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RALB Gene

protein-coding   GIFtS: 68
GCID: GC02P120997

V-Ral Simian Leukemia Viral Oncogene Homolog B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Ral Simian Leukemia Viral Oncogene Homolog B1 2
Ras Related GTP Binding Protein B1 2
RAS-Like Protein B2
Ras-Related Protein Ral-B2
V-Ral Simian Leukemia Viral Oncogene Homolog B (Ras Related; GTP Binding
Protein)2

External Ids:    HGNC: 98401   Entrez Gene: 58992   Ensembl: ENSG000001441187   OMIM: 1795515   UniProtKB: P112343   

Export aliases for RALB gene to outside databases

Previous GC identifers: GC02P118215 GC02P118931 GC02P120917 GC02P121105 GC02P120726 GC02P113335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RALB Gene:
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins.
GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface
receptors. (provided by RefSeq, Jul 2008)

GeneCards Summary for RALB Gene:
RALB (v-ral simian leukemia viral oncogene homolog B) is a protein-coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RALB_HUMAN, P11234
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional
exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is
required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for
suppression of apoptosis

Gene Wiki entry for RALB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RALB gene promoter:
         RFX1   GCNF   LCR-F1   MZF-1   HEN1   NRF-2   GCNF-1   FOXO4   SEF-1 (1)   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RALB promoter sequence
   Search Chromatin IP Primers for RALB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q14.2   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

RALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALB gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P120997:  view genomic region     (about GC identifiers)

Start:
120,997,640 bp from pter      End:
121,052,289 bp from pter
Size:
54,650 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RALB_HUMAN, P11234 (See protein sequence)
Recommended Name: Ras-related protein Ral-B precursor  
Size: 206 amino acids; 23409 Da
Subunit: Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain
2 PDB 3D structures from and Proteopedia for RALB:
2KE5 (3D)        2KWI (3D)    
Secondary accessions: Q53T32

Explore the universe of human proteins at neXtProt for RALB: NX_P11234

Explore proteomics data for RALB at MOPED

Post-translational modifications: 

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does
    not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and
    farnesyltransferase I inhibitors (FTIs)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RALB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002872.1  
    ENSEMBL proteins: 
     ENSP00000402866   ENSP00000272519   ENSP00000414224   ENSP00000393782   ENSP00000398162  
     ENSP00000407062   ENSP00000438764   ENSP00000384328  
    Reactome Protein details: P11234

    RALB Human Recombinant Protein Products:

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    antibodies-online proteins for RALB (12 products) 

     
    antibodies-online peptides for RALB

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    antibodies-online antibodies for RALB (48 products) 

    RALB Assay Products:

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    Cloud-Clone Corp. ELISAs for RALB
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    antibodies-online kits for RALB (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028412 Ral
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P11234

    ProtoNet protein and cluster: P11234

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RALB_HUMAN, P11234
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RALB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RALB_HUMAN, P11234
    Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
    migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
    functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
    dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional
    exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is
    required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for
    suppression of apoptosis
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by
    a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)

         Genatlas biochemistry entry for RALB:
    simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA19166349
    GO:0005515protein binding IPI19166349
    GO:0005525GTP binding IDA19166349
         
    Find genes that share ontologies with RALB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RALB:
     Decreased G3BP1 protein expres 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ralb):
     cellular  embryogenesis  growth/size/body  mortality/aging  nervous system 
     normal  tumorigenesis 

    Find genes that share phenotypes with RALB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ralbtm1.1Cjm for RALB

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALB
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    Selected qRT-PCR Assays for microRNAs that regulate RALB (see all 25):
    hsa-miR-3194-5p hsa-miR-4288 hsa-let-7d hsa-miR-1271 hsa-miR-632 hsa-let-7c hsa-miR-340 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidRALB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RALB_HUMAN, P11234: Cell membrane; Lipid-anchor; Cytoplasmic side. Note=During late cytokinesis localizes at the
    midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton1
    endosome1
    extracellular1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IDA17875936
    GO:0016020membrane ----
    GO:0030496midbody IDA18756269

    Find genes that share ontologies with RALB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RALB About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Signalling to ERKs
    Signalling to ERKs0.73
    p38MAPK events0.00
    Signalling to RAS0.73
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    4GPCR Pathway
    Ras Pathway0.73
    5Akt Signaling
    p38 Signaling0.60


