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Aliases for RALGAPB Gene

Aliases for RALGAPB Gene

  • Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic) 2 3
  • KIAA1219 2 3 4
  • Ral GTPase-Activating Protein Subunit Beta 3
  • RalGAPbeta 3
  • P170 4

External Ids for RALGAPB Gene

Previous Symbols for RALGAPB Gene

  • KIAA1219

Summaries for RALGAPB Gene

GeneCards Summary for RALGAPB Gene

RALGAPB (Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for RALGAPB Gene

  • Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Gene Wiki entry for RALGAPB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPB Gene

Genomics for RALGAPB Gene

Genomic Location for RALGAPB Gene

Start:
38,472,806 bp from pter
End:
38,578,861 bp from pter
Size:
106,056 bases
Orientation:
Plus strand

Genomic View for RALGAPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALGAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGAPB Gene

No data available for Regulatory Elements for RALGAPB Gene

Proteins for RALGAPB Gene

  • Protein details for RALGAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X10-RLGPB_HUMAN
    Recommended name:
    Ral GTPase-activating protein subunit beta
    Protein Accession:
    Q86X10
    Secondary Accessions:
    • A2A2E8
    • A2A2E9
    • Q5TG31
    • Q8N3D1
    • Q8WWC0
    • Q9H3X8
    • Q9UJR1
    • Q9ULK1
    • Q9Y3G9

    Protein attributes for RALGAPB Gene

    Size:
    1494 amino acids
    Molecular mass:
    166799 Da
    Quaternary structure:
    • Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).
    SequenceCaution:
    • Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB61346.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGAPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGAPB Gene

Proteomics data for RALGAPB Gene at MOPED

Post-translational modifications for RALGAPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGAPB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RALGAPB Gene

Domains for RALGAPB Gene

Protein Domains for RALGAPB Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

RLGPB_HUMAN
Domain:
  • Contains 1 Rap-GAP domain.:
    • Q86X10
genes like me logo Genes that share domains with RALGAPB: view

No data available for Gene Families for RALGAPB Gene

Function for RALGAPB Gene

Molecular function for RALGAPB Gene

UniProtKB/Swiss-Prot Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Gene Ontology (GO) - Molecular Function for RALGAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0005488 binding --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with RALGAPB: view

Phenotypes for RALGAPB Gene

MGI mutant phenotypes for RALGAPB:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with RALGAPB: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RALGAPB Gene

Localization for RALGAPB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGAPB Gene COMPARTMENTS Subcellular localization image for RALGAPB gene
Compartment Confidence
cytosol 2
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RALGAPB Gene

Pathways for RALGAPB Gene

genes like me logo Genes that share pathways with RALGAPB: view

Pathways by source for RALGAPB Gene

Gene Ontology (GO) - Biological Process for RALGAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032484 Ral protein signal transduction IEA --
GO:0032880 regulation of protein localization --
GO:0043547 positive regulation of GTPase activity --
GO:0051056 regulation of small GTPase mediated signal transduction --
GO:0060178 regulation of exocyst localization IEA --
genes like me logo Genes that share ontologies with RALGAPB: view

Transcripts for RALGAPB Gene

Unigene Clusters for RALGAPB Gene

Ral GTPase activating protein, beta subunit (non-catalytic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for RALGAPB Gene

GeneLoc Exon Structure for
RALGAPB
ECgene alternative splicing isoforms for
RALGAPB

Expression for RALGAPB Gene

mRNA expression in normal human tissues for RALGAPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGAPB Gene

SOURCE GeneReport for Unigene cluster for RALGAPB Gene Hs.598850

mRNA Expression by UniProt/SwissProt for RALGAPB Gene

Q86X10-RLGPB_HUMAN
Tissue specificity: Highly expressed in brain, mostly in amygdala
genes like me logo Genes that share expressions with RALGAPB: view

Orthologs for RALGAPB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALGAPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALGAPB 36
  • 99.78 (n)
  • 99.87 (a)
RALGAPB 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALGAPB 36
  • 94.69 (n)
  • 97.86 (a)
RALGAPB 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGAPB 36
  • 95.47 (n)
  • 98.46 (a)
RALGAPB 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralgapb 36
  • 92.55 (n)
  • 97.38 (a)
Ralgapb 16
Ralgapb 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALGAPB 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALGAPB 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralgapb 36
  • 92.12 (n)
  • 97.51 (a)
chicken
(Gallus gallus)
Aves RALGAPB 36
  • 81.92 (n)
  • 92.2 (a)
RALGAPB 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGAPB 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16058 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgapb 36
  • 73.76 (n)
  • 84.16 (a)
Str.20424 36
zebrafish
(Danio rerio)
Actinopterygii ralgapb 36
  • 69.31 (n)
  • 79.36 (a)
ralgapb 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007925 36
  • 50.56 (n)
  • 46.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34408 36
  • 50.64 (n)
  • 46.54 (a)
CG34408 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C34C6.2 37
  • 19 (a)
OneToMany
D2085.5 36
  • 40.9 (n)
  • 28.48 (a)
D2085.5 37
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1742 37
  • 45 (a)
OneToOne
Species with no ortholog for RALGAPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALGAPB Gene

ENSEMBL:
Gene Tree for RALGAPB (if available)
TreeFam:
Gene Tree for RALGAPB (if available)

Paralogs for RALGAPB Gene

Selected SIMAP similar genes for RALGAPB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RALGAPB: view

No data available for Paralogs for RALGAPB Gene

Variants for RALGAPB Gene

Sequence variations from dbSNP and Humsavar for RALGAPB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs10557 -- 38,578,033(+) GTTTT(G/T)TGGTA utr-variant-3-prime
rs11636 -- 38,578,775(-) ATCGG(A/C)ATAAA utr-variant-3-prime
rs12986 -- 38,575,296(+) CATTG(A/G)TAGTA utr-variant-3-prime
rs805535 -- 38,487,921(+) attag(C/T)cgggc intron-variant
rs805536 -- 38,489,837(-) GTCCT(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGAPB Gene

Variant ID Type Subtype PubMed ID
dgv1327e1 CNV Complex 17122850
nsv509769 CNV Insertion 20534489
esv2624452 CNV Deletion 19546169
esv2359941 CNV Deletion 18987734
esv2581563 CNV Deletion 19546169
esv2722399 CNV Deletion 23290073
nsv179180 CNV Loss 16902084

Relevant External Links for RALGAPB Gene

HapMap Linkage Disequilibrium report
RALGAPB

Disorders for RALGAPB Gene

No disorders were found for RALGAPB Gene.

No data available for UniProtKB/Swiss-Prot for RALGAPB Gene

Publications for RALGAPB Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RALGAPB Gene

Sources for RALGAPB Gene

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