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Aliases for RALY Gene

Aliases for RALY Gene

  • RALY Heterogeneous Nuclear Ribonucleoprotein 2 3
  • RNA-Binding Protein (Autoantigenic, HnRNP-Associated With Lethal Yellow) 2 3
  • HnRNP Associated With Lethal Yellow Protein Homolog 3 4
  • Heterogeneous Nuclear Ribonucleoprotein C-Like 2 3 4
  • HnRNP Core Protein C-Like 2 3 4
  • Autoantigen P542 3 4
  • HNRPCL2 3 4
  • P542 3 4
  • RNA Binding Protein, Autoantigenic (HnRNP-Associated With Lethal Yellow Homolog (Mouse)) 2
  • RNA Binding Protein, Autoantigenic (HnRNP-Associated With Lethal Yellow Homolog) 3
  • RNA-Binding Protein (Autoantigenic) 3
  • RNA-Binding Protein Raly 3

External Ids for RALY Gene

Summaries for RALY Gene

Entrez Gene Summary for RALY Gene

  • This gene encodes a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) gene family. This protein may play a role in pre-mRNA splicing and in embryonic development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for RALY Gene

RALY (RALY Heterogeneous Nuclear Ribonucleoprotein) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RALYL.

UniProtKB/Swiss-Prot for RALY Gene

  • Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity).

Gene Wiki entry for RALY Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALY Gene

Genomics for RALY Gene

Genomic Location for RALY Gene

Start:
33,993,646 bp from pter
End:
34,108,308 bp from pter
Size:
114,663 bases
Orientation:
Plus strand

Genomic View for RALY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALY Gene

Regulatory Elements for RALY Gene

Proteins for RALY Gene

  • Protein details for RALY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKM9-RALY_HUMAN
    Recommended name:
    RNA-binding protein Raly
    Protein Accession:
    Q9UKM9
    Secondary Accessions:
    • Q14621
    • Q2M365
    • Q5QPL8
    • Q9BQX6
    • Q9UJE3

    Protein attributes for RALY Gene

    Size:
    306 amino acids
    Molecular mass:
    32463 Da
    Quaternary structure:
    • Identified in the spliceosome C complex.
    Miscellaneous:
    • Autoantigen found in infectious mononucleosis caused by Epstein-Barr virus. An epitope recognized by B-cells, which cross-react with the BKRF1 protein (EBNA-1 nuclear protein) of Epstein-Barr virus has been identified

    Three dimensional structures from OCA and Proteopedia for RALY Gene

    Alternative splice isoforms for RALY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALY Gene

Proteomics data for RALY Gene at MOPED

Post-translational modifications for RALY Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys4, Lys34, Lys44, Lys55, Lys165, Lys191, and Lys216

Other Protein References for RALY Gene

No data available for DME Specific Peptides for RALY Gene

Domains for RALY Gene

Gene Families for RALY Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for RALY Gene

UniProtKB/Swiss-Prot:

RALY_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • Q9UKM9
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.:
    • Q9UKM9
genes like me logo Genes that share domains with RALY: view

Function for RALY Gene

Molecular function for RALY Gene

UniProtKB/Swiss-Prot Function: Probable-RNA binding protein. Could be a heterogeneous nuclear ribonucleoprotein (hnRNP). May be involved in pre-mRNA splicing (By similarity).

Gene Ontology (GO) - Molecular Function for RALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 9376072
GO:0005515 protein binding IPI 22720776
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RALY: view

Phenotypes for RALY Gene

MGI mutant phenotypes for RALY:
inferred from 1 alleles
GenomeRNAi human phenotypes for RALY:
genes like me logo Genes that share phenotypes with RALY: view

miRNA for RALY Gene

miRTarBase miRNAs that target RALY

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RALY Gene

Localization for RALY Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALY Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALY Gene COMPARTMENTS Subcellular localization image for RALY gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22720776
GO:0071013 catalytic step 2 spliceosome IDA 11991638
genes like me logo Genes that share ontologies with RALY: view

Pathways for RALY Gene

SuperPathways for RALY Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome IC 11991638
genes like me logo Genes that share ontologies with RALY: view

