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Aliases for RAD54B Gene

Aliases for RAD54B Gene

  • RAD54 Homolog B (S. Cerevisiae) 2 3
  • DNA Repair And Recombination Protein RAD54B 3
  • RAD54 Homolog B 4
  • EC 3.6.4.- 4
  • EC 3.6.1 64
  • RDH54 3

External Ids for RAD54B Gene

Summaries for RAD54B Gene

Entrez Gene Summary for RAD54B Gene

  • The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAD54B Gene

RAD54B (RAD54 Homolog B (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RAD54B include colorectal cancer and lymphoma, non-hodgkin. Among its related pathways are Homologous recombination and Homologous recombination. GO annotations related to this gene include DNA helicase activity and DNA translocase activity. An important paralog of this gene is RAD54L.

UniProtKB/Swiss-Prot for RAD54B Gene

  • Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.

Gene Wiki entry for RAD54B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD54B Gene

Genomics for RAD54B Gene

Genomic Location for RAD54B Gene

Start:
94,371,960 bp from pter
End:
94,475,115 bp from pter
Size:
103,156 bases
Orientation:
Minus strand

Genomic View for RAD54B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD54B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD54B Gene

Regulatory Elements for RAD54B Gene

Proteins for RAD54B Gene

  • Protein details for RAD54B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y620-RA54B_HUMAN
    Recommended name:
    DNA repair and recombination protein RAD54B
    Protein Accession:
    Q9Y620
    Secondary Accessions:
    • F6WBS8

    Protein attributes for RAD54B Gene

    Size:
    910 amino acids
    Molecular mass:
    102967 Da
    Quaternary structure:
    • Interacts with RAD51 through the NH2-terminal domain. Immunoprecipitation experiments show that the interaction is constitutive and not induced by ionizing radiation. The interaction may be indirect.

    Alternative splice isoforms for RAD54B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD54B Gene

Proteomics data for RAD54B Gene at MOPED

Selected DME Specific Peptides for RAD54B Gene

Post-translational modifications for RAD54B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAD54B Gene

Domains for RAD54B Gene

Protein Domains for RAD54B Gene

UniProtKB/Swiss-Prot:

RA54B_HUMAN
Domain:
  • Contains 1 helicase ATP-binding domain.:
    • Q9Y620
  • Contains 1 helicase C-terminal domain.:
    • Q9Y620
Family:
  • Belongs to the SNF2/RAD54 helicase family.:
    • Q9Y620
genes like me logo Genes that share domains with RAD54B: view

No data available for Gene Families for RAD54B Gene

Function for RAD54B Gene

Molecular function for RAD54B Gene

GENATLAS Biochemistry: yeast (S cerevisiae) RAD54 homolog,recombination gene,highly expressed in testis and spleen,homozygously mutated in primary lymphoma and colon cancer
UniProtKB/Swiss-Prot Function: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.

Enzyme Numbers (IUBMB) for RAD54B Gene

Gene Ontology (GO) - Molecular Function for RAD54B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003678 DNA helicase activity TAS 10362364
GO:0003724 RNA helicase activity TAS 10362364
GO:0005524 ATP binding IEA --
GO:0015616 DNA translocase activity IDA 16428451
genes like me logo Genes that share ontologies with RAD54B: view
genes like me logo Genes that share phenotypes with RAD54B: view

Animal Models for RAD54B Gene

MGI Knock Outs for RAD54B:

miRNA for RAD54B Gene

miRTarBase miRNAs that target RAD54B

No data available for Transcription Factor Targeting and HOMER Transcription for RAD54B Gene

Localization for RAD54B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD54B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD54B Gene COMPARTMENTS Subcellular localization image for RAD54B gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for RAD54B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with RAD54B: view

Pathways for RAD54B Gene

genes like me logo Genes that share pathways with RAD54B: view

Pathways by source for RAD54B Gene

1 BioSystems pathway for RAD54B Gene
1 KEGG pathway for RAD54B Gene

Gene Ontology (GO) - Biological Process for RAD54B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IDA 16428451
GO:0006200 obsolete ATP catabolic process --
GO:0006312 mitotic recombination TAS 10362364
GO:0007131 reciprocal meiotic recombination TAS 10362364
GO:0032508 DNA duplex unwinding TAS 10362364
genes like me logo Genes that share ontologies with RAD54B: view

Transcripts for RAD54B Gene

Unigene Clusters for RAD54B Gene

RAD54 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD54B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b
SP1: - -
SP2: - -
SP3:
SP4:
SP5: -
SP6:

