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Aliases for RALBP1 Gene

Aliases for RALBP1 Gene

  • RalA Binding Protein 1 2 3
  • RLIP76 3 4 6
  • Dinitrophenyl S-Glutathione ATPase 3 4
  • 76 KDa Ral-Interacting Protein 3 4
  • Ral-Interacting Protein 1 3 4
  • DNP-SG ATPase 3 4
  • RLIP1 3 4
  • RalA-Binding Protein 1 3
  • RalBP1 4
  • RIP1 3

External Ids for RALBP1 Gene

Summaries for RALBP1 Gene

Entrez Gene Summary for RALBP1 Gene

  • RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RALBP1 Gene

RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for RALBP1 Gene

  • Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Wiki entry for RALBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALBP1 Gene

Genomics for RALBP1 Gene

Genomic Location for RALBP1 Gene

Start:
9,473,436 bp from pter
End:
9,538,116 bp from pter
Size:
64,681 bases
Orientation:
Plus strand

Genomic View for RALBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALBP1 Gene

Regulatory Elements for RALBP1 Gene

Proteins for RALBP1 Gene

  • Protein details for RALBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15311-RBP1_HUMAN
    Recommended name:
    RalA-binding protein 1
    Protein Accession:
    Q15311
    Secondary Accessions:
    • D3DUI0

    Protein attributes for RALBP1 Gene

    Size:
    655 amino acids
    Molecular mass:
    76063 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.

    Three dimensional structures from OCA and Proteopedia for RALBP1 Gene

neXtProt entry for RALBP1 Gene

Proteomics data for RALBP1 Gene at MOPED

Post-translational modifications for RALBP1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys161

Other Protein References for RALBP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RALBP1 Gene

Domains for RALBP1 Gene

Protein Domains for RALBP1 Gene

UniProtKB/Swiss-Prot:

RBP1_HUMAN
Domain:
  • Contains 1 Rho-GAP domain.:
    • Q15311
genes like me logo Genes that share domains with RALBP1: view

No data available for Gene Families for RALBP1 Gene

Function for RALBP1 Gene

Molecular function for RALBP1 Gene

UniProtKB/Swiss-Prot Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Ontology (GO) - Molecular Function for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 7673236
GO:0005515 protein binding IPI 17703191
GO:0016887 ATPase activity IDA 10924126
GO:0017160 Ral GTPase binding IPI 24056301
GO:0043492 ATPase activity, coupled to movement of substances IDA 11437348
genes like me logo Genes that share ontologies with RALBP1: view
genes like me logo Genes that share phenotypes with RALBP1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RALBP1 Gene

Localization for RALBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALBP1 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALBP1 Gene COMPARTMENTS Subcellular localization image for RALBP1 gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 10924126
genes like me logo Genes that share ontologies with RALBP1: view

Pathways for RALBP1 Gene

genes like me logo Genes that share pathways with RALBP1: view

Gene Ontology (GO) - Biological Process for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006810 transport IDA 10924126
GO:0006935 chemotaxis TAS 10848592
GO:0007165 signal transduction TAS 7673236
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RALBP1: view

Compounds for RALBP1 Gene

(2) HMDB Compounds for RALBP1 Gene

Compound Synonyms Cas Number PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8
Guanosine triphosphate
  • 5'-GTP
86-01-1

(13) Novoseek inferred chemical compound relationships for RALBP1 Gene

Compound -log(P) Hits PubMed IDs
s-(2,4-dinitrophenyl)glutathione 78.4 2
4-hydroxynonenal 71.4 13
doxorubicin 60.6 40
8-azido-atp 59.3 1
atp 32.5 24
genes like me logo Genes that share compounds with RALBP1: view

Transcripts for RALBP1 Gene

Unigene Clusters for RALBP1 Gene

RalA binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for RALBP1 Gene

GeneLoc Exon Structure for
RALBP1
ECgene alternative splicing isoforms for
RALBP1

Expression for RALBP1 Gene

mRNA expression in normal human tissues for RALBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALBP1 Gene

