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RALB Gene

protein-coding   GIFtS: 66

GC02P120726
v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
GTP binding protein 2
RAS-like protein B 2
v-ral simian leukemia viral oncogene homolog B 2
v-ral simian leukemia viral oncogene homolog B (ras
related; GTP binding protein) 2
External Ids
HGNC: 98401
Entrez Gene: 58992
UniProtKB: P112343
Ensembl: ENSG000001441187
Search outside databases for aliases for RALB gene

Previous GC identifers: GC02P118215 GC02P118931 GC02P120917 GC02P121105

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RALB:
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family
of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy
of certain cell surface receptors. [provided by RefSeq]

Gene Wiki entry for RALB
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the RALB gene  

Entrez Gene cytogenetic band: 2cen-q13   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q14.2

RALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P120726:     (about GC identifiers)

Start:
120,726,884 bp from pter
End:
120,768,756 bp from pter
Size:
41,873 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_022135.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: RALB_HUMAN, P11234 (See protein sequence)
Recommended Name: Ras-related protein Ral-B precursor  
Size: 206 amino acids; 23409 Da
Subunit: Interacts with EXOC8. Interacts with RALBP1 via its effector domain
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)
PDB structures from and Proteopedia :
2KE5 (3D)    

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_002872.1  

    ENSEMBL proteins: 
    ENSP00000272519 ENSP00000384328 ENSP00000365398 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for RALB  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (RALA+RALB, RALB)
    Human Recombinant Proteins from Abnova (RALB)
                  OriGene Purified Recombinant Human Protein: RALB 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for RALB: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of RALB
    Sigma-Aldrich Antibodies for RALB
    R&D Systems Antibodies for RALB
    Cell Signaling Technology (CST) Antibodies for RALB 
    Antibodies from Abcam (RALA+RALB, RALB), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (RALB)
    Novus Biologicals Antibodies for RALB

    Assays for RALB: 
    Browse Invitrogen for biochemical assays
    Millipore Kits and Assays for the Analysis of RALB
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR003577 GTPase_Ras
     IPR001806 Ras_GTPase
     IPR005225 Small_GTP_bd
     IPR015591 Ras_Ral_related
     IPR013753 Ras


       GeneDecks  RALB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P11234

    ProtoNet protein and cluster: P11234

    2 Blocks protein families:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RALB_HUMAN, P11234
    Similarity: Belongs to the small GTPase superfamily. Ras family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RALB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RALB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002881

                  Applied Biosystems Silencer® siRNAs for RALB

                  Sigma-Aldrich siRNA and siRNA Panels for RALB  
                         Sigma-Aldrich shRNA for RALB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for RALB
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002881
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002881
                                     untagged cDNA clone in CMV expression vector: NM_002881 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002881

    Genatlas biochemistry entry for RALB:
    simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0005515 protein binding IPI7673236
    GO:0005525 GTP binding TAS2120779
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for RALB
     Cytoskeleton remodeling RalB regulation pathway

       GeneDecks  RALB for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  RALB  (Your Favorite Gene powered by Ingenuity) 
     Molecular Mechanisms of Cancer
     Integrin Signaling

       GeneDecks  RALB for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for RALB):
     hsa05200 Pathways in cancer
     hsa05212 Pancreatic cancer

       GeneDecks  RALB for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  RALB 


    5/15 Interacting proteins for RALB (ENSP000003653983 P112342) via UniProtKB, MINT, and/or STRING (see all 15 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM3P621582STRING (score=.94) MINT-16957 MINT-16956 MINT-16955
    RALBP1Q153112STRING (score=.997) MINT-68413
    CALM1P621582MINT-16957 MINT-16956 MINT-16955
    CALM2P621582MINT-16957 MINT-16956 MINT-16955
    EXOC2ENSP000002304493STRING (score=.972)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007265 Ras protein signal transduction EXP11520933
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for RALB
    1 Novoseek chemical compound relationship for RALB gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 27.81 5 17202486 (3)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (RALB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RALB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002881

                  Sigma-Aldrich siRNA and siRNA Panels for RALB  
                         Sigma-Aldrich shRNA for RALB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002881  

    REFSEQ mRNAs for RALB gene: 

    NM_002881.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002881  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002881
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002881
                                     untagged cDNA clone in CMV expression vector: NM_002881 

    Additional cDNA sequence: 

    AF493911.1 AK127675.1 AK303214.1 AK304588.1 AK312453.1 BC018163.1 BT006953.1 CR601386.1 
    CR606313.1 M35416.1 X15015.1 

    10 DOTS entries:

    DT.446881  DT.91778810  DT.120960916  DT.95288583  DT.120960951  DT.101959747  DT.120960967  DT.95148937 
    DT.120960925  DT.97771381 

    24/302 AceView cDNA sequences (see all 302 ):

    AL542135 N47529 AI198007 AA305022 BU172083 BM852898 AA621513 BC018163 
    CR601386 BM793998 BI855857 BU158275 AI684110 AA992114 BQ921293 BM828921 
    AA318570 AI201792 BP343963 BP342150 BF513052 BI769608 BQ215445 BU166312 

    highest scoring ESTs for RALB:

