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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD51D Gene

protein-coding   GIFtS: 54
GCID: GC17M033427

RAD51 Paralog D

(Previous names: RAD51 (S. cerevisiae)-like 3, RAD51-like 3 (S. cerevisiae),...)
(Previous symbol: RAD51L3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAD51 Paralog D1 2     RAD51 Homolog D2 3
RAD51L31 2 3 5     RAD51-Like Protein 32 3
DNA Repair Protein RAD51 Homolog 41 2     RAD51 (S. Cerevisiae)-Like 31
Recombination Repair Protein1 2     RAD51 Homolog D (S. Cerevisiae)1
R51H32 3     RAD51-Like 3 (S. Cerevisiae)1
TRAD2 3     BROVCA42

External Ids:    HGNC: 98231   Entrez Gene: 58922   Ensembl: ENSG000001853797   OMIM: 6029545   UniProtKB: O757713   
ORGUL members:         
NONCODE14:n410546 n410544 n410545 n410547      

Export aliases for RAD51D gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD51D Gene:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar
to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous
recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family,
including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze
homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of
recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through
transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1
(RFFL) gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for RAD51D Gene: 
RAD51D (RAD51 paralog D) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with RAD51D include rad51d-related familial susceptibility to breast-ovarian cancer, and hereditary pancreatitis, and among its related super-pathways are Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity and ATP binding. An important paralog of this gene is ENSG00000267618.

UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA,
single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

Gene Wiki entry for RAD51D (RAD51L3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RAD51D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51D promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD51D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD51D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11

RAD51D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033427:  view genomic region     (about GC identifiers)

Start:
33,426,811 bp from pter      End:
33,448,541 bp from pter
Size:
21,731 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RAD51D

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 4  
Size: 328 amino acids; 35049 Da
Subunit: Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination
repair
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for RAD51D:
2KZ3 (3D)    
Secondary accessions: B4DJU7 E1P637 O43537 O60355 O75196 O75847 O75848 O76073 O76085 O94908
Q9UFU5
Alternative splicing: 8 isoforms:  O75771-1   O75771-2   O75771-3   O75771-4   O75771-5   O75771-6   O75771-7   O75771-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD51D: NX_O75771

Explore proteomics data for RAD51D at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75771

  • RAD51D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAD51D Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001136043.1  NP_002869.3  NP_598332.1  

    ENSEMBL proteins: 
     ENSP00000338790   ENSP00000378090   ENSP00000468764   ENSP00000465366   ENSP00000338408  
     ENSP00000465584   ENSP00000466587   ENSP00000466399   ENSP00000465612   ENSP00000466478  
     ENSP00000466839   ENSP00000465033   ENSP00000465007   ENSP00000468724   ENSP00000468273  
     ENSP00000468324   ENSP00000353417   ENSP00000464356   ENSP00000350581  

    Human Recombinant Protein Products for RAD51D: 
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    Novus Biologicals RAD51D Protein
    Novus Biologicals RAD51D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    RAD51D for ontologies           About GeneDecksing



    RAD51D Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR020588 DNA_recomb_RecA/RadB_ATP-bd
     IPR016467 DNA_recomb/repair_RecA-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O75771

    ProtoNet protein and cluster: O75771

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Similarity: Belongs to the RecA family. RAD51 subfamily


    RAD51D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RA51D_HUMAN, O75771
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
    during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA,
    single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding IEA--
    GO:0003678DNA helicase activity ----
    GO:0005515protein binding IPI10749867
    GO:0005524ATP binding IEA--
         
    RAD51D for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD51D:
     Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad51d):
     cardiovascular system  cellular  embryogenesis  growth/size  limbs/digits/tail 
     mortality/aging  nervous system 

    RAD51D for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Rad51dtm1Jcs for RAD51D

       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAD51D 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAD51D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD51D 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD51D 

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAD51D About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40
    2Meiosis
    Meiosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAD51D
        Meiosis



