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Aliases for RAD54L2 Gene

Aliases for RAD54L2 Gene

  • RAD54-Like 2 (S. Cerevisiae) 2 3 5
  • Androgen Receptor-Interacting Protein 4 3 4
  • AR Interacting Protein 4 2 3
  • RAD54-Like Protein 2 3 4
  • ARIP4 3 4
  • Helicase ARIP4 3
  • EC 3.6.4.12 4
  • SRISNF2L 3
  • KIAA0809 4
  • EC 3.6.1 61
  • HSPC325 3

External Ids for RAD54L2 Gene

Previous GeneCards Identifiers for RAD54L2 Gene

  • GC03P051637

Summaries for RAD54L2 Gene

GeneCards Summary for RAD54L2 Gene

RAD54L2 (RAD54-Like 2 (S. Cerevisiae)) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and helicase activity. An important paralog of this gene is ATRX.

UniProtKB/Swiss-Prot for RAD54L2 Gene

  • DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD54L2 Gene

Genomics for RAD54L2 Gene

Regulatory Elements for RAD54L2 Gene

Enhancers for RAD54L2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F052021 1.2 Ensembl ENCODE 17.5 +484.2 484180 3.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF143 RAD54L2 RRP9 GPR62 GC03P052016 LOC105377088
GH03F052236 0.9 FANTOM5 ENCODE 15.7 +700.1 700106 5.2 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 GLYCTK LOC101929054 RAD54L2 WDR82 NEK4 MIR135A1 GLYCTK-AS1 RRP9 TWF2 PPM1M
GH03F050816 0.5 ENCODE 15.2 -720.7 -720740 2.9 PKNOX1 ZNF146 MAX REST ZNF558 RAD54L2 TEX264 HEMK1 ENSG00000273356 GC03M050811 ST13P14
GH03F051383 1.1 ENCODE 13.4 -150.5 -150482 9.5 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS PAF1 RRP9 RAD54L2 HEMK1 TEX264 GRM2 CACNA2D2 GPR62 PCBP4 MANF PIR60056
GH03F050636 0.8 Ensembl ENCODE 12.1 -900.7 -900653 3.7 CTCF RING1 CEBPG RAD21 ZNF335 HIC1 ZFHX2 SCRT2 PATZ1 ZBTB20 RAD54L2 ENSG00000230454 NPRL2 HEMK1 LSMEM2 NAT6 CISH ENSG00000273356
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAD54L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAD54L2 Gene

Chromosome:
3
Start:
51,538,683 bp from pter
End:
51,668,667 bp from pter
Size:
129,985 bases
Orientation:
Plus strand

Genomic View for RAD54L2 Gene

Genes around RAD54L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD54L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD54L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD54L2 Gene

Proteins for RAD54L2 Gene

  • Protein details for RAD54L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4B4-ARIP4_HUMAN
    Recommended name:
    Helicase ARIP4
    Protein Accession:
    Q9Y4B4
    Secondary Accessions:
    • Q8TB57
    • Q9BV54

    Protein attributes for RAD54L2 Gene

    Size:
    1467 amino acids
    Molecular mass:
    162769 Da
    Quaternary structure:
    • Interacts with AR via its N-terminus. Interacts with DYRK1A. Binds DNA and mononucleosomes, but does not seem to form large multiprotein complexes (By similarity).
    SequenceCaution:
    • Sequence=AAH24298.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for RAD54L2 Gene

Selected DME Specific Peptides for RAD54L2 Gene

Q9Y4B4:
  • LVFSQSL
  • FDASWNP
  • MGLGKTL
  • TVLAIVP
  • FLLSTRA

Post-translational modifications for RAD54L2 Gene

Other Protein References for RAD54L2 Gene

Domains & Families for RAD54L2 Gene

Protein Domains for RAD54L2 Gene

Suggested Antigen Peptide Sequences for RAD54L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4B4

UniProtKB/Swiss-Prot:

ARIP4_HUMAN :
  • Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to be important for the association with nuclear receptors.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with RAD54L2: view

No data available for Gene Families for RAD54L2 Gene

Function for RAD54L2 Gene

Molecular function for RAD54L2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA).
UniProtKB/Swiss-Prot Function:
DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro (By similarity).

