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Aliases for RALBP1 Gene

Aliases for RALBP1 Gene

  • RalA Binding Protein 1 2 3 5
  • Dinitrophenyl S-Glutathione ATPase 3 4
  • 76 KDa Ral-Interacting Protein 3 4
  • Ral-Interacting Protein 1 3 4
  • DNP-SG ATPase 3 4
  • RLIP76 3 4
  • RLIP1 3 4
  • RalBP1 4
  • RIP1 3

External Ids for RALBP1 Gene

Previous GeneCards Identifiers for RALBP1 Gene

  • GC18P009629

Summaries for RALBP1 Gene

Entrez Gene Summary for RALBP1 Gene

  • RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RALBP1 Gene

RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include lung cancer. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is ARHGAP31.

UniProtKB/Swiss-Prot for RALBP1 Gene

  • Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Wiki entry for RALBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALBP1 Gene

Genomics for RALBP1 Gene

Regulatory Elements for RALBP1 Gene

Promoters for RALBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RALBP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RALBP1 Gene

Chromosome:
18
Start:
9,475,009 bp from pter
End:
9,538,116 bp from pter
Size:
63,108 bases
Orientation:
Plus strand

Genomic View for RALBP1 Gene

Genes around RALBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALBP1 Gene

Proteins for RALBP1 Gene

  • Protein details for RALBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15311-RBP1_HUMAN
    Recommended name:
    RalA-binding protein 1
    Protein Accession:
    Q15311
    Secondary Accessions:
    • D3DUI0

    Protein attributes for RALBP1 Gene

    Size:
    655 amino acids
    Molecular mass:
    76063 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.

    Three dimensional structures from OCA and Proteopedia for RALBP1 Gene

neXtProt entry for RALBP1 Gene

Proteomics data for RALBP1 Gene at MOPED

Post-translational modifications for RALBP1 Gene

  • Ubiquitination at Lys 161
  • Modification sites at PhosphoSitePlus

Other Protein References for RALBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RALBP1 (RALBP1)

No data available for DME Specific Peptides for RALBP1 Gene

Domains & Families for RALBP1 Gene

Protein Domains for RALBP1 Gene

Suggested Antigen Peptide Sequences for RALBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15311

UniProtKB/Swiss-Prot:

RBP1_HUMAN :
  • Contains 1 Rho-GAP domain.
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with RALBP1: view

No data available for Gene Families for RALBP1 Gene

Function for RALBP1 Gene

Molecular function for RALBP1 Gene

UniProtKB/Swiss-Prot Function:
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Ontology (GO) - Molecular Function for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 9422736
GO:0048365 Rac GTPase binding IPI 7673236
genes like me logo Genes that share ontologies with RALBP1: view
genes like me logo Genes that share phenotypes with RALBP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RALBP1

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RALBP1 Gene

Localization for RALBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALBP1 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALBP1 Gene COMPARTMENTS Subcellular localization image for RALBP1 gene
Compartment Confidence
cytosol 5
nucleus 3
endosome 2
vacuole 2

No data available for Gene Ontology (GO) - Cellular Components for RALBP1 Gene

Pathways & Interactions for RALBP1 Gene

genes like me logo Genes that share pathways with RALBP1: view

Gene Ontology (GO) - Biological Process for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IDA 10924126
GO:0006935 chemotaxis TAS 10848592
GO:0007165 signal transduction IEA,TAS 7673236
GO:0007264 small GTPase mediated signal transduction TAS,IPI 7673236
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with RALBP1: view

No data available for SIGNOR curated interactions for RALBP1 Gene

Drugs & Compounds for RALBP1 Gene

(16) Drugs for RALBP1 Gene - From: Novoseek, FDA Approved Drugs, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Transporter, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1582
Carbamazepine Approved, Investigational Pharma Transporter, substrate 118
Sorafenib Approved, Investigational Pharma Transporter, substrate Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 671
Vincristine Approved, Investigational Pharma Transporter, substrate Microtubule disrupter,antitumor agent 863
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1582

(5) Additional Compounds for RALBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALBP1: view

