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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RALA Gene

protein-coding   GIFtS: 68
GCID: GC07P039663

V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)


(Previous symbol: RAL)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)1 2
RAL1 2 3
Ras Family Small GTP Binding Protein RALA1 2
Ras Related GTP Binding Protein A1 2
RAS-Like Protein A1 2
Ras-Related Protein Ral-A1 2

External Ids:    HGNC: 98391   Entrez Gene: 58982   Ensembl: ENSG000000064517   OMIM: 1795505   UniProtKB: P112333   

Export aliases for RALA gene to outside databases

Previous GC identifers: GC07P039372 GC07P039403 GC07P039436 GC07P039630 GC07P039547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RALA Gene:
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins
mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene
encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras
proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for RALA Gene: 
RALA (v-ral simian leukemia viral oncogene homolog A (ras related)) is a protein-coding gene. Diseases associated with RALA include clostridium sordellii, and anisakiasis, and among its related super-pathways are Signalling to RAS and NGF signalling via TRKA from the plasma membrane. GO annotations related to this gene include Edg-2 lysophosphatidic acid receptor binding and GTP binding. An important paralog of this gene is RAP2C.

UniProtKB/Swiss-Prot: RALA_HUMAN, P11233
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the
cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth
signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the
signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells

Gene Wiki entry for RALA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RALA gene promoter:
         p53   AP-1   FOXO4   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RALA promoter sequence
   Search SABiosciences Chromatin IP Primers for RALA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RALA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p22-p15

RALA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039663:  view genomic region     (about GC identifiers)

Start:
39,663,082 bp from pter      End:
39,747,723 bp from pter
Size:
84,642 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,701,014-39,785,596     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RALA_HUMAN, P11233 (See protein sequence)
Recommended Name: Ras-related protein Ral-A precursor  
Size: 206 amino acids; 23567 Da
Subunit: Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have
overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with
RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1
mutually inhibit each other's binding to LPAR1
Subcellular location: Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody.
Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA co-localizes with
LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane.
Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody
6 PDB 3D structures from and Proteopedia for RALA:
1UAD (3D)        1ZC3 (3D)        1ZC4 (3D)        2A78 (3D)        2A9K (3D)        2BOV (3D)    
Secondary accessions: A4D1W3

Explore the universe of human proteins at neXtProt for RALA: NX_P11233

Explore proteomics data for RALA at MOPED 

Post-translational modifications:

  • UniProtKB: Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does
    not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and
    farnesyltransferase I inhibitors (FTIs)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11233

  • RALA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RALA Protein Expression
    REFSEQ proteins: NP_005393.2  
    ENSEMBL proteins: 
     ENSP00000005257   ENSP00000388975   ENSP00000413227  
    Reactome Protein details: P11233
    Human Recombinant Protein Products for RALA: 
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    Novus Biologicals RALA Proteins
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for RALA
    Cloud-Clone Corp. Proteins for RALA 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IDA17875936
    GO:0009986cell surface IDA19306925
    GO:0016020membrane ----
    GO:0030139colocalizes with endocytic vesicle IDA19306925

    RALA for ontologies           About GeneDecksing



    RALA Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P11233

    ProtoNet protein and cluster: P11233

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RALA_HUMAN, P11233
    Similarity: Belongs to the small GTPase superfamily. Ras family


    RALA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RALA_HUMAN, P11233
    Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
    migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
    functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
    dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the
    cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth
    signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the
    signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells
    Enzyme regulation: Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a
    guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
    Induction: Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2

         Genatlas biochemistry entry for RALA:
    simian leukemia viral (v-ral) oncogene homolog A,Ras oncogene superfamily member

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0031755Edg-2 lysophosphatidic acid receptor binding IDA19306925
         
    RALA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RALA:
     Altered focal adhesion (FA) or 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rala):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     tumorigenesis 

    RALA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ralatm1.1Cjm for RALA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RALA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RALA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALA 
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    SwitchGear 3'UTR luciferase reporter plasmidRALA 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RALA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RALA About   (see all 20)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signalling to RAS
    Signalling to RAS0.73
    p38MAPK events0.48
    Signalling to ERKs0.73
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    3Membrane Trafficking
    Translocation of GLUT4 to the Plasma Membrane0.32
    Membrane Trafficking0.32
    4GPCR Pathway
    Ras Pathway0.73
    5Akt Signaling
    p38 Signaling0.60

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for RALA
        Cytoskeleton remodeling RalA regulation pathway
    G-protein signaling Cross-talk between Ras-family GTPases

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RALA (see all 7)
        Remodeling of Adherens Junctions
    FGF Pathway
    Molecular Mechanisms of Cancer
    CDC42 Pathway
    p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for RALA
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for RALA
        G-protein signaling Cross-talk between Ras-family GTPases
    Cytoskeleton remodeling RalA regulation pathway

    4 BioSystems Pathways for RALA
        Integrated Breast Cancer Pathway
    RalA downstream regulated genes
    ErbB1 downstream signaling
    Arf6 trafficking events

