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Aliases for RAMP2 Gene

Aliases for RAMP2 Gene

  • Receptor (G Protein-Coupled) Activity Modifying Protein 2 2 3
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 4
  • Receptor (Calcitonin) Activity Modifying Protein 2 2
  • Receptor Activity Modifying Protein 2 2
  • CRLR Activity-Modifying Protein 2 4

External Ids for RAMP2 Gene

Previous GeneCards Identifiers for RAMP2 Gene

  • GC17P040484
  • GC17P043075
  • GC17P040821
  • GC17P041286
  • GC17P038166
  • GC17P040913
  • GC17P036678

Summaries for RAMP2 Gene

Entrez Gene Summary for RAMP2 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP2 Gene

RAMP2 (Receptor (G Protein-Coupled) Activity Modifying Protein 2) is a Protein Coding gene. Diseases associated with RAMP2 include acute closed-angle glaucoma and pheochromocytoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include protein transporter activity and coreceptor activity. An important paralog of this gene is RAMP1.

UniProtKB/Swiss-Prot for RAMP2 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Tocris Summary for RAMP2 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP2 Gene

Genomics for RAMP2 Gene

Regulatory Elements for RAMP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAMP2 Gene

42,758,447 bp from pter
42,763,041 bp from pter
4,595 bases
Plus strand

Genomic View for RAMP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAMP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP2 Gene

Proteins for RAMP2 Gene

  • Protein details for RAMP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor activity-modifying protein 2
    Protein Accession:
    Secondary Accessions:
    • A7L9S6
    • K7EMD3
    • Q8N1F2

    Protein attributes for RAMP2 Gene

    175 amino acids
    Molecular mass:
    19608 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP2.

    Three dimensional structures from OCA and Proteopedia for RAMP2 Gene

    Alternative splice isoforms for RAMP2 Gene


neXtProt entry for RAMP2 Gene

Proteomics data for RAMP2 Gene at MOPED

Post-translational modifications for RAMP2 Gene

  • Glycosylation at Asn130
  • Modification sites at PhosphoSitePlus

Other Protein References for RAMP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAMP2 Gene

Domains for RAMP2 Gene

Protein Domains for RAMP2 Gene


Suggested Antigen Peptide Sequences for RAMP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RAMP family.
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP2: view

Function for RAMP2 Gene

Molecular function for RAMP2 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20596610
GO:0008565 protein transporter activity IDA 10882736
GO:0015026 coreceptor activity ISS --
genes like me logo Genes that share ontologies with RAMP2: view
genes like me logo Genes that share phenotypes with RAMP2: view

Animal Models for RAMP2 Gene

MGI Knock Outs for RAMP2:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for RAMP2 Gene

Localization for RAMP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for RAMP2 Gene COMPARTMENTS Subcellular localization image for RAMP2 gene
Compartment Confidence
lysosome 4
plasma membrane 4
vacuole 4
cytosol 2
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 10882736
GO:0005764 lysosome TAS 10882736
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0005905 coated pit TAS 10882736
genes like me logo Genes that share ontologies with RAMP2: view

Pathways for RAMP2 Gene

genes like me logo Genes that share pathways with RAMP2: view

Pathways by source for RAMP2 Gene

Gene Ontology (GO) - Biological Process for RAMP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0001570 vasculogenesis IMP 16964401
GO:0001666 response to hypoxia IEA --
GO:0002040 sprouting angiogenesis ISS --
GO:0006171 cAMP biosynthetic process IDA 20074556
genes like me logo Genes that share ontologies with RAMP2: view

Drugs for RAMP2 Gene

(1) Drugbank Compounds for RAMP2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
151126-32-8 Target agonist approved, investigational

(5) Tocris Compounds for RAMP2 Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(3) Novoseek inferred chemical compound relationships for RAMP2 Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 87.4 1
adenylate 19.4 1
dexamethasone 0 4
genes like me logo Genes that share compounds with RAMP2: view

Transcripts for RAMP2 Gene

Unigene Clusters for RAMP2 Gene

Receptor (G protein-coupled) activity modifying protein 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP2 Gene

No ASD Table

Relevant External Links for RAMP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAMP2 Gene

mRNA expression in normal human tissues for RAMP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (4.1).

