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Aliases for RAE1 Gene

Aliases for RAE1 Gene

  • Ribonucleic Acid Export 1 2 3 5
  • Rae1 Protein Homolog 3 4
  • MRNP41 3 4
  • Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa (Kraemer) 3
  • RAE1 (RNA Export 1, S.Pombe) Homolog 2
  • RAE1 RNA Export 1 Homolog (S. Pombe) 2
  • MRNA-Associated Protein MRNP 41 3
  • MRNA-Associated Protein Mrnp 41 4
  • MRNA-Binding Protein, 41-KD 3
  • Migration-Inducing Gene 14 3
  • RAE1 RNA Export 1 Homolog 3
  • MRNA Export Protein 3
  • MRNA Export Factor 3
  • DJ481F12.3 3
  • DJ800J21.1 3
  • Mnrp41 3
  • MIG14 3

External Ids for RAE1 Gene

Previous GeneCards Identifiers for RAE1 Gene

  • GC20P055654
  • GC20P056564
  • GC20P056611
  • GC20P055359
  • GC20P055926
  • GC20P052708

Summaries for RAE1 Gene

Entrez Gene Summary for RAE1 Gene

  • Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAE1 Gene

RAE1 (Ribonucleic Acid Export 1) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Transport of the SLBP independent Mature mRNA. GO annotations related to this gene include RNA binding and microtubule binding. An important paralog of this gene is BUB3.

UniProtKB/Swiss-Prot for RAE1 Gene

  • Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Gene Wiki entry for RAE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAE1 Gene

Genomics for RAE1 Gene

Regulatory Elements for RAE1 Gene

Enhancers for RAE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F057502 1 Ensembl ENCODE 11.6 +152.3 152257 1.3 IKZF1 EED JUNB ETV6 KDM1A SPI1 MTND1P9 MTRNR2L3 LOC100291105 RBM38 RAE1 CTCFL PCK1 ZBP1 RPL39P39 SPO11
GH20F057495 1.1 Ensembl ENCODE 11.2 +144.3 144276 0.6 ELF3 HDAC1 PKNOX1 SIN3A ZBTB40 ZSCAN9 RAD21 ZEB1 RFX5 ZNF121 LOC100291105 RBM38 MTND1P9 MTRNR2L3 RAE1 CTCFL PCK1 HMGB1P1
GH20F057498 1.2 Ensembl ENCODE 11.2 +147.9 147891 1.0 CTCF ZNF654 RAD21 GLIS2 GLIS1 EED IKZF1 SMC3 PRDM1 MYC LOC100291105 RBM38 MTRNR2L3 MTND1P9 RAE1 CTCFL PCK1 HMGB1P1
GH20F058305 1.2 FANTOM5 ENCODE 9.9 +957.7 957669 5.4 PKNOX1 ATF1 CREB3L1 SIN3A YBX1 ZNF48 YY1 GLIS2 ELK1 KLF7 NELFCD RAE1 RAB22A PPP4R1L STX16 ANKRD60
GH20F057167 0.8 Ensembl ENCODE 5.5 -182.6 -182642 2.2 KLF1 PKNOX1 KLF17 FEZF1 ZIC2 HIC1 ZNF324 CTBP1 ZNF366 SCRT2 RAE1 LOC105372686 BMP7-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAE1 on UCSC Golden Path with GeneCards custom track

Promoters for RAE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000010399 390 1601 ATF1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 GLIS2 ELK1

Genomic Location for RAE1 Gene

Chromosome:
20
Start:
57,351,010 bp from pter
End:
57,379,211 bp from pter
Size:
28,202 bases
Orientation:
Plus strand

Genomic View for RAE1 Gene

Genes around RAE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAE1 Gene

Proteins for RAE1 Gene

  • Protein details for RAE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78406-RAE1L_HUMAN
    Recommended name:
    mRNA export factor
    Protein Accession:
    P78406
    Secondary Accessions:
    • A8K882
    • O15306
    • Q3SYL7
    • Q5TCH8
    • Q6V708
    • Q9H100
    • Q9NQM6

    Protein attributes for RAE1 Gene

    Size:
    368 amino acids
    Molecular mass:
    40968 Da
    Quaternary structure:
    • Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).

