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Aliases for RALBP1 Gene

Aliases for RALBP1 Gene

  • RalA Binding Protein 1 2 3 5
  • Dinitrophenyl S-Glutathione ATPase 3 4
  • 76 KDa Ral-Interacting Protein 3 4
  • Ral-Interacting Protein 1 3 4
  • DNP-SG ATPase 3 4
  • RLIP76 3 4
  • RLIP1 3 4
  • RalA-Binding Protein 1 3
  • RalBP1 4
  • RIP1 3

External Ids for RALBP1 Gene

Previous GeneCards Identifiers for RALBP1 Gene

  • GC18P009629

Summaries for RALBP1 Gene

Entrez Gene Summary for RALBP1 Gene

  • RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RALBP1 Gene

RALBP1 (RalA Binding Protein 1) is a Protein Coding gene. Diseases associated with RALBP1 include Lung Cancer. Among its related pathways are Doxorubicin Pathway, Pharmacokinetics and Ras signaling pathway. GO annotations related to this gene include GTPase activator activity and Rac GTPase binding. An important paralog of this gene is ARHGAP32.

UniProtKB/Swiss-Prot for RALBP1 Gene

  • Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Wiki entry for RALBP1 Gene

Additional gene information for RALBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALBP1 Gene

Genomics for RALBP1 Gene

Regulatory Elements for RALBP1 Gene

Enhancers for RALBP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18H009506 0.8 ENCODE 30 +31.6 31589 0 PKNOX1 ZNF792 ZSCAN4 INSM2 FEZF1 ZNF384 ZIC2 GLIS2 ZNF239 PRDM10 RALBP1 ENSG00000266805 RNU2-27P
GH18H009493 1.4 FANTOM5 Ensembl ENCODE 14.7 +20.8 20773 3 HDAC1 ETV1 ZNF175 BMI1 CTBP1 GATA3 ELK1 RUNX3 IKZF2 TCF7L2 RALBP1 RAB31 ANKRD12 VAPA GC18P009504
GH18H009473 1.1 ENCODE 15.1 +1.0 1023 4 HDGF PKNOX1 FOXA2 ARNT SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ENSG00000273335 RALBP1 GC18P009504
GH18H009534 1.1 Ensembl ENCODE 14.7 +60.6 60563 2 ELF3 TBP FOXA2 MLX ARID4B DMAP1 THRB ZSCAN9 RARA MIXL1 RALBP1 PPP4R1 RNU2-27P ENSG00000266541
GH18H009449 0.7 ENCODE dbSUPER 21.4 -24.9 -24851 1 PKNOX1 ZNF7 RALBP1 GC18P009473 LOC105371980
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RALBP1 on UCSC Golden Path with GeneCards custom track

Promoters for RALBP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000100547 791 2401 HDGF PKNOX1 FOXA2 SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143

Genomic Location for RALBP1 Gene

Chromosome:
18
Start:
9,475,009 bp from pter
End:
9,538,116 bp from pter
Size:
63,108 bases
Orientation:
Plus strand

Genomic View for RALBP1 Gene

Genes around RALBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALBP1 Gene

Proteins for RALBP1 Gene

  • Protein details for RALBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15311-RBP1_HUMAN
    Recommended name:
    RalA-binding protein 1
    Protein Accession:
    Q15311
    Secondary Accessions:
    • D3DUI0

    Protein attributes for RALBP1 Gene

    Size:
    655 amino acids
    Molecular mass:
    76063 Da
    Quaternary structure:
    • Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.

    Three dimensional structures from OCA and Proteopedia for RALBP1 Gene

neXtProt entry for RALBP1 Gene

Post-translational modifications for RALBP1 Gene

  • Ubiquitination at Lys161
  • Modification sites at PhosphoSitePlus

Other Protein References for RALBP1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RALBP1 (RALBP1)

No data available for DME Specific Peptides for RALBP1 Gene

Domains & Families for RALBP1 Gene

Gene Families for RALBP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transporters

Protein Domains for RALBP1 Gene

Suggested Antigen Peptide Sequences for RALBP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RALBP1: view

No data available for UniProtKB/Swiss-Prot for RALBP1 Gene

Function for RALBP1 Gene

Molecular function for RALBP1 Gene

UniProtKB/Swiss-Prot Function:
Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.

Gene Ontology (GO) - Molecular Function for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity TAS --
GO:0005515 protein binding IPI 9422736
GO:0016887 ATPase activity IDA 10924126
GO:0017160 Ral GTPase binding IPI 7673236
GO:0022857 transmembrane transporter activity IDA 11437348
genes like me logo Genes that share ontologies with RALBP1: view
genes like me logo Genes that share phenotypes with RALBP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RALBP1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RALBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RALBP1 Gene

Localization for RALBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALBP1 Gene

Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALBP1 gene
Compartment Confidence
cytosol 5
nucleus 3
endosome 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA,IEA 10924126
genes like me logo Genes that share ontologies with RALBP1: view

Pathways & Interactions for RALBP1 Gene

genes like me logo Genes that share pathways with RALBP1: view

Gene Ontology (GO) - Biological Process for RALBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA,IDA 10924126
GO:0006897 endocytosis IBA --
GO:0006935 chemotaxis TAS 10848592
GO:0007165 signal transduction TAS 7673236
GO:0007264 small GTPase mediated signal transduction IPI 7673236
genes like me logo Genes that share ontologies with RALBP1: view

