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RALGAPA2 Gene

protein-coding   GIFtS: 49
GCID: GC20M020374

Ral GTPase Activating Protein, Alpha Subunit 2 (Catalytic)

(Previous name: chromosome 20 open reading frame 74)
(Previous symbol: C20orf74)
  Search for RALGAPA2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ral GTPase Activating Protein, Alpha Subunit 2 (Catalytic)1 2     bA287B20.12
C20orf741 2 3     dJ1049G112
250 KDa Substrate Of Akt2 3     dJ1049G11.42
AS2502 3     Ral GTPase-Activating Protein Alpha Subunit 22
p2202 3     Ral GTPase-Activating Protein Subunit Alpha-22
Chromosome 20 Open Reading Frame 741     KIAA12723
RapGAPalpha22     EC 2.7.2.118
Akt Substrate AS2502     EC 5.3.4.18

External Ids:    HGNC: 162071   Entrez Gene: 571862   Ensembl: ENSG000001885597   UniProtKB: Q2PPJ73   

Export aliases for RALGAPA2 gene to outside databases

Previous GC identifer: GC20M020322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RALGAPA2 Gene:
RALGAPA2 (Ral GTPase activating protein, alpha subunit 2 (catalytic)) is a protein-coding gene. GO annotations related to this gene include protein heterodimerization activity and Ral GTPase activator activity. An important paralog of this gene is TSC2.

UniProtKB/Swiss-Prot: RGPA2_HUMAN, Q2PPJ7
Function: Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like
small GTPases RALA and RALB (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NT_011387.9  NC_018931.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RALGAPA2
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for RALGAPA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALGAPA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.22   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.23

RALGAPA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGAPA2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M020374:  view genomic region     (about GC identifiers)

Start:
20,370,196 bp from pter      End:
20,693,266 bp from pter
Size:
323,071 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGPA2_HUMAN, Q2PPJ7 (See protein sequence)
Recommended Name: Ral GTPase-activating protein subunit alpha-2  
Size: 1873 amino acids; 210770 Da
Subunit: Component of the heterodimeric RalGAP2 complex with RALGAPB. Heterodimerization is required for activity
(By similarity)
Sequence caution: Sequence=AAH13749.1; Type=Frameshift; Positions=1600, 1843; Sequence=BAB14290.1; Type=Erroneous
initiation; Sequence=CAI39939.1; Type=Erroneous gene model prediction; Sequence=CAI40814.1; Type=Erroneous gene
model prediction; Sequence=CAI95626.1; Type=Erroneous gene model prediction;
Secondary accessions: Q4VXU6 Q5JUA3 Q5JUA4 Q5T9K3 Q96CX9 Q9BQT7 Q9H9D9 Q9ULE8
Alternative splicing: 3 isoforms:  Q2PPJ7-1   Q2PPJ7-2   Q2PPJ7-3   

Explore the universe of human proteins at neXtProt for RALGAPA2: NX_Q2PPJ7

Explore proteomics data for RALGAPA2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for RALGAPA2 (Q2PPJ7)
     DPKKDVL  LRALLDN 


    See RALGAPA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065076.2  
    ENSEMBL proteins: 
     ENSP00000400085   ENSP00000202677   ENSP00000388695  
    Reactome Protein details: Q2PPJ7

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    Search eBioscience for ELISAs for RALGAPA2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027107 Tuberin/Ral-act_asu
     IPR000331 Rap_GAP_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q2PPJ7

    ProtoNet protein and cluster: Q2PPJ7

    1 Blocks protein domain: IPB000331 Rap/ran-GAP

    UniProtKB/Swiss-Prot: RGPA2_HUMAN, Q2PPJ7
    Similarity: Contains 1 Rap-GAP domain


    Find genes that share domains with RALGAPA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGPA2_HUMAN, Q2PPJ7
    Function: Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like
    small GTPases RALA and RALB (By similarity)

