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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAE1 Gene

protein-coding GIFtS: 62
GCID: GC20P055926

RAE1 RNA export 1 homolog (S. pombe)

(Previous names: RAE1 (RNA export 1, S.pombe) homolog )

Explore 5 diseases affiliated with
RAE1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
RAE1 RNA Export 1 Homolog (S. Pombe)¹ ²		DJ481F12.3¹
Mnrp41¹ ²		DJ800J21.1¹
MRNA-Associated Protein Mrnp 41² ³		Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa (Kraemer)²
Rae1 Protein Homolog² ³		Migration-Inducing Gene 14²
MRNP41² ³		MRNA Export Factor²
RAE1 (RNA Export 1, S.Pombe) Homolog¹		MRNA Export Protein²
MIG14²		MRNA-Binding Protein, 41-KD²

External Ids:	HGNC: 9828¹	Entrez Gene: 8480²	Ensembl: ENSG00000101146⁷	OMIM: 603343⁵	UniProtKB: P78406³

Export aliases for RAE1 gene to outside databases

Previous GC identifers: GC20P055654 GC20P056564 GC20P056611 GC20P055359 GC20P052708

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAE1:

Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in

accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA

export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown

to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the

cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching

cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been

found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406

Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic

mRNPs to the cytoskeleton

Gene Wiki entry for RAE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011362.10

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAE1 gene promoter:
CBF-A CBF-B POU2F1 POU2F1a IRF-1 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAE1 promoter sequence

Search SABiosciences Chromatin IP Primers for RAE1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAE1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31 Ensembl cytogenetic band: 20q13.31 HGNC cytogenetic band: 20q13.31

RAE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAE1 gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P055926: view genomic region (about GC identifiers)

Start:	55,926,066 bp from pter	End:	55,954,267 bp from pter
Size:	28,202 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406 (See protein sequence)

Recommended Name: mRNA export factor

Size: 368 amino acids; 40968 Da

Subunit: Interacts with NUP98

Subcellular location: Cytoplasm. Nucleus

1 PDB 3D structure from and Proteopedia for RAE1:

3MMY (3D)

Secondary accessions: A8K882 O15306 Q3SYL7 Q5TCH8 Q6V708 Q9H100 Q9NQM6

Explore the universe of human proteins at neXtProt for RAE1: NX_P78406

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P78406

RAE1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001015885.1 NP_003601.1

ENSEMBL proteins:

ENSP00000379182 ENSP00000360286 ENSP00000432609 ENSP00000432698 ENSP00000392097

ENSP00000393264 ENSP00000379181 ENSP00000402924

Reactome Protein details: P78406
Human Recombinant Protein Products:

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	Novus Biologicals RAE1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for RAE1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9370289
GO:0005635	nuclear envelope	TAS	--
GO:0005640	nuclear outer membrane	TAS	9256445
GO:0005643	nuclear pore	TAS	9256445
GO:0005737	cytoplasm	IEA	--

RAE1 for ontologies About GeneDecksing

RAE1 Antibody Products:

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	Novus Biologicals RAE1 Antibodies
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	GenScript Custom Assay Services for RAE1
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	Uscn ELISAs and CLIAs for RAE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

RAE1 for domains About GeneDecksing

5 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR020472 G-protein_beta_WD-40_rep

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry P78406

ProtoNet protein and cluster: P78406

1 Blocks protein family: IPB001680 G-protein beta WD-40 repeat signature

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406

Similarity: Belongs to the WD repeat rae1 family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406

Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic

mRNPs to the cytoskeleton

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RAE1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAE1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RAE1 (see all 13):
		hsa-miR-34b* hsa-miR-34c-5p hsa-miR-3673 hsa-miR-520d-5p hsa-miR-449b hsa-miR-449a hsa-miR-519e* hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RAE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAE1 (see all 7) OriGene shRNA RFP: RAE1 OriGene siRNA: RAE1
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RAE1

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAE1
		Search LifeMap BioReagents cell lines for RAE1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAE1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003723	RNA binding	TAS	9256445
GO:0008017	microtubule binding	ISS	15851029

RAE1 for ontologies About GeneDecksing

4 GenomeRNAi human phenotypes for RAE1:

Increased HPV18 LCR reporter a

Nuclear 40S maturation defects

Nuclear 60S biogenesis defects

Nucleolar pre-40S maturation d

Animal Models:
Mouse knock-out Rae1^tm1Jvd for RAE1
11 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rae1):

adipose tissue	cellular	embryogenesis	growth/size	homeostasis/metabolism
integument	mortality/aging	muscle	skeleton	tumorigenesis
vision/eye

RAE1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus

8/11 pathways (see all 11)
Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus	1.00	Interactions of Vpr with host cellular proteins	0.70
Nuclear import of Rev protein	0.76	Glucose transport	0.57
Vpr-mediated nuclear import of PICs	0.76	Hexose transport	0.55
Regulation of Glucokinase by Glucokinase Regulatory Protein	0.75	ISG15 antiviral mechanism	0.49

