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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RALBP1 Gene

protein-coding GIFtS: 65
GCID: GC18P009465

ralA binding protein 1

Explore 14 diseases affiliated with
RALBP1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RalA Binding Protein 1¹ ²		RLIP1² ³
RLIP76¹ ² ³ ⁵		DNP-SG ATPase² ³
RIP1¹ ²		RIP¹
Dinitrophenyl S-Glutathione ATPase² ³		RalA-Binding Protein 1²
Ral-Interacting Protein 1² ³		RalBP1³
76 KDa Ral-Interacting Protein² ³

External Ids:	HGNC: 9841¹	Entrez Gene: 10928²	Ensembl: ENSG00000017797⁷	OMIM: 605801⁵	UniProtKB: Q15311³

Export aliases for RALBP1 gene to outside databases

Previous GC identifer: GC18P009629

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RALBP1:

RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL

(see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift

from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS

(see HRAS; MIM 190020) (summary by Feig, 2003 (PubMed 12888294)).(supplied by OMIM, Nov 2010)

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311

Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent

transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent

transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of

glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a

scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to

switch off endocytosis, One of its substrates would be EPN1/Epsin

Gene Wiki entry for RALBP1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RALBP1 gene promoter:
AREB6 Sp1 p53 AP-2beta AP-2gamma AP-2alpha Pax-4a AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RALBP1 promoter sequence

Search SABiosciences Chromatin IP Primers for RALBP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALBP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3 Ensembl cytogenetic band: 18p11.22 HGNC cytogenetic band: 18p11.22

RALBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALBP1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P009465: view genomic region (about GC identifiers)

Start:	9,475,007 bp from pter	End:	9,538,114 bp from pter
Size:	63,108 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311 (See protein sequence)

Recommended Name: RalA-binding protein 1

Size: 655 amino acids; 76063 Da

Subunit: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does

not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDK1 during

mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis

Subcellular location: Membrane; Peripheral membrane protein

2 PDB 3D structures from and Proteopedia for RALBP1:

2KWH (3D)

2KWI (3D)

Secondary accessions: D3DUI0

Explore the universe of human proteins at neXtProt for RALBP1: NX_Q15311

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15311

RALBP1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006779.1

ENSEMBL proteins:

ENSP00000019317 ENSP00000463693 ENSP00000372924 ENSP00000411556 ENSP00000462549

Reactome Protein details: Q15311
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant RALBP1 Protein
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	Novus Biologicals RALBP1 Protein Novus Biologicals RALBP1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RALBP1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--
GO:0016020	membrane	IDA	11437348

RALBP1 for ontologies About GeneDecksing

RALBP1 Antibody Products:

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	Novus Biologicals RALBP1 Antibodies
	Abcam antibodies for RALBP1
	Uscn Antibodies for RALBP1
	ThermoFisher Antibody for RALBP1

Assay Products for RALBP1:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for RALBP1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for RALBP1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RALBP1 for domains About GeneDecksing

2 InterPro domains/families:

IPR008936 Rho_GTPase_activation_prot

IPR000198 RhoGAP_dom

Graphical View of Domain Structure for InterPro Entry Q15311

ProtoNet protein and cluster: Q15311

1 Blocks protein family: IPB000198 RhoGAP domain

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311

Similarity: Contains 1 Rho-GAP domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311

Function: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent

transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent

transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of

glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a

scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to

switch off endocytosis, One of its substrates would be EPN1/Epsin

miRNA Products:		OriGene 3'-UTR Clone: RALBP1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RALBP1
		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate RALBP1 (see all 69):
		hsa-miR-3194-5p hsa-miR-607 hsa-miR-3916 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-4293 hsa-miR-3148 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: RALBP1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RALBP1 (see all 7) OriGene shRNA RFP: RALBP1 OriGene siRNA: RALBP1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RALBP1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: RALBP1 (NM_006788)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RALBP1
		Search LifeMap BioReagents cell lines for RALBP1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALBP1

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IDA	7673236
GO:0005515	protein binding	IPI	9422736
GO:0016887	ATPase activity	IDA	10924126
GO:0017160	Ral GTPase binding	IPI	7673236
GO:0030675	Rac GTPase activator activity	IDA	7673236

RALBP1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for RALBP1:

