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RAD54B Gene

protein-coding GIFtS: 60
GCID: GC08M095384

RAD54 Homolog B (S. Cerevisiae)

See RAD54B-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
RAD54 Homolog B (S. Cerevisiae)¹ ²
RDH54²
DNA Repair And Recombination Protein RAD54B²
EC 3.6.4.-³
RAD54 Homolog B³
EC 3.6.1⁸

External Ids:	HGNC: 17228¹	Entrez Gene: 25788²	Ensembl: ENSG00000197275⁷	OMIM: 604289⁵	UniProtKB: Q9Y620³

Export aliases for RAD54B gene to outside databases

Previous GC identifers: GC08M094130 GC08M095230 GC08M095052 GC08M095340 GC08M095453 GC08M090593

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD54B Gene:

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with

Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of

DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is

highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination.

Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. (provided by RefSeq, Jul

2008)

GeneCards Summary for RAD54B Gene:

RAD54B (RAD54 homolog B (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD54B include colon cancer, somatic, and non-hodgkin lymphoma. GO annotations related to this gene include DNA helicase activity and DNA translocase activity. An important paralog of this gene is RAD54L2.

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in

concert with other members of the RAD52 epistasis group

Gene Wiki entry for RAD54B Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:

Regulatory transcription factor binding sites in the RAD54B gene promoter:
Pbx1a AML1a MEF-2 Evi-1 GATA-1 MEF-2A POU2F1a FOXJ2 (long isoform) FOXJ2 aMEF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): RAD54B promoter sequence

Search Chromatin IP Primers for RAD54B

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD54B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1 Ensembl cytogenetic band: 8q22.1 HGNC cytogenetic band: 8q22.1

RAD54B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD54B gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M095384: view genomic region (about GC identifiers)

Start:	95,384,188 bp from pter	End:	95,487,343 bp from pter
Size:	103,156 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620 (See protein sequence)

Recommended Name: DNA repair and recombination protein RAD54B

Size: 910 amino acids; 102967 Da

Subunit: Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the

interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect

Secondary accessions: F6WBS8

Alternative splicing: 2 isoforms: Q9Y620-1 Q9Y620-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD54B: NX_Q9Y620

Explore proteomics data for RAD54B at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for RAD54B (Q9Y620) (see all 7)

GGVGLNL

MGLGKTL

IYRLLTT

GTIEEKI

See RAD54B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts):

NP_001192191.1 NP_001192192.1 NP_036547.1

ENSEMBL proteins:

ENSP00000336606 ENSP00000430808 ENSP00000430570 ENSP00000428554 ENSP00000430153

RAD54B Human Recombinant Protein Products:

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	Browse Proteins at Cloud-Clone Corp.
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	antibodies-online proteins for RAD54B (4 products)
	antibodies-online peptides for RAD54B

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	antibodies-online antibodies for RAD54B (43 products)

RAD54B Assay Products:

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	antibodies-online kits for RAD54B (6 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:

IPR000330 SNF2_N

IPR027417 P-loop_NTPase

IPR014001 Helicase_ATP-bd

IPR001650 Helicase_C

Graphical View of Domain Structure for InterPro Entry Q9Y620

ProtoNet protein and cluster: Q9Y620

1 Blocks protein domain: IPB000330 SNF2 related domain

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Similarity: Belongs to the SNF2/RAD54 helicase family

Similarity: Contains 1 helicase ATP-binding domain

Similarity: Contains 1 helicase C-terminal domain

Find genes that share domains with RAD54B About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: RA54B_HUMAN, Q9Y620

Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in

concert with other members of the RAD52 epistasis group

Genatlas biochemistry entry for RAD54B:

yeast (S cerevisiae) RAD54 homolog,recombination gene,highly expressed in testis and spleen,homozygously mutated

in primary lymphoma and colon cancer

Enzyme Numbers (IUBMB): EC 3.6.1² EC 3.6.4.-¹

Gene Ontology (GO): Selected molecular function terms (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003678	DNA helicase activity	TAS	10362364
GO:0003724	RNA helicase activity	TAS	10362364
GO:0004386	helicase activity	--	--

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Phenotypes:
4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rad54b):

cellular

hematopoietic system

homeostasis/metabolism

mortality/aging

Find genes that share phenotypes with RAD54B About GenesLikeMe

Animal Models:
MGI mouse knock-out Rad54b^tm1Roka for RAD54B

genOway: Develop your customized and physiologically relevant rodent model for RAD54B

miRNA Products:		miRTarBase miRNAs that target RAD54B: hsa-mir-215-5p (MIRT024274), hsa-mir-192-5p (MIRT026800), hsa-mir-346 (MIRT042701)

		Block miRNA regulation of human, mouse, rat RAD54B using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate RAD54B:
		hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
		SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RAD54B
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for RAD54B

