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Aliases for RAMP1 Gene

Aliases for RAMP1 Gene

  • Receptor Activity Modifying Protein 1 2 3
  • Receptor (G Protein-Coupled) Activity Modifying Protein 1 2 5
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1 4
  • Receptor (Calcitonin) Activity Modifying Protein 1 2
  • CRLR Activity-Modifying Protein 1 4

External Ids for RAMP1 Gene

Previous GeneCards Identifiers for RAMP1 Gene

  • GC02P236817
  • GC02P237449
  • GC02P238783
  • GC02P239055
  • GC02P238550
  • GC02P238432
  • GC02P230560
  • GC02P238767

Summaries for RAMP1 Gene

Entrez Gene Summary for RAMP1 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GeneCards Summary for RAMP1 Gene

RAMP1 (Receptor Activity Modifying Protein 1) is a Protein Coding gene. Diseases associated with RAMP1 include migraine with or without aura 1. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP2.

UniProtKB/Swiss-Prot for RAMP1 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Tocris Summary for RAMP1 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys.

Gene Wiki entry for RAMP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP1 Gene

Genomics for RAMP1 Gene

Regulatory Elements for RAMP1 Gene

Promoters for RAMP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAMP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAMP1 Gene

Chromosome:
2
Start:
237,858,893 bp from pter
End:
237,912,114 bp from pter
Size:
53,222 bases
Orientation:
Plus strand

Genomic View for RAMP1 Gene

Genes around RAMP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAMP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP1 Gene

Proteins for RAMP1 Gene

  • Protein details for RAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60894-RAMP1_HUMAN
    Recommended name:
    Receptor activity-modifying protein 1
    Protein Accession:
    O60894
    Secondary Accessions:
    • Q6FGS5

    Protein attributes for RAMP1 Gene

    Size:
    148 amino acids
    Molecular mass:
    16988 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP1.

    Three dimensional structures from OCA and Proteopedia for RAMP1 Gene

neXtProt entry for RAMP1 Gene

Proteomics data for RAMP1 Gene at MOPED

Post-translational modifications for RAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAMP1 Gene

Antibody Products

No data available for DME Specific Peptides for RAMP1 Gene

Domains & Families for RAMP1 Gene

Protein Domains for RAMP1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RAMP1 Gene

Graphical View of Domain Structure for InterPro Entry

O60894

UniProtKB/Swiss-Prot:

RAMP1_HUMAN :
  • Belongs to the RAMP family.
Family:
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP1: view

Function for RAMP1 Gene

Molecular function for RAMP1 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
genes like me logo Genes that share ontologies with RAMP1: view
genes like me logo Genes that share phenotypes with RAMP1: view

Animal Models for RAMP1 Gene

MGI Knock Outs for RAMP1:

Animal Model Products

miRNA for RAMP1 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAMP1 Gene

Localization for RAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAMP1 Gene COMPARTMENTS Subcellular localization image for RAMP1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
mitochondrion 2
nucleus 2
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for RAMP1 Gene

Pathways & Interactions for RAMP1 Gene

genes like me logo Genes that share pathways with RAMP1: view

Pathways by source for RAMP1 Gene

Gene Ontology (GO) - Biological Process for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006816 calcium ion transport IDA 10882736
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0015031 protein transport IDA 10882736
GO:0072659 protein localization to plasma membrane IDA 10882736
genes like me logo Genes that share ontologies with RAMP1: view

No data available for SIGNOR curated interactions for RAMP1 Gene

Drugs & Compounds for RAMP1 Gene

(7) Drugs for RAMP1 Gene - From: Novoseek, DGIdb, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pramlintide Approved, Investigational Pharma agonist, Target 42
Salmon Calcitonin Approved, Investigational Pharma binder 50

(6) Additional Compounds for RAMP1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-CGRP (human)
90954-53-3
Calcitonin (salmon)
47931-85-1
CGRP (rat)
83651-90-5
PHM 27 (human)
118025-43-7
SUN-B 8155
345893-91-6
genes like me logo Genes that share compounds with RAMP1: view

Transcripts for RAMP1 Gene

Unigene Clusters for RAMP1 Gene

Receptor (G protein-coupled) activity modifying protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: -

Relevant External Links for RAMP1 Gene

GeneLoc Exon Structure for
RAMP1
ECgene alternative splicing isoforms for
RAMP1

Expression for RAMP1 Gene

mRNA expression in normal human tissues for RAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP1 Gene

This gene is overexpressed in Uterus (x5.0).

