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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RADIL Gene

protein-coding   GIFtS: 52
GCID: GC07M004836

Ras Association And DIL Domains

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ras Association And DIL Domains1 2
KIAA18493 5
RASIP22
Rap GTPase Interactor2
Ras-Associating And Dilute Domain-Containing Protein2

External Ids:    HGNC: 222261   Entrez Gene: 556982   Ensembl: ENSG000001579277   OMIM: 6114915   UniProtKB: Q96JH83   

Export aliases for RADIL gene to outside databases

Previous GC identifers: GC07M004804 GC07M004755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for RADIL Gene: 
RADIL (Ras association and DIL domains) is a protein-coding gene. Diseases associated with RADIL include keratoconus, and myopia. An important paralog of this gene is RASIP1.

UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8
Function: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during
development

Gene Wiki entry for RADIL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RADIL gene promoter:
         Sp1   MAZR   AP-1   ATF-2   MyoD   MIF-1   CUTL1   C/EBPalpha   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RADIL promoter sequence
   Search SABiosciences Chromatin IP Primers for RADIL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RADIL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

RADIL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RADIL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M004836:  view genomic region     (about GC identifiers)

Start:
4,836,686 bp from pter      End:
4,923,350 bp from pter
Size:
86,665 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 4,885,095-4,969,690     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8 (See protein sequence)
Recommended Name: Ras-associating and dilute domain-containing protein  
Size: 1075 amino acids; 117455 Da
Subunit: Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family
Sequence caution: Sequence=AAS07559.1; Type=Erroneous gene model prediction; Sequence=BAA91543.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB47478.1; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
2 PDB 3D structures from and Proteopedia for RADIL:
1UM1 (3D)        3EC8 (3D)    
Secondary accessions: A4D1Z5 A5YM49 B7ZL20 Q0VFZ9 Q75LH3 Q9BSP5 Q9H0M6 Q9NW43 Q9NWC4
Alternative splicing: 4 isoforms:  Q96JH8-4   Q96JH8-2   Q96JH8-3   Q96JH8-1   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RADIL: NX_Q96JH8

Explore proteomics data for RADIL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96JH8

  • RADIL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RADIL Protein Expression
    REFSEQ proteins: NP_060529.4  
    ENSEMBL proteins: 
     ENSP00000413403   ENSP00000382492   ENSP00000398057   ENSP00000442966   ENSP00000442533  

    Human Recombinant Protein Products for RADIL: 
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for RADIL
    GenScript Custom Purified and Recombinant Proteins Services for RADIL
    Novus Biologicals RADIL Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RADIL 


    RADIL Antibody Products: 
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    Abcam antibodies for RADIL
    Cloud-Clone Corp. Antibodies for RADIL 
    ThermoFisher Antibody for RADIL
    LSBio Antibodies in human, mouse, rat for RADIL 

    Assay Products for RADIL: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RADIL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RADIL 
    Cloud-Clone Corp. CLIAs for RADIL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR008984 SMAD_FHA_domain
     IPR018444 Dil_domain
     IPR002710 Dilute
     IPR000159 Ras-assoc
     IPR001478 PDZ

    Graphical View of Domain Structure for InterPro Entry Q96JH8

    ProtoNet protein and cluster: Q96JH8

    3 Blocks protein domains:
    IPB000159 RA domain
    IPB000253 Forkhead-associated (FHA)
    IPB001478 PDZ/DHR/GLGF domain


    UniProtKB/Swiss-Prot: RADIL_HUMAN, Q96JH8
    Similarity: Belongs to the RADIL family
    Similarity: Contains 1 dilute domain
    Similarity: Contains 1 FHA domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 Ras-associating domain


    RADIL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RADIL_HUMAN, Q96JH8
    Function: Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during
    development

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    RADIL for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RADIL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RADIL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RADIL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RADIL 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RADIL
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RADIL:
    hsa-miR-136 hsa-miR-495
    SwitchGear 3'UTR luciferase reporter plasmidRADIL 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RADIL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RADIL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RADIL
    Sirion Biotech Customized adenovirus for overexpression of RADIL

