Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

RALGAPB Gene

protein-coding GIFtS: 50
GCID: GC20P037102

Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)

(Previous name: KIAA1219)
(Previous symbol: KIAA1219)

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)¹ ²
KIAA1219¹ ² ³
RalGAPbeta²
Ral GTPase-Activating Protein Subunit Beta²
p170³

External Ids:	HGNC: 29221¹	Entrez Gene: 57148²	Ensembl: ENSG00000170471⁷	UniProtKB: Q86X10³

Export aliases for RALGAPB gene to outside databases

Previous GC identifers: GC20P036535 GC20P033838

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for RALGAPB Gene:

RALGAPB (Ral GTPase activating protein, beta subunit (non-catalytic)) is a protein-coding gene. Diseases associated with RALGAPB include tuberous sclerosis complex, and tuberous sclerosis. GO annotations related to this gene include protein heterodimerization activity and Ral GTPase activator activity.

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10

Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators

for the Ras-like small GTPases RALA and RALB (By similarity)

Gene Wiki entry for RALGAPB (KIAA1219) Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

RefSeq DNA sequence:

NC_000020.11 NT_011362.11 NC_018931.2

Regulatory elements:

Search for regulatory transcription factor binding sites for RALGAPB
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search Chromatin IP Primers for RALGAPB

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALGAPB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23 Ensembl cytogenetic band: 20q11.23 HGNC cytogenetic band: 20q11.23

RALGAPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGAPB gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P037102: view genomic region (about GC identifiers)

Start:	37,101,459 bp from pter	End:	37,207,504 bp from pter
Size:	106,046 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10 (See protein sequence)

Recommended Name: Ral GTPase-activating protein subunit beta

Size: 1494 amino acids; 166799 Da

Subunit: Component of the heterodimeric RalGAP1 complex with RALGAPA1 and of the heterodimeric RalGAP2 complex

with RALGAPA2. Heterodimerization is required for activity (By similarity)

Sequence caution: Sequence=BAA86533.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAC85649.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAB61346.1;

Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAD39096.1; Type=Erroneous

initiation; Note=Translation N-terminally shortened;

Secondary accessions: A2A2E8 Q5TG31 Q8N3D1 Q8WWC0 Q9H3X8 Q9UJR1 Q9ULK1 Q9Y3G9

Alternative splicing: 4 isoforms: Q86X10-1 Q86X10-2 Q86X10-3 Q86X10-4 (Splicing acceptor site is not canonical. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGAPB: NX_Q86X10

Explore proteomics data for RALGAPB at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

See RALGAPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001269846.1 NP_001269847.1 NP_065069.1

ENSEMBL proteins:

ENSP00000262879 ENSP00000380235 ENSP00000380233 ENSP00000416646 ENSP00000442959

ENSP00000380231

Reactome Protein details: Q86X10

RALGAPB Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom MassSpec OriGene Custom Protein Services for RALGAPB
	GenScript Custom Purified and Recombinant Proteins Services for RALGAPB
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

RALGAPB Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for RALGAPB
	Novus Biologicals RALGAPB Antibody
	Abcam antibodies for RALGAPB
	Browse Antibodies at Cloud-Clone Corp.
	Search ThermoFisher Antibodies for RALGAPB
	LSBio Antibodies in human, mouse, rat for RALGAPB

RALGAPB Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for RALGAPB
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RALGAPB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

1 InterPro protein domain:

IPR000331 Rap_GAP_dom

Graphical View of Domain Structure for InterPro Entry Q86X10

ProtoNet protein and cluster: Q86X10

1 Blocks protein domain: IPB000331 Rap/ran-GAP

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10

Similarity: Contains 1 Rap-GAP domain

RALGAPB for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: RLGPB_HUMAN, Q86X10

Function: Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators

for the Ras-like small GTPases RALA and RALB (By similarity)

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	--	--
GO:0005488	binding	--	--
GO:0017123	Ral GTPase activator activity	ISS	--
GO:0046982	protein heterodimerization activity	ISS	--

