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RAD51D Gene

protein-coding   GIFtS: 52
GCID: GC17M033427

RAD51 Paralog D

(Previous names: RAD51 (S. cerevisiae)-like 3, RAD51-like 3 (S. cerevisiae),...)
(Previous symbol: RAD51L3)
  See RAD51D-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD51 Paralog D1 2     RAD51 Homolog D2 3
RAD51L31 2 3 5     RAD51-Like Protein 32 3
DNA Repair Protein RAD51 Homolog 41 2     BROVCA42 5
Recombination Repair Protein1 2     RAD51 (S. Cerevisiae)-Like 31
R51H32 3     RAD51 Homolog D (S. Cerevisiae)1
TRAD2 3     RAD51-Like 3 (S. Cerevisiae)1

External Ids:    HGNC: 98231   Entrez Gene: 58922   Ensembl: ENSG000001853797   OMIM: 6029545   UniProtKB: O757713   

Export aliases for RAD51D gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD51D Gene:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar
to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous
recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family,
including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze
homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of
recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through
transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1
(RFFL) gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for RAD51D Gene:
RAD51D (RAD51 paralog D) is a protein-coding gene. Diseases associated with RAD51D include breast-ovarian cancer, familial 4, and rad51d-related familial susceptibility to breast-ovarian cancer. GO annotations related to this gene include DNA-dependent ATPase activity. An important paralog of this gene is ENSG00000267618.

UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA,
single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

Gene Wiki entry for RAD51D (RAD51L3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RAD51D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51D promoter sequence
   Search Chromatin IP Primers for RAD51D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD51D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11

RAD51D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033427:  view genomic region     (about GC identifiers)

Start:
33,426,811 bp from pter      End:
33,448,541 bp from pter
Size:
21,731 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for RAD51D

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 4  
Size: 328 amino acids; 35049 Da
Subunit: Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination
repair
1 PDB 3D structure from and Proteopedia for RAD51D:
2KZ3 (3D)    
Secondary accessions: B4DJU7 E1P637 O43537 O60355 O75196 O75847 O75848 O76073 O76085 O94908
Q9UFU5
Alternative splicing: 8 isoforms:  O75771-1   O75771-2   O75771-3   O75771-4   O75771-5   O75771-6   O75771-7   O75771-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD51D: NX_O75771

Explore proteomics data for RAD51D at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAD51D Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001136043.1  NP_002869.3  NP_598332.1  

    ENSEMBL proteins: 
     ENSP00000338790   ENSP00000378090   ENSP00000468764   ENSP00000465366   ENSP00000338408  
     ENSP00000465584   ENSP00000466587   ENSP00000466399   ENSP00000465612   ENSP00000466478  
     ENSP00000466839   ENSP00000465033   ENSP00000465007   ENSP00000468724   ENSP00000468273  
     ENSP00000468324   ENSP00000353417   ENSP00000464356   ENSP00000350581  

    RAD51D Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for RAD51D
    OriGene Custom MassSpec
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    Novus Biologicals RAD51D Protein
    Novus Biologicals RAD51D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for RAD51D 

    RAD51D Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD51D
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    Abcam antibodies for RAD51D
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for RAD51D
    LSBio Antibodies in human, mouse, rat for RAD51D

    RAD51D Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RAD51D
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for RAD51D 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR020588 RecA_ATP-bd
     IPR016467 DNA_recomb/repair_RecA-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O75771

    ProtoNet protein and cluster: O75771

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Similarity: Belongs to the RecA family. RAD51 subfamily


    Find genes that share domains with RAD51D           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RA51D_HUMAN, O75771
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
    during DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA,
    single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000400contributes to four-way junction DNA binding IDA--
    GO:0003677DNA binding TAS9570954
    GO:0003678DNA helicase activity ----
    GO:0003697single-stranded DNA binding IDA10871607
         
    Find genes that share ontologies with RAD51D           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD51D:
     Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad51d):
     cardiovascular system  cellular  embryogenesis  growth/size/body  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  nervous system 

    Find genes that share phenotypes with RAD51D           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad51dtm1Jcs for RAD51D

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD51D
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD51D

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD51D
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD51D

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAD51D:
    hsa-mir-324-5p (MIRT043149), hsa-mir-26b-5p (MIRT029789), hsa-mir-615-3p (MIRT040122)

    Block miRNA regulation of human, mouse, rat RAD51D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD51D
    Predesigned siRNA for gene silencing in human, mouse, rat RAD51D

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RAD51D
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for RAD51D
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51D
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51D

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD51D 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RA51D_HUMAN, O75771: Nucleus (Probable)

