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Aliases for RALGAPB Gene

Aliases for RALGAPB Gene

  • Ral GTPase Activating Protein Non-Catalytic Beta Subunit 2 3 5
  • KIAA1219 2 3 4
  • Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic) 3
  • Ral GTPase-Activating Protein Subunit Beta 3
  • RalGAPbeta 3
  • P170 4

External Ids for RALGAPB Gene

Previous HGNC Symbols for RALGAPB Gene

  • KIAA1219

Previous GeneCards Identifiers for RALGAPB Gene

  • GC20P036535
  • GC20P037102
  • GC20P033838

Summaries for RALGAPB Gene

GeneCards Summary for RALGAPB Gene

RALGAPB (Ral GTPase Activating Protein Non-Catalytic Beta Subunit) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Translocation of GLUT4 to the plasma membrane. GO annotations related to this gene include protein heterodimerization activity and GTPase activator activity.

UniProtKB/Swiss-Prot for RALGAPB Gene

  • Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Gene Wiki entry for RALGAPB Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPB Gene

Genomics for RALGAPB Gene

Regulatory Elements for RALGAPB Gene

Enhancers for RALGAPB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G038803 1.9 FANTOM5 Ensembl ENCODE dbSUPER 3.2 +333.8 333788 6.3 HDGF PKNOX1 ATF1 WRNIP1 FEZF1 TCF12 GLIS2 GATA2 ZNF143 ZNF207 PPP1R16B ACTR5 ARHGAP40 RALGAPB DHX35 RN7SL116P
GH20G038091 2 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -379.0 -379012 5.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 DMAP1 ZNF766 ZNF207 FOS VSTM2L RPRD1B BPI RALGAPB CTNNBL1 RN7SL237P GC20P038089
GH20G038860 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.3 +390.0 389988 4.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B TCF12 GATA2 ZNF143 REST MIER2 PPP1R16B ACTR5 DHX35 RALGAPB RN7SL116P
GH20G038870 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 +401.0 401010 7.2 HDGF PKNOX1 FOXA2 WRNIP1 FEZF1 TCF12 GATA2 ZNF143 ZNF207 PAF1 PPP1R16B FAM83D ACTR5 SLC32A1 DHX35 RALGAPB RN7SL116P GC20M038907
GH20G037985 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -483.1 -483075 8.1 HDGF PKNOX1 FOXA2 WRNIP1 ARID4B YY1 TCF12 GATA2 FOS JUNB TGM2 VSTM2L RPRD1B TTI1 RALGAPB NNAT RN7SKP185 GC20M037976 GC20M037959
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RALGAPB on UCSC Golden Path with GeneCards custom track

Promoters for RALGAPB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000137005 -6 1601 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF263

Genomic Location for RALGAPB Gene

Chromosome:
20
Start:
38,472,806 bp from pter
End:
38,578,861 bp from pter
Size:
106,056 bases
Orientation:
Plus strand

Genomic View for RALGAPB Gene

Genes around RALGAPB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALGAPB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALGAPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGAPB Gene

Proteins for RALGAPB Gene

  • Protein details for RALGAPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X10-RLGPB_HUMAN
    Recommended name:
    Ral GTPase-activating protein subunit beta
    Protein Accession:
    Q86X10
    Secondary Accessions:
    • A2A2E8
    • A2A2E9
    • Q5TG31
    • Q8N3D1
    • Q8WWC0
    • Q9H3X8
    • Q9UJR1
    • Q9ULK1
    • Q9Y3G9

    Protein attributes for RALGAPB Gene

    Size:
    1494 amino acids
    Molecular mass:
    166799 Da
    Quaternary structure:
    • Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex with RALGAPA2. Heterodimerization is required for activity (By similarity).
    SequenceCaution:
    • Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB61346.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD39096.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGAPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGAPB Gene

Post-translational modifications for RALGAPB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RALGAPB Gene

Domains & Families for RALGAPB Gene

Protein Domains for RALGAPB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RALGAPB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RALGAPB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RALGAPB Gene

Function for RALGAPB Gene

Molecular function for RALGAPB Gene

UniProtKB/Swiss-Prot Function:
Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB.

