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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAMP1 Gene

protein-coding   GIFtS: 62
GCID: GC02P238767

Receptor (G Protein-Coupled) Activity Modifying Protein...

(Previous names: receptor activity modifying protein 1, receptor (calcitonin)...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Receptor (G Protein-Coupled) Activity Modifying Protein 11 2     CRLR Activity-Modifying Protein 12 3
Receptor (Calcitonin) Activity Modifying Protein 11 2     Calcitonin Receptor-Like Receptor Activity Modifying Protein 12
Receptor Activity Modifying Protein 11 2     Receptor Activity-Modifying Protein 12
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 12 3     

External Ids:    HGNC: 98431   Entrez Gene: 102672   Ensembl: ENSG000001323297   OMIM: 6051535   UniProtKB: O608943   

Export aliases for RAMP1 gene to outside databases

Previous GC identifers: GC02P236817 GC02P237449 GC02P238783 GC02P239055 GC02P238550 GC02P238432 GC02P230560


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAMP1 Gene:
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called
receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an
extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like
receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either
a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of
the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The
RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the
cell surface. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAMP1 Gene: 
RAMP1 (receptor (G protein-coupled) activity modifying protein 1) is a protein-coding gene. Diseases associated with RAMP1 include migraine, and cerebral infarction, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP2.

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894
Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as
a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL

summary for RAMP1 Gene:
Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight
subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;
high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels
present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit
bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT
receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II
diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form
the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main
function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005120.16  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAMP1 gene promoter:
         Lmo2   FOXO3   AP-4   FOXO3b   FAC1   Nkx6-1   FOXC1   GATA-6   FOXO3a   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAMP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAMP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAMP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36-q37.1   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q36-q37.1

RAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAMP1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238767:  view genomic region     (about GC identifiers)

Start:
238,767,536 bp from pter      End:
238,820,756 bp from pter
Size:
53,221 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894 (See protein sequence)
Recommended Name: Receptor activity-modifying protein 1 precursor  
Size: 148 amino acids; 16988 Da
Subunit: Heterodimer of CALCRL and RAMP1
Subcellular location: Membrane; Single-pass type I membrane protein
4 PDB 3D structures from and Proteopedia for RAMP1:
2YX8 (3D)        3N7P (3D)        3N7R (3D)        3N7S (3D)    
Secondary accessions: Q6FGS5

Explore the universe of human proteins at neXtProt for RAMP1: NX_O60894

Explore proteomics data for RAMP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60894

  • RAMP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAMP1 Protein Expression
    REFSEQ proteins: NP_005846.1  
    ENSEMBL proteins: 
     ENSP00000384688   ENSP00000254661   ENSP00000386720   ENSP00000386046  
    Reactome Protein details: O60894
    Human Recombinant Protein Products for RAMP1: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAMP1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9620797
    GO:0009986cell surface IDA14722252
    GO:0016021integral to membrane ----

    RAMP1 for ontologies           About GeneDecksing



    RAMP1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RAMP: Receptor (G protein-coupled) activity modifying proteins

    IUPHAR Guide to PHARMACOLOGY protein family classification: RAMP1 


    1 InterPro protein domain:
     IPR006985 RAMP

    Graphical View of Domain Structure for InterPro Entry O60894

    ProtoNet protein and cluster: O60894

    1 Blocks protein domain: IPB006985 Receptor activity modifying protein

    UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894
    Similarity: Belongs to the RAMP family


    RAMP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAMP1_HUMAN, O60894
    Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as
    a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity IDA10882736
    GO:0004948calcitonin receptor activity IDA9620797
    GO:0005515protein binding IPI14722252
    GO:0008565protein transporter activity IDA10882736
    GO:0015026coreceptor activity IEA--
         
    RAMP1 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ramp1):
     cardiovascular system  homeostasis/metabolism  immune system  muscle  no phenotypic analysis 

    RAMP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ramp1tm1.1Tsuj for RAMP1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAMP1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAMP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAMP1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAMP1 

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RAMP1:
    hsa-miR-34b
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAMP1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    Class B/2 (Secretin family receptors)0.36
    G alpha (s) signalling events0.31
    3Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71
    4Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways0.43
    5Vascular smooth muscle contraction
    Vascular smooth muscle contraction

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for RAMP1
        Myometrial Relaxation and Contraction Pathways
    Endothelin


