Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RALBP1 Gene

protein-coding   GIFtS: 67
GCID: GC18P009465

RalA Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RalA Binding Protein 11 2     RLIP12 3
RLIP762 3 5     DNP-SG ATPase2 3
Dinitrophenyl S-Glutathione ATPase2 3     RIP12
Ral-Interacting Protein 12 3     RalA-Binding Protein 12
76 KDa Ral-Interacting Protein2 3     RalBP13

External Ids:    HGNC: 98411   Entrez Gene: 109282   Ensembl: ENSG000000177977   OMIM: 6058015   UniProtKB: Q153113   

Export aliases for RALBP1 gene to outside databases

Previous GC identifer: GC18P009629


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RALBP1 Gene:
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein
RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms,
which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is
activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 (PubMed 12888294)).(supplied by OMIM, Nov 2010)

GeneCards Summary for RALBP1 Gene:
RALBP1 (ralA binding protein 1) is a protein-coding gene. Diseases associated with RALBP1 include kidney cancer, and lung cancer. GO annotations related to this gene include Rac GTPase binding and GTPase activator activity. An important paralog of this gene is ARHGAP30.

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates
ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major
ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze
transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and
also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin

Gene Wiki entry for RALBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000018.10  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RALBP1 gene promoter:
         AREB6   Sp1   p53   AP-2beta   AP-2gamma   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRALBP1 promoter sequence
   Search Chromatin IP Primers for RALBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.22

RALBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALBP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009465:  view genomic region     (about GC identifiers)

Start:
9,475,007 bp from pter      End:
9,538,114 bp from pter
Size:
63,108 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311 (See protein sequence)
Recommended Name: RalA-binding protein 1  
Size: 655 amino acids; 76063 Da
Subunit: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this
does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and
CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis
3 PDB 3D structures from and Proteopedia for RALBP1:
2KWH (3D)        2KWI (3D)        2MBG (3D)    
Secondary accessions: D3DUI0

Explore the universe of human proteins at neXtProt for RALBP1: NX_Q15311

Explore proteomics data for RALBP1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys161
  • Modification sites at PhosphoSitePlus

  • See RALBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006779.1  
    ENSEMBL proteins: 
     ENSP00000019317   ENSP00000463693   ENSP00000372924   ENSP00000411556   ENSP00000462549  
    Reactome Protein details: Q15311

    RALBP1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant RALBP1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for RALBP1
    OriGene Protein Over-expression Lysate for RALBP1
    OriGene MassSpec for RALBP1
    OriGene Custom Protein Services for RALBP1
    GenScript Custom Purified and Recombinant Proteins Services for RALBP1
    Novus Biologicals RALBP1 Protein
    Novus Biologicals RALBP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RALBP1

    RALBP1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RALBP1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for RALBP1 
    OriGene Antibodies for RALBP1
    OriGene Custom Antibody Services for RALBP1
    Novus Biologicals RALBP1 Antibodies
    Abcam antibodies for RALBP1
    Cloud-Clone Corp. Antibodies for RALBP1
    ThermoFisher Antibody for RALBP1
    LSBio Antibodies in human, mouse, rat for RALBP1

    RALBP1 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of RALBP1
    OriGene Custom Assay Services for RALBP1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RALBP1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RALBP1
    Cloud-Clone Corp. CLIAs for RALBP1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q15311

    ProtoNet protein and cluster: Q15311

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
    Similarity: Contains 1 Rho-GAP domain


    RALBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBP1_HUMAN, Q15311
    Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates
    ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major
    ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze
    transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
    Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and
    also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IDA7673236
    GO:0005515protein binding IPI17703191
    GO:0016887ATPase activity IDA10924126
    GO:0017160Ral GTPase binding IPI7673236
    GO:0030675Rac GTPase activator activity IDA7673236
         
    RALBP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RALBP1:
     Big cells  Increased G2M DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ralbp1):
     behavior/neurological  cellular  integument  mortality/aging  nervous system 

    RALBP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALBP1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RALBP1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALBP1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RALBP1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RALBP1:
    hsa-mir-10a-5p (MIRT047750), hsa-mir-10b-5p (MIRT047496), hsa-mir-615-3p (MIRT040266), hsa-mir-125a-5p (MIRT045735), hsa-mir-1914-5p (MIRT035794)

    Block miRNA regulation of human, mouse, rat RALBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RALBP1 (see all 69):
    hsa-miR-3194-5p hsa-miR-607 hsa-miR-3916 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-4293 hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRALBP1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RALBP1
    Predesigned siRNA for gene silencing in human, mouse, rat RALBP1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RALBP1