Protein differential expression in normal tissues from HIPED for RAMP1 Gene

This gene is overexpressed in Liver (60.1) and Spinal cord (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAMP1 Gene



SOURCE GeneReport for Unigene cluster for RAMP1 Gene Hs.471783

mRNA Expression by UniProt/SwissProt for RAMP1 Gene

O60894-RAMP1_HUMAN
Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
genes like me logo Genes that share expression patterns with RAMP1: view

Protein tissue co-expression partners for RAMP1 Gene

Primer Products

In Situ Assay Products

Orthologs for RAMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAMP1 36
  • 98 (a)
OneToOne
RAMP1 35
  • 99.1 (n)
  • 97.97 (a)
cow
(Bos Taurus)
Mammalia RAMP1 36
  • 38 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAMP1 36
  • 60 (a)
OneToOne
RAMP1 35
  • 79.08 (n)
  • 69.34 (a)
mouse
(Mus musculus)
Mammalia Ramp1 16
Ramp1 35
  • 79.28 (n)
  • 70.95 (a)
Ramp1 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAMP1 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ramp1 35
  • 79.5 (n)
  • 71.62 (a)
chicken
(Gallus gallus)
Aves RAMP1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAMP1 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp1 35
  • 58.11 (n)
  • 49.32 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:91818 35
  • 57.55 (n)
  • 51.08 (a)
RAMP1 36
  • 48 (a)
OneToOne
Species with no ortholog for RAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP1 Gene

ENSEMBL:
Gene Tree for RAMP1 (if available)
TreeFam:
Gene Tree for RAMP1 (if available)

Paralogs for RAMP1 Gene

Paralogs for RAMP1 Gene

(2) SIMAP similar genes for RAMP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAMP1: view

Variants for RAMP1 Gene

Sequence variations from dbSNP and Humsavar for RAMP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs186220 -- 237,888,011(+) TTCAT(A/G)CAAGT intron-variant
rs590395 -- 237,888,817(-) TCCAG(C/T)CTGGG intron-variant
rs687877 -- 237,888,818(+) CCAGG(C/T)TGGAG intron-variant
rs302673 -- 237,886,960(+) GCCAC(A/G)CCCCC intron-variant
rs302674 -- 237,887,898(+) TGACA(A/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv519581 CNV Loss 19592680
nsv516443 CNV Gain+Loss 19592680
nsv876061 CNV Loss 21882294
esv274938 CNV Loss 21479260
esv2657266 CNV Deletion 23128226
nsv508205 CNV Loss 20534489
nsv527428 CNV Loss 19592680
esv2661727 CNV Deletion 23128226

Variation tolerance for RAMP1 Gene

Residual Variation Intolerance Score: 60.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAMP1 Gene

HapMap Linkage Disequilibrium report
RAMP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP1 Gene

Disorders for RAMP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAMP1 Gene - From: DISEASES and Novoseek

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards
Search RAMP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAMP1

Genetic Association Database (GAD)
RAMP1
Human Genome Epidemiology (HuGE) Navigator
RAMP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAMP1
genes like me logo Genes that share disorders with RAMP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAMP1 Gene

Publications for RAMP1 Gene

  1. Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. (PMID: 18725456) Kusano S. … Yokoyama S. (Protein Sci. 2008) 3 4 23 67
  2. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  3. Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension. (PMID: 20100989) Sabharwal R. … Chapleau M.W. (Hypertension 2010) 3 23
  4. Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction. (PMID: 19710695) Nakazato T. … Doba N. (J Hum Hypertens 2010) 3 23
  5. Mapping the CGRP receptor ligand binding domain: tryptophan-84 of RAMP1 is critical for agonist and antagonist binding. (PMID: 20188075) Moore E.L. … Salvatore C.A. (Biochem. Biophys. Res. Commun. 2010) 3 23

Products for RAMP1 Gene

Sources for RAMP1 Gene

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