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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RALGPS1 Gene

protein-coding   GIFtS: 53
GCID: GC09P129679

Ral GEF With PH Domain And SH3 Binding Motif 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ral GEF With PH Domain And SH3 Binding Motif 11 2     RalGEF 22 3
Ral GEF With PH Domain And SH3-Binding Motif 12 3     RALGPS1A2
Ral Guanine Nucleotide Exchange Factor 22 3     Ral Guanine Nucleotide Exchange Factor RalGPS1A2
RalA Exchange Factor RalGPS12 3     Ras-Specific Guanine Nucleotide-Releasing Factor RalGPS12
RALGEF22 3     KIAA03513

External Ids:    HGNC: 168511   Entrez Gene: 96492   Ensembl: ENSG000001368287   OMIM: 6144445   UniProtKB: Q5JS133   

Export aliases for RALGPS1 gene to outside databases

Previous GC identifers: GC09U900571 GC09P126757 GC09P128716 GC09P099292


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RALGPS1 Gene: 
RALGPS1 (Ral GEF with PH domain and SH3 binding motif 1) is a protein-coding gene. Diseases associated with RALGPS1 include prader-willi syndrome, and intrahepatic cholangiocarcinoma, and among its related super-pathways are Cytoskeleton remodeling RalA regulation pathway. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: RGPS1_HUMAN, Q5JS13
Function: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal
organization (By similarity). Guanine nucleotide exchange factor for




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RALGPS1 gene promoter:
         GR   Tal-1   E47   CBF-C   CBF-B   CBF-A   CP1C   GR-alpha   CP1A   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRALGPS1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RALGPS1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGPS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

RALGPS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGPS1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P129679:  view genomic region     (about GC identifiers)

Start:
129,677,053 bp from pter      End:
129,985,445 bp from pter
Size:
308,393 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RGPS1_HUMAN, Q5JS13 (See protein sequence)
Recommended Name: Ras-specific guanine nucleotide-releasing factor RalGPS1  
Size: 557 amino acids; 62133 Da
Subunit: Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC
Subcellular location: Cytoplasm. Cell membrane. Note=Associates with membranes through the PH domain
Sequence caution: Sequence=AAH19329.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA20808.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for RALGPS1:
3QXL (3D)    
Secondary accessions: B4DR86 E9PBQ5 O15059 Q5JT60 Q5JT65 Q5JUG5 Q8N4S6 Q8N5H4 Q8WUV7 Q9NZ16
Alternative splicing: 7 isoforms:  Q5JS13-1   Q5JS13-2   Q5JS13-3   Q5JS13-4   Q5JS13-5   Q5JS13-6   Q5JS13-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGPS1: NX_Q5JS13

Explore proteomics data for RALGPS1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5JS13

  • RALGPS1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RALGPS1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001177657.1  NP_001177658.1  NP_001177659.1  NP_055451.1  

    ENSEMBL proteins: 
     ENSP00000259351   ENSP00000377590   ENSP00000377579   ENSP00000317149   ENSP00000362535  
     ENSP00000362533   ENSP00000404021   ENSP00000415630  

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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IEA--

    RALGPS1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing

    5 InterPro protein domains:
     IPR008937 Ras_GEF
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25

    Graphical View of Domain Structure for InterPro Entry Q5JS13

    ProtoNet protein and cluster: Q5JS13

    UniProtKB/Swiss-Prot: RGPS1_HUMAN, Q5JS13
    Domain: The PH domain mediates binding to membranes. It is required for efficient GEF activity
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GEF domain


    RALGPS1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGPS1_HUMAN, Q5JS13
    Function: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal
    organization (By similarity). Guanine nucleotide exchange factor for

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity NAS10747847
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0008321Ral guanyl-nucleotide exchange factor activity IDA10747847
         
    RALGPS1 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RALGPS1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeleton remodeling RalA regulation pathway
    Cytoskeleton remodeling RalA regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RALGPS1
        Cytoskeleton remodeling RalA regulation pathway


    1 GeneGo (Thomson Reuters) Pathway for RALGPS1
        Cytoskeleton remodeling RalA regulation pathway



    RALGPS1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RALGPS1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for RALGPS1 (Q5JS132, 3 ENSP000002593514) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GRB2P629933, ENSP000003390074I2D: score=3 STRING: ENSP00000339007
    NCK1P163333, ENSP000002889864I2D: score=1 STRING: ENSP00000288986
    RALAP112333, ENSP000000052574I2D: score=3 STRING: ENSP00000005257
    C2orf88ENSP000003451074STRING: ENSP00000345107
    --P310162MINT-8105125
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0032485regulation of Ral protein signal transduction IDA10747847
    GO:0035556intracellular signal transduction NAS10747847

    RALGPS1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RALGPS1 (RGPS1)

    3 HMDB Compounds for RALGPS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about RALGPS1 / RGPS1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RALGPS1 gene (4 alternative transcripts): 
    NM_001190728.1  NM_001190729.1  NM_001190730.1  NM_014636.2  

    Unigene Cluster for RALGPS1:

    Ral GEF with PH domain and SH3 binding motif 1
    Hs.432842  [show with all ESTs]
    Unigene Representative Sequence: NM_014636
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259351(uc004bqo.2) ENST00000394022(uc011mab.2) ENST00000373439
    ENST00000394011 ENST00000319107 ENST00000472427 ENST00000373436(uc022bno.1)
    ENST00000480993 ENST00000373434(uc004bqq.4) ENST00000477700 ENST00000467325
    ENST00000438723 ENST00000471643 ENST00000424082(uc011mac.2)
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    Additional mRNA sequence: 

