RAD9A Gene
protein-coding GIFtS: 61
GCID: GC11P067159
|
|
RAD9 homolog A (S. pombe)(Previous name: RAD9 (S. pombe) homolog )
(Previous symbol: RAD9)
| |
Aliases
for RAD9A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAD9 Homolog A (S. Pombe)1 2 | | RAD9 (S. Pombe) Homolog1 | | RAD91 2 5 | | Cell Cycle Checkpoint Control Protein RAD9A2 | | DNA Repair Exonuclease Rad9 Homolog A2 3 | | EC 3.1.11.23 | | HRAD91 | | |
Export aliases for RAD9A gene to outside databasesPrevious GC identifers: GC11P067409 GC11P066934 GC11P066915 GC11P063487 |
Summaries
for RAD9A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAD9A:
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required forcell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute toits role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complexis recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggeringthe checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have beenfound for this gene. (provided by RefSeq, Aug 2011)
UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OHend of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavageactivity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) onlong-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites ofdouble-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonucleaseactivity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex
Gene Wiki entry for RAD9A
|
Genomic Views
for RAD9A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAD9A gene promoter:
p53 Sp1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAD9A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD9A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.1-q13.2 Ensembl cytogenetic band: 11q13.2 HGNC cytogenetic band: 11q13.1-q13.2RAD9A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P067159: view genomic region
(about GC identifiers)
Start:
|
67,159,176 bp from pter |
End:
|
67,165,883 bp from pter |
Size:
|
6,708 bases |
Orientation:
|
plus strand |
|
Proteins
for RAD9A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638 (See
protein sequence)Recommended Name: Cell cycle checkpoint control protein RAD9A Size: 391 amino acids; 42547 Da
Subunit: Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1. The 9-1-1 complexassociates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2. The 9-1-1 complex associates with the RAD17-RFCcomplex. RAD9A interacts with BCL2L1, FEN1, PRKCD, RAD9B, HUS1, RAD1, ABL1, RPA1, ATAD5 and RPA2. Interacts withDNAJC7 and RHNO1
Subcellular location: Nucleus
3 PDB 3D structures from  and Proteopedia  for RAD9A:3A1J (3D)
3G65 (3D)
3GGR (3D)
Secondary accessions: B2RCZ8 Q6FI29 Q96C41Explore the universe of human proteins at neXtProt for RAD9A: NX_Q99638
Post-translational modifications:
Constitutively phosphorylated on serine and threonine amino acids in absence of DNA damage. Hyperphosphorylated byPRKCD and ABL1 upon DNA damage. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complex1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99638
RAD9A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001230153.1 NP_004575.1
ENSEMBL proteins: ENSP00000311360 ENSP00000444979 ENSP00000442064 ENSP00000445137 Reactome Protein details: Q99638
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RAD9A for ontologies About GeneDecksing
RAD9A Antibody Products:
Assay Products for RAD9A: |
Protein
Domains /
Families
for RAD9A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAD9A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q99638ProtoNet protein and cluster: Q99638 UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638Similarity: Belongs to the rad9 family |
Function
for RAD9A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RAD9A_HUMAN, Q99638Function: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex.Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair(LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OHend of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavageactivity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) onlong-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites ofdouble-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonucleaseactivity. Its phosphorylation by PRKCD may be required for the formation of the 9-1-1 complexCatalytic activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphatesEnzyme Number (IUBMB): EC 3.1.11.21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: RAD9A (NM_004584) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD9A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9A |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
RAD9A for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for RAD9A:
Animal Models:
Mouse knock-out Rad9atm1Lieb for RAD9A
7 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Rad9a):
