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Aliases for RALGAPA2 Gene

Aliases for RALGAPA2 Gene

  • Ral GTPase Activating Protein Catalytic Alpha Subunit 2 2 3
  • Ral GTPase Activating Protein, Alpha Subunit 2 (Catalytic) 3 5
  • 250 KDa Substrate Of Akt 3 4
  • C20orf74 3 4
  • AS250 3 4
  • P220 3 4
  • Ral GTPase-Activating Protein Alpha Subunit 2 3
  • Chromosome 20 Open Reading Frame 74 2
  • Akt Substrate AS250 3
  • RapGAPalpha2 3
  • DJ1049G11.4 3
  • EC 2.7.2.11 63
  • BA287B20.1 3
  • EC 5.3.4.1 63
  • DJ1049G11 3
  • KIAA1272 4

External Ids for RALGAPA2 Gene

Previous HGNC Symbols for RALGAPA2 Gene

  • C20orf74

Previous GeneCards Identifiers for RALGAPA2 Gene

  • GC20M020322

Summaries for RALGAPA2 Gene

GeneCards Summary for RALGAPA2 Gene

RALGAPA2 (Ral GTPase Activating Protein Catalytic Alpha Subunit 2) is a Protein Coding gene. Among its related pathways are Translocation of GLUT4 to the plasma membrane and Vesicle-mediated transport. GO annotations related to this gene include protein heterodimerization activity and GTPase activator activity. An important paralog of this gene is RAP1GAP.

UniProtKB/Swiss-Prot for RALGAPA2 Gene

  • Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPA2 Gene

Genomics for RALGAPA2 Gene

Regulatory Elements for RALGAPA2 Gene

Enhancers for RALGAPA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RALGAPA2 on UCSC Golden Path with GeneCards custom track

Promoters for RALGAPA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RALGAPA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RALGAPA2 Gene

Chromosome:
20
Start:
20,389,552 bp from pter
End:
20,712,638 bp from pter
Size:
323,087 bases
Orientation:
Minus strand

Genomic View for RALGAPA2 Gene

Genes around RALGAPA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALGAPA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALGAPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGAPA2 Gene

Proteins for RALGAPA2 Gene

  • Protein details for RALGAPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2PPJ7-RGPA2_HUMAN
    Recommended name:
    Ral GTPase-activating protein subunit alpha-2
    Protein Accession:
    Q2PPJ7
    Secondary Accessions:
    • Q4VXU6
    • Q5JUA3
    • Q5JUA4
    • Q5T9K3
    • Q96CX9
    • Q9BQT7
    • Q9H9D9
    • Q9ULE8

    Protein attributes for RALGAPA2 Gene

    Size:
    1873 amino acids
    Molecular mass:
    210770 Da
    Quaternary structure:
    • Component of the heterodimeric RalGAP2 complex with RALGAPB. Heterodimerization is required for activity (By similarity).
    SequenceCaution:
    • Sequence=AAH13749.1; Type=Frameshift; Positions=1600, 1843; Evidence={ECO:0000305}; Sequence=BAB14290.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39939.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40814.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95626.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGAPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGAPA2 Gene

Proteomics data for RALGAPA2 Gene at MOPED

Selected DME Specific Peptides for RALGAPA2 Gene

Post-translational modifications for RALGAPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGAPA2 Gene

Domains & Families for RALGAPA2 Gene

Protein Domains for RALGAPA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RALGAPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2PPJ7

UniProtKB/Swiss-Prot:

RGPA2_HUMAN :
  • Contains 1 Rap-GAP domain.
Domain:
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with RALGAPA2: view

No data available for Gene Families for RALGAPA2 Gene

Function for RALGAPA2 Gene

Molecular function for RALGAPA2 Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

Enzyme Numbers (IUBMB) for RALGAPA2 Gene

Phenotypes for RALGAPA2 Gene

MGI mutant phenotypes for RALGAPA2:
inferred from 1 alleles
GenomeRNAi human phenotypes for RALGAPA2:
genes like me logo Genes that share phenotypes with RALGAPA2: view

Animal Models for RALGAPA2 Gene

MGI Knock Outs for RALGAPA2:

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALGAPA2 Gene

Localization for RALGAPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALGAPA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGAPA2 Gene COMPARTMENTS Subcellular localization image for RALGAPA2 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for RALGAPA2 Gene

Pathways & Interactions for RALGAPA2 Gene

genes like me logo Genes that share pathways with RALGAPA2: view

Pathways by source for RALGAPA2 Gene

1 GeneTex pathway for RALGAPA2 Gene

Interacting Proteins for RALGAPA2 Gene

Gene Ontology (GO) - Biological Process for RALGAPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with RALGAPA2: view

