Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RALGAPB Gene

protein-coding   GIFtS: 48
GCID: GC20P037102

Ral GTPase activating protein, beta subunit (non-catalytic)

(Previous name: KIAA1219 )
(Previous symbol: KIAA1219)
 Explore 1 disease affiliated with
RALGAPB via our new
 Human Malady Compendium 
Biological research products
for RALGAPB
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)1 2     DKFZp781M24111
KIAA12191 2 3     DJ1100H13.11
RalGAPbeta1 2     Ral GTPase-Activating Protein Beta Subunit2
P1701     Ral GTPase-Activating Protein Subunit Beta2

External Ids:    HGNC: 292211   Entrez Gene: 571482   Ensembl: ENSG000001704717   UniProtKB: Q86X103   

Export aliases for RALGAPB gene to outside databases

Previous GC identifers: GC20P036535 GC20P033838


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10
Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for
the Ras-like small GTPases RALA and RALB (By similarity)

Gene Wiki entry for RALGAPB (KIAA1219)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RALGAPB
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for RALGAPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGAPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11.23

RALGAPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGAPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037102:  view genomic region     (about GC identifiers)

Start:
37,101,459 bp from pter      End:
37,207,504 bp from pter
Size:
106,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10 (See protein sequence)
Recommended Name: Ral GTPase-activating protein subunit beta  
Size: 1494 amino acids; 166799 Da
Subunit: Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with
RALGAPA2. Heterodimerization is required for activity (By similarity)
Sequence caution: Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB61346.1;
Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD39096.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
Secondary accessions: A2A2E8 Q5TG31 Q8N3D1 Q8WWC0 Q9H3X8 Q9UJR1 Q9ULK1 Q9Y3G9
Alternative splicing: 4 isoforms:  Q86X10-1   Q86X10-2   Q86X10-3   Q86X10-4   (Splicing acceptor site is not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGAPB: NX_Q86X10

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86X10

  • RALGAPB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065069.1  
    ENSEMBL proteins: 
     ENSP00000262879   ENSP00000380235   ENSP00000380233   ENSP00000416646   ENSP00000442959  
     ENSP00000380231  
    Reactome Protein details: Q86X10
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for RALGAPB 
    GenScript Custom Purified and Recombinant Proteins Services for RALGAPB
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--


    RALGAPB for ontologies           About GeneDecksing



    RALGAPB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for RALGAPB 
    GenScript Custom Superior Antibodies Services for RALGAPB
    Novus Biologicals RALGAPB Antibody
    Search for Antibodies for RALGAPB at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for RALGAPB

    Assay Products for RALGAPB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RALGAPB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RALGAPB for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000331 Rap_GAP_dom

    Graphical View of Domain Structure for InterPro Entry Q86X10

    ProtoNet protein and cluster: Q86X10

    1 Blocks protein family: IPB000331 Rap/ran-GAP

    UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10
    Similarity: Contains 1 Rap-GAP domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10
    Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for
    the Ras-like small GTPases RALA and RALB (By similarity)

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: RALGAPB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RALGAPB
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate RALGAPB (see all 97):
    hsa-miR-26a-2* hsa-miR-642a hsa-miR-485-3p hsa-miR-1245 hsa-miR-30d hsa-miR-219-5p hsa-miR-30a hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RALGAPB (see all 4)
    OriGene shRNA RFP: RALGAPB
    OriGene siRNA: RALGAPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RALGAPB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RALGAPB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RALGAPB (NM_020336)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALGAPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RALGAPB
    Search LifeMap BioReagents cell lines for RALGAPB

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0017123Ral GTPase activator activity ISS--
    GO:0046982protein heterodimerization activity ISS--


    RALGAPB for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ralgapb):
     mortality/aging 

    RALGAPB for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Membrane Trafficking
    Membrane Trafficking1.00
    Translocation of GLUT4 to the Plasma Membrane0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2        Reactome Pathways for RALGAPB
        Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane



    RALGAPB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RALGAPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for RALGAPB (Q86X103 ENSP000002628794) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RALGAPA2Q2PPJ73, ENSP000002026774I2D: score=1 STRING: ENSP00000202677
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    ITSN2Q9NZM33I2D: score=1 
    AKT2ENSP000003758924STRING: ENSP00000375892
    RALAENSP000000052574STRING: ENSP00000005257
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032484Ral protein signal transduction IEA--
    GO:0032859activation of Ral GTPase activity ISS--
    GO:0051056regulation of small GTPase mediated signal transduction ----
    GO:0060178regulation of exocyst localization IEA--


    RALGAPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RALGAPB
    Search CenterWatch for drugs/clinical trials and news about RALGAPB / RLGPB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RALGAPB gene: 
    NM_020336.2  

    Unigene Cluster for RALGAPB:

    Ral GTPase activating protein, beta subunit (non-catalytic)
    Hs.598850  [show with all ESTs]
    Unigene Representative Sequence: NM_020336
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000262879 ENST00000397042 ENST00000397040(uc002xiy.1) ENST00000495949
    ENST00000438490 ENST00000461423(uc002xja.1) ENST00000461147 ENST00000490114
    ENST00000537204 ENST00000397038(uc010zvz.1 uc002xiw.3 uc002xix.3 uc002xiz.3)


    miRNA
    Products:
         
    OriGene 3'-UTR Clone: RALGAPB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RALGAPB
    8/97 QIAGEN miScript miRNA Assays for microRNAs that regulate RALGAPB (see all 97):
    hsa-miR-26a-2* hsa-miR-642a hsa-miR-485-3p hsa-miR-1245 hsa-miR-30d hsa-miR-219-5p hsa-miR-30a hsa-miR-629*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RALGAPB (see all 4)
    OriGene shRNA RFP: RALGAPB
    OriGene siRNA: RALGAPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RALGAPB
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RALGAPB (NM_020336)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALGAPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RALGAPB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RALGAPB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALGAPB

    Additional cDNA sequence: 

    AB621815.1 AK026771.1 AK123576.1 AK125260.1 AK125916.1 AK304242.1 AL132998.1 AL834436.1 
    BC010916.1 BC018668.1 BC036425.2 BC047482.1 BX641080.1 CR936800.1 

    17 DOTS entries:

    DT.92435970  DT.91963351  DT.453174  DT.97784304  DT.91984412  DT.100724159  DT.40280902  DT.99991846 
    DT.100703905  DT.120814111  DT.120814140  DT.40123374  DT.92435969  DT.95275801  DT.120814108  DT.92435967 
    DT.99963796 

    24/292 AceView cDNA sequences (see all 292):

    AA412128 BE502938 AA872554 BU195187 AW241687 AI366165 AA418686 BM681127 
    BQ005996 AA693388 AA424825 CD724041 AA669533 BQ879495 AA774228 R83357 
    BM969530 R68642 CB045923 BQ694897 N81055 BE045889 AI221344 AK123576 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPB    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
    SP1:                                                                                                              -                             -               
    SP2:                                                                                                                                            -               
    SP3:                                                                                                                                            -               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
    SP1:                                -                                 
    SP2:                                -                                 
    SP3:                                -                                 
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for RALGAPB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RALGAPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTTTTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RALGAPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RALGAPB

    SOURCE GeneReport for Unigene cluster: Hs.598850

    UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10
    Tissue specificity: Highly expressed in brain, mostly in amygdala

        SABiosciences Custom PCR Arrays for RALGAPB
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RALGAPB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RALGAPB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALGAPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RALGAPB gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgapb1 , 5 Ral GTPase activating protein, beta subunit (non-catalytic)1, 5 92.55(n)1
    97.38(a)1
      2 (78.72 cM)5
    2288501  NM_177658.31  NP_808326.21 
     1584098485 
    chicken
    (Gallus gallus)
    Aves RALGAPB1 Ral GTPase activating protein, beta subunit (non-catalytic) 81.92(n)
    92.2(a)
      419128  NM_001030846.1  NP_001026017.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALGAPB6
    --
    88(a)
    1 ↔ 1
    4(134780928-134839524)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.160582 Xenopus laevis transcribed sequence with weak similarity more 75.75(n)    BJ071291.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ralgapb1 Ral GTPase activating protein, beta subunit (non-catalytic) 69.33(n)
    79.36(a)
      559303  XM_002662565.2  XP_002662611.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344081 CG34408 50.97(n)
    46.94(a)
      31953  NM_132385.2  NP_572613.2 
    worm
    (Caenorhabditis elegans)
    Secernentea D2085.51 Protein D2085.5 40.53(n)
    28.3(a)
      3564922  NM_001026884.1  NP_001022055.1 


