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    4 SNPs for RAMP2    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749651301,2
    F--40915503(+) TCACAA/GTTGAG 1 -- ds50011Minor allele frequency- G:0.02NA 120
    rs98934251,2
    C,F,H--40915557(+) CTCCAT/CGTCCC 1 -- ds50018Minor allele frequency- C:0.04NS NA WA 914
    rs3683723371,2
    ----40915288(+) AGAGAA/CCCCTT 1 -- ds50010--------
    rs3724163171,2
    ----40915517(+) GAAAGA/CGTGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAMP2 (40910465 - 40915059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RAMP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833450CNV Loss17160897
    nsv908257CNV Loss21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAMP2
    DNA2.0 Custom Variant and Variant Library Synthesis for RAMP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605154    OMIM disorders: --

    Selected diseases for RAMP2 (see all 21):    About MalaCards
    acute closed-angle glaucoma    chorioamnionitis    pheochromocytoma    sepsis
    hypoxia    thyroiditis    essential hypertension    glaucoma
    hypertension    meningitis    neuroblastoma    endotheliitis
    myocardial infarction    pancreatic cancer    cerebritis    rheumatoid arthritis
    arthritis    lung cancer    pancreatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for RAMP2:
    Acute closed-angle glaucoma

    RAMP2 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for RAMP2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pheochromocytoma 46.1 1 17102095 (1)
    glioblastoma 22.2 2 11943713 (1)
    neovascularization 21.3 1 18097473 (1)
    cardiovascular diseases 0 1 18198792 (1)
    sepsis 0 1 11754970 (1)
    glioma 0 1 11943713 (1)
    tumors 0 5 17671114 (1), 19610056 (1)
    heart failure 0 4 15300632 (2)

    Genetic Association Database (GAD): RAMP2
    Human Genome Epidemiology (HuGE) Navigator: RAMP2 (5 documents)

    Export disorders for RAMP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAMP2 gene, integrated from 10 sources (see all 125):
    (articles sorted by number of sources associating them with RAMP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PubMed id 19210874)1, 4, 9 Michou L....LiotAc F. (Clin. Exp. Rheumatol. 2008)
    2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PubMed id 18593822)1, 7, 9 Qi T....Hay D.L. (Mol. Pharmacol. 2008)
    3. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PubMed id 22102369)1, 2 Kusano S.... Yokoyama S. (Protein Sci. 2012)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PubMed id 9620797)1, 2 McLatchie L.M.... Foord S.M. (Nature 1998)
    7. Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. (PubMed id 17671114)1, 9 Yue W....Zhang L. (Clin. Cancer Res. 2007)
    8. Gene silencing of human RAMP2 mediated by short-interfering RNA. (PubMed id 16964401)1, 9 Albertin G....Nussdorfer G.G. (Int. J. Mol. Med. 2006)
    9. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PubMed id 18097473)1, 9 Ichikawa-Shindo Y....Shindo T. (J. Clin. Invest. 2008)
    10. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PubMed id 20074556)1, 9 Kuwasako K....Kato J. (Biochem. Biophys. Res. Commun. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10266 HGNC: 9844 AceView: RAMP2 Ensembl:ENSG00000131477 euGenes: HUgn10266
    ECgene: RAMP2 Kegg: 10266 H-InvDB: RAMP2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAMP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAMP2 gene:
    Search GeneIP for patents involving RAMP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for RAMP2 (RAMP2)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAMP2   OriGene RNAi products in human, mouse, rat for RAMP2  
     OriGene qPCR primer pairs and template standards for RAMP2   OriGene Protein Over-expression Lysate for RAMP2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RAMP2  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAMP2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RAMP2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAMP2   OriGene Custom Protein Services for RAMP2  

     
     
     Block miRNA regulation of human, mouse, rat RAMP2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAMP2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAMP2 Predesigned siRNA for gene silencing in human, mouse, rat RAMP2
     QuantiFast Probe-based Assays in human, mouse, rat RAMP2 QuantiTect SYBR Green Assays in human, mouse, rat RAMP2
     Custom PCR Arrays for RAMP2 Search Chromatin IP Primers for RAMP2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAMP2  GeneGlobe Interaction Network for RAMP2
     Regulatory tfbs in RAMP2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAMP2 GenScript cDNA clones with any tag delivered in your preferred vector for RAMP2
     GenScript Custom Assay Services for RAMP2 GenScript Custom overexpressing Cell Line Services for RAMP2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for RAMP2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAMP2 antibodies
     RAMP2 proteins
     RAMP2 lysates
     Antibodies for RAMP2
     See all of Abcam's Antibodies, Kits and Proteins for RAMP2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RAMP2
     Antibodies for RAMP2
     ELISAs for RAMP2
     CLIAs for RAMP2



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAMP2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP2
     SwitchGear 3'UTR luciferase reporter plasmids for RAMP2
     SwitchGear Promoter luciferase reporter plasmids for RAMP2
     ThermoFisher Antibodies for RAMP2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAMP2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAMP2
     LSBio Antibodies in human, mouse, rat for RAMP2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAMP2 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4