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Aliases for RALGPS2 Gene

Aliases for RALGPS2 Gene

  • Ral GEF With PH Domain And SH3 Binding Motif 2 2 3
  • Ral GEF With PH Domain And SH3-Binding Motif 2 3 4
  • RalA Exchange Factor RalGPS2 3 4
  • Ral-A Exchange Factor RalGPS2 3
  • DJ595C2.1 3

External Ids for RALGPS2 Gene

Previous GeneCards Identifiers for RALGPS2 Gene

  • GC01P175934
  • GC01P175425
  • GC01P176960
  • GC01P149922

Summaries for RALGPS2 Gene

GeneCards Summary for RALGPS2 Gene

RALGPS2 (Ral GEF With PH Domain And SH3 Binding Motif 2) is a Protein Coding gene. Diseases associated with RALGPS2 include alzheimer disease. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGDS.

UniProtKB/Swiss-Prot for RALGPS2 Gene

  • Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGPS2 Gene

Genomics for RALGPS2 Gene

Regulatory Elements for RALGPS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RALGPS2 Gene

Chromosome:
1
Start:
178,725,147 bp from pter
End:
178,921,842 bp from pter
Size:
196,696 bases
Orientation:
Plus strand

Genomic View for RALGPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALGPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGPS2 Gene

Proteins for RALGPS2 Gene

  • Protein details for RALGPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X27-RGPS2_HUMAN
    Recommended name:
    Ras-specific guanine nucleotide-releasing factor RalGPS2
    Protein Accession:
    Q86X27
    Secondary Accessions:
    • B7Z7B1
    • Q5T5Z1
    • Q5VZ67
    • Q9NW78

    Protein attributes for RALGPS2 Gene

    Size:
    583 amino acids
    Molecular mass:
    65167 Da
    Quaternary structure:
    • Interacts with the SH3 domains of GRB2 and PLCG1. Interacts with RALA.
    SequenceCaution:
    • Sequence=CAH71098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21919.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21925.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGPS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGPS2 Gene

Proteomics data for RALGPS2 Gene at MOPED

Post-translational modifications for RALGPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGPS2 Gene

Antibody Products

No data available for DME Specific Peptides for RALGPS2 Gene

Domains & Families for RALGPS2 Gene

Gene Families for RALGPS2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86X27

UniProtKB/Swiss-Prot:

RGPS2_HUMAN :
  • The PH domain mediates binding to phosphatidylinositol 4,5-bisphosphate.
Domain:
  • The PH domain mediates binding to phosphatidylinositol 4,5-bisphosphate.
  • Contains 1 PH domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RALGPS2: view

Function for RALGPS2 Gene

Molecular function for RALGPS2 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion (By similarity).

Gene Ontology (GO) - Molecular Function for RALGPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with RALGPS2: view
genes like me logo Genes that share phenotypes with RALGPS2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGPS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RALGPS2 Gene

Localization for RALGPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALGPS2 Gene

Cytoplasm. Cell membrane. Note=Associates with membranes through the PH domain. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGPS2 Gene COMPARTMENTS Subcellular localization image for RALGPS2 gene
Compartment Confidence
nucleus 3
plasma membrane 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RALGPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RALGPS2: view

Pathways & Interactions for RALGPS2 Gene

SuperPathways for RALGPS2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RALGPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0032485 regulation of Ral protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RALGPS2: view

No data available for Pathways by source and SIGNOR curated interactions for RALGPS2 Gene

Drugs & Compounds for RALGPS2 Gene

(3) Drugs for RALGPS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RALGPS2: view

Transcripts for RALGPS2 Gene

Unigene Clusters for RALGPS2 Gene

Ral GEF with PH domain and SH3 binding motif 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGPS2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALGPS2 Gene

No ASD Table

Relevant External Links for RALGPS2 Gene

GeneLoc Exon Structure for
RALGPS2
ECgene alternative splicing isoforms for
RALGPS2

Expression for RALGPS2 Gene

mRNA expression in normal human tissues for RALGPS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALGPS2 Gene

This gene is overexpressed in Testis (x4.4).

