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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

RAD54B Gene

protein-coding GIFtS: 63
GCID: GC08M095384

RAD54 Homolog B (S. Cerevisiae)

Microbiology & Infectious Diseases Congress

14 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
RAD54 Homolog B (S. Cerevisiae)¹ ²
RDH54²
DNA Repair And Recombination Protein RAD54B²
EC 3.6.4.-³
RAD54 Homolog B³
EC 3.6.1⁸

External Ids:	HGNC: 17228¹	Entrez Gene: 25788²	Ensembl: ENSG00000197275⁷	OMIM: 604289⁵	UniProtKB: Q9Y620³

Export aliases for RAD54B gene to outside databases

Previous GC identifers: GC08M094130 GC08M095230 GC08M095052 GC08M095340 GC08M095453 GC08M090593

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD54B Gene:

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with

Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of

DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is

highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination.

Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. (provided by RefSeq, Jul

2008)

GeneCards Summary for RAD54B Gene:

RAD54B (RAD54 homolog B (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD54B include hereditary pancreatitis, and colon cancer, and among its related super-pathways are Homologous recombination. GO annotations related to this gene include DNA helicase activity and DNA translocase activity.

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in

concert with other members of the RAD52 epistasis group

Gene Wiki entry for RAD54B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.2 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the RAD54B gene promoter:
Pbx1a AML1a MEF-2 Evi-1 GATA-1 MEF-2A POU2F1a FOXJ2 (long isoform) FOXJ2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAD54B promoter sequence

Search SABiosciences Chromatin IP Primers for RAD54B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD54B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1

RAD54B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD54B gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M095384: view genomic region (about GC identifiers)

Start:	95,384,188 bp from pter	End:	95,487,343 bp from pter
Size:	103,156 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620 (See protein sequence)

Recommended Name: DNA repair and recombination protein RAD54B

Size: 910 amino acids; 102967 Da

Subunit: Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the

interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect

Subcellular location: Nucleus (Probable)

Secondary accessions: F6WBS8

Alternative splicing: 2 isoforms: Q9Y620-1 Q9Y620-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD54B: NX_Q9Y620

Explore proteomics data for RAD54B at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9Y620

4/7 DME Specific Peptides for RAD54B (Q9Y620) (see all 7)

GGVGLNL

MGLGKTL

IYRLLTT

GTIEEKI

RAD54B Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (3 alternative transcripts):

NP_001192191.1 NP_001192192.1 NP_036547.1

ENSEMBL proteins:

ENSP00000336606 ENSP00000430808 ENSP00000430570 ENSP00000428554 ENSP00000430153

Human Recombinant Protein Products for RAD54B:

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	GenScript Custom Purified and Recombinant Proteins Services for RAD54B
	Novus Biologicals RAD54B Proteins Novus Biologicals RAD54B Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

RAD54B for ontologies About GeneDecksing

RAD54B Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD54B
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Assay Products for RAD54B:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

4 InterPro protein domains:

IPR000330 SNF2_N

IPR027417 P-loop_NTPase

IPR014001 Helicase_ATP-bd

IPR001650 Helicase_C

Graphical View of Domain Structure for InterPro Entry Q9Y620

ProtoNet protein and cluster: Q9Y620

1 Blocks protein domain: IPB000330 SNF2 related domain

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Similarity: Belongs to the SNF2/RAD54 helicase family

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

RAD54B for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: RA54B_HUMAN, Q9Y620

Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in

concert with other members of the RAD52 epistasis group

Genatlas biochemistry entry for RAD54B:

yeast (S cerevisiae) RAD54 homolog,recombination gene,highly expressed in testis and spleen,homozygously mutated

in primary lymphoma and colon cancer

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.-¹

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003678	DNA helicase activity	TAS	10362364
GO:0003724	RNA helicase activity	TAS	10362364
GO:0004386	helicase activity	--	--

RAD54B for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rad54b):

cellular

hematopoietic system

homeostasis/metabolism

mortality/aging

RAD54B for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Rad54b^tm1Roka for RAD54B

inGenious Targeting Laboratory - Custom generated mouse model solutions for RAD54B

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAD54B

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD54B

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD54B

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD54B
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD54B:
		hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
		SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for RAD54B
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for RAD54B (see all 4) OriGene ORF clones in mouse, rat for RAD54B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RAD54B (NM_001205262)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAD54B
		Search LifeMap BioReagents cell lines for RAD54B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for RAD54B About

