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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RALBP1 Gene

protein-coding   GIFtS: 65
GCID: GC18P009465

RalA Binding Protein 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RalA Binding Protein 11 2     RLIP12 3
RLIP762 3 5     DNP-SG ATPase2 3
Dinitrophenyl S-Glutathione ATPase2 3     RIP12
Ral-Interacting Protein 12 3     RalA-Binding Protein 12
76 KDa Ral-Interacting Protein2 3     RalBP13

External Ids:    HGNC: 98411   Entrez Gene: 109282   Ensembl: ENSG000000177977   OMIM: 6058015   UniProtKB: Q153113   

Export aliases for RALBP1 gene to outside databases

Previous GC identifer: GC18P009629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RALBP1 Gene:
RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein
RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms,
which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is
activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 (PubMed 12888294)).(supplied by OMIM, Nov 2010)

GeneCards Summary for RALBP1 Gene: 
RALBP1 (ralA binding protein 1) is a protein-coding gene. Diseases associated with RALBP1 include kidney cancer, and lung cancer, and among its related super-pathways are Signaling by Rho GTPases and Doxorubicin Pathway (Cancer Cell), Pharmacodynamics. GO annotations related to this gene include Rac GTPase binding and GTPase activator activity.

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates
ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major
ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze
transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and
also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin

Gene Wiki entry for RALBP1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RALBP1 gene promoter:
         AREB6   Sp1   p53   AP-2beta   AP-2gamma   AP-2alpha   Pax-4a   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRALBP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RALBP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.22

RALBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALBP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009465:  view genomic region     (about GC identifiers)

Start:
9,475,007 bp from pter      End:
9,538,114 bp from pter
Size:
63,108 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311 (See protein sequence)
Recommended Name: RalA-binding protein 1  
Size: 655 amino acids; 76063 Da
Subunit: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this
does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and
CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis
Subcellular location: Membrane; Peripheral membrane protein
2 PDB 3D structures from and Proteopedia for RALBP1:
2KWH (3D)        2KWI (3D)    
Secondary accessions: D3DUI0

Explore the universe of human proteins at neXtProt for RALBP1: NX_Q15311

Explore proteomics data for RALBP1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15311

  • RALBP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RALBP1 Protein Expression
    REFSEQ proteins: NP_006779.1  
    ENSEMBL proteins: 
     ENSP00000019317   ENSP00000463693   ENSP00000372924   ENSP00000411556   ENSP00000462549  
    Reactome Protein details: Q15311
    Human Recombinant Protein Products for RALBP1: 
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    Novus Biologicals RALBP1 Protein
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    Cloud-Clone Corp. Proteins for RALBP1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA10924126

    RALBP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR008936 Rho_GTPase_activation_prot
     IPR000198 RhoGAP_dom

    Graphical View of Domain Structure for InterPro Entry Q15311

    ProtoNet protein and cluster: Q15311

    1 Blocks protein domain: IPB000198 RhoGAP domain

    UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
    Similarity: Contains 1 Rho-GAP domain


    RALBP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBP1_HUMAN, Q15311
    Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates
    ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major
    ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze
    transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon.
    Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and
    also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity IDA7673236
    GO:0005515protein binding IPI17703191
    GO:0016887ATPase activity IDA10924126
    GO:0017160Ral GTPase binding IPI7673236
    GO:0030675Rac GTPase activator activity IDA7673236
         
    RALBP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for RALBP1:
     Big cells  Increased G2M DNA content 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ralbp1):
     behavior/neurological  cellular  integument  mortality/aging 

    RALBP1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RALBP1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALBP1 
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    SwitchGear 3'UTR luciferase reporter plasmidRALBP1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RALBP1 About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    2Doxorubicin Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics0.43
    Doxorubicin Pathway, Pharmacokinetics0.43
    3G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88
    4GPCR Pathway
    Ras Pathway0.73
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 EMD Millipore Pathways for RALBP1
        G-protein signaling Regulation of CDC42 activity
    Cytoskeleton remodeling RalB regulation pathway
    Cytoskeleton remodeling RalA regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases
    G-protein signaling Regulation of RAC1 activity

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RALBP1
        FGF Pathway
    Molecular Mechanisms of Cancer
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for RALBP1
        Cytoskeletal Signaling

    5 GeneGo (Thomson Reuters) Pathways for RALBP1
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Cross-talk between Ras-family GTPases
    Cytoskeleton remodeling RalB regulation pathway
    G-protein signaling Regulation of CDC42 activity
    Cytoskeleton remodeling RalA regulation pathway

    4 BioSystems Pathways for RALBP1
        EGFR1 Signaling Pathway
    RalA downstream regulated genes
    Regulation of CDC42 activity
    Regulation of RAC1 activity


    3        Reactome Pathways for RALBP1
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle

    4 PharmGKB Pathways for RALBP1
        Carbamazepine Pathway, Pharmacokinetics
    Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
    Doxorubicin Pathway, Pharmacokinetics
    Vinka Alkaloid Pathway, Pharmacokinetics

