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Aliases for RAD54L Gene

Aliases for RAD54L Gene

  • RAD54-Like (S. Cerevisiae) 2 3 5
  • RAD54 Homolog 3 4
  • RAD54A 3 4
  • HRAD54 3 4
  • HHR54 3 4
  • RAD54 (S.Cerevisiae)-Like 2
  • EC 3.6.4.- 4
  • EC 3.6.1 63
  • HR54 3

External Ids for RAD54L Gene

Previous GeneCards Identifiers for RAD54L Gene

  • GC01P046407
  • GC01P045670
  • GC01P046099
  • GC01P046083
  • GC01P046425
  • GC01P046485
  • GC01P046713
  • GC01P044829

Summaries for RAD54L Gene

Entrez Gene Summary for RAD54L Gene

  • The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

GeneCards Summary for RAD54L Gene

RAD54L (RAD54-Like (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RAD54L include lymphoma, non-hodgkin and breast cancer. Among its related pathways are Integrated Breast Cancer Pathway and Homologous recombination. GO annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is ATRX.

UniProtKB/Swiss-Prot for RAD54L Gene

  • Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.

Gene Wiki entry for RAD54L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD54L Gene

Genomics for RAD54L Gene

Regulatory Elements for RAD54L Gene

Promoters for RAD54L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAD54L on UCSC Golden Path with GeneCards custom track

Genomic Location for RAD54L Gene

Chromosome:
1
Start:
46,247,688 bp from pter
End:
46,278,473 bp from pter
Size:
30,786 bases
Orientation:
Plus strand

Genomic View for RAD54L Gene

Genes around RAD54L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD54L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD54L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD54L Gene

Proteins for RAD54L Gene

  • Protein details for RAD54L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92698-RAD54_HUMAN
    Recommended name:
    DNA repair and recombination protein RAD54-like
    Protein Accession:
    Q92698
    Secondary Accessions:
    • Q5TE31
    • Q6IUY3

    Protein attributes for RAD54L Gene

    Size:
    747 amino acids
    Molecular mass:
    84352 Da
    Quaternary structure:
    • Interacts (via N-terminus) with RAD51.

neXtProt entry for RAD54L Gene

Proteomics data for RAD54L Gene at MOPED

Selected DME Specific Peptides for RAD54L Gene

Post-translational modifications for RAD54L Gene

  • Ubiquitination at Lys 302
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for RAD54L (RAD54L)

Domains & Families for RAD54L Gene

Protein Domains for RAD54L Gene

Suggested Antigen Peptide Sequences for RAD54L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92698

UniProtKB/Swiss-Prot:

RAD54_HUMAN :
  • Contains 1 helicase ATP-binding domain.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with RAD54L: view

No data available for Gene Families for RAD54L Gene

Function for RAD54L Gene

Molecular function for RAD54L Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) RAD54 homolog,93kDa,SNF2/SW12 family,highly expressed in organs of germ cells and lymphoid development,recombinational protein associated with RAD51,involved in nucleotide excision repair of double-strand break and in meiotic recombination,RAD52 epistasis group,localized in a region of high loss of heterozygosity in breast cancer,potential tumor suppressor in parathyroid adenomas (see TSG1J) and in breast cancer with poor prognosis
UniProtKB/Swiss-Prot Function:
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
UniProtKB/Swiss-Prot Induction:
Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle.

Enzyme Numbers (IUBMB) for RAD54L Gene

Gene Ontology (GO) - Molecular Function for RAD54L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005524 ATP binding IEA --
GO:0016817 hydrolase activity, acting on acid anhydrides IEA --
genes like me logo Genes that share ontologies with RAD54L: view
genes like me logo Genes that share phenotypes with RAD54L: view

Human Phenotype Ontology for RAD54L Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RAD54L Gene

MGI Knock Outs for RAD54L:

Animal Model Products

CRISPR Products

miRNA for RAD54L Gene

miRTarBase miRNAs that target RAD54L

No data available for Transcription Factor Targets and HOMER Transcription for RAD54L Gene

Localization for RAD54L Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD54L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD54L Gene COMPARTMENTS Subcellular localization image for RAD54L gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for RAD54L Gene

Pathways & Interactions for RAD54L Gene

genes like me logo Genes that share pathways with RAD54L: view

Pathways by source for RAD54L Gene

1 BioSystems pathway for RAD54L Gene
1 KEGG pathway for RAD54L Gene

Gene Ontology (GO) - Biological Process for RAD54L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000733 DNA strand renaturation IDA 22705370
GO:0006281 DNA repair TAS 8805304
GO:0006310 DNA recombination TAS 8805304
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0008340 determination of adult lifespan IEA --
genes like me logo Genes that share ontologies with RAD54L: view

No data available for SIGNOR curated interactions for RAD54L Gene

Drugs & Compounds for RAD54L Gene

(1) Drugs for RAD54L Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RAD54L: view

Transcripts for RAD54L Gene

Unigene Clusters for RAD54L Gene

RAD54-like (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD54L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for RAD54L Gene

GeneLoc Exon Structure for
RAD54L
ECgene alternative splicing isoforms for
RAD54L

Expression for RAD54L Gene

mRNA expression in normal human tissues for RAD54L Gene

mRNA differential expression in normal tissues according to GTEx for RAD54L Gene

This gene is overexpressed in Testis (x6.9).

