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RALA Gene

protein-coding   GIFtS: 69
GCID: GC07P039663

V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)


(Previous symbol: RAL)
  Search for RALA
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
V-Ral Simian Leukemia Viral Oncogene Homolog A (Ras Related)1 2
RAL1 2 3
Ras Family Small GTP Binding Protein RALA1 2
Ras Related GTP Binding Protein A1 2
RAS-Like Protein A1 2
Ras-Related Protein Ral-A1 2

External Ids:    HGNC: 98391   Entrez Gene: 58982   Ensembl: ENSG000000064517   OMIM: 1795505   UniProtKB: P112333   

Export aliases for RALA gene to outside databases

Previous GC identifers: GC07P039372 GC07P039403 GC07P039436 GC07P039630 GC07P039547


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RALA Gene:
The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins
mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene
encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras
proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for RALA Gene:
RALA (v-ral simian leukemia viral oncogene homolog A (ras related)) is a protein-coding gene. GO annotations related to this gene include Edg-2 lysophosphatidic acid receptor binding and GTP binding. An important paralog of this gene is REM1.

UniProtKB/Swiss-Prot: RALA_HUMAN, P11233
Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the
cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth
signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the
signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells

Gene Wiki entry for RALA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RALA gene promoter:
         p53   AP-1   FOXO4   ATF-2   c-Jun   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RALA promoter sequence
   Search Chromatin IP Primers for RALA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RALA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p15-p13   Ensembl cytogenetic band:  7p14.1   HGNC cytogenetic band: 7p22-p15

RALA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RALA gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P039663:  view genomic region     (about GC identifiers)

Start:
39,663,082 bp from pter      End:
39,747,723 bp from pter
Size:
84,642 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 39,701,014-39,785,596     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RALA_HUMAN, P11233 (See protein sequence)
Recommended Name: Ras-related protein Ral-A precursor  
Size: 206 amino acids; 23567 Da
Subunit: Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have
overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with
RALGPS1. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1
mutually inhibit each other's binding to LPAR1
6 PDB 3D structures from and Proteopedia for RALA:
1UAD (3D)        1ZC3 (3D)        1ZC4 (3D)        2A78 (3D)        2A9K (3D)        2BOV (3D)    
Secondary accessions: A4D1W3

Explore the universe of human proteins at neXtProt for RALA: NX_P11233

Explore proteomics data for RALA at MOPED

Post-translational modifications: 

  • Prenylation is essential for membrane localization. The geranylgeranylated form and the farnesylated mutant does
    not undergo alternative prenylation in response to geranylgeranyltransferase I inhibitors (GGTIs) and
    farnesyltransferase I inhibitors (FTIs)1
  • Ubiquitination2 at Lys159
  • Modification sites at PhosphoSitePlus

  • See RALA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005393.2  
    ENSEMBL proteins: 
     ENSP00000005257   ENSP00000388975   ENSP00000413227  
    Reactome Protein details: P11233

    RALA Human Recombinant Protein Products:

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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RALA
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    Search eBioscience for ELISAs for RALA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR028412 Ral
     IPR005225 Small_GTP-bd_dom
     IPR001806 Small_GTPase
     IPR027417 P-loop_NTPase
     IPR020849 Small_GTPase_Ras

    Graphical View of Domain Structure for InterPro Entry P11233

    ProtoNet protein and cluster: P11233

    2 Blocks protein domains:
    IPB001806 Transforming protein P21 RAS signature
    IPB003577 Ras small GTPase


    UniProtKB/Swiss-Prot: RALA_HUMAN, P11233
    Similarity: Belongs to the small GTPase superfamily. Ras family


    Find genes that share domains with RALA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RALA_HUMAN, P11233
    Function: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell
    migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple
    functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of
    dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the
    cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth
    signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the
    signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells
    Enzyme regulation: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by
    a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP)
    Induction: Activated in an LPA-dependent manner by LPAR1 and in an LPA-independent manner by LPAR2

         Genatlas biochemistry entry for RALA:
    simian leukemia viral (v-ral) oncogene homolog A,Ras oncogene superfamily member

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity ----
    GO:0005515protein binding IPI10051605
    GO:0005525GTP binding IEA--
    GO:0031755Edg-2 lysophosphatidic acid receptor binding IDA19306925
         