    ENSEMBL Gene Tree for RALGAPB (if available)
    TreeFam Gene Tree for RALGAPB (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RALGAPB gene
    RALGAPA22  TSC22  RALGAPA12  
    1 SIMAP similar gene for RALGAPB using alignment to 5 protein entries:     RLGPB_HUMAN (see all proteins):
    DKFZp686N19168

    RALGAPB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1745 NCBI SNPs in RALGAPB are shown (see all 1745    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347594801,2
    C--33875636(+) CACAT-/ACACACA 1 -- int11Minor allele frequency- AC:0.50NA 2
    rs60998241,2
    C,F,A,H,--37099824(+) GCTTTG/TGGACA 1 -- us2k113Minor allele frequency- T:0.19NS NA CSA WA 1274
    rs1409614261,2
    --37100026(+) AGTACA/TGGGTT 1 -- us2k10--------
    rs60998281,2
    C,F,A,H,--37100072(+) CTCCTG/TTCTTT 1 -- us2k17Minor allele frequency- T:0.12NS EA CSA WA 538
    rs75092301,2
    H--37100097(+) TCAGCA/GCAGCC 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs1130037241,2
    --37100145(+) TACCCT/AGTTCC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1113610161,2
    C,--37100188(+) AACTTC/TTCCAA 1 -- us2k12Minor allele frequency- T:0.03CSA WA 120
    rs16099941,2
    C,F,A,H,--37100214(+) AAGGTC/TTCCTT 1 -- us2k1 tfbs320Minor allele frequency- T:0.11NS EA NA 2332
    rs1385648181,2
    --37100315(+) TCAGCC/TCCTGT 1 -- us2k10--------
    rs60258911,2
    F,--37100372(+) AACTAC/AATAAT 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for RALGAPB (37101459 - 37207504 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for RALGAPB
         2 CNVs: 3217 4101
         3 Indels: 12181 46096 102966

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RALGAPB
    DNA2.0 Custom Variant and Variant Library Synthesis for RALGAPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RALGAPB for disorders           About GeneDecksing

    1 disease for RALGAPB:    About MalaCards
    tuberous sclerosis


    Export disorders for RALGAPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RALGAPB gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with RALGAPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PubMed id 19520869)1, 3 Shirakawa R.... Horiuchi H. (2009)
    2. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PubMed id 16490346)1, 2 Gridley S....Lienhard G.E. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (1999)
    8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57148 HGNC: 29221 AceView: KIAA1219 Ensembl:ENSG00000170471 euGenes: HUgn57148
    ECgene: RALGAPB H-InvDB: RALGAPB

    (According to HUGE)
    About This Section
    HUGE: KIAA1219

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RALGAPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RALGAPB gene:
    Search GeneIP for patents involving RALGAPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for RALGAPB  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RALGAPB   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RALGAPB  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for RALGAPB   OriGene 3'-UTR Clone for RALGAPB  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RALGAPB  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RALGAPB   OriGene Custom Protein Services for RALGAPB  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RALGAPB
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RALGAPB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALGAPB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RALGAPB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALGAPB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
     GenScript Custom Purified and Recombinant Proteins Services for RALGAPB GenScript cDNA clones with any tag delivered in your preferred vector for RALGAPB
     GenScript Custom Assay Services for RALGAPB GenScript Custom Superior Antibodies Services for RALGAPB
     GenScript Custom overexpressing Cell Line Services for RALGAPB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for RALGAPB
     Search Chromatin IP Primers for RALGAPB
     RT2 qPCR Primer Assay in human, mouse, rat RALGAPB
     Search GNC Networks for RALGAPB
     SABiosciences Custom PCR Arrays for RALGAPB
     Search Tocris compounds for RALGAPB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     RALGAPB antibodies
     Search for Antibodies for RALGAPB at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for RALGAPB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for RALGAPB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB
     Browse SwitchGear 3'UTR luciferase reporter plasmids for RALGAPB
     Browse SwitchGear Promoter luciferase reporter plasmids for RALGAPB
     Search ThermoFisher Antibodies for RALGAPB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RALGAPB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4