RAD9A for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAD9A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Transcription_Androgen Receptor nuclear signaling | | | 2 | Activation of ATR in response to replication stress | | | 3 | DNA damage ATM/ATR regulation of G1/S checkpoint | | | 4 | Chks in Checkpoint Regulation | | | 5 | Cell Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for RAD9A
4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAD9A
2  GeneGo (Thomson Reuters) Pathways for RAD9A
3  BioSystems Pathways for RAD9A
4 
Reactome Pathways for RAD9A
RAD9A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD9A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/60 Interacting proteins for RAD9A (Q996381, 2, 3 ENSP000003113604) via UniProtKB, MINT, STRING, and/or I2D (see all 60)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HUS1 | O609211, 3, ENSP000002587744 | EBI-2606224,EBI-1056174 I2D:
score=4 STRING: ENSP00000258774 | | CLSPN | Q9HAW42, 3, ENSP000003129954 | MINT-7897445 I2D:
score=3 STRING: ENSP00000312995 | | RAD1 | O606711, 3, ENSP000003408794 | EBI-2606224,EBI-721835 I2D:
score=2 STRING: ENSP00000340879 | | RAD17 | O759432, 3, ENSP000003701514 | MINT-7897390 I2D:
score=4 STRING: ENSP00000370151 | | TOPBP1 | Q925472, 3, ENSP000002608104 | MINT-3379418 I2D:
score=4 STRING: ENSP00000260810 |
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
RAD9A for ontologies About GeneDecksing
|
Drugs & Compounds
for RAD9A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAD9A for compounds About GeneDecksing
 Browse Tocris compounds for RAD9A
1 Novoseek chemical compound relationship for RAD9A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hydroxyurea |
59.9 |
9 |
12709442 (4), 10852904 (1), 11077446 (1), 11278446 (1) |
Search CenterWatch for drugs/clinical trials and news about RAD9A
|
Transcripts
for RAD9A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAD9A gene (2 alternative transcripts): NM_001243224.1 NM_004584.2 Unigene Cluster for RAD9A: RAD9 homolog A (S. pombe) Hs.655354 [show with all ESTs]Unigene Representative Sequence: NM_0045849 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000543808 ENST00000307980(uc001okr.3 uc021qmg.1) ENST00000544620
ENST00000538013 ENST00000542139 ENST00000541132 ENST00000530934 ENST00000529100
ENST00000535644
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: RAD9A (NM_004584) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD9A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9A |
Additional cDNA sequence: AK310213.1 AK315348.1 BC014848.1 CR536508.1 U53174.1 16 DOTS entries: DT.92465301 DT.100884967 DT.100760796 DT.450687 DT.100009273 DT.40133542 DT.100019025 DT.100884968 DT.102838908 DT.92465284 DT.92465297 DT.92465314 DT.100884945 DT.100884978 DT.92465318 DT.97855870 24/127 AceView cDNA sequences (see all 127): BM918589 AK096155 AI024820 BC014848 BE742484 BM845563 BX093492 CA307911 BE260538 CR536508 BQ707208 AI261247 BQ882681 BG258756 BQ015195 BX110033 CR624269 NM_004584 BE249853 T16617 BF915070 BE293551 BQ026878 U53174
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for RAD9A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for RAD9A
|
Expression
for RAD9A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAD9A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAGAATCC
About this image
See RAD9A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAD9A
SOURCE GeneReport for Unigene cluster: Hs.655354
SABiosciences Expression via Pathway-Focused PCR Arrays including RAD9A:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD9A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAD9A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD9A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD9A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9A |
Orthologs
for RAD9A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAD9A gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAD9A1 |
RAD9 homolog A (S. pombe) |
66.3(n)
59.4(a) |
|
404777 NM_213583.1 NP_998748.1 |
lizard
(Anolis carolinensis) |
Reptilia |
RAD9A6 |
-- |
57(a) |
1 ↔ 1 |
1(93126052-93135957) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Rad92 |
PCNA-like DNA checkpoint protein Rad9 |
69(n) |
|
AY253231.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc561972 |
similar to RAD9 homolog (S. pombe) |
74.71(n) |
|
393176 BC045985.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rad91 |
CG3945-PA |
45.89(n)
34.22(a) |
|
40054 NM_001104169.2 NP_001097639.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
hpr-96 |
Homolog of S.Pombe Rad family member (hpr-9) |
15(a) |
1 → many |
III(10621442-10626284) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ATRAD96 |
cell cycle checkpoint control-like protein |
18(a) |
