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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RALGDS Gene

protein-coding   GIFtS: 63
GCID: GC09M135973

Ral Guanine Nucleotide Dissociation Stimulator

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ral Guanine Nucleotide Dissociation Stimulator1 2     RGDS2
Ral Guanine Nucleotide Exchange Factor2 3     KIAA13083
RGF2 3     RalGDS3
RalGEF2 3     

External Ids:    HGNC: 98421   Entrez Gene: 59002   Ensembl: ENSG000001602717   OMIM: 6016195   UniProtKB: Q129673   

Export aliases for RALGDS gene to outside databases

Previous GC identifers: GC09U990066 GC09M127529 GC09M129327 GC09M131249 GC09M133002 GC09M134962 GC09M105466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RALGDS Gene:
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of
Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.(supplied
by OMIM, Nov 2010)

GeneCards Summary for RALGDS Gene: 
RALGDS (ral guanine nucleotide dissociation stimulator) is a protein-coding gene. Diseases associated with RALGDS include thrombasthenia, and glanzmann's thrombasthenia, and among its related super-pathways are Signalling to RAS and NGF signalling via TRKA from the plasma membrane. GO annotations related to this gene include small GTPase regulator activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is RALGPS2.

UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967
Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding
and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

Gene Wiki entry for RALGDS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_035014.4  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RALGDS gene promoter:
         COUP-TF1   FOXF2   COUP   HNF-4alpha2   STAT5A   HNF-4alpha1   COUP-TF   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RALGDS promoter sequence
   Search SABiosciences Chromatin IP Primers for RALGDS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGDS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.3

RALGDS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGDS gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M135973:  view genomic region     (about GC identifiers)

Start:
135,973,107 bp from pter      End:
136,039,301 bp from pter
Size:
66,195 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967 (See protein sequence)
Recommended Name: Ral guanine nucleotide dissociation stimulator  
Size: 914 amino acids; 100607 Da
Subunit: Interacts with RIT1 and RIT2 (By similarity)
4 PDB 3D structures from and Proteopedia for RALGDS:
1RAX (3D)        2B3A (3D)        2RGF (3D)        3KH0 (3D)    
Secondary accessions: Q5T7V4 Q6KH11 Q9HAX7 Q9HAY1 Q9HCT1 Q9P2N8
Alternative splicing: 3 isoforms:  Q12967-1   Q12967-2   Q12967-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGDS: NX_Q12967

Explore proteomics data for RALGDS at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12967

  • RALGDS Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RALGDS Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001035827.1  NP_001258703.1  NP_001258704.1  NP_001258705.1  NP_006257.1  

    ENSEMBL proteins: 
     ENSP00000361120   ENSP00000361117   ENSP00000376867   ENSP00000391814   ENSP00000437518  
     ENSP00000361132   ENSP00000376864  
    Reactome Protein details: Q12967
    Human Recombinant Protein Products for RALGDS: 
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    Novus Biologicals RALGDS Proteins
    Novus Biologicals RALGDS Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RALGDS 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    RALGDS for ontologies           About GeneDecksing



    RALGDS Antibody Products: 
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    Cloud-Clone Corp. ELISAs for RALGDS 
    Cloud-Clone Corp. CLIAs for RALGDS


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR008937 Ras_GEF
     IPR023578 Ras_GEF_dom
     IPR001895 RasGRF_CDC25
     IPR000159 Ras-assoc
     IPR015758 RalGDS

    Graphical View of Domain Structure for InterPro Entry Q12967

    ProtoNet protein and cluster: Q12967

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000463 Cytosolic fatty-acid binding protein
    IPB001895 Guanine-nucleotide dissociation stimulator CDC25


    UniProtKB/Swiss-Prot: GNDS_HUMAN, Q12967
    Domain: The Ras-associating domain interacts with Ras
    Similarity: Contains 1 N-terminal Ras-GEF domain
    Similarity: Contains 1 Ras-associating domain
    Similarity: Contains 1 Ras-GEF domain


    RALGDS for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GNDS_HUMAN, Q12967
    Function: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding
    and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap

         Genatlas biochemistry entry for RALGDS:
    Ral guanine nucleotide dissociation stimulator,related protein,115kDa,involved in signal transduction