No data available for SIGNOR curated interactions for RALBP1 Gene

Drugs & Compounds for RALBP1 Gene

(17) Drugs for RALBP1 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxorubicin Approved, Investigational Pharma Transporter, substrate Topo II inhibitor,immunosuppresive antineoplastic antibiotic 1784
Carbamazepine Approved, Investigational Pharma Transporter, substrate 132
Sorafenib Approved, Investigational Pharma Transporter, substrate Raf kinases and tyrosine kinases inhibitor, RAF, VEGFR2, and PDGFR-beta inhibitors, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 708
Vincristine Approved, Investigational Pharma Transporter, substrate Microtubule disrupter,antitumor agent 954
Doxil Approved June 1999 Pharma DNA intercalator and TOPO II inhibitor, Topoisomerase 2 Inhibitors 1785

(4) Additional Compounds for RALBP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALBP1: view

Transcripts for RALBP1 Gene

Unigene Clusters for RALBP1 Gene

RalA binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RALBP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - -
SP3: -
SP4: - -

Relevant External Links for RALBP1 Gene

GeneLoc Exon Structure for
RALBP1
ECgene alternative splicing isoforms for
RALBP1

Expression for RALBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RALBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RALBP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.8) and Retina (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RALBP1 Gene



Protein tissue co-expression partners for RALBP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RALBP1 Gene:

RALBP1

SOURCE GeneReport for Unigene cluster for RALBP1 Gene:

Hs.528993

mRNA Expression by UniProt/SwissProt for RALBP1 Gene:

Q15311-RBP1_HUMAN
Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.

Evidence on tissue expression from TISSUES for RALBP1 Gene

  • Liver(4.4)
  • Nervous system(4.4)
  • Blood(4.3)
  • Bone marrow(4.2)
  • Kidney(2.2)
  • Lung(2.1)
  • Heart(2)
  • Intestine(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with RALBP1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALBP1 Gene

Orthologs for RALBP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RALBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALBP1 33 34
  • 99.59 (n)
dog
(Canis familiaris)
Mammalia RALBP1 33 34
  • 92.05 (n)
oppossum
(Monodelphis domestica)
Mammalia RALBP1 34
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 92 (a)
OneToMany
-- 34
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ralbp1 33 16 34
  • 88.32 (n)
rat
(Rattus norvegicus)
Mammalia Ralbp1 33
  • 87.29 (n)
cow
(Bos Taurus)
Mammalia RALBP1 33 34
  • 85.62 (n)
chicken
(Gallus gallus)
Aves RALBP1 33 34
  • 83.39 (n)
lizard
(Anolis carolinensis)
Reptilia RALBP1 34
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ralbp1 33
  • 77.86 (n)
Str.11420 33
African clawed frog
(Xenopus laevis)
Amphibia rlip1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii ralbp1 33 34
  • 70.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rlip 35 34
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea rlbp-1 34
  • 21 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RGD1 34
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 47 (a)
OneToOne
Species where no ortholog for RALBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALBP1 Gene

ENSEMBL:
Gene Tree for RALBP1 (if available)
TreeFam:
Gene Tree for RALBP1 (if available)

Paralogs for RALBP1 Gene

(1) SIMAP similar genes for RALBP1 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RALBP1 Gene

genes like me logo Genes that share paralogs with RALBP1: view

Variants for RALBP1 Gene

Sequence variations from dbSNP and Humsavar for RALBP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1000089842 -- 9,512,804(+) TACTC(C/G/T)AAGAT intron-variant
rs1000091799 -- 9,498,484(+) CTTTA(C/T)TTACT intron-variant
rs1000115058 -- 9,487,584(+) CTGCA(A/G)CCTCC intron-variant
rs1000146629 -- 9,529,070(+) AGAGA(A/G)AGTTC intron-variant
rs1000229096 -- 9,509,604(+) AAGGC(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALBP1 Gene

Variant ID Type Subtype PubMed ID
nsv1056407 CNV gain 25217958
nsv833585 CNV gain+loss 17160897
nsv962485 CNV duplication 23825009
nsv978599 CNV duplication 23825009

Variation tolerance for RALBP1 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALBP1 Gene

Disorders for RALBP1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALBP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RALBP1

Genetic Association Database (GAD)
RALBP1
Human Genome Epidemiology (HuGE) Navigator
RALBP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALBP1
genes like me logo Genes that share disorders with RALBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALBP1 Gene

Publications for RALBP1 Gene

  1. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PMID: 7673236) Jullien-Flores V … Camonis JH (The Journal of biological chemistry 1995) 2 3 4 22 60
  2. The association between polymorphisms in RLIP76 and drug response in epilepsy. (PMID: 18086001) Leschziner GD … Pirmohamed M (Pharmacogenomics 2007) 3 22 45 60
  3. RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. (PMID: 11437348) Sharma R … Awasthi YC (Archives of biochemistry and biophysics 2001) 3 4 22 60
  4. Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PMID: 10924126) Awasthi S … Awasthi YC (Biochemistry 2000) 3 4 22 60
  5. Rlip76 transports sunitinib and sorafenib and mediates drug resistance in kidney cancer. (PMID: 19626587) Singhal SS … Awasthi S (International journal of cancer 2010) 3 22 60

Products for RALBP1 Gene

Sources for RALBP1 Gene

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