    2         Kegg Pathways  (Kegg details for RALBP1):
        Pathways in cancer
    Pancreatic cancer


    RALBP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RALBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for RALBP1 (Q153112, 3 ENSP000000193174) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAX1BP1Q86VP12, 3, ENSP000003796124MINT-6505297 MINT-5226536 MINT-6505280 I2D: score=1 STRING: ENSP00000379612
    CCL20P785562, 3, ENSP000003516714MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000351671
    RALBP112342, 3, ENSP000002725194MINT-68413 I2D: score=7 STRING: ENSP00000272519
    ENSG00000228321P013753, ENSP000003928584I2D: score=1 STRING: ENSP00000392858
    ENSG00000204490P013753I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006200ATP catabolic process IDA10924126
    GO:0006810transport IDA10924126
    GO:0006935chemotaxis TAS10848592
    GO:0007165signal transduction TAS7673236
    GO:0007264small GTPase mediated signal transduction TAS--

    RALBP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RALBP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for RALBP1 (RBP1)

    2 HMDB Compounds for RALBP1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Glutathione5-L-Glutamyl-L-cysteinylglycine (see all 32)70-18-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    10/13 Novoseek inferred chemical compound relationships for RALBP1 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    s-(2,4-dinitrophenyl)glutathione 78.4 2 2143605 (1), 12545192 (1)
    4-hydroxynonenal 71.4 23 12527936 (3), 12422239 (2), 11522795 (2), 15950949 (1) (see all 9)
    doxorubicin 60.6 71 11437348 (5), 12527936 (4), 10924126 (4), 12545192 (4) (see all 16)
    8-azido-atp 59.3 1 9548754 (1)
    atp 32.5 31 12422239 (4), 7907606 (4), 11300797 (3), 15386349 (3) (see all 9)
    colchicine 32.4 1 10079207 (1)
    vinorelbine 25.8 7 15705900 (5)
    daunorubicin 19.2 3 11732624 (1)
    vinblastine 15.3 1 15705900 (1)
    threonine 15 2 18473820 (1), 17047155 (1)

    Search CenterWatch for drugs/clinical trials and news about RALBP1 / RBP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RALBP1 gene: 
    NM_006788.3  

    Unigene Cluster for RALBP1:

    RalA binding protein 1
    Hs.528993  [show with all ESTs]
    Unigene Representative Sequence: NM_006788
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000019317(uc002kob.3) ENST00000585015 ENST00000383432(uc002koc.3)
    ENST00000458039 ENST00000577221
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    Additional mRNA sequence: 

    AB209924.1 AK300845.1 AY517554.1 BC013126.1 L42542.1 

    13 DOTS entries:

    DT.92438991  DT.447437  DT.121085537  DT.95347147  DT.99985745  DT.100813889  DT.100813892  DT.92438996 
    DT.95106068  DT.101983390  DT.75143769  DT.92439007  DT.121085541 

    24/300 AceView cDNA sequences (see all 300):

    BX282029 CA430622 Z41618 BU150329 AW016627 BU194901 CF125335 BX282361 
    BQ086280 BU631590 AI127555 CD365287 AI279667 AA085990 AW025252 AI246142 
    CA422971 AI318427 BQ674032 BU729728 BM725485 AA720512 CA430233 AI184819 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                                                                          
    SP2:        -     -     -                                                                     
    SP3:                          -                                                               
    SP4:                    -     -                                                               


    ECgene alternative splicing isoforms for RALBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RALBP1 expression in normal human tissues (normalized intensities)      RALBP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RALBP1 Expression
    About this image


    RALBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Blood (Hematopoietic System)
             leukocytes   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See RALBP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RALBP1

    SOURCE GeneReport for Unigene cluster: Hs.528993

    UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311
    Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RALBP1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralbp11 , 5 ralA binding protein 11, 5 88.32(n)1
    92.75(a)1
      17 (35.26 cM)5
    197651  NM_001198949.11  NP_001185878.11 
     658484335 
    chicken
    (Gallus gallus)
    Aves RALBP11 ralA binding protein 1 83.39(n)
    93.49(a)
      429466  NM_001031575.1  NP_001026746.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALBP16
    Uncharacterized protein
    89(a)
    1 ↔ 1
    GL343319.1(580199-614934)
    African clawed frog
    (Xenopus laevis)
    Amphibia rlip1-A-prov2 RalB-binding protein 77.45(n)    AJ304845.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ralbp11 ralA binding protein 1 71.06(n)
    77.83(a)
      404612  NM_207080.1  NP_996963.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rlip1 , 3 RAL GTPase activator3
    Ral interacting protein1
    34(a)3
    48.25(n)1
    38.67(a)1
      93B43
    424841  NM_142676.31  NP_650933.21 
    worm
    (Caenorhabditis elegans)
    Secernentea rlbp-11 Protein RLBP-1 41.89(n)
    30.27(a)
      172530  NM_059739.2  NP_492140.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RGA26
    RGA16
    GTPase-activating protein for the polarity-establi...
    GTPase-activating protein for the polarity-establi...
    6(a)
    5(a)
    many ↔ many
    many ↔ many
    IV(1230167-1233196)
    XV(561170-564193)


