RALGDS Gene
protein-coding GIFtS: 62
GCID: GC09M135973
|
|
ral guanine nucleotide dissociation stimulator
| |
Aliases
for RALGDS gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ral Guanine Nucleotide Dissociation Stimulator1 2 | | Ral Guanine Nucleotide Exchange Factor2 3 | | RGF1 2 3 | | KIAA13083 | | RalGEF1 2 3 | | RalGDS3 | | RGDS1 2 | | |
Export aliases for RALGDS gene to outside databasesPrevious GC identifers: GC09U990066 GC09M127529 GC09M129327 GC09M131249 GC09M133002 GC09M134962 GC09M105466 |
Summaries
for RALGDS gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RALGDS:
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-relatedGTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.(supplied by OMIM, Nov2010)
UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding andactivation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap
Gene Wiki entry for RALGDS
|
Genomic Views
for RALGDS gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RALGDS gene promoter:
COUP-TF1 FOXF2 COUP HNF-4alpha2 STAT5A HNF-4alpha1 COUP-TF STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RALGDS
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGDS |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.3 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34.3RALGDS Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M135973: view genomic region
(about GC identifiers)
Start:
|
135,973,107 bp from pter |
End:
|
136,039,301 bp from pter |
Size:
|
66,195 bases |
Orientation:
|
minus strand |
|
Proteins
for RALGDS gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967 (See
protein sequence)Recommended Name: Ral guanine nucleotide dissociation stimulator Size: 914 amino acids; 100607 Da
Subunit: Interacts with RIT1 and RIT2 (By similarity)
4 PDB 3D structures from  and Proteopedia  for RALGDS:1RAX (3D)
2B3A (3D)
2RGF (3D)
3KH0 (3D)
Secondary accessions: Q5T7V4 Q6KH11 Q9HAX7 Q9HAY1 Q9HCT1 Q9P2N8Alternative splicing: 3 isoforms: Q12967-1 Q12967-2 Q12967-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RALGDS: NX_Q12967
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12967
RALGDS Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001035827.1 NP_001258703.1 NP_001258704.1 NP_001258705.1 NP_006257.1
ENSEMBL proteins: ENSP00000361120 ENSP00000361117 ENSP00000376867 ENSP00000391814 ENSP00000437518 ENSP00000361132 ENSP00000376864 Reactome Protein details: Q12967
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
RALGDS for ontologies About GeneDecksing
RALGDS Antibody Products:
Assay Products for RALGDS: |
Protein
Domains /
Families
for RALGDS gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RALGDS for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q12967ProtoNet protein and cluster: Q12967 3 Blocks protein families: IPB000159 RA domain IPB000463 Cytosolic fatty-acid binding protein IPB001895 Guanine-nucleotide dissociation stimulator CDC25
UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967Domain: The Ras-associating domain interacts with RasSimilarity: Contains 1 N-terminal Ras-GEF domainSimilarity: Contains 1 Ras-associating domainSimilarity: Contains 1 Ras-GEF domain |
Function
for RALGDS gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding andactivation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap Genatlas biochemistry entry for RALGDS:Ral guanine nucleotide dissociation stimulator,related protein,115kDa,involved in signal transduction
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RALGDS (NM_006266) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RALGDS | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGDS |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGDS |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005083 | small GTPase regulator activity |
NAS | 9365783 | | GO:0005085 | guanyl-nucleotide exchange factor activity |
IEA | -- |
RALGDS for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for RALGDS:
Animal Models:
Mouse knock-out Ralgdstm1Cjm for RALGDS
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ralgds):
RALGDS for phenotypes About GeneDecksing
|
Pathways & Interactions
for RALGDS gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling K-RAS regulation pathway | | | 2 | Cytoskeleton remodeling_RalB regulation pathway | | | 3 | Signalling to RAS | | | 4 | G-protein signaling N-RAS regulation pathway | | | 5 | G-protein signaling Rap1A regulation pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for RALGDS (see all 7)
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RALGDS
5/7  GeneGo (Thomson Reuters) Pathways for RALGDS (see all 7)
