Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAMP1 Gene

protein-coding GIFtS: 59
GCID: GC02P238767

receptor (G protein-coupled) activity modifying protein...

(Previous names: receptor activity modifying protein 1, receptor (calcitonin)...)

Explore 13 diseases affiliated with
RAMP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Receptor (G Protein-Coupled) Activity Modifying Protein 1¹ ²		CRLR Activity-Modifying Protein 1² ³
Receptor (Calcitonin) Activity Modifying Protein 1¹ ²		Calcitonin Receptor-Like Receptor Activity Modifying Protein 1²
Receptor Activity Modifying Protein 1¹ ²		Receptor Activity-Modifying Protein 1²
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1² ³

External Ids:	HGNC: 9843¹	Entrez Gene: 10267²	Ensembl: ENSG00000132329⁷	OMIM: 605153⁵	UniProtKB: O60894³

Export aliases for RAMP1 gene to outside databases

Previous GC identifers: GC02P236817 GC02P237449 GC02P238783 GC02P239055 GC02P238550 GC02P238432 GC02P230560

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAMP1:

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called

receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an

extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like

receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a

calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP

family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is

involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.

(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a

receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL

summary for RAMP1:

Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight

subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution;

high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels

present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit

bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT

receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II

diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form

the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main

function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005120.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAMP1 gene promoter:
Lmo2 FOXO3 AP-4 FOXO3b FAC1 Nkx6-1 FOXC1 GATA-6 FOXO3a MRF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAMP1 promoter sequence

Search SABiosciences Chromatin IP Primers for RAMP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAMP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36-q37.1 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q36-q37.1

RAMP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAMP1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P238767: view genomic region (about GC identifiers)

Start:	238,767,536 bp from pter	End:	238,820,756 bp from pter
Size:	53,221 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894 (See protein sequence)

Recommended Name: Receptor activity-modifying protein 1 precursor

Size: 148 amino acids; 16988 Da

Subunit: Heterodimer of CALCRL and RAMP1

Subcellular location: Membrane; Single-pass type I membrane protein

4 PDB 3D structures from and Proteopedia for RAMP1:

2YX8 (3D)

3N7P (3D)

3N7R (3D)

3N7S (3D)

Secondary accessions: Q6FGS5

Explore the universe of human proteins at neXtProt for RAMP1: NX_O60894

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60894

RAMP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005846.1

ENSEMBL proteins:

ENSP00000384688 ENSP00000254661 ENSP00000386720 ENSP00000386046

Reactome Protein details: O60894
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: RAMP1 OriGene Custom Protein Services for RAMP1
	GenScript Custom Purified and Recombinant Proteins Services for RAMP1
	Novus Biologicals RAMP1 Proteins Novus Biologicals RAMP1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RAMP1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9620797
GO:0009986	cell surface	IDA	14722252

RAMP1 for ontologies About GeneDecksing

RAMP1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for RAMP1
	OriGene Antibodies (see all 2): RAMP1 OriGene Custom Antibody Services for RAMP1
	GenScript Custom Superior Antibodies Services for RAMP1
	Novus Biologicals RAMP1 Antibodies
	Abcam antibodies for RAMP1
	Uscn Antibodies for RAMP1
	ThermoFisher Antibodies for RAMP1

Assay Products for RAMP1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RAMP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RAMP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAMP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR006985 RAMP

Graphical View of Domain Structure for InterPro Entry O60894

ProtoNet protein and cluster: O60894

1 Blocks protein family: IPB006985 Receptor activity modifying protein

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894

Similarity: Belongs to the RAMP family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894

Function: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a

receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL

miRNA Products:		OriGene 3'-UTR Clone: RAMP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAMP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RAMP1:
		hsa-miR-34b
		SwitchGear 3'UTR luciferase reporter plasmid: RAMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAMP1 (see all 7) OriGene shRNA RFP: RAMP1 OriGene siRNA: RAMP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAMP1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RAMP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAMP1 (NM_005855)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAMP1
		Search LifeMap BioReagents cell lines for RAMP1

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAMP1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IDA	14722252
GO:0004948	calcitonin receptor activity	IDA	9620797
GO:0005515	protein binding	IPI	14722252
GO:0008565	protein transporter activity	IDA	10882736
GO:0015026	coreceptor activity	IEA	--

RAMP1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Ramp1^tm1.1Tsuj for RAMP1
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ramp1):

cardiovascular system

homeostasis/metabolism

immune system

muscle

no phenotypic analysis

RAMP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

Class B/2 (Secretin family receptors)