No data available for SIGNOR curated interactions for RALGAPA2 Gene

Drugs & Compounds for RALGAPA2 Gene

(1) Drugs for RALGAPA2 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
RBC8 Pharma 0

(1) ApexBio Compounds for RALGAPA2 Gene

Compound Action Cas Number
RBC8 361185-42-4
genes like me logo Genes that share compounds with RALGAPA2: view

Transcripts for RALGAPA2 Gene

Unigene Clusters for RALGAPA2 Gene

Ral GTPase activating protein, alpha subunit 2 (catalytic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41a · 41b
SP1: - - - - - -
SP2: - -
SP3: - - - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RALGAPA2 Gene

GeneLoc Exon Structure for
RALGAPA2
ECgene alternative splicing isoforms for
RALGAPA2

Expression for RALGAPA2 Gene

mRNA expression in normal human tissues for RALGAPA2 Gene

mRNA differential expression in normal tissues according to GTEx for RALGAPA2 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for RALGAPA2 Gene

This gene is overexpressed in Heart (17.4), Adrenal (14.9), and Plasma (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGAPA2 Gene



SOURCE GeneReport for Unigene cluster for RALGAPA2 Gene Hs.472285

genes like me logo Genes that share expression patterns with RALGAPA2: view

Protein tissue co-expression partners for RALGAPA2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RALGAPA2 Gene

Orthologs for RALGAPA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RALGAPA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RALGAPA2 35
  • 84.11 (n)
  • 86.62 (a)
RALGAPA2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGAPA2 35
  • 90.33 (n)
  • 92.25 (a)
RALGAPA2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralgapa2 35
  • 88.46 (n)
  • 91.51 (a)
Ralgapa2 16
Ralgapa2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RALGAPA2 35
  • 99.55 (n)
  • 99.63 (a)
RALGAPA2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralgapa2 35
  • 87.88 (n)
  • 91.18 (a)
oppossum
(Monodelphis domestica)
Mammalia RALGAPA2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
chicken
(Gallus gallus)
Aves RALGAPA2 35
  • 76.12 (n)
  • 80.1 (a)
RALGAPA2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGAPA2 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgapa2 35
  • 70.33 (n)
  • 74.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9626 35
zebrafish
(Danio rerio)
Actinopterygii ralgapa2 35
  • 65.77 (n)
  • 68.03 (a)
ralgapa2 36
  • 63 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4970 35
fruit fly
(Drosophila melanogaster)
Insecta CG5521 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.3 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for RALGAPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALGAPA2 Gene

ENSEMBL:
Gene Tree for RALGAPA2 (if available)
TreeFam:
Gene Tree for RALGAPA2 (if available)

Paralogs for RALGAPA2 Gene

Paralogs for RALGAPA2 Gene

(4) SIMAP similar genes for RALGAPA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RALGAPA2: view

Variants for RALGAPA2 Gene

Sequence variations from dbSNP and Humsavar for RALGAPA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6137081 - 20,619,341(+) CTCTG(C/T)TCATT nc-transcript-variant, reference, missense
rs1200 -- 20,391,297(-) GCAAA(C/T)GCCCC utr-variant-3-prime
rs967269 -- 20,425,601(-) AAGTC(A/G)CTTTC intron-variant
rs1044869 -- 20,471,669(-) GGCTG(A/G)TGGTG intron-variant
rs1045187 -- 20,390,826(-) CAGTA(G/T)CAGCT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RALGAPA2 Gene

Variant ID Type Subtype PubMed ID
nsv912812 CNV Gain 21882294
nsv180272 CNV Insertion 16902084
nsv3323 CNV Insertion 18451855
nsv828700 CNV Loss 20364138
esv2452960 CNV Deletion 19546169
esv2722281 CNV Deletion 23290073
esv2722282 CNV Deletion 23290073
esv2722283 CNV Deletion 23290073
nsv436316 CNV Deletion 17901297

Variation tolerance for RALGAPA2 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.76; 66.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RALGAPA2 Gene

Disorders for RALGAPA2 Gene

Relevant External Links for RALGAPA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALGAPA2

No disorders were found for RALGAPA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RALGAPA2 Gene

Publications for RALGAPA2 Gene

  1. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PMID: 16490346) Gridley S. … Lienhard G.E. (Cell. Signal. 2006) 2 3 4 67
  2. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PMID: 19520869) Shirakawa R. … Horiuchi H. (J. Biol. Chem. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Heritability and genetic association analysis of cognition in theA Diabetes Heart Study. (PMID: 24684796) Cox A.J. … Bowden D.W. (Neurobiol. Aging 2014) 3

Products for RALGAPA2 Gene

Sources for RALGAPA2 Gene

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