Protein differential expression in normal tissues for RAMP2 Gene

This gene is overexpressed in Fetal gut (58.3) and Fetal heart (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAMP2 Gene

SOURCE GeneReport for Unigene cluster for RAMP2 Gene Hs.514193

mRNA Expression by UniProt/SwissProt for RAMP2 Gene

Tissue specificity: Strongly expressed in lung, breast, immune system and fetal tissues.
genes like me logo Genes that share expressions with RAMP2: view

Expression partners for RAMP2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for RAMP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAMP2 35
  • 83.72 (n)
  • 78.74 (a)
RAMP2 36
  • 62 (a)
(Canis familiaris)
Mammalia RAMP2 35
  • 84.95 (n)
  • 80 (a)
-- 36
  • 63 (a)
-- 36
  • 67 (a)
(Mus musculus)
Mammalia Ramp2 35
  • 75.29 (n)
  • 68.39 (a)
Ramp2 16
Ramp2 36
  • 50 (a)
(Pan troglodytes)
Mammalia RAMP2 35
  • 97.71 (n)
  • 96.55 (a)
RAMP2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ramp2 35
  • 77.26 (n)
  • 68.79 (a)
(Monodelphis domestica)
Mammalia RAMP2 36
  • 45 (a)
(Gallus gallus)
Aves RAMP2 35
  • 62.28 (n)
  • 53.51 (a)
RAMP2 36
  • 39 (a)
(Anolis carolinensis)
Reptilia RAMP2 36
  • 50 (a)
(Danio rerio)
Actinopterygii ramp2 36
  • 19 (a)
Species with no ortholog for RAMP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP2 Gene

Gene Tree for RAMP2 (if available)
Gene Tree for RAMP2 (if available)

Paralogs for RAMP2 Gene

Paralogs for RAMP2 Gene

(2) SIMAP similar genes for RAMP2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAMP2: view

Variants for RAMP2 Gene

Sequence variations from dbSNP and Humsavar for RAMP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs577503167 -- 42,763,336(+) AAGGG(A/T)GGAAT downstream-variant-500B
rs573264291 -- 42,763,466(+) GAATC(C/T)ATTCC downstream-variant-500B
rs571945888 -- 42,763,471(+) ATTCC(-/CTT)TAAGG downstream-variant-500B
rs564456542 -- 42,763,412(+) CATGC(A/T)TCAGT downstream-variant-500B
rs556072778 -- 42,763,314(+) GGGGA(C/G)GTGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAMP2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv833450 CNV Loss 17160897
nsv908257 CNV Loss 21882294

Relevant External Links for RAMP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP2 Gene

Disorders for RAMP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for RAMP2 Gene in MalaCards »

(2) Diseases for RAMP2 Gene

(1) University of Copenhagen DISEASES for RAMP2 Gene

(8) Novoseek inferred disease relationships for RAMP2 Gene

Disease -log(P) Hits PubMed IDs
pheochromocytoma 46.1 1
glioblastoma 22.2 1
neovascularization 21.3 1
cardiovascular diseases 0 1
sepsis 0 1

Relevant External Links for RAMP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAMP2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for RAMP2 Gene

Publications for RAMP2 Gene

  1. Lack of linkage and association of adrenomedullin and its receptor genes in French Caucasian rheumatoid arthritis trio families. (PMID: 19210874) Michou L. … LiotAc F. (Clin. Exp. Rheumatol. 2008) 3 23 48
  2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  3. Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding. (PMID: 22102369) Kusano S. … Yokoyama S. (Protein Sci. 2012) 3 4
  4. Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2. (PMID: 20074556) Kuwasako K. … Kato J. (Biochem. Biophys. Res. Commun. 2010) 3 23
  5. The GPCR modulator protein RAMP2 is essential for angiogenesis and vascular integrity. (PMID: 18097473) Ichikawa-Shindo Y. … Shindo T. (J. Clin. Invest. 2008) 3 23

Products for RAMP2 Gene

  • Addgene plasmids for RAMP2

Sources for RAMP2 Gene

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