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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAE1 Gene

protein-coding   GIFtS: 61
GCID: GC20P055926

Ribonucleic Acid Export 1

(Previous names: RAE1 (RNA export 1, S.pombe) homolog, RAE1 RNA export 1...)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ribonucleic Acid Export 11 2     dJ481F12.32
MRNA-Associated Protein Mrnp 412 3     dJ800J21.12
Rae1 Protein Homolog2 3     Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa
(Kraemer)2
MRNP412 3     Migration-Inducing Gene 142
RAE1 (RNA Export 1, S.Pombe) Homolog1     MRNA Export Factor2
RAE1 RNA Export 1 Homolog (S. Pombe)1     MRNA Export Protein2
MIG142     MRNA-Binding Protein, 41-KD2
Mnrp412     RAE1 RNA Export 1 Homolog2

External Ids:    HGNC: 98281   Entrez Gene: 84802   Ensembl: ENSG000001011467   OMIM: 6033435   UniProtKB: P784063   

Export aliases for RAE1 gene to outside databases

Previous GC identifers: GC20P055654 GC20P056564 GC20P056611 GC20P055359 GC20P052708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAE1 Gene:
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result
in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in
RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has
been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures
throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or
indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAE1 Gene: 
RAE1 (ribonucleic acid export 1) is a protein-coding gene. Diseases associated with RAE1 include influenza, and ischemia, and among its related super-pathways are Interactions of Rev with host cellular proteins and HIV Life Cycle. GO annotations related to this gene include microtubule binding and RNA binding. An important paralog of this gene is BUB3.

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406
Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching
cytoplasmic mRNPs to the cytoskeleton

Gene Wiki entry for RAE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAE1 gene promoter:
         CBF-A   CBF-B   POU2F1   POU2F1a   IRF-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAE1 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAE1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

RAE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAE1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055926:  view genomic region     (about GC identifiers)

Start:
55,926,066 bp from pter      End:
55,954,267 bp from pter
Size:
28,202 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406 (See protein sequence)
Recommended Name: mRNA export factor  
Size: 368 amino acids; 40968 Da
Subunit: Interacts with NUP98
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for RAE1:
3MMY (3D)    
Secondary accessions: A8K882 O15306 Q3SYL7 Q5TCH8 Q6V708 Q9H100 Q9NQM6

Explore the universe of human proteins at neXtProt for RAE1: NX_P78406

Explore proteomics data for RAE1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P78406

  • RAE1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAE1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001015885.1  NP_003601.1  

    ENSEMBL proteins: 
     ENSP00000379182   ENSP00000360286   ENSP00000432609   ENSP00000432698   ENSP00000392097  
     ENSP00000393264   ENSP00000379181   ENSP00000402924  
    Reactome Protein details: P78406
    Human Recombinant Protein Products for RAE1: 
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    Cloud-Clone Corp. Proteins for RAE1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS9370289
    GO:0005635nuclear envelope TAS--
    GO:0005640nuclear outer membrane TAS9256445
    GO:0005643nuclear pore TAS10209021
    GO:0005737cytoplasm IEA--

    RAE1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P78406

    ProtoNet protein and cluster: P78406

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406
    Similarity: Belongs to the WD repeat rae1 family
    Similarity: Contains 7 WD repeats


    RAE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAE1L_HUMAN, P78406
    Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching
    cytoplasmic mRNPs to the cytoskeleton

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9256445
    GO:0005515protein binding ----
    GO:0008017microtubule binding ISS15851029
         
    RAE1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAE1:
     Increased HPV18 LCR reporter a  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rae1):
     adipose tissue  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     integument  mortality/aging  muscle  skeleton  tumorigenesis 
     vision/eye 