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for RADIL (see all 6)
    OriGene ORF clones in mouse, rat for RADIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RADIL (NM_018059)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RADIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RADIL
    Sirion Biotech Customized lentivirus for stable overexpression of RADIL 
                         Customized lentivirus expression plasmids for stable overexpression of RADIL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for RADIL
    Search LifeMap BioReagents cell lines for RADIL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RADIL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RADIL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/27 Interacting proteins for RADIL (Q96JH81, 2, 3 ENSP000003824924) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOXF2Q9BQY42, 3, ENSP000003604414MINT-66865 I2D: score=5 STRING: ENSP00000360441
    MED19A0JLT22, 3, ENSP000003373404STRING: ENSP00000337340 MINT-64897 I2D: score=4 
    CDK2P249411, 3, ENSP000002669704EBI-744267,EBI-375096 I2D: score=2 STRING: ENSP00000266970
    ASCC2Q9H1I82, 3MINT-65473 I2D: score=4 
    LITAFQ997322, 3MINT-65289 I2D: score=3 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction IEA--
    GO:0007275multicellular organismal development IEA--

    RADIL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RADIL

    Search CenterWatch for drugs/clinical trials and news about RADIL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RADIL gene: 
    NM_018059.4  

    Unigene Cluster for RADIL:

    Ras association and DIL domains
    Hs.667336  [show with all ESTs]
    Unigene Representative Sequence: NM_018059
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000445392(uc003sng.1 uc003snh.1 uc003sni.1 uc011jwc.1 uc003snj.1 uc011jwd.1)
    ENST00000472999 ENST00000399583 ENST00000473130 ENST00000469399 ENST00000484211
    ENST00000457174 ENST00000538469 ENST00000536091
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RADIL
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate RADIL:
    hsa-miR-136 hsa-miR-495
    SwitchGear 3'UTR luciferase reporter plasmidRADIL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for RADIL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RADIL
    Clone
    Products:
         
    OriGene clones in human, mouse for RADIL (see all 6)
    OriGene ORF clones in mouse, rat for RADIL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RADIL (NM_018059)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RADIL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RADIL
    Sirion Biotech Customized lentivirus for stable overexpression of RADIL 
                         Customized lentivirus expression plasmids for stable overexpression of RADIL 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RADIL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RADIL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RADIL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RADIL

    Additional mRNA sequence: 

    AK000997.1 AK001186.1 AK294745.1 AK296325.1 AK302549.1 AL136731.1 BC004919.2 BC117317.1 
    BC126311.1 BC143526.1 EF560723.1 

    10 DOTS entries:

    DT.75121763  DT.121038453  DT.91744549  DT.65286966  DT.97802978  DT.97838575  DT.121038444  DT.91966600 
    DT.95095224  DT.316476 

    24/72 AceView cDNA sequences (see all 72):

    BF114928 CR598494 AL044980 AB058752 BQ070639 AW296772 BM799509 AK001186 
    NM_018059 BM725350 AK000997 AI076876 AK094524 BQ232134 BE276824 BE885462 
    BF448533 AU118216 AI041242 BX431000 AL136731 BQ889832 CK001190 AI694314 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RADIL (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                    -                                       
    SP4:                                                                                                                    -                                       
    SP5:                                                                                                                                                            

    ExUns: 17
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for RADIL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RADIL expression in normal human tissues (normalized intensities)      RADIL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTCAGTG
    RADIL Expression
    About this image


    RADIL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Eye (Sensory Organs)
             Mature Rod Cells Outer Nuclear Layer
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)

    See RADIL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RADIL

    SOURCE GeneReport for Unigene cluster: Hs.667336
        SABiosciences Custom PCR Arrays for RADIL
    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RADIL
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RADIL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RADIL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RADIL gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Radil1 , 5 Ras association and DIL domains1, 5 80.88(n)1
    81.78(a)1
      5 (81.53 cM)5
    2318581  NM_178702.31  NP_848817.21 
     1424848395 
    chicken
    (Gallus gallus)
    Aves RADIL1 Ras association and DIL domains 71.38(n)
    65.9(a)
      416479  XM_003642143.1  XP_003642191.1 
    lizard
    (Anolis carolinensis)
    Reptilia RADIL6
    Ras association and DIL domains
    55(a)
    1 ↔ 1
    GL343591.1(180348-225973)
    zebrafish
    (Danio rerio)
    Actinopterygii radil1 Rap GTPase interactor 58.14(n)
    53.93(a)
      562363  NM_001102569.1  NP_001096039.1 
    rice
    (Oryza sativa)
    Liliopsida AK068880.12   -- 73.37(n)    AK068880.1 


