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RAD9A Gene

protein-coding   GIFtS: 62
GCID: GC11P067159

RAD9 Homolog A (S. Pombe)

(Previous name: RAD9 (S. pombe) homolog)
(Previous symbol: RAD9)
  Search for RAD9A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD9 Homolog A (S. Pombe)1 2     RAD9 (S. Pombe) Homolog1
RAD91 2 5     Cell Cycle Checkpoint Control Protein RAD9A2
DNA Repair Exonuclease Rad9 Homolog A2 3     EC 3.1.11.23
hRAD92 3     

External Ids:    HGNC: 98271   Entrez Gene: 58832   Ensembl: ENSG000001726137   OMIM: 6037615   UniProtKB: Q996383   

Export aliases for RAD9A gene to outside databases

Previous GC identifers: GC11P067409 GC11P066934 GC11P066915 GC11P063487


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD9A Gene:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required
for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may
contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and
HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be
important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Aug 2011)

GeneCards Summary for RAD9A Gene:
RAD9A (RAD9 homolog A (S. pombe)) is a protein-coding gene. GO annotations related to this gene include SH3 domain binding and protein kinase binding. An important paralog of this gene is RAD9B.

UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638
Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double
stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1
complex

Gene Wiki entry for RAD9A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD9A gene promoter:
         p53   Sp1   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAD9A promoter sequence
   Search Chromatin IP Primers for RAD9A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD9A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1-q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.1-q13.2

RAD9A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD9A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067159:  view genomic region     (about GC identifiers)

Start:
67,159,176 bp from pter      End:
67,165,883 bp from pter
Size:
6,708 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638 (See protein sequence)
Recommended Name: Cell cycle checkpoint control protein RAD9A  
Size: 391 amino acids; 42547 Da
Subunit: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1
complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the
RAD17-RFC complex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2.
Interacts with DNAJC7 and RHNO1
3 PDB 3D structures from and Proteopedia for RAD9A:
3A1J (3D)        3G65 (3D)        3GGR (3D)    
Secondary accessions: B2RCZ8 Q6FI29 Q96C41

Explore the universe of human proteins at neXtProt for RAD9A: NX_Q99638

Explore proteomics data for RAD9A at MOPED

Post-translational modifications: 

  • Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated by
    PRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1
    complex1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAD9A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001230153.1  NP_004575.1  

    ENSEMBL proteins: 
     ENSP00000311360   ENSP00000444979   ENSP00000442064   ENSP00000445137  
    Reactome Protein details: Q99638

    RAD9A Human Recombinant Protein Products:

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    Novus Biologicals RAD9A Protein
    Novus Biologicals RAD9A Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for RAD9A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026584 Rad9
     IPR007268 Rad9/Ddc1

    Graphical View of Domain Structure for InterPro Entry Q99638

    ProtoNet protein and cluster: Q99638

    UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638
    Similarity: Belongs to the rad9 family


    Find genes that share domains with RAD9A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD9A_HUMAN, Q99638
    Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The
    9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader
    complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision
    repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for
    the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1
    cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase
    I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of
    RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double
    stranded DNA exonuclease activity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1
    complex
    Catalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates

         Enzyme Number (IUBMB): EC 3.1.11.21

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10359610
    GO:00084083'-5' exonuclease activity IDA10713044
    GO:0008853exodeoxyribonuclease III activity IEA--
    GO:0017124SH3 domain binding IPI11971963
    GO:0019899enzyme binding IPI15326225
         
    Find genes that share ontologies with RAD9A           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for RAD9A:
     Increased Salmonella enterica   Synthetic lethal with paclitax 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rad9a):
     cellular  embryogenesis  homeostasis/metabolism  integument  mortality/aging 
     pigmentation  tumorigenesis 

    Find genes that share phenotypes with RAD9A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad9atm1Lieb for RAD9A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD9A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD9A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD9A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD9A

    miRNA
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    miRTarBase miRNAs that target RAD9A:
    hsa-mir-196a-5p (MIRT026047), hsa-let-7d-5p (MIRT032159)

    Block miRNA regulation of human, mouse, rat RAD9A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD9A (see all 28):
    hsa-miR-485-5p hsa-miR-320a hsa-miR-1287 hsa-miR-15a hsa-miR-503 hsa-miR-766 hsa-miR-1273d hsa-miR-548m
    SwitchGear 3'UTR luciferase reporter plasmidRAD9A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD9A
    Predesigned siRNA for gene silencing in human, mouse, rat RAD9A

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: RAD9A (NM_004584)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9A

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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD9A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAD9A_HUMAN, Q99638: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--
    GO:0030896checkpoint clamp complex IEA--

    Find genes that share ontologies with RAD9A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD9A About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84
    2Chks in Checkpoint Regulation
    Chks in Checkpoint Regulation0.59
    DNA Repair Mechanisms0.32
    3Cell Cycle, Mitotic
    Cell Cycle0.90
    4CDK-mediated phosphorylation and removal of Cdc6
    Cell Cycle Checkpoints0.58
    5Transcription Androgen Receptor nuclear signaling
    Transcription Androgen Receptor nuclear signaling0.49


