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RAF1 Gene

protein-coding GIFtS: 75

GC03M012600

v-raf-1 murine leukemia viral oncogene homolog 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-RAF ^³
CRAF ^¹, ², ⁵
EC 2.7.11.1 ^³
NS5 ^², ⁵
RAF ^³
Raf-1 ^¹, ², ³
c-Raf ^¹, ²
cRaf ^³

Descriptions
Oncogene RAF1 ^²
raf proto-oncogene serine/threonine protein kinase ^²
v-raf-1 murine leukemia viral oncogene homolog 1 ^²

External Ids
HGNC: 9829¹
Entrez Gene: 5894²
UniProtKB: P04049³
Ensembl: ENSG00000132155⁷

Search outside databases for aliases for RAF1 gene

Previous GC identifer: GC03M012554

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAF1:

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase

kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases

to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to

activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to

activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are

pleiotropic effectors of cell physiology and play an important role in the control of gene

expression involved in the cell division cycle, apoptosis, cell differentiation and cell

migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

[provided by RefSeq]

UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from

apoptosis mediated by STK3

Gene Wiki entry for RAF1 (C-Raf)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAF1 gene

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25

RAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M012600: (about GC identifiers)

Start:	12,600,108 bp from pter
End:	12,680,678 bp from pter
Size:	80,571 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049 (See protein sequence)

Recommended Name: RAF proto-oncogene serine/threonine-protein kinase

Size: 648 amino acids; 73052 Da

Cofactor: Binds 2 zinc ions per subunit

Subunit: Interacts with Ras proteins; the interaction is antagonized by RIN1. Weakly interacts with

RIT1 (By similarity). Interacts with STK3; the interaction inhibits its pro-apoptotic activity.

Interacts with YWHAZ (unphosphorylated at 'Thr-232')

PDB structures from and Proteopedia :

1C1Y (3D)

1FAQ (3D)

1FAR (3D)

1GUA (3D)

1RFA (3D)

3CU8 (3D)

Secondary accessions: B0LPH8 B2R5N3 Q15278 Q9UC20

Alternative splicing: 2 isoforms: P04049-1 P04049-2

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylation at Thr-269 increases its

kinase activity¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002871.1

ENSEMBL proteins:

ENSP00000251849

Human Recombinant Proteins

	Invitrogen human recombinant proteins for RAF1
	Millipore Purified and/or Recombinant RAF1 Protein
	Sigma-Aldrich Proteins for RAF1
	R&D Systems Recombinant & Natural Proteins for RAF1 (Raf-1)
	Enzo Life Sciences proteins for RAF1
	Recombinant Proteins from Abcam (Raf1)
	Human Recombinant Proteins from Abnova (RAF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005741	mitochondrial outer membrane	TAS	8929532
GO:0005829	cytosol	EXP	9069260
GO:0005886	plasma membrane	EXP	9069260

About this table

Antibodies for RAF1:

	Invitrogen Antibodies for RAF1
	Millipore Mono- and Polyclonal Antibodies for the study of RAF1
	Sigma-Aldrich Antibody Arrays and Antibodies for RAF1
	R&D Systems Antibodies for RAF1 (Raf-1)
	Cell Signaling Technology (CST) Antibodies for RAF1 (c-Raf)
	Antibodies from Abcam (Raf1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for RAF1

Assays for RAF1:

	Invitrogen Assays for RAF1
	Millipore Kits and Assays for the Analysis of RAF1
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04049

ProtoNet protein and cluster: P04049

2 Blocks protein families:

IPB002219 Protein kinase C

IPB003116 Raf-like Ras-binding

UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049

Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF

subfamily

Similarity: Contains 1 phorbol-ester/DAG-type zinc finger

Similarity: Contains 1 protein kinase domain

Similarity: Contains 1 RBD (Ras-binding) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAF1)
		Millipore RNAi Products for the Analysis of RAF1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RAF1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002880

