RAET1G Gene
protein-coding GIFtS: 47
GCID: GC06M150238
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retinoic acid early transcript 1G(Previous name: retinoic acid early transcript 1G pseudogene )
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Aliases
for RAET1G gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Retinoic Acid Early Transcript 1G1 2 | | ULBP51 2 | | Retinoic Acid Early Transcript 1G Pseudogene1 2 | | Retinoic Acid Early Transcript 1G Protein2 |
Export aliases for RAET1G gene to outside databasesPrevious GC identifers: GC06U900331 GC06M150323 GC06M150279 GC06M147803 |
Summaries
for RAET1G gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAET1G:
Members of the RAET1 family, such as RAET1G, are major histocompatibility complex (MHC) class I-related genes locatedwithin a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2domains. RAET1E (MIM 609243) and RAET1G differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) inthat they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchorsequences. (Radosavljevic et al., 2002 (PubMed 11827464)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: RET1G_HUMAN, Q6H3X3Function: Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor
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Genomic Views
for RAET1G gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for RAET1G
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAET1G
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAET1G |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.1-q25.1 Ensembl cytogenetic band: 6q25.1 HGNC cytogenetic band: 6q24.1-25.1RAET1G Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M150238: view genomic region
(about GC identifiers)
Start:
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150,238,014 bp from pter |
End:
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150,244,257 bp from pter |
Size:
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6,244 bases |
Orientation:
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minus strand |
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Proteins
for RAET1G gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RET1G_HUMAN, Q6H3X3 (See
protein sequence)Recommended Name: Retinoic acid early transcript 1G protein precursor Size: 334 amino acids; 37106 Da
Subunit: Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16
Subcellular location: Cell membrane; Single-pass type I membrane protein
Secondary accessions: Q6H3X2Alternative splicing: 2 isoforms: Q6H3X3-1 Q6H3X3-2 Explore the universe of human proteins at neXtProt for RAET1G: NX_Q6H3X3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6H3X3
RAET1G Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001788.2
ENSEMBL proteins: ENSP00000356329 ENSP00000356330 ENSP00000417503
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
RAET1G for ontologies About GeneDecksing
RAET1G Antibody Products:
Assay Products for RAET1G: |
Protein
Domains /
Families
for RAET1G gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAET1G for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6H3X3ProtoNet protein and cluster: Q6H3X3 1 Blocks protein family: IPB001039 MHC class I signature
UniProtKB/Swiss-Prot: RET1G_HUMAN, Q6H3X3Similarity: Belongs to the MHC class I family |
Function
for RAET1G gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RET1G_HUMAN, Q6H3X3Function: Acts as a ligand for the NKG2D receptor and mediates NK cell cytotoxicity via the receptor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAET1G (NM_001001788) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAET1G | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1G |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RAET1G for ontologies About GeneDecksing
|
Pathways & Interactions
for RAET1G gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Natural killer cell mediated cytotoxicity | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for RAET1G):
RAET1G for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAET1G
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for RAET1G (Q6H3X33 ENSP000003563294) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006955 | immune response |
IEA | -- | | GO:0019882 | antigen processing and presentation |
IEA | -- |
RAET1G for ontologies About GeneDecksing
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Drugs & Compounds
for RAET1G gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAET1G
Search CenterWatch for drugs/clinical trials and news about RAET1G / RET1G
|
Transcripts
for RAET1G gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAET1G gene: NM_001001788.2 Unigene Cluster for RAET1G: Retinoic acid early transcript 1G Hs.558792 [show with all ESTs]Unigene Representative Sequence: AY1725793 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367360(uc010kii.1 uc003qnm.2) ENST00000367361 ENST00000479265
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAET1G (NM_001001788) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAET1G | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1G |
Additional cDNA sequence: AK310157.1 AY172579.1 BC096719.1 BC098152.1 3 DOTS entries: DT.102838746 DT.91805455 DT.121383078 8 AceView cDNA sequences: AY172580 AY172579 AA583860 BF513861 AW510737 CD698506 BE711112 BF836799
GeneLoc Exon Structure
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Expression
for RAET1G gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAET1G expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCACCC
About this image
See RAET1G Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.558792
UniProtKB/Swiss-Prot: RET1G_HUMAN, Q6H3X3Tissue specificity: Highly expressed in colon and in a number of tumor cell lines
SABiosciences Custom PCR Arrays for RAET1G
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAET1G
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat RAET1G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAET1G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAET1G |
Orthologs
for RAET1G gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for RAET1G (if available)
TreeFam Gene Tree for RAET1G (if available) |
Paralogs
for RAET1G gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAET1G gene
- ULBP12 ULBP32 RAET1E2 RAET1L2 ULBP22
12 SIMAP similar genes for RAET1G using alignment to 7 protein entries: RET1G_HUMAN (see all proteins):RAET1H RAET1L ULBP2 ULBP1 ULBP3 RAET-1E
RAET1E HLA-Cw HLA C* HLA-A*03 HLA-Cw*15P HLA-C
RAET1G for paralogs About GeneDecksing
|
Genomic Variants
for RAET1G gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAET1G (150238014 - 150244257 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAET1G: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAET1G |
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Disorders
/ Diseases
for RAET1G gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RAET1G for disorders About MalaCards
RAET1G for disorders About GeneDecksing
OMIM gene information: 609244
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: RAET1G (3 documents)
Export disorders for RAET1G gene to outside databases
|
Publications
for RAET1G gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAET1G gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with RAET1G) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PubMed id 15240696)1, 2, 3, 9 Bacon L.... Trowsdale J. (2004)
- A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PubMed id 11827464)1, 3 Radosavljevic M.... Bahram S. (2002)
- Differential NKG2D binding to highly related human NK G2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain. (PubMed id 19424970)1, 9 Wittenbrink M....Steinle A. (2009)
- Post-translational modification of the NKG2D ligand R AET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. (PubMed id 20304922)1, 9 Ohashi M....Trowsdale J. (2010)
- Polymorphisms of NKG2D ligands: diverse RAET1/ULBP ge nes in northeastern Thais. (PubMed id 19688209)1, 9 Romphruk A.V....Leelayuwat C. (2009)
- Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evi dence of diversity between human populations. (PubMed id 20219610)1, 9 Antoun A....Briggs D.C. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G. (PubMed id 19223974)1 Eagle R.A....Trowsdale J. (2009)
- Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for RAET1G gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing RAET1G gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAET1G gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAET1G gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for RAET1G | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for RAET1G gene:
Search GeneIP for patents involving RAET1G
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAET1G gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAET1G | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAET1G | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAET1G | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAET1G | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAET1G | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAET1G | | OriGene Custom Protein Services for RAET1G | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAET1G | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAET1G | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAET1G | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAET1G | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAET1G | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAET1G |
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| | | | Search Tocris compounds for RAET1G |
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 | | | RAET1G Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for RAET1G |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAET1G |
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