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RAD52 Gene

protein-coding   GIFtS: 63
GCID: GC12M001021

RAD52 Homolog (S. Cerevisiae)

(Previous name: RAD52 (S. cerevisiae) homolog)
  See RAD52-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD52 Homolog (S. Cerevisiae)1 2
RAD52 (S. Cerevisiae) Homolog1
DNA Repair Protein RAD52 Homolog2
Recombination Protein RAD522
Rhabdomyosarcoma Antigen MU-RMS-40.232

External Ids:    HGNC: 98241   Entrez Gene: 58932   Ensembl: ENSG000000020167   OMIM: 6003925   UniProtKB: P433513   

Export aliases for RAD52 gene to outside databases

Previous GC identifers: GC12M000841 GC12M000891


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD52 Gene:
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for
DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded
DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was
also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA
recombination and repair. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAD52 Gene:
RAD52 (RAD52 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD52 include familial chronic lymphocytic leukemia, and acoustic neuroma. GO annotations related to this gene include identical protein binding.

UniProtKB/Swiss-Prot: RAD52_HUMAN, P43351
Function: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair
by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

Gene Wiki entry for RAD52 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009759.17  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD52 gene promoter:
         p53   GATA-3   ZIC2/Zic2   GATA-1   GATA-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD52 promoter sequence
   Search Chromatin IP Primers for RAD52

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD52


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13-p12.2   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13-p12.2

RAD52 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD52 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M001021:  view genomic region     (about GC identifiers)

Start:
1,021,243 bp from pter      End:
1,099,219 bp from pter
Size:
77,977 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RAD52_HUMAN, P43351 (See protein sequence)
Recommended Name: DNA repair protein RAD52 homolog  
Size: 418 amino acids; 46169 Da
Subunit: The full-length protein forms heptameric rings. Interacts with ABL1
2 PDB 3D structures from and Proteopedia for RAD52:
1H2I (3D)        1KN0 (3D)    
Secondary accessions: Q13205 Q9Y5T7 Q9Y5T8 Q9Y5T9
Alternative splicing: 4 isoforms:  P43351-1   P43351-2   P43351-3   P43351-4   (Unable to interact with isoform alpha, may act as dominant negative)

Explore the universe of human proteins at neXtProt for RAD52: NX_P43351

Explore proteomics data for RAD52 at MOPED

Post-translational modifications: 

  • Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAD52 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_602296.2  
    ENSEMBL proteins: 
     ENSP00000351284   ENSP00000434703   ENSP00000387901   ENSP00000439583   ENSP00000436008  
     ENSP00000440486   ENSP00000441073   ENSP00000380407   ENSP00000443254   ENSP00000438965  
     ENSP00000445245   ENSP00000440268  
    Reactome Protein details: P43351

    RAD52 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD52

     
    Search eBioscience for Proteins for RAD52 

     
    antibodies-online proteins for RAD52 (4 products) 

     
    antibodies-online peptides for RAD52

    RAD52 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for RAD52 (72 products) 

    RAD52 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RAD52
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD52
    Cloud-Clone Corp. CLIAs for RAD52
    Search eBioscience for ELISAs for RAD52 
    antibodies-online kits for RAD52 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004585 DNA_recomb/repair_Rad52
     IPR007232 Rad52_Rad22

    Graphical View of Domain Structure for InterPro Entry P43351

    ProtoNet protein and cluster: P43351

    1 Blocks protein domain: IPB007232 Rad52/22 double-strand break repair protein

    UniProtKB/Swiss-Prot: RAD52_HUMAN, P43351
    Similarity: Belongs to the RAD52 family


    Find genes that share domains with RAD52           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD52_HUMAN, P43351
    Function: Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair
    by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase

         Genatlas biochemistry entry for RAD52:
    yeast (S cerevisiae) RAD52 homolog complexing with phosphorylated BRCA1,BRCA2 and RAD51 for DNA repair of double
    strand breaks through homologous recombination,also involved in meiotic recombination,not involved in breast
    cancer