    1         Kegg Pathway  (Kegg details for RAD51D):
        Homologous recombination


    RAD51D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAD51D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for RAD51D (O757711, 2, 3 ENSP000003780904) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC2O435432, 3, ENSP000003522714MINT-2730528 MINT-18212 I2D: score=4 STRING: ENSP00000352271
    EFHD2Q96C192, 3, ENSP000003651474MINT-2730588 I2D: score=1 STRING: ENSP00000365147
    BLMP541323, ENSP000003472324I2D: score=3 STRING: ENSP00000347232
    DCDP816053, ENSP000002933714I2D: score=2 STRING: ENSP00000293371
    RAD51CO435023, ENSP000003367014I2D: score=2 STRING: ENSP00000336701
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006260DNA replication ----
    GO:0006281DNA repair IEA--
    GO:0007131reciprocal meiotic recombination TAS9570954

    RAD51D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD51D (RA51D)

    Search CenterWatch for drugs/clinical trials and news about RAD51D / RA51D

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAD51D gene (6 alternative transcripts): 
    NM_001142571.1  NM_002878.3  NM_133629.2  NM_133627.1  NM_133628.1  NM_133630.1  

    Unigene Cluster for RAD51D:

    RAD51 homolog D (S. cerevisiae)
    Hs.631757  [show with all ESTs]
    Unigene Representative Sequence: NM_001142571
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000345365(uc002hir.2 uc002hit.2 uc010ctk.2) ENST00000394589(uc010wce.1 uc010wcd.1 uc002hiw.1 uc010ctl.1)
    ENST00000588372 ENST00000588594 ENST00000335858(uc010ctj.2 uc002his.2)
    ENST00000586044 ENST00000587977 ENST00000590016 ENST00000586210 ENST00000590380
    ENST00000587405 ENST00000592577 ENST00000590631 ENST00000415064(uc010wcf.1 uc010ctm.1)
    ENST00000587982 ENST00000592430 ENST00000585947 ENST00000585982
    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
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    Clone
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    Sirion Biotech Customized lentivirus for stable overexpression of RAD51D 
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    Additional mRNA sequence: 

    AB013341.1 AB016225.1 AB018360.1 AB018361.1 AB018362.1 AB018363.1 AB020412.1 AF034956.1 
    AK296241.1 AK301249.1 AL117459.1 BC002723.2 BC014422.1 BX647297.1 NR_037711.1 NR_037712.1 
    Y15572.1 

    12 DOTS entries:

    DT.120964034  DT.40299610  DT.100816286  DT.100816283  DT.95166746  DT.40281551  DT.70102785  DT.75164409 
    DT.100025408  DT.92026831  DT.95112345  DT.120964097 

    24/183 AceView cDNA sequences (see all 183):

    BC002723 AB016223 BM739302 AW297309 AY098935 BG059956 AI033521 NM_133629 
    BM915550 AK093112 AI760772 BI850594 BC014422 BX647297 BU521767 AB013341 
    AB018360 AW300373 AI692982 BG060070 BM759246 AB016224 BU508016 BU681257 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51D (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                  -           -                                                               
    SP2:                                            -     -           -                                                               
    SP3:                                                  -     -     -                                                               
    SP4:                                            -     -           -     -     -                                                   
    SP5:                                            -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for RAD51D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD51D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGACTG
    RAD51D Expression
    About this image


    See RAD51D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD51D

    SOURCE GeneReport for Unigene cluster: Hs.631757

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Tissue specificity: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly
    expressed in leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including RAD51D: 
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD51D gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad51d5
    Rad51l31
    RAD51-like 3 (S. cerevisiae)1, 5 83.23(n)1
    83.23(a)1
      11 (50.30 cM)5
    193641  NM_011235.31  NP_035365.11 
     828764345 
    chicken
    (Gallus gallus)
    Aves RAD51D1 RAD51 homolog D (S. cerevisiae) 68.65(n)
    67.71(a)
      417528  NM_001198646.1  NP_001185575.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.190612 Transcribed sequence with weak similarity to protein more 69.05(n)    CD759154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad51C6
    Rad51C
    21(a)
    1 ↔ 1
    2R(5053240-5054371)
    worm
    (Caenorhabditis elegans)
    Secernentea rad-516
    Protein RAD-51, isoform a
    17(a)
    1 → many
    IV(10281637-10284244)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD516
    Strand exchange protein, forms a helical filament ...
    17(a)
    1 → many
    V(349980-351182)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD51D1 DNA repair protein RAD51-like 4 44.79(n)
    35.16(a)
      837289  NM_100649.2  NP_172254.2 


