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Aliases for RALGDS Gene

Aliases for RALGDS Gene

  • Ral Guanine Nucleotide Dissociation Stimulator 2 3
  • Ral Guanine Nucleotide Exchange Factor 3 4
  • RalGEF 3 4
  • RGF 3 4
  • KIAA1308 4
  • RalGDS 4
  • RGDS 3

External Ids for RALGDS Gene

Previous GeneCards Identifiers for RALGDS Gene

  • GC09U990066
  • GC09M127529
  • GC09M129327
  • GC09M131249
  • GC09M133002
  • GC09M134962
  • GC09M135973
  • GC09M105466

Summaries for RALGDS Gene

Entrez Gene Summary for RALGDS Gene

  • Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]

GeneCards Summary for RALGDS Gene

RALGDS (Ral Guanine Nucleotide Dissociation Stimulator) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS1.

UniProtKB/Swiss-Prot for RALGDS Gene

  • Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

Gene Wiki entry for RALGDS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGDS Gene

Genomics for RALGDS Gene

Regulatory Elements for RALGDS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RALGDS Gene

Start:
133,097,720 bp from pter
End:
133,149,334 bp from pter
Size:
51,615 bases
Orientation:
Minus strand

Genomic View for RALGDS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALGDS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGDS Gene

Proteins for RALGDS Gene

  • Protein details for RALGDS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12967-GNDS_HUMAN
    Recommended name:
    Ral guanine nucleotide dissociation stimulator
    Protein Accession:
    Q12967
    Secondary Accessions:
    • B7Z753
    • E7ER93
    • E7ERZ0
    • Q5T7V4
    • Q6KH11
    • Q6PCE1
    • Q6ZSD5
    • Q9HAX7
    • Q9HAY1
    • Q9HCT1
    • Q9P2N8

    Protein attributes for RALGDS Gene

    Size:
    914 amino acids
    Molecular mass:
    100607 Da
    Quaternary structure:
    • Interacts with RIT1 and RIT2.

    Three dimensional structures from OCA and Proteopedia for RALGDS Gene

    Alternative splice isoforms for RALGDS Gene

neXtProt entry for RALGDS Gene

Proteomics data for RALGDS Gene at MOPED

Post-translational modifications for RALGDS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGDS Gene

No data available for DME Specific Peptides for RALGDS Gene

Domains for RALGDS Gene

Graphical View of Domain Structure for InterPro Entry

Q12967

UniProtKB/Swiss-Prot:

GNDS_HUMAN :
  • Q12967
Domain:
  • The Ras-associating domain interacts with Ras
  • Contains 1 N-terminal Ras-GEF domain.
  • Contains 1 Ras-associating domain.
  • Contains 1 Ras-GEF domain.
genes like me logo Genes that share domains with RALGDS: view

No data available for Gene Families for RALGDS Gene

Function for RALGDS Gene

Molecular function for RALGDS Gene

GENATLAS Biochemistry: Ral guanine nucleotide dissociation stimulator,related protein,115kDa,involved in signal transduction
UniProtKB/Swiss-Prot Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

Gene Ontology (GO) - Molecular Function for RALGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 20936779
GO:0030695 GTPase regulator activity NAS 9365783
genes like me logo Genes that share ontologies with RALGDS: view
genes like me logo Genes that share phenotypes with RALGDS: view

Animal Models for RALGDS Gene

MGI Knock Outs for RALGDS:

Animal Model Products

CRISPR Products

miRNA for RALGDS Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGDS

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RALGDS Gene

Localization for RALGDS Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGDS Gene COMPARTMENTS Subcellular localization image for RALGDS gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RALGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 22797597
GO:0005829 cytosol TAS --
GO:0005903 brush border IDA 22797597
genes like me logo Genes that share ontologies with RALGDS: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RALGDS Gene

Pathways for RALGDS Gene

genes like me logo Genes that share pathways with RALGDS: view

Gene Ontology (GO) - Biological Process for RALGDS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction --
GO:0007265 Ras protein signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with RALGDS: view

Compounds for RALGDS Gene

(1) HMDB Compounds for RALGDS Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(5) Novoseek inferred chemical compound relationships for RALGDS Gene

Compound -log(P) Hits PubMed IDs
gdp 62.5 3
gtp 56.4 5
guanine 53.9 2
phosphatidylinositol 52.8 9
phosphoinositide 13.9 2
genes like me logo Genes that share compounds with RALGDS: view