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI12750383
    GO:0042802identical protein binding IPI12750383
         
    Find genes that share ontologies with RAD52           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD52:
     Decreased viability of wild-ty 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad52):
     cellular  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  reproductive system  tumorigenesis 

    Find genes that share phenotypes with RAD52           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad52tm1Aps for RAD52

       genOway: Develop your customized and physiologically relevant rodent model for RAD52

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAD52:
    hsa-mir-373-3p (MIRT003914), hsa-mir-210-3p (MIRT000156)

    Block miRNA regulation of human, mouse, rat RAD52 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate RAD52:
    hsa-miR-433 hsa-miR-145* hsa-miR-137 hsa-miR-198 hsa-miR-2114* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidRAD52 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD52

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: RAD52 (NM_134424)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD52
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD52

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD52


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAD52_HUMAN, P43351: Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS7774919
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with RAD52           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD52 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40
    2Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Presynaptic phase of homologous DNA pairing and strand exchange0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    Assembly of the RAD51-ssDNA nucleoprotein complex0.00
    Homologous DNA pairing and strand exchange0.00
    3Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    DNA Damage0.32
    4DNA Repair
    DNA Repair0.45
    5p53 signaling pathway
    DNA damage response0.41


    Find genes that share SuperPaths with RAD52           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for RAD52
        Cell Cycle / Checkpoint Control
    DNA Damage

    4 BioSystems Pathways for RAD52
        DNA damage response
    Homologous recombination
    miRNAs involved in DDR
    Integrated Pancreatic Cancer Pathway

    2 Reactome Pathways for RAD52
        Presynaptic phase of homologous DNA pairing and strand exchange
    Assembly of the RAD51-ssDNA nucleoprotein complex


    1 Kegg Pathway  (Kegg details for RAD52):
        Homologous recombination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD52: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD52

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD52 (P433511, 2, 3 ENSP000003512844) via UniProtKB, MINT, STRING, and/or I2D (see all 471)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WRNQ141911, 2, 3, ENSP000002981394EBI-706448,EBI-368417 MINT-6550741 MINT-17110 MINT-6550731 MINT-6550722 MINT-6550777 MINT-17109 MINT-6550709 MINT-6550679 MINT-6550697 MINT-6550759 I2D: score=4 STRING: ENSP00000298139
    ENSG00000237724P081073, ENSP000004063594I2D: score=1 STRING: ENSP00000406359
    ENSG00000212866P081073I2D: score=1 
    ENSG00000215328P081073I2D: score=1 
    ENSG00000224501P081073I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0000730DNA recombinase assembly TAS--
    GO:0006281DNA repair TAS--
    GO:0006302double-strand break repair TAS--
    GO:0006310DNA recombination ----

    Find genes that share ontologies with RAD52           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD52

    3 Novoseek inferred chemical compound relationships for RAD52 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methylmethanesulfonate 60.3 5 18396468 (3), 11129042 (1)
    camptothecin 25.1 2 8226741 (1), 15929725 (1)
    cisplatin 0 1 16630539 (1)

    2 PharmGKB related drug/compound annotations for RAD52 gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    cyclophosphamideCA  



    Find genes that share compounds with RAD52           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD52 gene (3 alternative transcripts): 
    NM_134424.2  NM_134422.1  NM_134423.1  

    Unigene Cluster for RAD52:

    RAD52 homolog (S. cerevisiae)
    Hs.410355  [show with all ESTs]
    Unigene Representative Sequence: BC144458
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000358495(uc001qis.1 uc001qit.1 uc010sdt.1 uc001qiu.1)
    ENST00000228345 ENST00000468231 ENST00000481052 ENST00000430095 ENST00000488642(uc001qiw.1)
    ENST00000535376 ENST00000542297 ENST00000543912 ENST00000461568(uc001qiv.1 uc001qix.1)
    ENST00000463750 ENST00000536177(uc010sdu.1) ENST00000542584 ENST00000545967
    ENST00000542785 ENST00000397230 ENST00000544742 ENST00000541619
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate RAD52:
    hsa-miR-433 hsa-miR-145* hsa-miR-137 hsa-miR-198 hsa-miR-2114* hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidRAD52 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD52
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    GenScript: all cDNA clones in your preferred vector: RAD52 (NM_134424)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD52
      QuantiTect SYBR Green Assays in human, mouse, rat RAD52
      QuantiFast Probe-based Assays in human, mouse, rat RAD52

