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Aliases for RAD9B Gene

Aliases for RAD9B Gene

  • RAD9 Checkpoint Clamp Component B 2 3 5
  • DNA Repair Exonuclease Rad9 Homolog B 4
  • RAD9 Homolog B (S. Pombe) 2
  • HRAD9B 4

External Ids for RAD9B Gene

Previous GeneCards Identifiers for RAD9B Gene

  • GC12P110782
  • GC12P109351
  • GC12P109402
  • GC12P110939
  • GC12P107958

Summaries for RAD9B Gene

GeneCards Summary for RAD9B Gene

RAD9B (RAD9 Checkpoint Clamp Component B) is a Protein Coding gene. Among its related pathways are Gene Expression and Cell Cycle, Mitotic. An important paralog of this gene is RAD9A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD9B Gene

Genomics for RAD9B Gene

Regulatory Elements for RAD9B Gene

Promoters for RAD9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAD9B on UCSC Golden Path with GeneCards custom track

Genomic Location for RAD9B Gene

Chromosome:
12
Start:
110,501,655 bp from pter
End:
110,532,086 bp from pter
Size:
30,432 bases
Orientation:
Plus strand

Genomic View for RAD9B Gene

Genes around RAD9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD9B Gene

Proteins for RAD9B Gene

  • Protein details for RAD9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6WBX8-RAD9B_HUMAN
    Recommended name:
    Cell cycle checkpoint control protein RAD9B
    Protein Accession:
    Q6WBX8
    Secondary Accessions:
    • Q5U5K0
    • Q6NVJ1
    • Q6ZVT7
    • Q8N7T9
    • Q96LI8

    Protein attributes for RAD9B Gene

    Size:
    426 amino acids
    Molecular mass:
    47832 Da
    Quaternary structure:
    • Interacts with HUS1, HUS1B, RAD1, RAD9A and RAD17.

    Alternative splice isoforms for RAD9B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD9B Gene

Proteomics data for RAD9B Gene at MOPED

Post-translational modifications for RAD9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD9B Gene

Domains & Families for RAD9B Gene

Protein Domains for RAD9B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6WBX8

UniProtKB/Swiss-Prot:

RAD9B_HUMAN :
  • Belongs to the rad9 family.
Family:
  • Belongs to the rad9 family.
genes like me logo Genes that share domains with RAD9B: view

No data available for Gene Families for RAD9B Gene

Function for RAD9B Gene

genes like me logo Genes that share phenotypes with RAD9B: view

Animal Models for RAD9B Gene

MGI Knock Outs for RAD9B:

Animal Model Products

miRNA for RAD9B Gene

miRTarBase miRNAs that target RAD9B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD9B Gene

Localization for RAD9B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD9B Gene COMPARTMENTS Subcellular localization image for RAD9B gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RAD9B Gene

Pathways & Interactions for RAD9B Gene

genes like me logo Genes that share pathways with RAD9B: view

Gene Ontology (GO) - Biological Process for RAD9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint IBA --
GO:0000077 DNA damage checkpoint IEA --
GO:0000724 double-strand break repair via homologous recombination TAS --
GO:0006260 DNA replication TAS --
GO:0031573 intra-S DNA damage checkpoint IBA --
genes like me logo Genes that share ontologies with RAD9B: view

No data available for SIGNOR curated interactions for RAD9B Gene

Drugs & Compounds for RAD9B Gene

No Compound Related Data Available

Transcripts for RAD9B Gene

Unigene Clusters for RAD9B Gene

RAD9 homolog B (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD9B Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13
SP1: - - -
SP2:
SP3:

Relevant External Links for RAD9B Gene

GeneLoc Exon Structure for
RAD9B
ECgene alternative splicing isoforms for
RAD9B

Expression for RAD9B Gene

mRNA expression in normal human tissues for RAD9B Gene

mRNA differential expression in normal tissues according to GTEx for RAD9B Gene

This gene is overexpressed in Testis (x18.7).

Protein differential expression in normal tissues from HIPED for RAD9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.8) and Testis (20.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAD9B Gene



SOURCE GeneReport for Unigene cluster for RAD9B Gene Hs.97794

mRNA Expression by UniProt/SwissProt for RAD9B Gene

Q6WBX8-RAD9B_HUMAN
Tissue specificity: Expressed in testis and skeletal muscle.
genes like me logo Genes that share expression patterns with RAD9B: view

Protein tissue co-expression partners for RAD9B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for RAD9B Gene

Orthologs for RAD9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD9B 36
  • 99 (a)
OneToOne
RAD9B 35
  • 99.69 (n)
  • 99.3 (a)
cow
(Bos Taurus)
Mammalia RAD9B 36
  • 69 (a)
OneToOne
RAD9B 35
  • 86.13 (n)
  • 78.2 (a)
dog
(Canis familiaris)
Mammalia RAD9B 35
  • 86.27 (n)
  • 80 (a)
RAD9B 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad9b 16
Rad9b 35
  • 74.4 (n)
  • 64.84 (a)
Rad9b 36
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD9B 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rad9b 35
  • 73.99 (n)
  • 65.91 (a)
chicken
(Gallus gallus)
Aves RAD9B 35
  • 60 (n)
  • 47.34 (a)
RAD9B 36
  • 43 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD9B 36
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad9b 35
  • 57.21 (n)
  • 44.18 (a)
zebrafish
(Danio rerio)
Actinopterygii rad9a 35
  • 55.75 (n)
  • 42.86 (a)
rad9b 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rad9 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hpr-9 36
  • 16 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rad9 35
  • 46.12 (n)
  • 27.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for RAD9B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD9B Gene

ENSEMBL:
Gene Tree for RAD9B (if available)
TreeFam:
Gene Tree for RAD9B (if available)

Paralogs for RAD9B Gene

Paralogs for RAD9B Gene

(1) SIMAP similar genes for RAD9B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RAD9B: view

Variants for RAD9B Gene

Sequence variations from dbSNP and Humsavar for RAD9B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs4766497 -- 110,512,571(+) CCTGA(C/T)TGGTC intron-variant
rs7132104 -- 110,509,154(+) tagta(A/G)agacg intron-variant
rs7307481 -- 110,519,412(+) TGTtt(G/T)ttgtt intron-variant
rs10444494 -- 110,527,959(+) gctga(G/T)ggatg intron-variant
rs11065652 -- 110,504,535(+) ATTCA(A/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD9B Gene

Variant ID Type Subtype PubMed ID
nsv826512 CNV Loss 20364138
esv2746355 CNV Deletion 23290073
esv1243811 CNV Deletion 17803354
nsv507675 CNV Insertion 20534489

Variation tolerance for RAD9B Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD9B Gene

HapMap Linkage Disequilibrium report
RAD9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD9B Gene

Disorders for RAD9B Gene

Relevant External Links for RAD9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD9B

No disorders were found for RAD9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD9B Gene

Publications for RAD9B Gene

  1. Identification and characterization of RAD9B, a paralog of the RAD9 checkpoint gene. (PMID: 14611806) Dufault V.M. … Karnitz L.M. (Genomics 2003) 2 3 4 67
  2. Clamping down on mammalian meiosis. (PMID: 24013428) Lyndaker A.M. … Lieberman H.B. (Cell Cycle 2013) 2 3
  3. Rad9B responds to nucleolar stress through ATR and JNK signalling, and delays the G1-S transition. (PMID: 22399810) PAcrez-Castro A.J. … Freire R. (J. Cell. Sci. 2012) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. (PMID: 16365875) Lieberman H.B. (J. Cell. Biochem. 2006) 3

Products for RAD9B Gene

Sources for RAD9B Gene

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