Applied Biosystems Silencer® siRNAs for RAF1

Sigma-Aldrich siRNA and siRNA Panels for RAF1

Sigma-Aldrich shRNA Panels and shRNA for RAF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002880
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002880
untagged cDNA clones in CMV expression vector (see all 5): NM_002880

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002880

UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049

Function: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

Part of the Ras-dependent signaling pathway from receptors to the nucleus. Protects cells from

apoptosis mediated by STK3

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for RAF1:

murine sarcoma viral (v-raf-1) oncogene homolog 1 (mitogenic factor) interacting with TC21 for

activation and translocation to plasma membrane

14 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Raf1):

	cellular	embryogenesis	growth/size	hematopoietic system
lethality-postnatal	lethality-prenatal/perinatal	liver/biliary system	muscle	nervous system
normal	respiratory system	skin/coat/nails	vision/eye

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005515	protein binding	IPI	9624170 10433554
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/80 Sigma-Aldrich "Your Favorite Gene" Pathways for RAF1 (Your Favorite Gene powered by Ingenuity) (see all 80 )

Natural Killer Cell Signaling
fMLP Signaling in Neutrophils
Melanoma Signaling
Melatonin Signaling
Thrombopoietin Signaling

GeneDecks RAF1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RAF1

5/184 Interacting proteins for RAF1 (P04049^{1, 2} ENSP00000251849³) via UniProtKB, MINT, and/or STRING (see all 184 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PEBP1	P30086², ENSP00000261313³	MINT-3389495 MINT-3389468 MINT-3389522 MINT-3389581 MINT-3389607 MINT-3389378 MINT-3389550 STRING (score=.999)
PEBP4	Q96S96², ENSP00000256404³	MINT-7014142 MINT-7014406 MINT-7014294 MINT-7014315 MINT-7014341 STRING (score=.771)
BAG1	Q99933², ENSP00000224112³	MINT-45862 MINT-45863 STRING (score=.981)
YWHAB	P31946¹, ENSP00000361930³	EBI-365996, EBI-359815 STRING (score=.999)
PAK1	Q13153², ENSP00000278568³	MINT-3389399 STRING (score=.996)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein amino acid phosphorylation	TAS	8063729
GO:0006915	apoptosis	TAS	8929532
GO:0007010	cytoskeleton organization	IEA	--
GO:0007265	Ras protein signal transduction	EXP	11520933
GO:0008283	cell proliferation	TAS	8063729

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for RAF1:

Inhibitor

Compounds for RAF1 available from Tocris Bioscience

Compound	Action	CAS number
ZM 336372	Potent, selective c-Raf inhibitor	[208260-29-1]
GW 5074	Potent, selective c-Raf1 kinase inhibitor	[220904-83-6]
L-779,450	Potent Raf kinase inhibitor	[303727-31-3]

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10/40 Novoseek chemical compound relationships for RAF1 gene (see all 40 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gw-5074	86.72	15	15255937 (3), 16440327 (2), 19288477 (2), 16546979 (1) (see all 10)
zm 336372	83.29	15	18063082 (3), 16603190 (2), 15956248 (2), 16909118 (1) (see all 5)
threonine	80.64	135	9689060 (3), 7803760 (3), 7685905 (2), 1461284 (2) (see all 99)
tyrosine	77.29	264	8622647 (5), 8662746 (5), 7692235 (5), 7542586 (4) (see all 99)
pd 98,059	75.81	25	12389631 (2), 10727406 (1), 11703098 (1), 14736735 (1) (see all 19)
17-(allylamino)-17-demethoxygeldanamycin	74.80	8	9622079 (1), 11280726 (1), 14506167 (1), 18281495 (1) (see all 5)
phosphatidylinositol	67.68	70	10801448 (5), 10712905 (5), 16331688 (3), 17332339 (2) (see all 40)
12-o-tetradecanoylphorbol 13-acetate	62.51	57	16169661 (4), 8195229 (3), 11257453 (3), 1437148 (3) (see all 25)
adaphostin	62.09	4	16166589 (2), 14647418 (1), 16481037 (1)
gtp	55.44	29	7623807 (2), 9199317 (2), 8576262 (2), 7604263 (2) (see all 19)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAF1)
		Millipore RNAi Products for the Analysis of RAF1 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RAF1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002880

