Aliases for RALGAPB Gene
Aliases for RALGAPB Gene
External Ids for RALGAPB Gene
- HGNC: 29221
- Entrez Gene: 57148
- Ensembl: ENSG00000170471
- UniProtKB: Q86X10
Previous HGNC Symbols for RALGAPB Gene
- KIAA1219
Previous GeneCards Identifiers for RALGAPB Gene
- GC20P036535
- GC20P037102
- GC20P033838
Summaries for RALGAPB Gene
GeneCards Summary for RALGAPB Gene
RALGAPB (Ral GTPase Activating Protein Non-Catalytic Beta Subunit) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and Vesicle-mediated transport. GO annotations related to this gene include protein heterodimerization activity and GTPase activator activity.
UniProtKB/Swiss-Prot for RALGAPB Gene
-
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPB Gene
Genomics for RALGAPB Gene
Regulatory Elements for RALGAPB Gene
Enhancers for RALGAPB Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around RALGAPB on UCSC Golden Path with GeneCards custom track
Promoters for RALGAPB Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around RALGAPB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for RALGAPB Gene
- Chromosome:
- 20
- Start:
- 38,472,806 bp from pter
- End:
- 38,578,861 bp from pter
- Size:
- 106,056 bases
- Orientation:
- Plus strand
Genomic View for RALGAPB Gene
Genes around RALGAPB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by Ensembl
- 20q11.23 by Entrez Gene
- 20q11.23 by HGNC
RALGAPB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RALGAPB Gene
Proteins for RALGAPB Gene
-
Protein details for RALGAPB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86X10-RLGPB_HUMAN
- Recommended name:
- Ral GTPase-activating protein subunit beta
- Protein Accession:
- Q86X10
- A2A2E8
- A2A2E9
- Q5TG31
- Q8N3D1
- Q8WWC0
- Q9H3X8
- Q9UJR1
- Q9ULK1
- Q9Y3G9
Protein attributes for RALGAPB Gene
- Size:
- 1494 amino acids
- Molecular mass:
- 166799 Da
- Quaternary structure:
-
- Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).
- SequenceCaution:
-
- Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB61346.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RALGAPB Gene
Post-translational modifications for RALGAPB Gene
Other Protein References for RALGAPB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RALGAPB
- Novus Biologicals Antibodies for RALGAPB
- GeneTex Arg1 antibody for RALGAPB
-
Santa Cruz Biotechnology (SCBT) Antibodies for RALGAPB
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RALGAPB
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- Novus Biologicals proteins for RALGAPB
- Search GeneTex for Proteins for RALGAPB
Assay Products
No data available for DME Specific Peptides for RALGAPB Gene
Domains & Families for RALGAPB Gene
Protein Domains for RALGAPB Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RALGAPB Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86X10- Domain:
-
- Contains 1 Rap-GAP domain.
No data available for Gene Families for RALGAPB Gene
Function for RALGAPB Gene
Molecular function for RALGAPB Gene
- UniProtKB/Swiss-Prot Function:
- Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.
