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Aliases & Descriptions for RALB
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| GTP binding protein 2 | | RAS-like protein B 2 | | v-ral simian leukemia viral oncogene homolog B 2 | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 2 |
|
| | Search outside databases for aliases for RALB genePrevious GC identifers: GC02P118215 GC02P118931 GC02P120917 GC02P121105 |
Summaries for RALB(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RALB: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq] Gene Wiki entry for RALB |
Genomic Location for RALB
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RALB gene 
Entrez Gene cytogenetic band: 2cen-q13 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2RALB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P120726:
(about GC identifiers)
Start:
|
120,726,884 bp from pter |
End:
|
120,768,756 bp from pter |
Size:
|
41,873 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022135.15
| Proteins for RALB
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RALB_HUMAN, P11234 (See
protein sequence)Recommended Name: Ras-related protein Ral-B precursor Size: 206 amino acids; 23409 Da
Subunit: Interacts with EXOC8. Interacts with RALBP1 via its effector domain
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :2KE5 (3D)
 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002872.1
ENSEMBL proteins: ENSP00000272519 ENSP00000384328 ENSP00000365398
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RALB 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- | | GO:0005886 | plasma membrane |
IEA | -- | About this table
Antibodies for RALB: Assays for RALB: | Protein
Domains/ Families for RALB(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11234
ProtoNet protein and cluster: P11234 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003577 Ras small GTPase
UniProtKB/Swiss-Prot: RALB_HUMAN, P11234Similarity: Belongs to the small GTPase superfamily. Ras family | Gene Function for RALB
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002881
Applied Biosystems Silencer® siRNAs for RALB
Sigma-Aldrich siRNA and siRNA Panels for RALB  Sigma-Aldrich shRNA for RALB  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002881                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002881                                  untagged cDNA clone in CMV expression vector: NM_002881 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002881
Genatlas biochemistry entry for RALB:simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for RALB
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for RALB (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for RALB 
5/15 Interacting proteins for RALB (ENSP000003653983 P112342) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007265 | Ras protein signal transduction |
EXP | 11520933 | About this table
|
Drugs & Compounds for RALB(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for RALB 1 Novoseek chemical compound relationship for RALB gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gtp |
27.81 |
5 |
17202486 (3) |
About this table
|
Transcripts for RALB(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002881
Sigma-Aldrich siRNA and siRNA Panels for RALB  Sigma-Aldrich shRNA for RALB  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002881 REFSEQ mRNAs for RALB gene: NM_002881.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002881               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002881                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002881                                  untagged cDNA clone in CMV expression vector: NM_002881  Additional cDNA sequence: AF493911.1 AK127675.1 AK303214.1 AK304588.1 AK312453.1 BC018163.1 BT006953.1 CR601386.1 CR606313.1 M35416.1 X15015.1 10 DOTS entries: DT.446881 DT.91778810 DT.120960916 DT.95288583 DT.120960951 DT.101959747 DT.120960967 DT.95148937 DT.120960925 DT.97771381 24/302 AceView cDNA sequences (see all 302
):AL542135 N47529 AI198007 AA305022 BU172083 BM852898 AA621513 BC018163 CR601386 BM793998 BI855857 BU158275 AI684110 AA992114 BQ921293 BM828921 AA318570 AI201792 BP343963 BP342150 BF513052 BI769608 BQ215445 BU166312
highest scoring ESTs for RALB:M35416 AA080893 AA084543 AA187314 AA305022 AA318570 AA374810 AA397773 AA398232 AA551281 Unigene Cluster for RALB: V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) Hs.469820 [show with all ESTs]Unigene Representative Sequence: AK127675
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RALB (see all 10
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | |
| SP1: | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RALB
3 Ensembl transcripts including schematic representations: ENST00000272519
ENST00000404963
ENST00000376224
|
Expression for RALB
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RALB expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RALB
1 / 2 / 3 6 probe-sets matching RALB gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCTTTTTTT
SOURCE GeneReport for Unigene cluster: Hs.469820
Expression variation in blood from EXPOLDB for RALB |
Orthologs for RALB
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RALB gene from 5/13 species (see all 13
)
About this table Species with no ortholog for RALB
ENSEMBL Gene Tree for RALB | Paralogs for RALB(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RALB gene
- RALA2
|
SNPs/Variants for RALB(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RALB (up to first 250kb)
|
Disorders & Mutations for RALB
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 179551
4 Novoseek disease relationships for RALB gene
About this table
|
Medical News for RALB(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RALB (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/37 PubMed articles for RALB gene (see all 37
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)3, 4 Moskalenko S.... White M.A. (2003)
- Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PubMed id 7673236)3, 4 Jullien-Flores V.... Camonis J.H. (1995)
- Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein. (PubMed id 2120779)3, 4 Hsieh C.-L.... Francke U. (1990)
- Coding sequences of human ralA and ralB cDNAs. (PubMed id 2662142)3, 4 Chardin P. and Tavitian A. (1989)
- Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets. (PubMed id 8972729)1, 3 Jilkina O. and Bhullar R.P. (1996)
- Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PubMed id 17875936)1, 3 Falsetti S.C....Sebti S.M. (2007)
- Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. (PubMed id 17174914)1, 3 Lim K.H....Counter C.M. (2006)
- Calmodulin binds RalA and RalB and is required for the thrombin-induced activation of Ral in human platelets. (PubMed id 12034722)1, 3 Clough R.R....Bhullar R.P. (2002)
- Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PubMed id 18756269)1, 3 Cascone I....Camonis J. (2008)
|
Search for RALB
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RALB
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RALB
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RALB(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RALB(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RALB:

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Incremental update: 13 Oct 2009
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