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Aliases for RALB Gene

Aliases for RALB Gene

  • RAS Like Proto-Oncogene B 2 3
  • V-Ral Simian Leukemia Viral Oncogene Homolog B 2
  • Ras Related GTP Binding Protein B 2
  • RALB Ras Like Proto-Oncogene B 5

External Ids for RALB Gene

Previous GeneCards Identifiers for RALB Gene

  • GC02P118215
  • GC02P118931
  • GC02P120917
  • GC02P121105
  • GC02P120726
  • GC02P120997
  • GC02P113335

Summaries for RALB Gene

Entrez Gene Summary for RALB Gene

  • This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008]

GeneCards Summary for RALB Gene

RALB (RAS Like Proto-Oncogene B) is a Protein Coding gene. Diseases associated with RALB include Pancreatic Cancer. Among its related pathways are Pathways in cancer and Signaling by GPCR. GO annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALA.

UniProtKB/Swiss-Prot for RALB Gene

  • Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.

Gene Wiki entry for RALB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALB Gene

Genomics for RALB Gene

Regulatory Elements for RALB Gene

Enhancers for RALB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RALB on UCSC Golden Path with GeneCards custom track

Genomic Location for RALB Gene

Chromosome:
2
Start:
120,240,064 bp from pter
End:
120,294,713 bp from pter
Size:
54,650 bases
Orientation:
Plus strand

Genomic View for RALB Gene

Genes around RALB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALB Gene

Proteins for RALB Gene

  • Protein details for RALB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11234-RALB_HUMAN
    Recommended name:
    Ras-related protein Ral-B
    Protein Accession:
    P11234
    Secondary Accessions:
    • B4E040
    • Q53T32
    • Q6ZS74

    Protein attributes for RALB Gene

    Size:
    206 amino acids
    Molecular mass:
    23409 Da
    Quaternary structure:
    • Interacts with EXOC2 and EXOC8. Interacts with RALBP1 via its effector domain.

    Three dimensional structures from OCA and Proteopedia for RALB Gene

    Alternative splice isoforms for RALB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RALB Gene

Post-translational modifications for RALB Gene

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RALB Gene

No data available for DME Specific Peptides for RALB Gene

Domains & Families for RALB Gene

Gene Families for RALB Gene

Graphical View of Domain Structure for InterPro Entry

P11234

UniProtKB/Swiss-Prot:

RALB_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RALB: view

Function for RALB Gene

Molecular function for RALB Gene

GENATLAS Biochemistry:
simian leukemia viral (v-ral) oncogene homolog B,Ras oncogene superfamily member
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Required for suppression of apoptosis.

Gene Ontology (GO) - Molecular Function for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 19166349
GO:0005515 protein binding IPI 7673236
GO:0005525 GTP binding IMP 24056301
GO:0019003 GDP binding IDA 24056301
GO:0031625 ubiquitin protein ligase binding IPI 24056301
genes like me logo Genes that share ontologies with RALB: view
genes like me logo Genes that share phenotypes with RALB: view

Animal Models for RALB Gene

MGI Knock Outs for RALB:

Animal Model Products

CRISPR Products

miRNA for RALB Gene

miRTarBase miRNAs that target RALB

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RALB

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALB Gene

Localization for RALB Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALB Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=During late cytokinesis localizes at the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALB Gene COMPARTMENTS Subcellular localization image for RALB gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 1
endosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000145 colocalizes_with exocyst IDA 24056301
GO:0005776 colocalizes_with autophagosome IDA 24056301
GO:0005886 plasma membrane IDA 17875936
GO:0030496 midbody IDA 18756269
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with RALB: view

Pathways & Interactions for RALB Gene

genes like me logo Genes that share pathways with RALB: view

Pathways by source for RALB Gene

SIGNOR curated interactions for RALB Gene

Other effect:

Gene Ontology (GO) - Biological Process for RALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IDA 18756269
GO:0001928 regulation of exocyst assembly ISS --
GO:0001934 positive regulation of protein phosphorylation IMP 24056301
GO:0006915 apoptotic process IEA --
GO:0007165 signal transduction TAS 2120779
genes like me logo Genes that share ontologies with RALB: view

Drugs & Compounds for RALB Gene

(1) Additional Compounds for RALB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALB: view

Transcripts for RALB Gene

Unigene Clusters for RALB Gene

V-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RALB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RALB Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8
SP1: - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - -
SP9: -
SP10: -

Relevant External Links for RALB Gene

GeneLoc Exon Structure for
RALB
ECgene alternative splicing isoforms for
RALB

Expression for RALB Gene

mRNA expression in normal human tissues for RALB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RALB Gene

This gene is overexpressed in Whole Blood (x7.7).