Transcripts for RALGDS Gene

Unigene Clusters for RALGDS Gene

Ral guanine nucleotide dissociation stimulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGDS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALGDS Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - - - - - - - - - - - - - - - - -
SP7: - -
SP8: -
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -

Relevant External Links for RALGDS Gene

GeneLoc Exon Structure for
RALGDS
ECgene alternative splicing isoforms for
RALGDS

Expression for RALGDS Gene

mRNA expression in normal human tissues for RALGDS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RALGDS Gene

SOURCE GeneReport for Unigene cluster for RALGDS Gene Hs.106185

genes like me logo Genes that share expressions with RALGDS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RALGDS Gene

Orthologs for RALGDS Gene

This gene was present in the common ancestor of chordates.

Orthologs for RALGDS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALGDS 35
  • 97.87 (n)
  • 97.91 (a)
RALGDS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALGDS 35
  • 88.35 (n)
  • 89.47 (a)
RALGDS 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGDS 35
  • 88.26 (n)
  • 89.74 (a)
RALGDS 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralgds 35
  • 85.33 (n)
  • 87.79 (a)
Ralgds 16
Ralgds 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALGDS 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALGDS 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralgds 35
  • 85.34 (n)
  • 87.6 (a)
chicken
(Gallus gallus)
Aves RALGDS 35
  • 78.82 (n)
  • 76.68 (a)
RALGDS 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGDS 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.28864 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgds 35
  • 74.87 (n)
  • 75.26 (a)
zebrafish
(Danio rerio)
Actinopterygii rab2l 35
RALGDS 36
  • 62 (a)
OneToOne
si:ch211-251j10.3 35
  • 65.66 (n)
  • 63.95 (a)
Species with no ortholog for RALGDS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RALGDS Gene

ENSEMBL:
Gene Tree for RALGDS (if available)
TreeFam:
Gene Tree for RALGDS (if available)

Paralogs for RALGDS Gene

Paralogs for RALGDS Gene

Pseudogenes.org Pseudogenes for RALGDS Gene

genes like me logo Genes that share paralogs with RALGDS: view

Variants for RALGDS Gene

Sequence variations from dbSNP and Humsavar for RALGDS Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs472813 -- 133,138,897(-) CAGCA(C/T)TTTGG intron-variant
rs477000 -- 133,131,341(+) AGGGG(A/G)GCCCT intron-variant, upstream-variant-2KB
rs482670 -- 133,131,971(+) TGCCA(A/C)AGGGT intron-variant, upstream-variant-2KB
rs489652 -- 133,135,523(+) GCACC(A/G)CAGCT intron-variant
rs526449 -- 133,137,274(+) TTTCA(C/T)GCCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGDS Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv831744 CNV Gain+Loss 17160897
nsv894030 CNV Loss 21882294
dgv8320n71 CNV Loss 21882294
nsv466610 CNV Loss 19166990
esv1008406 CNV Deletion 20482838
esv1320546 CNV Deletion 17803354
nsv508565 CNV Loss 20534489
esv2739149 CNV Deletion 23290073
esv2672482 CNV Deletion 23128226
nsv894034 CNV Loss 21882294
dgv8321n71 CNV Gain 21882294
nsv894036 CNV Loss 21882294
nsv894037 CNV Gain 21882294
dgv8322n71 CNV Gain 21882294
dgv8323n71 CNV Gain 21882294

Relevant External Links for RALGDS Gene

HapMap Linkage Disequilibrium report
RALGDS
Human Gene Mutation Database (HGMD)
RALGDS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALGDS Gene

Disorders for RALGDS Gene

(3) Novoseek inferred disease relationships for RALGDS Gene

Disease -log(P) Hits PubMed IDs
cancer 1.89 2
metastasis 0 4
tumors 0 2
genes like me logo Genes that share disorders with RALGDS: view

No data available for UniProtKB/Swiss-Prot for RALGDS Gene

Publications for RALGDS Gene

  1. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. (PMID: 7972015) Hofer F. … Martin G.S. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4
  2. Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. (PMID: 9302994) Geyer M. … Kalbitzer H.R. (Nat. Struct. Biol. 1997) 3 4
  3. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. (PMID: 9365783) Humphrey D. … Kwiatkowski D.J. (Ann. Hum. Genet. 1997) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4

Products for RALGDS Gene

Sources for RALGDS Gene

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