    ENSEMBL Gene Tree for RADIL (if available)
    TreeFam Gene Tree for RADIL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RADIL gene
    RASIP12  
    5 SIMAP similar genes for RADIL using alignment to 5 protein entries:     RADIL_HUMAN (see all proteins):
    FLJ10324    DLG4    RASIP1    TJP2    FRMPD2

    RADIL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2490 SNPs in RADIL are shown (see all 2490)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs799591071,2
    C,F--4838301(+) GGGCCG/ACCAGC 1 -- int13Minor allele frequency- A:0.08CSA WA NA 240
    rs784791251,2
    C,F--4838347(+) GAGAGG/TAACTC 1 -- int11Minor allele frequency- T:0.07NA 120
    rs733073121,2
    C,F--4838365(+) AGCAGG/TAGTCC 1 -- int12Minor allele frequency- T:0.15WA 120
    rs778729001,2
    C,F--4838381(+) GAGGAA/GGCAGG 1 -- int15Minor allele frequency- G:0.15WA CSA NA EA 362
    rs1175829941,2
    F--4838419(+) ACCATC/GAGGCC 1 -- int11Minor allele frequency- G:0.03EA 120
    rs777693191,2
    C,F--4838438(+) TTCCAA/GCGCCT 1 -- int11Minor allele frequency- G:0.02EA 120
    rs733073131,2
    C,F--4838440(+) CCAACG/ACCTGG 1 -- int12Minor allele frequency- A:0.15WA 120
    rs1452542841,2
    C--4838454(+) TCTAGA/CCCTTT 1 -- int10--------
    rs733073141,2
    C--4838476(+) GTGCTG/AAGCAG 1 -- int13Minor allele frequency- A:0.08WA NA 240
    rs733073151,2
    C--4838582(+) GGGACG/AGGGGC 1 -- int12Minor allele frequency- A:0.11WA 120

    HapMap Linkage Disequilibrium report for RADIL (4836686 - 4923350 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for RADIL (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664593CNV Deletion23128226
    esv2733904CNV Deletion23290073
    nsv5626CNV Insertion18451855
    dgv7136n71CNV Loss21882294
    esv28123CNV Loss19812545
    nsv887377CNV Loss21882294
    dgv7134n71CNV Loss21882294
    nsv471293CNV Loss18288195
    nsv887388CNV Loss21882294
    dgv7135n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RADIL
    DNA2.0 Custom Variant and Variant Library Synthesis for RADIL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611491    OMIM disorders: --

    3 diseases for RADIL:    About MalaCards
    keratoconus    myopia    breast cancer

    1 disease from the University of Copenhagen DISEASES database for RADIL:
    Keratoconus

    RADIL for disorders           About GeneDecksing


    Export disorders for RADIL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RADIL gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with RADIL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. (PubMed id 17704304)1, 2, 3 Smolen G.A.... Haber D.A. (2007)
    2. AF6 negatively regulates Rap1-induced cell adhesion. (PubMed id 16051602)1, 3 Zhang Z....Bos J.L. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
    7. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    8. KIF14 negatively regulates Rap1a-Radil signaling durin g breast cancer progression. (PubMed id 23209302)1 Ahmed S.M....Angers S. (2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    10. Radil controls neutrophil adhesion and motility throug h b2-integrin activation. (PubMed id 23097489)1 Liu L....Parent C.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55698 HGNC: 22226 AceView: FLJ10324 Ensembl:ENSG00000157927 euGenes: HUgn55698
    ECgene: RADIL H-InvDB: RADIL

    (According to HUGE)
    About This Section
    HUGE: KIAA1849

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RADIL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RADIL gene:
    Search GeneIP for patents involving RADIL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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