    Additional mRNA sequence: 

    AF125950.1 AK290047.1 AK292160.1 AK294709.1 AK299283.1 AK312026.1 AY540753.1 BC042136.1 
    BC104015.1 BC104017.1 BC114507.1 BC114954.1 BC144458.1 L33262.1 U12134.1 U27516.1 

    14 DOTS entries:

    DT.413599  DT.438191  DT.121200781  DT.433136  DT.121200733  DT.92459662  DT.95155634  DT.100744024 
    DT.121200703  DT.121200712  DT.40118108  DT.440257  DT.100739852  DT.95185605 

    Selected AceView cDNA sequences (see all 118):

    BX327490 AF125950 AA331560 CA487440 BQ923202 AI220389 AI355618 AA256360 
    W87356 AA830197 AA256264 CA775709 BI856889 AA948349 AI239991 AI418283 
    AW949385 AI142118 BE386401 AA401907 AW016336 N53449 AI990082 AI458538 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD52 (see all 16)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^
    SP1:                                -     -     -     -     -     -     -     -     -     -     -     -                       -     -     -           -     -   
    SP2:                                                                                                  -                       -     -     -                     
    SP3:                                                                                                  -                       -     -     -           -     -   
    SP4:                                                                                                  -                             -     -           -     -   
    SP5:                                                                                                                                                            

    ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
    SP1:        -                 -     -     -                 -                           
    SP2:                          -     -     -                                             
    SP3:        -                 -     -     -                 -                           
    SP4:        -                                               -                           
    SP5:        -                 -     -                       -                           


    ECgene alternative splicing isoforms for RAD52

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD52 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACAGAGTT
    RAD52 Expression
    About this image

    RAD52 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD52 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410355
        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD52: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD52

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for RAD52 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad521 , 5 RAD52 homolog (S. cerevisiae)1, 5 77.5(n)1
    72.17(a)1
      6 (56.86 cM)5
    193651  NM_001166381.11  NP_001159853.11 
     1199026985 
    chicken
    (Gallus gallus)
    Aves RAD521 RAD52 homolog (S. cerevisiae) 64.4(n)
    61.88(a)
      418152  NM_001167759.1  NP_001161231.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD526
    RAD52 homolog (S. cerevisiae)
    81(a)
    1 ↔ 1
    5(12351838-12360427)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.204232 Transcribed sequence with moderate similarity to protein spP43351 (H.sapiens) RA52_HUMAN DNA repair protein RAD52 homolog less 80.39(n)    AL855367.2 
    zebrafish
    (Danio rerio)
    Actinopterygii rad521 RAD52 homolog (S. cerevisiae) 56.32(n)
    50.4(a)
      554171  NM_001024451.1  NP_001019622.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD52(YML032C)4 Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis less   --   13(213930-212515) 854976  NP_013680.2 


    ENSEMBL Gene Tree for RAD52 (if available)
    TreeFam Gene Tree for RAD52 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD52 gene

    Find genes that share paralogs with RAD52           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for RAD52
    PGOHUM00000240444