Transcripts for RALBP1 Gene

Unigene Clusters for RALBP1 Gene

RalA binding protein 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for RALBP1 Gene

GeneLoc Exon Structure for
RALBP1
ECgene alternative splicing isoforms for
RALBP1

Expression for RALBP1 Gene

mRNA expression in normal human tissues for RALBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RALBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALBP1 Gene



SOURCE GeneReport for Unigene cluster for RALBP1 Gene Hs.528993

mRNA Expression by UniProt/SwissProt for RALBP1 Gene

Q15311-RBP1_HUMAN
Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.
genes like me logo Genes that share expression patterns with RALBP1: view

Protein tissue co-expression partners for RALBP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RALBP1 Gene

Orthologs for RALBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RALBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RALBP1 35
  • 85.62 (n)
  • 93.39 (a)
RALBP1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALBP1 35
  • 92.05 (n)
  • 95.36 (a)
RALBP1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ralbp1 35
  • 88.32 (n)
  • 92.75 (a)
Ralbp1 16
Ralbp1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RALBP1 35
  • 99.59 (n)
  • 99.69 (a)
RALBP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralbp1 35
  • 87.29 (n)
  • 92.97 (a)
oppossum
(Monodelphis domestica)
Mammalia RALBP1 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves RALBP1 35
  • 83.39 (n)
  • 93.49 (a)
RALBP1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALBP1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralbp1 35
  • 77.86 (n)
  • 86.72 (a)
Str.11420 35
African clawed frog
(Xenopus laevis)
Amphibia rlip1-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii ralbp1 35
  • 70.7 (n)
  • 76.86 (a)
ralbp1 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rlip 37
  • 34 (a)
Rlip 36
  • 24 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rlbp-1 36
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for RALBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALBP1 Gene

ENSEMBL:
Gene Tree for RALBP1 (if available)
TreeFam:
Gene Tree for RALBP1 (if available)

Paralogs for RALBP1 Gene

Paralogs for RALBP1 Gene

(1) SIMAP similar genes for RALBP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RALBP1 Gene

genes like me logo Genes that share paralogs with RALBP1: view

Variants for RALBP1 Gene

Sequence variations from dbSNP and Humsavar for RALBP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs35867116 - 9,535,819(-) GGACG(A/G)CACCC reference, missense
rs3321 -- 9,536,652(+) CTCAC(C/T)GCGGG utr-variant-3-prime
rs3322 -- 9,536,693(+) CAAAG(A/G)TAGTC utr-variant-3-prime
rs10898 -- 9,536,251(+) AAAAA(C/T)CGTCT utr-variant-3-prime
rs12680 -- 9,537,837(+) AGGGA(C/G)CCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RALBP1 Gene

Variant ID Type Subtype PubMed ID
nsv833585 CNV Gain+Loss 17160897

Variation tolerance for RALBP1 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALBP1 Gene

HapMap Linkage Disequilibrium report
RALBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALBP1 Gene

Disorders for RALBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALBP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RALBP1

Genetic Association Database (GAD)
RALBP1
Human Genome Epidemiology (HuGE) Navigator
RALBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALBP1
genes like me logo Genes that share disorders with RALBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALBP1 Gene

Publications for RALBP1 Gene

  1. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PMID: 7673236) Jullien-Flores V. … Camonis J.H. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. (PMID: 19626587) Singhal S.S. … Awasthi S. (Int. J. Cancer 2010) 3 23 25
  3. Increased expression of cdc2 inhibits transport function of RLIP76 and promotes apoptosis. (PMID: 19375851) Singhal S.S. … Awasthi S. (Cancer Lett. 2009) 3 23
  4. RLIP76: a target for kidney cancer therapy. (PMID: 19417134) Singhal S.S. … Awasthi S. (Cancer Res. 2009) 3 23
  5. Physiological and pharmacological significance of glutathione-conjugate transport. (PMID: 20183533) Awasthi Y.C. … Sharma R. (J Toxicol Environ Health B Crit Rev 2009) 3 23

Products for RALBP1 Gene

Sources for RALBP1 Gene

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