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Aliases for RALA Gene

Aliases for RALA Gene

  • V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related) 2 3
  • Ras Family Small GTP Binding Protein RALA 2 3
  • Ras Related GTP Binding Protein A 2 3
  • Ras-Related Protein Ral-A 2 3
  • RAS-Like Protein A 2 3
  • RAL 3 4

External Ids for RALA Gene

Previous HGNC Symbols for RALA Gene

  • RAL

Previous GeneCards Identifiers for RALA Gene

  • GC07P039372
  • GC07P039403
  • GC07P039436
  • GC07P039630
  • GC07P039547

Summaries for RALA Gene

Entrez Gene Summary for RALA Gene

  • The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for RALA Gene

RALA (V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include GTP binding and Edg-2 lysophosphatidic acid receptor binding. An important paralog of this gene is HRAS.

UniProtKB/Swiss-Prot for RALA Gene

  • Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Gene Wiki entry for RALA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALA Gene

Genomics for RALA Gene

Regulatory Elements for RALA Gene

Genomic Location for RALA Gene

Start:
39,623,483 bp from pter
End:
39,708,124 bp from pter
Size:
84,642 bases
Orientation:
Plus strand

Genomic View for RALA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RALA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALA Gene

Proteins for RALA Gene

  • Protein details for RALA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11233-RALA_HUMAN
    Recommended name:
    Ras-related protein Ral-A
    Protein Accession:
    P11233
    Secondary Accessions:
    • A4D1W3

    Protein attributes for RALA Gene

    Size:
    206 amino acids
    Molecular mass:
    23567 Da
    Quaternary structure:
    • Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1 mutually inhibit each others binding to LPAR1.

    Three dimensional structures from OCA and Proteopedia for RALA Gene

neXtProt entry for RALA Gene

Proteomics data for RALA Gene at MOPED

Post-translational modifications for RALA Gene

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • Ubiquitination at Lys159
  • Modification sites at PhosphoSitePlus

Other Protein References for RALA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RALA Gene

Domains for RALA Gene

Suggested Antigen Peptide Sequences for RALA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11233

UniProtKB/Swiss-Prot:

RALA_HUMAN :
  • P11233
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RALA: view

No data available for Gene Families for RALA Gene

Function for RALA Gene

Molecular function for RALA Gene

GENATLAS Biochemistry: simian leukemia viral (v-ral) oncogene homolog A,Ras oncogene superfamily member
UniProtKB/Swiss-Prot EnzymeRegulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
UniProtKB/Swiss-Prot Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
UniProtKB/Swiss-Prot Induction: Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2.

Gene Ontology (GO) - Molecular Function for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 10051605
GO:0005525 GTP binding IDA 24056301
GO:0017022 myosin binding IPI 24056301
GO:0019003 GDP binding IDA 24056301
genes like me logo Genes that share ontologies with RALA: view
genes like me logo Genes that share phenotypes with RALA: view

Animal Models for RALA Gene

MGI Knock Outs for RALA:

miRNA for RALA Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RALA Gene

Localization for RALA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALA Gene

Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RALA Gene COMPARTMENTS Subcellular localization image for RALA gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
endosome 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005886 plasma membrane IDA 17875936
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IDA 19306925
GO:0016020 membrane --
genes like me logo Genes that share ontologies with RALA: view

Pathways for RALA Gene

genes like me logo Genes that share pathways with RALA: view

Gene Ontology (GO) - Biological Process for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IDA 18756269
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0006887 exocytosis IEA --
GO:0006913 nucleocytoplasmic transport --
genes like me logo Genes that share ontologies with RALA: view

Compounds for RALA Gene

(1) Drugbank Compounds for RALA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target

(11) Novoseek inferred chemical compound relationships for RALA Gene

Compound -log(P) Hits PubMed IDs
gdp 66.6 13
gtp 64.9 14
geranylgeranyl pyrophosphate 48.1 2
guanine 29.9 2
phosphatidylinositol 18.4 3
genes like me logo Genes that share compounds with RALA: view

Transcripts for RALA Gene

Unigene Clusters for RALA Gene

V-ral simian leukemia viral oncogene homolog A (ras related):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RALA Gene

No ASD Table

Relevant External Links for RALA Gene

GeneLoc Exon Structure for
RALA
ECgene alternative splicing isoforms for
RALA

Expression for RALA Gene

mRNA expression in normal human tissues for RALA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RALA Gene

SOURCE GeneReport for Unigene cluster for RALA Gene Hs.6906

genes like me logo Genes that share expressions with RALA: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RALA Gene

Orthologs for RALA Gene

This gene was present in the common ancestor of animals.

Orthologs for RALA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALA 35
  • 99.68 (n)
  • 100 (a)
RALA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RALA 35
  • 91.91 (n)
  • 99.03 (a)
RALA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RALA 35
  • 95.63 (n)
  • 99.03 (a)
RALA 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rala 35
  • 92.72 (n)
  • 99.51 (a)
Rala 16
Rala 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RALA 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALA 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rala 35
  • 93.53 (n)
  • 99.51 (a)
chicken
(Gallus gallus)
Aves RALA 35
  • 86.73 (n)
  • 98.54 (a)
RALA 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RALA 36
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.663 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rala 35
  • 84.14 (n)
  • 98.06 (a)
Str.15001 35
zebrafish
(Danio rerio)
Actinopterygii ralaa 35
  • 78.48 (n)
  • 95.63 (a)
ralaa 36
  • 96 (a)
OneToMany
ralab 36
  • 94 (a)
OneToMany
zgc64038 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012108 35
  • 67.7 (n)
  • 80.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rala 35
  • 70.33 (n)
  • 83.52 (a)
Rala 36
  • 77 (a)
OneToMany
Rala 37
  • 79 (a)
worm
(Caenorhabditis elegans)
Secernentea ral-1 35
  • 60.84 (n)
  • 67.48 (a)
ral-1 36
  • 54 (a)
OneToMany
Y53G8AR.3 37
  • 77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10753 36
  • 66 (a)
OneToMany
Species with no ortholog for RALA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALA Gene

ENSEMBL:
Gene Tree for RALA (if available)
TreeFam:
Gene Tree for RALA (if available)

Paralogs for RALA Gene

Paralogs for RALA Gene

Pseudogenes.org Pseudogenes for RALA Gene

genes like me logo Genes that share paralogs with RALA: view

Variants for RALA Gene

Sequence variations from dbSNP and Humsavar for RALA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs917077 -- 39,636,437(-) TATCC(C/T)AGCAG intron-variant
rs1034771 -- 39,681,144(-) TGCAT(A/G)ACAAT intron-variant
rs1859480 -- 39,668,235(-) TAACT(A/G)TGCTA intron-variant
rs2008819 -- 39,622,669(-) AGAAT(A/G)GATAG upstream-variant-2KB
rs2066892 -- 39,676,873(-) TACCA(C/T)ACACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RALA Gene

Variant ID Type Subtype PubMed ID
nsv887970 CNV Loss 21882294
nsv508451 CNV Loss 20534489
dgv7251n71 CNV Gain 21882294

Relevant External Links for RALA Gene

HapMap Linkage Disequilibrium report
RALA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALA Gene

Disorders for RALA Gene

(1) University of Copenhagen DISEASES for RALA Gene

(10) Novoseek inferred disease relationships for RALA Gene

Disease -log(P) Hits PubMed IDs
bladder carcinoma 22 1
pancreatic carcinoma 18.8 2
cancer 14.9 11
bladder cancer 12.7 8
prostate carcinoma 8.95 1

Relevant External Links for RALA

Genetic Association Database (GAD)
RALA
Human Genome Epidemiology (HuGE) Navigator
RALA
genes like me logo Genes that share disorders with RALA: view

No data available for UniProtKB/Swiss-Prot for RALA Gene

Publications for RALA Gene

  1. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PMID: 14525976) Moskalenko S. … White M.A. (J. Biol. Chem. 2003) 3 4 23
  2. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PMID: 17875936) Falsetti S.C. … Sebti S.M. (Mol. Cell. Biol. 2007) 3 4 23
  3. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PMID: 18756269) Cascone I. … Camonis J. (EMBO J. 2008) 3 4 23
  4. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh A.I. … Bhattacharya M. (Cell. Signal. 2009) 3 4 23
  5. RalA suppresses early stages of Ras-induced squamous cell carcinoma progression. (PMID: 19802010) Sowalsky A.G. … Feig L.A. (Oncogene 2010) 3 23

Products for RALA Gene

  • Addgene plasmids for RALA

Sources for RALA Gene

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