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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD54L Gene

protein-coding   GIFtS: 65
GCID: GC01P046713

RAD54-like (S. cerevisiae)

(Previous name: RAD54 (S.cerevisiae)-like )
 Explore 28 diseases affiliated with
RAD54L via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD54L    

Aliases
for RAD54L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAD54-Like (S. Cerevisiae)1 2     RAD54 (S.Cerevisiae)-Like1
RAD54A1 2 3     DNA Repair And Recombination Protein RAD54-Like2
HHR541     EC 3.6.4.-3
HRAD545     HRAD545
RAD54 Homolog2 3     EC 3.6.18
HR542 5     

External Ids:    HGNC: 98261   Entrez Gene: 84382   Ensembl: ENSG000000859997   OMIM: 6036155   UniProtKB: Q926983   

Export aliases for RAD54L gene to outside databases

Previous GC identifers: GC01P046407 GC01P045670 GC01P046099 GC01P046083 GC01P046425 GC01P046485 GC01P044829


Summaries
for RAD54L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD54L:
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with
Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This
protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The
binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate
homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants
encoding the same protein.(provided by RefSeq, Dec 2008)

UniProtKB/Swiss-Prot: RAD54_HUMAN, Q92698
Function: Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52)
pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51
protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere
capping in mammalian cells

Gene Wiki entry for RAD54L (DNA repair and recombination protein RAD54-like)


Genomic Views
for RAD54L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD54L gene promoter:
         STAT1   NF-1/L   NF-1   STAT1beta   CUTL1   STAT1alpha   YY1   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: RAD54L promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD54L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD54L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p34.1   HGNC cytogenetic band: 1p32

RAD54L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD54L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P046713:  view genomic region     (about GC identifiers)

Start:
 46,713,360 bp from pter      End:
 46,744,145 bp from pter
Size:
 30,786 bases      Orientation:
 plus strand

Proteins
for RAD54L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RAD54_HUMAN, Q92698 (See protein sequence)
Recommended Name: DNA repair and recombination protein RAD54-like  
Size: 747 amino acids; 84352 Da
Subunit: Interacts (via N-terminus) with RAD51
Subcellular location: Nucleus
Secondary accessions: Q5TE31 Q6IUY3

Explore the universe of human proteins at neXtProt for RAD54L: NX_Q92698

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92698

    • 4/7 DME Specific Peptides for RAD54L (Q92698) (see all 7)
     MGLGKTL  GTIEEKI  LMWTLLRQ  LRPHQREG 

    RAD54L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136020.1  NP_003570.2  

    ENSEMBL proteins: 
     ENSP00000361043   ENSP00000396113  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): RAD54L
    OriGene Protein Over-expression Lysate (see all 2): RAD54L
    OriGene Custom Protein Services for RAD54L 
    GenScript Custom Purified and Recombinant Proteins Services for RAD54L
    Novus Biologicals RAD54L Protein
    Novus Biologicals RAD54L Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAD54L

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    RAD54L for ontologies           About GeneDecksing



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    Uscn Antibodies for RAD54L
    ThermoFisher Antibodies for RAD54L

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    Uscn ELISAs and CLIAs for RAD54L

    Protein Domains /
    Families
    for RAD54L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD54L for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000330 SNF2_N
     IPR013967 Rad54_N
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q92698

    ProtoNet protein and cluster: Q92698

    1 Blocks protein family: IPB000330 SNF2 related domain

    UniProtKB/Swiss-Prot: RAD54_HUMAN, Q92698
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for RAD54L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RAD54_HUMAN, Q92698
    Function: Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52)
    pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51
    protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere
    capping in mammalian cells
    Induction: Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle

         Genatlas biochemistry entry for RAD54L:
    yeast (S cerevisiae) RAD54 homolog,93kDa,SNF2/SW12 family,highly expressed in organs of germ cells and lymphoid
    development,recombinational protein associated with RAD51,involved in nucleotide excision repair of double-strand
    break and in meiotic recombination,RAD52 epistasis group,localized in a region of high loss of heterozygosity in
    breast cancer,potential tumor suppressor in parathyroid adenomas (see TSG1J) and in breast cancer with poor prognosis

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

    miRNA
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    hsa-miR-3163 hsa-miR-629* hsa-miR-561 hsa-miR-3919 hsa-miR-3925-5p hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmid: RAD54L 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD54L (see all 7)
    OriGene shRNA RFP: RAD54L
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD54L

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAD54L

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD54L (see all 6)
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54L 

    Cell Line
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    Search LifeMap BioReagents cell lines for RAD54L

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0004386helicase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0036310annealing helicase activity IDA--


    RAD54L for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Rad54ltm1Jhjh for RAD54L
         5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rad54l):
     cellular  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    RAD54L for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD54L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiosis
    		Meiosis1.00
    2Integrated Breast Cancer Pathway
    		Integrated Breast Cancer Pathway1.00
    3Homologous recombination
    		Homologous recombination0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAD54L
        Meiosis


