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Aliases for RADIL Gene

Aliases for RADIL Gene

  • Rap Associating With DIL Domain 2 3
  • Ras Association And DIL Domains 2 3 5
  • Rap GTPase Interactor 3
  • KIAA1849 4
  • RASIP2 3

External Ids for RADIL Gene

Previous GeneCards Identifiers for RADIL Gene

  • GC07M004804
  • GC07M004836
  • GC07M004755

Summaries for RADIL Gene

GeneCards Summary for RADIL Gene

RADIL (Rap Associating With DIL Domain) is a Protein Coding gene. An important paralog of this gene is RASIP1.

UniProtKB/Swiss-Prot for RADIL Gene

  • Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.

Gene Wiki entry for RADIL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RADIL Gene

Genomics for RADIL Gene

Regulatory Elements for RADIL Gene

Enhancers for RADIL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RADIL on UCSC Golden Path with GeneCards custom track

Promoters for RADIL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RADIL on UCSC Golden Path with GeneCards custom track

Genomic Location for RADIL Gene

Chromosome:
7
Start:
4,797,055 bp from pter
End:
4,883,719 bp from pter
Size:
86,665 bases
Orientation:
Minus strand

Genomic View for RADIL Gene

Genes around RADIL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RADIL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RADIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RADIL Gene

Proteins for RADIL Gene

  • Protein details for RADIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JH8-RADIL_HUMAN
    Recommended name:
    Ras-associating and dilute domain-containing protein
    Protein Accession:
    Q96JH8
    Secondary Accessions:
    • A4D1Z5
    • A5YM49
    • B7ZL20
    • Q0VFZ9
    • Q75LH3
    • Q9BSP5
    • Q9H0M6
    • Q9NW43
    • Q9NWC4

    Protein attributes for RADIL Gene

    Size:
    1075 amino acids
    Molecular mass:
    117455 Da
    Quaternary structure:
    • Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).
    SequenceCaution:
    • Sequence=AAS07559.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91543.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47478.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RADIL Gene

    Alternative splice isoforms for RADIL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RADIL Gene

Proteomics data for RADIL Gene at MOPED

Post-translational modifications for RADIL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RADIL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RADIL Gene

Domains & Families for RADIL Gene

Gene Families for RADIL Gene

Suggested Antigen Peptide Sequences for RADIL Gene

Graphical View of Domain Structure for InterPro Entry

Q96JH8

UniProtKB/Swiss-Prot:

RADIL_HUMAN :
  • Contains 1 dilute domain.
  • Belongs to the RADIL family.
Domain:
  • Contains 1 dilute domain.
  • Contains 1 FHA domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 Ras-associating domain.
Family:
  • Belongs to the RADIL family.
genes like me logo Genes that share domains with RADIL: view

Function for RADIL Gene

Molecular function for RADIL Gene

UniProtKB/Swiss-Prot Function:
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.
genes like me logo Genes that share phenotypes with RADIL: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RADIL Gene

Localization for RADIL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RADIL Gene COMPARTMENTS Subcellular localization image for RADIL gene
Compartment Confidence
cytoskeleton 5
cytosol 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RADIL Gene

Pathways & Interactions for RADIL Gene

SuperPathways for RADIL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RADIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0034446 substrate adhesion-dependent cell spreading IDA 23209302
genes like me logo Genes that share ontologies with RADIL: view

No data available for Pathways by source and SIGNOR curated interactions for RADIL Gene

Drugs & Compounds for RADIL Gene

No Compound Related Data Available

Transcripts for RADIL Gene

Unigene Clusters for RADIL Gene

Ras association and DIL domains:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RADIL Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10: - -

ExUns: 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for RADIL Gene

GeneLoc Exon Structure for
RADIL
ECgene alternative splicing isoforms for
RADIL

Expression for RADIL Gene

mRNA expression in normal human tissues for RADIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for RADIL Gene Hs.667336

genes like me logo Genes that share expression patterns with RADIL: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RADIL Gene

Orthologs for RADIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RADIL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RADIL 35
  • 82.99 (n)
  • 80.39 (a)
RADIL 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RADIL 35
  • 84.56 (n)
  • 83.55 (a)
RADIL 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Radil 35
  • 80.74 (n)
  • 81.61 (a)
Radil 16
Radil 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RADIL 35
  • 98.73 (n)
  • 98.51 (a)
RADIL 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Radil 35
  • 81.16 (n)
  • 81.82 (a)
oppossum
(Monodelphis domestica)
Mammalia RADIL 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RADIL 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves RADIL 35
  • 68.94 (n)
  • 62.85 (a)
RADIL 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RADIL 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii radil 35
  • 58.01 (n)
  • 53.68 (a)
radil 36
  • 43 (a)
OneToMany
radil 36
  • 58 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for RADIL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RADIL Gene

ENSEMBL:
Gene Tree for RADIL (if available)
TreeFam:
Gene Tree for RADIL (if available)

Paralogs for RADIL Gene

Paralogs for RADIL Gene

(5) SIMAP similar genes for RADIL Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RADIL: view

Variants for RADIL Gene

Sequence variations from dbSNP and Humsavar for RADIL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs414035 - 4,801,839(-) AACCC(A/G)GCCGT reference, missense
rs3763384 - 4,836,426(-) GCCCC(A/G)ACGCC reference, missense
rs2292498 - 4,834,789(-) AGCCC(A/C/G)ACCTG reference, missense
rs6966329 - 4,801,682(+) CGCTG(A/G)GTCCG reference, missense
rs879217 -- 4,821,204(+) AAGCC(A/G)GACCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RADIL Gene

Variant ID Type Subtype PubMed ID
nsv887377 CNV Loss 21882294
dgv7134n71 CNV Loss 21882294
nsv471293 CNV Loss 18288195
dgv7135n71 CNV Loss 21882294
nsv823994 CNV Gain 20364138
nsv8033 CNV Loss 18304495
esv2664593 CNV Deletion 23128226
dgv7136n71 CNV Loss 21882294
dgv7137n71 CNV Loss 21882294
nsv528748 CNV Loss 19592680
nsv887388 CNV Loss 21882294
nsv5626 CNV Insertion 18451855
esv28123 CNV Loss 19812545
esv2733904 CNV Deletion 23290073

Variation tolerance for RADIL Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.88; 91.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RADIL Gene

Human Gene Mutation Database (HGMD)
RADIL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RADIL Gene

Disorders for RADIL Gene

Relevant External Links for RADIL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RADIL

No disorders were found for RADIL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RADIL Gene

Publications for RADIL Gene

  1. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. (PMID: 17704304) Smolen G.A. … Haber D.A. (Genes Dev. 2007) 2 3 4 67
  2. AF6 negatively regulates Rap1-induced cell adhesion. (PMID: 16051602) Zhang Z. … Bos J.L. (J. Biol. Chem. 2005) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for RADIL Gene

Sources for RADIL Gene

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