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Aliases for RALGAPA2 Gene

Aliases for RALGAPA2 Gene

  • Ral GTPase Activating Protein, Alpha Subunit 2 (Catalytic) 2 3
  • 250 KDa Substrate Of Akt 3 4
  • C20orf74 3 4
  • AS250 3 4
  • P220 3 4
  • Ral GTPase-Activating Protein Alpha Subunit 2 3
  • Ral GTPase-Activating Protein Subunit Alpha-2 3
  • Chromosome 20 Open Reading Frame 74 2
  • Akt Substrate AS250 3
  • RapGAPalpha2 3
  • DJ1049G11.4 3
  • EC 2.7.2.11 63
  • BA287B20.1 3
  • EC 5.3.4.1 63
  • DJ1049G11 3
  • KIAA1272 4

External Ids for RALGAPA2 Gene

Previous HGNC Symbols for RALGAPA2 Gene

  • C20orf74

Previous GeneCards Identifiers for RALGAPA2 Gene

  • GC20M020322

Summaries for RALGAPA2 Gene

GeneCards Summary for RALGAPA2 Gene

RALGAPA2 (Ral GTPase Activating Protein, Alpha Subunit 2 (Catalytic)) is a Protein Coding gene. Among its related pathways are Clathrin derived vesicle budding and Clathrin derived vesicle budding. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is RALGAPA1.

UniProtKB/Swiss-Prot for RALGAPA2 Gene

  • Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALGAPA2 Gene

Genomics for RALGAPA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RALGAPA2 Gene

Start:
20,389,552 bp from pter
End:
20,712,638 bp from pter
Size:
323,087 bases
Orientation:
Minus strand

Genomic View for RALGAPA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALGAPA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALGAPA2 Gene

No data available for Regulatory Elements for RALGAPA2 Gene

Proteins for RALGAPA2 Gene

  • Protein details for RALGAPA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2PPJ7-RGPA2_HUMAN
    Recommended name:
    Ral GTPase-activating protein subunit alpha-2
    Protein Accession:
    Q2PPJ7
    Secondary Accessions:
    • Q4VXU6
    • Q5JUA3
    • Q5JUA4
    • Q5T9K3
    • Q96CX9
    • Q9BQT7
    • Q9H9D9
    • Q9ULE8

    Protein attributes for RALGAPA2 Gene

    Size:
    1873 amino acids
    Molecular mass:
    210770 Da
    Quaternary structure:
    • Component of the heterodimeric RalGAP2 complex with RALGAPB. Heterodimerization is required for activity (By similarity).
    SequenceCaution:
    • Sequence=AAH13749.1; Type=Frameshift; Positions=1600, 1843; Evidence={ECO:0000305}; Sequence=BAB14290.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI39939.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI40814.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI95626.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RALGAPA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALGAPA2 Gene

Proteomics data for RALGAPA2 Gene at MOPED

Selected DME Specific Peptides for RALGAPA2 Gene

Post-translational modifications for RALGAPA2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALGAPA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for RALGAPA2 Gene

Protein Domains for RALGAPA2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RALGAPA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2PPJ7

UniProtKB/Swiss-Prot:

RGPA2_HUMAN :
  • Q2PPJ7
Domain:
  • Contains 1 Rap-GAP domain.
genes like me logo Genes that share domains with RALGAPA2: view

No data available for Gene Families for RALGAPA2 Gene

Function for RALGAPA2 Gene

Molecular function for RALGAPA2 Gene

UniProtKB/Swiss-Prot Function: Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

Enzyme Numbers (IUBMB) for RALGAPA2 Gene

Gene Ontology (GO) - Molecular Function for RALGAPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity ISS --
GO:0005488 binding --
GO:0046982 protein heterodimerization activity ISS --
genes like me logo Genes that share ontologies with RALGAPA2: view

Phenotypes for RALGAPA2 Gene

genes like me logo Genes that share phenotypes with RALGAPA2: view

Animal Model Products

CRISPR Products

miRNA for RALGAPA2 Gene

miRTarBase miRNAs that target RALGAPA2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGAPA2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RALGAPA2 Gene

Localization for RALGAPA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALGAPA2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALGAPA2 Gene COMPARTMENTS Subcellular localization image for RALGAPA2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for RALGAPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RALGAPA2: view

Pathways for RALGAPA2 Gene

genes like me logo Genes that share pathways with RALGAPA2: view

Pathways by source for RALGAPA2 Gene

Interacting Proteins for RALGAPA2 Gene

Gene Ontology (GO) - Biological Process for RALGAPA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051056 regulation of small GTPase mediated signal transduction --
GO:0061024 membrane organization TAS --
GO:0090630 activation of GTPase activity ISS --
genes like me logo Genes that share ontologies with RALGAPA2: view

