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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD51D Gene

protein-coding   GIFtS: 54
GCID: GC17M033427

RAD51 homolog D (S. cerevisiae)

(Previous names: RAD51 (S. cerevisiae)-like 3, RAD51-like 3 (S. cerevisiae)...)
(Previous symbol: RAD51L3)
 Explore 12 diseases affiliated with
RAD51D via our new
 Human Malady Compendium 
Biological research products
for RAD51D
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAD51 Homolog D (S. Cerevisiae)1 2     RAD51 (S. Cerevisiae)-Like 31
RAD51L31 2 3 5     RAD51-Like 3 (S. Cerevisiae)1
R51H31 2 3     BROVCA42
TRAD2 3     DNA Repair Protein RAD51 Homolog 42
RAD51-Like Protein 32 3     Recombination Repair Protein2
HsTRAD1     RAD51 Homolog D3
Trad1     

External Ids:    HGNC: 98231   Entrez Gene: 58922   Ensembl: ENSG000001853797   OMIM: 6029545   UniProtKB: O757713   
ORGUL members:         
NONCODE:n410544 n410545    

Export aliases for RAD51D gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD51D:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to
bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and
repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1,
RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between
single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA.
Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene
and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during
DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps
in duplex DNA and specifically to nicks in duplex DNA

Gene Wiki entry for RAD51D (RAD51L3)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010799.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for RAD51D
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51D promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD51D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD51D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11

RAD51D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51D gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M033427:  view genomic region     (about GC identifiers)

Start:
33,426,811 bp from pter      End:
33,448,541 bp from pter
Size:
21,731 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

  • n410545
  • n410544
33426810 33436849 33446888 chr17

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 4  
Size: 328 amino acids; 35049 Da
Subunit: Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of
RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair
Subcellular location: Nucleus (Probable)
1 PDB 3D structure from and Proteopedia for RAD51D:
2KZ3 (3D)    
Secondary accessions: B4DJU7 E1P637 O43537 O60355 O75196 O75847 O75848 O76073 O76085 O94908 Q9UFU5
Alternative splicing: 8 isoforms:  O75771-1   O75771-2   O75771-3   O75771-4   O75771-5   O75771-6   O75771-7   O75771-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD51D: NX_O75771

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75771

  • RAD51D Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001136043.1  NP_002869.3  NP_598332.1  

    ENSEMBL proteins: 
     ENSP00000338790   ENSP00000378090   ENSP00000468764   ENSP00000465366   ENSP00000338408  
     ENSP00000465584   ENSP00000466587   ENSP00000466399   ENSP00000465612   ENSP00000466478  
     ENSP00000466839   ENSP00000465033   ENSP00000465007   ENSP00000468724   ENSP00000468273  
     ENSP00000468324   ENSP00000353417   ENSP00000464356   ENSP00000350581  

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    OriGene Protein Over-expression Lysate (see all 2): RAD51D
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    Novus Biologicals RAD51D Protein
    Novus Biologicals RAD51D Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAD51D

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    RAD51D for ontologies           About GeneDecksing



    RAD51D Antibody Products: 
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    Uscn ELISAs and CLIAs for RAD51D


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    RAD51D for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR020588 DNA_recomb_RecA/RadB_ATP-bd
     IPR016467 DNA_recomb/repair_RecA-like
     IPR003593 AAA+_ATPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O75771

    ProtoNet protein and cluster: O75771

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Similarity: Belongs to the RecA family. RAD51 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during
    DNA replication or induced by DNA-damaging agents. The BCDX2 complex binds single-stranded DNA, single-stranded gaps
    in duplex DNA and specifically to nicks in duplex DNA

    miRNA
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    OriGene 3'-UTR Clone (see all 3): RAD51D
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD51D
    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD51D (see all 4)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008094DNA-dependent ATPase activity IEA--


    RAD51D for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for RAD51D:
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Rad51dtm1Jcs for RAD51D
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Rad51d):
     cardiovascular system  cellular  embryogenesis  growth/size  limbs/digits/tail 
     mortality/aging  nervous system 

    RAD51D for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Meiosis
    Meiosis1.00
    2Homologous recombination
    Homologous recombination0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for RAD51D
        Meiosis



    1         Kegg Pathway  (Kegg details for RAD51D):
        Homologous recombination


    RAD51D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAD51D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/16 Interacting proteins for RAD51D (O757711, 2, 3 ENSP000003780904) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    XRCC2O435432, 3, ENSP000003522714MINT-2730528 MINT-18212 I2D: score=4 STRING: ENSP00000352271
    EFHD2Q96C192, 3, ENSP000003651474MINT-2730588 I2D: score=1 STRING: ENSP00000365147
    BLMP541323, ENSP000003472324I2D: score=3 STRING: ENSP00000347232
    DCDP816053, ENSP000002933714I2D: score=2 STRING: ENSP00000293371
    RAD51CO435023, ENSP000003367014I2D: score=2 STRING: ENSP00000336701
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IEA--
    GO:0007131reciprocal meiotic recombination TAS9570954