RALGAPB for ontologies About GeneDecksing

Phenotypes:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ralgapb):

mortality/aging

RALGAPB for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALGAPB

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RALGAPB

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALGAPB

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RALGAPB

miRNA Products:		miRTarBase miRNAs that target RALGAPB: hsa-mir-342-3p (MIRT043719), hsa-mir-328-3p (MIRT043758), hsa-mir-615-3p (MIRT040158), hsa-mir-421 (MIRT039454), hsa-let-7b-5p (MIRT052119), hsa-let-7d-5p (MIRT032129)

		Block miRNA regulation of human, mouse, rat RALGAPB using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RALGAPB (see all 97):
		hsa-miR-26a-2* hsa-miR-642a hsa-miR-485-3p hsa-miR-1245 hsa-miR-30d hsa-miR-219-5p hsa-miR-30a hsa-miR-629*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RALGAPB
		Predesigned siRNA for gene silencing in human, mouse, rat RALGAPB

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RALGAPB

Clone Products:		OriGene clones in human, mouse for RALGAPB (see all 7) OriGene ORF clones in mouse, rat for RALGAPB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RALGAPB (NM_020336)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALGAPB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RALGAPB
		Browse ESI BIO Cell Lines and PureStem Progenitors for RALGAPB

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytosol	2
mitochondrion	1
nucleus	1
peroxisome	1
plasma membrane	1

About this image

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for RALGAPB About

See pathways by source

SuperPath

Contained pathways About

Clathrin derived vesicle budding

Membrane Trafficking

0.32

Translocation of GLUT4 to the Plasma Membrane

0.32

Pathways by source See SuperPaths
Show all pathways

1 Reactome Pathway for RALGAPB

Translocation of GLUT4 to the plasma membrane

RALGAPB for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RALGAPB
Interactions:

Search GeneGlobe Interaction Network for RALGAPB

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for RALGAPB (Q86X10³ ENSP00000262879⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RALGAPA2	Q2PPJ7³, ENSP00000202677⁴	I2D: score=1 STRING: ENSP00000202677
SRC	P12931³, ENSP00000350941⁴	I2D: score=1 STRING: ENSP00000350941
ITSN2	Q9NZM3³	I2D: score=1
RALA	ENSP00000005257⁴	STRING: ENSP00000005257
AKT2	ENSP00000375892⁴	STRING: ENSP00000375892

About this table

Gene Ontology (GO): Selected biological process terms (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0032484	Ral protein signal transduction	IEA	--
GO:0032859	activation of Ral GTPase activity	ISS	--
GO:0032880	regulation of protein localization	--	--
GO:0051056	regulation of small GTPase mediated signal transduction	--	--
GO:0060178	regulation of exocyst localization	IEA	--

RALGAPB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RALGAPB (RLGPB)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for RALGAPB gene (3 alternative transcripts):

NM_001282917.1 NM_001282918.1 NM_020336.3

Unigene Cluster for RALGAPB:

Ral GTPase activating protein, beta subunit (non-catalytic)

Hs.598850 [show with all ESTs]

Unigene Representative Sequence: NM_020336

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000262879 ENST00000397042 ENST00000397040(uc002xiy.1) ENST00000495949

ENST00000438490 ENST00000461423(uc002xja.1) ENST00000461147 ENST00000490114

ENST00000537204 ENST00000397038(uc010zvz.1 uc002xiw.3 uc002xix.3 uc002xiz.3)

miRNA Products:		Block miRNA regulation of human, mouse, rat RALGAPB using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate RALGAPB (see all 97):
		hsa-miR-26a-2* hsa-miR-642a hsa-miR-485-3p hsa-miR-1245 hsa-miR-30d hsa-miR-219-5p hsa-miR-30a hsa-miR-629*

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RALGAPB
		Predesigned siRNA for gene silencing in human, mouse, rat RALGAPB

Clone Products:		OriGene clones in human, mouse for RALGAPB (see all 7) OriGene ORF clones in mouse, rat for RALGAPB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: RALGAPB (NM_020336)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALGAPB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB

Primer Products:		OriGene qPCR primer pairs and template standards for RALGAPB OriGene qSTAR qPCR primer pairs in human, mouse for RALGAPB
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RALGAPB
		QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
		QuantiFast Probe-based Assays in human, mouse, rat RALGAPB

Additional mRNA sequence:

AB621815.1 AK026771.1 AK123576.1 AK125260.1 AK125916.1 AK304242.1 AL132998.1 AL834436.1

BC010916.1 BC018668.1 BC036425.2 BC047482.1 BX641080.1 CR936800.1

17 DOTS entries:

DT.92435970 DT.91963351 DT.453174 DT.97784304 DT.91984412 DT.100724159 DT.40280902 DT.99991846

DT.100703905 DT.120814111 DT.120814140 DT.40123374 DT.92435969 DT.95275801 DT.120814108 DT.92435967

DT.99963796

Selected AceView cDNA sequences (see all 292):

AI017681 AA180094 AL132998 CK904744 AW473729 AW674286 BE673632 BE669526

BM727700 AA495863 AL834436 AI281190 AI767925 BM997147 AA828530 BC018668

BF198044 BQ930118 BE550337 BC047482 AI359832 AA889796 BX375121 BM069766

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPB About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19a	·	19b	^	20	^	21	^
SP1:																																					-										-
SP2:																																															-
SP3:																																															-
SP4:
SP5:

ExUns:	22	^	23	^	24	^	25	^	26	^	27a	·	27b	^	28	^	29	^	30a	·	30b
SP1:											-
SP2:											-
SP3:											-
SP4:
SP5:

ECgene alternative splicing isoforms for RALGAPB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

RALGAPB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: ATTTTTTCTT

About this image

RALGAPB expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database


Eye (Sensory Organs)
Retina

RALGAPB Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RALGAPB Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.598850

UniProtKB/Swiss-Prot: RLGPB_HUMAN, Q86X10

Tissue specificity: Highly expressed in brain, mostly in amygdala

Custom PCR Arrays for RALGAPB

Primer Products:		OriGene qPCR primer pairs and template standards for RALGAPB OriGene qSTAR qPCR primer pairs in human, mouse for RALGAPB
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RALGAPB
		QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
		QuantiFast Probe-based Assays in human, mouse, rat RALGAPB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of animals.

Orthologs for RALGAPB gene from Selected species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ralgapb^{1 , 5}	Ral GTPase activating protein, beta subunit (non-catalytic)^{1, 5}	92.55(n)¹ 97.38(a)¹		2 (78.72 cM)⁵ 228850¹ NM_177658.3¹ NP_808326.2¹ 158409848⁵
chicken (Gallus gallus)	Aves	RALGAPB¹	Ral GTPase activating protein, beta subunit (non-catalytic)	81.92(n) 92.2(a)		419128 NM_001030846.1 NP_001026017.1
lizard (Anolis carolinensis)	Reptilia	RALGAPB⁶	Ral GTPase activating protein, beta subunit (non-c...	88(a)	1 ↔ 1	4(134780928-134841256)
African clawed frog (Xenopus laevis)	Amphibia	Xl.16058²	Xenopus laevis transcribed sequence with weak similarity more	75.75(n)		BJ071291.1
zebrafish (Danio rerio)	Actinopterygii	ralgapb¹	Ral GTPase activating protein, beta subunit (non-catalytic)	69.31(n) 79.36(a)		559303 XM_002662565.3 XP_002662611.2
fruit fly (Drosophila melanogaster)	Insecta	CG34408¹	CG34408	50.64(n) 46.54(a)		31953 NM_132385.2 NP_572613.2
worm (Caenorhabditis elegans)	Secernentea	D2085.5¹	D2085.5	40.9(n) 28.48(a)		3564922 NM_001026883.1 NP_001022054.1

ENSEMBL Gene Tree for RALGAPB (if available)
TreeFam Gene Tree for RALGAPB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for RALGAPB gene