    1 BioSystems Pathway for RAD54L 
        Integrated Breast Cancer Pathway


    1         Kegg Pathway  (Kegg details for RAD54L):
        Homologous recombination


    RAD54L for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD54L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/90 Interacting proteins for RAD54L (Q926981, 3 ENSP000003610434) via UniProtKB, MINT, STRING, and/or I2D (see all 90)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51Q066093, ENSP000002678684I2D: score=4 STRING: ENSP00000267868
    FEN1P397483, ENSP000003054804I2D: score=2 STRING: ENSP00000305480
    H3F3AP842433I2D: score=2 
    H3F3BP842433I2D: score=2 
    ASF1AQ9Y2943, ENSP000002295954I2D: score=1 STRING: ENSP00000229595
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IEA--
    GO:0000733DNA strand renaturation IDA--
    GO:0006281DNA repair TAS8805304
    GO:0006302double-strand break repair ----
    GO:0006310DNA recombination TAS8805304


    RAD54L for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD54L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD54L for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD54L
    1 Novoseek chemical compound relationship for RAD54L gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 47.2 9 15466868 (1), 10209103 (1), 12205100 (1), 11884632 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD54L / RAD54 

    Transcripts
    for RAD54L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD54L gene (2 alternative transcripts): 
    NM_001142548.1  NM_003579.3  

    Unigene Cluster for RAD54L:

    RAD54-like (S. cerevisiae)
    Hs.642042  [show with all ESTs]
    Unigene Representative Sequence: NM_003579
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463715 ENST00000493985 ENST00000371975(uc001cpl.2) ENST00000469835
    ENST00000487700 ENST00000493032 ENST00000472889 ENST00000473251 ENST00000476687
    ENST00000488942 ENST00000459678 ENST00000442598(uc009vye.2)

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD54L
    6 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD54L:
    hsa-miR-3163 hsa-miR-629* hsa-miR-561 hsa-miR-3919 hsa-miR-3925-5p hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmid: RAD54L 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD54L (see all 7)
    OriGene shRNA RFP: RAD54L
    OriGene siRNA: RAD54L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD54L
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD54L (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): RAD54L (NM_003579)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54L 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD54L

    Additional cDNA sequence: 

    AK292611.1 AK297204.1 BC121059.1 BC121060.1 X97795.1 

    24/26 DOTS entries (see all 26):

    DT.100880544  DT.99987751  DT.101984839  DT.100871286  DT.455773  DT.95258380  DT.95258338  DT.99954029 
    DT.100880548  DT.102843187  DT.121326417  DT.121326420  DT.121326506  DT.121326364  DT.121326465  DT.40213611 
    DT.404972  DT.91948319  DT.99982975  DT.121326382  DT.91814854  DT.91847320  DT.92452538  DT.95258333 

    24/132 AceView cDNA sequences (see all 132):

    AV656808 BU552753 BG258318 CR594300 AI474694 BU932120 BM773411 BM745768 
    BX333113 BQ225695 BM772100 AW079580 BP338308 BU165801 BU553867 AL520104 
    BX363303 BM720371 BP365372 BF115972 BM825772 BU633988 BU932121 BQ277879 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD54L    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                      
    SP2:                                                                    -                                 
    SP3:                                                                                                      
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for RAD54L

    Expression
    for RAD54L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD54L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGTTTGCCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAD54L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Head MesenchymeBranchial Arch 1Cranial Neural Crest CellsNeural Crest
    BrainHypothalamusBrain
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAD54L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD54L

    SOURCE GeneReport for Unigene cluster: Hs.642042
        SABiosciences Expression via Pathway-Focused PCR Array including RAD54L: 
              DNA Repair in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for RAD54L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD54L gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAD54L1 RAD54-like (S. cerevisiae) 76.34(n)
    85.02(a)    		   424611  XM_422447.2  XP_422447.2 
    lizard
    (Anolis carolinensis)    		 Reptilia RAD54L6
    		 --
    		 85(a)
    		 1 ↔ 1
    		 4(112133075-112147941)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BI442106.12   -- 74.7(n)    BI442106.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc562892 similar to RAD54-like (S. cerevisiae) 76.23(n)   394119  BC046050.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta okr1 , 3 dorsal appendage formation ATP dependent DNA
    helicase3
    okra1    		 54(a)3
    58.16(n)1
    56.34(a)1    		   2 23C43
    335071  NM_057313.41  NP_476661.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y116A8C.133
    rad-541    		 Protein RAD-541 34(a)3
    54.99(n)1
    56.64(a)1    		   IV(16950225-16962960)3
    1727281  NM_060037.31  NP_492438.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RAD54(YGL163C)4
    RAD541    		 DNA-dependent ATPase, stimulates strand exchange by more4
    Rad54p1    		 54.44(n)1
    53.51(a)1    		   7(196403-193707)4
    8527131, 4  NP_011352.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RAD541 Rad54-like protein 53.41(n)
    49.25(a)    		   821455  NM_112808.3  NP_188552.3 
    rice
    (Oryza sativa)    		 Liliopsida Os02g07628001 hypothetical protein 51.9(n)
    46.72(a)    		   4330819  NM_001054742.2  NP_001048207.2 