    5/7        Reactome Pathways for RAMP1 (see all 7)
        GPCR downstream signaling
    Signal Transduction
    Signaling by GPCR
    Calcitonin-like ligand receptors
    GPCR ligand binding


    1         Kegg Pathway  (Kegg details for RAMP1):
        Vascular smooth muscle contraction


    RAMP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAMP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/8 Interacting proteins for RAMP1 (O608943 ENSP000002546614) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCRLQ166023, ENSP000003761774I2D: score=3 STRING: ENSP00000376177
    CALCAP012583, ENSP000003317464I2D: score=1 STRING: ENSP00000331746
    CALCRP309883, ENSP000003525614I2D: score=1 STRING: ENSP00000352561
    IAPPP109973, ENSP000002406524I2D: score=1 STRING: ENSP00000240652
    VIPR1P322413, ENSP000003272464I2D: score=1 STRING: ENSP00000327246
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IDA--
    GO:0006816calcium ion transport IDA10882736
    GO:0006886intracellular protein transport IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0008277regulation of G-protein coupled receptor protein signaling pathway IDA9620797

    RAMP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAMP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for RAMP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    AC 187Potent and selective amylin receptor antagonist[151804-77-2]
    CGRP 8-37 (rat)CGRP1 receptor antagonist[129121-73-9]
    CGRP 8-37 (human)CGRP1 receptor antagonist[119911-68-1]
    BIBN 4096Potent and selective CGRP receptor antagonist[204697-65-4]
    alpha-CGRP (human)CGRP receptor agonist[90954-53-3]

    1 DrugBank Compound for RAMP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pramlintide-- 151126-32-8targetagonist19273748 15494035 17139284 18593822 17016423 11772274 20015292 20357016

    6 Novoseek inferred chemical compound relationships for RAMP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bibn 4096 bs 93.7 10 16959943 (4), 19914210 (3), 12183333 (2), 15494030 (1)
    alanine 31.5 5 19072332 (3), 20188075 (1), 16776831 (1)
    potassium 1.27 1 9877154 (1)
    lysine 0 1 17310067 (1)
    nitric oxide 0 1 19441274 (1)
    dexamethasone 0 10 10772950 (4), 15358098 (1)

    Search CenterWatch for drugs/clinical trials and news about RAMP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAMP1 gene: 
    NM_005855.2  

    Unigene Cluster for RAMP1:

    Receptor (G protein-coupled) activity modifying protein 1
    Hs.471783  [show with all ESTs]
    Unigene Representative Sequence: BG036385
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000404910 ENST00000254661(uc002vxj.3) ENST00000409726 ENST00000403885

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate RAMP1:
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    Additional mRNA sequence: 

    AJ001014.1 AY265457.1 BC000548.2 CR542032.1 CR542044.1 

    4 DOTS entries:

    DT.213716  DT.75135222  DT.100749710  DT.120709935 

    24/102 AceView cDNA sequences (see all 102):

    CK822019 AI370983 CF529943 BM978161 BF206141 BE382507 CR621253 AI244379 
    BG820924 CR542044 CA776338 AA587382 AI017108 BI760643 AY265457 NM_005855 
    BM795108 AJ001014 BQ071673 AI151032 BE383331 AI418029 AI884911 AJ346365 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RAMP1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                          
    SP2:        -     -                           
    SP3:              -                           


    ECgene alternative splicing isoforms for RAMP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAMP1 expression in normal human tissues (normalized intensities)      RAMP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGCTACTT
    RAMP1 Expression
    About this image


    RAMP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced 7PEND24 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 3 entries
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             granulocyte-monocyte progenitors   
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Uncategorized (Uncategorized)
             PureStem Progenitor ES-154

    See RAMP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAMP1

    SOURCE GeneReport for Unigene cluster: Hs.471783

    UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894
    Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal
    tract

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAMP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for RAMP1 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ramp11 , 5 receptor (calcitonin) activity modifying protein 11, 5 79.28(n)1
    70.95(a)1
      1 (46.08 cM)5
    518011  NM_016894.31  NP_058590.11 
     911798225 
    chicken
    (Gallus gallus)
    Aves RAMP16
    receptor (G protein-coupled) activity modifying pr...
    54(a)
    1 ↔ 1
    7(4591385-4595864)
    lizard
    (Anolis carolinensis)
    Reptilia RAMP16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    1(117305024-117333652)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:918181 zgc:91818 57.55(n)
    51.08(a)
      436966  NM_001002693.1  NP_001002693.1 


