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RALGAPA1 Gene

protein-coding   GIFtS: 53
GCID: GC14M036008

Ral GTPase Activating Protein, Alpha Subunit 1 (Catalytic)

(Previous names: GTPase activating RANGAP domain-like 1, GTPase activating...)
(Previous symbol: GARNL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ral GTPase Activating Protein, Alpha Subunit 1 (Catalytic)1 2     GAP-Related Interacting Protein To E121 2
GARNL11 2 3 5     p2402 3
Tuberin-Like Protein 11 2 3     KIAA08843 5
GRIPE2 3 5     RalGAPalpha12
TULIP12 3 5     Ral GTPase-Activating Protein Subunit Alpha-12
GTPase Activating RANGAP Domain-Like 11 2     GAP-Related-Interacting Partner To E123
GTPase Activating Rap/RanGAP Domain-Like 11 2     GTPase-Activating Rap/Ran-GAP Domain-Like 13

External Ids:    HGNC: 177701   Entrez Gene: 2539592   Ensembl: ENSG000001743737   OMIM: 6088845   UniProtKB: Q6GYQ03   

Export aliases for RALGAPA1 gene to outside databases

Previous GC identifers: GC14M035080 GC14M016121


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RALGAPA1 Gene:
RALGAPA1 (Ral GTPase activating protein, alpha subunit 1 (catalytic)) is a protein-coding gene. Diseases associated with RALGAPA1 include newcastle disease, and coloboma. GO annotations related to this gene include protein heterodimerization activity and Ral GTPase activator activity. An important paralog of this gene is RALGAPA2.

UniProtKB/Swiss-Prot: RGPA1_HUMAN, Q6GYQ0
Function: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like
small GTPases RALA and RALB (By similarity)

Gene Wiki entry for RALGAPA1 (GARNL1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RALGAPA1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRALGAPA1 promoter sequence
   Search Chromatin IP Primers for RALGAPA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALGAPA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q13.2   Ensembl cytogenetic band:  14q13.2   HGNC cytogenetic band: 14q13.2

RALGAPA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALGAPA1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M036008:  view genomic region     (about GC identifiers)

Start:
36,007,558 bp from pter      End:
36,278,510 bp from pter
Size:
270,953 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RGPA1_HUMAN, Q6GYQ0 (See protein sequence)
Recommended Name: Ral GTPase-activating protein subunit alpha-1  
Size: 2036 amino acids; 229832 Da
Subunit: Component of the heterodimeric RalGAP1 complex with RALGAPB. Heterodimerization is required for activity.
Interacts with the HLH region of TCF3/isoform E12 (By similarity)
Sequence caution: Sequence=BAC86772.1; Type=Erroneous initiation;
Secondary accessions: A6NMA4 C5NU19 O94960 Q6GYP9 Q6ZT23 Q86YF3 Q86YF5 Q8ND69
Alternative splicing: 6 isoforms:  Q6GYQ0-1   Q6GYQ0-2   Q6GYQ0-3   Q6GYQ0-4   Q6GYQ0-5   Q6GYQ0-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RALGAPA1: NX_Q6GYQ0

Explore proteomics data for RALGAPA1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RALGAPA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001269972.1  NP_001269973.1  NP_055805.1  NP_919277.2  

    ENSEMBL proteins: 
     ENSP00000450574   ENSP00000374348   ENSP00000302647   ENSP00000451133   ENSP00000371803  
     ENSP00000451877   ENSP00000258840  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR027107 Tuberin/Ral-act_asu
     IPR000331 Rap_GAP_dom
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6GYQ0

    ProtoNet protein and cluster: Q6GYQ0

    1 Blocks protein domain: IPB000331 Rap/ran-GAP

    UniProtKB/Swiss-Prot: RGPA1_HUMAN, Q6GYQ0
    Similarity: Contains 1 Rap-GAP domain


    RALGAPA1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RGPA1_HUMAN, Q6GYQ0
    Function: Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like
    small GTPases RALA and RALB (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IBA--
    GO:0005488binding ----
    GO:0017123Ral GTPase activator activity ISS--
    GO:0046982protein heterodimerization activity IPI19520869
         
    RALGAPA1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RALGAPA1:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALGAPA1
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    miRNA
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    miRTarBase miRNAs that target RALGAPA1:
    hsa-mir-17-5p (MIRT051044)

