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Aliases for RAET1G Gene

Aliases for RAET1G Gene

  • Retinoic Acid Early Transcript 1G 2 3
  • UL-16 Binding Protein 5 3 4
  • ULBP5 3 4
  • Retinoic Acid Early Transcript 1G Pseudogene 2
  • Retinoic Acid Early Transcript 1G Protein 3

External Ids for RAET1G Gene

Summaries for RAET1G Gene

Entrez Gene Summary for RAET1G Gene

  • Members of the RAET1 family, such as RAET1G, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E (MIM 609243) and RAET1G differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RAET1G Gene

RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for RAET1G Gene

  • Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1G Gene

Genomics for RAET1G Gene

Genomic Location for RAET1G Gene

Start:
149,916,878 bp from pter
End:
149,923,133 bp from pter
Size:
6,256 bases
Orientation:
Minus strand

Genomic View for RAET1G Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAET1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1G Gene

No data available for Regulatory Elements for RAET1G Gene

Proteins for RAET1G Gene

  • Protein details for RAET1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H3X3-RET1G_HUMAN
    Recommended name:
    Retinoic acid early transcript 1G protein
    Protein Accession:
    Q6H3X3
    Secondary Accessions:
    • Q6H3X2

    Protein attributes for RAET1G Gene

    Size:
    334 amino acids
    Molecular mass:
    37106 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16.

    Alternative splice isoforms for RAET1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1G Gene

Proteomics data for RAET1G Gene at MOPED

Post-translational modifications for RAET1G Gene

  • The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.
  • Glycosylation at Asn82

Other Protein References for RAET1G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAET1G Gene

Domains for RAET1G Gene

Protein Domains for RAET1G Gene

UniProtKB/Swiss-Prot:

RET1G_HUMAN
Family:
  • Belongs to the MHC class I family.:
    • Q6H3X3
genes like me logo Genes that share domains with RAET1G: view

No data available for Gene Families for RAET1G Gene

Function for RAET1G Gene

Molecular function for RAET1G Gene

UniProtKB/Swiss-Prot Function: Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

Gene Ontology (GO) - Molecular Function for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1G: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for RAET1G Gene

Localization for RAET1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1G Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAET1G Gene COMPARTMENTS Subcellular localization image for RAET1G gene
Compartment Confidence
plasma membrane 5
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane NAS 15240696
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RAET1G: view

Pathways for RAET1G Gene

genes like me logo Genes that share pathways with RAET1G: view

Pathways by source for RAET1G Gene

1 KEGG pathway for RAET1G Gene

Interacting Proteins for RAET1G Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356329%0d%0a9606.ENSP00000240618%0d%0a9606.ENSP00000455951%0d%0a9606.ENSP00000229708%0d%0a
Selected Interacting proteins: ENSP00000356329 Q6H3X3-RET1G_HUMAN for RAET1G Gene via STRING I2D

Gene Ontology (GO) - Biological Process for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006955 immune response --
GO:0019882 antigen processing and presentation --
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
genes like me logo Genes that share ontologies with RAET1G: view

Transcripts for RAET1G Gene

mRNA/cDNA for RAET1G Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAET1G Gene

Retinoic acid early transcript 1G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1G Gene

No ASD Table

Relevant External Links for RAET1G Gene

GeneLoc Exon Structure for
RAET1G
ECgene alternative splicing isoforms for
RAET1G

Expression for RAET1G Gene

mRNA expression in normal human tissues for RAET1G Gene

mRNA differential expression in normal tissues according to GTEx for RAET1G Gene

This gene is overexpressed in Esophagus - Mucosa (10.9) and Adrenal Gland (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAET1G Gene

SOURCE GeneReport for Unigene cluster for RAET1G Gene Hs.558792

mRNA Expression by UniProt/SwissProt for RAET1G Gene

Q6H3X3-RET1G_HUMAN
Tissue specificity: Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.
genes like me logo Genes that share expressions with RAET1G: view

Orthologs for RAET1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 86 (a)
ManyToMany
-- 37
  • 84 (a)
ManyToMany
RAET1G 36
  • 97.21 (n)
  • 94.91 (a)
cow
(Bos Taurus)
Mammalia RAET1G 37
  • 33 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 33 (a)
OneToMany
Species with no ortholog for RAET1G:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1G Gene

ENSEMBL:
Gene Tree for RAET1G (if available)
TreeFam:
Gene Tree for RAET1G (if available)

Paralogs for RAET1G Gene

Paralogs for RAET1G Gene

genes like me logo Genes that share paralogs with RAET1G: view

Variants for RAET1G Gene

Sequence variations from dbSNP and Humsavar for RAET1G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs3922946 -- 149,924,781(+) CCTGC(A/G)GCCAT upstream-variant-2KB
rs3922947 -- 149,924,856(+) CAGAA(A/G)CCAGA upstream-variant-2KB
rs4869767 -- 149,923,974(+) TCAGA(A/G)GCTTC upstream-variant-2KB
rs4869768 -- 149,924,067(+) AAATT(A/G)TCTTA upstream-variant-2KB
rs4870116 -- 149,923,553(+) CCCAT(A/C)CCCGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for RAET1G Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv886765 CNV Gain 21882294
esv2732866 CNV Deletion 23290073

Relevant External Links for RAET1G Gene

HapMap Linkage Disequilibrium report
RAET1G

Disorders for RAET1G Gene

Relevant External Links for RAET1G

Genetic Association Database (GAD)
RAET1G
Human Genome Epidemiology (HuGE) Navigator
RAET1G
genes like me logo Genes that share disorders with RAET1G: view

No data available for UniProtKB/Swiss-Prot for RAET1G Gene

Publications for RAET1G Gene

  1. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L. … Trowsdale J. (J. Immunol. 2004) 2 3 4 23
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23 49
  3. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 23 49
  4. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. (PMID: 20304922) Ohashi M. … Trowsdale J. (J. Biol. Chem. 2010) 3 4 23
  5. A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3. (PMID: 11827464) Radosavljevic M. … Bahram S. (Genomics 2002) 2 3

Products for RAET1G Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RAET1G
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RAET1G
    • Block miRNA regulation of RAET1G using miScript Target Protectors

    Sources for RAET1G Gene

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