Phenotypes for RALGAPB Gene
- MGI mutant phenotypes for RALGAPB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RALGAPB:
Animal Models for RALGAPB Gene
- MGI Knock Outs for RALGAPB:
-
- Ralgapb tm1a(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for RALGAPB gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RALGAPB gene
- Search ViGene Biosciences for RALGAPB
CRISPR Products
-
OriGene CRISPR knockouts for RALGAPB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALGAPB
- GenScript: Design CRISPR guide RNA sequences for RALGAPB
miRNA for RALGAPB Gene
- miRTarBase miRNAs that target RALGAPB
-
- hsa-let-7d-5p (MIRT032129)
- hsa-mir-421 (MIRT039454)
- hsa-mir-615-3p (MIRT040158)
- hsa-mir-342-3p (MIRT043719)
- hsa-mir-328-3p (MIRT043758)
- hsa-let-7b-5p (MIRT052119)
- hsa-mir-381-5p (MIRT083459)
- hsa-mir-503-5p (MIRT083460)
- hsa-mir-562 (MIRT083461)
- hsa-mir-548n (MIRT083462)
- hsa-mir-4524a-5p (MIRT083463)
- hsa-mir-4524b-5p (MIRT083465)
- hsa-mir-3158-5p (MIRT118495)
- hsa-mir-298 (MIRT543792)
- hsa-mir-6752-3p (MIRT543793)
- hsa-mir-646 (MIRT543794)
- hsa-mir-6838-5p (MIRT543795)
- hsa-mir-497-5p (MIRT543796)
- hsa-mir-424-5p (MIRT543797)
- hsa-mir-195-5p (MIRT543798)
- hsa-mir-16-5p (MIRT543799)
- hsa-mir-15b-5p (MIRT543800)
- hsa-mir-15a-5p (MIRT543801)
- hsa-mir-6867-5p (MIRT607643)
- hsa-mir-6797-3p (MIRT607644)
- hsa-mir-6076 (MIRT607645)
- hsa-mir-574-5p (MIRT607646)
- hsa-mir-496 (MIRT607647)
- hsa-mir-4540 (MIRT625533)
- hsa-mir-6723-5p (MIRT625534)
- hsa-mir-4711-3p (MIRT625535)
- hsa-mir-29a-5p (MIRT625536)
- hsa-mir-3920 (MIRT625537)
- hsa-mir-607 (MIRT635183)
- hsa-mir-6838-3p (MIRT635184)
miRNA Products
- Search ViGene Biosciences for RALGAPB
Inhibitory RNA Products
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-
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Clone Products
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Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RALGAPB gene
-
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-
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Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-14297) for RALGAPB
No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALGAPB Gene
Localization for RALGAPB Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| nucleus | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| plasma membrane | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RALGAPB Gene
Pathways & Interactions for RALGAPB Gene
More details on SuperPathways for RALGAPB| Superpath | Contained pathways | ||
|---|---|---|---|
| 1 | Vesicle-mediated transport | ||
| 2 | Translocation of GLUT4 to the plasma membrane |
Pathways by source for RALGAPB Gene
1 GeneTex pathway for RALGAPB Gene
3 Reactome pathways for RALGAPB Gene
Interacting Proteins for RALGAPB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0043547 | positive regulation of GTPase activity | IEA | -- |
No data available for SIGNOR curated interactions for RALGAPB Gene
Drugs & Compounds for RALGAPB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| RBC8 | Pharma | 0 |
(1) ApexBio Compounds for RALGAPB Gene
| Compound | Action | Cas Number |
|---|---|---|
| RBC8 | 361185-42-4 |
Drug Products
- ApexBio compounds for RALGAPB
Transcripts for RALGAPB Gene
mRNA/cDNA for RALGAPB Gene
- (8) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (292) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RALGAPB Gene
CRISPR Products
-
OriGene CRISPR knockouts for RALGAPB
-
Santa Cruz Biotechnology (SCBT) CRISPR for RALGAPB
- GenScript: Design CRISPR guide RNA sequences for RALGAPB
miRNA Products
- Search ViGene Biosciences for RALGAPB
Inhibitory RNA Products
- Origene siRNA, shRNA, mouse_rna, and RNAi products in human, mouse, rat for RALGAPB
- Browse OriGene Inhibitory RNA Products For RALGAPB
-
ViGene Biosciences ready-to-package AAV shRNAs for RALGAPB gene
Clone Products
- OriGene clones in human for RALGAPB
- OriGene ORF clones in human,mouse,rat for RALGAPB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-14297) for RALGAPB
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: |
| ExUns: | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29 | ^ | 30a | · | 30b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||
| SP4: | |||||||||||||||||||||
| SP5: |
Expression for RALGAPB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (10.7), Testis (7.0), and Frontal cortex (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGAPB Gene
SOURCE GeneReport for Unigene cluster for RALGAPB Gene Hs.598850
mRNA Expression by UniProt/SwissProt for RALGAPB Gene
Q86X10-RLGPB_HUMAN
Tissue specificity:
Highly expressed in brain, mostly in amygdala.