    Find genes that share ontologies with RALA           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RALA:
     Altered focal adhesion (FA) or 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rala):
     cellular  embryogenesis  growth/size/body  mortality/aging  nervous system 
     tumorigenesis 

    Find genes that share phenotypes with RALA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ralatm1.1Cjm for RALA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RALA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RALA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RALA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RALA

    miRNA
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    miRTarBase miRNAs that target RALA:
    hsa-mir-186-5p (MIRT045096), hsa-mir-24-3p (MIRT030612), hsa-mir-7-5p (MIRT047767), hsa-mir-181a-5p (MIRT006194)

    Block miRNA regulation of human, mouse, rat RALA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RALA (see all 27):
    hsa-miR-140-5p hsa-miR-3910 hsa-miR-548j hsa-miR-34b* hsa-miR-181c hsa-miR-548i hsa-miR-205* hsa-miR-330-3p
    SwitchGear 3'UTR luciferase reporter plasmidRALA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RALA

    Gene Editing
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    Addgene plasmids for RALA 

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    eBioscience FlowRNA Probe Sets ( VA1-11276) for RALA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RALA_HUMAN, P11233: Cell surface. Cell membrane; Lipid-anchor; Cytoplasmic side. Cleavage furrow. Midbody.
    Note=Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA colocalizes with
    LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane.
    Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    cytoskeleton2
    nucleus2
    endosome1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane IDA17875936
    GO:0009986cell surface IDA19306925
    GO:0016020membrane ----
    GO:0030139colocalizes with endocytic vesicle IDA19306925

    Find genes that share ontologies with RALA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RALA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1Signalling to ERKs
    Signalling to ERKs0.73
    p38MAPK events0.00
    Signalling to RAS0.73
    2Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    3Ras signaling pathway
    Rap1 signaling pathway0.36
    Ras signaling pathway0.36
    4Clathrin derived vesicle budding
    Membrane Trafficking0.32
    Translocation of GLUT4 to the Plasma Membrane0.32
    5GPCR Pathway
    Ras Pathway0.73


    Find genes that share SuperPaths with RALA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RALA (see all 7)
        Remodeling of Adherens Junctions
    FGF Pathway
    Molecular Mechanisms of Cancer
    CDC42 Pathway
    p38 Signaling

    1 Cell Signaling Technology (CST) Pathway for RALA
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for RALA
        G-protein signaling Cross-talk between Ras-family GTPases
    Cytoskeleton remodeling RalA regulation pathway

    4 BioSystems Pathways for RALA
        Integrated Breast Cancer Pathway
    RalA downstream regulated genes
    Arf6 trafficking events
    ErbB1 downstream signaling


    2 Reactome Pathways for RALA
        p38MAPK events
    Translocation of GLUT4 to the plasma membrane


    4 Kegg Pathways  (Kegg details for RALA):
        Ras signaling pathway
    Rap1 signaling pathway
    Pathways in cancer
    Pancreatic cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RALA: 
              Estrogen Receptor Signaling in human mouse rat
              Adherens Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RALA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RALA (P112331, 2, 3 ENSP000000052574) via UniProtKB, MINT, STRING, and/or I2D (see all 107)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-15764 MINT-15765 MINT-15766 I2D: score=4 
    CALM3P621582, 3MINT-15764 MINT-15765 MINT-15766 I2D: score=4 
    PPP2CBP627142, 3, ENSP000002211384MINT-8208450 MINT-8208475 MINT-8208457 I2D: score=1 STRING: ENSP00000221138
    PPP2R1BP301541, 3, ENSP000003113444EBI-1036803,EBI-357094 I2D: score=3 STRING: ENSP00000311344
    HRASP011122, 3, ENSP000003098454MINT-6946532 I2D: score=2 STRING: ENSP00000309845
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    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis IDA18756269
    GO:0006184GTP catabolic process IEA--
    GO:0006886intracellular protein transport ----
    GO:0006887exocytosis IEA--
    GO:0006913nucleocytoplasmic transport ----

    Find genes that share ontologies with RALA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RALA

