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RALGDS Gene

protein-coding   GIFtS: 64
GCID: GC09M135973

Ral Guanine Nucleotide Dissociation Stimulator

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ral Guanine Nucleotide Dissociation Stimulator1 2     RGDS2
Ral Guanine Nucleotide Exchange Factor2 3     KIAA13083
RGF2 3     RalGDS3
RalGEF2 3     

External Ids:    HGNC: 98421   Entrez Gene: 59002   Ensembl: ENSG000001602717   OMIM: 6016195   UniProtKB: Q129673   

Export aliases for RALGDS gene to outside databases

Previous GC identifers: GC09U990066 GC09M127529 GC09M129327 GC09M131249 GC09M133002 GC09M134962 GC09M105466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RALGDS Gene:
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of
Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.(supplied
by OMIM, Nov 2010)

GeneCards Summary for RALGDS Gene:
RALGDS (ral guanine nucleotide dissociation stimulator) is a protein-coding gene. GO annotations related to this gene include small GTPase regulator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967
Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding
and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

Gene Wiki entry for RALGDS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the RALGDS gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   STAT5A   HNF-4alpha1   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RALGDS promoter sequence
   Search Chromatin IP Primers for RALGDS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALGDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.3

RALGDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGDS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135973:  view genomic region     (about GC identifiers)

Start:
135,973,107 bp from pter      End:
136,039,301 bp from pter
Size:
66,195 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator  
Size: 914 amino acids; 100607 Da
Subunit: Interacts with RIT1 and RIT2 (By similarity)
4 PDB 3D structures from and Proteopedia for RALGDS:
1RAX (3D)        2B3A (3D)        2RGF (3D)        3KH0 (3D)    
Secondary accessions: Q5T7V4 Q6KH11 Q9HAX7 Q9HAY1 Q9HCT1 Q9P2N8
Alternative splicing: 3 isoforms:  Q12967-1   Q12967-2   Q12967-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGDS: NX_Q12967

Explore proteomics data for RALGDS at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RALGDS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001035827.1  NP_001258703.1  NP_001258704.1  NP_001258705.1  NP_006257.1  

    ENSEMBL proteins: 
     ENSP00000361120   ENSP00000361117   ENSP00000376867   ENSP00000391814   ENSP00000437518  
     ENSP00000361132   ENSP00000376864  
    Reactome Protein details: Q12967

    RALGDS Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RALGDS

     
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    LSBio Antibodies in human, mouse, rat for RALGDS

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    Cloud-Clone Corp. ELISAs for RALGDS
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    Search eBioscience for ELISAs for RALGDS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR015758 RalGDS

    Graphical View of Domain Structure for InterPro Entry Q12967

    ProtoNet protein and cluster: Q12967

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000463 Cytosolic fatty-acid binding protein
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967
    Domain: The Ras-associating domain interacts with Ras
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    Find genes that share domains with RALGDS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNDS_HUMAN, Q12967
    Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding
    and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

         Genatlas biochemistry entry for RALGDS:
    Ral guanine nucleotide dissociation stimulator,related protein,115kDa,involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity NAS9365783
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with RALGDS           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RALGDS:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ralgds):
     homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with RALGDS           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ralgdstm1Cjm for RALGDS

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALGDS
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RALGDS

    miRNA
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    miRTarBase miRNAs that target RALGDS:
    hsa-mir-183-5p (MIRT047157), hsa-mir-615-3p (MIRT039756), hsa-mir-335-5p (MIRT017310), hsa-mir-186-5p (MIRT044953)

    Block miRNA regulation of human, mouse, rat RALGDS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RALGDS (see all 30):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-30d hsa-miR-302e hsa-miR-449a hsa-miR-520a-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRALGDS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RALGDS
    Predesigned siRNA for gene silencing in human, mouse, rat RALGDS

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): RALGDS (NM_006266)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGDS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    plasma membrane2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    Find genes that share ontologies with RALGDS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RALGDS About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Signalling to ERKs
    Signalling to ERKs0.73
    p38MAPK events0.00
    Signalling to RAS0.73
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    4GPCR Pathway
    Ras Pathway0.73
    5Akt Signaling
    p38 Signaling0.60


    Find genes that share SuperPaths with RALGDS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RALGDS
        FGF Pathway
    Molecular Mechanisms of Cancer
    p38 Signaling
    Phospholipase-C Pathway
    Ras Pathway

    Selected GeneGo (Thomson Reuters) Pathways for RALGDS (see all 7)
        G-protein signaling H-RAS regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Rap1A regulation pathway
    Cytoskeleton remodeling RalB regulation pathway
    G-protein signaling K-RAS regulation pathway

    3 BioSystems Pathways for RALGDS
        EGFR1 Signaling Pathway
    TSH signaling pathway
    ErbB1 downstream signaling