Protein differential expression in normal tissues from HIPED for RALGPS2 Gene

This gene is overexpressed in Testis (37.6) and Blymphocyte (20.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGPS2 Gene



SOURCE GeneReport for Unigene cluster for RALGPS2 Gene Hs.632485

genes like me logo Genes that share expression patterns with RALGPS2: view

Protein tissue co-expression partners for RALGPS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for RALGPS2 Gene

Orthologs for RALGPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RALGPS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RALGPS2 35
  • 94.79 (n)
  • 98.92 (a)
RALGPS2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGPS2 35
  • 95.08 (n)
  • 99.66 (a)
RALGPS2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralgps2 35
  • 89.02 (n)
  • 97.6 (a)
Ralgps2 16
Ralgps2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RALGPS2 35
  • 99.77 (n)
  • 99.66 (a)
RALGPS2 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALGPS2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALGPS2 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves RALGPS2 35
  • 85.31 (n)
  • 95.88 (a)
RALGPS1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGPS2 36
  • 96 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgps2 35
  • 79.27 (n)
  • 90.03 (a)
zebrafish
(Danio rerio)
Actinopterygii ralgps2 35
  • 71.61 (n)
  • 83.17 (a)
zgc63650 35
ralgps2 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7645 35
fruit fly
(Drosophila melanogaster)
Insecta CG5522 36
  • 34 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC25 36
  • 6 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5548 36
  • 46 (a)
OneToMany
Species with no ortholog for RALGPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALGPS2 Gene

ENSEMBL:
Gene Tree for RALGPS2 (if available)
TreeFam:
Gene Tree for RALGPS2 (if available)

Paralogs for RALGPS2 Gene

Paralogs for RALGPS2 Gene

(1) SIMAP similar genes for RALGPS2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RALGPS2: view

Variants for RALGPS2 Gene

Sequence variations from dbSNP and Humsavar for RALGPS2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7366 -- 178,921,650(+) ACTCT(A/G)ATGAT utr-variant-3-prime
rs7970 -- 178,921,724(-) AAAAA(A/G)AAACA utr-variant-3-prime
rs9515 -- 178,919,721(+) CCATT(A/G)GCTTT utr-variant-3-prime
rs502167 -- 178,837,001(+) gtctc(A/G)aactc intron-variant
rs598880 -- 178,814,754(-) agaga(C/T)gaggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGPS2 Gene

Variant ID Type Subtype PubMed ID
nsv525444 CNV Loss 19592680
nsv466206 CNV Gain 19166990
nsv470748 CNV Gain 18288195
nsv825498 CNV Loss 20364138
nsv872572 CNV Loss 21882294
nsv3710 CNV Insertion 18451855

Variation tolerance for RALGPS2 Gene

Residual Variation Intolerance Score: 19.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALGPS2 Gene

HapMap Linkage Disequilibrium report
RALGPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALGPS2 Gene

Disorders for RALGPS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALGPS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association

UniProtKB/Swiss-Prot

RGPS2_HUMAN
  • Note=RALGPS2 is a potential candidate gene for susceptibility to Alzheimer disease linked to 1q24. {ECO:0000269 PubMed:17564960}.

Relevant External Links for RALGPS2

Genetic Association Database (GAD)
RALGPS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALGPS2
genes like me logo Genes that share disorders with RALGPS2: view

No data available for Genatlas for RALGPS2 Gene

Publications for RALGPS2 Gene

  1. A growing family of guanine nucleotide exchange factors is responsible for activation of Ras-family GTPases. (PMID: 12102558) Quilliam L.A. … Castro A.F. (Prog. Nucleic Acid Res. Mol. Biol. 2002) 2 67
  2. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. (PMID: 10747847) Rebhun J.F. … Quilliam L.A. (J. Biol. Chem. 2000) 2 67
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67
  4. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 67
  5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 67

Products for RALGPS2 Gene

Sources for RALGPS2 Gene

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