    1 DrugBank Compound for RALA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    Selected Novoseek inferred chemical compound relationships for RALA gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 66.6 23 8702675 (3), 9053849 (2), 1379346 (1), 8524240 (1) (see all 10)
    gtp 64.9 23 17202486 (4), 11322487 (3), 8702675 (2), 1379346 (1) (see all 8)
    geranylgeranyl pyrophosphate 48.1 3 8972729 (1), 16125679 (1)
    guanine 29.9 3 10851075 (1), 19567266 (1)
    phosphatidylinositol 18.4 3 15263068 (1), 10419502 (1), 15208305 (1)
    tyrosine 2.82 3 12866021 (1), 9550702 (1), 7477381 (1)
    calcium 0.735 29 11322487 (4), 12034722 (4), 9566869 (2), 10419502 (1) (see all 5)
    tamoxifen 0.656 1 10896938 (1)
    oxygen 0 1 16964283 (1)
    phospholipid 0 2 15980073 (1)



    Find genes that share compounds with RALA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RALA gene: 
    NM_005402.3  

    Unigene Cluster for RALA:

    V-ral simian leukemia viral oncogene homolog A (ras related)
    Hs.6906  [show with all ESTs]
    Unigene Representative Sequence: NM_005402
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000005257(uc003thd.3) ENST00000468201 ENST00000436179 ENST00000434466
    ENST00000466491
    miRNA
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    hsa-miR-140-5p hsa-miR-3910 hsa-miR-548j hsa-miR-34b* hsa-miR-181c hsa-miR-548i hsa-miR-205* hsa-miR-330-3p
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    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RALA
    Addgene plasmids for RALA 
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    Additional mRNA sequence: 

    AF086082.1 AF493910.1 AK026850.1 AK308109.1 BC039858.1 M29893.1 X15014.1 

    14 DOTS entries:

    DT.80100564  DT.100785246  DT.95294309  DT.100656840  DT.91757843  DT.100785247  DT.121073355  DT.121073398 
    DT.95294307  DT.95294311  DT.121073387  DT.91757845  DT.95294310  DT.95294312 

    Selected AceView cDNA sequences (see all 275):

    AW474027 AI702525 BM505011 BQ068256 BQ000080 AW515483 BX282420 AI278917 
    BM821639 CA311969 BM992487 CA444080 BI770485 BF642801 AW515487 N62870 
    AI283900 AF086082 AI752992 AI344679 T33354 AA617801 Z45627 AA994756 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RALA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACTTATT
    RALA Expression
    About this image


    RALA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Bone (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Cartilage (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     Larynx (Respiratory System)
    RALA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RALA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6906
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RALA: 
              Estrogen Receptor Signaling in human mouse rat
              Adherens Junctions in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RALA gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rala1 , 5 v-ral simian leukemia viral oncogene homolog A (ras more1, 5 92.72(n)1
    99.51(a)1
      13 (6.05 cM)5
    560441  NM_019491.51  NP_062364.31 
     178805755 
    chicken
    (Gallus gallus)
    Aves RALA1 v-ral simian leukemia viral oncogene homolog A (ras more 86.73(n)
    98.54(a)
      420765  XM_004939564.1  XP_004939621.1 
    lizard
    (Anolis carolinensis)
    Reptilia RALA6
    v-ral simian leukemia viral oncogene homolog A (ra...
    99(a)
    1 ↔ 1
    6(48833014-48848806)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.6632 Xenopus laevis Ras related small G protein RAL-A mRNA, more 82.61(n)    AF278539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc640382 similar to v-ral simian leukemia viral oncogene homolog more 79.52(n)   393993  BC053216.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rala1 , 3 dorsal closure RAS small monomeric
    GTPase3
    Ras-related protein1
    79(a)3
    70.33(n)1
    83.52(a)1
      3E53
    313321  NM_166986.21  NP_726882.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y53G8AR.33
    ral-11
    ral-11 77(a)3
    60.84(n)1
    67.48(a)1
      III(3384386-3389320)3
    1754331  NM_001267937.11  NP_001254866.11 


    ENSEMBL Gene Tree for RALA (if available)
    TreeFam Gene Tree for RALA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RALA gene
    REM12  RRAS2  RALB2  ERAS2  RRAD2  NRAS2  REM22  KRAS2  
    GEM2  RRAS22  HRAS2  MRAS2  
    Selected SIMAP similar genes for RALA using alignment to 3 protein entries:     RALA_HUMAN (see all proteins) (see all similar genes):
    K-RAS    RALB    N-ras    KRAS    c-bas/has    NRAS
    HRAS    RAP1B    RAP1A    RIT2    DKFZp547A0616    RAP2B
    RAP2A    RAP2C    RIT1    RRAS    RRAS2    RERG

