Aliases for RAET1L Gene
External Ids for RAET1L Gene
Previous GeneCards Identifiers for RAET1L Gene
RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]
GeneCards Summary for RAET1L Gene
RAET1L (Retinoic Acid Early Transcript 1L) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Immune response Role of DAP12 receptors in NK cells. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.
UniProtKB/Swiss-Prot for RAET1L Gene
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.