    1 Reactome Pathway for RALGDS
        p38MAPK events


    5 Kegg Pathways  (Kegg details for RALGDS):
        Ras signaling pathway
    Rap1 signaling pathway
    Pathways in cancer
    Colorectal cancer
    Pancreatic cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RALGDS
    Interactions:

        GeneGlobe Interaction Network for RALGDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RALGDS (Q129671, 2, 3 ENSP000003611204) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAP1BP612241, 2, ENSP000002505594EBI-365861,EBI-358143 MINT-8380709 STRING: ENSP00000250559
    HRASP011123, ENSP000003098454I2D: score=7 STRING: ENSP00000309845
    RAP1AP628343, ENSP000003487864I2D: score=5 STRING: ENSP00000348786
    RIT2Q995783, ENSP000003218054I2D: score=3 STRING: ENSP00000321805
    ARRB1P494073, ENSP000003771414I2D: score=2 STRING: ENSP00000377141
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0050790regulation of catalytic activity NAS9365783

    Find genes that share ontologies with RALGDS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALGDS (GNDS)

    1 HMDB Compound for RALGDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for RALGDS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62.5 3 10022812 (2), 8637701 (1)
    gtp 56.4 5 17295314 (1), 8637701 (1), 9230043 (1), 19776012 (1) (see all 5)
    guanine 53.9 2 20118982 (1), 17315921 (1)
    phosphatidylinositol 52.8 13 8643674 (1), 10733581 (1), 20118982 (1), 12829429 (1) (see all 9)
    phosphoinositide 13.9 2 16691442 (1), 10866657 (1)



    Find genes that share compounds with RALGDS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RALGDS gene (5 alternative transcripts): 
    NM_001042368.2  NM_001271774.1  NM_001271775.1  NM_001271776.1  NM_006266.3  

    Unigene Cluster for RALGDS:

    Ral guanine nucleotide dissociation stimulator
    Hs.106185  [show with all ESTs]
    Unigene Representative Sequence: AB037729
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482648 ENST00000469972(uc004ccv.1 uc004ccu.1) ENST00000493438(uc004ccp.3)
    ENST00000372050(uc004cco.3) ENST00000372047(uc004ccn.3 uc004ccq.3 uc011mcv.2)
    ENST00000393160(uc004ccs.3) ENST00000498797 ENST00000495621 ENST00000477660
    ENST00000424572 ENST00000471109 ENST00000493067 ENST00000460587 ENST00000542690(uc011mcw.2)
    ENST00000372062 ENST00000393157(uc004ccr.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RALGDS (see all 30):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-30d hsa-miR-302e hsa-miR-449a hsa-miR-520a-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRALGDS 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): RALGDS (NM_006266)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat RALGDS
      QuantiFast Probe-based Assays in human, mouse, rat RALGDS

    Additional mRNA sequence: 

    AB037729.1 AF027169.1 AF295773.1 AK000242.1 AK024575.1 AK056462.1 AK074114.1 AK090450.1 
    AK127524.1 AK293997.1 AK301470.1 BC021581.1 BC033198.1 BC040737.1 BC059362.1 BC150504.1 
    U14417.1 

    Selected DOTS entries (see all 26):

    DT.75173495  DT.101961836  DT.100037283  DT.100795494  DT.100802244  DT.100795495  DT.100688537  DT.101959065 
    DT.121187273  DT.101983852  DT.92439161  DT.92439154  DT.95157053  DT.95157064  DT.121187301  DT.121187312 
    DT.95157086  DT.121187315  DT.40222114  DT.433942  DT.92020609  DT.95157052  DT.95157060  DT.95157061 

    Selected AceView cDNA sequences (see all 281):

    BM741401 BC033198 BF739937 AF295773 BE885116 BM747976 BM756793 BF432516 
    BM919894 U14417 BU175538 BE048028 AI421559 AI419183 BQ023755 BM745178 
    BM705350 BQ955043 AI935791 BI491221 BF593805 AI539258 BQ025059 AI859194 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RALGDS (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
    SP1:                          -                       -                                                                 -     -     -                       -   
    SP2:                          -                                                                                         -     -     -                       -   
    SP3:                          -                       -                                                                 -     -     -                       -   
    SP4:                                                                                                                    -     -     -                       -   
    SP5:                                                                                                                    -     -     -                       -   

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
    SP1:        -                                         -           -           -               
    SP2:        -                                         -           -           -               
    SP3:        -                                         -                       -               
    SP4:        -                                         -                                       
    SP5:        -                                                                                 


    ECgene alternative splicing isoforms for RALGDS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RALGDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGACGGGG
    RALGDS Expression
    About this image


