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Aliases for RALYL Gene

Aliases for RALYL Gene

  • RALY RNA Binding Protein-Like 2 3
  • Heterogeneous Nuclear Ribonucleoprotein C-Like 3 3 4
  • HnRNP Core Protein C-Like 3 3 4
  • HNRPCL3 3 4
  • RNA-Binding Raly-Like Protein 3
  • HRALYL 4

External Ids for RALYL Gene

Summaries for RALYL Gene

GeneCards Summary for RALYL Gene

RALYL (RALY RNA Binding Protein-Like) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RALY.

Gene Wiki entry for RALYL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALYL Gene

Genomics for RALYL Gene

Genomic Location for RALYL Gene

Start:
84,182,787 bp from pter
End:
84,921,844 bp from pter
Size:
739,058 bases
Orientation:
Plus strand

Genomic View for RALYL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALYL Gene

Regulatory Elements for RALYL Gene

Proteins for RALYL Gene

  • Protein details for RALYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SE5-RALYL_HUMAN
    Recommended name:
    RNA-binding Raly-like protein
    Protein Accession:
    Q86SE5
    Secondary Accessions:
    • B3KTH2
    • G3V129
    • Q6ZW87
    • Q8N1C2

    Protein attributes for RALYL Gene

    Size:
    291 amino acids
    Molecular mass:
    32331 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31090.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALYL Gene

Proteomics data for RALYL Gene at MOPED

Post-translational modifications for RALYL Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys47

No data available for DME Specific Peptides for RALYL Gene

Domains for RALYL Gene

Gene Families for RALYL Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RALYL Gene

UniProtKB/Swiss-Prot:

RALYL_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q86SE5
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.:
    • Q86SE5
genes like me logo Genes that share domains with RALYL: view

Function for RALYL Gene

Gene Ontology (GO) - Molecular Function for RALYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16189514
GO:0042802 identical protein binding IPI 16189514
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RALYL: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RALYL Gene

Localization for RALYL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALYL Gene COMPARTMENTS Subcellular localization image for RALYL gene
Compartment Confidence
nucleus 3
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RALYL Gene

Pathways for RALYL Gene

SuperPathways for RALYL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALYL Gene

None

No data available for Pathways by source for RALYL Gene

Transcripts for RALYL Gene

Unigene Clusters for RALYL Gene

RALY RNA binding protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALYL Gene

No ASD Table

Relevant External Links for RALYL Gene

GeneLoc Exon Structure for
RALYL
ECgene alternative splicing isoforms for
RALYL

Expression for RALYL Gene

mRNA expression in normal human tissues for RALYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALYL Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (6.0), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Frontal Cortex (BA9) (5.4), Brain - Hypothalamus (4.7), and Brain - Cerebellum (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RALYL Gene

SOURCE GeneReport for Unigene cluster for RALYL Gene Hs.121663

mRNA Expression by UniProt/SwissProt for RALYL Gene

Q86SE5-RALYL_HUMAN
Tissue specificity: Widely expressed, with highest levels in brain.
genes like me logo Genes that share expressions with RALYL: view

Orthologs for RALYL Gene

This gene was present in the common ancestor of animals.

Orthologs for RALYL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALYL 36
  • 99.89 (n)
  • 100 (a)
RALYL 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALYL 36
  • 87.17 (n)
  • 93.13 (a)
RALYL 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 90 (a)
OneToMany
-- 37
  • 93 (a)
OneToMany
LOC487025 36
  • 92.42 (n)
  • 95.1 (a)
mouse
(Mus musculus)
Mammalia Ralyl 36
  • 88.66 (n)
  • 95.53 (a)
Ralyl 16
Ralyl 37
  • 89 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 75 (a)
OneToMany
-- 37
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 61 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 92 (a)
OneToMany
RALYL 36
  • 84.07 (n)
  • 91.22 (a)
RALYL 37
  • 76 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia RALYL 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralyl 36
  • 76.21 (n)
  • 85.51 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01071757.1 37
  • 46 (a)
OneToOne
LOC100148343 36
  • 62.95 (n)
  • 63.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42458 37
  • 11 (a)
OneToMany
Species with no ortholog for RALYL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALYL Gene

ENSEMBL:
Gene Tree for RALYL (if available)
TreeFam:
Gene Tree for RALYL (if available)

Paralogs for RALYL Gene

Paralogs for RALYL Gene

Selected SIMAP similar genes for RALYL Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RALYL: view

Variants for RALYL Gene

Sequence variations from dbSNP and Humsavar for RALYL Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs12604 -- 84,921,582(+) TCTGG(A/G)TATGA utr-variant-3-prime
rs60226 -- 84,432,408(-) acagg(C/T)attga intron-variant
rs60227 -- 84,432,241(-) tccag(A/G)ttcat intron-variant
rs317934 -- 84,424,391(+) GGTTT(G/T)CAGCT intron-variant
rs317936 -- 84,424,942(-) gagag(C/G)agtgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALYL Gene

Variant ID Type Subtype PubMed ID
esv2752268 CNV Gain 17911159
nsv831374 CNV Loss 17160897
esv1917544 CNV Deletion 18987734
esv2737254 CNV Deletion 23290073
nsv522543 CNV Loss 19592680
esv2737255 CNV Deletion 23290073
esv2414076 CNV Deletion 18987734
esv2737256 CNV Deletion 23290073
esv271383 CNV Insertion 20981092
esv23119 CNV Gain 19812545
nsv6281 CNV Loss 18451855
dgv149n17 CNV Loss 16327808
nsv8361 CNV Gain 18304495
dgv1190n67 CNV Loss 20364138
nsv820872 CNV Deletion 20802225
nsv436574 CNV Deletion 17901297
nsv819991 CNV Gain 19587683
esv2678686 CNV Deletion 23128226
nsv499568 CNV Loss 21111241
nsv515106 CNV Loss 21397061
esv28210 CNV Gain 19812545
nsv438067 CNV Loss 16468122
esv2421860 CNV Deletion 20811451
nsv442524 CNV CNV 18776908
nsv831375 CNV Gain 17160897
dgv463n21 CNV Gain 19592680
nsv6282 CNV Insertion 18451855
esv269173 CNV Insertion 20981092
esv271825 CNV Insertion 20981092
esv272432 CNV Insertion 20981092
esv1023341 CNV Insertion 17803354
esv21722 CNV Loss 19812545
nsv824681 CNV Loss 20364138
nsv831376 CNV Gain 17160897
nsv6283 CNV Insertion 18451855
nsv891115 CNV Loss 21882294
nsv891116 CNV Loss 21882294
esv21659 CNV Loss 19812545
esv2669927 CNV Deletion 23128226
nsv891117 CNV Loss 21882294
dgv7823n71 CNV Loss 21882294
nsv891120 CNV Gain 21882294
nsv891121 CNV Loss 21882294
esv2521393 CNV Insertion 19546169

Relevant External Links for RALYL Gene

HapMap Linkage Disequilibrium report
RALYL

Disorders for RALYL Gene

Relevant External Links for RALYL

Genetic Association Database (GAD)
RALYL
genes like me logo Genes that share disorders with RALYL: view

No data available for UniProtKB/Swiss-Prot for RALYL Gene

Publications for RALYL Gene

  1. A novel cDNA encodes a putative hRALY-like protein, hRALYL. (PMID: 12688537) Ji C.N. … Mao Y.M. (Mol. Biol. Rep. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for RALYL Gene

Sources for RALYL Gene

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