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RAE1 Gene

protein-coding   GIFtS: 62
GCID: GC20P055926

Ribonucleic Acid Export 1

(Previous names: RAE1 (RNA export 1, S.pombe) homolog, RAE1 RNA export 1...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ribonucleic Acid Export 11 2     dJ481F12.32
MRNA-Associated Protein Mrnp 412 3     dJ800J21.12
Rae1 Protein Homolog2 3     Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa
(Kraemer)2
MRNP412 3     Migration-Inducing Gene 142
RAE1 (RNA Export 1, S.Pombe) Homolog1     MRNA Export Factor2
RAE1 RNA Export 1 Homolog (S. Pombe)1     MRNA Export Protein2
MIG142     MRNA-Binding Protein, 41-KD2
Mnrp412     RAE1 RNA Export 1 Homolog2

External Ids:    HGNC: 98281   Entrez Gene: 84802   Ensembl: ENSG000001011467   OMIM: 6033435   UniProtKB: P784063   

Export aliases for RAE1 gene to outside databases

Previous GC identifers: GC20P055654 GC20P056564 GC20P056611 GC20P055359 GC20P052708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAE1 Gene:
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result
in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in
RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has
been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures
throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or
indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding
the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAE1 Gene:
RAE1 (ribonucleic acid export 1) is a protein-coding gene. Diseases associated with RAE1 include stomatitis, and brain cancer. GO annotations related to this gene include microtubule binding and RNA binding. An important paralog of this gene is BUB3.

UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406
Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching
cytoplasmic mRNPs to the cytoskeleton

Gene Wiki entry for RAE1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NT_011362.11  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAE1 gene promoter:
         CBF-A   CBF-B   POU2F1   POU2F1a   IRF-1   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAE1 promoter sequence
   Search Chromatin IP Primers for RAE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.31   Ensembl cytogenetic band:  20q13.31   HGNC cytogenetic band: 20q13.31

RAE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAE1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P055926:  view genomic region     (about GC identifiers)

Start:
55,926,066 bp from pter      End:
55,954,267 bp from pter
Size:
28,202 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406 (See protein sequence)
Recommended Name: mRNA export factor  
Size: 368 amino acids; 40968 Da
Subunit: Interacts with NUP98
1 PDB 3D structure from and Proteopedia for RAE1:
3MMY (3D)    
Secondary accessions: A8K882 O15306 Q3SYL7 Q5TCH8 Q6V708 Q9H100 Q9NQM6

Explore the universe of human proteins at neXtProt for RAE1: NX_P78406

Explore proteomics data for RAE1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys154, Lys252, Lys340, Lys350
  • Modification sites at PhosphoSitePlus

  • See RAE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001015885.1  NP_003601.1  

    ENSEMBL proteins: 
     ENSP00000379182   ENSP00000360286   ENSP00000432609   ENSP00000432698   ENSP00000392097  
     ENSP00000393264   ENSP00000379181   ENSP00000402924  
    Reactome Protein details: P78406

    RAE1 Human Recombinant Protein Products:

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    RAE1 Antibody Products:

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    Abcam antibodies for RAE1 (Q3SYL7, P78406)
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    ThermoFisher Antibodies for RAE1
    LSBio Antibodies in human, mouse, rat for RAE1

    RAE1 Assay Products:

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    Cloud-Clone Corp. ELISAs for RAE1
    Cloud-Clone Corp. CLIAs for RAE1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P78406

    ProtoNet protein and cluster: P78406

    1 Blocks protein domain: IPB001680 G-protein beta WD-40 repeat signature

    UniProtKB/Swiss-Prot: RAE1L_HUMAN, P78406
    Similarity: Belongs to the WD repeat rae1 family
    Similarity: Contains 7 WD repeats


    RAE1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAE1L_HUMAN, P78406
    Function: Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching
    cytoplasmic mRNPs to the cytoskeleton

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS9256445
    GO:0005515protein binding ----
    GO:0008017microtubule binding ISS15851029
         