    RALGDS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
     
     Gall Bladder (Hepatobiliary System)
    RALGDS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALGDS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.106185
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RALGDS gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgds1 , 5 ral guanine nucleotide dissociation stimulator1, 5 85.33(n)1
    87.79(a)1
      2 (19.38 cM)5
    197301  NM_001145836.11  NP_001139308.11 
     285131255 
    chicken
    (Gallus gallus)
    Aves RALGDS1 ral guanine nucleotide dissociation stimulator 78.82(n)
    76.68(a)
      427758  XM_004945929.1  XP_004945986.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALGDS6
    ral guanine nucleotide dissociation stimulator
    64(a)
    1 ↔ 1
    GL344285.1(41627-54316)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.288642 Xenopus laevis transcribed sequence with moderate similarity more 76.14(n)    BX843353.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab2l2 ras-associated protein 76.19(n)   65227  AF202722.1 


    ENSEMBL Gene Tree for RALGDS (if available)
    TreeFam Gene Tree for RALGDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RALGDS gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGPS12  RGL12  RGL42  
    9 SIMAP similar genes for RALGDS using alignment to 9 protein entries:     GNDS_HUMAN (see all proteins):
    FLJ00371    GBGT1    FLJ00185    DKFZp686C2469    RGL1    HKE1.5
    RGL4    RGL2    FLJ00153

    Find genes that share paralogs with RALGDS           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RALGDS
    PGOHUM00000238790 PGOHUM00000236345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RALGDS (see all 1350)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358224
    A colorectal cancer sample4--see VAR_0358222 R L mis40--------
    rs1162847671,2
    C,F--135972612(+) CCTCCC/TGAATA 5 -- int11Minor allele frequency- T:0.08WA 118
    rs1492744711,2
    C--135972637(+) TGCCTA/GGCACC 5 -- int10--------
    rs1435210411,2
    --135972740(+) CCTTGG/TCCTCC 5 -- int10--------
    rs1863446591,2
    --135972778(+) CACCAC/TGCCTG 5 -- int10--------
    rs1153307691,2
    F--135972988(+) TTTTCC/TTGTGC 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1480072741,2
    --135973045(+) ATGTGA/GGAGTC 5 -- int10--------
    rs1918874811,2
    --135973244(+) CACCCA/CACCCC 5 -- ut310--------
    rs1815017641,2
    --135973250(+) ACCCCC/GACCCC 5 -- ut310--------
    rs1172429411,2
    C,F--135973281(+) CCCCCG/ATCTTG 5 -- ut311Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for RALGDS (135973107 - 136039301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RALGDS (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1320546CNV Deletion17803354
    esv2739149CNV Deletion23290073
    esv1008406CNV Deletion20482838
    esv2672482CNV Deletion23128226
    esv2739138CNV Deletion23290073
    nsv894036CNV Loss21882294
    nsv466610CNV Loss19166990
    nsv894034CNV Loss21882294
    nsv508565CNV Loss20534489
    dgv8320n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): RALGDS
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RALGDS
    DNA2.0 Custom Variant and Variant Library Synthesis for RALGDS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601619    OMIM disorders: --


    Find genes that share disorders with RALGDS           About GenesLikeMe

    3 Novoseek inferred disease relationships for RALGDS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 1.89 2 15766656 (1), 17568777 (1)
    metastasis 0 4 11486034 (4)
    tumors 0 4 11486034 (1), 15766656 (1)


    Export disorders for RALGDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RALGDS gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with RALGDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. (PubMed id 7972015)1, 2, 3 Hofer F.... Martin G.S. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. (PubMed id 9365783)1, 2 Humphrey D.... Kwiatkowski D.J. (Ann. Hum. Genet. 1997)
    4. Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. (PubMed id 9302994)1, 2 Geyer M.... Kalbitzer H.R. (Nat. Struct. Biol. 1997)
    5. PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. (PubMed id 11889038)1, 9 Tian X....Feig L.A. (EMBO J. 2002)
    6. Structure characterization of human RalGDS gene, and the identification of its novel variant. (PubMed id 11455956)1, 9 Zheng Q....Zhao S. (Mol. Biol. Rep. 2000)
    7. Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS. (PubMed id 9516482)1, 9 Shirouzu M....Yokoyama S. (J. Biol. Chem. 1998)
    8. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. (PubMed id 18417737)1, 9 Rondaij M.G....Voorberg J. (Blood 2008)
    9. Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. (PubMed id 11840339)1, 9 RamA-rez de Molina A....Lacal J.C. (Oncogene 2002)
    10. RalA functions as an indispensable signal mediator for the nutrient-sensing system. (PubMed id 18948269)1, 9 Maehama T....Hanada K. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5900 HGNC: 9842 AceView: RALGDS Ensembl:ENSG00000160271 euGenes: HUgn5900
    ECgene: RALGDS Kegg: 5900 H-InvDB: RALGDS

    (According to HUGE)
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    HUGE: KIAA1308

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RALGDS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALGDS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RALGDS gene:
    Search GeneIP for patents involving RALGDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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