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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD54B Gene

protein-coding   GIFtS: 62
GCID: GC08M095384

RAD54 homolog B (S. cerevisiae)
 Explore 18 diseases affiliated with
RAD54B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD54B    

Aliases
for RAD54B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAD54 Homolog B (S. Cerevisiae)1 2
RDH541 2
DNA Repair And Recombination Protein RAD54B2
EC 3.6.4.-3
RAD54 Homolog B3
EC 3.6.18

External Ids:    HGNC: 172281   Entrez Gene: 257882   Ensembl: ENSG000001972757   OMIM: 6042895   UniProtKB: Q9Y6203   

Export aliases for RAD54B gene to outside databases

Previous GC identifers: GC08M094130 GC08M095230 GC08M095052 GC08M095340 GC08M095453 GC08M090593


Summaries
for RAD54B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD54B:
The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces
cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein
binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in
testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene
were observed in primary lymphoma and colon cancer. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620
Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in
concert with other members of the RAD52 epistasis group

Gene Wiki entry for RAD54B


Genomic Views
for RAD54B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008046.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD54B gene promoter:
         Pbx1a   AML1a   MEF-2   Evi-1   GATA-1   MEF-2A   POU2F1a   FOXJ2 (long isoform)   FOXJ2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAD54B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD54B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD54B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

RAD54B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD54B gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095384:  view genomic region     (about GC identifiers)

Start:
 95,384,188 bp from pter      End:
 95,487,337 bp from pter
Size:
 103,150 bases      Orientation:
 minus strand

Proteins
for RAD54B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620 (See protein sequence)
Recommended Name: DNA repair and recombination protein RAD54B  
Size: 910 amino acids; 102967 Da
Subunit: Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the
interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect
Subcellular location: Nucleus (Probable)
Secondary accessions: F6WBS8
Alternative splicing: 2 isoforms:  Q9Y620-1   Q9Y620-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD54B: NX_Q9Y620

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y620

    • 4/7 DME Specific Peptides for RAD54B (Q9Y620) (see all 7)
     GGVGLNL  MGLGKTL  IYRLLTT  GTIEEKI 

    RAD54B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001192191.1  NP_001192192.1  NP_036547.1  

    ENSEMBL proteins: 
     ENSP00000336606   ENSP00000430808   ENSP00000430570   ENSP00000428554   ENSP00000430153  

    Human Recombinant Protein Products: 
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals RAD54B Proteins
    Novus Biologicals RAD54B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    RAD54B for ontologies           About GeneDecksing



    RAD54B Antibody Products: 
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    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for RAD54B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD54B for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR000330 SNF2_N
     IPR014001 Helicase_ATP-bd
     IPR001650 Helicase_C

    Graphical View of Domain Structure for InterPro Entry Q9Y620

    ProtoNet protein and cluster: Q9Y620

    1 Blocks protein family: IPB000330 SNF2 related domain

    UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620
    Similarity: Belongs to the SNF2/RAD54 helicase family
    Similarity: Contains 1 helicase ATP-binding domain
    Similarity: Contains 1 helicase C-terminal domain


    Function
    for RAD54B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620
    Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in
    concert with other members of the RAD52 epistasis group

         Genatlas biochemistry entry for RAD54B:
    yeast (S cerevisiae) RAD54 homolog,recombination gene,highly expressed in testis and spleen,homozygously mutated in
    primary lymphoma and colon cancer

    Enzyme Numbers (IUBMB): EC 3.6.12 EC 3.6.4.-1

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD54B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD54B:
    hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54B 

    Cell Line
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    Search LifeMap BioReagents cell lines for RAD54B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003678DNA helicase activity TAS10362364
    GO:0003724RNA helicase activity TAS10362364
    GO:0005524ATP binding IEA--
    GO:0015616DNA translocase activity IDA16428451


    RAD54B for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Rad54btm1Roka for RAD54B
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rad54b):
     cellular  hematopoietic system  homeostasis/metabolism  mortality/aging 

    RAD54B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD54B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Homologous recombination
    		Homologous recombination1.00
    		Homologous recombination0.38
    2Meiosis
    		Meiosis1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAD54B
        Meiosis


