Aliases for RALA Gene
External Ids for RALA Gene
Previous HGNC Symbols for RALA Gene
Previous GeneCards Identifiers for RALA Gene
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]
GeneCards Summary for RALA Gene
RALA (V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)) is a Protein Coding gene. Diseases associated with RALA include leukemia and pancreatic cancer. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is HRAS.
UniProtKB/Swiss-Prot for RALA Gene
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.