    Find genes that share SuperPaths with RAD9A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAD9A
        ATM Pathway
    DNA Repair Mechanisms
    Chks in Checkpoint Regulation
    DNA Damage Induced 14-3-3Sigma Signaling

    2 GeneGo (Thomson Reuters) Pathways for RAD9A
        Transcription Androgen Receptor nuclear signaling
    DNA damage ATM/ATR regulation of G1/S checkpoint

    3 BioSystems Pathways for RAD9A
        DNA damage response
    Androgen receptor signaling pathway
    Regulation of Telomerase

    1 Reactome Pathway for RAD9A
        Activation of ATR in response to replication stress


        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD9A: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD9A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD9A (Q996381, 2, 3 ENSP000003113604) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HUS1O609211, 3, ENSP000002587744EBI-2606224,EBI-1056174 I2D: score=4 STRING: ENSP00000258774
    CLSPNQ9HAW42, 3, ENSP000003129954MINT-7897445 I2D: score=3 STRING: ENSP00000312995
    RAD1O606711, 3, ENSP000003408794EBI-2606224,EBI-721835 I2D: score=2 STRING: ENSP00000340879
    RAD17O759432, 3, ENSP000003701514MINT-7897390 I2D: score=4 STRING: ENSP00000370151
    TOPBP1Q925472, 3, ENSP000002608104MINT-3379418 I2D: score=4 STRING: ENSP00000260810
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint ----
    GO:0000076DNA replication checkpoint TAS8943031
    GO:0000077DNA damage checkpoint IMP--
    GO:0006260DNA replication TAS--
    GO:0006281DNA repair IEA--

    Find genes that share ontologies with RAD9A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD9A

    1 Novoseek inferred chemical compound relationship for RAD9A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydroxyurea 59.9 9 12709442 (4), 10852904 (1), 11077446 (1), 11278446 (1)



    Find genes that share compounds with RAD9A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD9A gene (2 alternative transcripts): 
    NM_001243224.1  NM_004584.2  

    Unigene Cluster for RAD9A:

    RAD9 homolog A (S. pombe)
    Hs.655354  [show with all ESTs]
    Unigene Representative Sequence: NM_004584
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543808 ENST00000307980(uc001okr.3 uc021qmg.1) ENST00000544620
    ENST00000538013 ENST00000542139 ENST00000541132 ENST00000530934 ENST00000529100
    ENST00000535644
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAD9A (see all 28):
    hsa-miR-485-5p hsa-miR-320a hsa-miR-1287 hsa-miR-15a hsa-miR-503 hsa-miR-766 hsa-miR-1273d hsa-miR-548m
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      QuantiFast Probe-based Assays in human, mouse, rat RAD9A

    Additional mRNA sequence: 

    AK310213.1 AK315348.1 BC014848.1 CR536508.1 U53174.1 

    16 DOTS entries:

    DT.92465301  DT.100884967  DT.100760796  DT.450687  DT.100009273  DT.40133542  DT.100884968  DT.100019025 
    DT.92465318  DT.100884978  DT.102838908  DT.92465284  DT.92465297  DT.92465314  DT.100884945  DT.97855870 

    Selected AceView cDNA sequences (see all 127):

    CR624269 BQ707208 BE742484 BM918589 BE249853 BQ015195 AK096155 BM845563 
    BC014848 AI261247 BQ882681 BE260538 CA307911 T16617 BF915070 BE293551 
    U53174 NM_004584 BX093492 AA657789 CR536508 BX110033 BQ026878 BG258756 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for RAD9A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10
    SP1:                                                                        
    SP2:                    -                                                   
    SP3:                                                                        
    SP4:                                                                        


    ECgene alternative splicing isoforms for RAD9A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD9A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGAGAATCC
    RAD9A Expression
    About this image


    RAD9A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RAD9A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD9A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655354
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD9A: 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat RAD9A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for RAD9A gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad9a1 , 5 RAD9 homolog (S. pombe)5
    RAD9 homolog A1
    84.49(n)1
    82.26(a)1
      19 (3.89 cM)5
    193671  NM_011237.21  NP_035367.11 
     41951985 
    chicken
    (Gallus gallus)
    Aves RAD9A1 RAD9 homolog A (S. pombe) 66.3(n)
    59.4(a)
      404777  NM_213583.1  NP_998748.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD9A6
    RAD9 homolog A (S. pombe)
    57(a)
    1 ↔ 1
    1(93122861-93137847)
    African clawed frog
    (Xenopus laevis)
    Amphibia Rad92 PCNA-like DNA checkpoint protein Rad9 69(n)    AY253231.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc561972 similar to RAD9 homolog (S. pombe) 74.71(n)   393176  BC045985.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad91 Rad9 47.62(n)
    33.83(a)
      40054  NM_001104169.3  NP_001097639.2 
    worm
    (Caenorhabditis elegans)
    Secernentea hpr-96
    Protein HPR-9 (hpr-9) mRNA, complete cds
    14(a)
    1 → many
    III(10621541-10626383) WBGene00001997