    1 BioSystems Pathway for RAD54B 
        Homologous recombination


    1         Kegg Pathway  (Kegg details for RAD54B):
        Homologous recombination


    RAD54B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD54B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for RAD54B (Q9Y6202, 3 ENSP000003366064) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO15BQ96JP22, 3, ENSP000002932014MINT-67305 I2D: score=1 STRING: ENSP00000293201
    CSNK1EP496742, 3, ENSP000003529294MINT-67588 I2D: score=5 STRING: ENSP00000352929
    DYRK2Q926302, 3, ENSP000003421054MINT-67527 I2D: score=5 STRING: ENSP00000342105
    LNX1Q8TBB12, 3, ENSP000002639254MINT-68231 I2D: score=5 STRING: ENSP00000263925
    TRAPPC6AO758652, 3, ENSP000000062754MINT-67956 I2D: score=5 STRING: ENSP00000006275
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IDA16428451
    GO:0006312mitotic recombination TAS10362364
    GO:0007131reciprocal meiotic recombination TAS10362364
    GO:0010212response to ionizing radiation ----
    GO:0032508DNA duplex unwinding TAS10362364


    RAD54B for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD54B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD54B
    Search CenterWatch for drugs/clinical trials and news about RAD54B / RA54B 

    Transcripts
    for RAD54B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD54B gene (5 alternative transcripts): 
    NM_001205262.2  NM_001205263.1  NM_012415.3  NM_006550.1  NM_134434.1  

    Unigene Cluster for RAD54B:

    RAD54 homolog B (S. cerevisiae)
    Hs.744229  [show with all ESTs]
    Unigene Representative Sequence: NM_001205262
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336148(uc010may.2 uc003ygk.3 uc003ygl.2) ENST00000519348
    ENST00000518358 ENST00000463267 ENST00000523192 ENST00000518998 ENST00000523839
    ENST00000297592(uc003ygn.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD54B
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD54B:
    hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
    SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD54B
    OriGene shRNA RFP: RAD54B
    OriGene siRNA: RAD54B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD54B
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): RAD54B (NM_001205262)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD54B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD54B

    Additional cDNA sequence: 

    AF086020.1 AF112481.1 AK290437.1 AK307516.1 AL133578.1 BC001965.2 BC020668.1 BC033710.2 

    10 DOTS entries:

    DT.306247  DT.105675  DT.91939615  DT.102836258  DT.121478779  DT.121478780  DT.121478762  DT.121478774 
    DT.92422333  DT.97824274 

    24/70 AceView cDNA sequences (see all 70):

    H88371 BX955743 BM930136 BC033710 AW151987 NM_006550 BX283391 BE888572 
    CB145803 AF112481 H88433 NM_012415 AL523600 BU538087 BX955752 CR602319 
    BC001965 AA973748 BU956980 AF086020 NM_134434 AF007866 BC020668 BM746093 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for RAD54B (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
    SP1:                                -                                   -                                                   
    SP2:                          -     -                                                                                       
    SP3:                                                                                                                        
    SP4:                                                                                                                        
    SP5:                                                                                                  -                     


    ECgene alternative splicing isoforms for RAD54B

    Expression
    for RAD54B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD54B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAD54B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    TestisTestis CordXY Germ CellsGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAD54B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD54B

    SOURCE GeneReport for Unigene cluster: Hs.744229

    UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620
    Tissue specificity: Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate,
    ovary and colon

        SABiosciences Custom PCR Arrays for RAD54B
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

    Orthologs
    for RAD54B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAD54B gene from 7/28 species (see all 28)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAD54B1 RAD54 homolog B (S. cerevisiae) 72.12(n)
    70.24(a)    		   395449  NM_204710.1  NP_990041.1 
    lizard
    (Anolis carolinensis)    		 Reptilia RAD54B6
    		 --
    		 71(a)
    		 1 ↔ 1
    		 4(18975516-18992436)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.320662 Xenopus laevis transcribed sequence with weak similarity more 75.95(n)    BJ627295.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rad54b1 RAD54 homolog B (S. cerevisiae) 58.42(n)
    58.83(a)    		   560482  XM_683887.5  XP_688979.3 
    mosquito
    (Anopheles gambiae)    		 Insecta AgaP_AGAP0069451 AGAP006945-PA 48.55(n)
    46.04(a)    		   1270139  XM_308811.4  XP_308811.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea Y116A8C.133   -- 41(a)   IV(16950225-16962960)   --
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RDH54(YBR073W)4
    RDH541    		 DNA-dependent ATPase, stimulates strand exchange by more4
    Rdh54p1    		 48.89(n)1
    43(a)1    		   2(383112-385988)4
    8523651, 4  NP_009629.61  NP_009629.24 


