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Aliases & Descriptions for RAD51L3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases HsTRAD 1 , 2 R51H3 1 , 2 , 3 RAD51D 2 , 3 , 5 TRAD 3 Trad 1 , 2
Descriptions DNA repair protein RAD51 homolog 4 2 RAD51 (S. cerevisiae)-like 3 1 RAD51-like 3 2 RAD51-like 3 (S. cerevisiae) 2 RAD51-like protein 3 3 recombination repair protein 2
Search outside databases for aliases for RAD51L3 genePrevious GC identifers: GC17M033197 GC17M035371 GC17M033572
Summaries for RAD51L3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for RAD51L3 : The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members arehighly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to beinvolved in the homologous recombination and repair of DNA. This protein forms a complex withseveral other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The proteincomplex formed with this protein has been shown to catalyze homologous pairing between single- anddouble-stranded DNA, and is thought to play a role in the early stage of recombinational repair ofDNA. Several alternatively spliced transcript variants of this gene have been described, but thebiological validity of some of them has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 Function : Involved in the homologous recombination repair (HRR) pathway of double-stranded DNAbreaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex bindssingle-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA
Gene Wiki entry for RAD51L3
Genomic Location for RAD51L3
(According to
GeneLoc and/or
HGNC , and/or
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and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the RAD51L3 gene Entrez Gene cytogenetic band: 17q11 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q11 RAD51L3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17M030450:
(about GC identifiers )
Start:
30,450,929 bp from pter
End:
30,471,001 bp from pter
Size:
20,073 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000017.9 NT_010799.14 Proteins for RAD51L3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Sigma-Aldrich ,
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Abcam ,
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 (See
protein sequence )Recommended Name: DNA repair protein RAD51 homolog 4 Size : 328 amino acids; 35049 Da
Subunit : Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complexconsisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Interacts with ZSWIM7
Subcellular location : Nucleus (Probable)
Secondary accessions : O43537 O60355 O75196 O75847 O75848 O76073 O76085 O94908 Q9UFU5Alternative splicing : 7 isoforms : O75771-1 O75771-2 O75771-3 O75771-4 O75771-5 O75771-6 O75771-7
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001136043.1 NP_002869.3 NP_598332.1 ENSEMBL proteins: ENSP00000378090 ENSP00000345934 ENSP00000350581 ENSP00000338408 ENSP00000353417 ENSP00000338790 ENSP00000338301 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for RAD51L3: Assays for RAD51L3:
Protein
Domains/ Families for RAD51L3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75771 ProtoNet protein and cluster: O75771
UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 Similarity : Belongs to the recA family. RAD51 subfamily
Gene Function for RAD51L3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_133628 Applied Biosystems Silencer ® siRNAs for RAD51L3 Sigma-Aldrich siRNA and siRNA Panels for RAD51L3 Sigma-Aldrich shRNA for RAD51L3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142571                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142571                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001142571  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001142571 UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 Function : Involved in the homologous recombination repair (HRR) pathway of double-stranded DNAbreaks arising during DNA replication or induced by DNA-damaging agents. The BCDX2 complex bindssingle-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA
Genatlas biochemistry entry for RAD51L3 :yeast (S cerevisiae) RAD51homolog D,ubiquitously expressed,likely involved in double strand breakrepair and recombination,with three alternative spliced isoforms
7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Rad51l3) :5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
):
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Pathways & Interactions for RAD51L3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for RAD51L3 5/11 Interacting proteins for RAD51L3 (ENSP00000338408 3 O75771 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 11
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for RAD51L3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Transcripts for RAD51L3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_133628 Sigma-Aldrich siRNA and siRNA Panels for RAD51L3 Sigma-Aldrich shRNA for RAD51L3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001142571 NM_002878 NM_133629