    ENSEMBL Gene Tree for RAD54L (if available)
    TreeFam Gene Tree for RAD54L (if available) 

    Paralogs
    for RAD54L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD54L gene
    RAD54L22  ATRX2  
    3 SIMAP similar genes for RAD54L using alignment to 2 protein entries:     RAD54_HUMAN (see all proteins):
    DKFZp434J1672    RAD54B    HELLS

    RAD54L for paralogs           About GeneDecksing



    Genomic Variants
    for RAD54L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/521 NCBI SNPs in RAD54L are shown (see all 521)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1136213401,2
    		C,--46711519(+) GTAGAG/AACGGG 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1864670631,2
    		--46711575(+) TGATCC/TGCTGG 2 -- us2k10--------
    rs1917072531,2
    		--46711806(+) TTTTTA/TGTATT 2 -- us2k10--------
    rs1833756831,2
    		--46711809(+) TTTGTA/GTTTTT 2 -- us2k10--------
    rs1117169281,2
    		C,--46711876(+) ATCCGC/TCCGTC 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1909839571,2
    		--46711969(+) CTGTCA/GTCCAG 2 -- us2k10--------
    rs1833944691,2
    		--46712172(+) CCTGCC/GTCGGC 2 -- us2k10--------
    rs1402025321,2
    		--46712403(+) GCCTGC/GTGGTA 2 -- us2k10--------
    rs1385741781,2
    		C,--46712641(+) GCAGC-/TTTCTT 2 -- us2k10--------
    rs728990541,2
    		C,--46712693(+) TCCCAC/TTGCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD54L (46713360 - 46744145 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RAD54L
         2 Indels: 84212 74470
    Human Gene Mutation Database (HGMD): RAD54L

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    Disorders / Diseases
    for RAD54L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD54L for disorders           About GeneDecksing

    OMIM gene information: 603615   
    OMIM disorders: 114480  605027  
    20/28 diseases for RAD54L (see all 28):    About MalaCards
    lymphoma, non-hodgkin, somatic    breast cancer, invasive ductal    xeroderma pigmentosum    adenocarcinoma, colonic, somatic
    severe combined immunodeficiency    familial chronic lymphocytic leukemia    chronic lymphocytic leukemia    bloom syndrome
    combined immunodeficiency    werner syndrome    parathyroid adenoma    lymphocytic leukemia
    breast cancer    multiple sclerosis    oligodendroglioma    immunodeficiency
    pulmonary disease    adenoma    adenocarcinoma    leukemia

    5 Novoseek disease relationships for RAD54L gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bloom syndrome 72.1 2 10640146 (1)
    werner syndrome 68.3 2 10640146 (1)
    allelic imbalance 68.2 2 10640146 (1)
    xeroderma pigmentosum 59 2 10640146 (1)
    tumors 4.24 14 9192813 (2), 10640146 (2), 10326867 (2), 15056673 (1) (see all 5)

    Genetic Association Database (GAD): RAD54L
    Human Genome Epidemiology (HuGE) Navigator: RAD54L (18 documents)

    Export disorders for RAD54L gene to outside databases

    Publications
    for RAD54L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD54L gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with RAD54L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. (PubMed id 8805304)1, 2, 3 Kanaar R.... Hoeijmakers J.H.J. (1996)
    2. Homologous DNA pairing by human recombination factors Rad51 and Rad54. (PubMed id 12205100)1, 2, 9 Sigurdsson S.... Sung P. (2002)
    3. Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors. (PubMed id 9192813)1, 2, 9 Rasio D.... Croce C.M. (1997)
    4. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. (PubMed id 11459989)1, 2, 9 Ristic D.... Kanaar R. (2001)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Implications of a RAD54L polymorphism (2290C/T) in human meningiomas as a risk factor and/or a genetic marker. (PubMed id 12614485)1, 4 Leone P.E....Pestana A. (2003)
    8. Analysis of the RAD54 gene on chromosome 1p as a potential tumor- suppressor gene in parathyroid adenomas. (PubMed id 10449612)1, 2 Carling T.... Arnold A. (1999)
    9. Mutations in the RAD54 recombination gene in primary cancers. (PubMed id 10362365)1, 2 Matsuda M....Kamiya K. (1999)
    10. The human RAD54 recombinational DNA repair protein is a double- stranded DNA-dependent ATPase. (PubMed id 9774452)1, 2 Swagemakers S.M.A....Kanaar R. (1998)

    External Searches for RAD54L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD54L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8438 HGNC: 9826 AceView: RAD54L Ensembl:ENSG00000085999 euGenes: HUgn8438
    ECgene: RAD54L Kegg: 8438 H-InvDB: RAD54L

    Other Databases showing RAD54L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD54L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD54L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD54L Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad54l/

    Intellectual Property
    for RAD54L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD54L gene:
    Search GeneIP for patents involving RAD54L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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