Enzyme Numbers (IUBMB) for RAD54L2 Gene

Gene Ontology (GO) - Molecular Function for RAD54L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with RAD54L2: view
genes like me logo Genes that share phenotypes with RAD54L2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAD54L2

miRNA for RAD54L2 Gene

miRTarBase miRNAs that target RAD54L2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAD54L2 Gene

Localization for RAD54L2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD54L2 Gene

Nucleus. Note=Localizes in speckle-like nuclear compartments. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD54L2 Gene COMPARTMENTS Subcellular localization image for RAD54L2 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for RAD54L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RAD54L2: view

Pathways & Interactions for RAD54L2 Gene

SuperPathways for RAD54L2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAD54L2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RAD54L2 Gene

Drugs & Compounds for RAD54L2 Gene

(3) Drugs for RAD54L2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for RAD54L2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with RAD54L2: view

Transcripts for RAD54L2 Gene

Unigene Clusters for RAD54L2 Gene

RAD54-like 2 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD54L2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: -
SP2: - -
SP3:

Relevant External Links for RAD54L2 Gene

GeneLoc Exon Structure for
RAD54L2
ECgene alternative splicing isoforms for
RAD54L2

Expression for RAD54L2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAD54L2 Gene

Protein differential expression in normal tissues from HIPED for RAD54L2 Gene

This gene is overexpressed in Fetal heart (41.0) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD54L2 Gene



Protein tissue co-expression partners for RAD54L2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAD54L2 Gene:

RAD54L2

SOURCE GeneReport for Unigene cluster for RAD54L2 Gene:

Hs.105399
genes like me logo Genes that share expression patterns with RAD54L2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAD54L2 Gene

Orthologs for RAD54L2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD54L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD54L2 34 35
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia RAD54L2 34 35
  • 93.37 (n)
cow
(Bos Taurus)
Mammalia RAD54L2 34 35
  • 91.49 (n)
mouse
(Mus musculus)
Mammalia Rad54l2 34 16 35
  • 91.13 (n)
rat
(Rattus norvegicus)
Mammalia Rad54l2 34
  • 90.85 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD54L2 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD54L2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD54L2 34 35
  • 75.76 (n)
lizard
(Anolis carolinensis)
Reptilia RAD54L2 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad54l2 34
  • 66.3 (n)
Str.15166 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398513 34
zebrafish
(Danio rerio)
Actinopterygii rad54l2 34 35
  • 64.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4049 34 35
  • 52.27 (n)
worm
(Caenorhabditis elegans)
Secernentea rad-26 35
  • 32 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD54 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 58 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8964 34
Species where no ortholog for RAD54L2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD54L2 Gene

ENSEMBL:
Gene Tree for RAD54L2 (if available)
TreeFam:
Gene Tree for RAD54L2 (if available)

Paralogs for RAD54L2 Gene

Paralogs for RAD54L2 Gene

(1) SIMAP similar genes for RAD54L2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for RAD54L2 Gene

genes like me logo Genes that share paralogs with RAD54L2: view

Variants for RAD54L2 Gene

Sequence variations from dbSNP and Humsavar for RAD54L2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10529342 -- 51,558,478(+) TCTCT(-/CTCT/CTCTCTCT)TTTTT intron-variant
rs10559277 -- 51,582,388(+) TTTCC(-/TCT)TCTTA intron-variant
rs111226911 -- 51,558,480(+) CTCTT(C/T)TTTGA intron-variant
rs111227414 -- 51,562,036(+) GTTAA(-/T)TTTTT intron-variant
rs111249562 -- 51,604,964(+) TTGCC(C/T)AGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD54L2 Gene

Variant ID Type Subtype PubMed ID
esv1042021 CNV insertion 17803354
esv2423095 CNV insertion 19546169
esv3310516 CNV novel sequence insertion 20981092
esv3414786 CNV duplication 20981092
esv3596156 CNV loss 21293372
nsv479004 CNV novel sequence insertion 20440878
nsv508921 CNV insertion 20534489
nsv512801 CNV insertion 21212237
nsv999553 CNV gain 25217958

Variation tolerance for RAD54L2 Gene

Residual Variation Intolerance Score: 3.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD54L2 Gene

Human Gene Mutation Database (HGMD)
RAD54L2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD54L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD54L2 Gene

Disorders for RAD54L2 Gene

Relevant External Links for RAD54L2

Genetic Association Database (GAD)
RAD54L2
Human Genome Epidemiology (HuGE) Navigator
RAD54L2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD54L2

No disorders were found for RAD54L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD54L2 Gene

Publications for RAD54L2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1. (PMID: 19692572) Ogawa H. … Morohashi K. (Mol. Biol. Cell 2009) 2 3 64
  3. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T. … Ohara O. (DNA Res. 1998) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for RAD54L2 Gene

Sources for RAD54L2 Gene

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