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Aliases for RAI14 Gene

Aliases for RAI14 Gene

  • Retinoic Acid Induced 14 2 3 5
  • Ankyrin Repeat And Coiled-Coil Structure-Containing Protein 3 4
  • Novel Retinal Pigment Epithelial Cell Protein 3 4
  • Retinoic Acid-Induced Protein 14 3 4
  • NORPEG 3 4
  • Novel Retinal Pigment Epithelial 2
  • Ankycorbin 3
  • KIAA1334 4
  • RAI13 3

External Ids for RAI14 Gene

Previous GeneCards Identifiers for RAI14 Gene

  • GC05P034689
  • GC05P035682
  • GC05P034702
  • GC05P034692

Summaries for RAI14 Gene

GeneCards Summary for RAI14 Gene

RAI14 (Retinoic Acid Induced 14) is a Protein Coding gene. An important paralog of this gene is UACA.

Gene Wiki entry for RAI14 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAI14 Gene

Genomics for RAI14 Gene

Regulatory Elements for RAI14 Gene

Enhancers for RAI14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G034654 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.6 +2.3 2313 7.8 PKNOX1 CREB3L1 SIN3A ZNF2 YY1 FOS KLF13 SP3 SP5 MXD4 RAI14 SPEF2 LOC105374753 GC05P034707
GH05G034682 1.6 Ensembl ENCODE dbSUPER 17.4 +29.6 29626 7.2 FOXA2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 FOS ZNF263 SP3 RAI14 LOC105374753 TTC23L GC05P034707
GH05G034585 2 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -69.2 -69183 3.9 HDGF FOXA2 PKNOX1 ARNT SIN3A ZNF766 FOS ZNF263 JUNB SMARCB1 RAI14 LOC105374753 TTC23L LOC105374721
GH05G034714 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +61.1 61091 5.2 JUN TEAD4 ZNF140 SIN3A MAX FEZF1 RBBP5 CHD7 GATA2 POLR2A TTC23L RAI14 LOC105374753 GC05P034707 PIR47065
GH05G034625 1.1 ENCODE dbSUPER 17.9 -28.8 -28843 3.4 ATF1 INSM2 ZNF2 RFX5 ZEB1 ZNF335 GATA2 ZNF366 FOS ZNF263 RAI14 LOC105374753 LOC105374721
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAI14 on UCSC Golden Path with GeneCards custom track

Promoters for RAI14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179354 563 2801 PKNOX1 CREB3L1 SIN3A ZNF2 YY1 FOS KLF13 SP3 SP5 MXD4

Genomic Location for RAI14 Gene

34,656,237 bp from pter
34,832,627 bp from pter
176,391 bases
Plus strand

Genomic View for RAI14 Gene

Genes around RAI14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAI14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAI14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAI14 Gene

Proteins for RAI14 Gene

  • Protein details for RAI14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E9PED3
    • Q6V1W9
    • Q7Z5I4
    • Q7Z733
    • Q9P2L2
    • Q9Y3T5

    Protein attributes for RAI14 Gene

    980 amino acids
    Molecular mass:
    110041 Da
    Quaternary structure:
    • Doesnt bind directly to F-actin.
    • Sequence=BAA92572.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB43236.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAI14 Gene


neXtProt entry for RAI14 Gene

Post-translational modifications for RAI14 Gene

  • Ubiquitination at isoforms=2, 3, 4507 and isoforms=2, 3, 4912
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAI14 Gene

Domains & Families for RAI14 Gene

Gene Families for RAI14 Gene

Protein Domains for RAI14 Gene

Suggested Antigen Peptide Sequences for RAI14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAI14: view

No data available for UniProtKB/Swiss-Prot for RAI14 Gene

Function for RAI14 Gene

Molecular function for RAI14 Gene

UniProtKB/Swiss-Prot Induction:
Up-regulated by all-trans-retinoic acid (ATRA) in retinal pigment epithelial cells (ARPE-19).
genes like me logo Genes that share phenotypes with RAI14: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAI14 Gene

Localization for RAI14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAI14 Gene

Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Nucleus. Note=Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites and stress fibers (By similarity). Predominantly nuclear in nonconfluent cells. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAI14 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RAI14: view

Pathways & Interactions for RAI14 Gene

SuperPathways for RAI14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAI14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097190 apoptotic signaling pathway IEA --
GO:1901222 regulation of NIK/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with RAI14: view

