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RADIL Gene

protein-coding   GIFtS: 49
GCID: GC07M004836

Ras Association And DIL Domains

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ras Association And DIL Domains1 2
KIAA18493 5
RASIP22
Rap GTPase Interactor2
Ras-Associating And Dilute Domain-Containing Protein2

External Ids:    HGNC: 222261   Entrez Gene: 556982   Ensembl: ENSG000001579277   OMIM: 6114915   UniProtKB: Q96JH83   

Export aliases for RADIL gene to outside databases

Previous GC identifers: GC07M004804 GC07M004755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RADIL Gene:
RADIL (Ras association and DIL domains) is a protein-coding gene. Diseases associated with RADIL include keratoconus, and myopia. An important paralog of this gene is RASIP1.

UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8
Function: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during
development

Gene Wiki entry for RADIL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the RADIL gene promoter:
         Sp1   MAZR   AP-1   ATF-2   MyoD   MIF-1   CUTL1   C/EBPalpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RADIL promoter sequence
   Search Chromatin IP Primers for RADIL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RADIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

RADIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RADIL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M004836:  view genomic region     (about GC identifiers)

Start:
4,836,686 bp from pter      End:
4,923,350 bp from pter
Size:
86,665 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 4,885,095-4,969,690     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8 (See protein sequence)
Recommended Name: Ras-associating and dilute domain-containing protein  
Size: 1075 amino acids; 117455 Da
Subunit: Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family
Sequence caution: Sequence=AAS07559.1; Type=Erroneous gene model prediction; Sequence=BAA91543.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB47478.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RADIL:
1UM1 (3D)        3EC8 (3D)    
Secondary accessions: A4D1Z5 A5YM49 B7ZL20 Q0VFZ9 Q75LH3 Q9BSP5 Q9H0M6 Q9NW43 Q9NWC4
Alternative splicing: 4 isoforms:  Q96JH8-4   Q96JH8-2   Q96JH8-3   Q96JH8-1   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RADIL: NX_Q96JH8

Explore proteomics data for RADIL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RADIL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060529.4  
    ENSEMBL proteins: 
     ENSP00000413403   ENSP00000382492   ENSP00000398057   ENSP00000442966   ENSP00000442533  

    RADIL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for RADIL

    RADIL Antibody Products:

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    Search LSBio for Antibodies for RADIL

    RADIL Assay Products:

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    Cloud-Clone Corp. CLIAs for RADIL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR008984 SMAD_FHA_domain
     IPR018444 Dil_domain
     IPR002710 Dilute
     IPR000159 Ras-assoc
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96JH8

    ProtoNet protein and cluster: Q96JH8

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000253 Forkhead-associated (FHA)
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8
    Similarity: Belongs to the RADIL family
    Similarity: Contains 1 dilute domain
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 Ras-associating domain


    RADIL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RADIL_HUMAN, Q96JH8
    Function: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during
    development

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RADIL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RADIL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RADIL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RADIL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RADIL

    miRNA
    Products:
        
    miRTarBase miRNAs that target RADIL:
    hsa-mir-615-3p (MIRT040348), hsa-mir-192-5p (MIRT026743), hsa-mir-215-5p (MIRT024802)

    Block miRNA regulation of human, mouse, rat RADIL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RADIL:
    hsa-miR-136 hsa-miR-495
    SwitchGear 3'UTR luciferase reporter plasmidRADIL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RADIL
    Predesigned siRNA for gene silencing in human, mouse, rat RADIL

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for RADIL

    Clone
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    GenScript: all cDNA clones in your preferred vector: RADIL (NM_018059)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RADIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RADIL

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RADIL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RADIL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule IDA--

    RADIL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RADIL
    Interactions:

        Search GeneGlobe Interaction Network for RADIL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RADIL (Q96JH81, 2, 3 ENSP000003824924) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66865 I2D: score=5 STRING: ENSP00000360441
    MED19A0JLT22, 3, ENSP000003373404STRING: ENSP00000337340 MINT-64897 I2D: score=4 
    CDK2P249411, 3, ENSP000002669704EBI-744267,EBI-375096 I2D: score=2 STRING: ENSP00000266970
    ASCC2Q9H1I82, 3MINT-65473 I2D: score=4 
    LITAFQ997322, 3MINT-65289 I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007165signal transduction IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0034446substrate adhesion-dependent cell spreading IDA--

    RADIL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RADIL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for RADIL gene: 
    NM_018059.4  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445392(uc003sng.1 uc003snh.1 uc003sni.1 uc011jwc.1 uc003snj.1 uc011jwd.1)
    ENST00000472999 ENST00000399583 ENST00000473130 ENST00000469399 ENST00000484211
    ENST00000457174 ENST00000538469 ENST00000536091
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RADIL using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RADIL:
    hsa-miR-136 hsa-miR-495
    SwitchGear 3'UTR luciferase reporter plasmidRADIL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RADIL
    Predesigned siRNA for gene silencing in human, mouse, rat RADIL
    Clone
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    OriGene clones in human, mouse for RADIL (see all 8)
    OriGene ORF clones in mouse, rat for RADIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RADIL (NM_018059)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RADIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RADIL
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RADIL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RADIL
      QuantiTect SYBR Green Assays in human, mouse, rat RADIL
      QuantiFast Probe-based Assays in human, mouse, rat RADIL