Sigma-Aldrich siRNA and siRNA Panels for RAF1

Sigma-Aldrich shRNA Panels and shRNA for RAF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002880

REFSEQ mRNAs for RAF1 gene:

NM_002880.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002880

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002880
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002880
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_002880

Additional cDNA sequence:

AK055589.1 AK124449.1 AK226028.1 AK303561.1 AK303920.1 AK312248.1 BC018119.2 BX648063.1

CR598160.1 CR608506.1 CR609564.1 CR616511.1 CR617502.1 X03484.1

20 DOTS entries:

DT.100669838 DT.100669840 DT.100669848 DT.87008986 DT.91838878 DT.75151772 DT.95278225 DT.95278214

DT.100669835 DT.91705198 DT.120918106 DT.91993563 DT.100690754 DT.120918099 DT.120918136 DT.91695943

DT.92451812 DT.40190406 DT.91826781 DT.95337142

24/551 AceView cDNA sequences (see all 551 ):

BQ681059 CD513500 CR617502 AA357046 BQ221403 CR608506 BM509572 BQ431831

BP363298 BQ682769 CN479413 BQ892795 BQ677395 H92852 CR609564 BM562649

BU196606 BM683631 BQ188721 AL042845 CR598160 BM770596 BQ684667 AI151178

highest scoring ESTs for RAF1:

X03484 AL120772 AL517435 AL526360 AU129992 AU130456 AV685273 AV686392 BC018119 BE244097

Unigene Cluster for RAF1:

V-raf-1 murine leukemia viral oncogene homolog 1

Hs.159130 [show with all ESTs]

Unigene Representative Sequence: NM_002880

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000251849

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAF1

¹ / ² / ³

4 probe-sets matching RAF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38743_f_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.04	X06409	0.40	1.00	0.76	1
1917_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.96	X03484	1.00	1.00	1.00	1
201244_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002880	0.60	1.00	0.82	1
201244_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTATACAAG

SOURCE GeneReport for Unigene cluster: Hs.159130
Expression variation in blood from EXPOLDB for RAF1
UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049
Tissue specificity: In skeletal muscle, isoform 1 is more abundant than isoform 2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAF1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAF1¹	--	v-raf-1 murine leukemia viral oncogene homolog 1	92.54(n) 98.77(a)	484648 XM_541762.2 XP_541762.2
chimpanzee (Pan troglodytes)	RAF1¹	--	v-raf-1 murine leukemia viral oncogene homolog 1	99.74(n) 99.85(a)	460182 XM_001155232.1 XP_001155232.1
rat (Rattus norvegicus)	Raf1¹	--	v-raf-leukemia viral oncogene 1	90.84(n) 98.3(a)	24703 NM_012639.2 NP_036771.1
mouse (Mus musculus)	Raf1^{1, 5}	6 (52.50 cM)⁵	v-raf-leukemia viral oncogene 1^{1, 5}	90.79(n)¹ 97.69(a)¹	110157¹ NM_029780.3¹ NP_084056.1¹ AA990557⁵ AB052739⁵ (see all 27)
chicken (Gallus gallus)	RAF1¹	--	v-raf-1 murine leukemia viral oncogene homolog 1	81.5(n) 94.74(a)	396245 NM_205307.1 NP_990638.1

About this table Species with no ortholog for RAF1

ENSEMBL Gene Tree for RAF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAF1 gene