    RAE1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for RAE1:
     Increased HPV18 LCR reporter a  Nuclear 40S maturation defects  Nuclear 60S biogenesis defects  Nucleolar pre-40S maturation d 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rae1):
     adipose tissue  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     integument  mortality/aging  muscle  skeleton  tumorigenesis 
     vision/eye 

    RAE1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rae1tm1Jvd for RAE1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAE1

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAE1:
    hsa-mir-26b-5p (MIRT029494), hsa-mir-15b-5p (MIRT046487), hsa-mir-34a-5p (MIRT025213), hsa-mir-185-5p (MIRT045362), hsa-mir-361-5p (MIRT044107)

    Block miRNA regulation of human, mouse, rat RAE1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAE1 (see all 13):
    hsa-miR-34b* hsa-miR-34c-5p hsa-miR-3673 hsa-miR-520d-5p hsa-miR-449b hsa-miR-449a hsa-miR-519e* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAE1
    Predesigned siRNA for gene silencing in human, mouse, rat RAE1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for RAE1 (see all 12)
    OriGene ORF clones in mouse, rat for RAE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAE1 (NM_003610)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAE1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RAE1
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAE1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAE1L_HUMAN, P78406: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005635nuclear envelope TAS--
    GO:0005640nuclear outer membrane TAS9256445
    GO:0005643nuclear pore TAS10209021
    GO:0005730nucleolus IDA--

    RAE1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAE1 About   (see all 15)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Regulation of Glucokinase by Glucokinase Regulatory Protein
    Transport of the SLBP Dependant Mature mRNA0.92
    Export of Viral Ribonucleoproteins from Nucleus0.88
    Transport of Mature mRNAs Derived from Intronless Transcripts0.92
    Transport of Ribonucleoproteins into the Host Nucleus0.88
    Transport of the SLBP independent Mature mRNA0.91
    Regulation of Glucokinase by Glucokinase Regulatory Protein0.87
    Nuclear import of Rev protein0.91
    Glucose transport0.87
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Host Interactions of HIV factors0.60
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    5Transport of Mature Transcript to Cytoplasm
    Transport of Mature Transcript to Cytoplasm0.93
    Transport of Mature mRNA derived from an Intron-Containing Transcript0.93

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected Reactome Pathways for RAE1 (see all 6)
        Rev-mediated nuclear export of HIV RNA
    Regulation of Glucokinase by Glucokinase Regulatory Protein
    Nuclear import of Rev protein
    Nuclear Pore Complex (NPC) Disassembly
    Vpr-mediated nuclear import of PICs


    2 Kegg Pathways  (Kegg details for RAE1):
        RNA transport
    Influenza A


    RAE1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAE1
    Interactions:

        GeneGlobe Interaction Network for RAE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAE1 (P784062, 3 ENSP000003602864) via UniProtKB, MINT, STRING, and/or I2D (see all 857)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NXF1Q9UBU92, 3, ENSP000002941724MINT-14382 MINT-14383 I2D: score=3 STRING: ENSP00000294172
    BUB1O436832, 3, ENSP000003025304MINT-7945693 I2D: score=3 STRING: ENSP00000302530
    NUP98P529482, 3, ENSP000003160324MINT-7294477 I2D: score=3 STRING: ENSP00000316032
    NUP155O756942, 3, ENSP000002314984MINT-7945693 I2D: score=2 STRING: ENSP00000231498
    COPS6Q7L5N12, 3, ENSP000003041024MINT-7945693 I2D: score=1 STRING: ENSP00000304102
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006406mRNA export from nucleus TAS10209021
    GO:0007077mitotic nuclear envelope disassembly TAS--
    GO:0008645hexose transport TAS--

    RAE1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAE1 (RAE1L)

    1 Novoseek inferred chemical compound relationship for RAE1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoic acid 35.6 4 11562472 (2), 12594837 (1), 11825567 (1)