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

HIV Infection

HIV Infection

1.00

Host Interactions of HIV factors

0.64

SLC-mediated transmembrane transport

SLC-mediated transmembrane transport

1.00

Transmembrane transport of small molecules

0.50

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Pathway sources
See GeneCards unified pathways
Show all pathways

5/23 Reactome Pathways for RAE1 (see all 23)

	Antiviral mechanism by IFN-stimulated genes
	Late Phase of HIV Life Cycle
	Metabolism
	Interactions of Rev with host cellular proteins
	Disease

2 Kegg Pathways (Kegg details for RAE1):

	RNA transport
	Influenza A

RAE1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAE1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/700 Interacting proteins for RAE1 (P78406^{2, 3} ENSP00000360286⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 700)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NXF1	Q9UBU9²^,³, ENSP00000294172⁴	MINT-14382 MINT-14383 I2D: score=3 STRING: ENSP00000294172
BUB1	O43683²^,³, ENSP00000302530⁴	MINT-7945693 I2D: score=3 STRING: ENSP00000302530
NUP98	P52948²^,³, ENSP00000316032⁴	MINT-7294477 I2D: score=3 STRING: ENSP00000316032
NUP155	O75694²^,³, ENSP00000231498⁴	MINT-7945693 I2D: score=2 STRING: ENSP00000231498
COPS6	Q7L5N1²^,³, ENSP00000304102⁴	MINT-7945693 I2D: score=1 STRING: ENSP00000304102

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006406	mRNA export from nucleus	TAS	10209021
GO:0008645	hexose transport	TAS	--
GO:0010827	regulation of glucose transport	TAS	--
GO:0015758	glucose transport	TAS	--

RAE1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

RAE1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAE1
1 Novoseek chemical compound relationship for RAE1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoic acid	35.6	4	11562472 (2), 12594837 (1), 11825567 (1)

Search CenterWatch for drugs/clinical trials and news about RAE1 / RAE1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAE1 gene (2 alternative transcripts):

NM_001015885.1 NM_003610.3

Unigene Cluster for RAE1:

RAE1 RNA export 1 homolog (S. pombe)

Hs.371698 [show with all ESTs]

Unigene Representative Sequence: AY349350

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395841(uc002xyg.3) ENST00000371242 ENST00000527947(uc010gis.1 uc010git.1)

ENST00000492498 ENST00000411894 ENST00000429339 ENST00000395840(uc002xyi.3)

ENST00000452119 ENST00000462438

miRNA Products:		OriGene 3'-UTR Clone (see all 2): RAE1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAE1
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RAE1 (see all 13):
		hsa-miR-34b* hsa-miR-34c-5p hsa-miR-3673 hsa-miR-520d-5p hsa-miR-449b hsa-miR-449a hsa-miR-519e* hsa-miR-515-5p

		SwitchGear 3'UTR luciferase reporter plasmid: RAE1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAE1 (see all 7) OriGene shRNA RFP: RAE1 OriGene siRNA: RAE1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAE1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAE1 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAE1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): RAE1 (NM_003610)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAE1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAE1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAE1

Additional cDNA sequence:

AK292247.1 AK307966.1 AK309069.1 AK309743.1 AY336091.1 AY349350.1 BC103754.1 BC106923.1

BC106924.1 U84720.1

24 DOTS entries:

DT.318678 DT.95146479 DT.92448671 DT.100822112 DT.100822113 DT.120808322 DT.100822110 DT.452002

DT.97862107 DT.120808295 DT.120808344 DT.120808294 DT.92448673 DT.120808334 DT.91943371 DT.40116088

DT.75150463 DT.99999666 DT.100680340 DT.100724008 DT.95076500 DT.95313183 DT.95340794 DT.97862108

24/448 AceView cDNA sequences (see all 448):

BQ439680 CR601825 BG281059 AW590594 BU186691 BQ650268 BF223716 BM907477

AL524723 F02097 T33529 BI828740 Z38772 BP371333 BU615585 AI362959

BF768823 CB112815 BM545685 AK126024 BG683045 BM721346 BM793921 AI433138

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8a	·	8b	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13	^
SP1:													-		-		-		-																										-		-
SP2:																	-		-																										-		-
SP3:													-		-		-		-																										-		-		-
SP4:													-		-		-		-						-
SP5:											-		-		-		-		-

ExUns:	14a	·	14b	^	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for RAE1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAE1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTTCAACC

About this image

RAE1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Glomerulus

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See RAE1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAE1

