Aliases for RAD54L Gene
Aliases for RAD54L Gene
External Ids for RAD54L Gene
- HGNC: 9826
- Entrez Gene: 8438
- Ensembl: ENSG00000085999
- OMIM: 603615
- UniProtKB: Q92698
Previous GeneCards Identifiers for RAD54L Gene
- GC01P046407
- GC01P045670
- GC01P046099
- GC01P046083
- GC01P046425
- GC01P046485
- GC01P046713
- GC01P044829
Summaries for RAD54L Gene
-
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
GeneCards Summary for RAD54L Gene
RAD54L (RAD54 Like) is a Protein Coding gene. Diseases associated with RAD54L include Lymphoma, Non-Hodgkin, Familial and Colon Adenocarcinoma. Among its related pathways are DNA Damage and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is RAD54B.
UniProtKB/Swiss-Prot for RAD54L Gene
-
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
Additional gene information for RAD54L Gene
- Monarch Initiative
- Search for RAD54L at DataMed
- Search for RAD54L at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD54L Gene
Genomics for RAD54L Gene
GeneHancer (GH) Regulatory Elements for RAD54L Gene
Regulatory Element Products
Genomic Locations for RAD54L Gene
- chr1:46,247,688-46,278,473
- (GRCh38/hg38)
- Size:
- 30,786 bases
- Orientation:
- Plus strand
- chr1:46,713,360-46,744,145
- (GRCh37/hg19)
Genomic View for RAD54L Gene
- Cytogenetic band:
-
- 1p34.1 by Ensembl
- 1p34.1 by Entrez Gene
- 1p34.1 by HGNC


RefSeq DNA sequence for RAD54L Gene
Proteins for RAD54L Gene
-
Protein details for RAD54L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92698-RAD54_HUMAN
- Recommended name:
- DNA repair and recombination protein RAD54-like
- Protein Accession:
- Q92698
- Q5TE31
- Q6IUY3
Protein attributes for RAD54L Gene
- Size:
- 747 amino acids
- Molecular mass:
- 84352 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with RAD51.
Protein Expression for RAD54L Gene
Selected DME Specific Peptides for RAD54L Gene
- Q92698:
-
- GTIEEKI
- DEMGLGKT
- LRPHQREG
- DILSKYLPVK
- MGLGKTL
- LMWTLLRQ
- RVWRDGQK
Post-translational modifications for RAD54L Gene
- Ubiquitination at Lys302
Other Protein References for RAD54L Gene
Antibody Products
- Cell Signaling Technology (CST) Antibodies for RAD54L (RAD54L)
-
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-
Abcam antibodies for RAD54L
- Invitrogen Antibodies for RAD54L
- GeneTex RAD54L antibody for RAD54L
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD54L
Protein Products
-
OriGene Purified Proteins for RAD54L
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- Search GeneTex for Proteins for RAD54L
-
Abcam proteins for RAD54L
Assay Products
Domains & Families for RAD54L Gene
Gene Families for RAD54L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAD54L Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RAD54L Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q92698- Family:
-
- Belongs to the SNF2/RAD54 helicase family.
Function for RAD54L Gene
Molecular function for RAD54L Gene
- GENATLAS Biochemistry:
- yeast (S cerevisiae) RAD54 homolog,93kDa,SNF2/SW12 family,highly expressed in organs of germ cells and lymphoid development,recombinational protein associated with RAD51,involved in nucleotide excision repair of double-strand break and in meiotic recombination,RAD52 epistasis group,localized in a region of high loss of heterozygosity in breast cancer,potential tumor suppressor in parathyroid adenomas (see TSG1J) and in breast cancer with poor prognosis
- UniProtKB/Swiss-Prot Function:
- Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
- UniProtKB/Swiss-Prot Induction:
- Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle.
Enzyme Numbers (IUBMB) for RAD54L Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0004386 | helicase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 16990250 |
GO:0005524 | ATP binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for RAD54L Gene
- MGI mutant phenotypes for RAD54L:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RAD54L:
Animal Models for RAD54L Gene
- MGI Knock Outs for RAD54L:
-
- Rad54l tm1Jhjh
Animal Model Products
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-
-
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-
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-
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miRNA for RAD54L Gene
- miRTarBase miRNAs that target RAD54L
miRNA Products
- Search ViGene Biosciences for RAD54L
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RAD54L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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Horizon Cell Lines for RAD54L
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-
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-
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No data available for Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for RAD54L Gene
Localization for RAD54L Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD54L Gene
- Nucleus.