    Find genes that share SuperPaths with RALB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RALB
        FGF Pathway
    Molecular Mechanisms of Cancer
    p38 Signaling
    Phospholipase-C Pathway
    Ras Pathway

    1 Cell Signaling Technology (CST) Pathway for RALB
        Cytoskeletal Signaling

    1 GeneGo (Thomson Reuters) Pathway for RALB
        Cytoskeleton remodeling RalB regulation pathway

    2 BioSystems Pathways for RALB
        EGFR1 Signaling Pathway
    CXCR4-mediated signaling events


    1 Reactome Pathway for RALB
        p38MAPK events


    4 Kegg Pathways  (Kegg details for RALB):
        Ras signaling pathway
    Rap1 signaling pathway
    Pathways in cancer
    Pancreatic cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RALB
    Interactions:

        GeneGlobe Interaction Network for RALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RALB (P112342, 3 ENSP000002725194) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-16957 MINT-16956 MINT-16955 I2D: score=4 
    CALM3P621582, 3MINT-16957 MINT-16956 MINT-16955 I2D: score=4 
    CALM1P621582, 3, ENSP000003494674MINT-16957 MINT-16956 MINT-16955 I2D: score=4 STRING: ENSP00000349467
    RALBP1Q153112, 3, ENSP000000193174MINT-68413 I2D: score=7 STRING: ENSP00000019317
    ATG12O948173, ENSP000002744594I2D: score=1 STRING: ENSP00000274459
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    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IDA18756269
    GO:0001928regulation of exocyst assembly ISS--
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006913nucleocytoplasmic transport ----

    Find genes that share ontologies with RALB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALB

    1 Novoseek inferred chemical compound relationship for RALB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 53.9 7 17202486 (3), 19636899 (1), 19166349 (1)



    Find genes that share compounds with RALB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RALB gene: 
    NM_002881.2  

    Unigene Cluster for RALB:

    V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
    Hs.469820  [show with all ESTs]
    Unigene Representative Sequence: AK127675
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000447591 ENST00000272519(uc010yys.2 uc002tmk.3 uc010yyt.2)
    ENST00000420510 ENST00000431732 ENST00000470417 ENST00000412383 ENST00000449649
    ENST00000474855 ENST00000404963(uc002tml.3)
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    Additional mRNA sequence: 

    AF493911.1 AK127675.1 AK303214.1 AK304588.1 AK312453.1 BC018163.1 BT006953.1 M35416.1 
    X15015.1 

    10 DOTS entries:

    DT.446881  DT.91778810  DT.120960916  DT.95288583  DT.120960951  DT.101959747  DT.120960967  DT.95148937 
    DT.120960925  DT.97771381 

    Selected AceView cDNA sequences (see all 302):

    BQ215445 AW518646 BU734695 BM852898 AK127675 BX426908 AA992114 CD703145 
    BU158275 BF513052 AI201792 N33170 AI056062 AW188995 AW949420 AA318570 
    T29437 BU172083 CR601386 BM828921 BQ637452 BQ694281 AI198007 N47529 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RALB (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                          -     -                 -                                             
    SP2:                          -     -                       -                                       
    SP3:                          -     -                       -                                       
    SP4:                          -     -                                                               
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for RALB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RALB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTTTTTTT
    RALB Expression
    About this image


    RALB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Colon (Gastrointestinal Tract)
     
     Kidney (Urinary System)
     
     Lung (Respiratory System)
     
     Esophagus (Gastrointestinal Tract)
    RALB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.469820
        Custom PCR Arrays for RALB
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RALB gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ralb1 , 5 v-ral simian leukemia viral oncogene homolog B (ras more1, 5 85.28(n)1
    95.15(a)1
      1 (52.29 cM)5
    641431  NM_022327.51  NP_071722.11 
     1194703055 
    chicken
    (Gallus gallus)
    Aves RALB1 v-ral simian leukemia viral oncogene homolog B (ras more 83.98(n)
    97.57(a)
      424237  XM_422085.3  XP_422085.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALB6
    v-ral simian leukemia viral oncogene homolog B
    96(a)
    1 ↔ 1
    1(85070505-85096848)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.56592 Xenopus laevis mRNA for Ral B protein 80.69(n)    Y16259.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ralba1 v-ral simian leukemia viral oncogene homolog Ba (ras more 77.83(n)
    92.23(a)
      445255  NM_001003649.1  NP_001003649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rala3 dorsal closure RAS small monomeric
    GTPase
    75(a)   3E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea Y53G8AR.33   -- 68(a)   III(3384386-3389320)   --


