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Aliases for RAE1 Gene

Aliases for RAE1 Gene

  • Ribonucleic Acid Export 1 2 3 5
  • Rae1 Protein Homolog 3 4
  • MRNP41 3 4
  • Homolog Of Yeast Rae1 (Bharathi) MRNA-Associated Protein Of 41 KDa (Kraemer) 3
  • RAE1 (RNA Export 1, S.Pombe) Homolog 2
  • RAE1 RNA Export 1 Homolog (S. Pombe) 2
  • MRNA-Associated Protein MRNP 41 3
  • MRNA-Associated Protein Mrnp 41 4
  • MRNA-Binding Protein, 41-KD 3
  • Migration-Inducing Gene 14 3
  • RAE1 RNA Export 1 Homolog 3
  • MRNA Export Protein 3
  • MRNA Export Factor 3
  • DJ481F12.3 3
  • DJ800J21.1 3
  • Mnrp41 3
  • MIG14 3

External Ids for RAE1 Gene

Previous GeneCards Identifiers for RAE1 Gene

  • GC20P055654
  • GC20P056564
  • GC20P056611
  • GC20P055359
  • GC20P055926
  • GC20P052708

Summaries for RAE1 Gene

Entrez Gene Summary for RAE1 Gene

  • Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAE1 Gene

RAE1 (Ribonucleic Acid Export 1) is a Protein Coding gene. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cell Cycle, Mitotic. GO annotations related to this gene include RNA binding and microtubule binding. An important paralog of this gene is BUB3.

UniProtKB/Swiss-Prot for RAE1 Gene

  • Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Gene Wiki entry for RAE1 Gene

Additional gene information for RAE1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAE1 Gene

Genomics for RAE1 Gene

Regulatory Elements for RAE1 Gene

Enhancers for RAE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H058305 1.7 FANTOM5 ENCODE dbSUPER 20.6 +957.7 957669 5 PKNOX1 FOXA2 SIN3A YBX1 YY1 ZNF143 ZNF207 FOS SP3 SP5 NELFCD RAE1 LOC101927932 RAB22A PPP4R1L STX16 ANKRD60
GH20H057715 1.5 Ensembl ENCODE dbSUPER 12.6 +366.6 366592 3 HDGF PKNOX1 ATF1 SIN3A YBX1 FEZF1 BRCA1 ZBTB7B GLIS2 ELK1 PPP4R1L RAE1 ENSG00000254419 LOC105372692 PMEPA1
GH20H057706 1.3 ENCODE dbSUPER 12.6 +357.9 357861 5 PKNOX1 ATF1 SIN3A BRCA1 ZBTB7B GLIS2 ELK1 ZNF143 ATF7 DEK RAE1 NKILA GC20M057649
GH20H058236 1.3 Ensembl ENCODE 12.5 +886.5 886544 2 SIN3A YBX1 ZBTB7B ZNF207 ZNF143 FOS RUNX3 SP5 MXD4 REST PPP4R1L RAE1 RAB22A ENSG00000254419 ANKRD60
GH20H057495 1.4 Ensembl ENCODE dbSUPER 11.2 +144.3 144270 0 HDAC1 ELF3 PKNOX1 RB1 ARNT SIN3A ZBTB40 ZSCAN9 RAD21 ZEB1 LOC100291105 RBM38 MTND1P9 MTRNR2L3 RAE1 CTCFL PCK1 HMGB1P1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAE1 on UCSC Golden Path with GeneCards custom track

Promoters for RAE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139218 290 1401 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 ZNF207 ZHX2 MXD4

Genomic Location for RAE1 Gene

Chromosome:
20
Start:
57,351,010 bp from pter
End:
57,379,211 bp from pter
Size:
28,202 bases
Orientation:
Plus strand

Genomic View for RAE1 Gene

Genes around RAE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAE1 Gene

Proteins for RAE1 Gene

  • Protein details for RAE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78406-RAE1L_HUMAN
    Recommended name:
    mRNA export factor
    Protein Accession:
    P78406
    Secondary Accessions:
    • A8K882
    • O15306
    • Q3SYL7
    • Q5TCH8
    • Q6V708
    • Q9H100
    • Q9NQM6

