RAET1L Gene
protein-coding GIFtS: 46
GCID: GC06M150339
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retinoic acid early transcript 1L
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Aliases
for RAET1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoic Acid Early Transcript 1L1 2 | | ULBP62 | | Retinoic Acid Early Transcript 1L Protein2 | | UL16 Binding Protein 62 |
Export aliases for RAET1L gene to outside databasesPrevious GC identifers: GC06M149902 GC06M150236 GC06M150370 GC06M150372 GC06M150433 GC06M147906 |
Summaries
for RAET1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAET1L:
RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are locatedwithin a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellularalpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins areanchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 (PubMed11827464)).(supplied by OMIM, Mar 2008)
|
Genomic Views
for RAET1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAET1L gene promoter:
Elk-1 AML1a NF-YA Nkx5-1 NF-YB CBF-A CBF-B CP1A NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAET1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAET1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q24.1-25.1RAET1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M150339: view genomic region
(about GC identifiers)
Start:
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150,339,470 bp from pter |
End:
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150,346,668 bp from pter |
Size:
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7,199 bases |
Orientation:
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minus strand |
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Proteins
for RAET1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RET1L_HUMAN, Q5VY80 (See
protein sequence)Recommended Name: Retinoic acid early transcript 1L protein precursor Size: 246 amino acids; 27509 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (By similarity)
Secondary accessions: A3KME4 Q8TE74Explore the universe of human proteins at neXtProt for RAET1L: NX_Q5VY80
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VY80
RAET1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_570970.2
ENSEMBL proteins: ENSP00000356310 ENSP00000286380
Human Recombinant Protein Products for RAET1L:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0031225 | anchored to membrane |
IEA | -- | | GO:0042612 | MHC class I protein complex |
IEA | -- |
RAET1L for ontologies About GeneDecksing
RAET1L Antibody Products:
Assay Products for RAET1L: |
Protein
Domains /
Families
for RAET1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAET1L for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VY80ProtoNet protein and cluster: Q5VY80 UniProtKB/Swiss-Prot: RET1L_HUMAN, Q5VY80Similarity: Belongs to the MHC class I family |
Function
for RAET1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for RAET1L:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAET1L (NM_130900) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAET1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1L |
|
Pathways & Interactions
for RAET1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Natural killer cell mediated cytotoxicity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for RAET1L):
RAET1L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAET1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for RAET1L (ENSP000002863804) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
IEA | -- | | GO:0019882 | antigen processing and presentation |
IEA | -- |
RAET1L for ontologies About GeneDecksing
|
Drugs & Compounds
for RAET1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAET1L
Search CenterWatch for drugs/clinical trials and news about RAET1L / RET1L
|
Transcripts
for RAET1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAET1L gene: NM_130900.2 Unigene Cluster for RAET1L: Retinoic acid early transcript 1L Hs.558659 [show with all ESTs]Unigene Representative Sequence: NM_1309002 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367341 ENST00000286380(uc011eei.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAET1L (NM_130900) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAET1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1L |
Additional cDNA sequence: AY039682.1 BC131600.1 1 DOTS entry: DT.97834669 5 AceView cDNA sequences: NM_130900 AY039682 BX504984 AW238299 BU624913
GeneLoc Exon Structure
|
Expression
for RAET1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAET1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCTCAGGCA
About this image
See RAET1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.558659
UniProtKB/Swiss-Prot: RET1L_HUMAN, Q5VY80Tissue specificity: Widely expressed in non-hemopoietic and non-intestinal tissues
SABiosciences Custom PCR Arrays for RAET1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAET1L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat RAET1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAET1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAET1L |
Orthologs
for RAET1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RAET1L (if available)
TreeFam Gene Tree for RAET1L (if available) |
Paralogs
for RAET1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAET1L gene
- ULBP12 RAET1G2 ULBP32 RAET1E2 ULBP22
18 SIMAP similar genes for RAET1L using alignment to 6 protein entries: RET1L_HUMAN (see all proteins):ULBP2 RAET1H RAET1G ULBP3 ULBP1 RAET-1E
RAET1E HLA C* HLA-Cw HLA-A*03 HLA-Cw*15P HLA-G
HLA-B HLA-C HLA B HLA-A*24 HLA-B*47RG HLA-B52
RAET1L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for RAET1L
PGOHUM00000243819
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Genomic Variants
for RAET1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAET1L (150339470 - 150346668 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAET1L
1 CNV: 62586
Human Gene Mutation Database (HGMD): RAET1L
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAET1L |
|
Disorders
/ Diseases
for RAET1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAET1L for disorders About GeneDecksing
OMIM gene information: 611047
OMIM disorders: --
2  diseases for RAET1L: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: RAET1L (4 documents)
Export disorders for RAET1L gene to outside databases
|
Publications
for RAET1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAET1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAET1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 2, 3 Radosavljevic M.... Bahram S. (2002)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evi dence of diversity between human populations. (PubMed id 20219610)1 Antoun A....Briggs D.C. (2010)
- Polymorphisms of NKG2D ligands: diverse RAET1/ULBP ge nes in northeastern Thais. (PubMed id 19688209)1 Romphruk A.V....Leelayuwat C. (2009)
- ULBP6/RAET1L is an additional human NKG2D ligand. (PubMed id 19658097)1 Eagle R.A....Trowsdale J. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RAET1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing RAET1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAET1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAET1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RAET1L | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RAET1L gene:
Search GeneIP for patents involving RAET1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAET1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAET1L | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAET1L | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAET1L | | | OriGene Protein Over-expression Lysate for RAET1L | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAET1L | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1L | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAET1L | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAET1L | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAET1L | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAET1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAET1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAET1L |
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 |  |  |  | |
| | | | Search Tocris compounds for RAET1L |
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 | | | RAET1L Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for RAET1L |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1L |
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