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Aliases for RAD52 Gene

Aliases for RAD52 Gene

  • RAD52 Homolog, DNA Repair Protein 2 3 5
  • RAD52 (S. Cerevisiae) Homolog 2
  • RAD52 Homolog (S. Cerevisiae) 2

External Ids for RAD52 Gene

Previous GeneCards Identifiers for RAD52 Gene

  • GC12M000841
  • GC12M000891
  • GC12M001021

Summaries for RAD52 Gene

Entrez Gene Summary for RAD52 Gene

  • The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

GeneCards Summary for RAD52 Gene

RAD52 (RAD52 Homolog, DNA Repair Protein) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and miRNAs involved in DNA damage response. GO annotations related to this gene include identical protein binding and recombinase activity.

UniProtKB/Swiss-Prot for RAD52 Gene

  • Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Gene Wiki entry for RAD52 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD52 Gene

Genomics for RAD52 Gene

Regulatory Elements for RAD52 Gene

Enhancers for RAD52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G000822 1 Ensembl ENCODE 21.1 +167.3 167270 1.1 BACH1 CBX5 RELB IKZF2 CREM MTA2 TRIM22 DPF2 TBX21 EP300 RAD52 ENSG00000250132 ERC1 WNK1 RNU4ATAC16P GC12P000887
GH12G000905 0.8 ENCODE 26.1 +84.8 84761 1.2 ZBTB21 INSM2 MAX ZNF2 ZNF664 ZNF335 ZNF324 ZNF366 POLR2A PATZ1 RAD52 ERC1 ENSG00000250132 GC12M000893 PIR41895
GH12G000851 0.9 Ensembl ENCODE 20.7 +138.6 138605 1.4 TBP JUN CEBPB CEBPG EP300 ZNF121 JUND RAD51 MAFF ZNF629 RAD52 WNK1 ERC1 ENSG00000250132 GC12P000887 RNU4ATAC16P
GH12G000569 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +419.5 419516 3.6 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YBX1 LOC100049716 LOC105369595 WNK1 NINJ2 LOC100288778 ENSG00000250132 ERC1 RAD52 GC12M000554 PIR38262
GH12G000910 0.8 ENCODE 21.7 +79.2 79207 1.6 HDAC1 LEF1 TAL1 TCF12 FOXM1 GATA2 NCOR1 SMARCE1 RNF2 MTA2 RAD52 ERC1 ENSG00000250132 PIR41895 GC12P000912
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAD52 on UCSC Golden Path with GeneCards custom track

Promoters for RAD52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000047616 -592 2401 FOXA2 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 SP3

Genomic Location for RAD52 Gene

Chromosome:
12
Start:
911,259 bp from pter
End:
990,608 bp from pter
Size:
79,350 bases
Orientation:
Minus strand

Genomic View for RAD52 Gene

Genes around RAD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD52 Gene

Proteins for RAD52 Gene

  • Protein details for RAD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43351-RAD52_HUMAN
    Recommended name:
    DNA repair protein RAD52 homolog
    Protein Accession:
    P43351
    Secondary Accessions:
    • Q13205
    • Q9Y5T7
    • Q9Y5T8
    • Q9Y5T9

    Protein attributes for RAD52 Gene

    Size:
    418 amino acids
    Molecular mass:
    46169 Da
    Quaternary structure:
    • The full-length protein forms heptameric rings. Interacts with ABL1. Interacts with RPA2; the interaction is direct and associates RAD52 with the RPA complex.

    Three dimensional structures from OCA and Proteopedia for RAD52 Gene

    Alternative splice isoforms for RAD52 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD52 Gene

Post-translational modifications for RAD52 Gene

  • Phosphorylated upon DNA damage by ABL1, and probably by ATM or ATR.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RAD52
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAD52

No data available for DME Specific Peptides for RAD52 Gene

Domains & Families for RAD52 Gene

Protein Domains for RAD52 Gene

Graphical View of Domain Structure for InterPro Entry

P43351

UniProtKB/Swiss-Prot:

RAD52_HUMAN :
  • Belongs to the RAD52 family.
Family:
  • Belongs to the RAD52 family.
genes like me logo Genes that share domains with RAD52: view

No data available for Gene Families for RAD52 Gene

Function for RAD52 Gene

Molecular function for RAD52 Gene

GENATLAS Biochemistry:
yeast (S cerevisiae) RAD52 homolog complexing with phosphorylated BRCA1,BRCA2 and RAD51 for DNA repair of double strand breaks through homologous recombination,also involved in meiotic recombination,not involved in breast cancer
UniProtKB/Swiss-Prot Function:
Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Gene Ontology (GO) - Molecular Function for RAD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA,TAS 19506022
GO:0003697 single-stranded DNA binding IMP 12370410
GO:0005515 protein binding IPI 8702565
GO:0042802 identical protein binding IPI 12750383
genes like me logo Genes that share ontologies with RAD52: view
genes like me logo Genes that share phenotypes with RAD52: view

Animal Models for RAD52 Gene

MGI Knock Outs for RAD52:

Animal Model Products

CRISPR Products

miRNA for RAD52 Gene

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD52 Gene

Localization for RAD52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD52 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IDA 19506022
GO:0005654 nucleoplasm TAS --
GO:0032993 protein-DNA complex IMP 12370410
GO:0043234 protein complex IDA 19506022
genes like me logo Genes that share ontologies with RAD52: view

Pathways & Interactions for RAD52 Gene

genes like me logo Genes that share pathways with RAD52: view

Gene Ontology (GO) - Biological Process for RAD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000730 DNA recombinase assembly IEA --
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair TAS 7774919
GO:0006310 DNA recombination IMP 8702565
GO:0006974 cellular response to DNA damage stimulus IGI 19506022
genes like me logo Genes that share ontologies with RAD52: view