ARAF² BRAF²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/678 NCBI SNPs in RAF1 are shown (see all 678 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 178)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3806661^1,2	A,C,F,H	12680855(-)	`GTGCCT/CCTCCT`	1	--	ng3¹		4		EU EA WA	412
	rs5746220^1,2	C,F,H	12616718(-)	`ACAGCC/TGAAAA`	1	P/L	mis¹ ese³		5		NS EU EA WA	572
	rs1051208^1,2	C,F,H	12600747(-)	`AGATGC/TGCAAG`	1	--	ut3¹ ese³		19		NS MN NA EA EU WA	1912
	rs2229757^1,2	C,F	12600930(-)	`AGAGGC/TAGAAC`	1	--	ut3¹ ese³		8		MN NS	866
--	rs9861271^1,2	A,C	12682620(+)	`AACATA/CATGTA`	1	--	ng3¹		0	--	--	--	--
--	rs7633300^1,2	A,C	12682573(+)	`tctgtC/Tgcaaa`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs5746246^1,2	C,F	12600853(-)	`GCCTTC/TTTTTC`	1	--	ut3¹ trp³		7		NS	818
--	rs9860631^1,2	C	12682229(+)	`acagtA/Gaaacc`	1	--	ng3¹		0	--	--	--	--
	rs3730271^1,2	H	12620694(-)	`CGACAT/CCCACA`	1	P/S	mis¹		4		EU EA WA	406
--	rs13069726^1,2	A	12681648(+)	`tggcgG/Tgcgcc`	1	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for RAF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 164760 disorders: 611553 611554

UniProtKB/Swiss-Prot: RAF1_HUMAN, P04049

Defects in RAF1 are the cause of Noonan syndrome type 5 (NS5) [MIM:611553]. Noonan

syndrome (NS) is a disorder characterized by dysmorphic facial features, short stature,

hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a

genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in

1000-2500 live births

Defects in RAF1 are the cause of LEOPARD syndrome type 2 (LEOPARD syndrome-2)

[MIM:611554]. LEOPARD syndrome is an autosomal dominant disorder allelic with Noonan syndrome. The

acronym LEOPARD stands for lentigines, electrocardiographic conduction abnormalities, ocular

hypertelorism, pulmonic stenosis, abnormalities of genitalia, retardation of growth, and deafness

10/82 Novoseek disease relationships for RAF1 gene (see all 82 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	53.70	68	12781369 (3), 18221149 (2), 17555829 (2), 16170185 (2) (see all 54)
tumors	51.89	176	16926634 (6), 8451761 (3), 15803144 (3), 10830717 (3) (see all 98)
viral leukemia	50.92	3	1783381 (1), 15845465 (1), 10449917 (1)
shock	46.15	27	9622079 (1), 11280726 (1), 14724288 (1), 15338192 (1) (see all 25)
leukemia	35.25	22	16250879 (3), 12903397 (3), 9632143 (2), 9242431 (1) (see all 14)
neuroendocrine tumors	33.61	3	12490852 (1), 8751579 (1), 16428931 (1)
myeloid leukemia	33.38	9	16883571 (1), 8288641 (1), 12536201 (1), 8207958 (1) (see all 6)
solid tumor	31.83	4	15585643 (1), 16498671 (1), 16890795 (1)
melanoma	31.76	16	17018604 (3), 17699719 (2), 14654778 (2), 19052265 (2) (see all 10)
noonan syndrome	31.21	3	17603483 (2), 18064648 (1)

About this table

GeneTests: RAF1

LEOPARD Syndrome

Human Gene Mutation Database: RAF1
Human Genome Epidemiology Navigator: RAF1 (5 documents)
Tumor Gene Database: RAF1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1287 PubMed articles for RAF1 gene (see all 1287 ):