- Elite partner
Primer Products
-
OriGene qPCR primer pairs for RALGAPB
-
OriGene qPCR primer pairs and template standards for RALGAPB
No data available for mRNA differential expression in normal tissues for RALGAPB Gene
Orthologs for RALGAPB Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | RALGAPB 35 |
|
||
| RALGAPB 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | RALGAPB 35 |
|
||
| RALGAPB 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Ralgapb 35 |
|
||
| Ralgapb 16 |
|
||||
| Ralgapb 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | RALGAPB 35 |
|
||
| RALGAPB 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Ralgapb 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RALGAPB 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RALGAPB 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RALGAPB 35 |
|
||
| RALGAPB 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | RALGAPB 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ralgapb 35 |
|
||
| Str.20424 35 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16058 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ralgapb 35 |
|
||
| ralgapb 36 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007925 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG34408 35 |
|
||
| CG34408 36 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | D2085.5 35 |
|
||
| C34C6.2 36 |
|
OneToMany | |||
| D2085.5 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.1742 36 |
|
OneToOne |
- Species with no ortholog for RALGAPB:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RALGAPB Gene
(1) SIMAP similar genes for RALGAPB Gene using alignment to 5 proteins:
No data available for Paralogs for RALGAPB Gene
Variants for RALGAPB Gene
| SNP ID | Clin | Chr 20 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs10557 | -- | 38,578,033(+) | GTTTT(G/T)TGGTA | utr-variant-3-prime | |
| rs11636 | -- | 38,578,775(-) | ATCGG(A/C)ATAAA | utr-variant-3-prime | |
| rs12986 | -- | 38,575,296(+) | CATTG(A/G)TAGTA | utr-variant-3-prime | |
| rs990827 | -- | 38,575,170(-) | GGAGT(A/G)TGATT | utr-variant-3-prime | |
| rs991539 | -- | 38,571,954(-) | cacca(A/G)tcatc | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1327e1 | CNV | Complex | 17122850 |
| nsv509769 | CNV | Insertion | 20534489 |
| esv2624452 | CNV | Deletion | 19546169 |
| esv2359941 | CNV | Deletion | 18987734 |
| esv2581563 | CNV | Deletion | 19546169 |
| esv2722399 | CNV | Deletion | 23290073 |
| nsv179180 | CNV | Loss | 16902084 |
Residual Variation Intolerance Score:
3.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.12;
51.25% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RALGAPB Gene
Disorders for RALGAPB Gene
Relevant External Links for RALGAPB
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- RALGAPB
No disorders were found for RALGAPB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALGAPB Gene
Publications for RALGAPB Gene
- Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PMID: 19520869) Shirakawa R. … Horiuchi H. (J. Biol. Chem. 2009) 2 3 67
- Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
- A role for Ral GTPase-activating protein subunit I^ in mitotic regulation. (PMID: 24814574) Personnic N. … Bierne H. (FEBS J. 2014) 3
- Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PMID: 24255178) Couzens A.L. … Gingras A.C. (Sci Signal 2013) 3
Products for RALGAPB Gene
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- OriGene qPCR primer pairs for RALGAPB
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- ViGene Biosciences adenoviral particle packaged cDNA for RALGAPB gene
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- ViGene Biosciences lentiviral particle packaged cDNA for RALGAPB gene
- ViGene Biosciences ready-to-package AAV shRNAs for RALGAPB gene
- ViGene Biosciences ready-to-package AAV shRNAs for RALGAPB gene
- ViGene Biosciences ready-to-package AAV shRNAs for RALGAPB gene
- Search ViGene Biosciences for RALGAPB
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- Santa Cruz Biotechnology (SCBT) Antibodies for RALGAPB
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Sources for RALGAPB Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
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