Big cells

Increased G2M DNA content

Animal Models:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ralbp1):

behavior/neurological

cellular

integument

mortality/aging

RALBP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/18 super-pathways (see all 18) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cytoskeleton remodeling_RalB regulation pathway

	Cytoskeleton remodeling RalB regulation pathway	1.00			Cytoskeleton remodeling_RalA regulation pathway	0.23
	Cytoskeleton remodeling_RalB regulation pathway	1.00			Cytoskeleton remodeling RalA regulation pathway	0.23

G-protein signaling Regulation of RAC1 activity

	G-protein signaling Regulation of RAC1 activity	1.00			G-protein signaling Regulation of CDC42 activity	0.25
	G-protein signaling_Regulation of RAC1 activity	0.88			G-protein signaling_Regulation of CDC42 activity	0.25

Doxorubicin Pathway, Pharmacokinetics

Doxorubicin Pathway, Pharmacokinetics

1.00

Doxorubicin Pathway (Cancer Cell), Pharmacodynamics

0.43

Cell death signalling via NRAGE, NRIF and NADE

Rho GTPase cycle

0.25

Signaling by Rho GTPases

0.25

IL-9 Signaling Pathways

G-protein signaling_Cross-talk between Ras-family GTPases

0.14

G-protein signaling Cross-talk between Ras-family GTPases

0.14

Pathway sources
See GeneCards unified pathways
Show all pathways

5 EMD Millipore Pathways for RALBP1

	G-protein signaling Regulation of CDC42 activity
	Cytoskeleton remodeling RalB regulation pathway
	Cytoskeleton remodeling RalA regulation pathway
	G-protein signaling Cross-talk between Ras-family GTPases
	G-protein signaling Regulation of RAC1 activity

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RALBP1

	FGF Pathway
	Molecular Mechanisms of Cancer
	Ras Pathway

1 Cell Signaling Technology (CST) Pathway for RALBP1

Cytoskeletal Signaling

5 GeneGo (Thomson Reuters) Pathways for RALBP1

	G-protein signaling Regulation of RAC1 activity
	G-protein signaling Cross-talk between Ras-family GTPases
	Cytoskeleton remodeling RalB regulation pathway
	G-protein signaling Regulation of CDC42 activity
	Cytoskeleton remodeling RalA regulation pathway

4 BioSystems Pathways for RALBP1

	EGFR1 Signaling Pathway
	RalA downstream regulated genes
	Regulation of CDC42 activity
	Regulation of RAC1 activity

3 Reactome Pathways for RALBP1

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

4 PharmGKB Pathways for RALBP1

	Carbamazepine Pathway, Pharmacokinetics
	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
	Doxorubicin Pathway, Pharmacokinetics
	Vinka Alkaloid Pathway, Pharmacokinetics

2 Kegg Pathways (Kegg details for RALBP1):

	Pathways in cancer
	Pancreatic cancer

RALBP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RALBP1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/82 Interacting proteins for RALBP1 (Q15311^{2, 3} ENSP00000019317⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 82)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TAX1BP1	Q86VP1²^,³, ENSP00000379612⁴	MINT-6505297 MINT-5226536 MINT-6505280 I2D: score=1 STRING: ENSP00000379612
CCL20	P78556²^,³, ENSP00000351671⁴	MINT-5226611 MINT-6505265 I2D: score=1 STRING: ENSP00000351671
RALB	P11234²^,³, ENSP00000272519⁴	MINT-68413 I2D: score=7 STRING: ENSP00000272519
AP2M1	Q96CW1²^,³, ENSP00000292807⁴	MINT-14897 MINT-14899 MINT-14898 I2D: score=3 STRING: ENSP00000292807
UBC	P0CG48²^,³, ENSP00000344818⁴	MINT-5226591 I2D: score=1 STRING: ENSP00000344818

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006200	ATP catabolic process	IDA	10924126
GO:0006810	transport	IDA	11437348
GO:0006935	chemotaxis	TAS	10848592
GO:0007165	signal transduction	TAS	7673236
GO:0007264	small GTPase mediated signal transduction	TAS	--

RALBP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RALBP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RALBP1

2 HMDB Compounds for RALBP1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Glutathione	5-L-Glutamyl-L-cysteinylglycine (see all 32)	70-18-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