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD52 (see all 1043)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048950571,2
    Cuntested11022104(-) TTAAGC/TACTGT 1 -- ut310--------
    rs1048950681,2
    Cuntested11023462(-) GTCCAG/TTTCCT 1 -- int10--------
    rs1048950701,2
    C,Funtested11036290(-) GGAGTC/TTAACC 1 -- int11Minor allele frequency- T:0.01EU 1323
    rs1048950711,2
    Cuntested11040297(-) GGATTC/TGGAAG 1 -- int10--------
    rs1825274701,2
    --1021150(+) GCACCA/GCTGCA 1 -- ds50010--------
    rs108495841,2
    C,F,A--1021159(+) CACTCC/TAGCCT 1 -- ds500111Minor allele frequency- T:0.44NS NA WA CSA EA 543
    rs596764751,2
    C--1021181(+) CCAGA-/CCCCCC 1 -- ds50010--------
    rs561317261,2
    C--1021188(+) CCCCCC/TCTCAA 1 -- ds50010--------
    rs2009521541,2
    C--1021188(+) CCCCC-/C/CC/T
            
    CTCAA
    1 -- ds50010--------
    rs2020717701,2
    C--1021191(+) CTCTC-/AAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAD52 (1021243 - 1099219 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for RAD52:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745372CNV Deletion23290073
    esv2673796CNV Deletion23128226
    esv2745370CNV Deletion23290073
    esv2745371CNV Deletion23290073
    esv2639640CNV Deletion19546169
    nsv898576CNV Loss21882294
    nsv468962CNV Gain19166990
    nsv470256CNV Gain18288195
    nsv468960CNV Gain19166990
    dgv1339n71CNV Gain21882294

    Human Gene Mutation Database (HGMD): RAD52
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD52
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD52

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600392    OMIM disorders: --

    2 diseases for RAD52:    
    About MalaCards
    familial chronic lymphocytic leukemia    acoustic neuroma


    Find genes that share disorders with RAD52           About GenesLikeMe

    5 Novoseek inferred disease relationships for RAD52 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    germ-line mutation 37.9 2 17405295 (1), 10463575 (1)
    breast cancer 10.1 7 10463575 (3), 17405295 (2), 12023982 (1)
    cancer 5.29 3 18449888 (1), 12883740 (1), 10463575 (1)
    ovarian cancer 0 10 12883740 (4), 15670896 (1)
    tumors 0 1 9353268 (1)

    Genetic Association Database (GAD): RAD52
    Human Genome Epidemiology (HuGE) Navigator: RAD52 (35 documents)

    Export disorders for RAD52 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD52 gene, integrated from 10 sources (see all 165):
    (articles sorted by number of sources associating them with RAD52)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. (PubMed id 7774919)1, 2, 3, 9 Shen Z.... Chen D.J. (Genomics 1995)
    2. Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. (PubMed id 12379650)1, 2, 9 Kitao H. and Yuan Z.M. (J. Biol. Chem. 2002)
    3. Rad52 gene mutations in breast/ovarian cancer families and sporadic ovarian carcinoma patients. (PubMed id 12883740)1, 4, 9 Tong D....Zeillinger R. (Oncol. Rep. 2003)
    4. Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. (PubMed id 7526206)1, 2, 9 Muris D.F.... Pastink A. (Mutat. Res. 1994)
    5. Identification of novel isoforms of human RAD52. (PubMed id 10673031)1, 2, 9 Kito K.... Kamitani T. (Biochim. Biophys. Acta 1999)
    6. Structure of the single-strand annealing domain of human RAD52 protein. (PubMed id 12370410)1, 2, 9 Singleton M.R.... Wigley D.B. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. (PubMed id 18313388)1, 3, 9 McIlwraith M.J. and West S.C. (Mol. Cell 2008)
    8. Variants in DNA double-strand break repair genes and breast cancer susceptibility. (PubMed id 12023982)1, 4, 9 Kuschel B....Dunning A. (Hum. Mol. Genet. 2002)
    9. Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity. (PubMed id 18990028)1, 4, 9 Shin A....Kang D. (Asian Pac. J. Cancer Prev. 2008)
    10. Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. (PubMed id 18449888)1, 4, 9 Danoy P....Benhamou S. (Int. J. Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5893 HGNC: 9824 AceView: RAD52 Ensembl:ENSG00000002016 euGenes: HUgn5893
    ECgene: RAD52 Kegg: 5893 H-InvDB: RAD52

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD52 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD52 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad52/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD52 gene:
    Search GeneIP for patents involving RAD52

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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