Gene Ontology (GO) - Molecular Function for RALGAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with RALGAPB: view
genes like me logo Genes that share phenotypes with RALGAPB: view

Animal Models for RALGAPB Gene

MGI Knock Outs for RALGAPB:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALGAPB Gene

Localization for RALGAPB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALGAPB gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RALGAPB Gene

Pathways & Interactions for RALGAPB Gene

genes like me logo Genes that share pathways with RALGAPB: view

Pathways by source for RALGAPB Gene

1 GeneTex pathway for RALGAPB Gene

Gene Ontology (GO) - Biological Process for RALGAPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction IEA --
GO:0090630 activation of GTPase activity IBA,ISS --
genes like me logo Genes that share ontologies with RALGAPB: view

No data available for SIGNOR curated interactions for RALGAPB Gene

Drugs & Compounds for RALGAPB Gene

(1) Drugs for RALGAPB Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
RBC8 Pharma 0

(1) ApexBio Compounds for RALGAPB Gene

Compound Action Cas Number
RBC8 361185-42-4
genes like me logo Genes that share compounds with RALGAPB: view

Transcripts for RALGAPB Gene

Unigene Clusters for RALGAPB Gene

Ral GTPase activating protein, beta subunit (non-catalytic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

ExUns: 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for RALGAPB Gene

GeneLoc Exon Structure for
RALGAPB
ECgene alternative splicing isoforms for
RALGAPB

Expression for RALGAPB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RALGAPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RALGAPB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.7), Testis (7.0), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RALGAPB Gene



Protein tissue co-expression partners for RALGAPB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RALGAPB Gene:

RALGAPB

SOURCE GeneReport for Unigene cluster for RALGAPB Gene:

Hs.598850

mRNA Expression by UniProt/SwissProt for RALGAPB Gene:

Q86X10-RLGPB_HUMAN
Tissue specificity: Highly expressed in brain, mostly in amygdala.

Evidence on tissue expression from TISSUES for RALGAPB Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with RALGAPB: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALGAPB Gene

Orthologs for RALGAPB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALGAPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALGAPB 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia RALGAPB 34 35
  • 95.47 (n)
cow
(Bos Taurus)
Mammalia RALGAPB 34 35
  • 94.69 (n)
mouse
(Mus musculus)
Mammalia Ralgapb 34 16 35
  • 92.55 (n)
rat
(Rattus norvegicus)
Mammalia Ralgapb 34
  • 92.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RALGAPB 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALGAPB 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves RALGAPB 34 35
  • 81.92 (n)
lizard
(Anolis carolinensis)
Reptilia RALGAPB 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgapb 34
  • 73.76 (n)
Str.20424 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16058 34
zebrafish
(Danio rerio)
Actinopterygii ralgapb 34 35
  • 69.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34408 34 35
  • 50.64 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007925 34
  • 50.56 (n)
worm
(Caenorhabditis elegans)
Secernentea D2085.5 34 35
  • 40.9 (n)
C34C6.2 35
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1742 35
  • 45 (a)
OneToOne
Species where no ortholog for RALGAPB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALGAPB Gene

ENSEMBL:
Gene Tree for RALGAPB (if available)
TreeFam:
Gene Tree for RALGAPB (if available)

Paralogs for RALGAPB Gene

(1) SIMAP similar genes for RALGAPB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RALGAPB: view

No data available for Paralogs for RALGAPB Gene

Variants for RALGAPB Gene

Sequence variations from dbSNP and Humsavar for RALGAPB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000014901 -- 38,500,173(+) TCAAT(A/C)GTGAT intron-variant
rs1000043174 -- 38,544,278(+) TTTTT(G/T)TCCAG intron-variant
rs1000099956 -- 38,544,554(+) CTGCC(A/G)CCTCC intron-variant
rs1000101179 -- 38,490,604(+) CAGGT(A/T)CAAGC intron-variant
rs1000115260 -- 38,489,692(+) TTCCT(A/G)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGAPB Gene

Variant ID Type Subtype PubMed ID
esv2359941 CNV deletion 18987734
esv2581563 CNV deletion 19546169
esv2624452 CNV deletion 19546169
esv2722399 CNV deletion 23290073
esv2758794 CNV gain 17122850
esv3557054 CNV deletion 23714750
nsv1058457 CNV loss 25217958
nsv1114214 CNV deletion 24896259
nsv1127836 CNV deletion 24896259
nsv179180 CNV deletion 16902084
nsv509769 CNV insertion 20534489

Variation tolerance for RALGAPB Gene

Residual Variation Intolerance Score: 3.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALGAPB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALGAPB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALGAPB Gene

Disorders for RALGAPB Gene

Relevant External Links for RALGAPB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALGAPB

No disorders were found for RALGAPB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALGAPB Gene

Publications for RALGAPB Gene

  1. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PMID: 19520869) Shirakawa R. … Horiuchi H. (J. Biol. Chem. 2009) 2 3 64
  2. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PMID: 16490346) Gridley S. … Lienhard G.E. (Cell. Signal. 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4 64

Products for RALGAPB Gene

Sources for RALGAPB Gene

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