Protein differential expression in normal tissues from HIPED for RAD54L Gene

This gene is overexpressed in Cerebrospinal fluid (35.2), Neutrophil (15.3), Colon (7.2), and Synovial fluid (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD54L Gene



SOURCE GeneReport for Unigene cluster for RAD54L Gene Hs.642042

genes like me logo Genes that share expression patterns with RAD54L: view

Protein tissue co-expression partners for RAD54L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for RAD54L Gene

Orthologs for RAD54L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD54L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD54L 36
  • 100 (a)
OneToOne
RAD54L 35
  • 99.64 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia RAD54L 35
  • 91.33 (n)
  • 94.5 (a)
RAD54L 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD54L 36
  • 95 (a)
OneToOne
RAD54L 35
  • 91.42 (n)
  • 94.91 (a)
mouse
(Mus musculus)
Mammalia Rad54l 16
Rad54l 35
  • 89.54 (n)
  • 94.5 (a)
Rad54l 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD54L 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD54L 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad54l 35
  • 88.2 (n)
  • 93.83 (a)
chicken
(Gallus gallus)
Aves RAD54L 35
  • 76.34 (n)
  • 85.02 (a)
RAD54L 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD54L 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad54l 35
  • 73.41 (n)
  • 83.54 (a)
zebrafish
(Danio rerio)
Actinopterygii rad54l 36
  • 80 (a)
OneToOne
rad54l 35
  • 72 (n)
  • 80.6 (a)
zgc56289 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008748 35
  • 61.01 (n)
  • 62.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta okr 35
  • 58.02 (n)
  • 55.98 (a)
okr 37
  • 54 (a)
okr 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.13 37
  • 34 (a)
rad-54 35
  • 56.84 (n)
  • 59.43 (a)
rad-54 36
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL297W 35
  • 53.51 (n)
  • 51.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD54 35
  • 54.26 (n)
  • 53.13 (a)
RAD54 36
  • 39 (a)
OneToMany
RAD54 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03069g 35
  • 53.12 (n)
  • 52.45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD54 35
  • 53.41 (n)
  • 49.25 (a)
rice
(Oryza sativa)
Liliopsida Os02g0762800 35
  • 54.37 (n)
  • 50.2 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU11255 35
  • 57.38 (n)
  • 57.65 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp54 35
  • 54.81 (n)
  • 55.68 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1041 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for RAD54L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD54L Gene

ENSEMBL:
Gene Tree for RAD54L (if available)
TreeFam:
Gene Tree for RAD54L (if available)

Paralogs for RAD54L Gene

Paralogs for RAD54L Gene

(3) SIMAP similar genes for RAD54L Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAD54L: view

Variants for RAD54L Gene

Sequence variations from dbSNP and Humsavar for RAD54L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_019559 A colon adenocarcinoma sample
rs2295466 - 46,260,585(+) TCAGT(A/G)AGGTT intron-variant, reference, missense, utr-variant-5-prime
VAR_019561 A breast cancer sample
VAR_019562 A non-Hodgkin lymphoma sample
rs28363192 - 46,248,570(+) CTGTG(A/G)TGATG reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for RAD54L Gene

Variant ID Type Subtype PubMed ID
nsv470711 CNV Gain 18288195
nsv829748 CNV Loss 17160897

Variation tolerance for RAD54L Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.88; 48.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD54L Gene

HapMap Linkage Disequilibrium report
RAD54L
Human Gene Mutation Database (HGMD)
RAD54L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD54L Gene

Disorders for RAD54L Gene

MalaCards: The human disease database

(7) MalaCards diseases for RAD54L Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lymphoma, non-hodgkin
  • lymphoma, non-hodgkin, somatic
breast cancer
  • breast cancer, invasive ductal
choroid plexus cancer
  • choroid plexus neoplasm
familial breast cancer
  • breast cancer, familial
cerebral ventricle cancer
  • cerebral ventricle neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for RAD54L

Genetic Association Database (GAD)
RAD54L
Human Genome Epidemiology (HuGE) Navigator
RAD54L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD54L
genes like me logo Genes that share disorders with RAD54L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAD54L Gene

Publications for RAD54L Gene

  1. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. (PMID: 8805304) Kanaar R. … Hoeijmakers J.H.J. (Curr. Biol. 1996) 2 3 4 67
  2. Interactions of human rad54 protein with branched DNA molecules. (PMID: 17545145) Mazina O.M. … Mazin A.V. (J. Biol. Chem. 2007) 3 23
  3. Homologous DNA pairing by human recombination factors Rad51 and Rad54. (PMID: 12205100) Sigurdsson S. … Sung P. (J. Biol. Chem. 2002) 3 23
  4. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. (PMID: 11459989) Ristic D. … Kanaar R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23
  5. hRAD54 gene and 1p high-resolution deletion-mapping analyses in oligodendrogliomas. (PMID: 10640146) Bello M.J. … Rey J.A. (Cancer Genet. Cytogenet. 2000) 3 23

Products for RAD54L Gene

Sources for RAD54L Gene

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