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000781chromosome, telomeric region IDA15109494
    GO:0005634nucleus TAS9570954
    GO:0005657replication fork IDA--
    GO:0005813centrosome IDA--
    GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex IDA11751635

    Find genes that share ontologies with RAD51D           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD51D About    
    See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40
    2Meiosis (EMD)
    Meiosis


    Find genes that share SuperPaths with RAD51D           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for RAD51D):
        Homologous recombination

        Pathway & Disease-focused RT2 Profiler PCR Array including RAD51D: 
              DNA Repair in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for RAD51D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD51D (O757711, 2, 3 ENSP000003780904) via UniProtKB, MINT, STRING, and/or I2D (see all 226)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EFHD2Q96C192, 3, ENSP000003651474MINT-2730588 I2D: score=1 STRING: ENSP00000365147
    XRCC2O435431, 2, 3, ENSP000003522714EBI-1055693,EBI-3918457 MINT-2730528 MINT-18212 I2D: score=4 STRING: ENSP00000352271
    BLMP541323, ENSP000003472324I2D: score=3 STRING: ENSP00000347232
    RAD51CO435023, ENSP000003367014I2D: score=2 STRING: ENSP00000336701
    RADILQ96JH83, ENSP000003824924I2D: score=2 STRING: ENSP00000382492
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000723telomere maintenance IMP15109494
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0006200ATP catabolic process IDA10871607
    GO:0006259DNA metabolic process ----
    GO:0006260DNA replication ----

    Find genes that share ontologies with RAD51D           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD51D (RA51D)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD51D gene (6 alternative transcripts): 
    NM_001142571.1  NM_002878.3  NM_133629.2  NM_133627.1  NM_133628.1  NM_133630.1  

    Unigene Cluster for RAD51D:

    RAD51 homolog D (S. cerevisiae)
    Hs.631757  [show with all ESTs]
    Unigene Representative Sequence: NM_001142571
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000345365(uc002hir.2 uc002hit.2 uc010ctk.2) ENST00000394589(uc010wce.1 uc010wcd.1 uc002hiw.1 uc010ctl.1)
    ENST00000588372 ENST00000588594 ENST00000335858(uc010ctj.2 uc002his.2)
    ENST00000586044 ENST00000587977 ENST00000590016 ENST00000586210 ENST00000590380
    ENST00000587405 ENST00000592577 ENST00000590631 ENST00000415064(uc010wcf.1 uc010ctm.1)
    ENST00000587982 ENST00000592430 ENST00000585947 ENST00000585982
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAD51D using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for RAD51D
    Predesigned siRNA for gene silencing in human, mouse, rat RAD51D
    Clone
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    Primer
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    OriGene qPCR primer pairs and template standards for RAD51D
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD51D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD51D
      QuantiTect SYBR Green Assays in human, mouse, rat RAD51D
      QuantiFast Probe-based Assays in human, mouse, rat RAD51D

    Additional mRNA sequence: 

    AB013341.1 AB016225.1 AB018360.1 AB018361.1 AB018362.1 AB018363.1 AB020412.1 AF034956.1 
    AK296241.1 AK301249.1 AL117459.1 BC002723.2 BC014422.1 BX647297.1 NR_037711.1 NR_037712.1 
    Y15572.1 

    12 DOTS entries:

    DT.120964034  DT.40299610  DT.100816286  DT.100816283  DT.95166746  DT.40281551  DT.70102785  DT.75164409 
    DT.100025408  DT.92026831  DT.95112345  DT.120964097 

    Selected AceView cDNA sequences (see all 183):

    BG059956 AI597891 BU681257 BM670107 BU521767 AW297309 BC014422 BM696809 
    BE349405 BM476849 NM_133630 AW296494 CD368674 NM_133629 AI033521 AB016225 
    AB013341 NM_133627 AI760772 AB018360 AB018362 BG059954 BM739302 BM915550 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD51D (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                  -           -                                                               
    SP2:                                            -     -           -                                                               
    SP3:                                                  -     -     -                                                               
    SP4:                                            -     -           -     -     -                                                   
    SP5:                                            -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for RAD51D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD51D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGACTG
    RAD51D Expression
    About this image

    RAD51D Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD51D Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631757