Transcripts for RALGAPA2 Gene

Unigene Clusters for RALGAPA2 Gene

Ral GTPase activating protein, alpha subunit 2 (catalytic):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RALGAPA2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for RALGAPA2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALGAPA2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32 ^ 33a · 33b · 33c ^ 34a · 34b ^ 35a · 35b ^ 36a · 36b ^ 37a · 37b ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41a · 41b
SP1: - - - - - -
SP2: - -
SP3: - - - -
SP4:
SP5: - -
SP6:
SP7:
SP8:
SP9:

Relevant External Links for RALGAPA2 Gene

GeneLoc Exon Structure for
RALGAPA2
ECgene alternative splicing isoforms for
RALGAPA2

Expression for RALGAPA2 Gene

mRNA expression in normal human tissues for RALGAPA2 Gene

mRNA differential expression in normal tissues according to GTEx for RALGAPA2 Gene

This gene is overexpressed in Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALGAPA2 Gene

SOURCE GeneReport for Unigene cluster for RALGAPA2 Gene Hs.472285

genes like me logo Genes that share expressions with RALGAPA2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RALGAPA2 Gene

Orthologs for RALGAPA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RALGAPA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALGAPA2 35
  • 99.55 (n)
  • 99.63 (a)
RALGAPA2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALGAPA2 35
  • 84.11 (n)
  • 86.62 (a)
RALGAPA2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALGAPA2 35
  • 90.33 (n)
  • 92.25 (a)
RALGAPA2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralgapa2 35
  • 88.46 (n)
  • 91.51 (a)
Ralgapa2 16
Ralgapa2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALGAPA2 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ralgapa2 35
  • 87.88 (n)
  • 91.18 (a)
chicken
(Gallus gallus)
Aves RALGAPA2 35
  • 76.12 (n)
  • 80.1 (a)
RALGAPA2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALGAPA2 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9626 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ralgapa2 35
  • 70.33 (n)
  • 74.29 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4970 35
zebrafish
(Danio rerio)
Actinopterygii ralgapa2 35
  • 65.77 (n)
  • 68.03 (a)
ralgapa2 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG5521 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y18H1A.3 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for RALGAPA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALGAPA2 Gene

ENSEMBL:
Gene Tree for RALGAPA2 (if available)
TreeFam:
Gene Tree for RALGAPA2 (if available)

Paralogs for RALGAPA2 Gene

Paralogs for RALGAPA2 Gene

Selected SIMAP similar genes for RALGAPA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with RALGAPA2: view

Variants for RALGAPA2 Gene

Sequence variations from dbSNP and Humsavar for RALGAPA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1200 -- 20,391,297(-) GCAAA(C/T)GCCCC utr-variant-3-prime
rs720332 -- 20,669,984(+) CAAGA(A/G)CCATC intron-variant
rs724280 -- 20,667,131(+) ATATA(C/G)AAAAC intron-variant
rs731866 -- 20,658,401(+) CTGGG(A/G)CAAAT intron-variant
rs742980 -- 20,595,183(+) ACAGC(A/C)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALGAPA2 Gene

Variant ID Type Subtype PubMed ID
nsv912812 CNV Gain 21882294
nsv180272 CNV Insertion 16902084
nsv3323 CNV Insertion 18451855
nsv828700 CNV Loss 20364138
esv2452960 CNV Deletion 19546169
esv2722281 CNV Deletion 23290073
esv2722282 CNV Deletion 23290073
esv2722283 CNV Deletion 23290073
nsv436316 CNV Deletion 17901297

Relevant External Links for RALGAPA2 Gene

HapMap Linkage Disequilibrium report
RALGAPA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALGAPA2 Gene

Disorders for RALGAPA2 Gene

No disorders were found for RALGAPA2 Gene.

No data available for UniProtKB/Swiss-Prot for RALGAPA2 Gene

Publications for RALGAPA2 Gene

  1. Adipocytes contain a novel complex similar to the tuberous sclerosis complex. (PMID: 16490346) Gridley S. … Lienhard G.E. (Cell. Signal. 2006) 2 3 4
  2. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PMID: 19520869) Shirakawa R. … Horiuchi H. (J. Biol. Chem. 2009) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for RALGAPA2 Gene

  • antibodies-online proteins for RALGAPA2
  • antibodies-online antibodies for RALGAPA2
  • antibodies-online kits for RALGAPA2

Sources for RALGAPA2 Gene

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