Relevant External Links for RAD54B Gene

GeneLoc Exon Structure for
RAD54B
ECgene alternative splicing isoforms for
RAD54B

Expression for RAD54B Gene

mRNA expression in normal human tissues for RAD54B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD54B Gene

SOURCE GeneReport for Unigene cluster for RAD54B Gene Hs.744229

mRNA Expression by UniProt/SwissProt for RAD54B Gene

Q9Y620-RA54B_HUMAN
Tissue specificity: Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate, ovary and colon.
genes like me logo Genes that share expressions with RAD54B: view

Orthologs for RAD54B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD54B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD54B 36
  • 99.63 (n)
  • 99.56 (a)
RAD54B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD54B 36
  • 89.46 (n)
  • 85.79 (a)
RAD54B 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD54B 36
  • 89.66 (n)
  • 85.48 (a)
RAD54B 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad54b 36
  • 83.07 (n)
  • 80.61 (a)
Rad54b 16
Rad54b 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD54B 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD54B 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad54b 36
  • 81.35 (n)
  • 78.03 (a)
chicken
(Gallus gallus)
Aves RAD54B 36
  • 72.2 (n)
  • 70.24 (a)
RAD54B 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD54B 37
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32066 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rad54b 36
  • 65.83 (n)
  • 66.33 (a)
Str.5565 36
zebrafish
(Danio rerio)
Actinopterygii rad54b 36
  • 57.95 (n)
  • 57.16 (a)
rad54b 37
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006945 36
  • 48.5 (n)
  • 46.17 (a)
worm
(Caenorhabditis elegans)
Secernentea Y116A8C.13 38
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL212W 36
  • 48.74 (n)
  • 43.6 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD54 37
  • 33 (a)
OneToMany
RDH54 36
  • 49.37 (n)
  • 43.3 (a)
RDH54 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11814g 36
  • 55.53 (n)
  • 50.57 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rdh54 36
  • 49.9 (n)
  • 41.34 (a)
Species with no ortholog for RAD54B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD54B Gene

ENSEMBL:
Gene Tree for RAD54B (if available)
TreeFam:
Gene Tree for RAD54B (if available)

Paralogs for RAD54B Gene

Paralogs for RAD54B Gene

Selected SIMAP similar genes for RAD54B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RAD54B: view

Variants for RAD54B Gene

Sequence variations from dbSNP and Humsavar for RAD54B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs716770 -- 94,378,693(+) CCACA(C/G/T)ATGCA intron-variant
rs879706 -- 94,425,937(-) TTCAG(A/G/T)GACTG intron-variant
rs882521 -- 94,425,145(+) TTATC(A/G)TCTTA intron-variant
rs935052 -- 94,449,718(-) ATCCT(A/G)AAGGA intron-variant
rs1011249 -- 94,425,833(+) AACCA(A/G)TAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD54B Gene

Variant ID Type Subtype PubMed ID
nsv831401 CNV Loss 17160897
nsv6313 CNV Insertion 18451855
nsv891202 CNV Loss 21882294

Relevant External Links for RAD54B Gene

HapMap Linkage Disequilibrium report
RAD54B
Human Gene Mutation Database (HGMD)
RAD54B

Disorders for RAD54B Gene

(2) OMIM Diseases for RAD54B Gene (604289)

(1) Novoseek inferred disease relationships for RAD54B Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1

Relevant External Links for RAD54B

Genetic Association Database (GAD)
RAD54B
Human Genome Epidemiology (HuGE) Navigator
RAD54B
genes like me logo Genes that share disorders with RAD54B: view

No data available for UniProtKB/Swiss-Prot for RAD54B Gene

Publications for RAD54B Gene

  1. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. (PMID: 10362364) Hiramoto T. … Kamiya K. (Oncogene 1999) 2 3 4 23
  2. A novel human Rad54 homologue, Rad54B, associates with Rad51. (PMID: 10851248) Tanaka K. … Miyagawa K. (J. Biol. Chem. 2000) 2 3 4 23
  3. Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. (PMID: 11884632) Tanaka K. … Miyagawa K. (Nucleic Acids Res. 2002) 3 4 23
  4. A role for RAD54B in homologous recombination in human cells. (PMID: 11782437) Miyagawa K. … Tanaka K. (EMBO J. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for RAD54B Gene

Sources for RAD54B Gene

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