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Aliases for RAET1G Gene

Aliases for RAET1G Gene

  • Retinoic Acid Early Transcript 1G 2 3 5
  • UL-16 Binding Protein 5 3 4
  • ULBP5 3 4
  • Retinoic Acid Early Transcript 1G Pseudogene 2

External Ids for RAET1G Gene

Previous GeneCards Identifiers for RAET1G Gene

  • GC06U900331
  • GC06M150323
  • GC06M150279
  • GC06M150238
  • GC06M147803

Summaries for RAET1G Gene

Entrez Gene Summary for RAET1G Gene

  • This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

GeneCards Summary for RAET1G Gene

RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Natural Killer Cell Receptors: Human Target Cell ?€“ NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for RAET1G Gene

  • Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1G Gene

Genomics for RAET1G Gene

Regulatory Elements for RAET1G Gene

Promoters for RAET1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAET1G on UCSC Golden Path with GeneCards custom track

Genomic Location for RAET1G Gene

Chromosome:
6
Start:
149,916,878 bp from pter
End:
149,923,152 bp from pter
Size:
6,275 bases
Orientation:
Minus strand

Genomic View for RAET1G Gene

Genes around RAET1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAET1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAET1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1G Gene

Proteins for RAET1G Gene

  • Protein details for RAET1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H3X3-RET1G_HUMAN
    Recommended name:
    Retinoic acid early transcript 1G protein
    Protein Accession:
    Q6H3X3
    Secondary Accessions:
    • Q6H3X2

    Protein attributes for RAET1G Gene

    Size:
    334 amino acids
    Molecular mass:
    37106 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16.

    Alternative splice isoforms for RAET1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1G Gene

Proteomics data for RAET1G Gene at MOPED

Post-translational modifications for RAET1G Gene

  • The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.
  • Glycosylation at Asn 82
  • Modification sites at PhosphoSitePlus

Other Protein References for RAET1G Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for RAET1G Gene

Domains & Families for RAET1G Gene

Protein Domains for RAET1G Gene

Graphical View of Domain Structure for InterPro Entry

Q6H3X3

UniProtKB/Swiss-Prot:

RET1G_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1G: view

No data available for Gene Families for RAET1G Gene

Function for RAET1G Gene

Molecular function for RAET1G Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAET1G Gene

Localization for RAET1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1G Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAET1G Gene COMPARTMENTS Subcellular localization image for RAET1G gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 3
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with RAET1G: view

Pathways & Interactions for RAET1G Gene

genes like me logo Genes that share pathways with RAET1G: view

Pathways by source for RAET1G Gene

Interacting Proteins for RAET1G Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356329%0d%0a9606.ENSP00000229708%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000455951%0d%0a
Selected Interacting proteins: ENSP00000356329 Q6H3X3-RET1G_HUMAN for RAET1G Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RAET1G Gene

None

No data available for SIGNOR curated interactions for RAET1G Gene

Drugs & Compounds for RAET1G Gene

No Compound Related Data Available

Transcripts for RAET1G Gene

mRNA/cDNA for RAET1G Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAET1G Gene

Retinoic acid early transcript 1G:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1G Gene

No ASD Table

Relevant External Links for RAET1G Gene

GeneLoc Exon Structure for
RAET1G
ECgene alternative splicing isoforms for
RAET1G

Expression for RAET1G Gene

mRNA expression in normal human tissues for RAET1G Gene

mRNA differential expression in normal tissues according to GTEx for RAET1G Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9) and Adrenal Gland (x9.5).

Protein differential expression in normal tissues from HIPED for RAET1G Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAET1G Gene



SOURCE GeneReport for Unigene cluster for RAET1G Gene Hs.558792

mRNA Expression by UniProt/SwissProt for RAET1G Gene

Q6H3X3-RET1G_HUMAN
Tissue specificity: Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.
genes like me logo Genes that share expression patterns with RAET1G: view

Protein tissue co-expression partners for RAET1G Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RAET1G Gene

Orthologs for RAET1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAET1G 35
  • 97.21 (n)
  • 94.91 (a)
-- 36
  • 86 (a)
ManyToMany
-- 36
  • 84 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RAET1G 36
  • 33 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 33 (a)
OneToMany
Species with no ortholog for RAET1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1G Gene

ENSEMBL:
Gene Tree for RAET1G (if available)
TreeFam:
Gene Tree for RAET1G (if available)

Paralogs for RAET1G Gene

Paralogs for RAET1G Gene

genes like me logo Genes that share paralogs with RAET1G: view

Variants for RAET1G Gene

Sequence variations from dbSNP and Humsavar for RAET1G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_033449 -
rs3922946 -- 149,924,781(+) CCTGC(A/G)GCCAT upstream-variant-2KB
rs3922947 -- 149,924,856(+) CAGAA(A/G)CCAGA upstream-variant-2KB
rs4869767 -- 149,923,974(+) TCAGA(A/G)GCTTC upstream-variant-2KB
rs4869768 -- 149,924,067(+) AAATT(A/G)TCTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAET1G Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv886765 CNV Gain 21882294
esv2732866 CNV Deletion 23290073

Variation tolerance for RAET1G Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAET1G Gene

HapMap Linkage Disequilibrium report
RAET1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1G Gene

Disorders for RAET1G Gene

Relevant External Links for RAET1G

Genetic Association Database (GAD)
RAET1G
Human Genome Epidemiology (HuGE) Navigator
RAET1G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAET1G

No disorders were found for RAET1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAET1G Gene

Publications for RAET1G Gene

  1. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L. … Trowsdale J. (J. Immunol. 2004) 2 3 4 23 67
  2. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23
  3. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. (PMID: 20304922) Ohashi M. … Trowsdale J. (J. Biol. Chem. 2010) 3 23
  4. Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain. (PMID: 19424970) Wittenbrink M. … Steinle A. (Eur. J. Immunol. 2009) 3 23
  5. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23

Products for RAET1G Gene

Sources for RAET1G Gene

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