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    Selected qRT-PCR Assays for microRNAs that regulate RALGAPA1 (see all 10):
    hsa-miR-577 hsa-miR-206 hsa-miR-222 hsa-miR-1 hsa-miR-221 hsa-miR-199a-5p hsa-miR-466 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidRALGAPA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RGPA1_HUMAN, Q6GYQ0: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated to the nucleus, when
    associated with TCF3/E12 (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    nucleus4
    cytosol3
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm ISS--
    GO:0005739mitochondrion ----
    GO:0005829cytosol IBA--

    RALGAPA1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RALGAPA1 About    
    See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for RALGAPA1
        Integrated Breast Cancer Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RALGAPA1
    Interactions:

        Search GeneGlobe Interaction Network for RALGAPA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for RALGAPA1 (Q6GYQ03 ENSP000003026474) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    TERF1P542743, ENSP000002766034I2D: score=1 STRING: ENSP00000276603
    TCF3P159233, ENSP000002629654I2D: score=3 STRING: ENSP00000262965
    TERF2Q155543, ENSP000002549424I2D: score=1 STRING: ENSP00000254942
    ITSN2Q9NZM33I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0032859activation of Ral GTPase activity ISS--
    GO:0043547positive regulation of GTPase activity IBA--
    GO:0051056regulation of small GTPase mediated signal transduction ----

    RALGAPA1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALGAPA1 (RGPA1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RALGAPA1 gene (4 alternative transcripts): 
    NM_001283043.1  NM_001283044.1  NM_014990.1  NM_194301.2  

    Unigene Cluster for RALGAPA1:

    Ral GTPase activating protein, alpha subunit 1 (catalytic)
    Hs.113150  [show with all ESTs]
    Unigene Representative Sequence: AY596970
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000554573 ENST00000389698(uc010amp.3 uc001wti.3 uc010tpv.2)
    ENST00000307138(uc001wtj.3) ENST00000554259 ENST00000556106 ENST00000382366
    ENST00000553892 ENST00000554355 ENST00000556837 ENST00000554652(uc001wtk.1)
    ENST00000557638 ENST00000556839 ENST00000553917 ENST00000554704 ENST00000557069
    ENST00000557104 ENST00000555828 ENST00000556192
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RALGAPA1 (see all 10):
    hsa-miR-577 hsa-miR-206 hsa-miR-222 hsa-miR-1 hsa-miR-221 hsa-miR-199a-5p hsa-miR-466 hsa-miR-199b-5p
    SwitchGear 3'UTR luciferase reporter plasmidRALGAPA1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB020691.1 AB511280.1 AF085938.1 AK022988.1 AK126975.1 AL050050.1 AL834362.1 AY596970.1 
    AY596971.1 BC016305.1 BC042013.1 BC042045.1 BC150596.1 DQ786317.1 

    23 DOTS entries:

    DT.100816161  DT.97782725  DT.445190  DT.95169518  DT.91895210  DT.100032428  DT.86837497  DT.120754087 
    DT.40257201  DT.95183135  DT.120754088  DT.121145677  DT.40108199  DT.438144  DT.86854919  DT.91667406 
    DT.91668571  DT.92429790  DT.120754073  DT.75101073  DT.95278378  DT.95363637  DT.97857780 

    Selected AceView cDNA sequences (see all 145):

    BM670224 F09823 AA747899 BC016305 Z39869 AA323190 AW969055 CK821147 
    BI792920 AL834362 BX486305 CK821146 AW293383 BI914051 NM_014990 AI052024 
    AA939262 NM_015639 AA504549 AK126975 N59461 AA938311 CR599879 NM_194301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RALGAPA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTATTTAATA
    RALGAPA1 Expression
    About this image


    RALGAPA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    RALGAPA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALGAPA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113150

    UniProtKB/Swiss-Prot: RGPA1_HUMAN, Q6GYQ0
    Tissue specificity: Widely expressed

