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Aliases for RAD52 Gene

Aliases for RAD52 Gene

  • RAD52 Homolog, DNA Repair Protein 2 3 5
  • RAD52 (S. Cerevisiae) Homolog 2
  • RAD52 Homolog (S. Cerevisiae) 2

External Ids for RAD52 Gene

Previous GeneCards Identifiers for RAD52 Gene

  • GC12M000841
  • GC12M000891
  • GC12M001021

Summaries for RAD52 Gene

Entrez Gene Summary for RAD52 Gene

  • The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

GeneCards Summary for RAD52 Gene

RAD52 (RAD52 Homolog, DNA Repair Protein) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and SUMOylation. GO annotations related to this gene include identical protein binding and recombinase activity.

UniProtKB/Swiss-Prot for RAD52 Gene

  • Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Gene Wiki entry for RAD52 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD52 Gene

Genomics for RAD52 Gene

Regulatory Elements for RAD52 Gene

Genomic Location for RAD52 Gene

Chromosome:
12
Start:
911,259 bp from pter
End:
990,608 bp from pter
Size:
79,350 bases
Orientation:
Minus strand

Genomic View for RAD52 Gene

Genes around RAD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD52 Gene

Proteins for RAD52 Gene

  • Protein details for RAD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43351-RAD52_HUMAN
    Recommended name:
    DNA repair protein RAD52 homolog
    Protein Accession:
    P43351
    Secondary Accessions:
    • Q13205
    • Q9Y5T7
    • Q9Y5T8
    • Q9Y5T9

    Protein attributes for RAD52 Gene

    Size:
    418 amino acids
    Molecular mass:
    46169 Da
    Quaternary structure:
    • The full-length protein forms heptameric rings. Interacts with ABL1. Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex.

    Three dimensional structures from OCA and Proteopedia for RAD52 Gene

    Alternative splice isoforms for RAD52 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD52 Gene

Proteomics data for RAD52 Gene at MOPED

Post-translational modifications for RAD52 Gene

  • Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for RAD52 Gene

Domains & Families for RAD52 Gene

Protein Domains for RAD52 Gene

Graphical View of Domain Structure for InterPro Entry

P43351

UniProtKB/Swiss-Prot:

RAD52_HUMAN :
  • Belongs to the RAD52 family.
Family:
  • Belongs to the RAD52 family.
genes like me logo Genes that share domains with RAD52: view

No data available for Gene Families for RAD52 Gene

Function for RAD52 Gene

Molecular function for RAD52 Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) RAD52 homolog complexing with phosphorylated BRCA1,BRCA2 and RAD51 for DNA repair of double strand breaks through homologous recombination,also involved in meiotic recombination,not involved in breast cancer
UniProtKB/Swiss-Prot Function:
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Gene Ontology (GO) - Molecular Function for RAD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IPI 12750383
genes like me logo Genes that share ontologies with RAD52: view
genes like me logo Genes that share phenotypes with RAD52: view

Animal Models for RAD52 Gene

MGI Knock Outs for RAD52:

Animal Model Products

miRNA for RAD52 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD52 Gene

Localization for RAD52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD52 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD52 Gene COMPARTMENTS Subcellular localization image for RAD52 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for RAD52 Gene

Pathways & Interactions for RAD52 Gene

genes like me logo Genes that share pathways with RAD52: view

Gene Ontology (GO) - Biological Process for RAD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000730 DNA recombinase assembly IEA --
GO:0006310 DNA recombination IEA,IMP 8702565
GO:0006974 cellular response to DNA damage stimulus IGI 19506022
GO:0016925 protein sumoylation TAS --
GO:0034599 cellular response to oxidative stress IDA 19506022
genes like me logo Genes that share ontologies with RAD52: view

No data available for SIGNOR curated interactions for RAD52 Gene

Drugs & Compounds for RAD52 Gene

(3) Drugs for RAD52 Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2540
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2643

(1) Additional Compounds for RAD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAD52: view

Transcripts for RAD52 Gene

Unigene Clusters for RAD52 Gene

RAD52 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD52 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6:
SP7: - -
SP8: -
SP9: -
SP10:
SP11: - - -
SP12: - - - -
SP13: - - - - - - - -
SP14:
SP15: -
SP16:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16: - -

