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Aliases for RAET1E Gene

Aliases for RAET1E Gene

  • Retinoic Acid Early Transcript 1E 2 3 4
  • Lymphocyte Effector Toxicity Activation Ligand 3 4
  • RAE-1-Like Transcript 4 3 4
  • NKG2DL4 3 4
  • N2DL-4 3 4
  • LETAL 3 4
  • ULBP4 3 4
  • RL-4 3 4
  • NKG2D Ligand 4 3
  • BA350J20.7 3
  • RAET1E2 3
  • N2DL4 4

External Ids for RAET1E Gene

Previous GeneCards Identifiers for RAET1E Gene

  • GC06M150164
  • GC06M150240
  • GC06M150297
  • GC06M150251
  • GC06M150209
  • GC06M147775

Summaries for RAET1E Gene

Entrez Gene Summary for RAET1E Gene

  • This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for RAET1E Gene

RAET1E (Retinoic Acid Early Transcript 1E) is a Protein Coding gene. Diseases associated with RAET1E include cerebral angioma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Immune response Role of DAP12 receptors in NK cells. GO annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for RAET1E Gene

  • Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes

Gene Wiki entry for RAET1E Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1E Gene

Genomics for RAET1E Gene

Regulatory Elements for RAET1E Gene

Genomic Location for RAET1E Gene

Start:
149,883,375 bp from pter
End:
149,898,102 bp from pter
Size:
14,728 bases
Orientation:
Minus strand

Genomic View for RAET1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAET1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1E Gene

Proteins for RAET1E Gene

  • Protein details for RAET1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD07-N2DL4_HUMAN
    Recommended name:
    NKG2D ligand 4
    Protein Accession:
    Q8TD07
    Secondary Accessions:
    • A6YF59
    • Q5VYB7
    • Q5VYB8
    • Q8TEZ2
    • Q96L41

    Protein attributes for RAET1E Gene

    Size:
    263 amino acids
    Molecular mass:
    30122 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D. Does not interacts with the CMV glycoprotein UL16.
    Miscellaneous:
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides

    Alternative splice isoforms for RAET1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1E Gene

Proteomics data for RAET1E Gene at MOPED

Post-translational modifications for RAET1E Gene

  • Glycosylation at Asn36, Asn154, and Asn212
  • Modification sites at PhosphoSitePlus

Other Protein References for RAET1E Gene

Antibody Products

  • R&D Systems Antibodies for RAET1E (ULBP-4/RAET1E)

No data available for DME Specific Peptides for RAET1E Gene

Domains for RAET1E Gene

Protein Domains for RAET1E Gene

Suggested Antigen Peptide Sequences for RAET1E Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD07

UniProtKB/Swiss-Prot:

N2DL4_HUMAN :
  • Q8TD07
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1E: view

No data available for Gene Families for RAET1E Gene

Function for RAET1E Gene

Molecular function for RAET1E Gene

UniProtKB/Swiss-Prot Function: Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes

Gene Ontology (GO) - Molecular Function for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042605 peptide antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1E: view

Animal Model Products

CRISPR Products

miRNA for RAET1E Gene

miRTarBase miRNAs that target RAET1E

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAET1E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAET1E Gene

Localization for RAET1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1E Gene

Membrane; Single-pass type I membrane protein.
Isoform RAET1E2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAET1E Gene COMPARTMENTS Subcellular localization image for RAET1E gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RAET1E: view

Pathways for RAET1E Gene

genes like me logo Genes that share pathways with RAET1E: view

Pathways by source for RAET1E Gene

Gene Ontology (GO) - Biological Process for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IBA --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IBA --
GO:0006955 immune response --
GO:0019882 antigen processing and presentation --
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
genes like me logo Genes that share ontologies with RAET1E: view

Compounds for RAET1E Gene

(1) Novoseek inferred chemical compound relationships for RAET1E Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 65.3 1
genes like me logo Genes that share compounds with RAET1E: view

Transcripts for RAET1E Gene

Unigene Clusters for RAET1E Gene

Retinoic acid early transcript 1E:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for RAET1E

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1E Gene

No ASD Table

Relevant External Links for RAET1E Gene

GeneLoc Exon Structure for
RAET1E
ECgene alternative splicing isoforms for
RAET1E

Expression for RAET1E Gene

mRNA expression in normal human tissues for RAET1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAET1E Gene

This gene is overexpressed in Esophagus - Mucosa (17.7), Vagina (8.6), Cervix - Ectocervix (6.6), Skin - Sun Exposed (Lower leg) (4.4), and Skin - Not Sun Exposed (Suprapubic) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RAET1E Gene

SOURCE GeneReport for Unigene cluster for RAET1E Gene Hs.511818

mRNA Expression by UniProt/SwissProt for RAET1E Gene

Q8TD07-N2DL4_HUMAN
Tissue specificity: Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.
genes like me logo Genes that share expressions with RAET1E: view

In Situ Assay Products

Orthologs for RAET1E Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIC 36
  • 95 (a)
OneToOne
RAET1E 35
  • 98.07 (n)
  • 96.14 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 49 (a)
OneToMany
-- 36
  • 43 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAET1E 36
  • 38 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Raet1e 16
Species with no ortholog for RAET1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1E Gene

ENSEMBL:
Gene Tree for RAET1E (if available)
TreeFam:
Gene Tree for RAET1E (if available)

Paralogs for RAET1E Gene

Paralogs for RAET1E Gene

Selected SIMAP similar genes for RAET1E Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAET1E: view

Variants for RAET1E Gene

Sequence variations from dbSNP and Humsavar for RAET1E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
VAR_020271 -
VAR_024534 -
VAR_024535 -
VAR_024536 -
VAR_050408 -

Structural Variations from Database of Genomic Variants (DGV) for RAET1E Gene

Variant ID Type Subtype PubMed ID
nsv886764 CNV Loss 21882294
nsv517022 CNV Gain+Loss 19592680
nsv886765 CNV Gain 21882294
nsv819758 CNV Loss 19587683

Relevant External Links for RAET1E Gene

HapMap Linkage Disequilibrium report
RAET1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1E Gene

Disorders for RAET1E Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for RAET1E Gene including...

Search for RAET1E Gene in MalaCards »

(1) University of Copenhagen DISEASES for RAET1E Gene

(1) Novoseek inferred disease relationships for RAET1E Gene

Disease -log(P) Hits PubMed IDs
tumors 1.51 5

Relevant External Links for RAET1E

Genetic Association Database (GAD)
RAET1E
Human Genome Epidemiology (HuGE) Navigator
RAET1E
genes like me logo Genes that share disorders with RAET1E: view

No data available for UniProtKB/Swiss-Prot for RAET1E Gene

Publications for RAET1E Gene

  1. ULBP4 is a novel ligand for human NKG2D. (PMID: 12732206) Chalupny N.J. … Cosman D. (Biochem. Biophys. Res. Commun. 2003) 3 4 23
  2. Letal, a tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. (PMID: 14508119) Conejo-Garcia J.-R. … Coukos G. (Cancer Biol. Ther. 2003) 3 4 23
  3. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L. … Trowsdale J. (J. Immunol. 2004) 3 4 23
  4. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. (PMID: 17470428) Cao W. … He W. (J. Biol. Chem. 2007) 3 4 23
  5. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 23 48

Products for RAET1E Gene

Sources for RAET1E Gene

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