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Aliases for RAI14 Gene

Aliases for RAI14 Gene

  • Retinoic Acid Induced 14 2 3
  • Ankyrin Repeat And Coiled-Coil Structure-Containing Protein 3 4
  • Novel Retinal Pigment Epithelial Cell Protein 3 4
  • Retinoic Acid-Induced Protein 14 3 4
  • KIAA1334 4 6
  • NORPEG 3 4
  • Novel Retinal Pigment Epithelial 2
  • Ankycorbin 3
  • RAI13 3

External Ids for RAI14 Gene

Previous GeneCards Identifiers for RAI14 Gene

  • GC05P034689
  • GC05P035682
  • GC05P034702
  • GC05P034692

Summaries for RAI14 Gene

GeneCards Summary for RAI14 Gene

RAI14 (Retinoic Acid Induced 14) is a Protein Coding gene. An important paralog of this gene is UACA.

Gene Wiki entry for RAI14 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI14 Gene

Genomics for RAI14 Gene

Regulatory Elements for RAI14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAI14 Gene

34,656,237 bp from pter
34,832,627 bp from pter
176,391 bases
Plus strand

Genomic View for RAI14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAI14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI14 Gene

Proteins for RAI14 Gene

  • Protein details for RAI14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E9PED3
    • Q6V1W9
    • Q7Z5I4
    • Q7Z733
    • Q9P2L2
    • Q9Y3T5

    Protein attributes for RAI14 Gene

    980 amino acids
    Molecular mass:
    110041 Da
    Quaternary structure:
    • Doesnt bind directly to F-actin.
    • Sequence=BAA92572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43236.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAI14 Gene


neXtProt entry for RAI14 Gene

Proteomics data for RAI14 Gene at MOPED

Post-translational modifications for RAI14 Gene

  • Ubiquitination at Lys507 and Lys912
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAI14 Gene

Domains for RAI14 Gene

Gene Families for RAI14 Gene

Protein Domains for RAI14 Gene

Suggested Antigen Peptide Sequences for RAI14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 7 ANK repeats.
  • Contains 7 ANK repeats.
genes like me logo Genes that share domains with RAI14: view

Function for RAI14 Gene

Molecular function for RAI14 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).

Gene Ontology (GO) - Molecular Function for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RAI14: view

Phenotypes for RAI14 Gene

GenomeRNAi human phenotypes for RAI14:
genes like me logo Genes that share phenotypes with RAI14: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAI14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAI14 Gene

Localization for RAI14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAI14 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Predominantly nuclear in nonconfluent cells. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAI14 Gene COMPARTMENTS Subcellular localization image for RAI14 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
mitochondrion 2
cytosol 1

Gene Ontology (GO) - Cellular Components for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IEA --
GO:0005938 cell cortex IEA --
genes like me logo Genes that share ontologies with RAI14: view

Pathways for RAI14 Gene

SuperPathways for RAI14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with RAI14: view

No data available for Pathways by source for RAI14 Gene

Transcripts for RAI14 Gene

Unigene Clusters for RAI14 Gene

Retinoic acid induced 14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAI14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAI14 Gene

No ASD Table

Relevant External Links for RAI14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAI14 Gene

mRNA expression in normal human tissues for RAI14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for RAI14 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.3) and Bone marrow stromal cell (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAI14 Gene

SOURCE GeneReport for Unigene cluster for RAI14 Gene Hs.431400

mRNA Expression by UniProt/SwissProt for RAI14 Gene

Tissue specificity: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
genes like me logo Genes that share expressions with RAI14: view

Expression partners for RAI14 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for RAI14 Gene

Orthologs for RAI14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RAI14 35
  • 88.98 (n)
  • 92.45 (a)
RAI14 36
  • 92 (a)
(Canis familiaris)
Mammalia RAI14 35
  • 88.87 (n)
  • 91.83 (a)
RAI14 36
  • 91 (a)
(Mus musculus)
Mammalia Rai14 35
  • 83.86 (n)
  • 85.47 (a)
Rai14 16
Rai14 36
  • 84 (a)
(Pan troglodytes)
Mammalia RAI14 35
  • 99.35 (n)
  • 99.49 (a)
RAI14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Rai14 35
  • 83.91 (n)
  • 83.98 (a)
(Monodelphis domestica)
Mammalia RAI14 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RAI14 36
  • 72 (a)
(Gallus gallus)
Aves RAI14 35
  • 71.76 (n)
  • 69.06 (a)
RAI14 36
  • 67 (a)
(Anolis carolinensis)
Reptilia RAI14 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rai14 35
  • 58.95 (n)
  • 52.53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4125 35
(Danio rerio)
Actinopterygii rai14 35
  • 54.16 (n)
  • 45.27 (a)
rai14 36
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for RAI14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI14 Gene

Gene Tree for RAI14 (if available)
Gene Tree for RAI14 (if available)

Paralogs for RAI14 Gene

Paralogs for RAI14 Gene

genes like me logo Genes that share paralogs with RAI14: view

Variants for RAI14 Gene

Sequence variations from dbSNP and Humsavar for RAI14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs1390 -- 34,683,313(-) AGTCC(A/G)TGGCT intron-variant, upstream-variant-2KB
rs162912 -- 34,760,978(+) aaatg(C/T)aatca intron-variant
rs162914 -- 34,742,426(+) GAATA(C/T)CTAAA intron-variant
rs163121 -- 34,794,023(+) AGGTG(A/G)ACTTA intron-variant
rs163122 -- 34,806,210(+) ggtca(C/G)aaagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAI14 Gene

Variant ID Type Subtype PubMed ID
nsv519240 CNV Gain 19592680
nsv830260 CNV Gain 17160897
nsv4786 CNV Insertion 18451855
esv24799 CNV Loss 19812545
esv26730 CNV Loss 19812545
esv271666 CNV Insertion 20981092
esv274357 CNV Insertion 20981092
nsv4787 CNV Insertion 18451855
nsv522144 CNV Loss 19592680

Relevant External Links for RAI14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAI14 Gene

Disorders for RAI14 Gene

Relevant External Links for RAI14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for RAI14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for RAI14 Gene

Publications for RAI14 Gene

  1. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. (PMID: 11042181) Kutty R.K. … Wiggert B. (J. Biol. Chem. 2001) 2 3 4
  2. Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. (PMID: 16729964) Kutty R.K. … Wiggert B. (Biochem. Biophys. Res. Commun. 2006) 3 4 23
  3. Ankycorbin: a novel actin cytoskeleton-associated protein. (PMID: 11168586) Peng Y.-F. … Takai Y. (Genes Cells 2000) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RAI14 Gene

Sources for RAI14 Gene

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