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Aliases for RALGAPB Gene

Aliases for RALGAPB Gene

  • Ral GTPase Activating Protein Non-Catalytic Beta Subunit 2 3
  • KIAA1219 2 3 4
  • Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic) 3 5
  • RalGAPbeta 3
  • P170 4

External Ids for RALGAPB Gene

Previous HGNC Symbols for RALGAPB Gene

  • KIAA1219

Previous GeneCards Identifiers for RALGAPB Gene

  • GC20P036535
  • GC20P037102
  • GC20P033838

Summaries for RALGAPB Gene

GeneCards Summary for RALGAPB Gene

RALGAPB (Ral GTPase Activating Protein Non-Catalytic Beta Subunit) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Translocation of GLUT4 to the plasma membrane. GO annotations related to this gene include protein heterodimerization activity and GTPase activator activity.

UniProtKB/Swiss-Prot for RALGAPB Gene

  • Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Gene Wiki entry for RALGAPB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPB Gene

Genomics for RALGAPB Gene

Regulatory Elements for RALGAPB Gene

Promoters for RALGAPB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RALGAPB on UCSC Golden Path with GeneCards custom track

Genomic Location for RALGAPB Gene

Chromosome:
20
Start:
38,472,806 bp from pter
End:
38,578,861 bp from pter
Size:
106,056 bases
Orientation:
Plus strand

Genomic View for RALGAPB Gene

Genes around RALGAPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALGAPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALGAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGAPB Gene

Proteins for RALGAPB Gene

  • Protein details for RALGAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X10-RLGPB_HUMAN
    Recommended name:
    Ral GTPase-activating protein subunit beta
    Protein Accession:
    Q86X10
    Secondary Accessions:
    • A2A2E8
    • A2A2E9
    • Q5TG31
    • Q8N3D1
    • Q8WWC0
    • Q9H3X8
    • Q9UJR1
    • Q9ULK1
    • Q9Y3G9

    Protein attributes for RALGAPB Gene

    Size:
    1494 amino acids
    Molecular mass:
    166799 Da
    Quaternary structure:
    • Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).
    SequenceCaution:
    • Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB61346.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGAPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGAPB Gene

Proteomics data for RALGAPB Gene at MOPED

Post-translational modifications for RALGAPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGAPB Gene

No data available for DME Specific Peptides for RALGAPB Gene

Domains & Families for RALGAPB Gene

Protein Domains for RALGAPB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RALGAPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86X10

UniProtKB/Swiss-Prot:

RLGPB_HUMAN :
  • Contains 1 Rap-GAP domain.
Domain:
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with RALGAPB: view

No data available for Gene Families for RALGAPB Gene

Function for RALGAPB Gene

Molecular function for RALGAPB Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
genes like me logo Genes that share phenotypes with RALGAPB: view

Animal Models for RALGAPB Gene

MGI Knock Outs for RALGAPB:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALGAPB Gene

Localization for RALGAPB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGAPB Gene COMPARTMENTS Subcellular localization image for RALGAPB gene
Compartment Confidence
cytosol 3
nucleus 3
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RALGAPB Gene

Pathways & Interactions for RALGAPB Gene

genes like me logo Genes that share pathways with RALGAPB: view

Pathways by source for RALGAPB Gene

1 GeneTex pathway for RALGAPB Gene

Gene Ontology (GO) - Biological Process for RALGAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RALGAPB: view

No data available for SIGNOR curated interactions for RALGAPB Gene

Drugs & Compounds for RALGAPB Gene

(1) Drugs for RALGAPB Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
RBC8 Pharma 0
genes like me logo Genes that share compounds with RALGAPB: view

Transcripts for RALGAPB Gene

Unigene Clusters for RALGAPB Gene

Ral GTPase activating protein, beta subunit (non-catalytic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for RALGAPB Gene

GeneLoc Exon Structure for
RALGAPB
ECgene alternative splicing isoforms for
RALGAPB

Expression for RALGAPB Gene

mRNA expression in normal human tissues for RALGAPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RALGAPB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7), Testis (7.0), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGAPB Gene