0.20

G alpha (s) signalling events

0.14

Calcitonin-like ligand receptors

Calcitonin-like ligand receptors

1.00

Endothelin

Endothelin

1.00

Class A/1 (Rhodopsin-like receptors)

GPCR ligand binding

0.75

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for RAMP1

	Myometrial Relaxation and Contraction Pathways
	Endothelin

5/7 Reactome Pathways for RAMP1 (see all 7)

	GPCR downstream signaling
	Signal Transduction
	Signaling by GPCR
	Calcitonin-like ligand receptors
	GPCR ligand binding

1 Kegg Pathway (Kegg details for RAMP1):

Vascular smooth muscle contraction

RAMP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAMP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/8 Interacting proteins for RAMP1 (O60894³ ENSP00000254661⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALCRL	Q16602³, ENSP00000376177⁴	I2D: score=3 STRING: ENSP00000376177
CALCA	P01258³, ENSP00000331746⁴	I2D: score=1 STRING: ENSP00000331746
CALCR	P30988³, ENSP00000352561⁴	I2D: score=1 STRING: ENSP00000352561
IAPP	P10997³, ENSP00000240652⁴	I2D: score=1 STRING: ENSP00000240652
VIPR1	P32241³, ENSP00000327246⁴	I2D: score=1 STRING: ENSP00000327246

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	IDA	--
GO:0006816	calcium ion transport	IDA	10882736
GO:0006886	intracellular protein transport	IEA	--
GO:0007186	G-protein coupled receptor signaling pathway	--	--
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway	IDA	9620797

RAMP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RAMP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for RAMP1 available from Tocris Bioscience About this table

Compound	Action	CAS #
Amylin	Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors	[122384-88-7]
AC 187	Potent and selective amylin receptor antagonist	[151804-77-2]

1 DrugBank Compound for RAMP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Pramlintide	--	151126-32-8	target	agonist	19273748 15494035 17139284 18593822 17016423 11772274 20015292 20357016

6 Novoseek chemical compound relationships for RAMP1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
bibn 4096 bs	93.7	10	16959943 (4), 19914210 (3), 12183333 (2), 15494030 (1)
alanine	31.5	5	19072332 (3), 20188075 (1), 16776831 (1)
potassium	1.27	1	9877154 (1)
lysine	0	1	17310067 (1)
nitric oxide	0	1	19441274 (1)
dexamethasone	0	10	10772950 (4), 15358098 (1)

Search CenterWatch for drugs/clinical trials and news about RAMP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAMP1 gene:

NM_005855.2

Unigene Cluster for RAMP1:

Receptor (G protein-coupled) activity modifying protein 1

Hs.471783 [show with all ESTs]

Unigene Representative Sequence: BG036385

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000404910 ENST00000254661(uc002vxj.3) ENST00000409726 ENST00000403885

miRNA Products:		OriGene 3'-UTR Clone: RAMP1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAMP1
		1 QIAGEN miScript miRNA Assays for microRNA that regulate RAMP1:
		hsa-miR-34b
		SwitchGear 3'UTR luciferase reporter plasmid: RAMP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAMP1 (see all 7) OriGene shRNA RFP: RAMP1 OriGene siRNA: RAMP1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAMP1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RAMP1 (NM_005855)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAMP1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAMP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAMP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAMP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAMP1

Additional cDNA sequence:

AJ001014.1 AY265457.1 BC000548.2 CR542032.1 CR542044.1

4 DOTS entries:

DT.213716 DT.75135222 DT.100749710 DT.120709935

24/102 AceView cDNA sequences (see all 102):

BE382425 BE877621 CK822019 AI076879 BM974755 CR542032 BE383331 AI418029

BM795108 AJ346365 AI884911 BQ071673 AJ001014 AI151032 NM_005855 BF206141

BI760643 AY265457 CA776338 CR542044 AA587382 AI017108 BG820924 AI244379

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for RAMP1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c
SP1:
SP2:			-		-
SP3:					-

ECgene alternative splicing isoforms for RAMP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGCTACTT

About this image

RAMP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Postnatal Endothelial Cells

Blood Brain Barrier, Endothelium

Ovary

Antral Follicle

Cumulus Cells

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor T42 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

PureStem™ progenitor W8 (Embryonic Progenitor Cell)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See RAMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAMP1

