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Aliases for RALYL Gene

Aliases for RALYL Gene

  • RALY RNA Binding Protein-Like 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein C-Like 3 3 4
  • HnRNP Core Protein C-Like 3 3 4
  • HNRPCL3 3 4
  • RNA-Binding Raly-Like Protein 3
  • HRALYL 4

External Ids for RALYL Gene

Previous GeneCards Identifiers for RALYL Gene

  • GC08P085259
  • GC08P085095
  • GC08P080586

Summaries for RALYL Gene

GeneCards Summary for RALYL Gene

RALYL (RALY RNA Binding Protein-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is RALY.

Gene Wiki entry for RALYL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALYL Gene

Genomics for RALYL Gene

Regulatory Elements for RALYL Gene

Enhancers for RALYL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RALYL on UCSC Golden Path with GeneCards custom track

Promoters for RALYL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for RALYL Gene

Chromosome:
8
Start:
84,182,787 bp from pter
End:
84,921,844 bp from pter
Size:
739,058 bases
Orientation:
Plus strand

Genomic View for RALYL Gene

Genes around RALYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALYL Gene

Proteins for RALYL Gene

  • Protein details for RALYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SE5-RALYL_HUMAN
    Recommended name:
    RNA-binding Raly-like protein
    Protein Accession:
    Q86SE5
    Secondary Accessions:
    • B3KTH2
    • G3V129
    • Q6ZW87
    • Q8N1C2

    Protein attributes for RALYL Gene

    Size:
    291 amino acids
    Molecular mass:
    32331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALYL Gene

Post-translational modifications for RALYL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RALYL Gene

Domains & Families for RALYL Gene

Gene Families for RALYL Gene

Protein Domains for RALYL Gene

Graphical View of Domain Structure for InterPro Entry

Q86SE5

UniProtKB/Swiss-Prot:

RALYL_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with RALYL: view

Function for RALYL Gene

Gene Ontology (GO) - Molecular Function for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RALYL: view
genes like me logo Genes that share phenotypes with RALYL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RALYL Gene

Localization for RALYL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALYL Gene COMPARTMENTS Subcellular localization image for RALYL gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with RALYL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RALYL Gene

Pathways & Interactions for RALYL Gene

SuperPathways for RALYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALYL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RALYL Gene

Drugs & Compounds for RALYL Gene

No Compound Related Data Available

Transcripts for RALYL Gene

Unigene Clusters for RALYL Gene

RALY RNA binding protein-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALYL Gene

No ASD Table

Relevant External Links for RALYL Gene

GeneLoc Exon Structure for
RALYL
ECgene alternative splicing isoforms for
RALYL

Expression for RALYL Gene

mRNA expression in normal human tissues for RALYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALYL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Frontal Cortex (BA9) (x5.4), Brain - Hypothalamus (x4.7), and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for RALYL Gene

This gene is overexpressed in Lung (51.8) and Fetal Brain (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RALYL Gene



Protein tissue co-expression partners for RALYL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RALYL Gene:

RALYL

SOURCE GeneReport for Unigene cluster for RALYL Gene:

Hs.121663

mRNA Expression by UniProt/SwissProt for RALYL Gene:

Q86SE5-RALYL_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain.
genes like me logo Genes that share expression patterns with RALYL: view

Primer Products

Orthologs for RALYL Gene

This gene was present in the common ancestor of animals.

Orthologs for RALYL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RALYL 34
  • 87.17 (n)
  • 93.13 (a)
RALYL 35
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC487025 34
  • 92.42 (n)
  • 95.1 (a)
-- 35
  • 90 (a)
OneToMany
-- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ralyl 34
  • 88.66 (n)
  • 95.53 (a)
Ralyl 16
Ralyl 35
  • 89 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RALYL 34
  • 99.89 (n)
  • 100 (a)
RALYL 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves RALYL 34
  • 84.07 (n)
  • 91.22 (a)
-- 35
  • 92 (a)
OneToMany
RALYL 35
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RALYL 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralyl 34
  • 76.21 (n)
  • 85.51 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100148343 34
  • 62.95 (n)
  • 63.85 (a)
CABZ01071757.1 35
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42458 35
  • 11 (a)
OneToMany
Species where no ortholog for RALYL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALYL Gene

ENSEMBL:
Gene Tree for RALYL (if available)
TreeFam:
Gene Tree for RALYL (if available)

Paralogs for RALYL Gene

Paralogs for RALYL Gene

(7) SIMAP similar genes for RALYL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RALYL: view