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Tissue specificity: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly
    expressed in leukocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including RAD51D: 
              DNA Repair in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RAD51D
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD51D
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD51D
    QuantiTect SYBR Green Assays in human, mouse, rat RAD51D
    QuantiFast Probe-based Assays in human, mouse, rat RAD51D
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD51D gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad51d1 , 5 RAD51-like 3 (S. cerevisiae)5
    RAD51 homolog D1
    83.23(n)1
    83.23(a)1
      11 (50.30 cM)5
    193641  NM_011235.41  NP_035365.11 
     828764345 
    chicken
    (Gallus gallus)
    Aves RAD51D1 RAD51 homolog D (S. cerevisiae) 69.31(n)
    69.21(a)
      417528  NM_001198646.1  NP_001185575.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia rad51d1 RAD51 paralog D 62.55(n)
    57.91(a)
      448189  NM_001005687.1  NP_001005687.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.190612 Transcribed sequence with weak similarity to protein more 69.05(n)    CD759154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad51C6
    Rad51C
    24(a)
    1 → many
    2R(5053240-5054371)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD51D1 RAD51D 44.79(n)
    35.16(a)
      837289  NM_100649.2  NP_172254.2 


    ENSEMBL Gene Tree for RAD51D (if available)
    TreeFam Gene Tree for RAD51D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD51D gene
    ENSG000002676182  
    1 SIMAP similar gene for RAD51D using alignment to 8 protein entries:     RA51D_HUMAN (see all proteins):
    RAD51L3

    Find genes that share paralogs with RAD51D           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD51D (see all 517)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs760824211,2
    C--29614142(+) TTTTTA/TATTTT 5 -- int10--------
    rs283632761,2
    C,F--29617735(-) GTCACAT/-GAGTT 5 -- int11Minor allele frequency- -:0.01NS 170
    rs605539441,2
    C--33436999(+) TTTTTTTTT/-  
            
    GAGAT
    5 -- int11Minor allele frequency- -:0.00NA 2
    rs1497117631,2
    --33488752(+) TGTGCA/CCGATT 5 -- ds50010--------
    rs1478280791,2
    --33488816(+) ATTTGA/CAATTT 5 -- ds50010--------
    rs1423886581,2
    --33488904(+) TTTCTC/TCTGAG 5 -- ds50010--------
    rs110803201,2
    C,F,A,H--33488950(+) GCTTAG/AGCTTA 5 -- ds50015Minor allele frequency- A:0.00NS EA NA 420
    rs98912301,2
    C,F,H--33489032(+) CTGTTG/TCATTC 5 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs752919471,2
    C--33489047(+) CCTCTA/CAATGT 5 -- ds50010--------
    rs779777961,2
    C--33489048(+) CTCTAA/GATGTC 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for RAD51D (33426811 - 33448541 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAD51D: --
    Human Gene Mutation Database (HGMD): RAD51D
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD51D
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD51D

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602954   
    OMIM disorders: 614291  
    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
  • Breast-ovarian cancer, familial, 4 (BROVCA4) [MIM:614291]: A condition associated with familial
    predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age
    of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in
    both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased
    incidence of tumors of other specific organs, such as the prostate. Note=Disease susceptibility is associated
    with variations affecting the gene represented in this entry

  • 5 diseases for RAD51D:    
    About MalaCards
    breast-ovarian cancer, familial 4    rad51d-related familial susceptibility to breast-ovarian cancer    acral lentiginous melanoma    breast-ovarian cancer, familial, 2
    ovarian cancer


    Find genes that share disorders with RAD51D           About GenesLikeMe


    Export disorders for RAD51D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD51D gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with RAD51D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PubMed id 9570954)1, 2, 3, 9 Pittman D.L.... Schimenti J.C. (Genomics 1998)
    2. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. (PubMed id 9512535)1, 2, 9 Cartwright R.... Thacker J. (Nucleic Acids Res. 1998)
    3. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (Nucleic Acids Res. 2002)
    4. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (J. Biol. Chem. 2002)
    5. Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family. (PubMed id 10092526)1, 2, 9 Kawabata M. and Saeki K. (Biochem. Biophys. Res. Commun. 1999)
    6. Structural and functional characterization of the N-terminal domain of human Rad51D. (PubMed id 21111057)1, 2 Kim Y.M. and Choi B.S. (Int. J. Biochem. Cell Biol. 2011)
    7. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PubMed id 21965664)1, 2 Liu T.... Huang J. (J. Biol. Chem. 2011)
    8. Germline mutations in RAD51D confer susceptibility to ovarian cancer. (PubMed id 21822267)1, 2 Loveday C.... Rahman N. (Nat. Genet. 2011)
    9. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PubMed id 16710300)1, 2 Martin V.... Russell P. (EMBO J. 2006)
    10. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (Genome Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5892 HGNC: 9823 AceView: RAD51L3andRFFL Ensembl:ENSG00000185379 euGenes: HUgn5892
    ECgene: RAD51D Kegg: 5892 H-InvDB: RAD51D

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD51D Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD51D Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51l3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD51D gene:
    Search GeneIP for patents involving RAD51D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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