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity NAS9365783
    GO:0005085guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI--
         
    RALGDS for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for RALGDS:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ralgds):
     homeostasis/metabolism  tumorigenesis 

    RALGDS for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ralgdstm1Cjm for RALGDS

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RALGDS 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RALGDS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALGDS 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RALGDS 

    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate RALGDS (see all 30):
    hsa-miR-30c hsa-miR-302d hsa-miR-520e hsa-miR-30d hsa-miR-302e hsa-miR-449a hsa-miR-520a-3p hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidRALGDS 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGDS


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RALGDS About   (see all 21)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signalling to RAS
    Signalling to RAS0.73
    p38MAPK events0.48
    Signalling to ERKs0.73
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    3G-protein signaling K-RAS regulation pathway
    G-protein signaling K-RAS regulation pathway0.96
    4G-protein signaling Rap1A regulation pathway
    G-protein signaling Rap1A regulation pathway0.88
    5G-protein signaling N-RAS regulation pathway
    G-protein signaling N-RAS regulation pathway0.83

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for RALGDS (see all 7)
        G-protein signaling K-RAS regulation pathway
    Cytoskeleton remodeling RalB regulation pathway
    G-protein signaling N-RAS regulation pathway
    Cytoskeleton remodeling RalA regulation pathway
    G-protein signaling Rap1A regulation pathway

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RALGDS
        FGF Pathway
    Molecular Mechanisms of Cancer
    p38 Signaling
    Phospholipase-C Pathway
    Ras Pathway

    5/7 GeneGo (Thomson Reuters) Pathways for RALGDS (see all 7)
        G-protein signaling H-RAS regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Rap1A regulation pathway
    Cytoskeleton remodeling RalB regulation pathway
    G-protein signaling K-RAS regulation pathway

    3 BioSystems Pathways for RALGDS
        EGFR1 Signaling Pathway
    TSH signaling pathway
    ErbB1 downstream signaling

    5/6        Reactome Pathways for RALGDS (see all 6)
        p38MAPK events
    Signal Transduction
    Signalling to RAS
    Signalling by NGF
    Signalling to ERKs


    3         Kegg Pathways  (Kegg details for RALGDS):
        Pathways in cancer
    Colorectal cancer
    Pancreatic cancer


    RALGDS for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RALGDS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for RALGDS (Q129672, 3 ENSP000003611204) via UniProtKB, MINT, STRING, and/or I2D (see all 38)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRASP011123, ENSP000003098454I2D: score=7 STRING: ENSP00000309845
    RAP1AP628343, ENSP000003487864I2D: score=5 STRING: ENSP00000348786
    RIT2Q995783, ENSP000003218054I2D: score=3 STRING: ENSP00000321805
    ARRB1P494073, ENSP000003771414I2D: score=2 STRING: ENSP00000377141
    ARRB2P321213, ENSP000002692604I2D: score=2 STRING: ENSP00000269260
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction ----
    GO:0007264small GTPase mediated signal transduction ----
    GO:0007265Ras protein signal transduction TAS--
    GO:0048011neurotrophin TRK receptor signaling pathway TAS--
    GO:0051056regulation of small GTPase mediated signal transduction IEA--

    RALGDS for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RALGDS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RALGDS (GNDS)

    1 HMDB Compound for RALGDS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for RALGDS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62.5 3 10022812 (2), 8637701 (1)
    gtp 56.4 5 17295314 (1), 8637701 (1), 9230043 (1), 19776012 (1) (see all 5)
    guanine 53.9 2 20118982 (1), 17315921 (1)
    phosphatidylinositol 52.8 13 8643674 (1), 10733581 (1), 20118982 (1), 12829429 (1) (see all 9)
    phosphoinositide 13.9 2 16691442 (1), 10866657 (1)

    Search CenterWatch for drugs/clinical trials and news about RALGDS / GNDS

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RALGDS gene (5 alternative transcripts): 
    NM_001042368.2  NM_001271774.1  NM_001271775.1  NM_001271776.1  NM_006266.3  

    Unigene Cluster for RALGDS:

