RAG2 Gene
protein-coding GIFtS: 59
GCID: GC11M036613
|
|
recombination activating gene 2
| |
Aliases
for RAG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Recombination Activating Gene 21 2 | | RAG-22 3 | | V(D)J Recombination-Activating Protein 22 |
Export aliases for RAG2 gene to outside databasesPrevious GC identifers: GC11M038170 GC11M037290 GC11M036652 GC11M036577 GC11M036570 GC11M036316 |
Summaries
for RAG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAG2:
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex canform double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activatinggene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombinationactivating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a bindingscaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in thisprotein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated atlysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated withautoimmune-like symptoms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895Function: Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)Jrecombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes indeveloping B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J(joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the topstrand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond onthe opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactionsand the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps.The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a singleimmunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor(BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulinallele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventingaccessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalyticcomponent but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor ofchromatin state that recruits the RAG complex to H3K4me3 (By similarity)
|
Genomic Views
for RAG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAG2 gene promoter:
AP-1 SREBP-1c ATF-2 Nkx2-5 NF-kappaB SREBP-1b SREBP-1a STAT3 c-Jun NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p12 HGNC cytogenetic band: 11p13RAG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M036613: view genomic region
(about GC identifiers)
Start:
|
36,597,124 bp from pter |
End:
|
36,619,829 bp from pter |
Size:
|
22,706 bases |
Orientation:
|
minus strand |
|
Proteins
for RAG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895 (See
protein sequence)Recommended Name: V(D)J recombination-activating protein 2 Size: 527 amino acids; 59241 Da
Subunit: Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 orHMGB2 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: A8K9E9 Q8TBL4Explore the universe of human proteins at neXtProt for RAG2: NX_P55895
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P55895
RAG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_000527.2 NP_001230714.1 NP_001230715.1
ENSEMBL proteins: ENSP00000308620 ENSP00000436327 ENSP00000436895 ENSP00000432174
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
NAS | -- |
RAG2 for ontologies About GeneDecksing
RAG2 Antibody Products:
Assay Products for RAG2: |
Protein
Domains /
Families
for RAG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAG2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P55895ProtoNet protein and cluster: P55895 1 Blocks protein family: IPB004321 V-D-J recombination activating protein 2 (RAG2)
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895Domain: The atypical PHD-type zinc finger recognizes and binds histone H3 trimethylated on 'Lys-4' (H3K4me3). Thepresence Tyr-445 instead of a carboxylate in classical PHD-type zinc fingers results in an enhanced binding to H3K4me3in presence of dimethylated on 'Arg-2' (H3R2me2) rather than inhibited. The atypical PHD-type zinc finger also bindsvarious phosphoinositides, such as phosphatidylinositol 3,4-bisphosphate binding (PtdIns(3,4)P2), phosphatidylinositol3,5-bisphosphate binding (PtdIns(3,5)P2), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) andphosphatidylinositol 3,4,5-trisphosphate binding (PtdIns(3,4,5)P3) (By similarity)Similarity: Belongs to the RAG2 familySimilarity: Contains 1 PHD-type zinc finger |
Function
for RAG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895Function: Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)Jrecombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes indeveloping B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J(joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the topstrand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond onthe opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2blunt, 5'-phosphorylated ends. The chromatin structure plays an essential role in the V(D)J recombination reactionsand the presence of histone H3 trimethylated at 'Lys-4' (H3K4me3) stimulates both the nicking and haipinning steps.The RAG complex also plays a role in pre-B cell allelic exclusion, a process leading to expression of a singleimmunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor(BCR) expressed on individual B-lymphocytes. The introduction of DNA breaks by the RAG complex on one immunoglobulinallele induces ATM-dependent repositioning of the other allele to pericentromeric heterochromatin, preventingaccessibility to the RAG complex and recombination of the second allele. In the RAG complex, RAG2 is not the catalyticcomponent but is required for all known catalytic activities mediated by RAG1. It probably acts as a sensor ofchromatin state that recruits the RAG complex to H3K4me3 (By similarity) Genatlas biochemistry entry for RAG2:recombination V(D)J activating gene 2,acting,in conjunction with RAG1,at a pair of recombination signal sequences andmaking double strand breaks,next to these signals,located 8kb apart from RAG1,convergently oriented
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAG2 |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
RAG2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAG2:
Animal Models:
Mouse knock-outs for RAG2: Rag2tm1Libo Rag2tm1.1Cgn Rag2tm1Fwa Rag2tm1.1Flv
15/19 MGI mutant phenotypes (inferred from 13 alleles ) (MGI details for Rag2) (see all 19):
RAG2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | C-MYB transcription factor network | | | 2 | Primary immunodeficiency | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for RAG2
1 
Kegg Pathway (Kegg details for RAG2):
RAG2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 12)
5/12 Interacting proteins for RAG2 (P558953 ENSP000003086204) via UniProtKB, MINT, STRING, and/or I2D (see all 12)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002326 | B cell lineage commitment |
IEA | -- | | GO:0002331 | pre-B cell allelic exclusion |
ISS | -- | | GO:0002358 | B cell homeostatic proliferation |
IEA | -- | | GO:0002360 | T cell lineage commitment |
IEA | -- | | GO:0016445 | somatic diversification of immunoglobulins |
NAS | -- |
RAG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for RAG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAG2 for compounds About GeneDecksing
 Browse Tocris compounds for RAG2
6 Novoseek chemical compound relationships for RAG2 gene About this table
Search CenterWatch for drugs/clinical trials and news about RAG2
|
Transcripts
for RAG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAG2 gene (3 alternative transcripts): NM_000536.3 NM_001243785.1 NM_001243786.1 Unigene Cluster for RAG2: Recombination activating gene 2 Hs.714519 [show with all ESTs]Unigene Representative Sequence: NM_0012437868 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524423 ENST00000311485(uc021qgc.1 uc021qgd.1 uc001mwv.4)
ENST00000529083 ENST00000527033 ENST00000532616 ENST00000534379 ENST00000528428
ENST00000530276
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAG2 (NM_000536) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAG2 |
Additional cDNA sequence: AF080577.1 AK292664.1 BC022397.1 S78372.1 6 DOTS entries: DT.75178642 DT.91970703 DT.91660697 DT.120734403 DT.100783792 DT.120734378 17 AceView cDNA sequences: BM463455 BG389099 S78372 AF080577 AW629088 BQ421024 BE247400 NM_000536 BC022397 BG612991 BG503568 BM457214 BE247239 T25429 AW058148 BG387433 T25437
GeneLoc Exon Structure
|
Expression
for RAG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGATGGGCA
About this image
See RAG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAG2
SOURCE GeneReport for Unigene cluster: Hs.714519
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895Tissue specificity: Cells of the B- and T-lymphocyte lineages
SABiosciences Custom PCR Arrays for RAG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAG2 |
Orthologs
for RAG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for RAG2 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for RAG2 (if available)
TreeFam Gene Tree for RAG2 (if available) |
Paralogs
for RAG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for RAG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAG2 (36597124 - 36619829 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAG2
1 CNV: 5274
Human Gene Mutation Database (HGMD): RAG2
Locus Specific Mutation Databases (LSDB): RAG2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAG2 |
|
Disorders
/ Diseases
for RAG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAG2 for disorders About GeneDecksing
OMIM gene information: 179616
OMIM disorders: 601457 603554 233650
UniProtKB/Swiss-Prot: RAG2_HUMAN, P55895
Defects in RAG2 are a cause of combined cellular and humoral immune defects with granulomas (CHIDG)[MIM:233650]. CHIDG is an immunodeficiency disease with granulomas in the skin, mucous membranes, and internal organs.Other characteristics include hypogammaglobulinemia, a diminished number of T and B-cells, and sparse thymic tissue onultrasonography Defects in RAG2 are a cause of severe combined immunodeficiency autosomal recessiveT-cell-negative/B-cell-negative/NK-cell-positive (T(-)B(-)NK(+) SCID) [MIM:601457]. A form of severe combinedimmunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterizedby impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patientspresent in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all typesof SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development Defects in RAG2 are a cause of Omenn syndrome (OS) [MIM:603554]. OS is a severe immunodeficiency characterizedby the presence of activated, anergic, oligoclonal T-cells, hypereosinophilia, and high IgE levels