    ENSEMBL Gene Tree for RAD54B (if available)
    TreeFam Gene Tree for RAD54B (if available) 

    Paralogs
    for RAD54B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for RAD54B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1670 NCBI SNPs in RAD54B are shown (see all 1670)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 8 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1142166851,2
    		C,F,pathogenic90612842(+) GGTGAT/CTGCAC 4 /N /S mis13Minor allele frequency- C:0.02EA NA 640
    rs1135389481,2
    		C,--90592732(+) CACTGC/GGCACA 2 -- ds50012Minor allele frequency- G:0.07NA 122
    rs285747931,2
    		F,--90593695(+) TTTATG/AATAAT 2 -- int11Minor allele frequency- A:0.02WA 118
    rs101119591,2
    		C,F,H,--90593827(+) AAGAAA/TCACAG 2 -- int16Minor allele frequency- T:0.02NS EA NA 538
    rs732701451,2
    		C,--90593883(+) ATACAT/ATAAAT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs1118648291,2
    		F--90594049(+) CAAAAC/TGGGTT 2 -- int12Minor allele frequency- T:0.50CSA 4
    rs768328741,2
    		F,--90594208(+) GAGGTG/AAGGGT 2 -- int11Minor allele frequency- A:0.50NA 4
    rs797828721,2
    		C,--90594702(+) AACAAT/GTTTCT 2 -- int12Minor allele frequency- G:0.07NA 122
    rs726726811,2
    		C,F,--90594717(+) TATCTC/TTTCTC 2 -- int11Minor allele frequency- T:0.03NA 120
    rs801624101,2
    		C,--90595143(+) ACCTAA/GAAGAA 2 -- int12Minor allele frequency- G:0.08NA 122

    HapMap Linkage Disequilibrium report for RAD54B (95384188 - 95487337 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for RAD54B
         1 CNV: 95569
         1 Indel: 82687
    Human Gene Mutation Database (HGMD): RAD54B

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    Disorders / Diseases
    for RAD54B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD54B for disorders           About GeneDecksing

    OMIM gene information: 604289    OMIM disorders: --

    18 diseases for RAD54B:    About MalaCards
    colon cancer    nijmegen breakage syndrome    werner syndrome    hereditary pancreatitis
    multiple sclerosis    cervical cancer    cervicitis    pancreatitis
    pancreatic cancer    breast carcinoma    colorectal cancer    breast cancer
    pneumonia    tuberculosis    carcinoma    malaria
    prostatitis    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for RAD54B:
    Nijmegen breakage syndrome

    1 Novoseek disease relationship for RAD54B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 15056673 (1)

    Human Genome Epidemiology (HuGE) Navigator: RAD54B (10 documents)

    Export disorders for RAD54B gene to outside databases

    Publications
    for RAD54B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD54B gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with RAD54B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. (PubMed id 10362364)1, 2, 3, 9 Hiramoto T.... Kamiya K. (1999)
    2. A novel human rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)1, 2, 3, 9 Tanaka K....Miyagawa K. (2000)
    3. Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. (PubMed id 11884632)1, 2, 9 Tanaka K.... Miyagawa K. (2002)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. A role for RAD54B in homologous recombination in human cells. (PubMed id 11782437)1, 2 Miyagawa K.... Tanaka K. (2002)
    6. [Analysis of loss of heterozygosity and microsatellite instability RAD52, RAD54 and RAD54B gene and BRCA1 gene mutation in breast cancer] (PubMed id 17405295)1, 9 Romanowicz-Makowska H. and Smolarz B. (2006)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Gamma-radiation sensitivity and polymorphisms in RAD5 1L1 modulate glioma risk. (PubMed id 20610542)1 Liu Y....Bondy M.L. (2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)

    External Searches for RAD54B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD54B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25788 HGNC: 17228 AceView: FSBP Ensembl:ENSG00000197275 euGenes: HUgn25788
    ECgene: RAD54B Kegg: 25788 H-InvDB: RAD54B

    Other Databases showing RAD54B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD54B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD54B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD54B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for RAD54B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD54B gene:
    Search GeneIP for patents involving RAD54B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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