No data available for Pathways by source for RALY Gene

Transcripts for RALY Gene

Unigene Clusters for RALY Gene

RNA binding protein, autoantigenic (hnRNP-associated with lethal yellow homolog (mouse)):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALY Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d · 11e ^
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - -
SP6: - -
SP7: - - - - - - - - - -
SP8: - - - - -
SP9: - - -
SP10: - - - - - - -
SP11: - - -
SP12:
SP13:
SP14:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for RALY Gene

GeneLoc Exon Structure for
RALY
ECgene alternative splicing isoforms for
RALY

Expression for RALY Gene

mRNA expression in normal human tissues for RALY Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALY Gene

SOURCE GeneReport for Unigene cluster for RALY Gene Hs.136947

mRNA Expression by UniProt/SwissProt for RALY Gene

Q9UKM9-RALY_HUMAN
Tissue specificity: Expressed in heart, brain, lung, liver, skeletal muscle, kidney and pancreas. Weakly expressed in placenta
genes like me logo Genes that share expressions with RALY: view

Orthologs for RALY Gene

This gene was present in the common ancestor of animals.

Orthologs for RALY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALY 36
  • 98.58 (n)
  • 98.37 (a)
RALY 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALY 36
  • 88.46 (n)
  • 88.34 (a)
RALY 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALY 36
  • 91.24 (n)
  • 90.78 (a)
RALY 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Raly 36
  • 83.99 (n)
  • 85.62 (a)
Raly 16
Raly 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 69 (a)
OneToMany
-- 37
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 26 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Raly 36
  • 85.75 (n)
  • 87.93 (a)
chicken
(Gallus gallus)
Aves RALY 36
  • 74.07 (n)
  • 76.34 (a)
RALY 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALY 37
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20815 36
tropical clawed frog
(Silurana tropicalis)
Amphibia raly 36
  • 73.68 (n)
  • 80.37 (a)
zebrafish
(Danio rerio)
Actinopterygii raly 36
  • 72.17 (n)
  • 82.55 (a)
raly 37
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42458 37
  • 12 (a)
OneToMany
Species with no ortholog for RALY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALY Gene

ENSEMBL:
Gene Tree for RALY (if available)
TreeFam:
Gene Tree for RALY (if available)

Paralogs for RALY Gene

Paralogs for RALY Gene

genes like me logo Genes that share paralogs with RALY: view

Variants for RALY Gene

Sequence variations from dbSNP and Humsavar for RALY Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs909884 -- 34,058,257(-) GAACC(A/C)CTGCA intron-variant
rs932388 -- 34,069,572(-) GTGTG(A/G)GCATC intron-variant
rs1049462 -- 34,080,115(+) CCTGT(C/T)TGCAC utr-variant-3-prime
rs1049469 -- 34,080,132(+) GGCCA(A/G)AGGGT utr-variant-3-prime
rs1054534 -- 34,017,521(-) CACCC(C/G)CTGCA intron-variant

Relevant External Links for RALY Gene

HapMap Linkage Disequilibrium report
RALY

No data available for Structural Variations from Database of Genomic Variants (DGV) for RALY Gene

Disorders for RALY Gene

Relevant External Links for RALY

Genetic Association Database (GAD)
RALY
Human Genome Epidemiology (HuGE) Navigator
RALY
genes like me logo Genes that share disorders with RALY: view

No data available for UniProtKB/Swiss-Prot for RALY Gene

Publications for RALY Gene

  1. The p542 gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ribonucleoprotein. (PMID: 9376072) Rhodes G.H. … Vaughan J.H. (J. Autoimmun. 1997) 3 4 23
  2. Alternative processing of the human and mouse raly genes. (PMID: 10500250) Khrebtukova I. … Michaud E.J. (Biochim. Biophys. Acta 1999) 2 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. (PMID: 11991638) Jurica M.S. … Moore M.J. (RNA 2002) 3 4
  5. Epstein-Barr virus-induced autoimmune responses. I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1. (PMID: 7533788) Vaughan J.H. … Rhodes G.H. (J. Clin. Invest. 1995) 3 4

Products for RALY Gene

Sources for RALY Gene

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