    Three dimensional structures from OCA and Proteopedia for RAE1 Gene

neXtProt entry for RAE1 Gene

Post-translational modifications for RAE1 Gene

  • Ubiquitination at Lys 154, Lys 252, Lys 340, and Lys 350
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAE1 Gene

Domains & Families for RAE1 Gene

Gene Families for RAE1 Gene

Graphical View of Domain Structure for InterPro Entry

P78406

UniProtKB/Swiss-Prot:

RAE1L_HUMAN :
  • Belongs to the WD repeat rae1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat rae1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with RAE1: view

Function for RAE1 Gene

Molecular function for RAE1 Gene

UniProtKB/Swiss-Prot Function:
Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Gene Ontology (GO) - Molecular Function for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 9256445
GO:0008017 microtubule binding ISS 15851029
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with RAE1: view
genes like me logo Genes that share phenotypes with RAE1: view

Animal Models for RAE1 Gene

MGI Knock Outs for RAE1:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAE1 Gene

Localization for RAE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAE1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAE1 Gene COMPARTMENTS Subcellular localization image for RAE1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,TAS --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA 9256445
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA,TAS --
genes like me logo Genes that share ontologies with RAE1: view

Pathways & Interactions for RAE1 Gene

SuperPathways for RAE1 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with RAE1: view

Pathways by source for RAE1 Gene

Gene Ontology (GO) - Biological Process for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
GO:0006606 protein import into nucleus IBA --
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with RAE1: view

No data available for SIGNOR curated interactions for RAE1 Gene

Drugs & Compounds for RAE1 Gene

(1) Additional Compounds for RAE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAE1: view

Transcripts for RAE1 Gene

Unigene Clusters for RAE1 Gene

RAE1 RNA export 1 homolog (S. pombe):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: -
SP10: - - - - - - - - -
SP11:
SP12: - - - - - - -

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RAE1 Gene

GeneLoc Exon Structure for
RAE1
ECgene alternative splicing isoforms for
RAE1

Expression for RAE1 Gene

mRNA expression in normal human tissues for RAE1 Gene

Protein differential expression in normal tissues from HIPED for RAE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1) and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAE1 Gene



Protein tissue co-expression partners for RAE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAE1 Gene:

RAE1

SOURCE GeneReport for Unigene cluster for RAE1 Gene:

Hs.371698
genes like me logo Genes that share expression patterns with RAE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAE1 Gene

Orthologs for RAE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAE1 34 35
  • 98.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RAE1 35
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAE1 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAE1 34 35
  • 92.03 (n)
dog
(Canis familiaris)
Mammalia RAE1 34 35
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Rae1 34 16 35
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Rae1 34
  • 86.41 (n)
chicken
(Gallus gallus)
Aves RAE1 34 35
  • 83.33 (n)
lizard
(Anolis carolinensis)
Reptilia RAE1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rae1 34
  • 78.71 (n)
Str.7223 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24274 34
zebrafish
(Danio rerio)
Actinopterygii rae1 34 35
  • 77.72 (n)
zgc56449 34
fruit fly
(Drosophila melanogaster)
Insecta CG9862 36
  • 68 (a)
Rae1 34 35
  • 62.89 (n)
CG12782 36 35
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012373 34
  • 63.78 (n)
worm
(Caenorhabditis elegans)
Secernentea rae-1 34 35
  • 51.1 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20703g 34
  • 52.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLE2 34 35 37
  • 51.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL301C 34
  • 47.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80670 34
  • 56.56 (n)
rice
(Oryza sativa)
Liliopsida Os08g0176800 34
  • 56.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1899 35
  • 73 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rae1 34
  • 52.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04288 34
  • 48.48 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6749 34
Species where no ortholog for RAE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAE1 Gene

ENSEMBL:
Gene Tree for RAE1 (if available)
TreeFam:
Gene Tree for RAE1 (if available)

Paralogs for RAE1 Gene

Paralogs for RAE1 Gene

(1) SIMAP similar genes for RAE1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAE1: view

Variants for RAE1 Gene

Sequence variations from dbSNP and Humsavar for RAE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs386352355 Uncertain significance 57,366,839(+) TGGAT(C/G)AAAGC reference, missense
rs1061219 -- 57,378,066(+) AATGC(A/G)GCCGA reference, synonymous-codon, utr-variant-3-prime
rs1061281 -- 57,377,915(+) ATGTT(A/T)CCAGT intron-variant
rs10625159 -- 57,352,167(+) GTATA(-/ACTT)AAATA intron-variant, upstream-variant-2KB
rs111244902 -- 57,372,063(+) CATTA(A/G)ACAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAE1 Gene

Variant ID Type Subtype PubMed ID
nsv1055983 CNV gain 25217958
nsv3424 CNV insertion 18451855
nsv459027 CNV loss 19166990
nsv586311 CNV loss 21841781
nsv965892 CNV duplication 23825009

Variation tolerance for RAE1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAE1 Gene

Disorders for RAE1 Gene

Relevant External Links for RAE1

Human Genome Epidemiology (HuGE) Navigator
RAE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAE1

No disorders were found for RAE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAE1 Gene

Publications for RAE1 Gene

  1. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. (PMID: 9370289) Bharathi A. … Dhar R. (Gene 1997) 2 3 4 22 64
  2. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. (PMID: 9256445) Kraemer D.M. … Blobel G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 64
  3. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. (PMID: 22357847) Grill B. … Garner C.C. (J. Neurosci. 2012) 3 4 64
  4. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PMID: 20498086) Ren Y. … Hoelz A. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 4 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for RAE1 Gene

Sources for RAE1 Gene

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