    RAE1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RAE1 gene (2 alternative transcripts): 
    NM_001015885.1  NM_003610.3  

    Unigene Cluster for RAE1:

    RAE1 RNA export 1 homolog (S. pombe)
    Hs.371698  [show with all ESTs]
    Unigene Representative Sequence: AY349350
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395841(uc002xyg.3) ENST00000371242 ENST00000527947(uc010gis.1 uc010git.1)
    ENST00000492498 ENST00000411894 ENST00000429339 ENST00000395840(uc002xyi.3)
    ENST00000452119 ENST00000462438
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAE1 (see all 13):
    hsa-miR-34b* hsa-miR-34c-5p hsa-miR-3673 hsa-miR-520d-5p hsa-miR-449b hsa-miR-449a hsa-miR-519e* hsa-miR-515-5p
    SwitchGear 3'UTR luciferase reporter plasmidRAE1 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene clones in human, mouse for RAE1 (see all 12)
    OriGene ORF clones in mouse, rat for RAE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): RAE1 (NM_003610)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAE1
    Primer
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    OriGene qPCR primer pairs and template standards for RAE1
    OriGene qSTAR qPCR primer pairs in human, mouse for RAE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAE1
      QuantiTect SYBR Green Assays in human, mouse, rat RAE1
      QuantiFast Probe-based Assays in human, mouse, rat RAE1

    Additional mRNA sequence: 

    AK292247.1 AK307966.1 AK309069.1 AK309743.1 AY336091.1 AY349350.1 BC103754.1 BC106923.1 
    BC106924.1 U84720.1 

    24 DOTS entries:

    DT.318678  DT.95146479  DT.92448671  DT.100822112  DT.100822113  DT.120808322  DT.100822110  DT.452002 
    DT.97862107  DT.120808295  DT.120808344  DT.120808294  DT.92448673  DT.120808334  DT.91943371  DT.40116088 
    DT.75150463  DT.99999666  DT.100680340  DT.100724008  DT.95076500  DT.95313183  DT.95340794  DT.97862108 

    Selected AceView cDNA sequences (see all 448):

    AI651076 CR605228 BM545685 AK126024 BI766896 BU192149 BM989388 BM981048 
    BM721346 BG476020 BQ020168 BG281059 CR621755 BM781961 BE254782 CR622985 
    AI362959 BQ880415 BQ070388 BU784147 AI863625 BM701854 BX279754 BU167191 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
    SP1:                                      -     -     -     -                                                                             -     -               
    SP2:                                                  -     -                                                                             -     -               
    SP3:                                      -     -     -     -                                                                             -     -     -         
    SP4:                                      -     -     -     -                 -                                                                                 
    SP5:                                -     -     -     -     -                                                                                                   

    ExUns: 14a · 14b ^ 15a · 15b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for RAE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTCAACC
    RAE1 Expression
    About this image

    RAE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.371698
        Custom PCR Arrays for RAE1
    Primer
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    OriGene qPCR primer pairs and template standards for RAE1
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    QuantiTect SYBR Green Assays in human, mouse, rat RAE1
    QuantiFast Probe-based Assays in human, mouse, rat RAE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAE1 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rae11 , 5 RAE1 RNA export 1 homolog (S. pombe)1, 5 88.68(n)1
    98.64(a)1
      2 (95.66 cM)5
    666791  NM_175112.51  NP_780321.11 
     1730001175 
    chicken
    (Gallus gallus)
    Aves RAE11 RAE1 RNA export 1 homolog (S. pombe) 83.33(n)
    95.38(a)
      419324  NM_001030868.2  NP_001026039.2 
    lizard
    (Anolis carolinensis)
    Reptilia RAE16
    ribonucleic acid export 1
    94(a)
    1 ↔ 1
    GL343217.1(1189864-1210621)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.242742 Xenopus laevis Rae1/Gle2 (Rae1/Gle2) mRNA, complete more 79.75(n)    AY256464.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564492 similar to RAE1 RNA export 1 homolog (S. pombe) 78.45(n)   393973  BC049445.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98623
    Rae11
    Rae11 68(a)
    (best of 2)3
    62.89(n)1
    69.77(a)1
      57F63
    374671  NM_137753.21  NP_611597.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rae-11 rae-1 51.1(n)
    51.92(a)
      172864  NM_060249.3  NP_492650.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes GLE2(YER107C)4
    GLE21
    Component of the Nup82 subcomplex of the nuclear pore more4
    GLE21
    51.13(n)1
    44.07(a)1
      5(374545-373448)4
    8568441, 4  NP_011033.31  NP_011033.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G806701 AT1G80670 56.56(n)
    54.35(a)
      844406  NM_106715.4  NP_178182.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01768001 Os08g0176800 56.97(n)
    54.8(a)
      4344798  NM_001067654.1  NP_001061119.1 


