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Aliases for RAMP1 Gene

Aliases for RAMP1 Gene

  • Receptor (G Protein-Coupled) Activity Modifying Protein 1 2 3
  • Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 1 4
  • Receptor (Calcitonin) Activity Modifying Protein 1 2
  • Receptor Activity Modifying Protein 1 2
  • CRLR Activity-Modifying Protein 1 4

External Ids for RAMP1 Gene

Previous GeneCards Identifiers for RAMP1 Gene

  • GC02P236817
  • GC02P237449
  • GC02P238783
  • GC02P239055
  • GC02P238550
  • GC02P238432
  • GC02P230560
  • GC02P238767

Summaries for RAMP1 Gene

Entrez Gene Summary for RAMP1 Gene

  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAMP1 Gene

RAMP1 (Receptor (G Protein-Coupled) Activity Modifying Protein 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include receptor activity and coreceptor activity. An important paralog of this gene is RAMP3.

UniProtKB/Swiss-Prot for RAMP1 Gene

  • Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Tocris Summary for RAMP1 Gene

  • Calcitonin and related receptors are a family of G-protein-coupled receptors that comprises of eight subtypes; CT, AMY1, AMY2, AMY3, CALCR, CGRP, AM1 and AM2. The receptors have a wide biological distribution; high concentrations are found in the brain, lung, liver, heart and spleen with lower expression levels present in the testes, gastrointestinal tract and thyroid. The main function of CT receptors is to inhibit bone reabsorption and enhance calcium excretion by the kidneys. AMY receptors are heterodimers of the CT receptor and receptor activating modifying proteins (RAMP) 1-3, which have been implicated in type II diabetes pathology. The CALCRL receptor alone is non-functioning, but forms heterodimers with RAMPs to form the CGRP (CALCRL with RAMP1), AM1 (CALCRL with RAMP2) and AM2 (CALCRL with RAMP3) receptors. Their main function is inducing vasodilation, which causes hypotension.

Gene Wiki entry for RAMP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAMP1 Gene

Genomics for RAMP1 Gene

Regulatory Elements for RAMP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAMP1 Gene

237,858,893 bp from pter
237,912,114 bp from pter
53,222 bases
Plus strand

Genomic View for RAMP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAMP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAMP1 Gene

Proteins for RAMP1 Gene

  • Protein details for RAMP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Receptor activity-modifying protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6FGS5

    Protein attributes for RAMP1 Gene

    148 amino acids
    Molecular mass:
    16988 Da
    Quaternary structure:
    • Heterodimer of CALCRL and RAMP1.

    Three dimensional structures from OCA and Proteopedia for RAMP1 Gene

neXtProt entry for RAMP1 Gene

Proteomics data for RAMP1 Gene at MOPED

Post-translational modifications for RAMP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAMP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAMP1 Gene

Domains for RAMP1 Gene

Gene Families for RAMP1 Gene

  • RAMP :Receptor (G protein-coupled) activity modifying proteins

Protein Domains for RAMP1 Gene


Suggested Antigen Peptide Sequences for RAMP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • O60894
  • Belongs to the RAMP family.
genes like me logo Genes that share domains with RAMP1: view

Function for RAMP1 Gene

Molecular function for RAMP1 Gene

UniProtKB/Swiss-Prot Function:
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

Gene Ontology (GO) - Molecular Function for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity IDA 10882736
GO:0004948 calcitonin receptor activity IDA 9620797
GO:0005515 protein binding IPI 14722252
GO:0008565 protein transporter activity IDA 10882736
GO:0015026 coreceptor activity IEA --
genes like me logo Genes that share ontologies with RAMP1: view
genes like me logo Genes that share phenotypes with RAMP1: view

Animal Models for RAMP1 Gene

MGI Knock Outs for RAMP1:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RAMP1 Gene

Localization for RAMP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAMP1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for RAMP1 Gene COMPARTMENTS Subcellular localization image for RAMP1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9620797
GO:0009986 cell surface IDA 14722252
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with RAMP1: view

Pathways for RAMP1 Gene

genes like me logo Genes that share pathways with RAMP1: view

Pathways by source for RAMP1 Gene

Gene Ontology (GO) - Biological Process for RAMP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IDA 20596610
GO:0006816 calcium ion transport IDA 10882736
GO:0006886 intracellular protein transport IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway IDA 9620797
genes like me logo Genes that share ontologies with RAMP1: view

Compounds for RAMP1 Gene

(5) Tocris Compounds for RAMP1 Gene

Compound Action Cas Number
AC 187 Potent and selective amylin receptor antagonist [151804-77-2]
alpha-CGRP (human) CGRP receptor agonist [90954-53-3]
BIBN 4096 Potent and selective CGRP receptor antagonist [204697-65-4]
CGRP (rat) Potent vasodilator [83651-90-5]
CGRP 8-37 (rat) CGRP1 receptor antagonist [129121-73-9]