    Ral guanine nucleotide dissociation stimulator
    Hs.106185  [show with all ESTs]
    Unigene Representative Sequence: AB037729
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000482648 ENST00000469972(uc004ccv.1 uc004ccu.1) ENST00000493438(uc004ccp.3)
    ENST00000372050(uc004cco.3) ENST00000372047(uc004ccn.3 uc004ccq.3 uc011mcv.2)
    ENST00000393160(uc004ccs.3) ENST00000498797 ENST00000495621 ENST00000477660
    ENST00000424572 ENST00000471109 ENST00000493067 ENST00000460587 ENST00000542690(uc011mcw.2)
    ENST00000372062 ENST00000393157(uc004ccr.3)
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    Additional mRNA sequence: 

    AB037729.1 AF027169.1 AF295773.1 AK000242.1 AK024575.1 AK056462.1 AK074114.1 AK090450.1 
    AK127524.1 AK293997.1 AK301470.1 BC021581.1 BC033198.1 BC040737.1 BC059362.1 BC150504.1 
    U14417.1 

    24/26 DOTS entries (see all 26):

    DT.75173495  DT.101961836  DT.100037283  DT.100795494  DT.100802244  DT.100795495  DT.100688537  DT.101959065 
    DT.121187273  DT.101983852  DT.92439161  DT.92439154  DT.95157053  DT.95157064  DT.121187301  DT.121187312 
    DT.95157086  DT.121187315  DT.40222114  DT.433942  DT.92020609  DT.95157052  DT.95157060  DT.95157061 

    24/281 AceView cDNA sequences (see all 281):

    BU175538 AI539258 BM927290 AI810869 NM_006266 BM846544 AI874400 BM741401 
    AI683076 F03268 BM756793 BM919894 BF593805 BX283576 BF739937 BM747976 
    CA311028 BG752913 BG058342 BE328664 AA985516 AI859194 AF295773 AF027169 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for RALGDS (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b · 13c ^
    SP1:                          -                       -                                                                 -     -     -                       -   
    SP2:                          -                                                                                         -     -     -                       -   
    SP3:                          -                       -                                                                 -     -     -                       -   
    SP4:                                                                                                                    -     -     -                       -   
    SP5:                                                                                                                    -     -     -                       -   

    ExUns: 14 ^ 15a · 15b ^ 16a · 16b · 16c ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b
    SP1:        -                                         -           -           -               
    SP2:        -                                         -           -           -               
    SP3:        -                                         -                       -               
    SP4:        -                                         -                                       
    SP5:        -                                                                                 


    ECgene alternative splicing isoforms for RALGDS

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RALGDS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGACGGGG
    RALGDS Expression
    About this image


    See RALGDS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RALGDS

    SOURCE GeneReport for Unigene cluster: Hs.106185
        SABiosciences Custom PCR Arrays for RALGDS
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RALGDS gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgds1 , 5 ral guanine nucleotide dissociation stimulator1, 5 85.59(n)1
    87.91(a)1
      2 (19.38 cM)5
    197301  NM_001145836.11  NP_001139308.11 
     285131255 
    chicken
    (Gallus gallus)
    Aves RALGDS1 ral guanine nucleotide dissociation stimulator 78.4(n)
    76.28(a)
      427758  XM_425331.3  XP_425331.3 
    lizard
    (Anolis carolinensis)
    Reptilia RALGDS6
    --
    --
    63(a)
    40(a)
    1 ↔ 1
    possible ortholog
    GL344285.1(41627-54316)
    GL344486.1(4270-15739)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.288642 Xenopus laevis transcribed sequence with moderate similarity more 76.14(n)    BX843353.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rab2l2 ras-associated protein 76.19(n)   65227  AF202722.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rgl6
    Ral guanine nucleotide exchange factor
    24(a)
    1 → many
    3L(13899997-13918435)
    worm
    (Caenorhabditis elegans)
    Secernentea rgl-16
    Protein RGL-1, isoform a
    25(a)
    1 → many
    X(3210473-3220369)


    ENSEMBL Gene Tree for RALGDS (if available)
    TreeFam Gene Tree for RALGDS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RALGDS gene
    RALGPS22  RAPGEF12  RASGRF12  RGL22  SOS22  RASGRF22  SOS12  RGL32  
    RALGPS12  RGL42  RGL12  
    9 SIMAP similar genes for RALGDS using alignment to 9 protein entries:     GNDS_HUMAN (see all proteins):
    FLJ00371    GBGT1    FLJ00185    DKFZp686C2469    RGL1    HKE1.5
    RGL4    RGL2    FLJ00153