    Clone
    Products:
         
    OriGene clones in human, mouse for RALBP1 (see all 7)
    OriGene ORF clones in mouse, rat for RALBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RALBP1 (NM_006788)
    Sino Biological Human cDNA Clone for RALBP1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALBP1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RALBP1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RALBP1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALBP1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RBP1_HUMAN, Q15311: Membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA10924126

    RALBP1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RALBP1 About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43
    3GPCR Pathway
    Ras Pathway0.73
    4Signaling by GPCR
    Signal Transduction0.58
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RALBP1
        FGF Pathway
    Molecular Mechanisms of Cancer
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for RALBP1
        Cytoskeletal Signaling

    5 GeneGo (Thomson Reuters) Pathways for RALBP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Cross-talk between Ras-family GTPases
    Cytoskeleton remodeling RalB regulation pathway
    G-protein signaling Regulation of CDC42 activity
    Cytoskeleton remodeling RalA regulation pathway

    4 BioSystems Pathways for RALBP1
        EGFR1 Signaling Pathway
    RalA downstream regulated genes
    Regulation of CDC42 activity
    Regulation of RAC1 activity


    1 Reactome Pathway for RALBP1
        Rho GTPase cycle

    4 PharmGKB Pathways for RALBP1
        Carbamazepine Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Vinka Alkaloid Pathway, Pharmacokinetics

    3 Kegg Pathways  (Kegg details for RALBP1):
        Ras signaling pathway
    Pathways in cancer
    Pancreatic cancer


    RALBP1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RALBP1
    Interactions:

        GeneGlobe Interaction Network for RALBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RALBP1 (Q153111, 2, 3 ENSP000000193174) via UniProtKB, MINT, STRING, and/or I2D (see all 149)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL20P785561, 2, 3, ENSP000003516714EBI-749285,EBI-3913209 MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000351671
    RALBP112342, 3, ENSP000002725194MINT-68413 I2D: score=7 STRING: ENSP00000272519
    HOOK2Q96ED92, 3, ENSP000003807854MINT-67479 I2D: score=5 STRING: ENSP00000380785
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA10924126
    GO:0006810transport IDA10924126
    GO:0006935chemotaxis TAS10848592
    GO:0007165signal transduction TAS7673236
    GO:0007264small GTPase mediated signal transduction TAS--

    RALBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALBP1 (RBP1)

    2 HMDB Compounds for RALBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for RALBP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-(2,4-dinitrophenyl)glutathione 78.4 2 2143605 (1), 12545192 (1)
    4-hydroxynonenal 71.4 23 12527936 (3), 12422239 (2), 11522795 (2), 15950949 (1) (see all 9)
    doxorubicin 60.6 71 11437348 (5), 12527936 (4), 10924126 (4), 12545192 (4) (see all 16)
    8-azido-atp 59.3 1 9548754 (1)
    atp 32.5 31 12422239 (4), 7907606 (4), 11300797 (3), 15386349 (3) (see all 9)
    colchicine 32.4 1 10079207 (1)
    vinorelbine 25.8 7 15705900 (5)
    daunorubicin 19.2 3 11732624 (1)
    vinblastine 15.3 1 15705900 (1)
    threonine 15 2 18473820 (1), 17047155 (1)



    RALBP1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RALBP1 gene: 
    NM_006788.3  

    Unigene Cluster for RALBP1:

    RalA binding protein 1
    Hs.528993  [show with all ESTs]
    Unigene Representative Sequence: NM_006788
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000019317(uc002kob.3) ENST00000585015 ENST00000383432(uc002koc.3)
    ENST00000458039 ENST00000577221
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RALBP1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RALBP1 (see all 69):
    hsa-miR-3194-5p hsa-miR-607 hsa-miR-3916 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-4293 hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidRALBP1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RALBP1
    Predesigned siRNA for gene silencing in human, mouse, rat RALBP1
    Clone
    Products:
         
    OriGene clones in human, mouse for RALBP1 (see all 7)
    OriGene ORF clones in mouse, rat for RALBP1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RALBP1 (NM_006788)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RALBP1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALBP1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for RALBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for RALBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RALBP1
      QuantiTect SYBR Green Assays in human, mouse, rat RALBP1
      QuantiFast Probe-based Assays in human, mouse, rat RALBP1

    Additional mRNA sequence: 

    AB209924.1 AK300845.1 AY517554.1 BC013126.1 L42542.1 

    13 DOTS entries:

    DT.92438991  DT.447437  DT.121085537  DT.95347147  DT.99985745  DT.100813889  DT.100813892  DT.92438996 
    DT.95106068  DT.101983390  DT.75143769  DT.92439007  DT.121085541 