1 SIMAP similar gene for RALGAPB using alignment to 5 protein entries: RLGPB_HUMAN (see all proteins):

DKFZp686N19168

RALGAPB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147786820^1,2	C,F	untested¹	37161494(+)	`CTTAAA/G/TAGATT`	2	K R	mis¹		1		NA	4548
rs6099824^1,2	C,F,A,H	--	37099824(+)	`GCTTTG/TGGACA`	1	--	us2k¹		13		NS NA CSA WA	1274
rs140961426^1,2		--	37100026(+)	`AGTACA/TGGGTT`	1	--	us2k¹		0	--	--	--	--
rs6099828^1,2	C,F,A,H	--	37100072(+)	`CTCCTG/TTCTTT`	1	--	us2k¹		7		NS EA CSA WA	538
rs7509230^1,2	H	--	37100097(+)	`TCAGCA/GCAGCC`	1	--	us2k¹		4		NS EA	420
rs113003724^1,2	F	--	37100145(+)	`TACCCT/AGTTCC`	1	--	us2k¹		1		CSA	2
rs111361016^1,2	C	--	37100188(+)	`AACTTC/TTCCAA`	1	--	us2k¹		2		CSA WA	120
rs1609994^1,2	C,F,A,H	--	37100214(+)	`AAGGTC/TTCCTT`	1	--	us2k¹ tfbs³		20		NS EA NA	2332
rs138564818^1,2		--	37100315(+)	`TCAGCC/TCCTGT`	1	--	us2k¹		0	--	--	--	--
rs6025891^1,2	C,F	--	37100372(+)	`AACTAC/AATAAT`	1	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for RALGAPB (37101459 - 37207504 bp)

Structural Variations
Database of Genomic Variants (DGV) 7 variations for RALGAPB: About this table

Variant ID	Type	Subtype	PubMed ID
esv2359941	CNV	Deletion	18987734
esv2722399	CNV	Deletion	23290073
esv2581563	CNV	Deletion	19546169
esv2624452	CNV	Deletion	19546169
nsv509769	CNV	Insertion	20534489
nsv179180	CNV	Loss	16902084
dgv1327e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RALGAPB

DNA2.0 Custom Variant and Variant Library Synthesis for RALGAPB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

3 diseases for RALGAPB:
About MalaCards

tuberous sclerosis complex tuberous sclerosis malaria

RALGAPB for disorders About GeneDecksing

Export disorders for RALGAPB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for RALGAPB gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with RALGAPB)

Utopia: connect your pdf to the dynamic
world of online information

Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PubMed id 19520869)^{1, 3} Shirakawa R.... Horiuchi H. (J. Biol. Chem. 2009)
Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PubMed id 16490346)^{1, 2} Gridley S.... Lienhard G.E. (Cell. Signal. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (DNA Res. 2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)^{1, 2} Nagase T.... Ohara O. (DNA Res. 1999)
Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)¹ Couzens A.L....Gingras A.C. (Sci Signal 2013)
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)¹ Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 57148	HGNC: 29221	AceView: KIAA1219	Ensembl:ENSG00000170471	euGenes: HUgn57148
ECgene: RALGAPB	H-InvDB: RALGAPB

(According to HUGE)
About This Section

TryGeneCards Plus

HUGE: KIAA1219

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for RALGAPB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RALGAPB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for RALGAPB gene:
Search GeneIP for patents involving RALGAPB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	Browse OriGene Antibodies		OriGene RNAi products in human, mouse, rat for RALGAPB
	OriGene qPCR primer pairs and template standards for RALGAPB		Browse OriGene Protein Over-expression Lysates
	OriGene Custom Mass Spec		OriGene clones in human, mouse for RALGAPB
	OriGene qSTAR qPCR primer pairs in human, mouse for RALGAPB		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	OriGene ORF clones in mouse, rat for RALGAPB		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for RALGAPB		OriGene Custom Protein Services for RALGAPB

	Block miRNA regulation of human, mouse, rat RALGAPB using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing RALGAPB
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALGAPB		Predesigned siRNA for gene silencing in human, mouse, rat RALGAPB
	QuantiFast Probe-based Assays in human, mouse, rat RALGAPB		QuantiTect SYBR Green Assays in human, mouse, rat RALGAPB
	Custom PCR Arrays for RALGAPB		Search Chromatin IP Primers for RALGAPB
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat RALGAPB		Search GeneGlobe Interaction Network for RALGAPB
	Search Regulatory tfbs for RALGAPB