    AB002349.1 AF221098.1 AK023463.1 AK299149.1 BC019329.1 BC032372.1 BC033708.1 BX648170.1 

    16 DOTS entries:

    DT.92420794  DT.116753  DT.100777604  DT.91682117  DT.97774561  DT.95170280  DT.95170282  DT.100022263 
    DT.97775126  DT.97810936  DT.75100778  DT.116756  DT.70100771  DT.121163424  DT.91989809  DT.102830316 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for RALGPS1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                          -                       -     -     -     -     -                             -                       -     -                     
    SP2:                                                  -     -     -     -     -                             -                       -     -           -     -   
    SP3:                                                  -     -     -     -     -                             -                       -                           
    SP4:                                                  -     -     -     -     -                             -                                                   
    SP5:                                                                                                                                -     -           -     -   

    ExUns: 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26
    SP1:  -                                   -         
    SP2:                    -                           
    SP3:                                                
    SP4:                                                
    SP5:                                      -         


    ECgene alternative splicing isoforms for RALGPS1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RALGPS1 expression in normal human tissues (normalized intensities)      RALGPS1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGTTCTTTC
    RALGPS1 Expression
    About this image


    RALGPS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Positive Thymocytes Thymus
     
     Brain (Nervous System)
             neocortex   
     
     Epidermis (Integumentary System)
     
     Dermis (Integumentary System)

    See RALGPS1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RALGPS1

    SOURCE GeneReport for Unigene cluster: Hs.432842

    UniProtKB/Swiss-Prot: RGPS1_HUMAN, Q5JS13
    Tissue specificity: Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas,
    prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in
    heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RALGPS1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgps11 , 5 Ral GEF with PH domain and SH3 binding motif 11, 5 91.14(n)1
    96.77(a)1
      2 (22.25 cM)5
    2413081  NM_175211.41  NP_780420.11 
     331334215 
    chicken
    (Gallus gallus)
    Aves RALGPS11 Ral GEF with PH domain and SH3 binding motif 1 79.1(n)
    88.11(a)
      417089  XM_003642301.1  XP_003642349.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALGPS16
    Ral GEF with PH domain and SH3 binding motif 1
    86(a)
    1 ↔ 1
    GL343502.1(389387-567782)
    zebrafish
    (Danio rerio)
    Actinopterygii ralgps11 Ral GEF with PH domain and SH3 binding motif 1 70.84(n)
    76.95(a)
      100101642  NM_001100146.1  NP_001093616.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55221 CG5522 50.51(n)
    45.75(a)
      36881  NM_166196.1  NP_725616.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC256
    Membrane bound guanine nucleotide exchange factor ...
    5(a)
    1 → many
    XII(752224-756993)


    ENSEMBL Gene Tree for RALGPS1 (if available)
    TreeFam Gene Tree for RALGPS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RALGPS1 gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGDS2  RGL42  RGL12  
    2 SIMAP similar genes for RALGPS1 using alignment to 3 protein entries:     RGPS1_HUMAN (see all proteins):
    BCR-ABL1    RALGPS2

    RALGPS1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4700 SNPs in RALGPS1 are shown (see all 4700)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1391200131,2
    --129675253(+) GTGTGA/TCTGGC 3 -- us2k10--------
    rs117916341,2
    C,F,H--129675383(+) tccgtT/Ctcaaa 3 -- us2k13Minor allele frequency- C:0.33NA 6
    rs1508561121,2
    --129675457(+) GTACAC/GAGCTT 3 -- us2k10--------
    rs2022395261,2
    C--129675525(+) TTTTT-/TGGGAC 3 -- us2k10--------
    rs1170377591,2
    F--129675531(+) TTTTTT/CTTTTT 3 -- us2k11Minor allele frequency- C:0.04NA 120
    rs1846142321,2
    C--129675537(+) TTTTTG/TGGGAC 3 -- us2k10--------
    rs1869559491,2
    --129675574(+) GAGTGC/TAGTGG 3 -- us2k10--------
    rs1913870941,2
    --129675610(+) CGCCTC/TCCAAG 3 -- us2k10--------
    rs1154067021,2
    C,F--129675751(+) TTTTTT/CGAGAC 3 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1836099481,2
    --129675766(+) TATCGC/GTCTGT 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALGPS1 (129677053 - 129927053 bp, first 250kb of RALGPS1)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for RALGPS1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6721CNV Insertion18451855
    nsv517522CNV Loss19592680
    nsv893849CNV Gain21882294
    nsv825086CNV Gain20364138
    nsv831726CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614444    OMIM disorders: --

    4 diseases for RALGPS1:    About MalaCards
    prader-willi syndrome    intrahepatic cholangiocarcinoma    cholangiocarcinoma    prostatitis


    RALGPS1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RALGPS1
    Human Genome Epidemiology (HuGE) Navigator: RALGPS1 (4 documents)

    Export disorders for RALGPS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RALGPS1 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with RALGPS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of a new family of guanine nucleotide exchange factors for the ras-related GTPase Ral. (PubMed id 10747847)1, 2, 3 Rebhun J.F....Quilliam L.A. (2000)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Structural study of the Cdc25 domain from Ral-specific guanine- nucleotide exchange factor RalGPS1a. (PubMed id 21494904)1, 2 Peng W.... Rao Z. (2011)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral. (PubMed id 10889189)1, 2 de Bruyn K.M....Bos J.L. (2000)
    7. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    10. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9649 HGNC: 16851 Ensembl:ENSG00000136828 euGenes: HUgn9649 ECgene: RALGPS1
    H-InvDB: RALGPS1

    (According to HUGE)
    About This Section
    HUGE: KIAA0351

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RALGPS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RALGPS1 gene:
    Search GeneIP for patents involving RALGPS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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