         Enzyme Numbers (IUBMB): EC 2.7.2.112 EC 5.3.4.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005488binding ----
    GO:0017123Ral GTPase activator activity ISS--
    GO:0046982protein heterodimerization activity ISS--
         
    Find genes that share ontologies with RALGAPA2           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ralgapa2):
     homeostasis/metabolism  tumorigenesis 

    Find genes that share phenotypes with RALGAPA2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALGAPA2
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGPA2_HUMAN, Q2PPJ7: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IBA--
    GO:0005886plasma membrane IDA--

    Find genes that share ontologies with RALGAPA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RALGAPA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32


    Find genes that share SuperPaths with RALGAPA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for RALGAPA2
        Translocation of GLUT4 to the plasma membrane


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RALGAPA2
    Interactions:

        Search GeneGlobe Interaction Network for RALGAPA2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for RALGAPA2 (Q2PPJ73 ENSP000002026774) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RALGAPBQ86X103, ENSP000002628794I2D: score=1 STRING: ENSP00000262879
    AKT2ENSP000003758924STRING: ENSP00000375892
    RALAENSP000000052574STRING: ENSP00000005257
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032484Ral protein signal transduction ----
    GO:0032859activation of Ral GTPase activity ISS--
    GO:0051056regulation of small GTPase mediated signal transduction ----
    GO:0060178regulation of exocyst localization ----
    GO:0061024membrane organization TAS--

    Find genes that share ontologies with RALGAPA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALGAPA2 (RGPA2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RALGAPA2 gene: 
    NM_020343.3  

    Unigene Cluster for RALGAPA2:

    Ral GTPase activating protein, alpha subunit 2 (catalytic)
    Hs.472285  [show with all ESTs]
    Unigene Representative Sequence: NM_020343
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430436(uc002wry.3 uc002wrz.3 uc010zsg.2) ENST00000202677
    ENST00000427175(uc002wsa.1) ENST00000495793 ENST00000424981
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RALGAPA2 (see all 57):
    hsa-miR-3164 hsa-miR-128 hsa-miR-301a hsa-miR-488 hsa-miR-570 hsa-miR-374a* hsa-miR-3622b-3p hsa-miR-130b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AK002211.1 AK022881.1 AK026194.1 AK055580.1 AK124584.1 AY007097.1 AY007156.1 BC013749.1 
    BC171842.1 BX640906.1 DQ310704.1 

    20 DOTS entries:

    DT.86855173  DT.109380  DT.95273070  DT.101971281  DT.100754543  DT.106082  DT.40198055  DT.97822292 
    DT.309464  DT.40258054  DT.86855919  DT.100751120  DT.100754544  DT.100754545  DT.75175296  DT.91748269 
    DT.91973559  DT.97776183  DT.97817757  DT.120825842 

    Selected AceView cDNA sequences (see all 241):

    BI712584 AI056199 CA310888 BQ879907 AW296194 BM976674 AA705164 BI962540 
    AI219086 AI373218 BM142036 AI433729 T85728 AI000824 CB305659 AA235486 
    CA776265 BQ016810 BF514693 AA487920 BM503777 AI567741 AI700598 AI989509 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPA2 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41a · 41b
    SP1:              -                                                     -                                   -           -           -     -               
    SP2:                                                                    -                                   -                                             
    SP3:                                                                    -                                   -           -           -                     
    SP4:                                                                                                                                                      
    SP5:                                                                                                        -           -                                 


    ECgene alternative splicing isoforms for RALGAPA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RALGAPA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATAAGGA
    RALGAPA2 Expression
    About this image