    M35416 AA080893 AA084543 AA187314 AA305022 AA318570 AA374810 AA397773 AA398232 AA551281 

    Unigene Cluster for RALB:

    V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
    Hs.469820  [show with all ESTs]
    Unigene Representative Sequence: AK127675


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RALB (see all 10 )

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
    SP1:                          -     -                 -                                             
    SP2:                          -     -                       -                                       
    SP3:                          -     -                       -                                       
    SP4:                          -     -                                                               
    SP5:                                                        -                                       

    About this scheme

    ECgene alternative splicing isoforms for RALB

    3 Ensembl transcripts including schematic representations:
    ENST00000272519  ENST00000404963  ENST00000376224  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    RALB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for RALB

    1 / 2 / 3

    6 probe-sets matching RALB gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32776_at2, 3 U95-A 1 1.00 1.00 0.99 1.15 M35416 1.00 1.00 1.00 1

    228_at2, 3 U95-A 1 1.00 1.00 0.98 0.85 M35416 1.00 1.00 1.00 1

    202101_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002881 0.60 1.00 0.82 1

    202100_at2, 3 U133-A 1 1.00 1.00 -- -- BG169673 0.80 1.00 0.91 1

    202101_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    202100_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  RALB for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GGCTTTTTTT

    SOURCE GeneReport for Unigene cluster: Hs.469820

    Expression variation in blood from EXPOLDB for RALB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for RALB gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    RALB1   -- v-ral simian leukemia viral oncogene homolog B (ras more 91.59(n)
    98.06(a)
    483881  XM_541001.2  XP_541001.2 
    chimpanzee
    (Pan troglodytes)
    RALB1   -- v-ral simian leukemia viral oncogene homolog B (ras more 100(n)
    100(a)
    750044  XM_001172858.1  XP_001172858.1 
    cow
    (Bos taurus)
    RALB1   -- v-ral simian leukemia viral oncogene homolog B (ras more 89.32(n)
    98.54(a)
    505238  XM_581493.3  XP_581493.3 
    rat
    (Rattus norvegicus)
    Ralb1   -- v-ral simian leukemia viral oncogene homolog B (ras more 84.14(n)
    95.63(a)
    116546  NM_053821.2  NP_446273.1 
    mouse
    (Mus musculus)
    Ralb1, 5 15
    v-ral simian leukemia viral oncogene homolog B (ras more1, 5 85.28(n)1
    95.15(a)1
    641431  NM_022327.41  NP_071722.11 
     AA3868605  AI8472365  (see all 15)
    About this table        Species with no ortholog for RALB

    ENSEMBL Gene Tree for RALB
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for RALB gene
    RALA2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/319 NCBI SNPs in RALB are shown (see all 319 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 87)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10655181,2
    A,C,F,H120767459(+) GACTCT/AGTGGC 1 -- ut31 ese38Minor allele frequency- A:0.43EA NA EU WA 1836
    rs87061,2
    C,F,H120767864(+) ATTGCG/ACCAGA 1 -- ut31 ese38Minor allele frequency- A:0.03MN NA EU EA WA 732
    --
    rs75783691,2
    A,C,F120768921(+) AGTATC/TAACCG 1 -- ng313Minor allele frequency- T:0.44NA 136
    rs104965611,2
    C,F,H120768794(+) CTTTTG/TTCATA 1 -- ng3117Minor allele frequency- N:0.00NS EU EA WA NA 1154
    rs38064911,2
    C,F120725145(-) CTGCCC/TCCCAT 1 -- ng511Minor allele frequency- T:0.39EA 1306
    rs11373851,2
    C,F120768738(+) TGAATT/AAAAAA 1 -- ut311Minor allele frequency- A:0.35MN 184
    --
    rs170500871,2
    F120767610(+) AGAGAA/GAGAAT 1 -- ut31 trp33Minor allele frequency- G:0.02NA 134
    rs130223561,2
    H120769084(+) cgatcA/Ccagtg 1 -- ng314Minor allele frequency- C:0.00EU EA WA 420
    rs9347221,2
    F120726913(+) CCGGCA/TGCTCA 1 -- ut513Minor allele frequency- T:0.50MN EA 1436
    rs115452931,2
    C120752803(+) CTGACA/GCTTCA 1 T/T syn10--------
    About this table

    HapMap Linkage Disequilibrium images for RALB (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 179551

    4 Novoseek disease relationships for RALB gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    pancreatic carcinoma 43.62 2 17174914 (1), 16757353 (1)
    cancer 28.64 8 16103060 (3), 17875936 (1), 17706599 (1), 17018283 (1)
    metastasis 11.86 3 17174914 (2), 17706599 (1)
    tumors 0.13 7 17875936 (2), 17174914 (1), 16757353 (1), 17018283 (1) (see all 5)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/37 PubMed articles for RALB gene (see all 37 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 5899 HGNC: 9840 AceView: RALB Ensembl:ENSG00000144118 euGenes: HUgn5899
    ECgene: RALB H-InvDB: RALB
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for RALB Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for RALB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Explore super-pooled esiRNAs Proteins for RALB
     Lentivirus-delivered shRNAs for RALB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (RALA+RALB, RALB)
     Antibodies (RALA+RALB, RALB)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for RALB




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for RALB

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