    RAE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rae1tm1Jvd for RAE1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAE1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAE1 
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    SwitchGear 3'UTR luciferase reporter plasmidRAE1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAE1 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Rev-mediated nuclear export of HIV RNA0.94
    Hexose transport0.87
    Nuclear import of Rev protein0.94
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.82
    Interactions of Rev with host cellular proteins0.94
    Nuclear Pore Complex (NPC) Disassembly0.77
    Vpr-mediated nuclear import of PICs0.91
    Nuclear Envelope Breakdown0.77
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    4M Phase
    M Phase0.88
    Mitotic M-M/G1 phases0.88
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/29        Reactome Pathways for RAE1 (see all 29)
        Antiviral mechanism by IFN-stimulated genes
    Late Phase of HIV Life Cycle
    Metabolism
    Cell Cycle
    M Phase


    2         Kegg Pathways  (Kegg details for RAE1):
        RNA transport
    Influenza A


    RAE1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/728 Interacting proteins for RAE1 (P784062, 3 ENSP000003602864) via UniProtKB, MINT, STRING, and/or I2D (see all 728)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-14382 MINT-14383 I2D: score=3 STRING: ENSP00000294172
    BUB1O436832, 3, ENSP000003025304MINT-7945693 I2D: score=3 STRING: ENSP00000302530
    NUP98P529482, 3, ENSP000003160324MINT-7294477 I2D: score=3 STRING: ENSP00000316032
    NUP155O756942, 3, ENSP000002314984MINT-7945693 I2D: score=2 STRING: ENSP00000231498
    COPS6Q7L5N12, 3, ENSP000003041024MINT-7945693 I2D: score=1 STRING: ENSP00000304102
    About this table

    Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006406mRNA export from nucleus TAS10209021
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    RAE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAE1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAE1 (RAE1L)

    1 Novoseek inferred chemical compound relationship for RAE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 35.6 4 11562472 (2), 12594837 (1), 11825567 (1)

    Search CenterWatch for drugs/clinical trials and news about RAE1 / RAE1L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAE1 gene (2 alternative transcripts): 
    NM_001015885.1  NM_003610.3  

    Unigene Cluster for RAE1:

    RAE1 RNA export 1 homolog (S. pombe)
    Hs.371698  [show with all ESTs]
    Unigene Representative Sequence: AY349350
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395841(uc002xyg.3) ENST00000371242 ENST00000527947(uc010gis.1 uc010git.1)
    ENST00000492498 ENST00000411894 ENST00000429339 ENST00000395840(uc002xyi.3)
    ENST00000452119 ENST00000462438
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK292247.1 AK307966.1 AK309069.1 AK309743.1 AY336091.1 AY349350.1 BC103754.1 BC106923.1 
    BC106924.1 U84720.1 

    24 DOTS entries:

    DT.318678  DT.95146479  DT.92448671  DT.100822112  DT.100822113  DT.120808322  DT.100822110  DT.452002 
    DT.97862107  DT.120808295  DT.120808344  DT.120808294  DT.92448673  DT.120808334  DT.91943371  DT.40116088 
    DT.75150463  DT.99999666  DT.100680340  DT.100724008  DT.95076500  DT.95313183  DT.95340794  DT.97862108 

    24/448 AceView cDNA sequences (see all 448):

    BQ064088 BF768823 CB119780 BM721346 BU740423 BQ001869 BU192149 T33529 
    AU134451 Z38772 F02097 BU615585 BP371333 BQ069752 AI373596 AW590594 
    AW402277 BI766896 F05854 BM803581 BU174010 CR601825 BU184960 BE410549 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                      -     -     -     -                                                                             -     -               
    SP2:                                                  -     -                                                                             -     -               
    SP3:                                      -     -     -     -                                                                             -     -     -         
    SP4:                                      -     -     -     -                 -                                                                                 
    SP5:                                -     -     -     -     -                                                                                                   

    ExUns: 14a · 14b ^ 15a · 15b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RAE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCAACC
    RAE1 Expression
    About this image