Phosphorylation of Raf by ceramide-activated protein kinase. (PubMed id 7477354)^{1, 3, 4} Yao B.... Kolesnick R. (1995)
Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. (PubMed id 17603483)^{1, 3, 4} Pandit B....Gelb B.D. (2007)
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. (PubMed id 9823899)^{1, 3, 4} King A.J....Marshall M.S. (1998)
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site. (PubMed id 8710867)^{1, 3, 4} Mott H.R....Campbell S.L. (1996)
Germline gain-of-function mutations in RAF1 cause Noonan syndrome. (PubMed id 17603482)^{3, 4} Razzaque M.A....Matsuoka R. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Role of the kinase MST2 in suppression of apoptosis by the proto- oncogene product Raf-1. (PubMed id 15618521)^{3, 4} O'Neill E.... Kolch W. (2004)
The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. (PubMed id 11784866)^{3, 4} Wang Y....Colicelli J. (2002)
Ras/Rap effector specificity determined by charge reversal. (PubMed id 8756332)^{3, 4} Nassar N....Wittinghofer A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5894	HGNC: 9829	AceView: RAF1	Ensembl:ENSG00000132155	euGenes: HUgn5894
ECgene: RAF1	H-InvDB: RAF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAF1	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.genetests.org/query?gene=RAF1
NIEHS-SNPs	http://egp.gs.washington.edu/data/raf1/

Licensable Technologies for RAF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAF1		Antibodies for RAF1
	Explore super-pooled esiRNAs		Proteins for RAF1
	Lentivirus-delivered shRNAs for RAF1		Small molecules for RAF1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAF1)
	Search for Antibodies
	Chimera RNAi (RAF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for RAF1 (c-Raf)

	Recombinant Proteins (Raf1)
	Antibodies (Raf1)

Search OriGene for RAF1

Tocris compounds for RAF1

	Proteins for RAF1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAF1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RAF1 Gene at Home site.
Version 2.41.1
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RAF1 Gene

protein-coding GIFtS: 75

Aliases &
Descriptions
for RAF1

Summaries
for RAF1

Genomic Location
for RAF1

Proteins
for RAF1

Protein Domains/
Families
for RAF1

Gene Function
for RAF1

Pathways & Interactions
for RAF1

Drugs & Compounds
for RAF1

Transcripts
for RAF1

Expression
for RAF1

Orthologs
for RAF1

Paralogs
for RAF1

SNPs/Variants
for RAF1

Disorders & Mutations
for RAF1

Medical News
for RAF1

Publications
for RAF1

Search for RAF1

Genome Databases showing RAF1

Other Databases showing RAF1

Specialized Databases showing RAF1

Licensable Technologies
for RAF1

Services
for RAF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAF1 Gene

protein-coding GIFtS: 75

Aliases & Descriptionsfor RAF1

Summariesfor RAF1

Genomic Locationfor RAF1

Proteinsfor RAF1

Protein Domains/Familiesfor RAF1

Gene Functionfor RAF1

Pathways & Interactionsfor RAF1

Drugs & Compoundsfor RAF1

Transcriptsfor RAF1

Expression for RAF1

Orthologsfor RAF1

Paralogsfor RAF1

SNPs/Variantsfor RAF1

Disorders & Mutationsfor RAF1

Medical Newsfor RAF1

Publicationsfor RAF1

Search for RAF1

Genome Databases showing RAF1

Other Databases showing RAF1

Specialized Databases showing RAF1

Licensable Technologiesfor RAF1

Servicesfor RAF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAF1

Summaries
for RAF1

Genomic Location
for RAF1

Proteins
for RAF1

Protein Domains/
Families
for RAF1

Gene Function
for RAF1

Pathways & Interactions
for RAF1

Drugs & Compounds
for RAF1

Transcripts
for RAF1

Expression
for RAF1

Orthologs
for RAF1

Paralogs
for RAF1

SNPs/Variants
for RAF1

Disorders & Mutations
for RAF1

Medical News
for RAF1

Publications
for RAF1

Licensable Technologies
for RAF1

Services
for RAF1