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RAD54L2 Gene

protein-coding   GIFtS: 55
GCID: GC03P051637

RAD54-Like 2 (S. Cerevisiae)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD54-Like 2 (S. Cerevisiae)1 2     SRISNF2L2
Androgen Receptor-Interacting Protein 42 3     Helicase ARIP42
ARIP42 3     EC 3.6.4.123
RAD54-Like Protein 22 3     KIAA08093
HSPC3252     EC 3.6.18

External Ids:    HGNC: 291231   Entrez Gene: 231322   Ensembl: ENSG000001640807   UniProtKB: Q9Y4B43   

Export aliases for RAD54L2 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for RAD54L2 Gene:
RAD54L2 (RAD54-like 2 (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include protein kinase binding and helicase activity. An important paralog of this gene is ATRX.

UniProtKB/Swiss-Prot: ARIP4_HUMAN, Q9Y4B4
Function: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent
manner. Not able to remodel mononucleosomes in vitro (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD54L2 gene promoter:
         AP-1   p53   NF-E2 p45   MEF-2A   c-Rel   FOXC1   COMP1   HFH-1   aMEF-2   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD54L2 promoter sequence
   Search Chromatin IP Primers for RAD54L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD54L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.2   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.2

RAD54L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD54L2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P051637:  view genomic region     (about GC identifiers)

Start:
51,575,160 bp from pter      End:
51,702,683 bp from pter
Size:
127,524 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARIP4_HUMAN, Q9Y4B4 (See protein sequence)
Recommended Name: Helicase ARIP4  
Size: 1467 amino acids; 162769 Da
Subunit: Interacts with AR via its N-terminus. Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not
seem to form large multiprotein complexes (By similarity)
Sequence caution: Sequence=AAH24298.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8TB57 Q9BV54

Explore the universe of human proteins at neXtProt for RAD54L2: NX_Q9Y4B4

Explore proteomics data for RAD54L2 at MOPED

Post-translational modifications: 

  • Sumoylated (By similarity)1
  • Ubiquitination2 at Lys450, Lys665, Lys682, Lys856
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for RAD54L2 (Q9Y4B4) (see all 5)
     MGLGKTL  LVFSQSL  FLLSTRA  TVLAIVP 


    See RAD54L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055921.2  
    ENSEMBL proteins: 
     ENSP00000386520   ENSP00000410283   ENSP00000296477  

    RAD54L2 Human Recombinant Protein Products:

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    Search eBioscience for ELISAs for RAD54L2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR000330 SNF2_N
     IPR027417 P-loop_NTPase
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9Y4B4

    ProtoNet protein and cluster: Q9Y4B4

    1 Blocks protein domain: IPB000330 SNF2 related domain

    UniProtKB/Swiss-Prot: ARIP4_HUMAN, Q9Y4B4
    Domain: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors
    (By similarity)
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Find genes that share domains with RAD54L2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARIP4_HUMAN, Q9Y4B4
    Function: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent
    manner. Not able to remodel mononucleosomes in vitro (By similarity)
    Catalytic activity: ATP + H(2)O = ADP + phosphate
    Enzyme regulation: Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA) (By
    similarity)

         Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.121

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003712transcription cofactor activity IEA--
    GO:0004386helicase activity IEA--
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with RAD54L2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD54L2:
     Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad54l2):
     cellular  embryogenesis  growth/size/body  mortality/aging  nervous system 

    Find genes that share phenotypes with RAD54L2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD54L2
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    miRNA
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    miRTarBase miRNAs that target RAD54L2:
    hsa-mir-26b-5p (MIRT029085)

    Block miRNA regulation of human, mouse, rat RAD54L2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RAD54L2:
    hsa-miR-654-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidRAD54L2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD54L2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RAD54L2 (NM_015106)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54L2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARIP4_HUMAN, Q9Y4B4: Nucleus (By similarity). Note=Localizes in speckle-like nuclear compartments (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with RAD54L2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for RAD54L2
    Interactions:

        Search GeneGlobe Interaction Network for RAD54L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD54L2 (Q9Y4B42, 3 ENSP000003865204) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2870575 MINT-2870594 I2D: score=3 STRING: ENSP00000244769
    ATN1P542592, 3, ENSP000003490764MINT-2870556 I2D: score=3 STRING: ENSP00000349076
    UBE2IP632793, ENSP000003248974I2D: score=3 STRING: ENSP00000324897
    ARP102753, ENSP000003638224I2D: score=2 STRING: ENSP00000363822
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD54L2 (ARIP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD54L2 gene: 
    NM_015106.2  

    Unigene Cluster for RAD54L2:

    RAD54-like 2 (S. cerevisiae)
    Hs.105399  [show with all ESTs]
    Unigene Representative Sequence: AK023824
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602430 ENST00000487093(uc003dbh.3) ENST00000409535(uc011bdt.2 uc011bdu.2)
    ENST00000432863 ENST00000462377 ENST00000461680(uc003dbj.3) ENST00000296477

    miRNA
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    Block miRNA regulation of human, mouse, rat RAD54L2 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate RAD54L2:
    hsa-miR-654-5p hsa-miR-541
    SwitchGear 3'UTR luciferase reporter plasmidRAD54L2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RAD54L2
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAD54L2 (NM_015106)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54L2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54L2
    Primer
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    OriGene qPCR primer pairs and template standards for RAD54L2
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD54L2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD54L2
      QuantiTect SYBR Green Assays in human, mouse, rat RAD54L2
      QuantiFast Probe-based Assays in human, mouse, rat RAD54L2

