Aliases for RALGDS Gene
External Ids for RALGDS Gene
Previous GeneCards Identifiers for RALGDS Gene
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010]
GeneCards Summary for RALGDS Gene
RALGDS (Ral Guanine Nucleotide Dissociation Stimulator) is a Protein Coding gene. Diseases associated with RALGDS include Aortic Valve Insufficiency. Among its related pathways are G-protein signaling N-RAS regulation pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity and GTPase regulator activity. An important paralog of this gene is RGL1.
UniProtKB/Swiss-Prot for RALGDS Gene
Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.