20/30  diseases for RAG2 (see all 30): About MalaCardssevere combined immunodeficiency omenn syndrome combined immunodeficiency combined cellular and humoral immune defects with granulomas
immunodeficiency anaplastic large cell lymphoma artemis deficiency infectious mononucleosis
systemic lupus erythematosus lupus erythematosus ataxia telangiectasia herpes simplex
cutaneous t cell lymphoma lymphopenia was-related disorders leukopenia
multiple myeloma tonsillitis hepatitis b conjunctivitis
3 diseases from the University of Copenhagen DISEASES database for RAG2:Omenn syndrome Severe combined immunodeficiency Inflammatory bowel disease 10/12 Novoseek disease relationships for RAG2 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| omenn syndrome |
92.6 |
16 |
10226883 (2), 11313270 (1), 11908269 (1), 15025726 (1) (see all 15) |
| severe combined immunodeficiency |
75.6 |
9 |
15025726 (1), 15845893 (1), 20128425 (1), 14726805 (1) (see all 9) |
| immunodeficiency |
35.5 |
10 |
10891502 (2), 1428003 (1), 11908269 (1), 15640693 (1) (see all 9) |
| leukemia |
20.9 |
2 |
12393742 (1), 15611260 (1) |
| leukemia t-cell |
15.7 |
1 |
17059760 (1) |
| lymphoma |
14.6 |
3 |
7873997 (1), 11279609 (1), 16982894 (1) |
| autoimmune thyroid disease |
11.5 |
1 |
8077352 (1) |
| hodgkin disease |
10.5 |
1 |
1450411 (1) |
| tumors |
4.3 |
9 |
11372175 (3), 18987320 (1), 8892673 (1), 19779066 (1) (see all 6) |
| cancer |
1.33 |
5 |
14521728 (1), 17174398 (1), 18682256 (1), 17475920 (1) (see all 5) |
Human Genome Epidemiology (HuGE) Navigator: RAG2 (7 documents)
Export disorders for RAG2 gene to outside databases
|
Publications
for RAG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAG2 gene, integrated from 9 sources (see all 232):
(articles sorted by number of sources associating them with RAG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Expression of human recombination activating genes (RAG1 and RAG2) in neoplastic lymphoid cells: correlation with cell differentiation and antigen receptor expression. (PubMed id 1832998)1, 2, 9 Bories J.C.... Sigaux F. (1991)
- Sequence and chromosome assignment to 11p13-p12 of human RAG genes. (PubMed id 1428003)1, 2, 9 Ichihara Y.... Kurosawa Y. (1992)
- Human RAG2, like RAG1, is on chromosome 11 band p13 a nd therefore not linked to ataxia telangiectasia complementation groups. (PubMed id 1283330)1, 3, 9 Sherrington P.D....Rabbitts T.H. (1992)
- Partial V(D)J recombination activity leads to Omenn syndrome. (PubMed id 9630231)1, 2, 9 Villa A....Spanopoulou E. (1998)
- An immunodeficiency disease with RAG mutations and granulomas. (PubMed id 18463379)1, 2 Schuetz C....Niehues T. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- RAG mutations in human B cell-negative SCID. (PubMed id 8810255)1, 2 Schwarz K.... Bartram C.R. (1996)
- Overlapping signals for protein degradation and nuclear localization define a role for intrinsic RAG-2 nuclear uptake in dividing cells. (PubMed id 12861017)1, 9 Ross A.E....Desiderio S. (2003)
- RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. (PubMed id 11123315)1, 9 Girschick H.J....Lipsky P.E. (2001)
- RAG1 and RAG2 expression in human intestinal epithelium: evidence of extrathymic T cell differentiation. (PubMed id 7774617)1, 9 Lynch S....O'Farrelly C. (1995)
|
External Searches for RAG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAG2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for RAG2 | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for RAG2 | Genetics and Cytogenetics in Oncology and Haematology | | RAG2base | http://bioinf.uta.fi/RAG2base/ | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/RAG2 |
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About This Section
| Patent Information for RAG2 gene:
Search GeneIP for patents involving RAG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for RAG2 | | OriGene shRNA RFP for RAG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAG2 | | | OriGene Protein Over-expression Lysate for RAG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAG2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAG2 | | OriGene Custom Protein Services for RAG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAG2 |
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| | | | Search Tocris compounds for RAG2 |
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 | | | RAG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAG2 |
|  |  |  | | | | ThermoFisher Antibody for RAG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAG2 |
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