    Protein attributes for RAE1 Gene

    Size:
    368 amino acids
    Molecular mass:
    40968 Da
    Quaternary structure:
    • Interacts with NUMA1 (via N-terminal end of the coiled-coil domain); this interaction promotes spindle formation in mitosis (PubMed:17172455). Interacts with NUP98 (PubMed:20498086). Interacts with MYCBP2 (PubMed:22357847).

    Three dimensional structures from OCA and Proteopedia for RAE1 Gene

neXtProt entry for RAE1 Gene

Post-translational modifications for RAE1 Gene

  • Ubiquitination at Lys154, isoforms=252, isoforms=340, and isoforms=350
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for RAE1 Gene

Domains & Families for RAE1 Gene

Gene Families for RAE1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

P78406

UniProtKB/Swiss-Prot:

RAE1L_HUMAN :
  • Belongs to the WD repeat rae1 family.
Family:
  • Belongs to the WD repeat rae1 family.
genes like me logo Genes that share domains with RAE1: view

Function for RAE1 Gene

Molecular function for RAE1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.

Phenotypes From GWAS Catalog for RAE1 Gene

Gene Ontology (GO) - Molecular Function for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 9256445
GO:0005515 protein binding IPI 10668806
GO:0008017 microtubule binding ISS 15851029
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with RAE1: view
genes like me logo Genes that share phenotypes with RAE1: view

Animal Models for RAE1 Gene

MGI Knock Outs for RAE1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAE1 Gene

Localization for RAE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAE1 Gene

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle pole. Note=Recruited from interphase nuclei to spindle MTs during mitosis. {ECO:0000269 PubMed:17172455}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAE1 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus TAS,IDA --
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA,TAS 9256445
GO:0005737 cytoplasm TAS,IEA --
genes like me logo Genes that share ontologies with RAE1: view

Pathways & Interactions for RAE1 Gene

SuperPathway Contained pathways
1 Transport of the SLBP independent Mature mRNA
2 HIV Life Cycle
.45
3 Cell Cycle, Mitotic
.60
4 Mitotic Prophase
5 Influenza Viral RNA Transcription and Replication
genes like me logo Genes that share pathways with RAE1: view

Pathways by source for RAE1 Gene

Gene Ontology (GO) - Biological Process for RAE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery IBA --
GO:0006110 regulation of glycolytic process TAS --
GO:0006405 RNA export from nucleus IBA --
GO:0006406 mRNA export from nucleus TAS --
GO:0006409 tRNA export from nucleus TAS --
genes like me logo Genes that share ontologies with RAE1: view

No data available for SIGNOR curated interactions for RAE1 Gene

Drugs & Compounds for RAE1 Gene

(1) Additional Compounds for RAE1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAE1: view

Transcripts for RAE1 Gene

Unigene Clusters for RAE1 Gene

RAE1 RNA export 1 homolog (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAE1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAE1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^
SP1: - - - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - - - -
SP6:
SP7: - - - - - - - -
SP8:
SP9: -
SP10: - - - - - - - - -
SP11:
SP12: - - - - - - -

ExUns: 14a · 14b ^ 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for RAE1 Gene

GeneLoc Exon Structure for
RAE1
ECgene alternative splicing isoforms for
RAE1

Expression for RAE1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAE1 Gene

Protein differential expression in normal tissues from HIPED for RAE1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.1) and Fetal ovary (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAE1 Gene



Protein tissue co-expression partners for RAE1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAE1 Gene:

RAE1

SOURCE GeneReport for Unigene cluster for RAE1 Gene:

Hs.371698

Evidence on tissue expression from TISSUES for RAE1 Gene

  • Nervous system(4.3)
  • Skin(2.4)
  • Lung(2.3)
genes like me logo Genes that share expression patterns with RAE1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAE1 Gene