SOURCE GeneReport for Unigene cluster for RALBP1 Gene Hs.528993

mRNA Expression by UniProt/SwissProt for RALBP1 Gene

Q15311-RBP1_HUMAN
Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
genes like me logo Genes that share expressions with RALBP1: view

Orthologs for RALBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RALBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALBP1 36
  • 99.59 (n)
  • 99.69 (a)
RALBP1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALBP1 36
  • 85.62 (n)
  • 93.39 (a)
RALBP1 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALBP1 36
  • 92.05 (n)
  • 95.36 (a)
RALBP1 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralbp1 36
  • 88.32 (n)
  • 92.75 (a)
Ralbp1 16
Ralbp1 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALBP1 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ralbp1 36
  • 87.29 (n)
  • 92.97 (a)
chicken
(Gallus gallus)
Aves RALBP1 36
  • 83.39 (n)
  • 93.49 (a)
RALBP1 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALBP1 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rlip1-A-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ralbp1 36
  • 77.86 (n)
  • 86.72 (a)
Str.11420 36
zebrafish
(Danio rerio)
Actinopterygii ralbp1 36
  • 70.7 (n)
  • 76.86 (a)
ralbp1 37
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rlip 37
  • 24 (a)
OneToOne
Rlip 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea rlbp-1 37
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 37
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToOne
Species with no ortholog for RALBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALBP1 Gene

ENSEMBL:
Gene Tree for RALBP1 (if available)
TreeFam:
Gene Tree for RALBP1 (if available)

Paralogs for RALBP1 Gene

Paralogs for RALBP1 Gene

Selected SIMAP similar genes for RALBP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RALBP1 Gene

genes like me logo Genes that share paralogs with RALBP1: view

Variants for RALBP1 Gene

Sequence variations from dbSNP and Humsavar for RALBP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs3321 -- 9,536,652(+) CTCAC(C/T)GCGGG utr-variant-3-prime
rs3322 -- 9,536,693(+) CAAAG(A/G)TAGTC utr-variant-3-prime
rs10898 -- 9,536,251(+) AAAAA(C/T)CGTCT utr-variant-3-prime
rs12680 -- 9,537,837(+) AGGGA(C/G)CCTGT utr-variant-3-prime
rs14336 -- 9,536,317(+) ACCAC(A/C)CCAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RALBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833585 CNV Gain+Loss 17160897

Relevant External Links for RALBP1 Gene

HapMap Linkage Disequilibrium report
RALBP1

Disorders for RALBP1 Gene

(8) Novoseek inferred disease relationships for RALBP1 Gene

Disease -log(P) Hits PubMed IDs
necrosis 53.6 14
nsclc 42.5 17
tumors 33.6 16
cancer 29.1 17
cancer lung 21.1 10

Relevant External Links for RALBP1

Genetic Association Database (GAD)
RALBP1
Human Genome Epidemiology (HuGE) Navigator
RALBP1
genes like me logo Genes that share disorders with RALBP1: view

No data available for UniProtKB/Swiss-Prot for RALBP1 Gene

Publications for RALBP1 Gene

  1. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PMID: 7673236) Jullien-Flores V. … Camonis J.H. (J. Biol. Chem. 1995) 2 3 4 23
  2. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PMID: 10924126) Awasthi S. … Awasthi Y.C. (Biochemistry 2000) 3 4 23
  3. RLIP76 is the major ATP-dependent transporter of glutathione- conjugates and doxorubicin in human erythrocytes. (PMID: 11437348) Sharma R. … Awasthi Y.C. (Arch. Biochem. Biophys. 2001) 3 4 23
  4. The association between polymorphisms in RLIP76 and drug response in epilepsy. (PMID: 18086001) Leschziner G.D. … Pirmohamed M. (Pharmacogenomics 2007) 3 23 49
  5. Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. (PMID: 12527936) Singhal S.S. … Awasthi S. (Int. J. Oncol. 2003) 3 23

Products for RALBP1 Gene

Sources for RALBP1 Gene

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