Clone Products:		OriGene clones in human, mouse for RAD54B (see all 5) OriGene ORF clones in mouse, rat for RAD54B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAD54B
		Browse ESI BIO Cell Lines and PureStem Progenitors for RAD54B

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

RA54B_HUMAN, Q9Y620: Nucleus (Probable)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
nucleus	4
cytosol	2

About this image

Gene Ontology (GO): 1 cellular component term: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RAD54B About

See pathways by source

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by

SuperPath

Contained pathways About

Homologous recombination

Homologous recombination

0.40

Homologous recombination

0.40

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Pathways by source See SuperPaths
Show all pathways

1 BioSystems Pathway for RAD54B

Homologous recombination

1 Kegg Pathway (Kegg details for RAD54B):

Homologous recombination

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for RAD54B
Interactions:

GeneGlobe Interaction Network for RAD54B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for RAD54B (Q9Y620^{2, 3} ENSP00000336606⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 151)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC23	Q9UJX2²^,³, ENSP00000378350⁴	MINT-66948 I2D: score=5 STRING: ENSP00000378350
LNX1	Q8TBB1²^,³, ENSP00000263925⁴	MINT-68231 I2D: score=5 STRING: ENSP00000263925
TRAPPC6A	O75865²^,³, ENSP00000006275⁴	MINT-67956 I2D: score=5 STRING: ENSP00000006275
PSMA1	P25786²^,³	MINT-67096 I2D: score=5
MYO15B	Q96JP2²^,³	MINT-67305 I2D: score=1

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Gene Ontology (GO): 5 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	IDA	16428451
GO:0006200	ATP catabolic process	IDA	16428451
GO:0006312	mitotic recombination	TAS	10362364
GO:0007131	reciprocal meiotic recombination	TAS	10362364
GO:0032508	DNA duplex unwinding	TAS	10362364

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for RAD54B (RA54B)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for RAD54B gene (5 alternative transcripts):

NM_001205262.2 NM_001205263.1 NM_012415.3 NM_006550.1 NM_134434.1

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000336148(uc010may.2 uc003ygk.3 uc003ygl.2) ENST00000519348

ENST00000518358 ENST00000463267 ENST00000523192 ENST00000518998 ENST00000523839

ENST00000297592(uc003ygn.2)

miRNA Products:		Block miRNA regulation of human, mouse, rat RAD54B using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate RAD54B:
		hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
		SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RAD54B
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		GenScript: all cDNA clones in your preferred vector (see all 3): RAD54B (NM_001205262)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54B
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Primer Products:		OriGene qPCR primer pairs and template standards for RAD54B OriGene qSTAR qPCR primer pairs in human, mouse for RAD54B
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat RAD54B
		QuantiTect SYBR Green Assays in human, mouse, rat RAD54B
		QuantiFast Probe-based Assays in human, mouse, rat RAD54B

Selected AceView cDNA sequences (see all 70):

AF007866 AA973748 NM_134434 AF086020 BU956980 CB145803 BX283391 BM930136

AL523600 NM_012415 BU538087 CR602319 H88433 BX955752 BC020668 BE888572

AF112481 BC033710 BX955743 H88371 AW151987 NM_006550 BC001965 BG614632

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD54B (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b
SP1:											-												-
SP2:									-		-
SP3:
SP4:
SP5:																																	-

ECgene alternative splicing isoforms for RAD54B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RAD54B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

RAD54B expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 7) fully expand


Brain (Nervous System) fully expand to see all 5 entries
Adult Endothelial Cells Blood Brain Barrier
Cerebral Cortex

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Thymus (Hematopoietic System)
Thymus

Testis (Reproductive System)
XY Germ Cells Testis Cord

Endothelium (Cardiovascular System)
Adult Endothelial Cells Blood Brain Barrier

RAD54B Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

RAD54B Protein Expression

UniProtKB/Swiss-Prot: RA54B_HUMAN, Q9Y620

Tissue specificity: Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate,

ovary and colon

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD54B gene from Selected species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Rad54b^{1 , 5}	RAD54 homolog B (S. cerevisiae)^{1, 5}	83.07(n)¹ 80.61(a)¹		4 (5.11 cM)⁵ 623474¹ NM_001039556.3¹ NP_001034645.1¹ 11558922⁵
chicken (Gallus gallus)	Aves	RAD54B¹	RAD54 homolog B (S. cerevisiae)	72.2(n) 70.24(a)		395449 NM_204710.1 NP_990041.1
lizard (Anolis carolinensis)	Reptilia	RAD54B⁶	RAD54 homolog B (S. cerevisiae)	71(a)	1 ↔ 1	4(18975516-19014898)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32066²	Xenopus laevis transcribed sequence with weak similarity more	75.95(n)		BJ627295.1
zebrafish (Danio rerio)	Actinopterygii	rad54b¹	RAD54 homolog B (S. cerevisiae)	57.95(n) 57.16(a)		560482 XM_683887.6 XP_688979.4
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP006945¹	AgaP_AGAP006945	48.5(n) 46.17(a)		1270139 XM_308811.4 XP_308811.4
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	RDH54(YBR073W)⁴ RDH54¹	DNA-dependent ATPase, stimulates strand exchange by more⁴ RDH54¹	49.37(n)¹ 43.3(a)¹		2(383112-385988)⁴ 852365^{1, 4} NP_009629.6¹ NP_009629.2⁴