	GenScript Custom Purified and Recombinant Proteins Services for RALGAPB		GenScript cDNA clones with any tag delivered in your preferred vector for RALGAPB
	GenScript Custom Assay Services for RALGAPB		GenScript Custom overexpressing Cell Line Services for RALGAPB
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for RALGAPB (RLGPB)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	Browse Sino Biological cDNA Clones
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	RALGAPB antibodies

	Antibodies for RALGAPB
	See all of Abcam's Antibodies, Kits and Proteins for RALGAPB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for RALGAPB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALGAPB

	Browse SwitchGear 3'UTR luciferase reporter plasmids for RALGAPB
	Browse SwitchGear Promoter luciferase reporter plasmids for RALGAPB

Search ThermoFisher Antibodies for RALGAPB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALGAPB

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALGAPB
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RALGAPB

LSBio Antibodies in human, mouse, rat for RALGAPB

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes RALGAPB gene at Home site.

Version: 3.12.142 28 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

RALGAPB Gene

Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)

Aliases
for RALGAPB gene

Summaries
for RALGAPB gene

Genomic Views
for RALGAPB gene

Proteins
for RALGAPB gene

RALGAPB Human Recombinant Protein Products:

RALGAPB Antibody Products:

RALGAPB Assay Products:

Domains /
Families
for RALGAPB gene

Function
for RALGAPB gene

Localization
for RALGAPB gene

Pathways & Interactions
for RALGAPB gene

Drugs & Compounds
for RALGAPB gene

Transcripts
for RALGAPB gene

Expression
for RALGAPB gene

Orthologs
for RALGAPB gene

Paralogs
for RALGAPB gene

Genomic Variants
for RALGAPB gene

Disorders / Diseases
for RALGAPB gene

Publications
for RALGAPB gene

External Searches for RALGAPB gene

Genome Databases showing RALGAPB gene

Other Databases showing RALGAPB gene

Specialized Databases showing RALGAPB gene

Intellectual Property
for RALGAPB gene

Products
for RALGAPB gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

RALGAPB Gene

Ral GTPase Activating Protein, Beta Subunit (Non-Catalytic)

Aliasesfor RALGAPB gene

Summariesfor RALGAPB gene

Genomic Viewsfor RALGAPB gene

Proteinsfor RALGAPB gene

RALGAPB Human Recombinant Protein Products:

RALGAPB Antibody Products:

RALGAPB Assay Products:

Domains /Familiesfor RALGAPB gene

Functionfor RALGAPB gene

Localizationfor RALGAPB gene

Pathways & Interactionsfor RALGAPB gene

Drugs & Compoundsfor RALGAPB gene

Transcriptsfor RALGAPB gene

Expression for RALGAPB gene

Orthologsfor RALGAPB gene

Paralogsfor RALGAPB gene

Genomic Variantsfor RALGAPB gene

Disorders / Diseasesfor RALGAPB gene

Publicationsfor RALGAPB gene

External Searches for RALGAPB gene

Genome Databases showing RALGAPB gene

Other Databases showing RALGAPB gene

Specialized Databases showing RALGAPB gene

Intellectual Propertyfor RALGAPB gene

Productsfor RALGAPB gene

View Random Gene

Aliases
for RALGAPB gene

Summaries
for RALGAPB gene

Genomic Views
for RALGAPB gene

Proteins
for RALGAPB gene

Domains /
Families
for RALGAPB gene

Function
for RALGAPB gene

Localization
for RALGAPB gene

Pathways & Interactions
for RALGAPB gene

Drugs & Compounds
for RALGAPB gene

Transcripts
for RALGAPB gene

Expression
for RALGAPB gene

Orthologs
for RALGAPB gene

Paralogs
for RALGAPB gene

Genomic Variants
for RALGAPB gene

Disorders / Diseases
for RALGAPB gene

Publications
for RALGAPB gene

Intellectual Property
for RALGAPB gene

Products
for RALGAPB gene