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Aliases for RAET1E Gene

Aliases for RAET1E Gene

  • Retinoic Acid Early Transcript 1E 2 3 4 5
  • Lymphocyte Effector Toxicity Activation Ligand 3 4
  • RAE-1-Like Transcript 4 3 4
  • NKG2DL4 3 4
  • N2DL-4 3 4
  • LETAL 3 4
  • ULBP4 3 4
  • RL-4 3 4
  • NKG2D Ligand 4 3
  • BA350J20.7 3
  • RAET1E2 3
  • N2DL4 4

External Ids for RAET1E Gene

Previous GeneCards Identifiers for RAET1E Gene

  • GC06M150164
  • GC06M150240
  • GC06M150297
  • GC06M150251
  • GC06M150209
  • GC06M147775

Summaries for RAET1E Gene

Entrez Gene Summary for RAET1E Gene

  • This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for RAET1E Gene

RAET1E (Retinoic Acid Early Transcript 1E) is a Protein Coding gene. Diseases associated with RAET1E include Basidiobolomycosis and Intracranial Structure Hemangioma. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions. GO annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ULBP3.

UniProtKB/Swiss-Prot for RAET1E Gene

  • Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.

Gene Wiki entry for RAET1E Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAET1E Gene

Genomics for RAET1E Gene

Regulatory Elements for RAET1E Gene

Enhancers for RAET1E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G149886 1.4 Ensembl ENCODE dbSUPER 22.9 +9.1 9116 5.2 FOS TSHZ1 MEF2D PBX2 STAT3 WT1 SP7 LEF1 GTF2E2 ZNF175 ENSG00000216906 RAET1E ENSG00000231760 LRP11 LOC105378051
GH06G149842 1.6 Ensembl ENCODE dbSUPER 18 +53.1 53106 6.4 HDGF FOXA2 PKNOX1 ARNT SIN3A ZNF207 FOS ZNF263 MCM3 JUNB ENSG00000231760 LATS1 RPS18P9 RAET1E GINM1 ENSG00000233330 ENSG00000202343 LRP11 ENSG00000273132
GH06G149858 1.6 Ensembl ENCODE dbSUPER 15.9 +36.2 36219 6.4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ENSG00000216906 ENSG00000231760 RAET1E LATS1 NUP43 LRP11 ULBP1 ENSG00000268592 ENSG00000273132
GH06G149894 1.3 Ensembl ENCODE dbSUPER 17.2 +1.7 1706 3.6 ELF3 TBP FOXA2 ZSCAN4 RAD21 ZEB1 GTF3C2 RCOR1 ZNF548 FOS NUP43 LATS1 ENSG00000216906 KATNA1 RAET1E PPIL4 ENSG00000231760 LRP11 LOC105378051
GH06G149840 1.4 Ensembl ENCODE dbSUPER 12.3 +57.5 57470 1.5 ELF3 RB1 ARID4B SIN3A ZNF48 RAD21 SLC30A9 ZSCAN5C SCRT2 ZNF143 ENSG00000231760 LRP11 RAET1E GINM1 ENSG00000202343 ENSG00000233330 RPS18P9 ENSG00000273132
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAET1E on UCSC Golden Path with GeneCards custom track

Genomic Location for RAET1E Gene

Chromosome:
6
Start:
149,864,397 bp from pter
End:
149,898,321 bp from pter
Size:
33,925 bases
Orientation:
Minus strand

Genomic View for RAET1E Gene

Genes around RAET1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAET1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAET1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1E Gene

Proteins for RAET1E Gene

  • Protein details for RAET1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD07-N2DL4_HUMAN
    Recommended name:
    NKG2D ligand 4
    Protein Accession:
    Q8TD07
    Secondary Accessions:
    • A6YF59
    • Q5VYB7
    • Q5VYB8
    • Q8TEZ2
    • Q96L41

    Protein attributes for RAET1E Gene

    Size:
    263 amino acids
    Molecular mass:
    30122 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D. Does not interacts with the CMV glycoprotein UL16.
    Miscellaneous:
    • The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.

    Alternative splice isoforms for RAET1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAET1E Gene

Post-translational modifications for RAET1E Gene

  • Glycosylation at Asn36, isoforms=2, 3, 4154, and isoforms=2212
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for RAET1E (ULBP-4/RAET1E)

No data available for DME Specific Peptides for RAET1E Gene

Domains & Families for RAET1E Gene

Protein Domains for RAET1E Gene

Suggested Antigen Peptide Sequences for RAET1E Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD07

UniProtKB/Swiss-Prot:

N2DL4_HUMAN :
  • Belongs to the MHC class I family.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1E: view

No data available for Gene Families for RAET1E Gene

Function for RAET1E Gene

Molecular function for RAET1E Gene

UniProtKB/Swiss-Prot Function:
Ligand for the KLRK1 receptor. Delivers activating signals to NK cells and promotes tumor immune surveillance by inducing the expansion of anti-tumor cytotoxic lymphocytes.