Variants for RALYL Gene

Sequence variations from dbSNP and Humsavar for RALYL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs956907 -- 84,762,690(+) AATAA(A/G)ACTTT intron-variant
rs957815 -- 84,757,174(+) CTATG(A/G)ATATT intron-variant
rs957816 -- 84,757,234(+) TCATA(C/T)GCAGC intron-variant
rs959433 -- 84,207,155(-) AGTGG(A/G)ATTGT intron-variant
rs965734 -- 84,915,508(+) ATTTA(A/G)ACTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALYL Gene

Variant ID Type Subtype PubMed ID
dgv1190n67 CNV loss 20364138
dgv12222n54 CNV loss 21841781
dgv12223n54 CNV loss 21841781
dgv12224n54 CNV loss 21841781
dgv12225n54 CNV loss 21841781
dgv12226n54 CNV loss 21841781
dgv149n17 CNV loss 16327808
dgv463n21 CNV gain 19592680
dgv7251n100 CNV loss 25217958
dgv7252n100 CNV loss 25217958
dgv7253n100 CNV loss 25217958
dgv7254n100 CNV gain 25217958
esv1023341 CNV insertion 17803354
esv1917544 CNV deletion 18987734
esv21659 CNV loss 19812545
esv21722 CNV loss 19812545
esv23119 CNV gain 19812545
esv2414076 CNV deletion 18987734
esv2421860 CNV deletion 20811451
esv2521393 CNV insertion 19546169
esv2669927 CNV deletion 23128226
esv2678686 CNV deletion 23128226
esv2737254 CNV deletion 23290073
esv2737255 CNV deletion 23290073
esv2737256 CNV deletion 23290073
esv2752268 CNV gain 17911159
esv2761174 CNV gain 21179565
esv2761218 CNV loss 21179565
esv2764062 CNV loss 21179565
esv28210 CNV gain 19812545
esv3304895 CNV mobile element insertion 20981092
esv3307107 CNV mobile element insertion 20981092
esv3396834 CNV insertion 20981092
esv3407934 CNV duplication 20981092
esv3410613 CNV insertion 20981092
esv3438881 CNV insertion 20981092
esv3543779 CNV deletion 23714750
esv3543780 CNV deletion 23714750
esv3572879 CNV loss 25503493
esv3572880 CNV loss 25503493
esv3572881 CNV loss 25503493
esv3617852 CNV loss 21293372
esv3617854 CNV loss 21293372
esv3617855 CNV loss 21293372
esv3617856 CNV gain 21293372
esv3617858 CNV loss 21293372
esv3617860 CNV loss 21293372
esv3617862 CNV loss 21293372
esv3617863 CNV loss 21293372
esv3617864 CNV loss 21293372
esv3891428 CNV loss 25118596
nsv1017411 CNV loss 25217958
nsv1030263 CNV gain 25217958
nsv1033771 CNV loss 25217958
nsv1068715 OTHER inversion 25765185
nsv1078617 CNV duplication 25765185
nsv1112473 CNV deletion 24896259
nsv1115111 CNV deletion 24896259
nsv1128435 CNV deletion 24896259
nsv1128977 CNV duplication 24896259
nsv1146309 CNV duplication 26484159
nsv1161778 CNV deletion 26073780
nsv1161779 CNV deletion 26073780
nsv436574 CNV deletion 17901297
nsv438067 CNV loss 16468122
nsv442524 CNV loss 18776908
nsv476627 CNV novel sequence insertion 20440878
nsv483126 CNV gain+loss 15286789
nsv499568 CNV loss 21111241
nsv515106 CNV loss 21397061
nsv522543 CNV loss 19592680
nsv611646 CNV loss 21841781
nsv611649 CNV loss 21841781
nsv611650 CNV loss 21841781
nsv6281 CNV deletion 18451855
nsv6282 CNV insertion 18451855
nsv6283 CNV insertion 18451855
nsv819991 CNV gain 19587683
nsv820872 CNV deletion 20802225
nsv824681 CNV loss 20364138
nsv831374 CNV loss 17160897
nsv831375 CNV gain 17160897
nsv831376 CNV gain 17160897
nsv8361 CNV gain 18304495
nsv972232 CNV deletion 23825009

Variation tolerance for RALYL Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALYL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALYL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALYL Gene

Disorders for RALYL Gene

Relevant External Links for RALYL

Genetic Association Database (GAD)
RALYL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALYL

No disorders were found for RALYL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALYL Gene

Publications for RALYL Gene

  1. A novel cDNA encodes a putative hRALY-like protein, hRALYL. (PMID: 12688537) Ji C.N. … Mao Y.M. (Mol. Biol. Rep. 2003) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 65
  5. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3 65

Products for RALYL Gene

Sources for RALYL Gene

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