RAI2 Gene
protein-coding GIFtS : 53
GCID: GC0X M017818
retinoic acid induced 2
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Aliasesfor RAI2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section This gene clusters with an RNA geneSubcategory (RNA class): lncRNAQuality score for the ORGUL clustered with this gene is 3 Aliases Retinoic Acid Induced 2 1 2 Retinoic Acid-Induced Protein 22
External Ids: HGNC: 9835 1 Entrez Gene: 10742 2 Ensembl: ENSG00000131831 7 OMIM: 300217 5 UniProtKB: Q9Y5P3 3 ORGUL members: NONCODE:n409188 n409187
Export aliases for RAI2 gene to outside databases Previous GC identifers: GC0XM017362 GC0XM016484 GC0XM017020 GC0XM017179 GC0XM017578 GC0XM017728 GC0XM015576
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Summariesfor RAI2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for RAI2 : Retinoic acid plays a critical role in development, cellular growth, and differentiation. The specific function of this retinoic acid-induced gene has not yet been determined but it may play a role in development. The chromosomal location of this gene designates it to be a candidate for diseases such as Nance-Horan syndrome, sensorineural deafness, non-specific X-linked mental retardation, oral-facial-digital syndrome, and Fried syndrome. Alternate splicing results in multiple transcript variants. (provided by RefSeq, Feb 2010) Gene Wiki entry for RAI2
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Genomic Viewsfor RAI2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_167197.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the RAI2 gene promoter: HFH-3 C/EBPbeta Sox5 Lmo2 CUTL1 HNF-1A RORalpha1 FOXI1 E2F-1 HNF-1 Other transcription factors Search SABiosciences Chromatin IP Primers for RAI2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAI2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xp22 Ensembl cytogenetic band: Xp22.13 HGNC cytogenetic band: Xp22 RAI2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM017818: view genomic region
(about GC identifiers )
Start:
17,818,169 bp from pter
End:
17,879,457 bp from pter
Size:
61,289 bases
Orientation:
minus strand
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Proteinsfor RAI2 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RAI2_HUMAN, Q9Y5P3 (See
protein sequence )Recommended Name: Retinoic acid-induced protein 2 Size : 530 amino acids; 57180 Da
Secondary accessions : B1B1K2 Q8N6X7Explore the universe of human proteins at neXtProt for RAI2: NX_Q9Y5P3 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9Y5P3 RAI2 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts):
NP_001166203.1 NP_001166210.1 NP_001166214.1 NP_068557.3 ENSEMBL proteins: ENSP00000333456 ENSP00000353106 ENSP00000444210 ENSP00000401323 ENSP00000392578 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND --
RAI2 for ontologies About GeneDecksing RAI2 Antibody Products: Assay Products for RAI2:
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Protein
Domains / Familiesfor RAI2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
RAI2 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9Y5P3 ProtoNet protein and cluster: Q9Y5P3
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Functionfor RAI2 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for RAI2 : retinoic acid induced 2,expressed in heart,brain,placenta,lung,skeletal muscle,kidney,pancreas and retina,excluded as causing-disease gene in Nance-Horan syndrome Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): RAI2 (NM_021785 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAI2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAI2
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI2
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
RAI2 for ontologies About GeneDecksing
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Pathways & Interactionsfor RAI2 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAI2 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5 Interacting proteins for RAI2 (Q9Y5P3 1 , 2 , 3 ENSP00000333456 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
RAI2 for ontologies About GeneDecksing
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Drugs & Compoundsfor RAI2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for RAI2 Search CenterWatch for drugs/clinical trials and news about RAI2
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Transcriptsfor RAI2 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for RAI2 gene (4 alternative transcripts): NM_001172732.1 NM_001172739.1 NM_001172743.1 NM_021785.4 Unigene Cluster for RAI2:
Retinoic acid induced 2 Hs.446680 [show with all ESTs ] Unigene Representative Sequence: NR_033348 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000331511 ENST00000360011 (uc004cyf.3 uc004cyg.3 ) ENST00000545871 (uc022btl.1 uc004cyh.4 )ENST00000451717 (uc010nfa.3 ) ENST00000415486 (uc011miy.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 (see all 7 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 (see all 4 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): RAI2 (NM_021785 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAI2 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAI2
Additional cDNA sequence: AK056214.1 AK298873.1 AK314631.1 BC027937.1 NR_033348.1 NR_033349.1
8 DOTS entries : DT.121309261 DT.100035785
DT.100738675 DT.112527 DT.97825189 DT.99956029 DT.100719714 DT.121309272 24/56 AceView cDNA sequences (see all 56 ):