Gene Ontology (GO) - Molecular Function for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003823 antigen binding IBA --
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1E: view

Phenotypes for RAET1E Gene

GenomeRNAi human phenotypes for RAET1E:
genes like me logo Genes that share phenotypes with RAET1E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAET1E Gene

Localization for RAET1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1E Gene

Membrane; Single-pass type I membrane protein.
Isoform RAET1E2: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAET1E gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RAET1E: view

Pathways & Interactions for RAET1E Gene

genes like me logo Genes that share pathways with RAET1E: view

Interacting Proteins for RAET1E Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000349709%0d%0a9606.ENSP00000246551%0d%0a9606.ENSP00000356329%0d%0a9606.ENSP00000286380%0d%0a9606.ENSP00000240618%0d%0a
Selected Interacting proteins: Q8TD07-N2DL4_HUMAN ENSP00000349709 for RAET1E Gene via IID STRING

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
HLA-DRB1
HCST

Gene Ontology (GO) - Biological Process for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IBA --
GO:0019882 antigen processing and presentation IBA --
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with RAET1E: view

No data available for SIGNOR curated interactions for RAET1E Gene

Drugs & Compounds for RAET1E Gene

(1) Additional Compounds for RAET1E Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAET1E: view

Transcripts for RAET1E Gene

mRNA/cDNA for RAET1E Gene

Unigene Clusters for RAET1E Gene

Retinoic acid early transcript 1E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1E Gene

No ASD Table

Relevant External Links for RAET1E Gene

GeneLoc Exon Structure for
RAET1E
ECgene alternative splicing isoforms for
RAET1E

Expression for RAET1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAET1E Gene

mRNA differential expression in normal tissues according to GTEx for RAET1E Gene

This gene is overexpressed in Esophagus - Mucosa (x17.7), Vagina (x8.6), Cervix - Ectocervix (x6.6), Skin - Sun Exposed (Lower leg) (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAET1E Gene



NURSA nuclear receptor signaling pathways regulating expression of RAET1E Gene:

RAET1E

SOURCE GeneReport for Unigene cluster for RAET1E Gene:

Hs.511818

mRNA Expression by UniProt/SwissProt for RAET1E Gene:

Q8TD07-N2DL4_HUMAN
Tissue specificity: Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.
genes like me logo Genes that share expression patterns with RAET1E: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAET1E Gene

Orthologs for RAET1E Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAET1E 34
  • 98.07 (n)
MIC 35
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 49 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAET1E 35
  • 38 (a)
OneToOne
Species where no ortholog for RAET1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAET1E Gene

ENSEMBL:
Gene Tree for RAET1E (if available)
TreeFam:
Gene Tree for RAET1E (if available)

Paralogs for RAET1E Gene

Paralogs for RAET1E Gene

(7) SIMAP similar genes for RAET1E Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAET1E: view

Variants for RAET1E Gene

Sequence variations from dbSNP and Humsavar for RAET1E Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000129010 -- 149,885,163(+) TTGTG(G/T)CTTGC intron-variant
rs1000248833 -- 149,881,983(+) GACGT(A/G)GAATC intron-variant
rs1000301076 -- 149,881,579(+) AGGCA(C/G)CCCGC intron-variant
rs1000381305 -- 149,892,932(+) TAGCC(A/G)GTTTT intron-variant, upstream-variant-2KB
rs1000465444 -- 149,887,659(+) TTTCT(A/C)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAET1E Gene

Variant ID Type Subtype PubMed ID
esv3890963 CNV loss 25118596
nsv517022 CNV gain+loss 19592680
nsv819758 CNV loss 19587683

Variation tolerance for RAET1E Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAET1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAET1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1E Gene

Disorders for RAET1E Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAET1E Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
basidiobolomycosis
  • infection by basidiobolus
intracranial structure hemangioma
  • angioma of intracranial structure
brain angioma
  • brain hemangioma
cerebral angioma
  • hemangioma of cerebrum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAET1E

Genetic Association Database (GAD)
RAET1E
Human Genome Epidemiology (HuGE) Navigator
RAET1E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAET1E
genes like me logo Genes that share disorders with RAET1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAET1E Gene

Publications for RAET1E Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A. … Briggs D.C. (Hum. Immunol. 2010) 3 22 46 64
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk A.V. … Leelayuwat C. (Immunogenetics 2009) 3 22 46 64
  3. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. (PMID: 17470428) Cao W. … He W. (J. Biol. Chem. 2007) 3 4 22 64
  4. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L. … Trowsdale J. (J. Immunol. 2004) 3 4 22 64
  5. ULBP4 is a novel ligand for human NKG2D. (PMID: 12732206) Chalupny N.J. … Cosman D. (Biochem. Biophys. Res. Commun. 2003) 3 4 22 64

Products for RAET1E Gene

Sources for RAET1E Gene

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