Orthologs for RAE1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAE1 33 34
  • 98.46 (n)
oppossum
(Monodelphis domestica)
Mammalia RAE1 34
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAE1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAE1 33 34
  • 92.03 (n)
dog
(Canis familiaris)
Mammalia RAE1 33 34
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Rae1 33 16 34
  • 88.68 (n)
rat
(Rattus norvegicus)
Mammalia Rae1 33
  • 86.41 (n)
chicken
(Gallus gallus)
Aves RAE1 33 34
  • 83.33 (n)
lizard
(Anolis carolinensis)
Reptilia RAE1 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rae1 33
  • 78.71 (n)
Str.7223 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24274 33
zebrafish
(Danio rerio)
Actinopterygii rae1 33 34
  • 77.72 (n)
zgc56449 33
fruit fly
(Drosophila melanogaster)
Insecta CG9862 35
  • 68 (a)
Rae1 33 34
  • 62.89 (n)
CG12782 35 34
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012373 33
  • 63.78 (n)
worm
(Caenorhabditis elegans)
Secernentea rae-1 34 33
  • 51.1 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20703g 33
  • 52.08 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLE2 33 34 36
  • 51.13 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL301C 33
  • 47.55 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G80670 33
  • 56.56 (n)
rice
(Oryza sativa)
Liliopsida Os08g0176800 33
  • 56.97 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1899 34
  • 73 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rae1 33
  • 52.45 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU04288 33
  • 48.48 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6749 33
Species where no ortholog for RAE1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAE1 Gene

ENSEMBL:
Gene Tree for RAE1 (if available)
TreeFam:
Gene Tree for RAE1 (if available)

Paralogs for RAE1 Gene

Paralogs for RAE1 Gene

(1) SIMAP similar genes for RAE1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with RAE1: view

Variants for RAE1 Gene

Sequence variations from dbSNP and Humsavar for RAE1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs386352355 Uncertain significance 57,366,839(+) TGGAT(C/G)AAAGC reference, missense
rs1000066145 -- 57,377,742(+) TAAAA(G/T)GGGGC intron-variant
rs1000151698 -- 57,377,516(+) GCAGA(C/T)GTGCA intron-variant
rs1000208804 -- 57,369,328(+) CTGTG(C/T)AGCAA intron-variant
rs1000286074 -- 57,356,907(+) AGGGG(A/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAE1 Gene

Variant ID Type Subtype PubMed ID
nsv1055983 CNV gain 25217958
nsv3424 CNV insertion 18451855
nsv459027 CNV loss 19166990
nsv586311 CNV loss 21841781
nsv965892 CNV duplication 23825009

Variation tolerance for RAE1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAE1 Gene

Disorders for RAE1 Gene

Relevant External Links for RAE1

Human Genome Epidemiology (HuGE) Navigator
RAE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAE1

No disorders were found for RAE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAE1 Gene

Publications for RAE1 Gene

  1. The human RAE1 gene is a functional homologue of Schizosaccharomyces pombe rae1 gene involved in nuclear export of Poly(A)+ RNA. (PMID: 9370289) Bharathi A … Dhar R (Gene 1997) 2 3 4 22 60
  2. mRNA binding protein mrnp 41 localizes to both nucleus and cytoplasm. (PMID: 9256445) Kraemer D … Blobel G (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 60
  3. RAE-1, a novel PHR binding protein, is required for axon termination and synapse formation in Caenorhabditis elegans. (PMID: 22357847) Grill B … Garner CC (The Journal of neuroscience : the official journal of the Society for Neuroscience 2012) 3 4 60
  4. Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1. (PMID: 20498086) Ren Y … Hoelz A (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 4 60
  5. Rae1 interaction with NuMA is required for bipolar spindle formation. (PMID: 17172455) Wong RW … Coutavas E (Proceedings of the National Academy of Sciences of the United States of America 2006) 3 4 60

Products for RAE1 Gene

Sources for RAE1 Gene

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