RAD9B Gene
protein-coding GIFtS: 50
GCID: GC12P110939
|
|
RAD9 homolog B (S. pombe)
| |
Aliases
for RAD9B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAD9 Homolog B (S. Pombe)1 2 | | DNA Repair Exonuclease Rad9 Homolog B2 3 | | HRAD9B1 | | FLJ403461 | | Cell Cycle Checkpoint Control Protein RAD9B2 | | Cell Cycle Checkpoint Control Protein RAD9B Homolog2 |
Export aliases for RAD9B gene to outside databasesPrevious GC identifers: GC12P110782 GC12P109351 GC12P109402 GC12P107958 |
Summaries
for RAD9B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for RAD9B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAD9B gene promoter:
GR Pax-2 HSF1 (long) Pax-2a C/EBPalpha Evi-1 Egr-2 S8 HSF1short GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAD9B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD9B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.13RAD9B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P110939: view genomic region
(about GC identifiers)
Start:
|
110,939,460 bp from pter |
End:
|
110,969,891 bp from pter |
Size:
|
30,432 bases |
Orientation:
|
plus strand |
|
Proteins
for RAD9B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAD9B_HUMAN, Q6WBX8 (See
protein sequence)Recommended Name: Cell cycle checkpoint control protein RAD9B Size: 426 amino acids; 47832 Da
Subunit: Interacts with HUS1, HUS1B, RAD1, RAD9A and RAD17
Secondary accessions: Q5U5K0 Q6NVJ1 Q6ZVT7 Q8N7T9 Q96LI8Alternative splicing: 5 isoforms: Q6WBX8-5 Q6WBX8-1 Q6WBX8-2 Q6WBX8-3 Q6WBX8-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for RAD9B: NX_Q6WBX8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6WBX8
RAD9B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689655.3
ENSEMBL proteins: ENSP00000387329 ENSP00000376440 ENSP00000386434 ENSP00000386629 ENSP00000386697 ENSP00000350777 ENSP00000388271 Reactome Protein details: Q6WBX8
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005654 | nucleoplasm |
TAS | -- | | GO:0030896 | checkpoint clamp complex |
IEA | -- |
RAD9B for ontologies About GeneDecksing
RAD9B Antibody Products:
Assay Products for RAD9B: |
Protein
Domains /
Families
for RAD9B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAD9B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6WBX8ProtoNet protein and cluster: Q6WBX8 UniProtKB/Swiss-Prot: RAD9B_HUMAN, Q6WBX8Similarity: Belongs to the rad9 family |
Function
for RAD9B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAD9B (NM_152442) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD9B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
RAD9B for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RAD9B:
Animal Models:
Mouse knock-out Rad9btm1Lieb for RAD9B
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rad9b):
RAD9B for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAD9B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Activation of ATR in response to replication stress | | | 2 | DNA damage ATM/ATR regulation of G1/S checkpoint | | | 3 | Transcription_Androgen Receptor nuclear signaling | | | 4 | Cell Cycle | | | 5 | Meiosis | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for RAD9B
2  GeneGo (Thomson Reuters) Pathways for RAD9B
4 
Reactome Pathways for RAD9B
RAD9B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD9B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 13)
5/13 Interacting proteins for RAD9B (Q6WBX83 ENSP000003764404) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
RAD9B for ontologies About GeneDecksing
|
Drugs & Compounds
for RAD9B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for RAD9B
Search CenterWatch for drugs/clinical trials and news about RAD9B
|
Transcripts
for RAD9B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAD9B gene: NM_152442.3 Unigene Cluster for RAD9B: RAD9 homolog B (S. pombe) Hs.97794 [show with all ESTs]Unigene Representative Sequence: BC0476459 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433301 ENST00000409246(uc001trf.4 uc001trg.4 uc010sya.2)
ENST00000392672 ENST00000409300 ENST00000409425(uc001tre.4) ENST00000409778
ENST00000409461 ENST00000358071(uc001trd.4) ENST00000447044
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAD9B (NM_152442) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD9B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9B |
Additional cDNA sequence: AK056139.1 AK058176.1 AK097665.1 AK124109.1 AK301826.1 AK302512.1 AY297459.1 BC037353.1 BC047645.1 BC064974.1 BC068031.1 10 DOTS entries: DT.97774636 DT.99998055 DT.100685960 DT.91830394 DT.205415 DT.436246 DT.97778071 DT.121216149 DT.97792540 DT.99945339 24 AceView cDNA sequences: BC068031 AY297459 BX094118 AK097665 CB127251 BC047645 AK124109 AA412179 AK056139 BX280464 NM_152442 BI459646 BC037353 AA399017 AA970946 CD511820 BC064974 BG718006 CD244296 BP371414 AK058176 BU193721 AA400412 AA400411
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for RAD9B About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13 |
|---|
|
| SP1: | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAD9B
|
Expression
for RAD9B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAD9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTTTTTG
About this image
See RAD9B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAD9B
SOURCE GeneReport for Unigene cluster: Hs.97794
UniProtKB/Swiss-Prot: RAD9B_HUMAN, Q6WBX8Tissue specificity: Expressed in testis and skeletal muscle
SABiosciences Custom PCR Arrays for RAD9B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD9B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAD9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD9B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9B |
Orthologs
for RAD9B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAD9B gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for RAD9B (if available)
TreeFam Gene Tree for RAD9B (if available) |
Paralogs
for RAD9B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAD9B gene
- RAD9A2
1 SIMAP similar gene for RAD9B using alignment to 6 protein entries: RAD9B_HUMAN (see all proteins):RAD9A
RAD9B for paralogs About GeneDecksing
|
Genomic Variants
for RAD9B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAD9B (110939460 - 110969891 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for RAD9B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD9B |
|
Disorders
/ Diseases
for RAD9B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 RAD9B for disorders About MalaCards
RAD9B for disorders About GeneDecksing
OMIM gene information: 608368
OMIM disorders: --
Export disorders for RAD9B gene to outside databases
|
Publications
for RAD9B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAD9B gene integrated from 9 sources:
(articles sorted by number of sources associating them with RAD9B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene. (PubMed id 14611806)1, 2 Dufault V.M.... Karnitz L.M. (2003)
- Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PubMed id 14500360)1, 2 Hopkins K.M....Lieberman H.B. (2003)
- Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition. (PubMed id 22399810)1 Perez-Castro A.J. and Freire R. (2012)
- Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. (PubMed id 16365875)1 Lieberman H.B. (2006)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. (PubMed id 12791985)1 Zou L. and Elledge S.J. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for RAD9B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAD9B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAD9B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RAD9B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for RAD9B gene:
Search GeneIP for patents involving RAD9B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for RAD9B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for RAD9B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD9B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD9B | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAD9B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAD9B | | OriGene Custom Protein Services for RAD9B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAD9B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD9B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD9B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD9B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD9B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD9B |
| |
 |  |  |  | |
| | | | Search Tocris compounds for RAD9B |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | RAD9B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9B |
|  |  |  | | | | Search ThermoFisher Antibodies for RAD9B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9B |
|
|
|
|