SOURCE GeneReport for Unigene cluster: Hs.471783

UniProtKB/Swiss-Prot: RAMP1_HUMAN, O60894

Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal

tract

SABiosciences Custom PCR Arrays for RAMP1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAMP1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAMP1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAMP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAMP1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAMP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for RAMP1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RAMP1⁶	Uncharacterized protein	60(a)	1 ↔ 1	7(4627376-4637209)
lizard (Anolis carolinensis)	Reptilia	RAMP1⁶	--	56(a)	1 ↔ 1	1(117306613-117333652)
zebrafish (Danio rerio)	Actinopterygii	zgc:91818¹	zgc:91818	57.55(n) 51.08(a)		436966 NM_001002693.1 NP_001002693.1

ENSEMBL Gene Tree for RAMP1 (if available)
TreeFam Gene Tree for RAMP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAMP1 gene

RAMP2² RAMP3²

2 SIMAP similar genes for RAMP1 using alignment to 4 protein entries: RAMP1_HUMAN (see all proteins):

RAMP3 RAMP2

RAMP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150243344^1,2		--	238766226(+)	`CTGTGA/CATTTC`	1	--	us2k¹		0	--	--	--	--
rs145793352^1,2		--	238766364(+)	`AACGTC/TGGGAA`	1	--	us2k¹		0	--	--	--	--
rs66595725^1,2	C,	--	238766407(+)	`GTCCCA/TGTTGC`	1	--	us2k¹		2		WA	120
rs183641476^1,2		--	238766409(+)	`CCCAGC/TTGCCA`	1	--	us2k¹		0	--	--	--	--
rs140667388^1,2		--	238766415(+)	`TGCCAA/GCCAAA`	1	--	us2k¹		0	--	--	--	--
rs79751980^1,2	C,F,	--	238766547(+)	`CCATCG/ACCTAG`	1	--	us2k¹		2		WA NA	238
rs77453171^1,2		--	238766564(+)	`ATGTAC/TGGTGG`	1	--	us2k¹		1		NA	120
rs145874355^1,2		--	238766660(+)	`TGCTCA/GGGCCT`	1	--	us2k¹		0	--	--	--	--
rs189185109^1,2		--	238766752(+)	`CTTGCA/GCTGCA`	1	--	us2k¹		0	--	--	--	--
rs3754704^1,2	C,F,H,	--	238766765(-)	`CACTCG/ACCTCA`	1	--	us2k¹		14		EA NS NA WA	1818

HapMap Linkage Disequilibrium report for RAMP1 (238767536 - 238820756 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAMP1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAMP1

DNA2.0 Custom Variant and Variant Library Synthesis for RAMP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

RAMP1 for disorders           About GeneDecksing

OMIM gene information: 605153    OMIM disorders: --

13 diseases for RAMP1:    About MalaCards

thyroiditis myocardial infarction migraine cerebral infarction

pertussis cerebritis pancreatic cancer prostate cancer

asthma pancreatitis hypertension hypoxia

prostatitis

1 disease from the University of Copenhagen DISEASES database for RAMP1:

Migraine

3 Novoseek disease relationships for RAMP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
migraine	43.9	3	17344407 (1), 18240900 (1)
cardiovascular diseases	0	1	18198792 (1)
heart failure	0	4	15300632 (2)

Human Genome Epidemiology (HuGE) Navigator: RAMP1 (1 document)

Export disorders for RAMP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for RAMP1 gene, integrated from 9 sources (see all 144):
(articles sorted by number of sources associating them with RAMP1)

Utopia: connect your pdf to the dynamic
world of online information

Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PubMed id 18593822)^{1, 7, 9} Qi T....Hay D.L. (2008)
Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. (PubMed id 18725456)^{1, 2, 9} Kusano S....Yokoyama S. (2008)
RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PubMed id 9620797)^{1, 2, 9} McLatchie L.M.... Foord S.M. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. (PubMed id 17310067)^{1, 9} Cottrell G.S....Bunnett N.W. (2007)
Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. (PubMed id 11847213)^{1, 9} Mallee J.J....Kane S.A. (2002)
Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. (PubMed id 11535606)^{1, 9} Hilairet S....Bouvier M. (2001)
Receptor activity-modifying protein 1 increases baror eflex sensitivity and attenuates Angiotensin-induced hypertension. (PubMed id 20100989)^{1, 9} Sabharwal R....Chapleau M.W. (2010)
Mapping the CGRP receptor ligand binding domain: tryp tophan-84 of RAMP1 is critical for agonist and antagonist binding. (PubMed id 20188075)^{1, 9} Moore E.L....Salvatore C.A. (2010)
Interaction of receptor-activity-modifying protein1 with tubulin. (PubMed id 17493758)^{1, 9} Kunz T.H....Born W. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10267	HGNC: 9843	AceView: RAMP1	Ensembl:ENSG00000132329	euGenes: HUgn10267
ECgene: RAMP1	Kegg: 10267	H-InvDB: RAMP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAMP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAMP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for RAMP1 gene:
Search GeneIP for patents involving RAMP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for RAMP1 (RAMP1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for RAMP1		OriGene shRNA RFP for RAMP1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAMP1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAMP1
	OriGene Protein Over-expression Lysate for RAMP1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for RAMP1		OriGene 3'-UTR Clone for RAMP1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAMP1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RAMP1		OriGene Custom Protein Services for RAMP1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAMP1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAMP1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAMP1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAMP1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAMP1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAMP1