    ENSEMBL Gene Tree for RALB (if available)
    TreeFam Gene Tree for RALB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RALB gene
    REM12  RALA2  RRAS2  ERAS2  RRAD2  NRAS2  REM22  KRAS2  
    GEM2  RRAS22  HRAS2  MRAS2  
    Selected SIMAP similar genes for RALB using alignment to 8 protein entries:     RALB_HUMAN (see all proteins) (see all similar genes):
    K-RAS    RALA    N-ras    KRAS    c-bas/has    RAP1B
    NRAS    HRAS    RRAS2    RAP1A    RRAS    DKFZp547A0616
    RAP2B    RIT2    RAP2C    RAP2A    RERG    MRAS

    Find genes that share paralogs with RALB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RALB (see all 951)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1877105871,2
    --121008515(+) AGGAGA/TCCCAG 1 -- us2k10--------
    rs1387570471,2
    --121008571(+) TTCTCA/CGAAAG 1 -- us2k10--------
    rs1931001311,2
    --121008674(+) GATGGA/GGGGCA 1 -- us2k10--------
    rs38064911,2
    C,F,H--121008675(-) CTGCCC/TCCCAT 1 -- us2k111Minor allele frequency- T:0.40EA NA WA CSA 1677
    rs729568461,2
    C,F--121008798(+) ATTTGA/GCAAAG 1 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1856742381,2
    C--121008840(+) CTGCAC/TGCGGT 1 -- us2k10--------
    rs1404145251,2
    C--121008901(+) ATCACA/GCACTT 1 -- us2k10--------
    rs1503396471,2
    C--121008935(+) GGCAAA/TCACTA 1 -- us2k10--------
    rs1874890261,2
    --121009373(+) ATTCTC/TCTGAT 1 -- us2k10--------
    rs1380373801,2
    C--121009420(+) GTAAAG/TCTTCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALB (120997640 - 121052289 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RALB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2894CNV Loss18451855
    nsv508164CNV Loss20534489
    nsv834346CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RALB
    DNA2.0 Custom Variant and Variant Library Synthesis for RALB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179551    OMIM disorders: --


    Find genes that share disorders with RALB           About GenesLikeMe

    4 Novoseek inferred disease relationships for RALB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic carcinoma 39.2 2 17174914 (1), 16757353 (1)
    cancer 28 9 16103060 (3), 17875936 (1), 17018283 (1), 17706599 (1) (see all 5)
    metastasis 5.77 3 17174914 (2), 17706599 (1)
    tumors 3.99 7 17875936 (2), 17174914 (1), 16757353 (1), 17018283 (1) (see all 5)

    Genetic Association Database (GAD): RALB
    Human Genome Epidemiology (HuGE) Navigator: RALB (1 document)

    Export disorders for RALB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RALB gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with RALB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PubMed id 17875936)1, 2, 9 Falsetti S.C.... Sebti S.M. (Mol. Cell. Biol. 2007)
    2. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PubMed id 18756269)1, 2, 9 Cascone I.... Camonis J. (EMBO J. 2008)
    3. Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. (PubMed id 19166349)1, 2, 9 Fenwick R.B.... Owen D. (Biochemistry 2009)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)1, 2 Moskalenko S.... White M.A. (J. Biol. Chem. 2003)
    7. Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity. (PubMed id 7673236)1, 2 Jullien-Flores V.... Camonis J.H. (J. Biol. Chem. 1995)
    8. Chromosomal localization and cDNA sequence of human ralB, a GTP binding protein. (PubMed id 2120779)1, 2 Hsieh C.-L.... Francke U. (Somat. Cell Mol. Genet. 1990)
    9. Coding sequences of human ralA and ralB cDNAs. (PubMed id 2662142)1, 2 Chardin P. and Tavitian A. (Nucleic Acids Res. 1989)
    10. Generation of antibodies specific for the RalA and RalB GTP-binding proteins and determination of their concentration and distribution in human platelets. (PubMed id 8972729)1, 9 Jilkina O. and Bhullar R.P. (Biochim. Biophys. Acta 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5899 HGNC: 9840 AceView: RALB Ensembl:ENSG00000144118 euGenes: HUgn5899
    ECgene: RALB Kegg: 5899 H-InvDB: RALB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RALB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RALB gene:
    Search GeneIP for patents involving RALB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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