    Selected AceView cDNA sequences (see all 300):

    AI002738 BQ717336 AW151068 N22101 CD364583 AI222761 F01969 BC013126 
    AW016627 BX353517 BU193315 BU742671 CF125335 BP335883 BQ086280 CA422971 
    BM683246 CK822954 AW207118 AA211324 AI362041 BM739309 BU729728 AI560672 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                          
    SP2:        -     -     -                                                                     
    SP3:                          -                                                               
    SP4:                    -     -                                                               


    ECgene alternative splicing isoforms for RALBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RALBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RALBP1 Expression
    About this image


    RALBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    RALBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528993

    UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
    Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes

        Custom PCR Arrays for RALBP1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for RALBP1
    OriGene qSTAR qPCR primer pairs in human, mouse for RALBP1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RALBP1
    QuantiTect SYBR Green Assays in human, mouse, rat RALBP1
    QuantiFast Probe-based Assays in human, mouse, rat RALBP1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALBP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RALBP1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralbp11 , 5 ralA binding protein 11, 5 88.32(n)1
    92.75(a)1
      17 (35.26 cM)5
    197651  NM_001198949.11  NP_001185878.11 
     658484335 
    chicken
    (Gallus gallus)
    Aves RALBP11 ralA binding protein 1 83.39(n)
    93.49(a)
      429466  NM_001031575.1  NP_001026746.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALBP16
    ralA binding protein 1
    89(a)
    1 ↔ 1
    GL343319.1(580199-614934)
    African clawed frog
    (Xenopus laevis)
    Amphibia rlip1-A-prov2 RalB-binding protein 77.45(n)    AJ304845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ralbp11 ralA binding protein 1 70.7(n)
    76.86(a)
      404612  NM_207080.1  NP_996963.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rlip3 RAL GTPase activator 34(a)   93B4   --
    worm
    (Caenorhabditis elegans)
    Secernentea rlbp-16
    Protein RLBP-1, isoform a (rlbp-1) mRNA, complete ...
    21(a)
    1 ↔ 1
    I(7683341-7694212) WBGene00011970
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGD16
    GTPase-activating protein (RhoGAP) for Rho3p and R...
    7(a)
    1 → many
    II(732639-734639) YBR260C


    ENSEMBL Gene Tree for RALBP1 (if available)
    TreeFam Gene Tree for RALBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for RALBP1 gene
    ARHGAP302  ARHGAP322  ARHGAP332  ARHGAP312  
    1 SIMAP similar gene for RALBP1 using alignment to 3 protein entries:     RBP1_HUMAN (see all proteins):
    ARHGAP9

    RALBP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RALBP1
    PGOHUM00000240816 PGOHUM00000238278


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RALBP1 (see all 1322)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs620861131,2
    F--9473537(+) TATAGG/AATAGT 1 -- us2k12Minor allele frequency- A:0.13NA 122
    rs1119101191,2
    C,F--9473671(+) TGCTGT/ACCCTC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1847458171,2
    --9473681(+) CTAAAC/TTCCCA 1 -- us2k10--------
    rs1464800261,2
    --9473695(+) CTCTAA/GGGTTT 1 -- us2k10--------
    rs116605511,2
    H--9473781(+) TACAGA/TTTACT 1 -- us2k10--------
    rs1144820901,2
    F--9473791(+) TGGAAG/CCCTCA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs21203181,2
    C,F,O,H--9473880(-) CATTTA/GAGCCA 1 -- us2k116Minor allele frequency- G:0.19NS EA NA WA CSA 1974
    rs1411488621,2
    --9473883(+) CTTAAA/GTGGAA 1 -- us2k10--------
    rs99495851,2
    C,F--9474035(+) CTCCAA/CATGAA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1894661881,2
    --9474180(+) CCTCTA/GCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALBP1 (9475007 - 9538114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RALBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833585CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RALBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for RALBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605801    OMIM disorders: --

    12 diseases for RALBP1:    
    About MalaCards
    kidney cancer    lung cancer    vascular disease    atherosclerosis
    prostate cancer    prostatitis    pancreatic cancer    pancreatitis
    hepatocellular carcinoma    endotheliitis    leukemia    malaria