    RALGAPA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALGAPA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.472285
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RALGAPA2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgapa21 , 5 Ral GTPase activating protein, alpha subunit 2 (catalytic)1, 5 88.46(n)1
    91.51(a)1
      2 (71.33 cM)5
    2416941  NM_001033348.31  NP_001028520.21 
     1462398795 
    chicken
    (Gallus gallus)
    Aves RALGAPA21 Ral GTPase activating protein, alpha subunit 2 (catalytic) 76.12(n)
    80.1(a)
      421240  XM_004940140.1  XP_004940197.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALGAPA26
    Ral GTPase activating protein, alpha subunit 2 (ca...
    72(a)
    1 ↔ 1
    4(80694045-80893818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.96262 Xenopus laevis transcribed sequence with moderate similarity more 79.8(n)    AW642594.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ralgapa21 Ral GTPase activating protein, alpha subunit 2 (catalytic) 65.77(n)
    68.03(a)
      568210  XM_005158905.1  XP_005158962.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55216
    --
    32(a)
    1 → many
    3R(22792652-22802267)
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.36
    Protein Y18H1A.3 (Y18H1A.3) mRNA, complete cds
    26(a)
    1 → many
    I(700274-715850) WBGene00021209


    ENSEMBL Gene Tree for RALGAPA2 (if available)
    TreeFam Gene Tree for RALGAPA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RALGAPA2 gene
    TSC22  RALGAPA12  
    4 SIMAP similar genes for RALGAPA2 using alignment to 3 protein entries:     RGPA2_HUMAN (see all proteins):
    GARNL2P    RALGAPA1    GARNL1    TSC2

    Find genes that share paralogs with RALGAPA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RALGAPA2 (see all 6028)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs61370141,2
    C,F,H--20369779(+) CCACAC/ACCTGT 1 -- int18Minor allele frequency- A:0.11NS EA WA NA 772
    rs61370151,2
    C,F,H--20369855(+) TGACCG/ACTAGA 1 -- int123Minor allele frequency- A:0.32NS EA NA WA 2764
    rs568140101,2
    C,F--20369897(+) GAGACG/AGAGCA 1 -- int13Minor allele frequency- A:0.06WA CSA 122
    rs1839238571,2
    --20369927(+) GGCTCC/GGATGG 1 -- int10--------
    rs61370161,2
    C,F,H--20369928(+) GCTCGA/GATGGA 1 -- int124Minor allele frequency- G:0.47NS EA NA WA 2764
    rs1883535361,2
    --20369934(+) ATGGAC/TGTTGC 1 -- int10--------
    rs1806786791,2
    --20369935(+) TGGACA/GTTGCG 1 -- int10--------
    rs1857354591,2
    C--20370055(+) TTCCAC/TGTTAG 1 -- int10--------
    rs1898078121,2
    --20370061(+) GTTAGC/GAAACG 1 -- int10--------
    rs1418043791,2
    --20370219(+) GTGAAC/GTTTAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for RALGAPA2 (20370196 - 20620196 bp, first 250kb of RALGAPA2)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RALGAPA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2722282CNV Deletion23290073
    esv2452960CNV Deletion19546169
    esv2722281CNV Deletion23290073
    esv2722283CNV Deletion23290073
    nsv436316CNV Deletion17901297
    nsv3323CNV Insertion18451855
    nsv180272CNV Insertion16902084
    nsv828700CNV Loss20364138
    nsv912812CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RALGAPA2
    DNA2.0 Custom Variant and Variant Library Synthesis for RALGAPA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RALGAPA2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with RALGAPA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PubMed id 16490346)1, 2, 3 Gridley S.... Lienhard G.E. (Cell. Signal. 2006)
    2. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PubMed id 19520869)1, 3 Shirakawa R.... Horiuchi H. (J. Biol. Chem. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2 Nagase T.... Ohara O. (DNA Res. 1999)
    5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer. (PubMed id 22450745)1 Saito R....Horiuchi H. (Oncogene 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57186 HGNC: 16207 AceView: KIAA1272 Ensembl:ENSG00000188559 euGenes: HUgn57186
    ECgene: RALGAPA2 H-InvDB: RALGAPA2

    (According to HUGE)
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    HUGE: KIAA1272

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RALGAPA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RALGAPA2 gene:
    Search GeneIP for patents involving RALGAPA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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