RAI14 Gene
protein-coding GIFtS: 54
GCID: GC05P034692
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retinoic acid induced 14
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Aliases
for RAI14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoic Acid Induced 141 2 | | Novel Retinal Pigment Epithelial Cell Protein2 3 | | NORPEG1 2 3 | | Retinoic Acid-Induced Protein 142 3 | | KIAA13341 3 5 | | DKFZp564G0131 | | RAI131 2 | | Ankycorbin1 | | Ankyrin Repeat And Coiled-Coil Structure-Containing Protein2 3 | | |
Export aliases for RAI14 gene to outside databasesPrevious GC identifers: GC05P034689 GC05P035682 GC05P034702 |
Summaries
for RAI14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for RAI14
|
Genomic Views
for RAI14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_006576.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAI14 gene promoter:
E2F-3a E2F-1 E2F E2F-2 Roaz c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAI14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAI14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5p13.3-p13.2 Ensembl cytogenetic band: 5p13.2 HGNC cytogenetic band: 5p13.3-p13.2RAI14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P034692: view genomic region
(about GC identifiers)
Start:
|
34,656,342 bp from pter |
End:
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34,832,732 bp from pter |
Size:
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176,391 bases |
Orientation:
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plus strand |
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Proteins
for RAI14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7 (See
protein sequence)Recommended Name: Ankycorbin Size: 980 amino acids; 110041 Da
Subunit: Doesn't bind directly to F-actin (By similarity)
Subcellular location: Cytoplasm, cell cortex (By similarity). Cytoplasm, cytoskeleton (By similarity). Nucleus.Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites andstress fibers (By similarity). Predominantly nuclear in nonconfluent cells
Sequence caution: Sequence=BAA92572.1; Type=Erroneous initiation; Sequence=CAB43236.2; Type=Erroneous initiation;
Secondary accessions: E9PED3 Q6V1W9 Q7Z5I4 Q7Z733 Q9P2L2 Q9Y3T5Alternative splicing: 4 isoforms: Q9P0K7-1 Q9P0K7-2 Q9P0K7-3 Q9P0K7-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAI14: NX_Q9P0K7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9P0K7
RAI14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (6 alternative transcripts):
NP_001138992.1 NP_001138993.1 NP_001138994.1 NP_001138995.1 NP_001138997.1 NP_056392.2
ENSEMBL proteins: ENSP00000265109 ENSP00000424879 ENSP00000424507 ENSP00000422112 ENSP00000422377 ENSP00000388725 ENSP00000421424 ENSP00000423965 ENSP00000422942 ENSP00000422515 ENSP00000422114 ENSP00000424502 ENSP00000427123 ENSP00000426770 ENSP00000425337 ENSP00000425929 ENSP00000425115 ENSP00000423854 ENSP00000380591
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
RAI14 for ontologies About GeneDecksing
RAI14 Antibody Products:
Assay Products for RAI14: |
Protein
Domains /
Families
for RAI14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAI14 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9P0K7ProtoNet protein and cluster: Q9P0K7 1 Blocks protein family: IPB002110 Ankyrin repeat signature
UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7Similarity: Contains 7 ANK repeats |
Function
for RAI14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7Induction: Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for RAI14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAI14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI14 |
1 GenomeRNAi human phenotype for RAI14:
|
Pathways & Interactions
for RAI14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAI14
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/23 Interacting proteins for RAI14 (Q9P0K72, 3 ENSP000002651094) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
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Drugs & Compounds
for RAI14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAI14
Search CenterWatch for drugs/clinical trials and news about RAI14
|
Transcripts
for RAI14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAI14 gene (6 alternative transcripts): NM_001145520.1 NM_001145521.1 NM_001145522.1 NM_001145523.1 NM_001145525.1 NM_015577.2 Unigene Cluster for RAI14: Retinoic acid induced 14 Hs.431400 [show with all ESTs]Unigene Representative Sequence: NM_00114552518/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29): ENST00000265109(uc003jir.3 uc010iur.3 uc003jis.3 uc003jit.3 uc011cok.2)
ENST00000514527 ENST00000510319 ENST00000514931 ENST00000513974 ENST00000512629
ENST00000428746(uc011coj.2) ENST00000514873 ENST00000508777 ENST00000503673(uc010ius.1)
ENST00000511652 ENST00000504052 ENST00000512305 ENST00000514036 ENST00000515799
ENST00000510386 ENST00000508315 ENST00000515448