    RALGDS for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RALGDS
    PGOHUM00000238790 PGOHUM00000236345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1350 SNPs in RALGDS are shown (see all 1350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358224
    A colorectal cancer sample4--see VAR_0358222 R L mis40--------
    rs1162847671,2
    C,F--135972612(+) CCTCCC/TGAATA 5 -- int11Minor allele frequency- T:0.08WA 118
    rs1492744711,2
    C--135972637(+) TGCCTA/GGCACC 5 -- int10--------
    rs1435210411,2
    --135972740(+) CCTTGG/TCCTCC 5 -- int10--------
    rs1863446591,2
    --135972778(+) CACCAC/TGCCTG 5 -- int10--------
    rs1153307691,2
    F--135972988(+) TTTTCC/TTGTGC 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1480072741,2
    --135973045(+) ATGTGA/GGAGTC 5 -- int10--------
    rs1918874811,2
    --135973244(+) CACCCA/CACCCC 5 -- ut310--------
    rs1815017641,2
    --135973250(+) ACCCCC/GACCCC 5 -- ut310--------
    rs1172429411,2
    C,F--135973281(+) CCCCCG/ATCTTG 5 -- ut311Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for RALGDS (135973107 - 136039301 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for RALGDS (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1320546CNV Deletion17803354
    esv2739149CNV Deletion23290073
    esv1008406CNV Deletion20482838
    esv2672482CNV Deletion23128226
    esv2739138CNV Deletion23290073
    nsv894036CNV Loss21882294
    nsv466610CNV Loss19166990
    nsv894034CNV Loss21882294
    nsv508565CNV Loss20534489
    dgv8320n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): RALGDS
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601619    OMIM disorders: --

    12 diseases for RALGDS:    About MalaCards
    thrombasthenia    glanzmann's thrombasthenia    tuberous sclerosis    pancreatic cancer
    colorectal cancer    ovarian cancer    pancreatitis    thyroiditis
    melanoma    prostate cancer    endotheliitis    prostatitis


    RALGDS for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for RALGDS gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 1.89 2 15766656 (1), 17568777 (1)
    metastasis 0 4 11486034 (4)
    tumors 0 4 11486034 (1), 15766656 (1)


    Export disorders for RALGDS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RALGDS gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with RALGDS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. (PubMed id 7972015)1, 2, 3 Hofer F.... Martin G.S. (1994)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    3. Cloning and evaluation of RALGDS as a candidate for the tuberous sclerosis gene TSC1. (PubMed id 9365783)1, 2 Humphrey D.... Kwiatkowski D.J. (1997)
    4. Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling. (PubMed id 9302994)1, 2 Geyer M.... Kalbitzer H.R. (1997)
    5. PDK1 mediates growth factor-induced Ral-GEF activation by a kinase-independent mechanism. (PubMed id 11889038)1, 9 Tian X....Feig L.A. (2002)
    6. Structure characterization of human RalGDS gene, and the identification of its novel variant. (PubMed id 11455956)1, 9 Zheng Q....Zhao S. (2000)
    7. Interactions of the amino acid residue at position 31 of the c-Ha-Ras protein with Raf-1 and RalGDS. (PubMed id 9516482)1, 9 Shirouzu M....Yokoyama S. (1998)
    8. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells. (PubMed id 18417737)1, 9 Rondaij M.G....Voorberg J. (2008)
    9. Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. (PubMed id 11840339)1, 9 Ramirez de Molina A....Lacal J.C. (2002)
    10. RalA functions as an indispensable signal mediator for the nutrient-sensing system. (PubMed id 18948269)1, 9 Maehama T....Hanada K. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5900 HGNC: 9842 AceView: RALGDS Ensembl:ENSG00000160271 euGenes: HUgn5900
    ECgene: RALGDS Kegg: 5900 H-InvDB: RALGDS

    (According to HUGE)
    About This Section
    HUGE: KIAA1308

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RALGDS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALGDS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RALGDS gene:
    Search GeneIP for patents involving RALGDS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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