    Selected AceView cDNA sequences (see all 72):

    BM725350 AK000997 AI076876 BF114928 CR598494 AL044980 AB058752 BQ070639 
    AW296772 BM799509 AK001186 NM_018059 BI667728 AL535725 BM473518 BQ232134 
    BQ422998 BE728860 BC048346 BX415125 BE276824 BE885462 BF448533 AU118216 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RADIL (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RADIL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RADIL expression in normal human tissues (normalized intensities)      RADIL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTCAGTG
    RADIL Expression
    About this image


    RADIL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             Mature Rod Cells Outer Nuclear Layer
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)
    RADIL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RADIL Protein Expression
        Custom PCR Arrays for RADIL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RADIL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RADIL gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Radil1 , 5 Ras association and DIL domains1, 5 80.74(n)1
    81.61(a)1
      5 (81.53 cM)5
    2318581  NM_178702.31  NP_848817.21 
     1424848395 
    chicken
    (Gallus gallus)
    Aves RADIL1 Ras association and DIL domains 68.94(n)
    62.85(a)
      416479  XM_004945146.1  XP_004945203.1 
    lizard
    (Anolis carolinensis)
    Reptilia RADIL6
    Ras association and DIL domains
    54(a)
    1 ↔ 1
    GL343591.1(180348-225973)
    zebrafish
    (Danio rerio)
    Actinopterygii radil1 Rap GTPase interactor 58.01(n)
    53.68(a)
      562363  NM_001102569.1  NP_001096039.1 
    rice
    (Oryza sativa)
    Liliopsida AK068880.12   -- 73.37(n)    AK068880.1 


    ENSEMBL Gene Tree for RADIL (if available)
    TreeFam Gene Tree for RADIL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RADIL gene
    RASIP12  
    5 SIMAP similar genes for RADIL using alignment to 5 protein entries:     RADIL_HUMAN (see all proteins):
    FLJ10324    DLG4    RASIP1    TJP2    FRMPD2

    RADIL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RADIL (see all 2490)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799591071,2
    C,F--4838301(+) GGGCCG/ACCAGC 1 -- int13Minor allele frequency- A:0.08CSA WA NA 240
    rs784791251,2
    C,F--4838347(+) GAGAGG/TAACTC 1 -- int11Minor allele frequency- T:0.07NA 120
    rs733073121,2
    C,F--4838365(+) AGCAGG/TAGTCC 1 -- int12Minor allele frequency- T:0.15WA 120
    rs778729001,2
    C,F--4838381(+) GAGGAA/GGCAGG 1 -- int15Minor allele frequency- G:0.15WA CSA NA EA 362
    rs1175829941,2
    F--4838419(+) ACCATC/GAGGCC 1 -- int11Minor allele frequency- G:0.03EA 120
    rs777693191,2
    C,F--4838438(+) TTCCAA/GCGCCT 1 -- int11Minor allele frequency- G:0.02EA 120
    rs733073131,2
    C,F--4838440(+) CCAACG/ACCTGG 1 -- int12Minor allele frequency- A:0.15WA 120
    rs1452542841,2
    C--4838454(+) TCTAGA/CCCTTT 1 -- int10--------
    rs733073141,2
    C--4838476(+) GTGCTG/AAGCAG 1 -- int13Minor allele frequency- A:0.08WA NA 240
    rs733073151,2
    C--4838582(+) GGGACG/AGGGGC 1 -- int12Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for RADIL (4836686 - 4923350 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RADIL (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664593CNV Deletion23128226
    esv2733904CNV Deletion23290073
    nsv5626CNV Insertion18451855
    dgv7136n71CNV Loss21882294
    esv28123CNV Loss19812545
    nsv887377CNV Loss21882294
    dgv7134n71CNV Loss21882294
    nsv471293CNV Loss18288195
    nsv887388CNV Loss21882294
    dgv7135n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RADIL
    DNA2.0 Custom Variant and Variant Library Synthesis for RADIL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611491    OMIM disorders: --

    5 diseases for RADIL:    About MalaCards
    keratoconus    myopia    ataxia    obesity
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RADIL:
    Keratoconus

    RADIL for disorders           About GeneDecksing


    Export disorders for RADIL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RADIL gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with RADIL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. (PubMed id 17704304)1, 2, 3 Smolen G.A.... Haber D.A. (Genes Dev. 2007)
    2. AF6 negatively regulates Rap1-induced cell adhesion. (PubMed id 16051602)1, 3 Zhang Z....Bos J.L. (J. Biol. Chem. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    8. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. (PubMed id 23209302)1 Ahmed S.M....Angers S. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55698 HGNC: 22226 AceView: FLJ10324 Ensembl:ENSG00000157927 euGenes: HUgn55698
    ECgene: RADIL H-InvDB: RADIL

    (According to HUGE)
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    HUGE: KIAA1849

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RADIL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RADIL gene:
    Search GeneIP for patents involving RADIL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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