REFSEQ mRNAs for RAD51L3 gene (3 alternative transcripts): NM_001142571.1 NM_002878.3 NM_133629.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001142571 NM_002878 NM_133629
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142571                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001142571                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001142571  
Additional cDNA sequence: AB013341.1 AB016223.1 AB016224.1 AB016225.1 AB018360.1 AB018361.1 AB018362.1 AB018363.1 AB020412.1 AF034956.1 AK296241.1 AK301249.1 AK302450.1 AL117459.1 BC002723.2 BC014422.1 BX647297.1 Y15572.1
14 DOTS entries : DT.120964034 DT.40299610 DT.100816286 DT.100816283 DT.95166746 DT.40281551 DT.70102785 DT.75164409 DT.100025408 DT.92026831 DT.95112345 DT.100710693 DT.120964097 DT.40254797
24/183 AceView cDNA sequences (see all 183
):BC002723 BG059956 NM_133629 AI597891 AA282406 BQ027317 BM476849 BG059954 AI241579 NM_133627 BE349405 AI369733 AK097811 BU521767 BI850594 BU681257 BG060071 BC014422 AB018360 AB020412 AW300373 AB016225 NM_133630 BI916871
highest scoring ESTs for RAD51L3 :AF034956 Y15572 AA352205 AB013341 AB016223 AB016224 AB016225 AI561176 AL597240 AU098391
Unigene Cluster for RAD51L3: RAD51-like 3 (S. cerevisiae) Hs.631757 [show with all ESTs ] Unigene Representative Sequence: NM_001142571 GeneLoc Exon Structure 5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51L3 (see all 11
) ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c SP1 :                 -     -                       SP2 :               -   -     -                       SP3 :                 -   -   -                       SP4 :               -   -     -   -   -                   SP5 :               -   -   -   -   -   -                  
About this scheme ECgene alternative splicing isoforms for RAD51L3 7 Ensembl transcripts including schematic representations : ENST00000394589
ENST00000339934
ENST00000357906
ENST00000335858
ENST00000360276
ENST00000345365
ENST00000345766
Expression for RAD51L3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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RAD51L3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for RAD51L3 1 / 2 / 3
7 probe-sets matching RAD51L3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTGGCGACTGSOURCE GeneReport for Unigene cluster: Hs.631757 Expression variation in blood from EXPOLDB for RAD51L3
UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 Tissue specificity : Expressed in colon, prostate, spleen, testis, ovary, thymus and smallintestine. Weakly expressed in leukocytes
Orthologs for RAD51L3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
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and/or
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Orthologs for RAD51L3 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for RAD51L3 ENSEMBL Gene Tree for RAD51L3 Paralogs for RAD51L3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for RAD51L3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for RAD51L3 (up to first 250kb)
Disorders & Mutations for RAD51L3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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OMIM: 602954 Human Gene Mutation Database : RAD51L3 Genetic Association Database: RAD51L3 Human Genome Epidemiology Navigator: RAD51L3 (3 documents)
Medical News for RAD51L3 (Possibly Related Articles in
Doctor's Guide )
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Publications for RAD51L3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/40 PubMed articles for RAD51L3 gene (see all 40
): Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PubMed id 9570954) 1, 2, 3, 4 Pittman D.L.... Schimenti J.C. (1998) The variant E233G of the RAD51D gene could be a low-penetrance allele in high-risk breast cancer families without BRCA1/2 mutations. (PubMed id 15170666) 1, 3, 6 Rodriguez-Lopez R....Benitez J. (2004) Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. (PubMed id 9512535) 1, 3, 4 Cartwright R.... Thacker J. (1998) RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692) 1, 3, 4 Miller K.A....Albala J.S. (2002) Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112) 1, 3, 4 Wiese C....Schild D. (2002) Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family. (PubMed id 10092526) 1, 3, 4 Kawabata M. and Saeki K. (1999) An unappreciated role for RNA surveillance. (PubMed id 14759258) 3, 4 Hillman R.T.... Brenner S.E. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells. (PubMed id 11842113) 3, 4 Liu N.... Thompson L.H. (2002) Identification and purification of two distinct complexes containing the five RAD51 paralogs. (PubMed id 11751635) 3, 4 Masson J.Y.... West S.C. (2001)
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Genome Databases showing RAD51L3
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing RAD51L3
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Specialized Databases showing RAD51L3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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