SOURCE GeneReport for Unigene cluster for RALGAPB Gene Hs.598850

mRNA Expression by UniProt/SwissProt for RALGAPB Gene

Q86X10-RLGPB_HUMAN
Tissue specificity: Highly expressed in brain, mostly in amygdala.
genes like me logo Genes that share expression patterns with RALGAPB: view

Protein tissue co-expression partners for RALGAPB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RALGAPB Gene

Orthologs for RALGAPB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALGAPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALGAPB 36
  • 100 (a)
OneToOne
RALGAPB 35
  • 99.78 (n)
  • 99.87 (a)
cow
(Bos Taurus)
Mammalia RALGAPB 35
  • 94.69 (n)
  • 97.86 (a)
RALGAPB 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGAPB 36
  • 98 (a)
OneToOne
RALGAPB 35
  • 95.47 (n)
  • 98.46 (a)
mouse
(Mus musculus)
Mammalia Ralgapb 36
  • 97 (a)
OneToOne
Ralgapb 16
Ralgapb 35
  • 92.55 (n)
  • 97.38 (a)
oppossum
(Monodelphis domestica)
Mammalia RALGAPB 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALGAPB 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralgapb 35
  • 92.12 (n)
  • 97.51 (a)
chicken
(Gallus gallus)
Aves RALGAPB 35
  • 81.92 (n)
  • 92.2 (a)
RALGAPB 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGAPB 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16058 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgapb 35
  • 73.76 (n)
  • 84.16 (a)
Str.20424 35
zebrafish
(Danio rerio)
Actinopterygii ralgapb 36
  • 78 (a)
OneToOne
ralgapb 35
  • 69.31 (n)
  • 79.36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007925 35
  • 50.56 (n)
  • 46.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34408 36
  • 36 (a)
OneToOne
CG34408 35
  • 50.64 (n)
  • 46.54 (a)
worm
(Caenorhabditis elegans)
Secernentea D2085.5 35
  • 40.9 (n)
  • 28.48 (a)
C34C6.2 36
  • 19 (a)
OneToMany
D2085.5 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1742 36
  • 45 (a)
OneToOne
Species with no ortholog for RALGAPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALGAPB Gene

ENSEMBL:
Gene Tree for RALGAPB (if available)
TreeFam:
Gene Tree for RALGAPB (if available)

Paralogs for RALGAPB Gene

(1) SIMAP similar genes for RALGAPB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RALGAPB: view

No data available for Paralogs for RALGAPB Gene

Variants for RALGAPB Gene

Sequence variations from dbSNP and Humsavar for RALGAPB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs805538 -- 38,498,708(+) GCCTT(C/T)TGGAG intron-variant
rs805541 -- 38,540,749(+) CTCTT(A/T)GATTT intron-variant
rs1295992 -- 38,568,758(+) GTACA(A/G)TGTCC intron-variant
rs1303566 -- 38,478,582(+) caccc(A/G)gctaa intron-variant
rs1303567 -- 38,477,514(+) AATAC(A/C)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGAPB Gene

Variant ID Type Subtype PubMed ID
dgv1327e1 CNV Complex 17122850
nsv509769 CNV Insertion 20534489
esv2624452 CNV Deletion 19546169
esv2359941 CNV Deletion 18987734
esv2581563 CNV Deletion 19546169
esv2722399 CNV Deletion 23290073
nsv179180 CNV Loss 16902084

Variation tolerance for RALGAPB Gene

Residual Variation Intolerance Score: 3.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALGAPB Gene

HapMap Linkage Disequilibrium report
RALGAPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALGAPB Gene

Disorders for RALGAPB Gene

Relevant External Links for RALGAPB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALGAPB

No disorders were found for RALGAPB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALGAPB Gene

Publications for RALGAPB Gene

  1. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PMID: 19520869) Shirakawa R. … Horiuchi H. (J. Biol. Chem. 2009) 2 3 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A role for Ral GTPase-activating protein subunit I^ in mitotic regulation. (PMID: 24814574) Personnic N. … Bierne H. (FEBS J. 2014) 3
  5. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3

Products for RALGAPB Gene

Sources for RALGAPB Gene

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