Protein differential expression in normal tissues from HIPED for RALB Gene

This gene is overexpressed in Uterus (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RALB Gene



Protein tissue co-expression partners for RALB Gene

NURSA nuclear receptor signaling pathways regulating expression of RALB Gene:

RALB

SOURCE GeneReport for Unigene cluster for RALB Gene:

Hs.469820
genes like me logo Genes that share expression patterns with RALB: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for RALB Gene

Orthologs for RALB Gene

This gene was present in the common ancestor of animals.

Orthologs for RALB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RALB 34
  • 89.32 (n)
  • 98.54 (a)
RALB 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALB 34
  • 91.59 (n)
  • 98.06 (a)
RALB 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RALB 34
  • 100 (n)
  • 100 (a)
RALB 35
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ralb 34
  • 84.14 (n)
  • 95.63 (a)
mouse
(Mus musculus)
Mammalia Ralb 16
Ralb 35
  • 95 (a)
OneToOne
Ralb 34
  • 85.28 (n)
  • 95.15 (a)
oppossum
(Monodelphis domestica)
Mammalia RALB 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALB 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves RALB 34
  • 83.98 (n)
  • 97.57 (a)
RALB 35
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALB 35
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5659 34
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7039 34
zebrafish
(Danio rerio)
Actinopterygii ralba 34
  • 77.83 (n)
  • 92.23 (a)
ralba 35
  • 94 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9969 34
fruit fly
(Drosophila melanogaster)
Insecta Rala 36
  • 75 (a)
Rala 35
  • 73 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.3 36
  • 68 (a)
ral-1 35
  • 52 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12282 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10753 35
  • 65 (a)
OneToMany
Species where no ortholog for RALB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALB Gene

ENSEMBL:
Gene Tree for RALB (if available)
TreeFam:
Gene Tree for RALB (if available)

Paralogs for RALB Gene

Paralogs for RALB Gene

genes like me logo Genes that share paralogs with RALB: view

Variants for RALB Gene

Sequence variations from dbSNP and Humsavar for RALB Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1065518 -- 120,293,413(+) GACTC(A/T)GTGGC utr-variant-3-prime
rs1137385 -- 120,294,692(+) TGAAT(A/T)AAAAA utr-variant-3-prime
rs1370379 -- 120,257,013(+) TCTTC(C/T)GGTTC intron-variant
rs1370380 -- 120,257,319(+) TAGCA(A/G)TTCTT intron-variant
rs6705475 -- 120,283,586(+) GCAGT(A/C)AGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALB Gene

Variant ID Type Subtype PubMed ID
dgv2226e59 CNV duplication 20981092
nsv1000477 CNV gain 25217958
nsv1109282 CNV deletion 24896259
nsv2894 CNV deletion 18451855
nsv508164 CNV deletion 20534489
nsv834346 CNV gain 17160897

Variation tolerance for RALB Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.55; 11.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALB Gene

Disorders for RALB Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search RALB in MalaCards View complete list of genes associated with diseases

Relevant External Links for RALB

Genetic Association Database (GAD)
RALB
Human Genome Epidemiology (HuGE) Navigator
RALB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALB
genes like me logo Genes that share disorders with RALB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALB Gene

Publications for RALB Gene

  1. Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding. (PMID: 19166349) Fenwick R.B. … Owen D. (Biochemistry 2009) 3 4 22 65
  2. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PMID: 18756269) Cascone I. … Camonis J. (EMBO J. 2008) 3 4 22 65
  3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PMID: 17875936) Falsetti S.C. … Sebti S.M. (Mol. Cell. Biol. 2007) 3 4 22 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  5. The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells. (PMID: 18227351) de Gorter D.J. … Spaargaren M. (Blood 2008) 3 22 65

Products for RALB Gene

Sources for RALB Gene

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