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Aliases for RAET1G Gene

Aliases for RAET1G Gene

  • Retinoic Acid Early Transcript 1G 2 3 5
  • UL-16 Binding Protein 5 3 4
  • ULBP5 3 4
  • Retinoic Acid Early Transcript 1G Pseudogene 2
  • Retinoic Acid Early Transcript 1G Protein 3

External Ids for RAET1G Gene

Previous GeneCards Identifiers for RAET1G Gene

  • GC06U900331
  • GC06M150323
  • GC06M150279
  • GC06M150238
  • GC06M147803

Summaries for RAET1G Gene

Entrez Gene Summary for RAET1G Gene

  • This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

GeneCards Summary for RAET1G Gene

RAET1G (Retinoic Acid Early Transcript 1G) is a Protein Coding gene. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Metabolism of proteins. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP2.

UniProtKB/Swiss-Prot for RAET1G Gene

  • Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

Additional gene information for RAET1G Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1G Gene

Genomics for RAET1G Gene

Regulatory Elements for RAET1G Gene

Enhancers for RAET1G Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H150250 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4 -331.3 -331257 7 PKNOX1 ATF1 ARNT FEZF1 ZNF2 TCF12 ZNF766 GATA2 KLF7 FOS NUP43 PPIL4 ENSG00000231760 KATNA1 LATS1 ENSG00000238594 PPP1R14C RAET1G ULBP2 RAET1L
GH06H149470 1.5 Ensembl ENCODE dbSUPER 4.8 +450.1 450072 4 HDGF PKNOX1 FOXA2 FEZF1 ZNF143 ATF7 KLF7 ZNF548 RUNX3 SP3 LATS1 PPIL4 NUP43 RPS18P9 KATNA1 ENSG00000233330 ENSG00000231760 GINM1 RAET1G ZC3H12D
GH06H150864 1.4 ENCODE dbSUPER 4.5 -943.3 -943309 4 HDGF MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000231883 ENSG00000219298 RPS12P11 ENSG00000235972 PHBP1 AKAP12 ENSG00000216906 RAET1G MTHFD1L ARL4AP5
GH06H150266 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.6 -347.2 -347218 8 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF416 FOS SP3 LATS1 NUP43 PPIL4 KATNA1 ENSG00000233330 ENSG00000231760 RNU4-7P ENSG00000238594 RPS18P9 PPP1R14C
GH06H149925 1.3 Ensembl ENCODE 0.7 -2.9 -2906 1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ATF7 SP3 SP5 ENSG00000231760 ENSG00000216906 RAET1E RAET1G LOC105378052
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAET1G on UCSC Golden Path with GeneCards custom track

Promoters for RAET1G Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000205093 152 801 ZNF76 SIN3A FEZF1 RAD21 GLIS2 ZNF350 RCOR1 SP3 SP5 NFYC

Genomic Location for RAET1G Gene

Chromosome:
6
Start:
149,916,878 bp from pter
End:
149,923,152 bp from pter
Size:
6,275 bases
Orientation:
Minus strand

Genomic View for RAET1G Gene

Genes around RAET1G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAET1G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAET1G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1G Gene

Proteins for RAET1G Gene

  • Protein details for RAET1G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6H3X3-RET1G_HUMAN
    Recommended name:
    Retinoic acid early transcript 1G protein
    Protein Accession:
    Q6H3X3
    Secondary Accessions:
    • Q6H3X2

    Protein attributes for RAET1G Gene

    Size:
    334 amino acids
    Molecular mass:
    37106 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16.

    Alternative splice isoforms for RAET1G Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1G Gene

Post-translational modifications for RAET1G Gene

  • The functional form is cleaved C-terminally of the GPI-anchor and yields a 28 kDa protein.
  • Glycosylation at isoforms=282
  • Modification sites at PhosphoSitePlus

Other Protein References for RAET1G Gene

No data available for DME Specific Peptides for RAET1G Gene

Domains & Families for RAET1G Gene

Gene Families for RAET1G Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RAET1G Gene

Graphical View of Domain Structure for InterPro Entry

Q6H3X3

UniProtKB/Swiss-Prot:

RET1G_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1G: view

Function for RAET1G Gene

Molecular function for RAET1G Gene

UniProtKB/Swiss-Prot Function:
Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

Gene Ontology (GO) - Molecular Function for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1G: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAET1G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAET1G Gene

