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Aliases for RAE1 Gene

Aliases for RAE1 Gene

  • Ribonucleic Acid Export 1 2 3
  • Rae1 Protein Homolog 3 4
  • MRNP41 3 4
  • Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa (Kraemer) 3
  • RAE1 (RNA Export 1, S.Pombe) Homolog 2
  • RAE1 RNA Export 1 Homolog (S. Pombe) 2
  • MRNA-Associated Protein MRNP 41 3
  • MRNA-Associated Protein Mrnp 41 4
  • MRNA-Binding Protein, 41-KD 3
  • Migration-Inducing Gene 14 3
  • RAE1 RNA Export 1 Homolog 3
  • MRNA Export Protein 3
  • DJ481F12.3 3
  • DJ800J21.1 3
  • Mnrp41 3
  • MIG14 3

External Ids for RAE1 Gene

Previous GeneCards Identifiers for RAE1 Gene

  • GC20P055654
  • GC20P056564
  • GC20P056611
  • GC20P055359
  • GC20P055926
  • GC20P052708

Summaries for RAE1 Gene

Entrez Gene Summary for RAE1 Gene

  • Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAE1 Gene

RAE1 (Ribonucleic Acid Export 1) is a Protein Coding gene. Among its related pathways are Immune System and Infectious disease. GO annotations related to this gene include RNA binding and microtubule binding. An important paralog of this gene is BUB3.

UniProtKB/Swiss-Prot for RAE1 Gene

  • Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton

Gene Wiki entry for RAE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAE1 Gene

Genomics for RAE1 Gene

Regulatory Elements for RAE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for RAE1 Gene

Chromosome:
20
Start:
57,351,010 bp from pter
End:
57,379,211 bp from pter
Size:
28,202 bases
Orientation:
Plus strand

Genomic View for RAE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for RAE1 Gene

Proteins for RAE1 Gene

  • Protein details for RAE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78406-RAE1L_HUMAN
    Recommended name:
    mRNA export factor
    Protein Accession:
    P78406
    Secondary Accessions:
    • A8K882
    • O15306
    • Q3SYL7
    • Q5TCH8
    • Q6V708
    • Q9H100
    • Q9NQM6

    Protein attributes for RAE1 Gene

    Size:
    368 amino acids
    Molecular mass:
    40968 Da
    Quaternary structure:
    • Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).

    Three dimensional structures from OCA and Proteopedia for RAE1 Gene

neXtProt entry for RAE1 Gene

Proteomics data for RAE1 Gene at MOPED

Post-translational modifications for RAE1 Gene

  • Ubiquitination at Lys 154, Lys 252, Lys 340, and Lys 350
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAE1 Gene

Domains & Families for RAE1 Gene

Gene Families for RAE1 Gene

Graphical View of Domain Structure for InterPro Entry

P78406

UniProtKB/Swiss-Prot:

RAE1L_HUMAN :
  • Belongs to the WD repeat rae1 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat rae1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with RAE1: view

Function for RAE1 Gene

Molecular function for RAE1 Gene

UniProtKB/Swiss-Prot Function:
Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton

Gene Ontology (GO) - Molecular Function for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 9256445
GO:0005515 protein binding --
GO:0008017 microtubule binding ISS 15851029
genes like me logo Genes that share ontologies with RAE1: view
genes like me logo Genes that share phenotypes with RAE1: view

Animal Models for RAE1 Gene

MGI Knock Outs for RAE1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAE1 Gene

Localization for RAE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAE1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAE1 Gene COMPARTMENTS Subcellular localization image for RAE1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4

Gene Ontology (GO) - Cellular Components for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005635 nuclear envelope TAS --
GO:0005640 nuclear outer membrane TAS 9256445
GO:0005643 nuclear pore TAS 9256445
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with RAE1: view

Pathways & Interactions for RAE1 Gene

SuperPathways for RAE1 Gene

Superpath Contained pathways
1 Transport of Ribonucleoproteins into the Host Nucleus
2 Infectious disease
.53
3 Cell Cycle, Mitotic
.62
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with RAE1: view

Pathways by source for RAE1 Gene

2 KEGG pathways for RAE1 Gene

Gene Ontology (GO) - Biological Process for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus TAS 10209021
GO:0007077 mitotic nuclear envelope disassembly TAS --
GO:0008033 tRNA processing TAS --
genes like me logo Genes that share ontologies with RAE1: view

No data available for SIGNOR curated interactions for RAE1 Gene

Drugs & Compounds for RAE1 Gene

(1) Additional Compounds for RAE1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
genes like me logo Genes that share compounds with RAE1: view

Transcripts for RAE1 Gene

Unigene Clusters for RAE1 Gene

RAE1 RNA export 1 homolog (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: -
SP10: - - - - - - - - -
SP11:
SP12: - - - - - - -

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RAE1 Gene

GeneLoc Exon Structure for
RAE1
ECgene alternative splicing isoforms for
RAE1

Expression for RAE1 Gene

mRNA expression in normal human tissues for RAE1 Gene

Protein differential expression in normal tissues from HIPED for RAE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1) and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAE1 Gene



