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RAI14 Gene

protein-coding   GIFtS: 57
GCID: GC05P034656

Retinoic Acid Induced 14

  Search for RAI14
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Retinoic Acid Induced 141 2     KIAA13343 5
Ankyrin Repeat And Coiled-Coil Structure-Containing Protein2 3     Novel Retinal Pigment Epithelial1
Novel Retinal Pigment Epithelial Cell Protein2 3     RAI132
Retinoic Acid-Induced Protein 142 3     ankycorbin2
NORPEG2 3     

External Ids:    HGNC: 148731   Entrez Gene: 260642   Ensembl: ENSG000000395607   OMIM: 6065865   UniProtKB: Q9P0K73   

Export aliases for RAI14 gene to outside databases

Previous GC identifers: GC05P034689 GC05P035682 GC05P034702 GC05P034692


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAI14 Gene:
RAI14 (retinoic acid induced 14) is a protein-coding gene. An important paralog of this gene is UACA.

Gene Wiki entry for RAI14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAI14 gene promoter:
         E2F-3a   E2F-1   E2F   E2F-2   Roaz   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): RAI14 promoter sequence
   Search Chromatin IP Primers for RAI14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAI14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.3-p13.2   Ensembl cytogenetic band:  5p13.2   HGNC cytogenetic band: 5p13.3-p13.2

RAI14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAI14 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P034656:  view genomic region     (about GC identifiers)

Start:
34,656,342 bp from pter      End:
34,832,732 bp from pter
Size:
176,391 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7 (See protein sequence)
Recommended Name: Ankycorbin  
Size: 980 amino acids; 110041 Da
Subunit: Doesn't bind directly to F-actin (By similarity)
Sequence caution: Sequence=BAA92572.1; Type=Erroneous initiation; Sequence=CAB43236.2; Type=Erroneous initiation;
Secondary accessions: E9PED3 Q6V1W9 Q7Z5I4 Q7Z733 Q9P2L2 Q9Y3T5
Alternative splicing: 4 isoforms:  Q9P0K7-1   Q9P0K7-2   Q9P0K7-3   Q9P0K7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAI14: NX_Q9P0K7

Explore proteomics data for RAI14 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys507, Lys912
  • Modification sites at PhosphoSitePlus

  • See RAI14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001138992.1  NP_001138993.1  NP_001138994.1  NP_001138995.1  NP_001138997.1  NP_056392.2  

    ENSEMBL proteins: 
     ENSP00000265109   ENSP00000424879   ENSP00000424507   ENSP00000422112   ENSP00000422377  
     ENSP00000388725   ENSP00000421424   ENSP00000423965   ENSP00000422942   ENSP00000422515  
     ENSP00000422114   ENSP00000424502   ENSP00000427123   ENSP00000426770   ENSP00000425337  
     ENSP00000425929   ENSP00000425115   ENSP00000423854   ENSP00000380591  

    RAI14 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAI14

     
    Search eBioscience for Proteins for RAI14 

    RAI14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAI14
    Cloud-Clone Corp. CLIAs for RAI14
    Search eBioscience for ELISAs for RAI14 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing

    2 InterPro protein domains:
     IPR002110 Ankyrin_rpt
     IPR020683 Ankyrin_rpt-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9P0K7

    ProtoNet protein and cluster: Q9P0K7

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7
    Similarity: Contains 7 ANK repeats


    Find genes that share domains with RAI14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAI14_HUMAN, Q9P0K7
    Induction: Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with RAI14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAI14:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAI14
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAI14

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAI14
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAI14

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAI14:
    hsa-mir-26b-5p (MIRT029203), hsa-mir-155-5p (MIRT001508), hsa-mir-21-5p (MIRT030827), hsa-mir-423-3p (MIRT042582), hsa-mir-122-5p (MIRT023221)

    Block miRNA regulation of human, mouse, rat RAI14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAI14 (see all 63):
    hsa-miR-21* hsa-miR-548j hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p hsa-miR-570 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidRAI14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAI14
    Predesigned siRNA for gene silencing in human, mouse, rat RAI14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAI14

    Clone
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    OriGene clones in human, mouse for RAI14 (see all 34)
    OriGene ORF clones in mouse, rat for RAI14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): RAI14 (NM_001145520)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAI14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAI14

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RAI14
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAI14 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI14