1 → many |
3(1585302-1588722) |
rice
(Oryza sativa) |
Liliopsida |
-- |
auxin response factor 75, putative, expressed |
18(a) |
1 → many |
3(12863946-12868010) |
ENSEMBL Gene Tree for RAD9A (if available)
TreeFam Gene Tree for RAD9A (if available) |
Paralogs
for RAD9A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAD9A gene
- RAD9B2
1 SIMAP similar gene for RAD9A using alignment to 6 protein entries: RAD9A_HUMAN (see all proteins):RAD9B
RAD9A for paralogs About GeneDecksing
|
Genomic Variants
for RAD9A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAD9A (67159176 - 67165883 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for RAD9A
1 CNV: 48873
Human Gene Mutation Database (HGMD): RAD9A
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD9A |
|
Disorders
/ Diseases
for RAD9A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAD9A for disorders About GeneDecksing
OMIM gene information: 603761
OMIM disorders: --
12  diseases for RAD9A: About MalaCardsbloom syndrome intrahepatic cholangiocarcinoma lung carcinoma cholangiocarcinoma
prostate cancer lung adenocarcinoma lung cancer adenocarcinoma
prostatitis breast cancer carcinoma thyroiditis
5 Novoseek disease relationships for RAD9A gene About this table
Human Genome Epidemiology (HuGE) Navigator: RAD9A (8 documents)
Export disorders for RAD9A gene to outside databases
|
Publications
for RAD9A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAD9A gene, integrated from 9 sources (see all 139):
(articles sorted by number of sources associating them with RAD9A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. (PubMed id 8943031)1, 2, 3 Lieberman H.B.... Davey S. (1996)
- Phosphorylation of human Rad9 is required for genotoxin-activated checkpoint signaling. (PubMed id 12709442)1, 2, 9 Roos-Mattjus P.... Karnitz L.M. (2003)
- Protein kinase Cdelta is responsible for constitutive and DNA damage- induced phosphorylation of Rad9. (PubMed id 12628935)1, 2, 9 Yoshida K.... Kufe D. (2003)
- The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9. (PubMed id 11573955)1, 2, 9 Xiang S.L....Yamamoto K.C. (2001)
- Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PubMed id 14500360)1, 2, 9 Hopkins K.M....Lieberman H.B. (2003)
- c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage. (PubMed id 11971963)1, 2, 9 Yoshida K.... Kufe D. (2002)
- Human DNA damage checkpoint protein hRAD9 is a 3' to 5' exonuclease. (PubMed id 10713044)1, 2, 9 Bessho T. and Sancar A. (2000)
- The human checkpoint protein hRad17 interacts with the PCNA-like proteins hRad1, hHus1, and hRad9. (PubMed id 10884395)1, 2, 9 Rauen M.... Karnitz L.M. (2000)
- The human G2 checkpoint control protein hRAD9 is a nuclear phosphoprotein that forms complexes with hRAD1 and hHUS1. (PubMed id 10359610)1, 2, 9 St Onge R.P.... Davey S. (1999)
- HDAC1, a histone deacetylase, forms a complex with Hus1 and Rad9, two G2/M checkpoint Rad proteins. (PubMed id 10846170)1, 2, 9 Cai R.L.... Cohen D. (2000)
|
External Searches for RAD9A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing RAD9A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing RAD9A gene
(According to HUGE)
About This Section
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Specialized Databases showing RAD9A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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About This Section
| Patent Information for RAD9A gene:
Search GeneIP for patents involving RAD9A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAD9A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RAD9A | | OriGene shRNA RFP for RAD9A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD9A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD9A | | | OriGene Protein Over-expression Lysate for RAD9A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAD9A | | OriGene 3'-UTR Clone for RAD9A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD9A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for RAD9A | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAD9A | | OriGene Custom Protein Services for RAD9A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAD9A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD9A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD9A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD9A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD9A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD9A |
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| | | | Search Tocris compounds for RAD9A |
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 | | | RAD9A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD9A |
|  |  |  | | | | ThermoFisher Antibody for RAD9A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD9A |
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