    ENSEMBL Gene Tree for RAE1 (if available)
    TreeFam Gene Tree for RAE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAE1 gene
    BUB32  
    1 SIMAP similar gene for RAE1 using alignment to 6 protein entries:     RAE1L_HUMAN (see all proteins):
    BUB3

    RAE1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAE1 (see all 682)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1137370691,2
    C--55924153(+) TATCTG/AGCTAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1483651231,2
    --55924169(+) TGGGGC/TCTTGG 1 -- us2k10--------
    rs1415820801,2
    --55924179(+) GAGAAC/TCTTTG 1 -- us2k10--------
    rs1867190591,2
    --55924264(+) GGATGC/TGGGTG 1 -- us2k10--------
    rs1504945761,2
    --55924267(+) TGTGGA/GTGGGG 1 -- us2k10--------
    rs1911792351,2
    --55924324(+) CTGCTC/GGGGGC 1 -- us2k10--------
    rs1839971711,2
    C--55924325(+) TGCTCA/GGGGCA 1 -- us2k10--------
    rs1180536261,2
    F--55924327(+) CTCGGG/CGCACC 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1868619071,2
    --55924329(+) CGGGGC/TACCTT 1 -- us2k10--------
    rs61236921,2
    F,A--55924332(+) ggcacC/Tttcca 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAE1 (55926066 - 55954267 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for RAE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3424CNV Insertion18451855
    nsv459027CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAE1
    DNA2.0 Custom Variant and Variant Library Synthesis for RAE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603343    OMIM disorders: --

    9 diseases for RAE1:    
    About MalaCards
    stomatitis    brain cancer    influenza    ischemia
    neuroblastoma    hiv-1    hepatitis    malaria
    neuronitis


    RAE1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RAE1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 7 11562472 (4)

    Human Genome Epidemiology (HuGE) Navigator: RAE1 (1 document)

    Export disorders for RAE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAE1 gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with RAE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. (PubMed id 9370289)1, 2, 3, 9 Bharathi A....Dhar R. (Gene 1997)
    2. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. (PubMed id 9256445)1, 2, 3 Kraemer D.M. and Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PubMed id 20498086)1, 2 Ren Y.... Hoelz A. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. (PubMed id 11352911)1, 9 Wang X....van Deursen J.M. (J. Biol. Chem. 2001)
    8. Genomic structures and characterization of Rae1 family members encoding GPI-anchored cell surface proteins and expressed predominantly in embryonic mouse brain. (PubMed id 8982867)1, 9 Nomura M....Shimada K. (J. Biochem. 1996)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. 14-3-3 proteins sequester a pool of soluble TRIM32 ubiquitin ligase to repress autoubiquitylation and cytoplasmic body formation. (PubMed id 23444366)1 Ichimura T....Hachiya N. (J. Cell. Sci. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8480 HGNC: 9828 AceView: RAE1 Ensembl:ENSG00000101146 euGenes: HUgn8480
    ECgene: RAE1 Kegg: 8480 H-InvDB: RAE1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAE1 gene:
    Search GeneIP for patents involving RAE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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