3  BioSystems Pathways for RALGDS
5/6 
Reactome Pathways for RALGDS (see all 6)
3 
Kegg Pathways (Kegg details for RALGDS):
RALGDS for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RALGDS
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for RALGDS (Q129672, 3 ENSP000003611204) via UniProtKB, MINT, STRING, and/or I2D (see all 38)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
-- | -- | | GO:0007265 | Ras protein signal transduction |
TAS | -- | | GO:0048011 | nerve growth factor receptor signaling pathway |
TAS | -- | | GO:0051056 | regulation of small GTPase mediated signal transduction |
IEA | -- |
RALGDS for ontologies About GeneDecksing
|
Drugs & Compounds
for RALGDS gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RALGDS for compounds About GeneDecksing
 Browse Tocris compounds for RALGDS
1 HMDB Compound for RALGDS About this table
5 Novoseek chemical compound relationships for RALGDS gene About this table
Search CenterWatch for drugs/clinical trials and news about RALGDS / GNDS
|
Transcripts
for RALGDS gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RALGDS gene (5 alternative transcripts): NM_001042368.2 NM_001271774.1 NM_001271775.1 NM_001271776.1 NM_006266.3 Unigene Cluster for RALGDS: Ral guanine nucleotide dissociation stimulator Hs.106185 [show with all ESTs]Unigene Representative Sequence: AB03772916 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000482648 ENST00000469972(uc004ccv.1 uc004ccu.1) ENST00000493438(uc004ccp.3)
ENST00000372050(uc004cco.3) ENST00000372047(uc004ccn.3 uc004ccq.3 uc011mcv.2)
ENST00000393160(uc004ccs.3) ENST00000498797 ENST00000495621 ENST00000477660
ENST00000424572 ENST00000471109 ENST00000493067 ENST00000460587 ENST00000542690(uc011mcw.2)
ENST00000372062 ENST00000393157(uc004ccr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RALGDS (NM_006266) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RALGDS | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGDS |
Additional cDNA sequence: AB037729.1 AF027169.1 AF295773.1 AK000242.1 AK024575.1 AK056462.1 AK074114.1 AK090450.1 AK127524.1 AK293997.1 AK301470.1 BC021581.1 BC033198.1 BC040737.1 BC059362.1 BC150504.1 U14417.1 24/26 DOTS entries (see all 26): DT.75173495 DT.101961836 DT.100037283 DT.100795494 DT.100802244 DT.100795495 DT.100688537 DT.101959065 DT.121187273 DT.101983852 DT.92439161 DT.92439154 DT.95157053 DT.95157064 DT.121187301 DT.121187312 DT.95157086 DT.121187315 DT.40222114 DT.433942 DT.92020609 DT.95157052 DT.95157060 DT.95157061 24/281 AceView cDNA sequences (see all 281): BE735840 F03268 BF739937 CA311028 AF027169 BM927290 BM908907 AI702044 AA985516 BM741447 BE502039 CB113600 BQ668829 CD107014 BQ955043 AW083177 AI859194 BM705350 T12586 BF593805 AI540261 BQ023755 BQ025059 U14417
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RALGDS (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13a | · | 13b | · | 13c | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | - | |
| ExUns: | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | · | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | |
| SP2: | | | - | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | |
| SP3: | | | - | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | |
| SP4: | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RALGDS
|
Expression
for RALGDS gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RALGDS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGACGGGG
About this image
See RALGDS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RALGDS
SOURCE GeneReport for Unigene cluster: Hs.106185
SABiosciences Custom PCR Arrays for RALGDS
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RALGDS
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RALGDS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALGDS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALGDS | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGDS |
Orthologs
for RALGDS gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for RALGDS gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RALGDS1 |
ral guanine nucleotide dissociation stimulator |
78.4(n)
76.28(a) |
|
427758 XM_425331.3 XP_425331.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RALGDS6 |
-- |
63(a) |
1 ↔ 1 |
GL344285.1(41627-53706) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.288642 |
Xenopus laevis transcribed sequence with moderate similarity more |
76.14(n) |
|
BX843353.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
rab2l2 |
ras-associated protein |
76.19(n) |
|
65227 AF202722.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rgl6 |