SOURCE GeneReport for Unigene cluster for RAE1 Gene Hs.371698

genes like me logo Genes that share expression patterns with RAE1: view

Protein tissue co-expression partners for RAE1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAE1 Gene

Orthologs for RAE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAE1 36
  • 99 (a)
OneToOne
RAE1 35
  • 98.46 (n)
  • 98.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia RAE1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rae1 36
  • 99 (a)
OneToOne
Rae1 16
Rae1 35
  • 88.68 (n)
  • 98.64 (a)
oppossum
(Monodelphis domestica)
Mammalia RAE1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAE1 36
  • 99 (a)
OneToOne
RAE1 35
  • 91.85 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia RAE1 36
  • 99 (a)
OneToOne
RAE1 35
  • 92.03 (n)
  • 98.64 (a)
rat
(Rattus norvegicus)
Mammalia Rae1 35
  • 86.41 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves RAE1 36
  • 82 (a)
OneToOne
RAE1 35
  • 83.33 (n)
  • 95.38 (a)
lizard
(Anolis carolinensis)
Reptilia RAE1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24274 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7223 35
rae1 35
  • 78.71 (n)
  • 92.93 (a)
zebrafish
(Danio rerio)
Actinopterygii rae1 36
  • 91 (a)
OneToOne
zgc56449 35
rae1 35
  • 77.72 (n)
  • 90.76 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rae1 36
  • 69 (a)
OneToMany
CG12782 36
  • 36 (a)
OneToMany
Rae1 35
  • 62.89 (n)
  • 69.77 (a)
CG9862 37
  • 68 (a)
CG12782 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012373 35
  • 63.78 (n)
  • 69.83 (a)
worm
(Caenorhabditis elegans)
Secernentea rae-1 36
  • 51 (a)
OneToOne
rae-1 35
  • 51.1 (n)
  • 51.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLE2 38
GLE2 36
  • 41 (a)
OneToMany
GLE2 35
  • 51.13 (n)
  • 44.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20703g 35
  • 52.08 (n)
  • 45.9 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL301C 35
  • 47.55 (n)
  • 42.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80670 35
  • 56.56 (n)
  • 54.35 (a)
rice
(Oryza sativa)
Liliopsida Os08g0176800 35
  • 56.97 (n)
  • 54.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1899 36
  • 73 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rae1 35
  • 52.45 (n)
  • 49.57 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04288 35
  • 48.48 (n)
  • 43.99 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6749 35
Species with no ortholog for RAE1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAE1 Gene

ENSEMBL:
Gene Tree for RAE1 (if available)
TreeFam:
Gene Tree for RAE1 (if available)

Paralogs for RAE1 Gene

Paralogs for RAE1 Gene

(1) SIMAP similar genes for RAE1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAE1: view

Variants for RAE1 Gene

Sequence variations from dbSNP and Humsavar for RAE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs167879 -- 57,362,310(+) TATCA(C/T)CTGTA intron-variant
rs911899 -- 57,355,185(+) TCAAC(A/G)TTAAA intron-variant
rs911900 -- 57,355,204(+) CAGAT(C/T)TGCCT intron-variant
rs911901 -- 57,377,131(+) TGAGA(A/G)TTAGT intron-variant
rs1061219 -- 57,378,066(+) AATGC(A/G)GCCGA reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAE1 Gene

Variant ID Type Subtype PubMed ID
nsv459027 CNV Loss 19166990
nsv3424 CNV Insertion 18451855

Variation tolerance for RAE1 Gene

Residual Variation Intolerance Score: 24.75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAE1 Gene

HapMap Linkage Disequilibrium report
RAE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAE1 Gene

Disorders for RAE1 Gene

Relevant External Links for RAE1

Human Genome Epidemiology (HuGE) Navigator
RAE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAE1
genes like me logo Genes that share disorders with RAE1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAE1 Gene

Publications for RAE1 Gene

  1. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of poly(A)+ RNA. (PMID: 9370289) Bharathi A. … Dhar R. (Gene 1997) 2 23 67
  2. Direct interaction of the mouse cytomegalovirus m152/gp40 immunoevasin with RAE-1 isoforms. (PMID: 20166740) Zhi L. … Margulies D.H. (Biochemistry 2010) 23 67
  3. Promiscuity of MCMV immunoevasin of NKG2D: m138/fcr-1 down-modulates RAE-1epsilon in addition to MULT-1 and H60. (PMID: 19297023) ArapoviA8 J. … JonjiA8 S. (Mol. Immunol. 2009) 23 67
  4. Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. (PMID: 18753637) Nausch N. … Cerwenka A. (Blood 2008) 23 67
  5. A transmembrane-anchored rat RAE-1-like transcript as a ligand for NKR-P2, the rat ortholog of human and mouse NKG2D. (PMID: 16323246) Savithri B. … Khar A. (Eur. J. Immunol. 2006) 23 67

Products for RAE1 Gene

Sources for RAE1 Gene

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