ENSEMBL Gene Tree for RAD54B (if available)
TreeFam Gene Tree for RAD54B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RAD54B gene

RAD54L2² ATRX² RAD54L²

2 SIMAP similar genes for RAD54B using alignment to 4 protein entries: RA54B_HUMAN (see all proteins):

DKFZp434J1672 RAD54L

Find genes that share paralogs with RAD54B About GenesLikeMe

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs114216685^1,2,,4	C,F	A non-Hodgkin lymphoma sample⁴ pathogenic¹	95560378(+)	`GGTGAT/CTGCAC`	4	/N /S	mis¹		3		EA NA	640
VAR_019563⁴		A colon cancer sample⁴	--	see VAR_019563	2	D Y	mis⁴		0	--	--	--	--
rs35880440^1,2	C	--	90625080(+)	`GCAGT-/ATGTTTG`	2	--	int¹		0	--	--	--	--
rs13439554^1,2	A	--	90643779(+)	`aaaaaA/Tatata`	2	--	int¹ trp³		0	--	--	--	--
rs137936104^1,2	C	--	90670210(+)	`GCATG-/CA /CACACACAC`	2	--	int¹		0	--	--	--	--
rs34711293^1,2	C	--	95385638(+)	`TGGCC-/TTATGG`	2	--	int¹		2		NA CSA	4
rs59955111^1,2	C	--	95390204(+)	`AAAAA-/AAAGATTC`	2	--	int¹		1		NA	2
rs35744651^1,2	C	--	95393356(+)	`CTTTT-/AAAAAA`	2	--	int¹		1		NA	2
rs35352826^1,2	C	--	95396441(+)	`GCAAC-/ATTATT`	2	--	int¹		1		NA	2
rs11273608^1,2	C	--	95396749(+)	`TAGAT-/TTCAGTTTTGT TTGCAAAACTGAAATAGT`	2	--	int¹		1		NA	2

HapMap Linkage Disequilibrium report for RAD54B (95384188 - 95487343 bp)

Structural Variations
Database of Genomic Variants (DGV) 3 variations for RAD54B: About this table

Variant ID	Type	Subtype	PubMed ID
nsv6313	CNV	Insertion	18451855
nsv891202	CNV	Loss	21882294
nsv831401	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): RAD54B

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RAD54B

DNA2.0 Custom Variant and Variant Library Synthesis for RAD54B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 604289
OMIM disorders: 605027  114500
4 diseases for RAD54B:
About MalaCards

colon cancer, somatic non-hodgkin lymphoma lymphoma, non-hodgkin, somatic colon cancer

Find genes that share disorders with RAD54B About GenesLikeMe

1 Novoseek inferred disease relationship for RAD54B gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	2	15056673 (1)

Genetic Association Database (GAD): RAD54B
Human Genome Epidemiology (HuGE) Navigator: RAD54B (10 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAD54B gene, integrated from 10 sources (see all 42):
(articles sorted by number of sources associating them with RAD54B)

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Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. (PubMed id 10362364)^{1, 2, 3, 9} Hiramoto T.... Kamiya K. (Oncogene 1999)
A novel human Rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)^{1, 2, 3, 9} Tanaka K.... Miyagawa K. (J. Biol. Chem. 2000)
Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. (PubMed id 11884632)^{1, 2, 9} Tanaka K.... Miyagawa K. (Nucleic Acids Res. 2002)
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PubMed id 20610542)^{1, 4} Liu Y....Bondy M.L. (Carcinogenesis 2010)
Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)^{1, 4} Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)^{1, 4} McWilliams R.R....Petersen G.M. (amp 2009)
Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)^{1, 4} Mavaddat N....Pharoah P.D. (amp 2009)
Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)^{1, 4} Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)^{1, 4} Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 25788	HGNC: 17228	AceView: FSBP	Ensembl:ENSG00000197275	euGenes: HUgn25788
ECgene: RAD54B	Kegg: 25788	H-InvDB: RAD54B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for RAD54B	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for RAD54B	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for RAD54B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for RAD54B gene:
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RAD54B Gene

RAD54 Homolog B (S. Cerevisiae)

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RAD54B Gene

RAD54 Homolog B (S. Cerevisiae)

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