See pathways by source

SuperPath

Contained pathways About

Homologous recombination

Homologous recombination

0.40

Homologous recombination

0.40

Meiosis

Meiosis

Pathways by source See SuperPaths
Show all pathways

1 EMD Millipore Pathway for RAD54B

Meiosis

1 BioSystems Pathway for RAD54B

Homologous recombination

1 Kegg Pathway (Kegg details for RAD54B):

Homologous recombination

RAD54B for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for RAD54B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/44 Interacting proteins for RAD54B (Q9Y620^{2, 3} ENSP00000336606⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CSNK1E	P49674²^,³, ENSP00000352929⁴	MINT-67588 I2D: score=5 STRING: ENSP00000352929
DYRK2	Q92630²^,³, ENSP00000342105⁴	MINT-67527 I2D: score=5 STRING: ENSP00000342105
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-68231 I2D: score=5 STRING: ENSP00000263925
TRAPPC6A	O75865²^,³, ENSP00000006275⁴	MINT-67956 I2D: score=5 STRING: ENSP00000006275
PSMA1	P25786²^,³	MINT-67096 I2D: score=5

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	IDA	16428451
GO:0006312	mitotic recombination	TAS	10362364
GO:0007131	reciprocal meiotic recombination	TAS	10362364
GO:0032508	DNA duplex unwinding	TAS	10362364

RAD54B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for RAD54B (RA54B)

Search CenterWatch for drugs/clinical trials and news about RAD54B / RA54B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for RAD54B gene (5 alternative transcripts):

NM_001205262.2 NM_001205263.1 NM_012415.3 NM_006550.1 NM_134434.1

Unigene Cluster for RAD54B:

RAD54 homolog B (S. cerevisiae)

Hs.744229 [show with all ESTs]

Unigene Representative Sequence: NM_001205262

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336148(uc010may.2 uc003ygk.3 uc003ygl.2) ENST00000519348

ENST00000518358 ENST00000463267 ENST00000523192 ENST00000518998 ENST00000523839

ENST00000297592(uc003ygn.2)

Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA Products:		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD54B
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD54B:
		hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
		SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Clone Products:		OriGene clones in human, mouse for RAD54B (see all 4) OriGene ORF clones in mouse, rat for RAD54B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RAD54B (NM_001205262)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54B
		Sirion Biotech Customized lentivirus for stable overexpression of RAD54B Customized lentivirus expression plasmids for stable overexpression of RAD54B

Primer Products:		OriGene qPCR primer pairs and template standards for RAD54B OriGene qSTAR qPCR primer pairs in human, mouse for RAD54B
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat RAD54B
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD54B
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD54B

Additional mRNA sequence:

AF086020.1 AF112481.1 AK290437.1 AK307516.1 AL133578.1 BC001965.2 BC020668.1 BC033710.2

10 DOTS entries:

DT.306247 DT.105675 DT.91939615 DT.102836258 DT.121478779 DT.121478780 DT.121478762 DT.121478774

DT.92422333 DT.97824274

24/70 AceView cDNA sequences (see all 70):

BC020668 BE888572 AF112481 BC033710 AA973748 BX955743 H88371 AW151987

BC001965 AF007866 NM_006550 BM930136 AL523600 NM_012415 BU538087 CR602319

H88433 BX955752 NM_134434 AF086020 BU956980 BX283391 CB145803 BF697708

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAD54B (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:											-												-
SP2:									-		-
SP3:
SP4:
SP5:																																	-

ECgene alternative splicing isoforms for RAD54B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

RAD54B expression in normal human tissues (normalized intensities) RAD54B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

RAD54B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/16 selected tissues (see all 16) fully expand


Brain (Nervous System) fully expand to see all 8 entries
Adult Endothelial Cells Blood Brain Barrier
Thalamus
brain/midbrain

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Eye (Sensory Organs)
Retina

Thymus (Hematopoietic System)
Thymus

Gut Tube (Gastrointestinal Tract)
Foregut

See RAD54B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAD54B

SOURCE GeneReport for Unigene cluster: Hs.744229

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Tissue specificity: Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate,

ovary and colon

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD54B

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD54B gene from 7/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rad54b^{1 , 5}	RAD54 homolog B (S. cerevisiae)^{1, 5}	83.03(n)¹ 80.61(a)¹		4 (5.11 cM)⁵ 623474¹ NM_001039556.3¹ NP_001034645.1¹ 11558922⁵
chicken (Gallus gallus)	Aves	RAD54B¹	RAD54 homolog B (S. cerevisiae)	72.12(n) 70.24(a)		395449 NM_204710.1 NP_990041.1
lizard (Anolis carolinensis)	Reptilia	RAD54B⁶	Uncharacterized protein	71(a)	1 ↔ 1	4(18975516-19014898)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32066²	Xenopus laevis transcribed sequence with weak similarity more	75.95(n)		BJ627295.1
zebrafish (Danio rerio)	Actinopterygii	rad54b¹	RAD54 homolog B (S. cerevisiae)	58.42(n) 58.83(a)		560482 XM_683887.5 XP_688979.3
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP006945¹	AGAP006945-PA	48.55(n) 46.04(a)		1270139 XM_308811.4 XP_308811.4
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RDH54(YBR073W)⁴ RDH54¹	DNA-dependent ATPase, stimulates strand exchange by more⁴ Rdh54p¹	48.89(n)¹ 43(a)¹		2(383112-385988)⁴ 852365^{1, 4} NP_009629.6¹ NP_009629.2⁴