10/13 Novoseek chemical compound relationships for RALBP1 gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
s-(2,4-dinitrophenyl)glutathione	78.4	2	2143605 (1), 12545192 (1)
4-hydroxynonenal	71.4	23	12527936 (3), 12422239 (2), 11522795 (2), 15950949 (1) (see all 9)
doxorubicin	60.6	71	11437348 (5), 12527936 (4), 10924126 (4), 12545192 (4) (see all 16)
8-azido-atp	59.3	1	9548754 (1)
atp	32.5	31	12422239 (4), 7907606 (4), 11300797 (3), 15386349 (3) (see all 9)
colchicine	32.4	1	10079207 (1)
vinorelbine	25.8	7	15705900 (5)
daunorubicin	19.2	3	11732624 (1)
vinblastine	15.3	1	15705900 (1)
threonine	15	2	18473820 (1), 17047155 (1)

Search CenterWatch for drugs/clinical trials and news about RALBP1 / RBP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RALBP1 gene:

NM_006788.3

Unigene Cluster for RALBP1:

RalA binding protein 1

Hs.528993 [show with all ESTs]

Unigene Representative Sequence: NM_006788

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000019317(uc002kob.3) ENST00000585015 ENST00000383432(uc002koc.3)

ENST00000458039 ENST00000577221

miRNA Products:		OriGene 3'-UTR Clone: RALBP1 Browse OriGene MicroRNA Expression Plasmids
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		8/69 QIAGEN miScript miRNA Assays for microRNAs that regulate RALBP1 (see all 69):
		hsa-miR-3194-5p hsa-miR-607 hsa-miR-3916 hsa-miR-3613-3p hsa-miR-29a* hsa-miR-4293 hsa-miR-3148 hsa-miR-130b

		SwitchGear 3'UTR luciferase reporter plasmid: RALBP1 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: RALBP1 (NM_006788)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RALBP1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RALBP1

Additional cDNA sequence:

AB209924.1 AK300845.1 AY517554.1 BC013126.1 L42542.1

13 DOTS entries:

DT.92438991 DT.447437 DT.121085537 DT.95347147 DT.99985745 DT.100813889 DT.100813892 DT.92438996

DT.95106068 DT.101983390 DT.75143769 DT.92439007 DT.121085541

24/300 AceView cDNA sequences (see all 300):

AA702950 AW207118 BM762215 CA430233 AW073966 BM785211 AA211324 BM830395

CD365287 AI184819 BX353517 AW513029 BP378641 BM763884 AW025252 AW025261

AI560672 BM739309 CA422971 BX282029 N22101 BC013126 AI002738 AI279667

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for RALBP1 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:
SP2:			-		-		-
SP3:									-
SP4:							-		-

ECgene alternative splicing isoforms for RALBP1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RALBP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

RALBP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RALBP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RALBP1

SOURCE GeneReport for Unigene cluster: Hs.528993

UniProtKB/Swiss-Prot: RBP1_HUMAN, Q15311

Tissue specificity: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes

SABiosciences Custom PCR Arrays for RALBP1

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALBP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for RALBP1 gene from 6/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RALBP1¹	ralA binding protein 1	83.39(n) 93.49(a)		429466 NM_001031575.1 NP_001026746.1
lizard (Anolis carolinensis)	Reptilia	RALBP1⁶	--	89(a)	1 ↔ 1	GL343319.1(597465-614934)
African clawed frog (Xenopus laevis)	Amphibia	rlip1-A-prov²	RalB-binding protein	77.45(n)		AJ304845.1
zebrafish (Danio rerio)	Actinopterygii	ralbp1¹	ralA binding protein 1	71.06(n) 77.83(a)		404612 NM_207080.1 NP_996963.1
fruit fly (Drosophila melanogaster)	Insecta	Rlip^{1 , 3}	RAL GTPase activator³ Ral interacting protein¹	34(a)³ 48.25(n)¹ 38.67(a)¹		93B4³ 42484¹ NM_142676.3¹ NP_650933.2¹
worm (Caenorhabditis elegans)	Secernentea	rlbp-1¹	Protein RLBP-1	41.89(n) 30.27(a)		172530 NM_059739.2 NP_492140.1

ENSEMBL Gene Tree for RALBP1 (if available)
TreeFam Gene Tree for RALBP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RALBP1 gene

ARHGAP30² ARHGAP32² ARHGAP33² ARHGAP31²

1 SIMAP similar gene for RALBP1 using alignment to 3 protein entries: RBP1_HUMAN (see all proteins):

ARHGAP9

RALBP1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for RALBP1
PGOHUM00000240816 PGOHUM00000238278