    ENSEMBL Gene Tree for RAD9A (if available)
    TreeFam Gene Tree for RAD9A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD9A gene
    RAD9B2  
    1 SIMAP similar gene for RAD9A using alignment to 6 protein entries:     RAD9A_HUMAN (see all proteins):
    RAD9B

    Find genes that share paralogs with RAD9A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD9A (see all 215)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791171801,2
    F--63485864(+) GAGGGG/AAGCAG 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs178785051,2
    C,F,H--67159847(+) ATCTTC/TCCAGG 2 -- int1 us2k17Minor allele frequency- T:0.01NS NA 882
    rs1929405421,2
    --67159996(+) GGAAAA/GGAGGG 2 -- int1 us2k10--------
    rs1824291661,2
    C--67160210(+) GGCAGC/GCACCC 3 A G mis1 us2k10--------
    rs1384908281,2
    C,F--67160224(+) GTCAGG/AACCTG 3 /N /D mis1 us2k11Minor allele frequency- A:0.00NA 4550
    rs24224901,2,,4
    C,F--67160231(+) CCTGCT/AGCGCT 3 /Q /L mis1 us2k1 ese33Minor allele frequency- A:0.17NA EA 1022
    rs20664911,2
    C,F--67160285(+) CTACTC/TCACCC 2 -- us2k1 int114Minor allele frequency- N:0.00NA EA NS WA CSA EU 2861
    rs16248161,2
    C,F,A--67160321(+) TGCCCT/CGGGGT 2 -- us2k1 int19Minor allele frequency- C:0.14EA NA MN NS WA CSA 538
    rs112277821,2
    C,F--67160322(+) GCCCTG/AGGGTA 2 -- int1 us2k19Minor allele frequency- A:0.03NA NS WA 956
    rs1866623771,2
    --67160338(+) TAGATG/TCTAAG 2 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for RAD9A (67159176 - 67165883 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for RAD9A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv516453CNV Loss19592680
    nsv897796CNV Loss21882294
    nsv897797CNV Loss21882294
    nsv468603CNV Loss19166990
    dgv1194n71CNV Loss21882294
    dgv1193n71CNV Loss21882294
    nsv897801CNV Loss21882294
    esv1010387CNV Loss20482838
    nsv897804CNV Gain21882294

    Human Gene Mutation Database (HGMD): RAD9A
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD9A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD9A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603761    OMIM disorders: --


    Find genes that share disorders with RAD9A           About GenesLikeMe

    5 Novoseek inferred disease relationships for RAD9A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung carcinoma 20.3 2 15558813 (2)
    nsclc 16.6 7 15558813 (3), 18949400 (2)
    tumors 0 19 16204032 (3), 15558813 (3), 18949400 (3), 18616832 (2) (see all 6)
    prostate cancer 0 5 14966297 (2), 16204032 (1)
    cancer 0 9 18949400 (2), 16204032 (1), 17511890 (1), 18616832 (1) (see all 5)

    Genetic Association Database (GAD): RAD9A
    Human Genome Epidemiology (HuGE) Navigator: RAD9A (8 documents)

    Export disorders for RAD9A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD9A gene, integrated from 10 sources (see all 144):
    (articles sorted by number of sources associating them with RAD9A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. (PubMed id 8943031)1, 2, 3 Lieberman H.B.... Davey S. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling. (PubMed id 12709442)1, 2, 9 Roos-Mattjus P.... Karnitz L.M. (J. Biol. Chem. 2003)
    3. Protein kinase Cdelta is responsible for constitutive and DNA damage- induced phosphorylation of Rad9. (PubMed id 12628935)1, 2, 9 Yoshida K.... Kufe D. (EMBO J. 2003)
    4. The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (Biochem. Biophys. Res. Commun. 2001)
    5. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PubMed id 14500360)1, 2, 9 Hopkins K.M....Lieberman H.B. (Cancer Res. 2003)
    6. c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. (PubMed id 11971963)1, 2, 9 Yoshida K.... Kufe D. (Mol. Cell. Biol. 2002)
    7. Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. (PubMed id 10713044)1, 2, 9 Bessho T. and Sancar A. (J. Biol. Chem. 2000)
    8. The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (J. Biol. Chem. 2000)
    9. The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. (PubMed id 10359610)1, 2, 9 St Onge R.P.... Davey S. (Mol. Biol. Cell 1999)
    10. HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. (PubMed id 10846170)1, 2, 9 Cai R.L.... Cohen D. (J. Biol. Chem. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5883 HGNC: 9827 AceView: RAD9A Ensembl:ENSG00000172613 euGenes: HUgn5883
    ECgene: RAD9A H-InvDB: RAD9A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for RAD9A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD9A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad9a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD9A gene:
    Search GeneIP for patents involving RAD9A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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