No data available for SIGNOR curated interactions for RAD52 Gene

Drugs & Compounds for RAD52 Gene

(3) Drugs for RAD52 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2770
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2935

(1) Additional Compounds for RAD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAD52: view

Transcripts for RAD52 Gene

Unigene Clusters for RAD52 Gene

RAD52 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD52 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - - - - -
SP5:
SP6:
SP7: - -
SP8: -
SP9: -
SP10:
SP11: - - -
SP12: - - - -
SP13: - - - - - - - -
SP14:
SP15: -
SP16:

ExUns: 12a · 12b ^ 13 ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16: - -

Relevant External Links for RAD52 Gene

GeneLoc Exon Structure for
RAD52
ECgene alternative splicing isoforms for
RAD52

Expression for RAD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD52 Gene

Protein differential expression in normal tissues from HIPED for RAD52 Gene

This gene is overexpressed in Lung (44.8) and Esophagus (24.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAD52 Gene



Protein tissue co-expression partners for RAD52 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAD52 Gene:

RAD52

SOURCE GeneReport for Unigene cluster for RAD52 Gene:

Hs.410355

Evidence on tissue expression from TISSUES for RAD52 Gene

  • Spleen(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with RAD52: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD52 Gene

Orthologs for RAD52 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD52 34 35
  • 98.16 (n)
dog
(Canis familiaris)
Mammalia RAD52 34 35
  • 82.03 (n)
cow
(Bos Taurus)
Mammalia RAD52 34 35
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia Rad52 34 16 35
  • 77.5 (n)
rat
(Rattus norvegicus)
Mammalia Rad52 34
  • 74.17 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAD52 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD52 35
  • 57 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD52 34 35
  • 64.4 (n)
lizard
(Anolis carolinensis)
Reptilia RAD52 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad52 34
  • 60.51 (n)
Str.20423 34
zebrafish
(Danio rerio)
Actinopterygii rad52 34 35
  • 56.32 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD52 35 37
  • 24 (a)
OneToOne
Species where no ortholog for RAD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD52 Gene

ENSEMBL:
Gene Tree for RAD52 (if available)
TreeFam:
Gene Tree for RAD52 (if available)

Paralogs for RAD52 Gene

Pseudogenes.org Pseudogenes for RAD52 Gene

genes like me logo Genes that share paralogs with RAD52: view

No data available for Paralogs for RAD52 Gene

Variants for RAD52 Gene

Sequence variations from dbSNP and Humsavar for RAD52 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11571493 Likely benign 911,375(-) AAAGC(A/G)CAATC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs11571496 Likely benign 911,266(-) GTACA(C/T)TGTTA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs11571497 Likely benign 911,205(-) AGATA(A/C)TCAAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs147760490 Likely benign 910,556(+) AACTG(G/T)CTATG downstream-variant-500B, utr-variant-3-prime
rs2023943 Likely benign 910,729(+) AGAGG(C/G)TGGAG downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RAD52 Gene

Variant ID Type Subtype PubMed ID
dgv2251n54 CNV gain 21841781
dgv255e199 CNV deletion 23128226
dgv747n106 CNV deletion 24896259
esv2422010 CNV deletion 20811451
esv2639640 CNV deletion 19546169
esv2673796 CNV deletion 23128226
esv2745370 CNV deletion 23290073
esv2745371 CNV deletion 23290073
esv2745372 CNV deletion 23290073
esv3254496 CNV deletion 24192839
esv3548605 CNV deletion 23714750
esv3628261 CNV gain 21293372
esv3628262 CNV loss 21293372
esv3628264 CNV loss 21293372
esv3628266 CNV loss 21293372
nsv1042333 CNV gain 25217958
nsv1119926 CNV deletion 24896259
nsv1153006 CNV deletion 26484159
nsv468962 CNV gain 19166990
nsv516003 CNV loss 19592680
nsv521937 CNV loss 19592680
nsv556942 CNV gain 21841781
nsv818878 CNV loss 17921354
nsv957404 CNV deletion 24416366

Variation tolerance for RAD52 Gene

Residual Variation Intolerance Score: 63.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD52 Gene

Human Gene Mutation Database (HGMD)
RAD52
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD52 Gene

Disorders for RAD52 Gene

Relevant External Links for RAD52

Genetic Association Database (GAD)
RAD52
Human Genome Epidemiology (HuGE) Navigator
RAD52
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD52

No disorders were found for RAD52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD52 Gene

Publications for RAD52 Gene

  1. The human and mouse homologs of the yeast RAD52 gene: cDNA cloning, sequence analysis, assignment to human chromosome 12p12.2-p13, and mRNA expression in mouse tissues. (PMID: 7774919) Shen Z. … Chen D.J. (Genomics 1995) 2 3 4 22 64
  2. The recombination protein RAD52 cooperates with the excision repair protein OGG1 for the repair of oxidative lesions in mammalian cells. (PMID: 19506022) de Souza-Pinto N.C. … Bohr V.A. (Mol. Cell. Biol. 2009) 2 3 22 64
  3. DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. (PMID: 18313388) McIlwraith M.J. … West S.C. (Mol. Cell 2008) 2 3 22 64
  4. Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers. (PMID: 18449888) Danoy P. … Benhamou S. (Int. J. Cancer 2008) 3 22 46 64
  5. Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity. (PMID: 18990028) Shin A. … Kang D. (Asian Pac. J. Cancer Prev. 2008) 3 22 46 64

Products for RAD52 Gene

Sources for RAD52 Gene

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