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs62086113^1,2		--	9473537(+)	`TATAGG/AATAGT`	1	--	us2k¹		2		NA	122
rs111910119^1,2		--	9473671(+)	`TGCTGT/ACCCTC`	1	--	us2k¹		2		CSA WA	120
rs184745817^1,2		--	9473681(+)	`CTAAAC/TTCCCA`	1	--	us2k¹		0	--	--	--	--
rs146480026^1,2		--	9473695(+)	`CTCTAA/GGGTTT`	1	--	us2k¹		0	--	--	--	--
rs11660551^1,2	H	--	9473781(+)	`TACAGA/TTTACT`	1	--	us2k¹		0	--	--	--	--
rs114482090^1,2		--	9473791(+)	`TGGAAG/CCCTCA`	1	--	us2k¹		1		WA	118
rs2120318^1,2	C,F,O,H,	--	9473880(-)	`CATTTA/GAGCCA`	1	--	us2k¹		16		NS EA NA WA CSA	1974
rs141148862^1,2		--	9473883(+)	`CTTAAA/GTGGAA`	1	--	us2k¹		0	--	--	--	--
rs9949585^1,2	C,F,	--	9474035(+)	`CTCCAA/CATGAA`	1	--	us2k¹		1		WA	118
rs189466188^1,2		--	9474180(+)	`CCTCTA/GCTCCC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RALBP1 (9475007 - 9538114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RALBP1
1 CNV: 5045

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RALBP1 for disorders           About GeneDecksing

OMIM gene information: 605801    OMIM disorders: --

14 diseases for RALBP1:    About MalaCards

non-small cell lung carcinoma vascular disease lung cancer prostate cancer

kidney cancer hepatocellular carcinoma colon cancer lung carcinoma

pancreatic cancer prostatitis pancreatitis atherosclerosis

glioblastoma carcinoma

8 Novoseek disease relationships for RALBP1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	53.6	14	16611992 (2), 14668343 (2), 18724939 (1), 19910467 (1) (see all 12)
nsclc	42.5	31	16579994 (6), 12527936 (3), 15705900 (3), 15950949 (1) (see all 8)
tumors	33.6	21	19632771 (3), 16611992 (2), 18724939 (1), 19910467 (1) (see all 13)
cancer	29.1	29	20097178 (3), 18570872 (2), 15386349 (2), 15707977 (1) (see all 13)
cancer lung	21.1	10	15950949 (3), 12527936 (2), 15705900 (2), 16087181 (1) (see all 6)
small cell lung cancer	18	3	15950949 (1), 16087181 (1), 16579994 (1)
leukemia	0	2	11522795 (1), 19417134 (1)
prostate cancer	0	1	20097178 (1)

Human Genome Epidemiology (HuGE) Navigator: RALBP1 (1 document)

Export disorders for RALBP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RALBP1 gene, integrated from 9 sources (see all 163):
(articles sorted by number of sources associating them with RALBP1)

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Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PubMed id 7673236)^{1, 2, 3, 9} Jullien-Flores V.... Camonis J.H. (1995)
Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. (PubMed id 10924126)^{1, 2, 9} Awasthi S.... Awasthi Y.C. (2000)
RLIP76 is the major ATP-dependent transporter of glutathione- conjugates and doxorubicin in human erythrocytes. (PubMed id 11437348)^{1, 2, 9} Sharma R.... Awasthi Y.C. (2001)
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)^{1, 2, 9} Zhang H.... Min W. (2004)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. (PubMed id 12775724)^{1, 2} Rosse C.... Camonis J. (2003)
Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. (PubMed id 9422736)^{1, 2} Ikeda M.... Kikuchi A. (1998)
Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes. (PubMed id 11732624)^{1, 9} Singhal S.S....Awasthi S. (2001)
Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. (PubMed id 12527936)^{1, 9} Singhal S.S....Awasthi S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10928	HGNC: 9841	AceView: RALBP1	Ensembl:ENSG00000017797	euGenes: HUgn10928
ECgene: RALBP1	Kegg: 10928	H-InvDB: RALBP1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RALBP1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RALBP1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RALBP1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RALBP1 gene:
Search GeneIP for patents involving RALBP1

GeneCards and IP:
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ralA binding protein 1

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ralA binding protein 1

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