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAI14_HUMAN, Q9P0K7: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Nucleus.
    Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and
    stress fibers (By similarity). Predominantly nuclear in nonconfluent cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    mitochondrion2
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IEA--
    GO:0005856cytoskeleton ----

    Find genes that share ontologies with RAI14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAI14
    Interactions:

        Search GeneGlobe Interaction Network for RAI14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for RAI14 (Q9P0K72, 3 ENSP000002651094) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K3Q997592, 3MINT-48475 I2D: score=2 
    RIPK3Q9Y5722, 3MINT-49134 I2D: score=2 
    YWHAQP273482, 3, ENSP000002380814MINT-51002 I2D: score=4 STRING: ENSP00000238081
    YWHABP319462, 3, ENSP000003001614MINT-50995 I2D: score=4 STRING: ENSP00000300161
    YWHAZP631042, 3, ENSP000003095034MINT-3319917 I2D: score=3 STRING: ENSP00000309503
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016192vesicle-mediated transport ----

    Find genes that share ontologies with RAI14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAI14



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAI14 gene (6 alternative transcripts): 
    NM_001145520.1  NM_001145521.1  NM_001145522.1  NM_001145523.1  NM_001145525.1  NM_015577.2  

    Unigene Cluster for RAI14:

    Retinoic acid induced 14
    Hs.431400  [show with all ESTs]
    Unigene Representative Sequence: NM_001145525
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000265109(uc003jir.3 uc010iur.3 uc003jis.3 uc003jit.3 uc011cok.2)
    ENST00000514527 ENST00000510319 ENST00000514931 ENST00000513974 ENST00000512629
    ENST00000428746(uc011coj.2) ENST00000514873 ENST00000508777 ENST00000503673(uc010ius.1)
    ENST00000511652 ENST00000504052 ENST00000512305 ENST00000514036 ENST00000515799
    ENST00000510386 ENST00000508315 ENST00000515448
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAI14 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAI14 (see all 63):
    hsa-miR-21* hsa-miR-548j hsa-miR-3607-3p hsa-miR-128 hsa-miR-30d hsa-miR-502-3p hsa-miR-570 hsa-miR-3167
    SwitchGear 3'UTR luciferase reporter plasmidRAI14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAI14
    Predesigned siRNA for gene silencing in human, mouse, rat RAI14
    Clone
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    OriGene clones in human, mouse for RAI14 (see all 34)
    OriGene ORF clones in mouse, rat for RAI14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): RAI14 (NM_001145520)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAI14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAI14
    Primer
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    OriGene qPCR primer pairs and template standards for RAI14
    OriGene qSTAR qPCR primer pairs in human, mouse for RAI14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAI14
      QuantiTect SYBR Green Assays in human, mouse, rat RAI14
      QuantiFast Probe-based Assays in human, mouse, rat RAI14

    Additional mRNA sequence: 

    AB037755.1 AF155135.1 AK023135.1 AK297964.1 AK308306.1 AK308455.1 AK314379.1 AL050011.1 
    AY317139.1 AY354204.2 BC028681.1 BC052988.1 

    18 DOTS entries:

    DT.447458  DT.97769861  DT.100650627  DT.120871327  DT.120871372  DT.100673028  DT.92438870  DT.75100161 
    DT.120871312  DT.95076981  DT.95172107  DT.100792307  DT.102833477  DT.120871296  DT.120871335  DT.120871373 
    DT.40125013  DT.92036024 

    Selected AceView cDNA sequences (see all 285):

    BE501565 AW243942 BM661952 AF155135 AU131014 AA884858 AA295497 CD656694 
    AI950246 AL042606 AW631209 AI214190 BQ000114 CB132677 AI086358 BQ017180 
    AI872068 AA864840 BG110310 CA311276 T35474 BE315062 AI273714 BQ005515 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAI14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAAAACC
    RAI14 Expression
    About this image


    RAI14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Gonad (Reproductive System)
             Testis Somatic Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Testis (Reproductive System)
             Testis Somatic Cells Primitive Gonad
    RAI14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAI14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.431400

    UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7
    Tissue specificity: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain,
    lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for RAI14 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rai141 , 5 retinoic acid induced 141, 5 83.86(n)1
    85.47(a)1
      15 (5.35 cM)5
    756461  NM_001166408.11  NP_001159880.11 
     105689795 
    chicken
    (Gallus gallus)
    Aves RAI141 retinoic acid induced 14 71.76(n)
    69.06(a)
      427431  XM_425003.4  XP_425003.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAI146
    retinoic acid induced 14
    61(a)
    1 ↔ 1
    GL343241.1(2067223-2090224)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41252 Xenopus laevis transcribed sequence with moderate similarity more 81.31(n)    BX843877.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rai141 retinoic acid induced 14 54.16(n)
    45.27(a)
      794796  NM_001111217.2  NP_001104687.2 


    ENSEMBL Gene Tree for RAI14 (if available)
    TreeFam Gene Tree for RAI14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAI14 gene
    UACA2  ANKRD242  ANKRD352  
    Selected SIMAP similar genes for RAI14 using alignment to 12 protein entries:     RAI14_HUMAN (see all proteins) (see all similar genes):
    ANKRD24    ANKRD35    UACA    PPP1R12A    SNCAIP    HACE1
    PPP1R12C    PPP1R27    ANKRD6    ANKRD65    ANKRD46    ANK2
    TANC2    ANKRD54    ANK3    TNKS    AGAP1    ACAP3

    Find genes that share paralogs with RAI14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAI14 (see all 3575)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs4588571,2
    C,F,A--34654441(+) CCCCAC/ATAATC 2 -- us2k1 tfbs311Minor allele frequency- A:0.43WA NA CSA EA 374
    rs1507439821,2
    C--34654447(+) TAATCC/TCCCTG 2 -- us2k10--------
    rs1911588431,2
    --34654470(+) CTTAGA/CTGCCA 2 -- us2k10--------
    rs4646091,2
    C,F,A,H--34654477(+) GCCATG/ACTCAG 2 -- us2k124Minor allele frequency- A:0.45MN NS EA WA NA CSA 2526
    rs1821314631,2
    --34654479(+) CATGCG/TCAGTC 2 -- us2k10--------
    rs1401497781,2
    C--34654615(+) AGGGTA/GGGAGT 3 -- us2k10--------
    rs1865728851,2
    --34654740(+) TGAATC/TAAAGT 3 -- us2k10--------
    rs1421527111,2
    --34654782(+) AATGTC/TGTCTA 3 -- us2k10--------
    rs1922957131,2
    --34654865(+) TCTACC/TTGTAC 3 -- us2k10--------
    rs752916651,2
    C--34654950(+) ACAGGC/TAGTAA 3 -- us2k14Minor allele frequency- T:0.08CSA WA NA EA 360

    HapMap Linkage Disequilibrium report for RAI14 (34656342 - 34832732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RAI14:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4787CNV Insertion18451855
    esv274357CNV Insertion20981092
    nsv4786CNV Insertion18451855
    esv271666CNV Insertion20981092
    esv26730CNV Loss19812545
    nsv522144CNV Loss19592680
    esv24799CNV Loss19812545
    nsv519240CNV Gain19592680
    nsv830260CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606586    OMIM disorders: --


    Find genes that share disorders with RAI14           About GenesLikeMe

    Genetic Association Database (GAD): RAI14
    Human Genome Epidemiology (HuGE) Navigator: RAI14 (1 document)

    Export disorders for RAI14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAI14 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with RAI14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. (PubMed id 11042181)1, 2, 3 Kutty R.K.... Wiggert B. (J. Biol. Chem. 2001)
    2. Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. (PubMed id 16729964)1, 2, 9 Kutty R.K.... Wiggert B. (Biochem. Biophys. Res. Commun. 2006)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study. (PubMed id 19454037)1, 4 Arnett D.K....Broeckel U. (BMC Med. Genet. 2009)
    5. Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes. (PubMed id 16110356)1, 2 Yuan W.... Sha J.-H. (Asian J. Androl. 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Ankycorbin: a novel actin cytoskeleton-associated protein. (PubMed id 11168586)1, 2 Peng Y.-F.... Takai Y. (Genes Cells 2000)
    9. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    10. The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. (PubMed id 23398456)1 Bett J.S....Hay R.T. (Biochem. J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26064 HGNC: 14873 AceView: RAI14 Ensembl:ENSG00000039560 euGenes: HUgn26064
    ECgene: RAI14 H-InvDB: RAI14

    (According to HUGE)
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    HUGE: KIAA1334

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAI14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAI14 gene:
    Search GeneIP for patents involving RAI14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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