    ENSEMBL Gene Tree for RAMP1 (if available)
    TreeFam Gene Tree for RAMP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAMP1 gene
    RAMP22  RAMP32  
    2 SIMAP similar genes for RAMP1 using alignment to 4 protein entries:     RAMP1_HUMAN (see all proteins):
    RAMP3    RAMP2

    RAMP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1306 SNPs in RAMP1 are shown (see all 1306)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502433441,2
    --238766226(+) CTGTGA/CATTTC 1 -- us2k10--------
    rs1457933521,2
    C--238766364(+) AACGTC/TGGGAA 1 -- us2k10--------
    rs665957251,2
    C,F--238766407(+) GTCCCA/TGTTGC 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1836414761,2
    --238766409(+) CCCAGC/TTGCCA 1 -- us2k10--------
    rs1406673881,2
    --238766415(+) TGCCAA/GCCAAA 1 -- us2k10--------
    rs797519801,2
    C,F--238766547(+) CCATCG/ACCTAG 1 -- us2k12Minor allele frequency- A:0.14WA NA 238
    rs774531711,2
    F--238766564(+) ATGTAC/TGGTGG 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs1458743551,2
    --238766660(+) TGCTCA/GGGCCT 1 -- us2k10--------
    rs1891851091,2
    --238766752(+) CTTGCA/GCTGCA 1 -- us2k10--------
    rs37547041,2
    C,F,H--238766765(-) CACTCG/ACCTCA 1 -- us2k114Minor allele frequency- A:0.19EA NS NA WA 1818

    HapMap Linkage Disequilibrium report for RAMP1 (238767536 - 238820756 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RAMP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657266CNV Deletion23128226
    esv2661727CNV Deletion23128226
    nsv876061CNV Loss21882294
    nsv519581CNV Loss19592680
    esv274938CNV Loss21479260
    nsv527428CNV Loss19592680
    nsv508205CNV Loss20534489
    nsv516443CNV Gain+Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605153    OMIM disorders: --

    14 diseases for RAMP1:    About MalaCards
    migraine    cerebral infarction    pertussis    thyroiditis
    cerebritis    myocardial infarction    asthma    hypoxia
    pancreatic cancer    hypertension    endotheliitis    pancreatitis
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for RAMP1:
    Migraine

    RAMP1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RAMP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    migraine 43.9 3 17344407 (1), 18240900 (1)
    cardiovascular diseases 0 1 18198792 (1)
    heart failure 0 4 15300632 (2)

    Genetic Association Database (GAD): RAMP1
    Human Genome Epidemiology (HuGE) Navigator: RAMP1 (1 document)

    Export disorders for RAMP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAMP1 gene, integrated from 9 sources (see all 147):
    (articles sorted by number of sources associating them with RAMP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PubMed id 18593822)1, 7, 9 Qi T....Hay D.L. (2008)
    2. Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. (PubMed id 18725456)1, 2, 9 Kusano S....Yokoyama S. (2008)
    3. Haplotype-based case-control study of receptor (calci tonin) activity-modifying protein-1 gene in cerebral infarction. (PubMed id 19710695)1, 4, 9 Nakazato T....Doba N. (2009)
    4. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PubMed id 9620797)1, 2, 9 McLatchie L.M.... Foord S.M. (1998)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. (PubMed id 17310067)1, 9 Cottrell G.S....Bunnett N.W. (2007)
    7. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. (PubMed id 11847213)1, 9 Mallee J.J....Kane S.A. (2002)
    8. Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. (PubMed id 11535606)1, 9 Hilairet S....Bouvier M. (2001)
    9. Receptor activity-modifying protein 1 increases baror eflex sensitivity and attenuates Angiotensin-induced hypertension. (PubMed id 20100989)1, 9 Sabharwal R....Chapleau M.W. (2010)
    10. Mapping the CGRP receptor ligand binding domain: tryp tophan-84 of RAMP1 is critical for agonist and antagonist binding. (PubMed id 20188075)1, 9 Moore E.L....Salvatore C.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10267 HGNC: 9843 AceView: RAMP1 Ensembl:ENSG00000132329 euGenes: HUgn10267
    ECgene: RAMP1 Kegg: 10267 H-InvDB: RAMP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAMP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAMP1 gene:
    Search GeneIP for patents involving RAMP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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