(1) Drugbank Compounds for RAMP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
151126-32-8 target agonist

(6) Novoseek inferred chemical compound relationships for RAMP1 Gene

Compound -log(P) Hits PubMed IDs
bibn 4096 bs 93.7 10
alanine 31.5 5
potassium 1.27 1
dexamethasone 0 5
nitric oxide 0 1
genes like me logo Genes that share compounds with RAMP1: view

Transcripts for RAMP1 Gene

Unigene Clusters for RAMP1 Gene

Receptor (G protein-coupled) activity modifying protein 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAMP1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAMP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: - -
SP3: -

Relevant External Links for RAMP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAMP1 Gene

mRNA expression in normal human tissues for RAMP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAMP1 Gene

This gene is overexpressed in Uterus (5.0).

Protein differential expression in normal tissues for RAMP1 Gene

This gene is overexpressed in Liver (60.1) and Spinal cord (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAMP1 Gene

SOURCE GeneReport for Unigene cluster for RAMP1 Gene Hs.471783

mRNA Expression by UniProt/SwissProt for RAMP1 Gene

Tissue specificity: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
genes like me logo Genes that share expressions with RAMP1: view

Expression partners for RAMP1 Gene

In Situ Assay Products

Orthologs for RAMP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAMP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia RAMP1 35
  • 79.08 (n)
  • 69.34 (a)
RAMP1 36
  • 60 (a)
(Mus musculus)
Mammalia Ramp1 35
  • 79.28 (n)
  • 70.95 (a)
Ramp1 16
Ramp1 36
  • 71 (a)
(Pan troglodytes)
Mammalia RAMP1 35
  • 99.1 (n)
  • 97.97 (a)
RAMP1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ramp1 35
  • 79.5 (n)
  • 71.62 (a)
(Bos Taurus)
Mammalia RAMP1 36
  • 38 (a)
(Ornithorhynchus anatinus)
Mammalia RAMP1 36
  • 52 (a)
(Gallus gallus)
Aves RAMP1 36
  • 56 (a)
(Anolis carolinensis)
Reptilia RAMP1 36
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ramp1 35
  • 58.11 (n)
  • 49.32 (a)
(Danio rerio)
Actinopterygii zgc:91818 35
  • 57.55 (n)
  • 51.08 (a)
RAMP1 36
  • 48 (a)
Species with no ortholog for RAMP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAMP1 Gene

Gene Tree for RAMP1 (if available)
Gene Tree for RAMP1 (if available)

Paralogs for RAMP1 Gene

Paralogs for RAMP1 Gene

Selected SIMAP similar genes for RAMP1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAMP1: view

Variants for RAMP1 Gene

Sequence variations from dbSNP and Humsavar for RAMP1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs91867 -- 237,885,539(+) TCATC(C/T)CTGTG intron-variant
rs186220 -- 237,888,011(+) TTCAT(A/G)CAAGT intron-variant
rs302670 -- 237,886,062(-) CAGAC(C/T)GGTGT intron-variant
rs302671 -- 237,886,321(+) CAGGG(C/G)TCAGA intron-variant
rs302672 -- 237,886,369(+) GGGTT(A/G)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAMP1 Gene

Variant ID Type Subtype PubMed ID
nsv519581 CNV Loss 19592680
nsv516443 CNV Gain+Loss 19592680
nsv876061 CNV Loss 21882294
esv274938 CNV Loss 21479260
esv2657266 CNV Deletion 23128226
nsv508205 CNV Loss 20534489
nsv527428 CNV Loss 19592680
esv2661727 CNV Deletion 23128226

Relevant External Links for RAMP1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAMP1 Gene

Disorders for RAMP1 Gene

(1) University of Copenhagen DISEASES for RAMP1 Gene

(3) Novoseek inferred disease relationships for RAMP1 Gene

Disease -log(P) Hits PubMed IDs
migraine 43.9 2
cardiovascular diseases 0 1
heart failure 0 2

Relevant External Links for RAMP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAMP1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for RAMP1 Gene

Publications for RAMP1 Gene

  1. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. (PMID: 9620797) McLatchie L.M. … Foord S.M. (Nature 1998) 3 4 23
  2. Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. (PMID: 18725456) Kusano S. … Yokoyama S. (Protein Sci. 2008) 3 4 23
  3. Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction. (PMID: 19710695) Nakazato T. … Doba N. (J Hum Hypertens 2010) 3 23 48
  4. Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. (PMID: 18593822) Qi T. … Hay D.L. (Mol. Pharmacol. 2008) 3 23 25
  5. Interaction of receptor-activity-modifying protein1 with tubulin. (PMID: 17493758) Kunz T.H. … Born W. (Biochim. Biophys. Acta 2007) 3 23

Products for RAMP1 Gene

Sources for RAMP1 Gene

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