    See RAE1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAE1

    SOURCE GeneReport for Unigene cluster: Hs.371698
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAE1 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rae11 , 5 RAE1 RNA export 1 homolog (S. pombe)1, 5 88.68(n)1
    98.64(a)1
      2 (95.66 cM)5
    666791  NM_175112.51  NP_780321.11 
     1730001175 
    chicken
    (Gallus gallus)
    Aves RAE16
    Uncharacterized protein
    81(a)
    1 ↔ 1
    20(11977840-11991086)
    lizard
    (Anolis carolinensis)
    Reptilia RAE16
    Uncharacterized protein
    94(a)
    1 ↔ 1
    GL343217.1(1189864-1210621)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242742 Xenopus laevis Rae1/Gle2 (Rae1/Gle2) mRNA, complete more 79.75(n)    AY256464.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564492 similar to RAE1 RNA export 1 homolog (S. pombe) 78.45(n)   393973  BC049445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98623
    Rae11
    CG9862-PA1 68(a)
    (best of 2)3
    62.89(n)1
    69.77(a)1
      57F63
    374671  NM_137753.21  NP_611597.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rae-11 Protein RAE-1 51.38(n)
    51.93(a)
      172864  NM_060249.2  NP_492650.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLE2(YER107C)4
    GLE21
    Component of the Nup82 subcomplex of the nuclear pore more4
    Gle2p1
    51.13(n)1
    44.07(a)1
      5(374545-373448)4
    8568441, 4  NP_011033.31  NP_011033.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G806701 Rae1-like protein 56.7(n)
    54.68(a)
      844406  NM_106715.4  NP_178182.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01768001 hypothetical protein 57.13(n)
    54.72(a)
      4344798  NM_001067654.1  NP_001061119.1 


    ENSEMBL Gene Tree for RAE1 (if available)
    TreeFam Gene Tree for RAE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAE1 gene
    BUB32  
    1 SIMAP similar gene for RAE1 using alignment to 6 protein entries:     RAE1L_HUMAN (see all proteins):
    BUB3

    RAE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/682 SNPs in RAE1 are shown (see all 682)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137370691,2
    C--55924153(+) TATCTG/AGCTAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1483651231,2
    --55924169(+) TGGGGC/TCTTGG 1 -- us2k10--------
    rs1415820801,2
    --55924179(+) GAGAAC/TCTTTG 1 -- us2k10--------
    rs1867190591,2
    --55924264(+) GGATGC/TGGGTG 1 -- us2k10--------
    rs1504945761,2
    --55924267(+) TGTGGA/GTGGGG 1 -- us2k10--------
    rs1911792351,2
    --55924324(+) CTGCTC/GGGGGC 1 -- us2k10--------
    rs1839971711,2
    C--55924325(+) TGCTCA/GGGGCA 1 -- us2k10--------
    rs1180536261,2
    F--55924327(+) CTCGGG/CGCACC 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1868619071,2
    --55924329(+) CGGGGC/TACCTT 1 -- us2k10--------
    rs61236921,2
    F,A--55924332(+) ggcacC/Tttcca 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAE1 (55926066 - 55954267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAE1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3424CNV Insertion18451855
    nsv459027CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603343    OMIM disorders: --

    5 diseases for RAE1:    About MalaCards
    influenza    ischemia    neuroblastoma    hepatitis
    neuronitis


    RAE1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RAE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 7 11562472 (4)

    Human Genome Epidemiology (HuGE) Navigator: RAE1 (1 document)

    Export disorders for RAE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAE1 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with RAE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. (PubMed id 9370289)1, 2, 3, 9 Bharathi A....Dhar R. (1997)
    2. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. (PubMed id 9256445)1, 2, 3 Kraemer D.M. and Blobel G. (1997)
    3. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PubMed id 20498086)1, 2 Ren Y....Hoelz A. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    7. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. (PubMed id 11352911)1, 9 Wang X....van Deursen J.M. (2001)
    8. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. (PubMed id 8982867)1, 9 Nomura M....Shimada K. (1996)
    9. 14-3-3 proteins sequester a pool of soluble TRIM32 ubi quitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (2013)
    10. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8480 HGNC: 9828 AceView: RAE1 Ensembl:ENSG00000101146 euGenes: HUgn8480
    ECgene: RAE1 Kegg: 8480 H-InvDB: RAE1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAE1 gene:
    Search GeneIP for patents involving RAE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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