    ENSEMBL Gene Tree for RAD51D (if available)
    TreeFam Gene Tree for RAD51D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD51D gene
    ENSG000002676182  
    1 SIMAP similar gene for RAD51D using alignment to 8 protein entries:     RA51D_HUMAN (see all proteins):
    RAD51L3

    RAD51D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/517 SNPs in RAD51D are shown (see all 517)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760824211,2
    C--29614142(+) TTTTTA/TATTTT 5 -- int10--------
    rs283632761,2
    C,F--29617735(-) GTCACAT/-GAGTT 5 -- int11Minor allele frequency- -:0.01NS 170
    rs605539441,2
    C--33436999(+) TTTTTTTTT/-  
            
    GAGAT
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs1497117631,2
    --33488752(+) TGTGCA/CCGATT 5 -- ds50010--------
    rs1478280791,2
    --33488816(+) ATTTGA/CAATTT 5 -- ds50010--------
    rs1423886581,2
    --33488904(+) TTTCTC/TCTGAG 5 -- ds50010--------
    rs110803201,2
    C,F,A,H--33488950(+) GCTTAG/AGCTTA 5 -- ds50015Minor allele frequency- A:0.00NS EA NA 420
    rs98912301,2
    C,F,H--33489032(+) CTGTTG/TCATTC 5 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs752919471,2
    C--33489047(+) CCTCTA/CAATGT 5 -- ds50010--------
    rs779777961,2
    C--33489048(+) CTCTAA/GATGTC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAD51D (33426811 - 33448541 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAD51D: --

    Human Gene Mutation Database (HGMD): RAD51D
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD51D
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD51D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602954    OMIM disorders: --

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
  • Familial breast-ovarian cancer 4 (BROVCA4) [MIM:614291]: A condition associated with familial
    predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age
    of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in
    both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased
    incidence of tumors of other specific organs, such as the prostate. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • 15 diseases for RAD51D:    About MalaCards
    rad51d-related familial susceptibility to breast-ovarian cancer    hereditary pancreatitis    familial breast cancer    bloom syndrome
    fanconi's anemia    anemia    ovarian cancer    kaposi's sarcoma
    multiple sclerosis    pancreatic cancer    pancreatitis    breast cancer
    sarcoma    colorectal cancer    prostatitis


    RAD51D for disorders           About GeneDecksing


    Export disorders for RAD51D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD51D gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with RAD51D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PubMed id 9570954)1, 2, 3, 9 Pittman D.L.... Schimenti J.C. (1998)
    2. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. (PubMed id 9512535)1, 2, 9 Cartwright R.... Thacker J. (1998)
    3. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (2002)
    4. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (2002)
    5. Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family. (PubMed id 10092526)1, 2, 9 Kawabata M. and Saeki K. (1999)
    6. Structural and functional characterization of the N-t erminal domain of human Rad51D. (PubMed id 21111057)1, 2 Kim Y.M. and Choi B.S. (2011)
    7. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PubMed id 21965664)1, 2 Liu T.... Huang J. (2011)
    8. Germline mutations in RAD51D confer susceptibility to ovarian cancer. (PubMed id 21822267)1, 2 Loveday C.... Rahman N. (2011)
    9. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PubMed id 16710300)1, 2 Martin V.... Russell P. (2006)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5892 HGNC: 9823 AceView: RAD51L3andRFFL Ensembl:ENSG00000185379 euGenes: HUgn5892
    ECgene: RAD51D Kegg: 5892 H-InvDB: RAD51D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD51D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD51D Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51l3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAD51D gene:
    Search GeneIP for patents involving RAD51D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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