    5/8        Reactome Pathways for RALA (see all 8)
        p38MAPK events
    Membrane Trafficking
    Signal Transduction
    Signalling to RAS
    Translocation of GLUT4 to the Plasma Membrane


    2         Kegg Pathways  (Kegg details for RALA):
        Pathways in cancer
    Pancreatic cancer


    RALA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RALA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for RALA (P112331, 2, 3 ENSP000000052574) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-15764 MINT-15765 MINT-15766 I2D: score=4 
    CALM3P621582, 3MINT-15764 MINT-15765 MINT-15766 I2D: score=4 
    PPP2CBP627142, 3, ENSP000002211384MINT-8208450 MINT-8208475 MINT-8208457 I2D: score=1 STRING: ENSP00000221138
    PPP2R1BP301541, 3, ENSP000003113444EBI-1036803,EBI-357094 I2D: score=3 STRING: ENSP00000311344
    HRASP011122, 3, ENSP000003098454MINT-6946532 I2D: score=2 STRING: ENSP00000309845
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IDA18756269
    GO:0006184GTP catabolic process ----
    GO:0006886intracellular protein transport ----
    GO:0006887exocytosis IEA--
    GO:0006913nucleocytoplasmic transport ----

    RALA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RALA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RALA

    1 DrugBank Compound for RALA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    10/11 Novoseek inferred chemical compound relationships for RALA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 66.6 23 8702675 (3), 9053849 (2), 1379346 (1), 8524240 (1) (see all 10)
    gtp 64.9 23 17202486 (4), 11322487 (3), 8702675 (2), 1379346 (1) (see all 8)
    geranylgeranyl pyrophosphate 48.1 3 8972729 (1), 16125679 (1)
    guanine 29.9 3 10851075 (1), 19567266 (1)
    phosphatidylinositol 18.4 3 15263068 (1), 10419502 (1), 15208305 (1)
    tyrosine 2.82 3 12866021 (1), 9550702 (1), 7477381 (1)
    calcium 0.735 29 11322487 (4), 12034722 (4), 9566869 (2), 10419502 (1) (see all 5)
    tamoxifen 0.656 1 10896938 (1)
    oxygen 0 1 16964283 (1)
    phospholipid 0 2 15980073 (1)

    Search CenterWatch for drugs/clinical trials and news about RALA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RALA gene: 
    NM_005402.3  

    Unigene Cluster for RALA:

    V-ral simian leukemia viral oncogene homolog A (ras related)
    Hs.6906  [show with all ESTs]
    Unigene Representative Sequence: NM_005402
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005257(uc003thd.3) ENST00000468201 ENST00000436179 ENST00000434466
    ENST00000466491
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF086082.1 AF493910.1 AK026850.1 AK308109.1 BC039858.1 M29893.1 X15014.1 

    14 DOTS entries:

    DT.80100564  DT.100785246  DT.95294309  DT.100656840  DT.91757843  DT.100785247  DT.121073355  DT.121073398 
    DT.95294307  DT.95294311  DT.121073387  DT.91757845  DT.95294310  DT.95294312 

    24/275 AceView cDNA sequences (see all 275):

    BU630853 F10427 BM821639 AI359218 AI304637 AA634813 BM505011 BM806998 
    X15014 BM846242 BM728216 AA382990 BI770485 F10291 AI214200 AW515487 
    F11825 CA444080 Z45627 AI344679 BM550259 AW474027 AA379902 BU743277 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RALA expression in normal human tissues (normalized intensities)      RALA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACTTATT
    RALA Expression
    About this image


    RALA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Larynx (Respiratory System)

    See RALA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RALA

    SOURCE GeneReport for Unigene cluster: Hs.6906
        SABiosciences Expression via Pathway-Focused PCR Arrays including RALA: 
              Estrogen Receptor Signaling in human mouse rat
              Adherens Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RALA gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rala1 , 5 v-ral simian leukemia viral oncogene homolog A (ras more1, 5 92.72(n)1
    99.51(a)1
      13 (6.05 cM)5
    560441  NM_019491.51  NP_062364.31 
     178805755 
    chicken
    (Gallus gallus)
    Aves RALA1 v-ral simian leukemia viral oncogene homolog A (ras more 86.73(n)
    98.54(a)
      420765  XM_418863.3  XP_418863.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALA6
    v-ral simian leukemia viral oncogene homolog A (ra...
    99(a)
    1 ↔ 1
    6(48833014-48848806)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6632 Xenopus laevis Ras related small G protein RAL-A mRNA, more 82.61(n)    AF278539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640382 similar to v-ral simian leukemia viral oncogene homolog more 79.52(n)   393993  BC053216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rala1 , 3 dorsal closure RAS small monomeric
    GTPase3
    Ras-related protein1
    79(a)3
    68.58(n)1
    80.73(a)1
      3E53
    313321  NM_080324.31  NP_525063.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y53G8AR.33
    ral-11
    Protein RAL-11 77(a)3
    62.21(n)1
    70.3(a)1
      III(3384386-3389320)3
    1754331  NM_065288.51  NP_497689.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAS16
    RAS26
    GTPase involved in G-protein signaling in the aden...
    GTP-binding protein that regulates the nitrogen st...
    29(a)
    28(a)
    many ↔ many
    many ↔ many
    XV(515244-516173)
    XIV(439602-440570)