    RALBP1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for RALBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 53.6 14 16611992 (2), 14668343 (2), 18724939 (1), 19910467 (1) (see all 12)
    nsclc 42.5 31 16579994 (6), 12527936 (3), 15705900 (3), 15950949 (1) (see all 8)
    tumors 33.6 21 19632771 (3), 16611992 (2), 18724939 (1), 19910467 (1) (see all 13)
    cancer 29.1 29 20097178 (3), 18570872 (2), 15386349 (2), 15707977 (1) (see all 13)
    cancer lung 21.1 10 15950949 (3), 12527936 (2), 15705900 (2), 16087181 (1) (see all 6)
    small cell lung cancer 18 3 15950949 (1), 16087181 (1), 16579994 (1)
    leukemia 0 2 11522795 (1), 19417134 (1)
    prostate cancer 0 1 20097178 (1)

    Genetic Association Database (GAD): RALBP1
    Human Genome Epidemiology (HuGE) Navigator: RALBP1 (1 document)

    Export disorders for RALBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RALBP1 gene, integrated from 10 sources (see all 173):
    (articles sorted by number of sources associating them with RALBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PubMed id 7673236)1, 2, 3, 9 Jullien-Flores V.... Camonis J.H. (J. Biol. Chem. 1995)
    2. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PubMed id 10924126)1, 2, 9 Awasthi S.... Awasthi Y.C. (Biochemistry 2000)
    3. RLIP76 is the major ATP-dependent transporter of glutathione- conjugates and doxorubicin in human erythrocytes. (PubMed id 11437348)1, 2, 9 Sharma R.... Awasthi Y.C. (Arch. Biochem. Biophys. 2001)
    4. The association between polymorphisms in RLIP76 and drug response in epilepsy. (PubMed id 18086001)1, 4, 9 Leschziner G.D....Pirmohamed M. (Pharmacogenomics 2007)
    5. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 9 Zhang H.... Min W. (J. Biol. Chem. 2004)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)1, 2 Rosse C.... Camonis J. (J. Biol. Chem. 2003)
    9. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. (PubMed id 9422736)1, 2 Ikeda M.... Kikuchi A. (J. Biol. Chem. 1998)
    10. Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes. (PubMed id 11732624)1, 9 Singhal S.S....Awasthi S. (Acta Biochim. Pol. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10928 HGNC: 9841 AceView: RALBP1 Ensembl:ENSG00000017797 euGenes: HUgn10928
    ECgene: RALBP1 Kegg: 10928 H-InvDB: RALBP1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RALBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RALBP1 gene:
    Search GeneIP for patents involving RALBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Mono- and Polyclonal Antibodies for the study of RALBP1
     EMD Millipore Kits and Assays for the Analysis of RALBP1
     EMD Millipore Purified and/or Recombinant RALBP1 Protein
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RALBP1   OriGene RNAi products in human, mouse, rat for RALBP1  
     OriGene qPCR primer pairs and template standards for RALBP1   OriGene Protein Over-expression Lysate for RALBP1  
     OriGene MassSpec something-or-other for RALBP1   OriGene clones in human, mouse for RALBP1  
     OriGene qSTAR qPCR primer pairs in human, mouse for RALBP1   OriGene Purified Protein for RALBP1  
     OriGene ORF clones in mouse, rat for RALBP1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RALBP1   OriGene Custom Protein Services for RALBP1  

     
     
     Block miRNA regulation of human, mouse, rat RALBP1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RALBP1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALBP1 Predesigned siRNA for gene silencing in human, mouse, rat RALBP1
     QuantiFast Probe-based Assays in human, mouse, rat RALBP1 QuantiTect SYBR Green Assays in human, mouse, rat RALBP1
     Custom PCR Arrays for RALBP1 Search Chromatin IP Primers for RALBP1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RALBP1  GeneGlobe Interaction Network for RALBP1
     Regulatory tfbs in RALBP1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RALBP1 GenScript cDNA clones with any tag delivered in your preferred vector for RALBP1
     GenScript Custom Assay Services for RALBP1 GenScript Custom overexpressing Cell Line Services for RALBP1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RALBP1 

     Search Tocris compounds for RALBP1 (RBP1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for RALBP1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RALBP1 antibodies
     RALBP1 proteins
     RALBP1 lysates
     Antibodies for RALBP1
     See all of Abcam's Antibodies, Kits and Proteins for RALBP1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RALBP1
     Antibodies for RALBP1
     ELISAs for RALBP1
     CLIAs for RALBP1



     Browse ESI BIO Cell Lines and PureStem Progenitors for RALBP1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALBP1
     SwitchGear 3'UTR luciferase reporter plasmids for RALBP1
     SwitchGear Promoter luciferase reporter plasmids for RALBP1
     ThermoFisher Antibody for RALBP1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALBP1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALBP1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RALBP1
     LSBio Antibodies in human, mouse, rat for RALBP1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RALBP1 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4