    ENSEMBL Gene Tree for RALBP1 (if available)
    TreeFam Gene Tree for RALBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RALBP1 gene
    1 SIMAP similar gene for RALBP1 using alignment to 3 protein entries:     RBP1_HUMAN (see all proteins):
    ARHGAP9

    RALBP1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RALBP1
    PGOHUM00000240816 PGOHUM00000238278


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1322 SNPs in RALBP1 are shown (see all 1322)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs620861131,2
    F--9473537(+) TATAGG/AATAGT 1 -- us2k12Minor allele frequency- A:0.13NA 122
    rs1119101191,2
    C,F--9473671(+) TGCTGT/ACCCTC 1 -- us2k12Minor allele frequency- A:0.04CSA WA 120
    rs1847458171,2
    --9473681(+) CTAAAC/TTCCCA 1 -- us2k10--------
    rs1464800261,2
    --9473695(+) CTCTAA/GGGTTT 1 -- us2k10--------
    rs116605511,2
    H--9473781(+) TACAGA/TTTACT 1 -- us2k10--------
    rs1144820901,2
    F--9473791(+) TGGAAG/CCCTCA 1 -- us2k11Minor allele frequency- C:0.01WA 118
    rs21203181,2
    C,F,O,H--9473880(-) CATTTA/GAGCCA 1 -- us2k116Minor allele frequency- G:0.19NS EA NA WA CSA 1974
    rs1411488621,2
    --9473883(+) CTTAAA/GTGGAA 1 -- us2k10--------
    rs99495851,2
    C,F--9474035(+) CTCCAA/CATGAA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs1894661881,2
    --9474180(+) CCTCTA/GCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALBP1 (9475007 - 9538114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for RALBP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833585CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605801    OMIM disorders: --

    13 diseases for RALBP1:    About MalaCards
    kidney cancer    lung cancer    vascular disease    non-small cell lung carcinoma
    atherosclerosis    glioblastoma    prostate cancer    pancreatic cancer
    colon cancer    prostatitis    pancreatitis    hepatocellular carcinoma
    endotheliitis


    RALBP1 for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for RALBP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 53.6 14 16611992 (2), 14668343 (2), 18724939 (1), 19910467 (1) (see all 12)
    nsclc 42.5 31 16579994 (6), 12527936 (3), 15705900 (3), 15950949 (1) (see all 8)
    tumors 33.6 21 19632771 (3), 16611992 (2), 18724939 (1), 19910467 (1) (see all 13)
    cancer 29.1 29 20097178 (3), 18570872 (2), 15386349 (2), 15707977 (1) (see all 13)
    cancer lung 21.1 10 15950949 (3), 12527936 (2), 15705900 (2), 16087181 (1) (see all 6)
    small cell lung cancer 18 3 15950949 (1), 16087181 (1), 16579994 (1)
    leukemia 0 2 11522795 (1), 19417134 (1)
    prostate cancer 0 1 20097178 (1)

    Genetic Association Database (GAD): RALBP1
    Human Genome Epidemiology (HuGE) Navigator: RALBP1 (1 document)

    Export disorders for RALBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RALBP1 gene, integrated from 9 sources (see all 169):
    (articles sorted by number of sources associating them with RALBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PubMed id 7673236)1, 2, 3, 9 Jullien-Flores V.... Camonis J.H. (1995)
    2. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PubMed id 10924126)1, 2, 9 Awasthi S.... Awasthi Y.C. (2000)
    3. RLIP76 is the major ATP-dependent transporter of glutathione- conjugates and doxorubicin in human erythrocytes. (PubMed id 11437348)1, 2, 9 Sharma R.... Awasthi Y.C. (2001)
    4. The association between polymorphisms in RLIP76 and drug response in epilepsy. (PubMed id 18086001)1, 4, 9 Leschziner G.D....Pirmohamed M. (2007)
    5. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 9 Zhang H.... Min W. (2004)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)1, 2 Rosse C.... Camonis J. (2003)
    9. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. (PubMed id 9422736)1, 2 Ikeda M.... Kikuchi A. (1998)
    10. Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes. (PubMed id 11732624)1, 9 Singhal S.S....Awasthi S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10928 HGNC: 9841 AceView: RALBP1 Ensembl:ENSG00000017797 euGenes: HUgn10928
    ECgene: RALBP1 Kegg: 10928 H-InvDB: RALBP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RALBP1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALBP1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RALBP1 gene:
    Search GeneIP for patents involving RALBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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