    ENSEMBL Gene Tree for RALA (if available)
    TreeFam Gene Tree for RALA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RALA gene
    RAP2C2  DIRAS12  RAP1B2  RIT22  RAP2A2  RIT12  RALB2  RAP1A2  
    RAP2B2  NRAS2  DIRAS22  KRAS2  HRAS2  DIRAS32  
    18/105 SIMAP similar genes for RALA using alignment to 3 protein entries:     RALA_HUMAN (see all proteins) (see all similar genes):
    K-RAS    RALB    N-ras    KRAS    c-bas/has    NRAS
    HRAS    RAP1B    RAP1A    RIT2    DKFZp547A0616    RAP2B
    RAP2A    RAP2C    RIT1    RRAS    RRAS2    RERG

    RALA for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RALA
    PGOHUM00000239525 PGOHUM00000233143


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1475 SNPs in RALA are shown (see all 1475)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715601331,2
    C--39643391(+) TAACT-/AC/   
      ACACAC
    ACACA
    1 -- int11NA 2
    rs1150911051,2
    C--39661222(+) CAGAAC/TAAAAA 1 -- us2k10--------
    rs768890661,2
    C--39661238(+) AAAATA/TAAAAT 1 -- us2k10--------
    rs753047121,2
    C--39661325(+) TCCAGT/CTTCTG 1 -- us2k12Minor allele frequency- C:0.10CSA WA 120
    rs1444505821,2
    --39661409(+) CCATAC/TTGGGT 1 -- us2k10--------
    rs1882909741,2
    --39661437(+) CAGTAA/GTTTTC 1 -- us2k10--------
    rs350148201,2
    C--39661473(+) AGTGGT/-TTTTG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1464508691,2
    --39661506(+) ACTGCA/CGTCAG 1 -- us2k10--------
    rs102545621,2
    C,F,A,H--39661524(+) ATGGTC/AATCTA 1 -- us2k124Minor allele frequency- A:0.40NS EA NA WA CSA 2532
    rs1922721441,2
    --39661715(+) AAATAC/TACCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALA (39663082 - 39747723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RALA:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508451CNV Loss20534489
    nsv887970CNV Loss21882294
    dgv7251n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 179550    OMIM disorders: --

    20/26 diseases for RALA (see all 26):    About MalaCards
    clostridium sordellii    anisakiasis    intestinal volvulus    clostridium difficile
    tuberous sclerosis complex    bladder carcinoma    tuberous sclerosis    pheochromocytoma
    fibrosarcoma    leukemia    pancreatitis    pancreatic cancer
    chronic myeloid leukemia    periodontitis    multiple myeloma    myeloma
    prostatitis    retinitis    myeloid leukemia    alzheimer's disease

    1 disease from the University of Copenhagen DISEASES database for RALA:
    Osteoporosis

    RALA for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10 Novoseek inferred disease relationships for RALA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder carcinoma 22 1 16488989 (1)
    pancreatic carcinoma 18.8 2 17174914 (1), 16757353 (1)
    cancer 14.9 12 16103060 (3), 15953551 (1), 17875936 (1), 17496927 (1) (see all 9)
    bladder cancer 12.7 12 17606711 (6), 17496927 (2)
    prostate carcinoma 8.95 1 16964283 (1)
    pheochromocytoma 6.63 3 17202486 (1), 17344481 (1)
    breast cancer 0 2 12386818 (1), 10896938 (1)
    metastasis 0 4 17174914 (1), 17606711 (1), 16103060 (1)
    tumors 0 16 10467419 (2), 17174914 (1), 17606711 (1), 17875936 (1) (see all 9)
    pancreatic cancer 0 5 17174914 (3), 15950903 (1)

    Genetic Association Database (GAD): RALA
    Human Genome Epidemiology (HuGE) Navigator: RALA (1 document)

    Export disorders for RALA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RALA gene, integrated from 9 sources (see all 184):
    (articles sorted by number of sources associating them with RALA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)1, 2, 9 Moskalenko S.... White M.A. (2003)
    2. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2, 9 Aziziyeh A.I....Bhattacharya M. (2009)
    3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PubMed id 17875936)1, 2, 9 Falsetti S.C.... Sebti S.M. (2007)
    4. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PubMed id 18756269)1, 2, 9 Cascone I.... Camonis J. (2008)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase. (PubMed id 15809419)1, 2 Holbourn K.P.... Acharya K.R. (2005)
    7. Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. (PubMed id 15920473)1, 2 Jin R....Brunger A.T. (2005)
    8. Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. (PubMed id 16177825)1, 2 Pautsch A.... Aktories K. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5898 HGNC: 9839 AceView: RALA Ensembl:ENSG00000006451 euGenes: HUgn5898
    ECgene: RALA Kegg: 5898 H-InvDB: RALA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RALA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RALA gene:
    Search GeneIP for patents involving RALA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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