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Aliases for RAET1L Gene

Aliases for RAET1L Gene

  • Retinoic Acid Early Transcript 1L 2 3
  • Retinoic Acid Early Transcript 1L Protein 3
  • UL16 Binding Protein 6 3
  • ULBP6 3

External Ids for RAET1L Gene

Previous GeneCards Identifiers for RAET1L Gene

  • GC06M149902
  • GC06M150236
  • GC06M150370
  • GC06M150372
  • GC06M150433
  • GC06M150339
  • GC06M147906

Summaries for RAET1L Gene

Entrez Gene Summary for RAET1L Gene

  • RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAET1L Gene

RAET1L (Retinoic Acid Early Transcript 1L) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1L Gene

Genomics for RAET1L Gene

Regulatory Elements for RAET1L Gene

Genomic Location for RAET1L Gene

150,018,334 bp from pter
150,025,532 bp from pter
7,199 bases
Minus strand

Genomic View for RAET1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAET1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1L Gene

Proteins for RAET1L Gene

  • Protein details for RAET1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinoic acid early transcript 1L protein
    Protein Accession:
    Secondary Accessions:
    • A3KME4
    • Q8TE74

    Protein attributes for RAET1L Gene

    246 amino acids
    Molecular mass:
    27509 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAET1L Gene

Proteomics data for RAET1L Gene at MOPED

Post-translational modifications for RAET1L Gene

  • Glycosylation at Asn68 and Asn82
  • Modification sites at PhosphoSitePlus

Other Protein References for RAET1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAET1L Gene

Domains for RAET1L Gene

Protein Domains for RAET1L Gene

Suggested Antigen Peptide Sequences for RAET1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5VY80
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1L: view

No data available for Gene Families for RAET1L Gene

Function for RAET1L Gene

Gene Ontology (GO) - Molecular Function for RAET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IBA --
genes like me logo Genes that share ontologies with RAET1L: view

Phenotypes for RAET1L Gene

GenomeRNAi human phenotypes for RAET1L:
genes like me logo Genes that share phenotypes with RAET1L: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAET1L Gene

Localization for RAET1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1L Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for RAET1L Gene COMPARTMENTS Subcellular localization image for RAET1L gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with RAET1L: view

Pathways for RAET1L Gene

genes like me logo Genes that share pathways with RAET1L: view

Pathways by source for RAET1L Gene

1 KEGG pathway for RAET1L Gene

Interacting Proteins for RAET1L Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000286380 for RAET1L Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for RAET1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006955 immune response --
GO:0019882 antigen processing and presentation --
GO:0042267 natural killer cell mediated cytotoxicity IBA --
genes like me logo Genes that share ontologies with RAET1L: view

Transcripts for RAET1L Gene

mRNA/cDNA for RAET1L Gene

(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAET1L Gene

Retinoic acid early transcript 1L:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1L Gene

No ASD Table

Relevant External Links for RAET1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAET1L Gene

mRNA expression in normal human tissues for RAET1L Gene

mRNA differential expression in normal tissues according to GTEx for RAET1L Gene

This gene is overexpressed in Esophagus - Mucosa (30.0), Vagina (8.3), Minor Salivary Gland (5.0), and Cervix - Ectocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAET1L Gene

SOURCE GeneReport for Unigene cluster for RAET1L Gene Hs.558659

mRNA Expression by UniProt/SwissProt for RAET1L Gene

Tissue specificity: Widely expressed in non-hemopoietic and non-intestinal tissues.
genes like me logo Genes that share expressions with RAET1L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RAET1L Gene

Orthologs for RAET1L Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 91 (a)
-- 36
  • 94 (a)
  • 96.9 (n)
  • 93.81 (a)
(Bos Taurus)
Mammalia -- 36
  • 35 (a)
-- 36
  • 42 (a)
-- 36
  • 41 (a)
-- 36
  • 52 (a)
-- 36
  • 41 (a)
-- 36
  • 33 (a)
ULBP27 36
  • 40 (a)
ULBP3 36
  • 33 (a)
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
Species with no ortholog for RAET1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1L Gene

Gene Tree for RAET1L (if available)
Gene Tree for RAET1L (if available)

Paralogs for RAET1L Gene

Paralogs for RAET1L Gene Pseudogenes for RAET1L Gene

genes like me logo Genes that share paralogs with RAET1L: view

Variants for RAET1L Gene

Sequence variations from dbSNP and Humsavar for RAET1L Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs561467 -- 150,020,782(+) CCCGA(C/T)GAGGA intron-variant
rs561472 -- 150,020,775(+) AGGAG(C/G)GCCCG intron-variant
rs561526 -- 150,020,760(+) GCCAG(C/T)AACCC intron-variant
rs912565 - 150,022,075(+) AGGCC(A/G)TTGTG missense, reference
rs1543547 - 150,025,396(+) TCGCC(C/T)AGCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for RAET1L Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
esv2732866 CNV Deletion 23290073
esv2732878 CNV Deletion 23290073
esv7375 CNV Loss 19470904
esv2678333 CNV Deletion 23128226
esv2732879 CNV Deletion 23290073
dgv7008n71 CNV Loss 21882294
nsv886767 CNV Gain 21882294
nsv464077 CNV Loss 19166990
nsv5535 CNV Loss 18451855
nsv886769 CNV Loss 21882294

Relevant External Links for RAET1L Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1L Gene

Disorders for RAET1L Gene

Relevant External Links for RAET1L

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAET1L: view

No data available for UniProtKB/Swiss-Prot for RAET1L Gene

Publications for RAET1L Gene

  1. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M. … Bahram S. (Genomics 2002) 2 3 4
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 48
  3. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 48
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3
  5. The genotype of RAET1L (ULBP6), a ligand for human NKG2D (KLRK1), markedly influences the clinical outcome of allogeneic stem cell transplantation. (PMID: 23025544) Antoun A. … Moss P. (Br. J. Haematol. 2012) 3

Products for RAET1L Gene

Sources for RAET1L Gene

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