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Aliases for RAD54L2 Gene

Aliases for RAD54L2 Gene

  • RAD54-Like 2 (S. Cerevisiae) 2 3
  • Androgen Receptor-Interacting Protein 4 3 4
  • RAD54-Like Protein 2 3 4
  • ARIP4 3 4
  • Helicase ARIP4 3
  • EC 4
  • SRISNF2L 3
  • KIAA0809 4
  • EC 3.6.1 64
  • HSPC325 3

External Ids for RAD54L2 Gene

Summaries for RAD54L2 Gene

GeneCards Summary for RAD54L2 Gene

RAD54L2 (RAD54-Like 2 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and helicase activity. An important paralog of this gene is RAD54L.

UniProtKB/Swiss-Prot for RAD54L2 Gene

  • DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD54L2 Gene

Genomics for RAD54L2 Gene

Genomic Location for RAD54L2 Gene

51,538,910 bp from pter
51,668,667 bp from pter
129,758 bases
Plus strand

Genomic View for RAD54L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD54L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD54L2 Gene

Regulatory Elements for RAD54L2 Gene

Proteins for RAD54L2 Gene

  • Protein details for RAD54L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Helicase ARIP4
    Protein Accession:
    Secondary Accessions:
    • Q8TB57
    • Q9BV54

    Protein attributes for RAD54L2 Gene

    1467 amino acids
    Molecular mass:
    162769 Da
    Quaternary structure:
    • Interacts with AR via its N-terminus. Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not seem to form large multiprotein complexes (By similarity).
    • Sequence=AAH24298.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for RAD54L2 Gene

Proteomics data for RAD54L2 Gene at MOPED

Selected DME Specific Peptides for RAD54L2 Gene

Post-translational modifications for RAD54L2 Gene

Other Protein References for RAD54L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for RAD54L2 Gene

Protein Domains for RAD54L2 Gene


  • Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.:
    • Q9Y4B4
  • Contains 1 helicase ATP-binding domain.:
    • Q9Y4B4
  • Contains 1 helicase C-terminal domain.:
    • Q9Y4B4
  • Belongs to the SNF2/RAD54 helicase family.:
    • Q9Y4B4
genes like me logo Genes that share domains with RAD54L2: view

No data available for Gene Families for RAD54L2 Gene

Function for RAD54L2 Gene

Molecular function for RAD54L2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + H(2)O = ADP + phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA).
UniProtKB/Swiss-Prot Function: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

Enzyme Numbers (IUBMB) for RAD54L2 Gene

Gene Ontology (GO) - Molecular Function for RAD54L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003712 transcription cofactor activity IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with RAD54L2: view

Phenotypes for RAD54L2 Gene

genes like me logo Genes that share phenotypes with RAD54L2: view

miRNA for RAD54L2 Gene

miRTarBase miRNAs that target RAD54L2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for RAD54L2 Gene

Localization for RAD54L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD54L2 Gene

Nucleus. Note=Localizes in speckle-like nuclear compartments. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for RAD54L2 Gene COMPARTMENTS Subcellular localization image for RAD54L2 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for RAD54L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RAD54L2: view

Pathways for RAD54L2 Gene

SuperPathways for RAD54L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAD54L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:1903506 regulation of nucleic acid-templated transcription IEA --
GO:2001141 regulation of RNA biosynthetic process --
genes like me logo Genes that share ontologies with RAD54L2: view

No data available for Pathways by source for RAD54L2 Gene

Transcripts for RAD54L2 Gene

Unigene Clusters for RAD54L2 Gene

RAD54-like 2 (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD54L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -

Relevant External Links for RAD54L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAD54L2 Gene

mRNA expression in normal human tissues for RAD54L2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD54L2 Gene

SOURCE GeneReport for Unigene cluster for RAD54L2 Gene Hs.105399

genes like me logo Genes that share expressions with RAD54L2: view

Orthologs for RAD54L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD54L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAD54L2 36
  • 99.77 (n)
  • 99.86 (a)
RAD54L2 37
  • 100 (a)
(Bos Taurus)
Mammalia RAD54L2 36
  • 91.49 (n)
  • 95.45 (a)
RAD54L2 37
  • 93 (a)
(Canis familiaris)
Mammalia RAD54L2 36
  • 93.37 (n)
  • 97.27 (a)
RAD54L2 37
  • 97 (a)
(Mus musculus)
Mammalia Rad54l2 36
  • 91.13 (n)
  • 95.43 (a)
Rad54l2 16
Rad54l2 37
  • 96 (a)
(Monodelphis domestica)
Mammalia RAD54L2 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia RAD54L2 37
  • 80 (a)
(Rattus norvegicus)
Mammalia Rad54l2 36
  • 90.85 (n)
  • 95.28 (a)
(Gallus gallus)
Aves RAD54L2 36
  • 75.76 (n)
  • 79.05 (a)
RAD54L2 37
  • 78 (a)
(Anolis carolinensis)
Reptilia RAD54L2 37
  • 77 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398513 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rad54l2 36
  • 66.3 (n)
  • 68.97 (a)
Str.15166 36
(Danio rerio)
Actinopterygii rad54l2 36
  • 64.04 (n)
  • 67.25 (a)
rad54l2 37
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4049 36
  • 52.27 (n)
  • 48.15 (a)
CG4049 37
  • 33 (a)
(Caenorhabditis elegans)
Secernentea rad-26 37
  • 32 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD54 37
  • 21 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8964 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
Species with no ortholog for RAD54L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD54L2 Gene

Gene Tree for RAD54L2 (if available)
Gene Tree for RAD54L2 (if available)

Paralogs for RAD54L2 Gene

Paralogs for RAD54L2 Gene

Selected SIMAP similar genes for RAD54L2 Gene using alignment to 3 proteins: Pseudogenes for RAD54L2 Gene

genes like me logo Genes that share paralogs with RAD54L2: view

Variants for RAD54L2 Gene

Sequence variations from dbSNP and Humsavar for RAD54L2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs904145 -- 51,663,477(-) GCCTT(C/T)CAGCT utr-variant-3-prime, nc-transcript-variant
rs2279721 -- 51,665,177(-) GGTGG(C/G)GGATA utr-variant-3-prime, nc-transcript-variant
rs2666533 -- 51,651,413(+) AAGAG(A/G)GAATC intron-variant
rs4234644 -- 51,661,849(+) ATCAT(C/G)TCATT intron-variant
rs4280628 -- 51,591,066(+) GCTGC(A/G)CTACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD54L2 Gene

Variant ID Type Subtype PubMed ID
esv2423095 CNV Insertion 19546169
nsv512801 CNV Insertion 21212237
esv1042021 CNV Insertion 17803354
nsv508921 CNV Insertion 20534489

Relevant External Links for RAD54L2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for RAD54L2 Gene

Relevant External Links for RAD54L2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with RAD54L2: view

No data available for UniProtKB/Swiss-Prot for RAD54L2 Gene

Publications for RAD54L2 Gene

  1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Purification and identification of endogenous polySUMO conjugates. (PMID: 21252943) Bruderer R. … Hay R.T. (EMBO Rep. 2011) 3
  5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PMID: 21693764) Tatham M.H. … Hay R.T. (Sci Signal 2011) 3

Products for RAD54L2 Gene

Sources for RAD54L2 Gene

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