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RALGAPA1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralgapa11 , 5 Ral GTPase activating protein, alpha subunit 11, 5 90.85(n)1
    94.49(a)1
      12 (24.06 cM)5
    567841  NM_001003719.21  NP_001003719.11 
     556029295 
    chicken
    (Gallus gallus)
    Aves RALGAPA11 Ral GTPase activating protein, alpha subunit 1 (catalytic) 81.47(n)
    88.13(a)
      423327  NM_001277447.1  NP_001264376.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    89(a)
    86(a)
    1 ↔ many
    1 ↔ many
    AAWZ02034921(4101-25073)
    1(24059680-24172255)
    zebrafish
    (Danio rerio)
    Actinopterygii BM890464.12   -- 75.86(n)    BM890464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG55211 CG5521 48.68(n)
    42.41(a)
      43242  NM_001170277.2  NP_001163748.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y18H1A.36
    Protein Y18H1A.3 (Y18H1A.3) mRNA, complete cds
    26(a)
    1 → many
    I(700274-715850) WBGene00021209


    ENSEMBL Gene Tree for RALGAPA1 (if available)
    TreeFam Gene Tree for RALGAPA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RALGAPA1 gene
    RALGAPA22  TSC22  
    3 SIMAP similar genes for RALGAPA1 using alignment to 4 protein entries:     RGPA1_HUMAN (see all proteins):
    GARNL2P    GARNL1    RALGAPA2

    RALGAPA1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RALGAPA1
    PGOHUM00000260533


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RALGAPA1 (see all 4536)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs609036561,2
    C--16320843(+) AAAAA-/A/AAA 
    AAAAAAAA
    GAATG
    2 -- int11NA 2
    rs2007578561,2
    C--36007123(+) ACAAA-/ACAAAAT 2 -- int10--------
    rs1380079831,2
    --36007259(+) GACTCC/TGTCTC 2 -- int10--------
    rs1841324521,2
    --36007551(+) AATCAA/GCACTC 2 -- int10--------
    rs557337011,2
    C--36007624(+) CCACTA/GTTACA 2 -- ut310--------
    rs1410378441,2
    C--36007645(+) ACTACA/GTGAAT 2 -- ut310--------
    rs1886449191,2
    C--36007675(+) TTTACA/GGTTTG 2 -- ut310--------
    rs1432875901,2
    C--36007704(+) ACATGC/TAGTTA 2 -- ut310--------
    rs1931658491,2
    --36008424(+) CAATTG/TTATTT 2 -- ut310--------
    rs2009167731,2
    C--36008632(+) TTCTC-/AAAT  
            
    AAATG
    2 -- ut310--------

    HapMap Linkage Disequilibrium report for RALGAPA1 (36007558 - 36257558 bp, first 250kb of RALGAPA1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RALGAPA1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2549342CNV Deletion19546169
    esv272125CNV Insertion20981092
    nsv507742CNV Insertion20534489
    nsv1241CNV Insertion18451855
    nsv901631CNV Loss21882294
    dgv1873n71CNV Loss21882294
    nsv901630CNV Loss21882294
    dgv1875n71CNV Loss21882294
    dgv1874n71CNV Loss21882294
    nsv901623CNV Loss21882294

    Human Gene Mutation Database (HGMD): RALGAPA1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RALGAPA1
    DNA2.0 Custom Variant and Variant Library Synthesis for RALGAPA1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 608884    OMIM disorders: --

    6 diseases for RALGAPA1:    
    About MalaCards
    newcastle disease    coloboma    tuberous sclerosis    breast cancer
    cerebritis    malaria


    RALGAPA1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): RALGAPA1
    Human Genome Epidemiology (HuGE) Navigator: RALGAPA1 (1 document)

    Export disorders for RALGAPA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RALGAPA1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with RALGAPA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. (PubMed id 19520869)1, 2, 3 Shirakawa R.... Horiuchi H. (J. Biol. Chem. 2009)
    2. Cloning, genomic structure and expression profile of TULIP1 (GARNL1), a brain-expressed candidate gene for 14q13-linked neurological phenotypes and its murine homolog. (PubMed id 15498464)1, 2, 9 Schwarzbraun T.... Petek E. (Genomics 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2 Nagase T.... Ohara O. (DNA Res. 1998)
    7. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    8. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 253959 HGNC: 17770 AceView: GARNL1 Ensembl:ENSG00000174373 euGenes: HUgn253959
    ECgene: RALGAPA1 H-InvDB: RALGAPA1

    (According to HUGE)
    About This Section

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    HUGE: KIAA0884

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RALGAPA1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for RALGAPA1 gene:
    Search GeneIP for patents involving RALGAPA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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