Aliases for RAET1G Gene
External Ids for RAET1G Gene
Previous GeneCards Identifiers for RAET1G Gene
This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
GeneCards Summary for RAET1G Gene
RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Natural Killer Cell Receptors: Human Target Cell -- NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.
UniProtKB/Swiss-Prot for RAET1G Gene
Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.