Ral guanine nucleotide exchange factor |
25(a) |
1 → many |
3L(13899997-13918435) |
worm
(Caenorhabditis elegans) |
Secernentea |
rgl-16 |
Ral GDS-Like family member (rgl-1) |
23(a) |
1 → many |
X(3210463-3220357) |
ENSEMBL Gene Tree for RALGDS (if available)
TreeFam Gene Tree for RALGDS (if available) |
Paralogs
for RALGDS gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RALGDS gene
- RALGPS22 RAPGEF12 RASGRF12 RGL22 SOS22 RASGRF22 SOS12 RGL32
- RALGPS12 RGL12 RGL42
10 SIMAP similar genes for RALGDS using alignment to 9 protein entries: GNDS_HUMAN (see all proteins):FLJ00371 GBGT1 FLJ00185 DKFZp686C2469 RGL1 HKE1.5
RGL2 RGL4 FLJ00153 RGL3
RALGDS for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for RALGDS
PGOHUM00000238790 PGOHUM00000236345
|
Genomic Variants
for RALGDS gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RALGDS (135973107 - 136039301 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RALGDS: --
Human Gene Mutation Database (HGMD): RALGDS
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RALGDS |
|
Disorders
/ Diseases
for RALGDS gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RALGDS for disorders About GeneDecksing
OMIM gene information: 601619
OMIM disorders: --
13  diseases for RALGDS: About MalaCardsglanzmann's thrombasthenia thrombasthenia tuberous sclerosis embryonal carcinoma
ovarian cancer pancreatic cancer colorectal cancer prostate cancer
pancreatitis prostatitis thyroiditis melanoma
carcinoma
3 Novoseek disease relationships for RALGDS gene About this table
Export disorders for RALGDS gene to outside databases
|
Publications
for RALGDS gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RALGDS gene, integrated from 9 sources (see all 121):
(articles sorted by number of sources associating them with RALGDS) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. (PubMed id 7972015)1, 2, 3 Hofer F.... Martin G.S. (1994)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. (PubMed id 9365783)1, 2 Humphrey D.... Kwiatkowski D.J. (1997)
- Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. (PubMed id 9302994)1, 2 Geyer M.... Kalbitzer H.R. (1997)
- PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. (PubMed id 11889038)1, 9 Tian X....Feig L.A. (2002)
- Structure characterization of human RalGDS gene, and the identification of its novel variant. (PubMed id 11455956)1, 9 Zheng Q....Zhao S. (2000)
- Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS. (PubMed id 9516482)1, 9 Shirouzu M....Yokoyama S. (1998)
- Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. (PubMed id 18417737)1, 9 Rondaij M.G....Voorberg J. (2008)
- Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. (PubMed id 11840339)1, 9 Ramirez de Molina A....Lacal J.C. (2002)
- RalA functions as an indispensable signal mediator for the nutrient-sensing system. (PubMed id 18948269)1, 9 Maehama T....Hanada K. (2008)
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External Searches for RALGDS gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RALGDS gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing RALGDS gene
(According to HUGE)
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Specialized Databases showing RALGDS gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for RALGDS gene:
Search GeneIP for patents involving RALGDS
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RALGDS gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RALGDS | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RALGDS | | | OriGene Protein Over-expression Lysate for RALGDS | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RALGDS | | OriGene 3'-UTR Clone for RALGDS | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGDS | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RALGDS | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RALGDS | | OriGene Custom Protein Services for RALGDS | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RALGDS | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RALGDS | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGDS | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RALGDS | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALGDS | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALGDS |
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| | | | Search Tocris compounds for RALGDS |
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 | | | RALGDS Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGDS |
|  |  |  | | | | Search ThermoFisher Antibodies for RALGDS |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGDS |
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