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 6): RAI14 (NM_001145520) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAI14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAI14 |
Additional cDNA sequence: AB037755.1 AF155135.1 AK023135.1 AK297964.1 AK308306.1 AK308455.1 AK314379.1 AL050011.1 AY317139.1 AY354204.2 BC028681.1 BC052988.1 18 DOTS entries: DT.447458 DT.97769861 DT.100650627 DT.120871327 DT.120871372 DT.100673028 DT.92438870 DT.75100161 DT.120871312 DT.95076981 DT.95172107 DT.100792307 DT.102833477 DT.120871296 DT.120871335 DT.120871373 DT.40125013 DT.92036024 24/285 AceView cDNA sequences (see all 285): AI950246 AA709398 AI086358 AF155135 AA864840 AK023135 AL042606 AW631209 AL041850 AA295497 CB125143 AW236025 AA599935 BG251185 AL050011 AI336525 BQ007779 BM832685 W46846 BM997297 CD656694 CA422472 NM_015577 AI273714
GeneLoc Exon Structure
|
Expression
for RAI14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAI14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAAAAACC
About this image
See RAI14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAI14
SOURCE GeneReport for Unigene cluster: Hs.431400
UniProtKB/Swiss-Prot: RAI14_HUMAN, Q9P0K7Tissue specificity: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain,lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa
SABiosciences Custom PCR Arrays for RAI14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAI14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAI14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAI14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAI14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI14 |
Orthologs
for RAI14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RAI14 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for RAI14 (if available)
TreeFam Gene Tree for RAI14 (if available) |
Paralogs
for RAI14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAI14 gene
- UACA2 ANKRD242 ANKRD352
18/43 SIMAP similar genes for RAI14 using alignment to 12 protein entries: RAI14_HUMAN (see all proteins)
(see all similar genes):ANKRD35 UACA PPP1R12A SNCAIP HACE1 PPP1R12C
PPP1R27 ANKRD6 ANKRD65 ANKRD46 ANK2 TANC2
ANKRD54 ANK3 TNKS AGAP1 ACAP3 ANKHD1
RAI14 for paralogs About GeneDecksing
|
Genomic Variants
for RAI14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAI14 (34656342 - 34832732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for RAI14
2 CNVs: 69052 64180
2 Indels: 64181 40746 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAI14 |
|
Disorders
/ Diseases
for RAI14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAI14 for disorders About GeneDecksing
OMIM gene information: 606586
OMIM disorders: --
4  diseases for RAI14: About MalaCardsretinitis chronic lymphocytic leukemia lymphocytic leukemia leukemia
Human Genome Epidemiology (HuGE) Navigator: RAI14 (1 document)
Export disorders for RAI14 gene to outside databases
|
Publications
for RAI14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAI14 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with RAI14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. (PubMed id 11042181)1, 2, 3 Kutty R.K.... Wiggert B. (2001)
- Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. (PubMed id 16729964)1, 2, 9 Kutty R.K....Wiggert B. (2006)
- Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes. (PubMed id 16110356)1, 2 Yuan W.... Sha J.-H. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Ankycorbin: a novel actin cytoskeleton-associated protein. (PubMed id 11168586)1, 2 Peng Y.-F.... Takai Y. (2000)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
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External Searches for RAI14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAI14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAI14 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing RAI14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RAI14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for RAI14 gene:
Search GeneIP for patents involving RAI14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAI14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAI14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAI14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAI14 | | | OriGene Protein Over-expression Lysate for RAI14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAI14 | | OriGene 3'-UTR Clone for RAI14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAI14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAI14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAI14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAI14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAI14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAI14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAI14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAI14 |
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 | | | RAI14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAI14 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAI14 |
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