Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RALYL Gene

Aliases for RALYL Gene

  • RALY RNA Binding Protein-Like 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein C-Like 3 3 4
  • HnRNP Core Protein C-Like 3 3 4
  • HNRPCL3 3 4
  • HRALYL 4

External Ids for RALYL Gene

Previous GeneCards Identifiers for RALYL Gene

  • GC08P085259
  • GC08P085095
  • GC08P080586

Summaries for RALYL Gene

GeneCards Summary for RALYL Gene

RALYL (RALY RNA Binding Protein-Like) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is HNRNPCL3.

Gene Wiki entry for RALYL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALYL Gene

Genomics for RALYL Gene

Regulatory Elements for RALYL Gene

Enhancers for RALYL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RALYL on UCSC Golden Path with GeneCards custom track

Genomic Location for RALYL Gene

84,182,787 bp from pter
84,921,844 bp from pter
739,058 bases
Plus strand

Genomic View for RALYL Gene

Genes around RALYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALYL Gene

Proteins for RALYL Gene

  • Protein details for RALYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding Raly-like protein
    Protein Accession:
    Secondary Accessions:
    • B3KTH2
    • G3V129
    • Q6ZW87
    • Q8N1C2

    Protein attributes for RALYL Gene

    291 amino acids
    Molecular mass:
    32331 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALYL Gene


neXtProt entry for RALYL Gene

Proteomics data for RALYL Gene at MOPED

Post-translational modifications for RALYL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RALYL Gene

Domains & Families for RALYL Gene

Gene Families for RALYL Gene

Protein Domains for RALYL Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with RALYL: view

Function for RALYL Gene

Gene Ontology (GO) - Molecular Function for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0042802 identical protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RALYL: view

Phenotypes for RALYL Gene

genes like me logo Genes that share phenotypes with RALYL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RALYL Gene

Localization for RALYL Gene

Subcellular locations from

Jensen Localization Image for RALYL Gene COMPARTMENTS Subcellular localization image for RALYL gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RALYL Gene

Pathways & Interactions for RALYL Gene

SuperPathways for RALYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALYL Gene


No data available for Pathways by source and SIGNOR curated interactions for RALYL Gene

Drugs & Compounds for RALYL Gene

No Compound Related Data Available

Transcripts for RALYL Gene

Unigene Clusters for RALYL Gene

RALY RNA binding protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALYL Gene

No ASD Table

Relevant External Links for RALYL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RALYL Gene

mRNA expression in normal human tissues for RALYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALYL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Frontal Cortex (BA9) (x5.4), Brain - Hypothalamus (x4.7), and Brain - Cerebellum (x4.3).

Protein differential expression in normal tissues from HIPED for RALYL Gene

This gene is overexpressed in Lung (51.8) and Fetal Brain (14.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RALYL Gene

SOURCE GeneReport for Unigene cluster for RALYL Gene Hs.121663

mRNA Expression by UniProt/SwissProt for RALYL Gene

Tissue specificity: Widely expressed, with highest levels in brain.
genes like me logo Genes that share expression patterns with RALYL: view

Protein tissue co-expression partners for RALYL Gene

- Elite partner

Primer Products

Orthologs for RALYL Gene

This gene was present in the common ancestor of animals.

Orthologs for RALYL Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RALYL 35
  • 87.17 (n)
  • 93.13 (a)
  • 91 (a)
(Canis familiaris)
Mammalia LOC487025 35
  • 92.42 (n)
  • 95.1 (a)
-- 36
  • 90 (a)
-- 36
  • 93 (a)
(Mus musculus)
Mammalia Ralyl 35
  • 88.66 (n)
  • 95.53 (a)
Ralyl 16
Ralyl 36
  • 89 (a)
(Pan troglodytes)
Mammalia RALYL 35
  • 99.89 (n)
  • 100 (a)
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
-- 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 85 (a)
-- 36
  • 61 (a)
(Gallus gallus)
Aves RALYL 35
  • 84.07 (n)
  • 91.22 (a)
-- 36
  • 92 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia RALYL 36
  • 91 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ralyl 35
  • 76.21 (n)
  • 85.51 (a)
(Danio rerio)
Actinopterygii LOC100148343 35
  • 62.95 (n)
  • 63.85 (a)
CABZ01071757.1 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42458 36
  • 11 (a)
Species with no ortholog for RALYL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALYL Gene

Gene Tree for RALYL (if available)
Gene Tree for RALYL (if available)

Paralogs for RALYL Gene

Paralogs for RALYL Gene

(7) SIMAP similar genes for RALYL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RALYL: view

Variants for RALYL Gene

Sequence variations from dbSNP and Humsavar for RALYL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2029358 -- 84,659,062(+) AGGCT(A/G)TATAG intron-variant
rs2029581 -- 84,337,813(+) CAACT(C/T)ACCTT intron-variant
rs2042763 -- 84,853,838(+) GTTTT(C/T)TTTTT intron-variant
rs2042764 -- 84,860,230(+) TCATT(A/G)TATAT intron-variant
rs2046313 -- 84,540,938(-) tgcta(A/G)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALYL Gene

Variant ID Type Subtype PubMed ID
esv2752268 CNV Gain 17911159
nsv831374 CNV Loss 17160897
esv1917544 CNV Deletion 18987734
esv2737254 CNV Deletion 23290073
nsv522543 CNV Loss 19592680
esv2737255 CNV Deletion 23290073
esv2414076 CNV Deletion 18987734
esv2737256 CNV Deletion 23290073
esv271383 CNV Insertion 20981092
esv23119 CNV Gain 19812545
nsv6281 CNV Loss 18451855
dgv149n17 CNV Loss 16327808
nsv8361 CNV Gain 18304495
dgv1190n67 CNV Loss 20364138
nsv820872 CNV Deletion 20802225
nsv436574 CNV Deletion 17901297
nsv819991 CNV Gain 19587683
esv2678686 CNV Deletion 23128226
nsv499568 CNV Loss 21111241
nsv515106 CNV Loss 21397061
esv28210 CNV Gain 19812545
nsv438067 CNV Loss 16468122
esv2421860 CNV Deletion 20811451
nsv442524 CNV CNV 18776908
nsv831375 CNV Gain 17160897
dgv463n21 CNV Gain 19592680
nsv6282 CNV Insertion 18451855
esv269173 CNV Insertion 20981092
esv271825 CNV Insertion 20981092
esv272432 CNV Insertion 20981092
esv1023341 CNV Insertion 17803354
esv21722 CNV Loss 19812545
nsv824681 CNV Loss 20364138
nsv831376 CNV Gain 17160897
nsv6283 CNV Insertion 18451855
nsv891115 CNV Loss 21882294
nsv891116 CNV Loss 21882294
esv21659 CNV Loss 19812545
esv2669927 CNV Deletion 23128226
nsv891117 CNV Loss 21882294
dgv7823n71 CNV Loss 21882294
nsv891120 CNV Gain 21882294
nsv891121 CNV Loss 21882294
esv2521393 CNV Insertion 19546169

Variation tolerance for RALYL Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RALYL Gene

Disorders for RALYL Gene

Relevant External Links for RALYL

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RALYL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALYL Gene

Publications for RALYL Gene

  1. A novel cDNA encodes a putative hRALY-like protein, hRALYL. (PMID: 12688537) Ji C.N. … Mao Y.M. (Mol. Biol. Rep. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. (PMID: 24709693) Cobb J. … Thomson W. (Pharmacogenomics J. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for RALYL Gene

Sources for RALYL Gene