	GenScript Custom Purified and Recombinant Proteins Services for RAMP1		GenScript cDNA clones with any tag delivered in your preferred vector for RAMP1
	GenScript Custom Assay Services for RAMP1		GenScript Custom Superior Antibodies Services for RAMP1
	GenScript Custom overexpressing Cell Line Services for RAMP1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in RAMP1 promoter
	Search Chromatin IP Primers for RAMP1
	RT² qPCR Primer Assay in human, mouse, rat RAMP1
	GNC Network for RAMP1
	SABiosciences Custom PCR Arrays for RAMP1

Tocris compounds for RAMP1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RAMP1 antibodies
	RAMP1 proteins
	RAMP1 lysates

	Antibodies for RAMP1
	See all of Abcam's Antibodies, Kits and Proteins for RAMP1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

RAMP1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for RAMP1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAMP1

	SwitchGear 3'UTR luciferase reporter plasmids for RAMP1
	SwitchGear Promoter luciferase reporter plasmids for RAMP1

ThermoFisher Antibodies for RAMP1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAMP1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RAMP1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

RAMP1 Gene

receptor (G protein-coupled) activity modifying protein...

Aliases
for RAMP1 gene

Summaries
for RAMP1 gene

Genomic Views
for RAMP1 gene

Proteins
for RAMP1 gene

Protein Domains /
Families
for RAMP1 gene

Function
for RAMP1 gene

Pathways & Interactions
for RAMP1 gene

Drugs & Compounds
for RAMP1 gene

Transcripts
for RAMP1 gene

Expression
for RAMP1 gene

Orthologs
for RAMP1 gene

Paralogs
for RAMP1 gene

Genomic Variants
for RAMP1 gene

Disorders / Diseases
for RAMP1 gene

Publications
for RAMP1 gene

External Searches for RAMP1 gene

Genome Databases showing RAMP1 gene

Other Databases showing RAMP1 gene

Specialized Databases showing RAMP1 gene

Intellectual Property
for RAMP1 gene

Products
for RAMP1 gene

View Random Gene

Advanced Search

Export list of displayed genes

RAMP1 Gene

receptor (G protein-coupled) activity modifying protein...

Aliasesfor RAMP1 gene

Summariesfor RAMP1 gene

Genomic Viewsfor RAMP1 gene

Proteinsfor RAMP1 gene

Protein Domains /Familiesfor RAMP1 gene

Functionfor RAMP1 gene

Pathways & Interactionsfor RAMP1 gene

Drugs & Compoundsfor RAMP1 gene

Transcriptsfor RAMP1 gene

Expression for RAMP1 gene

Orthologsfor RAMP1 gene

Paralogsfor RAMP1 gene

Genomic Variantsfor RAMP1 gene

Disorders / Diseasesfor RAMP1 gene

Publicationsfor RAMP1 gene

External Searches for RAMP1 gene

Genome Databases showing RAMP1 gene

Other Databases showing RAMP1 gene

Specialized Databases showing RAMP1 gene

Intellectual Propertyfor RAMP1 gene

Productsfor RAMP1 gene

View Random Gene

Aliases
for RAMP1 gene

Summaries
for RAMP1 gene

Genomic Views
for RAMP1 gene

Proteins
for RAMP1 gene

Protein Domains /
Families
for RAMP1 gene

Function
for RAMP1 gene

Pathways & Interactions
for RAMP1 gene

Drugs & Compounds
for RAMP1 gene

Transcripts
for RAMP1 gene

Expression
for RAMP1 gene

Orthologs
for RAMP1 gene

Paralogs
for RAMP1 gene

Genomic Variants
for RAMP1 gene

Disorders / Diseases
for RAMP1 gene

Publications
for RAMP1 gene

Intellectual Property
for RAMP1 gene

Products
for RAMP1 gene