- Nucleoplasm (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS | 8805304 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0043234 | protein complex | IMP | 16990250 |
Pathways & Interactions for RAD54L Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | ||
2 | DNA Damage | ||
3 | Integrated Breast Cancer Pathway |
Pathways by source for RAD54L Gene
1 Cell Signaling Technology pathway for RAD54L Gene
1 BioSystems pathway for RAD54L Gene
1 KEGG pathway for RAD54L Gene
Interacting Proteins for RAD54L Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000724 | double-strand break repair via homologous recombination | IEA | -- |
GO:0000733 | DNA strand renaturation | IEA | -- |
GO:0006281 | DNA repair | TAS | 8805304 |
GO:0006302 | double-strand break repair | IEA | -- |
GO:0006310 | DNA recombination | TAS | 8805304 |
No data available for SIGNOR curated interactions for RAD54L Gene
Transcripts for RAD54L Gene
mRNA/cDNA for RAD54L Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (132) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RAD54L Gene
CRISPR Products
-
OriGene CRISPR knockouts for RAD54L
- genomics-online: gRNA clones - Search results for 120 available RAD54L gene related products
- Overview of 120 available RAD54L gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD54L
- GenScript: Design CRISPR guide RNA sequences for RAD54L
miRNA Products
- Search ViGene Biosciences for RAD54L
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD54L
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- Overview of 120 available RAD54L gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD54L gene
Clone Products
- Sino Biological Human cDNA Clone for RAD54L
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- VectorBuilder custom plasmid, inducible vectors for RAD54L
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD54L
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RAD54L
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
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SP5: |
Expression for RAD54L Gene
mRNA differential expression in normal tissues according to GTEx for RAD54L Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD54L Gene
NURSA nuclear receptor signaling pathways regulating expression of RAD54L Gene:
RAD54LSOURCE GeneReport for Unigene cluster for RAD54L Gene:
Hs.642042Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD54L Gene
- ectoderm
- mesoderm
- immune
- integumentary
- reproductive
- skeletal muscle
- breast
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for RAD54L
- genomics-online: primer clones - Search results for 120 available RAD54L gene related products
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for RAD54L Gene
Orthologs for RAD54L Gene
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RAD54L 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | RAD54L 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | RAD54L 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Rad54l 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rad54l 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | RAD54L 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | RAD54L 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | RAD54L 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | RAD54L 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rad54l 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | rad54l 33 34 |
|
||
zgc56289 33 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008748 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | okr 35 33 34 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | rad-54 33 34 |
|
||
Y116A8C.13 35 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD54 33 34 36 |
|
||
A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AEL297W 33 |
|
||
K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A03069g 33 |
|
||
thale cress (Arabidopsis thaliana) |
eudicotyledons | RAD54 33 |
|
||
rice (Oryza sativa) |
Liliopsida | Os02g0762800 33 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne | |
bread mold (Neurospora crassa) |
Ascomycetes | NCU11255 33 |
|
||
fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp54 33 |
|
||
sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.1041 33 |
|
- Species where no ortholog for RAD54L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RAD54L Gene
(3) SIMAP similar genes for RAD54L Gene using alignment to 4 proteins:
Variants for RAD54L Gene
SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs121908688 | pathogenic, Colonic adenocarcinoma, A colon adenocarcinoma sample | 46,250,097(+) | C/A | 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, missense_variant | |
rs121908689 | pathogenic, Malignant lymphoma, non-Hodgkin, A non-Hodgkin lymphoma sample | 46,272,758(+) | T/A | coding_sequence_variant, missense_variant | |
rs121908690 | pathogenic, Ductal breast carcinoma, A breast cancer sample | 46,267,540(+) | G/A | coding_sequence_variant, missense_variant | |
rs374567435 | likely-pathogenic, Inborn genetic diseases | 46,274,151(+) | C/T | coding_sequence_variant, missense_variant | |
rs797044888 | likely-pathogenic, Inborn genetic diseases | 46,267,600(+) | G/A/T | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2761743 | CNV | gain | 21179565 |
esv3585930 | CNV | gain | 21293372 |
esv3585931 | CNV | gain | 21293372 |
nsv470711 | CNV | gain | 18288195 |
nsv829748 | CNV | loss | 17160897 |
Additional Variant Information for RAD54L Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD54L Gene
Disorders for RAD54L Gene

(9) MalaCards diseases for RAD54L Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
Disorder | Aliases | PubMed IDs |
---|---|---|
lymphoma, non-hodgkin, familial |
|
|
colon adenocarcinoma |
|
|
breast ductal carcinoma |
|
|
appendix adenocarcinoma |
|
|
breast cancer |
|
|
Additional Disease Information for RAD54L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for RAD54L Gene
Publications for RAD54L Gene
- Homologous DNA pairing by human recombination factors Rad51 and Rad54. (PMID: 12205100) Sigurdsson S … Sung P (The Journal of biological chemistry 2002) 3 4 22 58
- The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. (PMID: 11459989) Ristic D … Kanaar R (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 22 58
- Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors. (PMID: 9192813) Rasio D … Croce CM (Cancer research 1997) 3 4 22 58
- Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. (PMID: 8805304) Kanaar R … Hoeijmakers JH (Current biology : CB 1996) 2 3 4 58
- Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PMID: 20496165) Monsees GM … Han J (Breast cancer research and treatment 2011) 3 44 58
Products for RAD54L Gene
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- Invitrogen Antibodies for RAD54L
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD54L
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 69 available RAD54L Antibodies ranked by validation data
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Sources for RAD54L Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
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