Localization for RAET1G Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1G Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Mainly found inside the cell, with a minority of the protein reaching the cell surface.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAET1G gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS,NAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RAET1G: view

Pathways & Interactions for RAET1G Gene

genes like me logo Genes that share pathways with RAET1G: view

Interacting Proteins for RAET1G Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000356329%0d%0a9606.ENSP00000286380%0d%0a9606.ENSP00000349709%0d%0a9606.ENSP00000229708%0d%0a9606.ENSP00000240618%0d%0a
Selected Interacting proteins: Q6H3X3-RET1G_HUMAN ENSP00000356329 for RAET1G Gene via IID STRING

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
KLRK1

Gene Ontology (GO) - Biological Process for RAET1G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
genes like me logo Genes that share ontologies with RAET1G: view

No data available for SIGNOR curated interactions for RAET1G Gene

Drugs & Compounds for RAET1G Gene

No Compound Related Data Available

Transcripts for RAET1G Gene

mRNA/cDNA for RAET1G Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAET1G Gene

Retinoic acid early transcript 1G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAET1G
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1G Gene

No ASD Table

Relevant External Links for RAET1G Gene

GeneLoc Exon Structure for
RAET1G
ECgene alternative splicing isoforms for
RAET1G

Expression for RAET1G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAET1G Gene

mRNA differential expression in normal tissues according to GTEx for RAET1G Gene

This gene is overexpressed in Esophagus - Mucosa (x10.9) and Adrenal Gland (x9.5).

Protein differential expression in normal tissues from HIPED for RAET1G Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAET1G Gene



Protein tissue co-expression partners for RAET1G Gene

NURSA nuclear receptor signaling pathways regulating expression of RAET1G Gene:

RAET1G

SOURCE GeneReport for Unigene cluster for RAET1G Gene:

Hs.558792

mRNA Expression by UniProt/SwissProt for RAET1G Gene:

Q6H3X3-RET1G_HUMAN
Tissue specificity: Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.
genes like me logo Genes that share expression patterns with RAET1G: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAET1G Gene

Orthologs for RAET1G Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAET1G 33
  • 97.21 (n)
-- 34
  • 86 (a)
ManyToMany
-- 34
  • 84 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia RAET1G 34
  • 33 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 33 (a)
OneToMany
Species where no ortholog for RAET1G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1G Gene

ENSEMBL:
Gene Tree for RAET1G (if available)
TreeFam:
Gene Tree for RAET1G (if available)

Paralogs for RAET1G Gene

Paralogs for RAET1G Gene

genes like me logo Genes that share paralogs with RAET1G: view

Variants for RAET1G Gene

Sequence variations from dbSNP and Humsavar for RAET1G Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000039719 -- 149,927,962(+) TCATT(A/G)CGGTT upstream-variant-2KB
rs1000072376 -- 149,927,687(+) GAATA(A/G)TGCCA upstream-variant-2KB
rs1000219338 -- 149,924,088(+) TCTTG(C/T)TGGGA upstream-variant-2KB, utr-variant-5-prime
rs1000277273 -- 149,924,353(+) GCCTG(G/T)TCCCC upstream-variant-2KB, utr-variant-5-prime
rs1000287400 -- 149,918,792(+) GTTTC(A/G)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAET1G Gene

Variant ID Type Subtype PubMed ID
esv2732866 CNV deletion 23290073
esv3890963 CNV loss 25118596
nsv517022 CNV gain+loss 19592680
nsv970172 CNV duplication 23825009

Variation tolerance for RAET1G Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAET1G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAET1G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1G Gene

Disorders for RAET1G Gene

Relevant External Links for RAET1G

Genetic Association Database (GAD)
RAET1G
Human Genome Epidemiology (HuGE) Navigator
RAET1G
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAET1G

No disorders were found for RAET1G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAET1G Gene

Publications for RAET1G Gene

  1. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L … Trowsdale J (Journal of immunology (Baltimore, Md. : 1950) 2004) 2 3 4 22 60
  2. Post-translational modification of the NKG2D ligand RAET1G leads to cell surface expression of a glycosylphosphatidylinositol-linked isoform. (PMID: 20304922) Ohashi M … Trowsdale J (The Journal of biological chemistry 2010) 3 4 22 60
  3. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 22 45 60
  4. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 22 45 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for RAET1G Gene

Sources for RAET1G Gene

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