RAD54B Gene

Aliases
for RAD54B gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC08M094130 GC08M095230 GC08M095052 GC08M095340 GC08M095453 GC08M090593

Summaries
for RAD54B gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for RAD54B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmids (see all 2): RAD54B promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD54B

RAD54B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M095384:  view genomic region     (about GC identifiers)

Proteins
for RAD54B gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for RAD54B: NX_Q9Y620

Explore proteomics data for RAD54B at MOPED

Post-translational modifications: 

RAD54B Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for RAD54B
	antibodies-online proteins for RAD54B (4 products)
	antibodies-online peptides for RAD54B

RAD54B Antibody Products:

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	antibodies-online antibodies for RAD54B (43 products)

RAD54B Assay Products:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for RAD54B
	antibodies-online kits for RAD54B (6 products)

Domains /
Families
for RAD54B gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9Y620

Find genes that share domains with RAD54B           About GenesLikeMe

Function
for RAD54B gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

(inferred from 1 allele) (MGI details for Rad54b)

genOway: Develop your customized and physiologically relevant rodent model for RAD54B

miRNA Products:		miRTarBase miRNAs that target RAD54B: hsa-mir-215-5p (MIRT024274), hsa-mir-192-5p (MIRT026800), hsa-mir-346 (MIRT042701)
		Block miRNA regulation of human, mouse, rat RAD54B using miScript Target Protectors
		4 qRT-PCR Assays for microRNAs that regulate RAD54B:
		hsa-miR-942 hsa-miR-129-5p hsa-miR-765 hsa-miR-421
		SwitchGear 3'UTR luciferase reporter plasmid: RAD54B 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for RAD54B
		Predesigned siRNA for gene silencing in human, mouse, rat RAD54B

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for RAD54B

Clone Products:		OriGene clones in human, mouse for RAD54B (see all 5) OriGene ORF clones in mouse, rat for RAD54B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): RAD54B (NM_001205262)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD54B
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD54B

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for RAD54B
		Browse ESI BIO Cell Lines and PureStem Progenitors for RAD54B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

Localization
for RAD54B gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	4
cytosol	2

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Gene Ontology (GO): 1 cellular component term:    About this table

Pathways & Interactions
for RAD54B gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RAD54B About     See pathways by source

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	SuperPath	Contained pathways About
1	Homologous recombination	Homologous recombination 0.40 Homologous recombination 0.40

1 BioSystems Pathway for RAD54B

Homologous recombination

1 Kegg Pathway  (Kegg details for RAD54B)

Homologous recombination

Gene Ontology (GO): 5 biological process terms:    About this table

Drugs & Compounds
for RAD54B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for RAD54B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for RAD54B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RAD54B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

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Brain (Nervous System)    fully expand to see all 5 entries
Adult Endothelial Cells Blood Brain Barrier
Cerebral Cortex
Neural Tube (Nervous System)    fully expand to see all 3 entries
Metencephalon
Thymus (Hematopoietic System)
Thymus
Testis (Reproductive System)
XY Germ Cells Testis Cord
Endothelium (Cardiovascular System)
Adult Endothelial Cells Blood Brain Barrier

Primer Products:		OriGene qPCR primer pairs and template standards for RAD54B OriGene qSTAR qPCR primer pairs in human, mouse for RAD54B
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD54B
		QuantiTect SYBR Green Assays in human, mouse, rat RAD54B
		QuantiFast Probe-based Assays in human, mouse, rat RAD54B

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD54B

Orthologs
for RAD54B gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for RAD54B gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for RAD54B gene

RAD54L2²  ATRX²  RAD54L²  

2 SIMAP similar genes for RAD54B using alignment to 4 protein entries:     RA54B_HUMAN (see all proteins):

DKFZp434J1672    RAD54L

Find genes that share paralogs with RAD54B           About GenesLikeMe

Genomic Variants
for RAD54B gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RAD54B (see all 2001)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1142166851,2,,4	C,F	A non-Hodgkin lymphoma sample4 pathogenic1	95560378(+)	GGTGAT/CTGCAC	4	/N /S	mis1		3		EA NA	640
VAR_0195634		A colon cancer sample4	--	see VAR_019563	2	D Y	mis4		0	--	--	--	--
rs358804401,2	C	--	90625080(+)	GCAGT-/ATGTTTG	2	--	int1		0	--	--	--	--
rs134395541,2	A	--	90643779(+)	aaaaaA/Tatata	2	--	int1 trp3		0	--	--	--	--
rs1379361041,2	C	--	90670210(+)	GCATG-/CA        /CACACACAC	2	--	int1		0	--	--	--	--
rs347112931,2	C	--	95385638(+)	TGGCC-/TTATGG	2	--	int1		2		NA CSA	4
rs599551111,2	C	--	95390204(+)	AAAAA-/AAAGATTC	2	--	int1		1		NA	2
rs357446511,2	C	--	95393356(+)	CTTTT-/AAAAAA	2	--	int1		1		NA	2
rs353528261,2	C	--	95396441(+)	GCAAC-/ATTATT	2	--	int1		1		NA	2
rs112736081,2	C	--	95396749(+)	TAGAT-/TTCAGTTTTGT TTGCAAAACTGAAATAGT	2	--	int1		1		NA	2

HapMap Linkage Disequilibrium report for RAD54B (95384188 - 95487343 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for RAD54B:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv6313	CNV	Insertion	18451855
nsv891202	CNV	Loss	21882294
nsv831401	CNV	Loss	17160897

Human Gene Mutation Database (HGMD): RAD54B

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing RAD54B

DNA2.0 Custom Variant and Variant Library Synthesis for RAD54B

Disorders / Diseases
for RAD54B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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4 diseases for RAD54B

1 Novoseek inferred disease relationship for RAD54B gene    About this table

Publications
for RAD54B gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for RAD54B gene, integrated from 10 sources (see all 42): (articles sorted by number of sources associating them with RAD54B)

Utopia: connect your pdf to the dynamic world of online information

1. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. (PubMed id 10362364)^{1, 2, 3, 9} Hiramoto T.... Kamiya K. (Oncogene 1999)
2. A novel human Rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)^{1, 2, 3, 9} Tanaka K.... Miyagawa K. (J. Biol. Chem. 2000)
3. Human Rad54B is a double-stranded DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54. (PubMed id 11884632)^{1, 2, 9} Tanaka K.... Miyagawa K. (Nucleic Acids Res. 2002)
4. Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. (PubMed id 20610542)^{1, 4} Liu Y....Bondy M.L. (Carcinogenesis 2010)
5. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)^{1, 4} Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
6. Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. (PubMed id 19690177)^{1, 4} McWilliams R.R....Petersen G.M. (amp 2009)
7. Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. (PubMed id 19124506)^{1, 4} Mavaddat N....Pharoah P.D. (amp 2009)
8. Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. (PubMed id 19536092)^{1, 4} Kweekel D.M....Guchelaar H.J. (Br. J. Cancer 2009)
9. Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. (PubMed id 19012493)^{1, 4} Wang S.S....Hildesheim A. (J. Infect. Dis. 2009)
10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)

External Searches for RAD54B gene

Genome Databases showing RAD54B gene

Other Databases showing RAD54B gene

Specialized Databases showing RAD54B gene

Products
for RAD54B gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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