CR592976 AA045082 NM_021785 AI014566 BX118803 BE670727 BE503005 AI696330 BU728108 AI961859 AA121289 AI937418 BU076739 AA128005 W00683 BX382061 BC027937 C01114 AL709687 CD673707 BP375960 BX389771 AA343822 AA121303 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAI2 (see all 6 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b SP1 :             -     -   -   -   -       SP2 :       -   -   -                   SP3 :       -   -     -                 SP4 :         -     -                 SP5 :             -                
ECgene alternative splicing isoforms for RAI2
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Expression for RAI2 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section RAI2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTCCCAATCA
About this image RAI2 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See RAI2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for RAI2 SOURCE GeneReport for Unigene cluster: Hs.446680 SABiosciences Custom PCR Arrays for RAI2 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAI2Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat RAI2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAI2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAI2 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI2
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Orthologsfor RAI2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for RAI2 gene from 5/13 species (see all 13 ) About this table
ENSEMBL Gene Tree for RAI2 (if available)TreeFam Gene Tree for RAI2 (if available)
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Paralogsfor RAI2 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for RAI2 gene SOBP 2
RAI2 for paralogs About GeneDecksing
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Genomic Variantsfor RAI2 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for RAI2 (17818169 - 17879457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 8 variations for RAI2 2 CNVs : 96509 83372 6 Indels : 83374 83376 83377 96510 83373 83375 Locus Specific Mutation Databases (LSDB): RAI2
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAI2
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Disorders
/ Diseasesfor RAI2 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
RAI2 for disorders About GeneDecksing
OMIM gene information: 300217
OMIM disorders : --4 diseases for RAI2 : About MalaCards nance-horan syndrome oral-facial-digital syndrome cataract ataxia Export disorders for RAI2 gene to outside databases
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Publicationsfor RAI2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for RAI2 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with RAI2) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of the human homologue (RAI2) of a mouse retinoic acid-induced gene in Xp22. (PubMed id 10049581) 1 , 2 , 3 Walpole S.M.... Trump D. (1999) Exclusion of RAI2 as the causative gene for Nance-Horan syndrome. (PubMed id 10394933) 1 , 3, 9 Walpole S.M....Toutain A. (1999) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011) A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473) 1 Wagner S.A....Choudhary C. (2011) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569) 1 Lim J.... Zoghbi H.Y. (2006) The DNA sequence of the human X chromosome. (PubMed id 15772651) 2 Ross M.T.... Bentley D.R. (2005) Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514) 1 Rual J.F....Vidal M. (2005) Refinement of the X-linked cataract locus (CXN) and g ene analysis for CXN and Nance-Horan syndrome (NHS). (PubMed id 15370543) 1 Brooks S....Hardcastle A. (2004)
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External Searches for RAI2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing RAI2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing RAI2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing RAI2 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for RAI2 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for RAI2 gene: Search GeneIP for patents involving RAI2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor RAI2 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for RAI2 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for RAI2 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for RAI2 OriGene Protein Over-expression Lysate for RAI2 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for RAI2 OriGene 3'-UTR Clone for RAI2 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for RAI2 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for RAI2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for RAI2 OriGene Custom Protein Services for RAI2 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAI2 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing RAI2 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAI2 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat RAI2 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat RAI2 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat RAI2
Search Tocris compounds for RAI2
RAI2 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI2
ThermoFisher Antibodies for RAI2
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat RAI2
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Aliases for RAI2
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Expression for RAI2
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