SOURCE GeneReport for Unigene cluster: Hs.371698

SABiosciences Custom PCR Arrays for RAE1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAE1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAE1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAE1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAE1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAE1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAE1 gene from 9/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	RAE1⁶	Uncharacterized protein	95(a)	1 ↔ 1	20(11598635-11605496)
lizard (Anolis carolinensis)	Reptilia	RAE1⁶	--	95(a)	1 ↔ 1	GL343217.1(1192707-1206222)
African clawed frog (Xenopus laevis)	Amphibia	Xl.24274²	Xenopus laevis Rae1/Gle2 (Rae1/Gle2) mRNA, complete more	79.75(n)		AY256464.1
zebrafish (Danio rerio)	Actinopterygii	zgc56449²	similar to RAE1 RNA export 1 homolog (S. pombe)	78.45(n)		393973 BC049445.1
fruit fly (Drosophila melanogaster)	Insecta	CG9862³ Rae1¹	CG9862-PA¹	68(a) (best of 2)³ 62.89(n)¹ 69.77(a)¹		57F6³ 37467¹ NM_137753.2¹ NP_611597.1¹
worm (Caenorhabditis elegans)	Secernentea	rae-1¹	Protein RAE-1	51.38(n) 51.93(a)		172864 NM_060249.2 NP_492650.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	GLE2(YER107C)⁴ GLE2¹	Component of the Nup82 subcomplex of the nuclear pore more⁴ Gle2p¹	51.13(n)¹ 44.07(a)¹		5(374545-373448)⁴ 856844^{1, 4} NP_011033.3¹ NP_011033.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G80670¹	Rae1-like protein	56.7(n) 54.68(a)		844406 NM_106715.4 NP_178182.1
rice (Oryza sativa)	Liliopsida	Os08g0176800¹	hypothetical protein	57.13(n) 54.72(a)		4344798 NM_001067654.1 NP_001061119.1

ENSEMBL Gene Tree for RAE1 (if available)
TreeFam Gene Tree for RAE1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAE1 gene

BUB3²

1 SIMAP similar gene for RAE1 using alignment to 6 protein entries: RAE1L_HUMAN (see all proteins):

BUB3

RAE1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113737069^1,2	C	--	55924153(+)	`TATCTG/AGCTAC`	1	--	us2k¹		1		WA	2
rs148365123^1,2		--	55924169(+)	`TGGGGC/TCTTGG`	1	--	us2k¹		0	--	--	--	--
rs141582080^1,2		--	55924179(+)	`GAGAAC/TCTTTG`	1	--	us2k¹		0	--	--	--	--
rs186719059^1,2		--	55924264(+)	`GGATGC/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs150494576^1,2		--	55924267(+)	`TGTGGA/GTGGGG`	1	--	us2k¹		0	--	--	--	--
rs191179235^1,2		--	55924324(+)	`CTGCTC/GGGGGC`	1	--	us2k¹		0	--	--	--	--
rs183997171^1,2		--	55924325(+)	`TGCTCA/GGGGCA`	1	--	us2k¹		0	--	--	--	--
rs118053626^1,2	F,	--	55924327(+)	`CTCGGG/CGCACC`	1	--	us2k¹		1		NA	120
rs186861907^1,2		--	55924329(+)	`CGGGGC/TACCTT`	1	--	us2k¹		0	--	--	--	--
rs6123692^1,2	A,	--	55924332(+)	`ggcacC/Tttcca`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for RAE1 (55926066 - 55954267 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAE1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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RAE1 for disorders           About GeneDecksing

OMIM gene information: 603343    OMIM disorders: --

5 diseases for RAE1:    About MalaCards

influenza ischemia neuroblastoma hepatitis

neuronitis

1 Novoseek disease relationship for RAE1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	7	11562472 (4)

Human Genome Epidemiology (HuGE) Navigator: RAE1 (1 document)

Export disorders for RAE1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAE1 gene, integrated from 9 sources (see all 60):
(articles sorted by number of sources associating them with RAE1)

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The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. (PubMed id 9370289)^{1, 2, 3, 9} Bharathi A....Dhar R. (1997)
mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. (PubMed id 9256445)^{1, 2, 3} Kraemer D.M. and Blobel G. (1997)
Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PubMed id 20498086)^{1, 2} Ren Y....Hoelz A. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. (PubMed id 11352911)^{1, 9} Wang X....van Deursen J.M. (2001)
Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. (PubMed id 8982867)^{1, 9} Nomura M....Shimada K. (1996)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
RAE-1, a novel PHR binding protein, is required for ax on termination and synapse formation in Caenorhabditis elegans. (PubMed id 22357847)¹ Grill B....Garner C.C. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 8480	HGNC: 9828	AceView: RAE1	Ensembl:ENSG00000101146	euGenes: HUgn8480
ECgene: RAE1	Kegg: 8480	H-InvDB: RAE1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAE1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for RAE1 gene
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Patent Information for RAE1 gene:
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GeneCards and IP:
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RAE1 RNA export 1 homolog (S. pombe)

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RAE1 RNA export 1 homolog (S. pombe)

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