    Additional mRNA sequence: 

    AB018352.2 AF161443.1 AK023824.1 AK025049.1 AK026053.1 AK122683.1 AK304881.1 AK308456.1 
    BC001474.2 BC024298.1 

    8 DOTS entries:

    DT.110528  DT.97839806  DT.100751113  DT.97839805  DT.40258200  DT.120847094  DT.99997439  DT.91983946 

    15 AceView cDNA sequences:

    BX099489 AF088021 N57617 BM904026 N52795 AA694361 AA701493 AA824397 
    BP873245 AA704169 AA679584 AI247512 BU178518 BI061514 BG165637 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RAD54L2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                                -                                                                                                               
    SP2:                                -                 -                                                                                             
    SP3:                                                                                                                                                


    ECgene alternative splicing isoforms for RAD54L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD54L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGTTGCCGA
    RAD54L2 Expression
    About this image

    RAD54L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD54L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.105399
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54L2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAD54L2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad54l21 , 5 RAD54 like 2 (S. cerevisiae)1, 5 91.13(n)1
    95.43(a)1
      9 (57.98 cM)5
    810001  NM_030730.21  NP_109655.21 
     1066880825 
    chicken
    (Gallus gallus)
    Aves RAD54L21 RAD54-like 2 (S. cerevisiae) 75.76(n)
    79.05(a)
      415933  XM_004944446.1  XP_004944503.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD54L26
    RAD54-like 2 (S. cerevisiae)
    77(a)
    1 ↔ 1
    2(152201449-152314983)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985132 similar to steroid receptor-interacting SNF2 domain more 75.41(n)    BC044266.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rad54l21 RAD54-like 2 (S. cerevisiae) 64.04(n)
    67.25(a)
      558947  XM_005174005.1  XP_005174062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG40491 CG4049 52.27(n)
    48.15(a)
      37860  NM_138041.2  NP_611885.3 
    worm
    (Caenorhabditis elegans)
    Secernentea rad-266
    Protein RAD-26 (rad-26) mRNA, complete cds
    32(a)
    1 ↔ 1
    IV(8894081-8901385) WBGene00007761
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD546
    DNA-dependent ATPase, stimulates strand exchange b...
    21(a)
    1 → many
    VII(193707-196403) YGL163C


    ENSEMBL Gene Tree for RAD54L2 (if available)
    TreeFam Gene Tree for RAD54L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD54L2 gene
    ATRX2  RAD54L2  RAD54B2  
    1 SIMAP similar gene for RAD54L2 using alignment to 3 protein entries:     ARIP4_HUMAN (see all proteins):
    ATRX

    Find genes that share paralogs with RAD54L2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RAD54L2
    PGOHUM00000234624


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD54L2 (see all 1942)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710841501,2
    C--51607078(-) TTATG-/GACAAAG 1 -- int11Minor allele frequency- GA:0.00NA 2
    rs1382239281,2
    --51634395(+) TGGTGG/TCAGCC 1 -- us2k10--------
    rs1125323541,2
    F--51634823(+) CAGGCG/ATTTTC 1 -- us2k12Minor allele frequency- A:0.05CSA WA 119
    rs1431211521,2
    C--51634962(+) CCTTAA/CATCCA 1 -- us2k10--------
    rs1122954681,2
    C,F--51635067(+) GGACAC/TTGTCT 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1418441041,2
    --51635155(+) CAGTAC/TGCAAA 1 -- us2k10--------
    rs1117821111,2
    C,F--51635161(+) GCAAAC/ATCCAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1916981551,2
    --51635277(+) ACAGTA/GTCAGA 1 -- us2k10--------
    rs1437230821,2
    C--51635349(+) ACTTT-/CAAGTG
            
    CAATG
    1 -- us2k10--------
    rs1835286671,2
    --51635408(+) GTAAAC/TATTAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD54L2 (51575160 - 51702683 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAD54L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv512801CNV Insertion21212237
    esv2423095CNV Insertion19546169
    nsv508921CNV Insertion20534489
    esv1042021CNV Insertion17803354

    Human Gene Mutation Database (HGMD): RAD54L2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD54L2
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD54L2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with RAD54L2           About GenesLikeMe

    Genetic Association Database (GAD): RAD54L2
    Human Genome Epidemiology (HuGE) Navigator: RAD54L2 (1 document)

    Export disorders for RAD54L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD54L2 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with RAD54L2)
        Utopia: connect your pdf to the dynamic
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    1. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9872452)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    4. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23132 HGNC: 29123 AceView: SRISNF2L.2 Ensembl:ENSG00000164080 euGenes: HUgn23132
    ECgene: RAD54L2 H-InvDB: RAD54L2

    (According to HUGE)
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    HUGE: KIAA0809

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD54L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD54L2 gene:
    Search GeneIP for patents involving RAD54L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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