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Aliases for RAI2 Gene

Aliases for RAI2 Gene

  • Retinoic Acid Induced 2 2 3

External Ids for RAI2 Gene

Previous GeneCards Identifiers for RAI2 Gene

  • GC0XM017362
  • GC0XM016484
  • GC0XM017020
  • GC0XM017179
  • GC0XM017578
  • GC0XM017728
  • GC0XM015576

Summaries for RAI2 Gene

Entrez Gene Summary for RAI2 Gene

  • Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for RAI2 Gene

RAI2 (Retinoic Acid Induced 2) is a Protein Coding gene. Diseases associated with RAI2 include nance-horan syndrome and fried syndrome.

Gene Wiki entry for RAI2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI2 Gene

Genomics for RAI2 Gene

Regulatory Elements for RAI2 Gene

Genomic Location for RAI2 Gene

Chromosome:
X
Start:
17,800,049 bp from pter
End:
17,861,346 bp from pter
Size:
61,298 bases
Orientation:
Minus strand

Genomic View for RAI2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAI2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI2 Gene

Proteins for RAI2 Gene

  • Protein details for RAI2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P3-RAI2_HUMAN
    Recommended name:
    Retinoic acid-induced protein 2
    Protein Accession:
    Q9Y5P3
    Secondary Accessions:
    • B1B1K2
    • B4DQM9
    • E7EMN4
    • Q8N6X7

    Protein attributes for RAI2 Gene

    Size:
    530 amino acids
    Molecular mass:
    57180 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RAI2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAI2 Gene

Proteomics data for RAI2 Gene at MOPED

Post-translational modifications for RAI2 Gene

  • Ubiquitination at Lys 266
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAI2 Gene

Domains & Families for RAI2 Gene

Protein Domains for RAI2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAI2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAI2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RAI2 Gene

Function for RAI2 Gene

Molecular function for RAI2 Gene

GENATLAS Biochemistry:
retinoic acid induced 2,expressed in heart,brain,placenta,lung,skeletal muscle,kidney,pancreas and retina,excluded as causing-disease gene in Nance-Horan syndrome

Gene Ontology (GO) - Molecular Function for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RAI2: view

Phenotypes for RAI2 Gene

GenomeRNAi human phenotypes for RAI2:
genes like me logo Genes that share phenotypes with RAI2: view

Animal Model Products

miRNA for RAI2 Gene

miRTarBase miRNAs that target RAI2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAI2 Gene

Localization for RAI2 Gene

Gene Ontology (GO) - Cellular Components for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with RAI2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for RAI2 Gene

Pathways & Interactions for RAI2 Gene

SuperPathways for RAI2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAI2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009790 embryo development NAS 10049581
genes like me logo Genes that share ontologies with RAI2: view

No data available for Pathways by source and SIGNOR curated interactions for RAI2 Gene

Drugs & Compounds for RAI2 Gene

No Compound Related Data Available

Transcripts for RAI2 Gene

Unigene Clusters for RAI2 Gene

Retinoic acid induced 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAI2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b
SP1: - - - - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for RAI2 Gene

GeneLoc Exon Structure for
RAI2
ECgene alternative splicing isoforms for
RAI2

Expression for RAI2 Gene

mRNA expression in normal human tissues for RAI2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAI2 Gene



SOURCE GeneReport for Unigene cluster for RAI2 Gene Hs.446680

genes like me logo Genes that share expression patterns with RAI2: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RAI2 Gene

Orthologs for RAI2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAI2 35
  • 86.11 (n)
  • 85.66 (a)
RAI2 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAI2 35
  • 87.81 (n)
  • 87.19 (a)
RAI2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rai2 35
  • 87.65 (n)
  • 89.98 (a)
Rai2 16
Rai2 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAI2 35
  • 98.07 (n)
  • 97.1 (a)
RAI2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rai2 35
  • 87.4 (n)
  • 90.93 (a)
oppossum
(Monodelphis domestica)
Mammalia RAI2 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAI2 35
  • 68.91 (n)
  • 65.7 (a)
RAI2 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAI2 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rai2 35
  • 60.08 (n)
  • 58.37 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885820 35
  • 50.32 (n)
  • 44.4 (a)
RAI2 36
  • 37 (a)
OneToOne
Species with no ortholog for RAI2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI2 Gene

ENSEMBL:
Gene Tree for RAI2 (if available)
TreeFam:
Gene Tree for RAI2 (if available)

Paralogs for RAI2 Gene

No data available for Paralogs for RAI2 Gene

Variants for RAI2 Gene

Sequence variations from dbSNP and Humsavar for RAI2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs877766 -- 17,827,917(-) AAGGG(A/C)AAAAG intron-variant
rs960236 -- 17,815,138(-) CTTTA(A/G)GACAC intron-variant
rs1894582 -- 17,828,813(-) CCACA(A/G)AGCTC intron-variant
rs2187846 -- 17,802,060(-) GAAGA(G/T)TCATA intron-variant
rs2213616 -- 17,800,527(-) CCTTA(A/G)GAAAC missense, reference, nc-transcript-variant

Variation tolerance for RAI2 Gene

Residual Variation Intolerance Score: 76.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAI2 Gene

HapMap Linkage Disequilibrium report
RAI2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAI2 Gene

Disorders for RAI2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAI2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
nance-horan syndrome
  • cataract dental syndrome
fried syndrome
- elite association
Search RAI2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RAI2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAI2
genes like me logo Genes that share disorders with RAI2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAI2 Gene

Publications for RAI2 Gene

  1. Exclusion of RAI2 as the causative gene for Nance-Horan syndrome. (PMID: 10394933) Walpole S.M. … Toutain A. (Hum. Genet. 1999) 2 23 67
  2. Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22. (PMID: 10049581) Walpole S.M. … Trump D. (Genomics 1999) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 67
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 67

Products for RAI2 Gene

Sources for RAI2 Gene

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