ENSEMBL Gene Tree for RAD54B (if available)
TreeFam Gene Tree for RAD54B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for RAD54B gene

2 SIMAP similar genes for RAD54B using alignment to 4 protein entries: RA54B_HUMAN (see all proteins):

DKFZp434J1672 RAD54L

RAD54B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
VAR_019563⁴		A colon cancer sample⁴	--	see VAR_019563	2	D Y	mis⁴		0	--	--	--	--
rs114216685^1,2,4	C,F	A non-Hodgkin lymphoma sample⁴ pathogenic¹	95560378(+)	`GGTGAT/CTGCAC`	4	/N /S	mis¹		3		EA NA	640
rs35880440^1,2	C	--	90625080(+)	`GCAGT-/ATGTTTG`	2	--	int¹		0	--	--	--	--
rs13439554^1,2	A	--	90643779(+)	`aaaaaA/Tatata`	2	--	int¹ trp³		0	--	--	--	--
rs137936104^1,2	C	--	90670210(+)	`GCATG-/CA /CACACACAC`	2	--	int¹		0	--	--	--	--
rs34711293^1,2	C	--	95385638(+)	`TGGCC-/TTATGG`	2	--	int¹		2		NA CSA	4
rs59955111^1,2	C	--	95390204(+)	`AAAAA-/AAAGATTC`	2	--	int¹		1		NA	2
rs35744651^1,2	C	--	95393356(+)	`CTTTT-/AAAAAA`	2	--	int¹		1		NA	2
rs35352826^1,2	C	--	95396441(+)	`GCAAC-/ATTATT`	2	--	int¹		1		NA	2
rs11273608^1,2	C	--	95396749(+)	`TAGAT-/TTCAGTTTTGT TTGCAAAACTGAAATAGT`	2	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for RAD54B (95384188 - 95487343 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RAD54B: About this table

Variant ID	Type	Subtype	PubMed ID
nsv6313	CNV	Insertion	18451855
nsv891202	CNV	Loss	21882294
nsv831401	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): RAD54B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604289 OMIM disorders: --

14 diseases for RAD54B: About MalaCards

hereditary pancreatitis colon cancer nijmegen breakage syndrome werner syndrome

cervical cancer pneumonia pancreatitis multiple sclerosis

pancreatic cancer cervicitis tuberculosis colorectal cancer

breast cancer prostatitis

RAD54B for disorders About GeneDecksing

1 Novoseek inferred disease relationship for RAD54B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	15056673 (1)

Genetic Association Database (GAD): RAD54B
Human Genome Epidemiology (HuGE) Navigator: RAD54B (10 documents)

Export disorders for RAD54B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAD54B gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with RAD54B)

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Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. (PubMed id 10362364)^{1, 2, 3, 9} Hiramoto T.... Kamiya K. (1999)
A novel human rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)^{1, 2, 3, 9} Tanaka K....Miyagawa K. (2000)
Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. (PubMed id 11884632)^{1, 2, 9} Tanaka K.... Miyagawa K. (2002)
Gamma-radiation sensitivity and polymorphisms in RAD5 1L1 modulate glioma risk. (PubMed id 20610542)^{1, 4} Liu Y....Bondy M.L. (2010)
Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)^{1, 4} Briggs F.B....Barcellos L.F. (2010)
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)^{1, 4} McWilliams R.R....Petersen G.M. (2009)
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)^{1, 4} Mavaddat N....Pharoah P.D. (2009)
Explorative study to identify novel candidate genes r elated to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)^{1, 4} Kweekel D.M....Guchelaar H.J. (2009)
Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer. (PubMed id 19012493)^{1, 4} Wang S.S....Hildesheim A. (2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25788	HGNC: 17228	AceView: FSBP	Ensembl:ENSG00000197275	euGenes: HUgn25788
ECgene: RAD54B	Kegg: 25788	H-InvDB: RAD54B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for RAD54B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAD54B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAD54B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RAD54B gene:
Search GeneIP for patents involving RAD54B

GeneCards and IP:
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RAD54B Gene

RAD54 Homolog B (S. Cerevisiae)

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RAD54B Gene

RAD54 Homolog B (S. Cerevisiae)

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