Aliases for RALGDS Gene
External Ids for RALGDS Gene
Previous GeneCards Identifiers for RALGDS Gene
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
GeneCards Summary for RALGDS Gene
RALGDS (Ral Guanine Nucleotide Dissociation Stimulator) is a Protein Coding gene. Diseases associated with RALGDS include aortic valve insufficiency and afibrinogenemia, congenital. Among its related pathways are Signaling by GPCR and Ras signaling pathway. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and GTPase regulator activity. An important paralog of this gene is RALGPS1.
UniProtKB/Swiss-Prot for RALGDS Gene
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap