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Aliases for RALA Gene

Aliases for RALA Gene

  • RAS Like Proto-Oncogene A 2 3 5
  • V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related) 2 3
  • Ras Family Small GTP Binding Protein RALA 2 3
  • Ras Related GTP Binding Protein A 2 3
  • Ras-Related Protein Ral-A 2 3
  • RAS-Like Protein A 2 3
  • RAL 3 4
  • RALA Ras Like Proto-Oncogene A 3

External Ids for RALA Gene

Previous HGNC Symbols for RALA Gene

  • RAL

Previous GeneCards Identifiers for RALA Gene

  • GC07P039372
  • GC07P039403
  • GC07P039436
  • GC07P039630
  • GC07P039547

Summaries for RALA Gene

Entrez Gene Summary for RALA Gene

  • The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for RALA Gene

RALA (RAS Like Proto-Oncogene A) is a Protein Coding gene. Diseases associated with RALA include Pancreatic Cancer. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include GTP binding and ubiquitin protein ligase binding. An important paralog of this gene is RALB.

UniProtKB/Swiss-Prot for RALA Gene

  • Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Gene Wiki entry for RALA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RALA Gene

Genomics for RALA Gene

Regulatory Elements for RALA Gene

Enhancers for RALA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G039588 1.9 FANTOM5 Ensembl ENCODE dbSUPER 22.6 -33.2 -33155 3.3 PKNOX1 FOXA2 ARNT FEZF1 ZNF766 CBX5 ZNF207 FOS JUNB REST RALA LOC105375240 YAE1D1 LINC00265 GC07P039582 GC07P039609
GH07G039732 1.7 FANTOM5 Ensembl ENCODE 13.9 +111.2 111241 3.8 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF207 ZNF143 FOS SP3 LINC00265 RALA YAE1D1 LOC105375240 CDK13 RNU6-719P
GH07G039604 1.2 FANTOM5 ENCODE dbSUPER 12.1 -17.6 -17556 2.5 JUND GATA2 NR2F1 STAT2 IRF1 NR2F2 ZKSCAN1 RALA YAE1D1 LOC105375240 GC07P039609 GC07P039582
GH07G039591 1.6 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -30.0 -30031 1.9 FOSL1 NFIC RAD51 JUND ATF3 JUN ZNF26 FOS TBX21 MPLKIP LINC00265 RALA GC07P039582 GC07P039609
GH07G039580 1.2 Ensembl ENCODE 11.8 -42.4 -42355 0.8 FOXA2 MLX CREB3L1 WRNIP1 ARID4B DMAP1 ZNF143 KLF13 DEK REST RALA LINC00265 GC07P039582 LOC100101126
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RALA on UCSC Golden Path with GeneCards custom track

Promoters for RALA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211206 1045 2401 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 YY1 ZNF143

Genomic Location for RALA Gene

Chromosome:
7
Start:
39,622,955 bp from pter
End:
39,708,124 bp from pter
Size:
85,170 bases
Orientation:
Plus strand

Genomic View for RALA Gene

Genes around RALA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RALA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RALA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RALA Gene

Proteins for RALA Gene

  • Protein details for RALA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11233-RALA_HUMAN
    Recommended name:
    Ras-related protein Ral-A
    Protein Accession:
    P11233
    Secondary Accessions:
    • A4D1W3

    Protein attributes for RALA Gene

    Size:
    206 amino acids
    Molecular mass:
    23567 Da
    Quaternary structure:
    • Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with GRK2 in response to LPAR1 activation. RALA and GRK2 mutually inhibit each others binding to LPAR1.

    Three dimensional structures from OCA and Proteopedia for RALA Gene

neXtProt entry for RALA Gene

Post-translational modifications for RALA Gene

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and farnesyltransferase I inhibitors (FTIs).
  • Ubiquitination at isoforms=159
  • Modification sites at PhosphoSitePlus

Other Protein References for RALA Gene

No data available for DME Specific Peptides for RALA Gene

Domains & Families for RALA Gene

Gene Families for RALA Gene

Suggested Antigen Peptide Sequences for RALA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11233

UniProtKB/Swiss-Prot:

RALA_HUMAN :
  • Belongs to the small GTPase superfamily. Ras family.
Family:
  • Belongs to the small GTPase superfamily. Ras family.
genes like me logo Genes that share domains with RALA: view

Function for RALA Gene

Molecular function for RALA Gene

GENATLAS Biochemistry:
simian leukemia viral (v-ral) oncogene homolog A,Ras oncogene superfamily member
UniProtKB/Swiss-Prot EnzymeRegulation:
Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
UniProtKB/Swiss-Prot Function:
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
UniProtKB/Swiss-Prot Induction:
Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2.

Gene Ontology (GO) - Molecular Function for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 7673236
GO:0005525 GTP binding IEA,IDA 24056301
GO:0017022 myosin binding IPI 24056301
GO:0019003 GDP binding IDA 24056301
genes like me logo Genes that share ontologies with RALA: view
genes like me logo Genes that share phenotypes with RALA: view

Animal Models for RALA Gene

MGI Knock Outs for RALA:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RALA
  • Applied Biological Materials Clones for RALA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RALA Gene

Localization for RALA Gene

Subcellular locations from UniProtKB/Swiss-Prot for RALA Gene

Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody. Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RALA gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 3
cytoskeleton 2
nucleus 2
endosome 2

Gene Ontology (GO) - Cellular Components for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IEA,IDA 17875936
GO:0005925 focal adhesion IDA 21423176
GO:0009986 cell surface IEA,IDA 19306925
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RALA: view

Pathways & Interactions for RALA Gene

genes like me logo Genes that share pathways with RALA: view

SIGNOR curated interactions for RALA Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for RALA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis IDA 18756269
GO:0001843 neural tube closure IEA --
GO:0006887 exocytosis IEA --
GO:0006935 chemotaxis TAS 10848592
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with RALA: view

Drugs & Compounds for RALA Gene

(6) Drugs for RALA Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0

(6) Additional Compounds for RALA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RALA: view

Transcripts for RALA Gene

Unigene Clusters for RALA Gene

V-ral simian leukemia viral oncogene homolog A (ras related):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RALA
  • Applied Biological Materials Clones for RALA

Alternative Splicing Database (ASD) splice patterns (SP) for RALA Gene

No ASD Table

Relevant External Links for RALA Gene

GeneLoc Exon Structure for
RALA
ECgene alternative splicing isoforms for
RALA

Expression for RALA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RALA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RALA Gene

This gene is overexpressed in Bone (9.3), Brain (6.8), and Frontal cortex (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RALA Gene



Protein tissue co-expression partners for RALA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RALA Gene:

RALA

SOURCE GeneReport for Unigene cluster for RALA Gene:

Hs.6906

Evidence on tissue expression from TISSUES for RALA Gene

  • Blood(4.6)
  • Lung(4.4)
  • Eye(4.2)
  • Nervous system(4.1)
  • Heart(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RALA: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RALA Gene

Orthologs for RALA Gene

This gene was present in the common ancestor of animals.

Orthologs for RALA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RALA 34 35
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia RALA 34 35
  • 95.63 (n)
rat
(Rattus norvegicus)
Mammalia Rala 34
  • 93.53 (n)
mouse
(Mus musculus)
Mammalia Rala 34 16 35
  • 92.72 (n)
cow
(Bos Taurus)
Mammalia RALA 34 35
  • 91.91 (n)
oppossum
(Monodelphis domestica)
Mammalia RALA 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RALA 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RALA 34 35
  • 86.73 (n)
lizard
(Anolis carolinensis)
Reptilia RALA 35
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rala 34
  • 84.14 (n)
Str.15001 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.663 34
zebrafish
(Danio rerio)
Actinopterygii ralab 35
  • 94 (a)
OneToMany
ralaa 34 35
  • 78.48 (n)
zgc64038 34
fruit fly
(Drosophila melanogaster)
Insecta Rala 36 34 35
  • 70.33 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012108 34
  • 67.7 (n)
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.3 36
  • 77 (a)
ral-1 34 35
  • 60.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10753 35
  • 66 (a)
OneToMany
Species where no ortholog for RALA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RALA Gene

ENSEMBL:
Gene Tree for RALA (if available)
TreeFam:
Gene Tree for RALA (if available)

Paralogs for RALA Gene

Paralogs for RALA Gene

Pseudogenes.org Pseudogenes for RALA Gene

genes like me logo Genes that share paralogs with RALA: view

Variants for RALA Gene

Sequence variations from dbSNP and Humsavar for RALA Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000004013 -- 39,708,231(+) GACTT(C/T)TTTTG downstream-variant-500B
rs1000061975 -- 39,660,407(+) AACAC(C/T)TATAA intron-variant
rs1000139999 -- 39,639,501(+) AGTGC(A/G)TTATG intron-variant
rs1000177514 -- 39,699,382(+) TGATC(C/G)ACCCG intron-variant
rs1000196028 -- 39,623,913(+) CCGAG(G/T)CCCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RALA Gene

Variant ID Type Subtype PubMed ID
nsv508451 CNV deletion 20534489

Variation tolerance for RALA Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RALA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RALA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RALA Gene

Disorders for RALA Gene

MalaCards: The human disease database

(1) MalaCards diseases for RALA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search RALA in MalaCards View complete list of genes associated with diseases

Relevant External Links for RALA

Genetic Association Database (GAD)
RALA
Human Genome Epidemiology (HuGE) Navigator
RALA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RALA
genes like me logo Genes that share disorders with RALA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RALA Gene

Publications for RALA Gene

  1. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PMID: 19306925) Aziziyeh A.I. … Bhattacharya M. (Cell. Signal. 2009) 3 4 22 64
  2. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PMID: 18756269) Cascone I. … Camonis J. (EMBO J. 2008) 3 4 22 64
  3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PMID: 17875936) Falsetti S.C. … Sebti S.M. (Mol. Cell. Biol. 2007) 3 4 22 64
  4. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PMID: 14525976) Moskalenko S. … White M.A. (J. Biol. Chem. 2003) 3 4 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for RALA Gene

  • Addgene plasmids for RALA

Sources for RALA Gene

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