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Aliases for RAI14 Gene

Aliases for RAI14 Gene

  • Retinoic Acid Induced 14 2 3
  • Ankyrin Repeat And Coiled-Coil Structure-Containing Protein 3 4
  • Novel Retinal Pigment Epithelial Cell Protein 3 4
  • Retinoic Acid-Induced Protein 14 3 4
  • KIAA1334 4 6
  • NORPEG 3 4
  • Novel Retinal Pigment Epithelial 2
  • Ankycorbin 3
  • RAI13 3

External Ids for RAI14 Gene

Summaries for RAI14 Gene

GeneCards Summary for RAI14 Gene

RAI14 (Retinoic Acid Induced 14) is a Protein Coding gene. An important paralog of this gene is UACA.

Gene Wiki entry for RAI14 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI14 Gene

Genomics for RAI14 Gene

Genomic Location for RAI14 Gene

Start:
34,656,237 bp from pter
End:
34,832,627 bp from pter
Size:
176,391 bases
Orientation:
Plus strand

Genomic View for RAI14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAI14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI14 Gene

Regulatory Elements for RAI14 Gene

Proteins for RAI14 Gene

  • Protein details for RAI14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0K7-RAI14_HUMAN
    Recommended name:
    Ankycorbin
    Protein Accession:
    Q9P0K7
    Secondary Accessions:
    • E9PED3
    • Q6V1W9
    • Q7Z5I4
    • Q7Z733
    • Q9P2L2
    • Q9Y3T5

    Protein attributes for RAI14 Gene

    Size:
    980 amino acids
    Molecular mass:
    110041 Da
    Quaternary structure:
    • Doesnt bind directly to F-actin.
    SequenceCaution:
    • Sequence=BAA92572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43236.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAI14 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAI14 Gene

Proteomics data for RAI14 Gene at MOPED

Post-translational modifications for RAI14 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys507 and Lys912

No data available for DME Specific Peptides for RAI14 Gene

Domains for RAI14 Gene

Gene Families for RAI14 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing

Protein Domains for RAI14 Gene

UniProtKB/Swiss-Prot:

RAI14_HUMAN
Similarity:
  • Contains 7 ANK repeats.:
    • Q9P0K7
genes like me logo Genes that share domains with RAI14: view

Function for RAI14 Gene

Molecular function for RAI14 Gene

UniProtKB/Swiss-Prot Induction: Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).

Gene Ontology (GO) - Molecular Function for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RAI14: view

Phenotypes for RAI14 Gene

GenomeRNAi human phenotypes for RAI14:
genes like me logo Genes that share phenotypes with RAI14: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAI14 Gene

Localization for RAI14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAI14 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Predominantly nuclear in nonconfluent cells. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAI14 Gene COMPARTMENTS Subcellular localization image for RAI14 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RAI14: view

Pathways for RAI14 Gene

SuperPathways for RAI14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with RAI14: view

No data available for Pathways by source for RAI14 Gene

Transcripts for RAI14 Gene

Unigene Clusters for RAI14 Gene

Retinoic acid induced 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAI14 Gene

No ASD Table

Relevant External Links for RAI14 Gene

GeneLoc Exon Structure for
RAI14
ECgene alternative splicing isoforms for
RAI14

Expression for RAI14 Gene

mRNA expression in normal human tissues for RAI14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAI14 Gene

SOURCE GeneReport for Unigene cluster for RAI14 Gene Hs.431400

mRNA Expression by UniProt/SwissProt for RAI14 Gene

Q9P0K7-RAI14_HUMAN
Tissue specificity: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
genes like me logo Genes that share expressions with RAI14: view

Orthologs for RAI14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAI14 36
  • 99.35 (n)
  • 99.49 (a)
RAI14 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAI14 36
  • 88.98 (n)
  • 92.45 (a)
RAI14 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAI14 36
  • 88.87 (n)
  • 91.83 (a)
RAI14 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rai14 36
  • 83.86 (n)
  • 85.47 (a)
Rai14 16
Rai14 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAI14 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAI14 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rai14 36
  • 83.91 (n)
  • 83.98 (a)
chicken
(Gallus gallus)
Aves RAI14 36
  • 71.76 (n)
  • 69.06 (a)
RAI14 37
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAI14 37
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4125 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rai14 36
  • 58.95 (n)
  • 52.53 (a)
zebrafish
(Danio rerio)
Actinopterygii rai14 36
  • 54.16 (n)
  • 45.27 (a)
rai14 37
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for RAI14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI14 Gene

ENSEMBL:
Gene Tree for RAI14 (if available)
TreeFam:
Gene Tree for RAI14 (if available)

Paralogs for RAI14 Gene

Paralogs for RAI14 Gene

genes like me logo Genes that share paralogs with RAI14: view

Variants for RAI14 Gene

Sequence variations from dbSNP and Humsavar for RAI14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1390 -- 34,683,313(-) AGTCC(A/G)TGGCT intron-variant, upstream-variant-2KB
rs12446 -- 34,831,643(+) TTTTC(A/G)TATCT utr-variant-3-prime
rs154121 -- 34,669,132(-) CACGC(C/T)TGTAA intron-variant
rs162909 -- 34,772,681(+) CCTGA(A/G)TCACC intron-variant
rs162910 -- 34,759,069(+) accag(C/T)ctggc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAI14 Gene

Variant ID Type Subtype PubMed ID
nsv519240 CNV Gain 19592680
nsv830260 CNV Gain 17160897
nsv4786 CNV Insertion 18451855
esv24799 CNV Loss 19812545
esv26730 CNV Loss 19812545
esv271666 CNV Insertion 20981092
esv274357 CNV Insertion 20981092
nsv4787 CNV Insertion 18451855
nsv522144 CNV Loss 19592680

Relevant External Links for RAI14 Gene

HapMap Linkage Disequilibrium report
RAI14

Disorders for RAI14 Gene

Relevant External Links for RAI14

Genetic Association Database (GAD)
RAI14
Human Genome Epidemiology (HuGE) Navigator
RAI14
genes like me logo Genes that share disorders with RAI14: view

No data available for UniProtKB/Swiss-Prot for RAI14 Gene

Publications for RAI14 Gene

  1. Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. (PMID: 16729964) Kutty R.K. … Wiggert B. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  2. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. (PMID: 11042181) Kutty R.K. … Wiggert B. (J. Biol. Chem. 2001) 2 3 4
  3. Ankycorbin: a novel actin cytoskeleton-associated protein. (PMID: 11168586) Peng Y.-F. … Takai Y. (Genes Cells 2000) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAI14 Gene

Sources for RAI14 Gene

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