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Aliases for RAI2 Gene

Aliases for RAI2 Gene

  • Retinoic Acid Induced 2 2 3 5

External Ids for RAI2 Gene

Previous GeneCards Identifiers for RAI2 Gene

  • GC0XM017362
  • GC0XM016484
  • GC0XM017020
  • GC0XM017179
  • GC0XM017578
  • GC0XM017728
  • GC0XM015576

Summaries for RAI2 Gene

Entrez Gene Summary for RAI2 Gene

  • Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for RAI2 Gene

RAI2 (Retinoic Acid Induced 2) is a Protein Coding gene. Diseases associated with RAI2 include nance-horan syndrome and fried syndrome.

Gene Wiki entry for RAI2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI2 Gene

Genomics for RAI2 Gene

Regulatory Elements for RAI2 Gene

Promoters for RAI2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAI2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAI2 Gene

17,800,049 bp from pter
17,861,346 bp from pter
61,298 bases
Minus strand

Genomic View for RAI2 Gene

Genes around RAI2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAI2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI2 Gene

Proteins for RAI2 Gene

  • Protein details for RAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoic acid-induced protein 2
    Protein Accession:
    Secondary Accessions:
    • B1B1K2
    • B4DQM9
    • E7EMN4
    • Q8N6X7

    Protein attributes for RAI2 Gene

    530 amino acids
    Molecular mass:
    57180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAI2 Gene


neXtProt entry for RAI2 Gene

Proteomics data for RAI2 Gene at MOPED

Post-translational modifications for RAI2 Gene

  • Ubiquitination at Lys 266
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAI2 (RAI2)

No data available for DME Specific Peptides for RAI2 Gene

Domains & Families for RAI2 Gene

Protein Domains for RAI2 Gene


Suggested Antigen Peptide Sequences for RAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAI2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RAI2 Gene

Function for RAI2 Gene

Molecular function for RAI2 Gene

GENATLAS Biochemistry:
retinoic acid induced 2,expressed in heart,brain,placenta,lung,skeletal muscle,kidney,pancreas and retina,excluded as causing-disease gene in Nance-Horan syndrome

Phenotypes for RAI2 Gene

GenomeRNAi human phenotypes for RAI2:
genes like me logo Genes that share phenotypes with RAI2: view

Animal Model Products

miRNA for RAI2 Gene

miRTarBase miRNAs that target RAI2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAI2 Gene

Localization for RAI2 Gene

Subcellular locations from

Jensen Localization Image for RAI2 Gene COMPARTMENTS Subcellular localization image for RAI2 gene
Compartment Confidence
cytosol 2
nucleus 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RAI2 Gene

Pathways & Interactions for RAI2 Gene

SuperPathways for RAI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAI2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RAI2 Gene

Drugs & Compounds for RAI2 Gene

No Compound Related Data Available

Transcripts for RAI2 Gene

Unigene Clusters for RAI2 Gene

Retinoic acid induced 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAI2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for RAI2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAI2 Gene

mRNA expression in normal human tissues for RAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAI2 Gene

SOURCE GeneReport for Unigene cluster for RAI2 Gene Hs.446680

genes like me logo Genes that share expression patterns with RAI2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RAI2 Gene

Orthologs for RAI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAI2 35
  • 86.11 (n)
  • 85.66 (a)
RAI2 36
  • 85 (a)
(Canis familiaris)
Mammalia RAI2 35
  • 87.81 (n)
  • 87.19 (a)
RAI2 36
  • 95 (a)
(Mus musculus)
Mammalia Rai2 35
  • 87.65 (n)
  • 89.98 (a)
Rai2 16
Rai2 36
  • 89 (a)
(Pan troglodytes)
Mammalia RAI2 35
  • 98.07 (n)
  • 97.1 (a)
RAI2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Rai2 35
  • 87.4 (n)
  • 90.93 (a)
(Monodelphis domestica)
Mammalia RAI2 36
  • 71 (a)
(Gallus gallus)
Aves RAI2 35
  • 68.91 (n)
  • 65.7 (a)
RAI2 36
  • 61 (a)
(Anolis carolinensis)
Reptilia RAI2 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rai2 35
  • 60.08 (n)
  • 58.37 (a)
(Danio rerio)
Actinopterygii LOC101885820 35
  • 50.32 (n)
  • 44.4 (a)
RAI2 36
  • 37 (a)
Species with no ortholog for RAI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI2 Gene

Gene Tree for RAI2 (if available)
Gene Tree for RAI2 (if available)

Paralogs for RAI2 Gene

No data available for Paralogs for RAI2 Gene

Variants for RAI2 Gene

Sequence variations from dbSNP and Humsavar for RAI2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6527818 - 17,801,257(+) AGGCA(C/T)CGGGA nc-transcript-variant, reference, missense
rs17855524 - 17,800,987(+) TAGGG(C/G)TGCAT nc-transcript-variant, reference, missense
rs877766 -- 17,827,917(-) AAGGG(A/C)AAAAG intron-variant
rs960236 -- 17,815,138(-) CTTTA(A/G)GACAC intron-variant
rs1894582 -- 17,828,813(-) CCACA(A/G)AGCTC intron-variant

Variation tolerance for RAI2 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAI2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAI2 Gene

Disorders for RAI2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAI2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nance-horan syndrome
  • neonatal hemochromatosis
fried syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with RAI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAI2 Gene

Publications for RAI2 Gene

  1. Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22. (PMID: 10049581) Walpole S.M. … Trump D. (Genomics 1999) 2 3 4 67
  2. Exclusion of RAI2 as the causative gene for Nance-Horan syndrome. (PMID: 10394933) Walpole S.M. … Toutain A. (Hum. Genet. 1999) 2 3 23
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for RAI2 Gene

Sources for RAI2 Gene

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