Relevant External Links for RAD52 Gene

GeneLoc Exon Structure for
RAD52
ECgene alternative splicing isoforms for
RAD52

Expression for RAD52 Gene

mRNA expression in normal human tissues for RAD52 Gene

Protein differential expression in normal tissues from HIPED for RAD52 Gene

This gene is overexpressed in Lung (44.8) and Esophagus (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAD52 Gene



SOURCE GeneReport for Unigene cluster for RAD52 Gene Hs.410355

genes like me logo Genes that share expression patterns with RAD52: view

Protein tissue co-expression partners for RAD52 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAD52 Gene

Orthologs for RAD52 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD52 35
  • 98.16 (n)
  • 96.4 (a)
RAD52 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD52 36
  • 71 (a)
OneToOne
RAD52 35
  • 79.55 (n)
  • 74.93 (a)
dog
(Canis familiaris)
Mammalia RAD52 35
  • 82.03 (n)
  • 75.06 (a)
RAD52 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad52 16
Rad52 36
  • 70 (a)
OneToOne
Rad52 35
  • 77.5 (n)
  • 72.17 (a)
oppossum
(Monodelphis domestica)
Mammalia RAD52 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD52 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad52 35
  • 74.17 (n)
  • 68.56 (a)
chicken
(Gallus gallus)
Aves RAD52 35
  • 64.4 (n)
  • 61.88 (a)
RAD52 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD52 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad52 35
  • 60.51 (n)
  • 57.72 (a)
Str.20423 35
zebrafish
(Danio rerio)
Actinopterygii rad52 36
  • 47 (a)
OneToOne
rad52 35
  • 56.32 (n)
  • 50.4 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD52 36
  • 24 (a)
OneToOne
RAD52 38
Species with no ortholog for RAD52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD52 Gene

ENSEMBL:
Gene Tree for RAD52 (if available)
TreeFam:
Gene Tree for RAD52 (if available)

Paralogs for RAD52 Gene

Pseudogenes.org Pseudogenes for RAD52 Gene

genes like me logo Genes that share paralogs with RAD52: view

No data available for Paralogs for RAD52 Gene

Variants for RAD52 Gene

Sequence variations from dbSNP and Humsavar for RAD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11571421 - 930,123(-) GTCAT(C/T)GGGTA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs4987206 - 916,703(-) TGCAG(C/G)AGGTG nc-transcript-variant, downstream-variant-500B, reference, missense
rs11571463 - 916,349(-) GAAGA(A/G)TGAGG nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1637 -- 923,384(-) AACAA(G/T)TATTA intron-variant
rs933338 -- 977,419(-) aagca(C/T)ggtaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD52 Gene

Variant ID Type Subtype PubMed ID
nsv898576 CNV Loss 21882294
nsv468960 CNV Gain 19166990
nsv470256 CNV Gain 18288195
dgv1339n71 CNV Gain 21882294
esv2639640 CNV Deletion 19546169
esv2745370 CNV Deletion 23290073
esv2673796 CNV Deletion 23128226
esv2745371 CNV Deletion 23290073
esv2745372 CNV Deletion 23290073
nsv468962 CNV Gain 19166990

Variation tolerance for RAD52 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD52 Gene

HapMap Linkage Disequilibrium report
RAD52
Human Gene Mutation Database (HGMD)
RAD52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD52 Gene

Disorders for RAD52 Gene

Relevant External Links for RAD52

Genetic Association Database (GAD)
RAD52
Human Genome Epidemiology (HuGE) Navigator
RAD52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD52

No disorders were found for RAD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD52 Gene

Publications for RAD52 Gene

  1. The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. (PMID: 7774919) Shen Z. … Chen D.J. (Genomics 1995) 2 3 4 23 67
  2. The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. (PMID: 19506022) de Souza-Pinto N.C. … Bohr V.A. (Mol. Cell. Biol. 2009) 2 3 23
  3. DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. (PMID: 18313388) McIlwraith M.J. … West S.C. (Mol. Cell 2008) 2 3 23
  4. Rad52 protein function study by fluorescence tagging. (PMID: 24340529) Bordeianu G. … Rusu M. (Rev Med Chir Soc Med Nat Iasi 2013) 2 3
  5. Human replication protein A-Rad52-single-stranded DNA complex: stoichiometry and evidence for strand transfer regulation by phosphorylation. (PMID: 19530647) Deng X. … Borgstahl G.E. (Biochemistry 2009) 3 23

Products for RAD52 Gene

Sources for RAD52 Gene

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