    Find genes that share paralogs with RALA           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for RALA
    PGOHUM00000239525 PGOHUM00000233143


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RALA (see all 1475)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715601331,2
    C--39643391(+) TAACT-/AC/   
      ACACAC
    ACACA
    1 -- int11NA 2
    rs1150911051,2
    C--39661222(+) CAGAAC/TAAAAA 1 -- us2k10--------
    rs768890661,2
    C--39661238(+) AAAATA/TAAAAT 1 -- us2k10--------
    rs753047121,2
    C--39661325(+) TCCAGT/CTTCTG 1 -- us2k12Minor allele frequency- C:0.10CSA WA 120
    rs1444505821,2
    --39661409(+) CCATAC/TTGGGT 1 -- us2k10--------
    rs1882909741,2
    --39661437(+) CAGTAA/GTTTTC 1 -- us2k10--------
    rs350148201,2
    C--39661473(+) AGTGGT/-TTTTG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1464508691,2
    --39661506(+) ACTGCA/CGTCAG 1 -- us2k10--------
    rs102545621,2
    C,F,A,H--39661524(+) ATGGTC/AATCTA 1 -- us2k124Minor allele frequency- A:0.40NS EA NA WA CSA 2532
    rs1922721441,2
    --39661715(+) AAATAC/TACCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RALA (39663082 - 39747723 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RALA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508451CNV Loss20534489
    nsv887970CNV Loss21882294
    dgv7251n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179550    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for RALA:
    Osteoporosis

    Find genes that share disorders with RALA           About GenesLikeMe

    10 Novoseek inferred disease relationships for RALA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bladder carcinoma 22 1 16488989 (1)
    pancreatic carcinoma 18.8 2 17174914 (1), 16757353 (1)
    cancer 14.9 12 16103060 (3), 15953551 (1), 17875936 (1), 17496927 (1) (see all 9)
    bladder cancer 12.7 12 17606711 (6), 17496927 (2)
    prostate carcinoma 8.95 1 16964283 (1)
    pheochromocytoma 6.63 3 17202486 (1), 17344481 (1)
    breast cancer 0 2 12386818 (1), 10896938 (1)
    metastasis 0 4 17174914 (1), 17606711 (1), 16103060 (1)
    tumors 0 16 10467419 (2), 17174914 (1), 17606711 (1), 17875936 (1) (see all 9)
    pancreatic cancer 0 5 17174914 (3), 15950903 (1)

    Genetic Association Database (GAD): RALA
    Human Genome Epidemiology (HuGE) Navigator: RALA (1 document)

    Export disorders for RALA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RALA gene, integrated from 10 sources (see all 187):
    (articles sorted by number of sources associating them with RALA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ral GTPases regulate exocyst assembly through dual subunit interactions. (PubMed id 14525976)1, 2, 9 Moskalenko S.... White M.A. (J. Biol. Chem. 2003)
    2. Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK. (PubMed id 19306925)1, 2, 9 Aziziyeh A.I.... Bhattacharya M. (Cell. Signal. 2009)
    3. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. (PubMed id 17875936)1, 2, 9 Falsetti S.C.... Sebti S.M. (Mol. Cell. Biol. 2007)
    4. Distinct roles of RalA and RalB in the progression of cytokinesis are supported by distinct RalGEFs. (PubMed id 18756269)1, 2, 9 Cascone I.... Camonis J. (EMBO J. 2008)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase. (PubMed id 15809419)1, 2 Holbourn K.P.... Acharya K.R. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    7. Exo84 and Sec5 are competitive regulatory Sec6/8 effectors to the RalA GTPase. (PubMed id 15920473)1, 2 Jin R....Brunger A.T. (EMBO J. 2005)
    8. Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. (PubMed id 16177825)1, 2 Pautsch A.... Aktories K. (EMBO J. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5898 HGNC: 9839 AceView: RALA Ensembl:ENSG00000006451 euGenes: HUgn5898
    ECgene: RALA Kegg: 5898 H-InvDB: RALA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RALA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RALA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RALA gene:
    Search GeneIP for patents involving RALA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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