No data available for Pathways by source and SIGNOR curated interactions for RAI14 Gene

Drugs & Compounds for RAI14 Gene

No Compound Related Data Available

Transcripts for RAI14 Gene

Unigene Clusters for RAI14 Gene

Retinoic acid induced 14:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAI14 Gene

No ASD Table

Relevant External Links for RAI14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAI14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAI14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAI14 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (28.3) and Bone marrow stromal cell (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAI14 Gene

Protein tissue co-expression partners for RAI14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAI14 Gene:


SOURCE GeneReport for Unigene cluster for RAI14 Gene:


mRNA Expression by UniProt/SwissProt for RAI14 Gene:

Tissue specificity: Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.

Evidence on tissue expression from TISSUES for RAI14 Gene

  • Nervous system(4.6)
  • Eye(4.3)
  • Liver(4.3)
  • Skin(4.3)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RAI14: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAI14 Gene

Orthologs for RAI14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAI14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAI14 34 35
  • 99.35 (n)
(Bos Taurus)
Mammalia RAI14 34 35
  • 88.98 (n)
(Canis familiaris)
Mammalia RAI14 34 35
  • 88.87 (n)
(Rattus norvegicus)
Mammalia Rai14 34
  • 83.91 (n)
(Mus musculus)
Mammalia Rai14 34 16 35
  • 83.86 (n)
(Monodelphis domestica)
Mammalia RAI14 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia RAI14 35
  • 72 (a)
(Gallus gallus)
Aves RAI14 34 35
  • 71.76 (n)
(Anolis carolinensis)
Reptilia RAI14 35
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rai14 34
  • 58.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.4125 34
(Danio rerio)
Actinopterygii rai14 34 35
  • 54.16 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 26 (a)
Species where no ortholog for RAI14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAI14 Gene

Gene Tree for RAI14 (if available)
Gene Tree for RAI14 (if available)

Paralogs for RAI14 Gene

Variants for RAI14 Gene

Sequence variations from dbSNP and Humsavar for RAI14 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000005700 -- 34,688,214(+) GCCTA(C/T)ATATC intron-variant, reference, missense
rs1000013357 -- 34,732,127(+) CAGCA(C/T)TGGGC intron-variant, upstream-variant-2KB
rs1000074508 -- 34,739,464(+) TAGAA(C/T)AGACA intron-variant
rs1000079767 -- 34,689,803(+) GAAGG(C/T)GGAGG intron-variant
rs1000105464 -- 34,685,807(+) CTCCC(A/T)GAAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RAI14 Gene

Variant ID Type Subtype PubMed ID
dgv1090e214 CNV gain 21293372
dgv5629n100 CNV gain 25217958
dgv9717n54 CNV gain+loss 21841781
dgv9718n54 CNV gain 21841781
dgv9719n54 CNV loss 21841781
dgv9720n54 CNV loss 21841781
esv24799 CNV loss 19812545
esv26730 CNV loss 19812545
esv3575835 CNV gain 25503493
esv3604679 CNV gain 21293372
esv3604684 CNV gain 21293372
nsv4786 CNV insertion 18451855
nsv4787 CNV insertion 18451855
nsv519240 CNV gain 19592680
nsv522144 CNV loss 19592680
nsv597807 CNV loss 21841781
nsv830260 CNV gain 17160897

Variation tolerance for RAI14 Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.00; 93.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAI14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAI14 Gene

Disorders for RAI14 Gene

Relevant External Links for RAI14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RAI14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAI14 Gene

Publications for RAI14 Gene

  1. Cell density-dependent nuclear/cytoplasmic localization of NORPEG (RAI14) protein. (PMID: 16729964) Kutty R.K. … Wiggert B. (Biochem. Biophys. Res. Commun. 2006) 3 4 22 64
  2. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. (PMID: 11042181) Kutty R.K. … Wiggert B. (J. Biol. Chem. 2001) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study. (PMID: 19454037) Arnett D.K. … Broeckel U. (BMC Med. Genet. 2009) 3 46 64
  5. Expression of a novel alternative transcript of the novel retinal pigment epithelial cell gene NORPEG in human testes. (PMID: 16110356) Yuan W. … Sha J.-H. (Asian J. Androl. 2005) 3 4 64

Products for RAI14 Gene

Sources for RAI14 Gene

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