    RAD51D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD51D
    Search CenterWatch for drugs/clinical trials and news about RAD51D / RA51D 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAD51D gene (6 alternative transcripts): 
    NM_001142571.1  NM_002878.3  NM_133629.2  NM_133627.1  NM_133628.1  NM_133630.1  

    Unigene Cluster for RAD51D:

    RAD51 homolog D (S. cerevisiae)
    Hs.631757  [show with all ESTs]
    Unigene Representative Sequence: NM_001142571
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000345365(uc002hir.2 uc002hit.2 uc010ctk.2) ENST00000394589(uc010wce.1 uc010wcd.1 uc002hiw.1 uc010ctl.1)
    ENST00000588372 ENST00000588594 ENST00000335858(uc010ctj.2 uc002his.2)
    ENST00000586044 ENST00000587977 ENST00000590016 ENST00000586210 ENST00000590380
    ENST00000587405 ENST00000592577 ENST00000590631 ENST00000415064(uc010wcf.1 uc010ctm.1)
    ENST00000587982 ENST00000592430 ENST00000585947 ENST00000585982

    miRNA
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    8/23 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD51D (see all 23):
    hsa-miR-1287 hsa-miR-448 hsa-miR-4318 hsa-miR-188-5p hsa-miR-218-2* hsa-miR-485-3p hsa-miR-944 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidRAD51D 3' UTR sequence
    Inhib. RNA
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD51D
    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD51D
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD51D

    Additional cDNA sequence: 

    AB013341.1 AB016225.1 AB018360.1 AB018361.1 AB018362.1 AB018363.1 AB020412.1 AF034956.1 
    AK296241.1 AK301249.1 AL117459.1 BC002723.2 BC014422.1 BX647297.1 NR_037711.1 NR_037712.1 
    Y15572.1 

    12 DOTS entries:

    DT.120964034  DT.40299610  DT.100816286  DT.100816283  DT.95166746  DT.40281551  DT.70102785  DT.75164409 
    DT.100025408  DT.92026831  DT.95112345  DT.120964097 

    24/183 AceView cDNA sequences (see all 183):

    AB018362 AW297309 BG059956 AB020412 BX327473 AI692982 AW300373 BM696809 
    AY098935 AI242571 AB016225 AK097811 BM915550 BU786480 AF434816 BX647297 
    BQ027317 BM759246 AB018360 NM_133629 AL117459 AI760772 BC015681 AA282406 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51D (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                                  -           -                                                               
    SP2:                                            -     -           -                                                               
    SP3:                                                  -     -     -                                                               
    SP4:                                            -     -           -     -     -                                                   
    SP5:                                            -     -     -     -     -     -                                                   


    ECgene alternative splicing isoforms for RAD51D

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD51D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCGACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See RAD51D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD51D

    SOURCE GeneReport for Unigene cluster: Hs.631757

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
    Tissue specificity: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed
    in leukocytes

        SABiosciences Expression via Pathway-Focused PCR Array including RAD51D: 
              DNA Repair in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD51D gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves RAD51D1 RAD51 homolog D (S. cerevisiae) 68.65(n)
    67.71(a)
      417528  NM_001198646.1  NP_001185575.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.190612 Transcribed sequence with weak similarity to protein more 69.05(n)    CD759154.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad51C6
    Rad51C
    23(a)
    1 ↔ 1
    2R(5053240-5054371)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD51D1 DNA repair protein RAD51-like 4 44.79(n)
    35.16(a)
      837289  NM_100649.2  NP_172254.2 
    rice
    (Oryza sativa)
    Liliopsida --
    DNA repair protein RAD51 homolog 4, putative, expr...
    27(a)
    1 ↔ 1
    9(484012-489816)


    ENSEMBL Gene Tree for RAD51D (if available)
    TreeFam Gene Tree for RAD51D (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD51D gene
    RAD512  RAD51B2  RAD51C2  
    1 SIMAP similar gene for RAD51D using alignment to 8 protein entries:     RA51D_HUMAN (see all proteins):
    RAD51L3

    RAD51D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/400 NCBI SNPs in RAD51D are shown (see all 400    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs110803201,2
    C,F,A,H--29611244(+) GCTTAG/AGCTTA 5 -- ds50015Minor allele frequency- A:0.00NS EA NA 420
    rs98912301,2
    C,H,--29611326(+) CTGTTG/TCATTC 5 -- ds50015Minor allele frequency- T:0.00NS EA 596
    rs116501611,2
    C,H--29611603(+) CACTAG/AGGCAC 5 -- ut31 nc-transcript-variantese34Minor allele frequency- A:0.00NS EA 418
    rs283632961,2
    C,--29611931(-) AGAACG/ATGTGG 5 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.04NS WA 296
    rs283632951,2
    C--29612174(-) ACTCTT/CCCTTA 5 -- ut31 nc-transcript-variant3Minor allele frequency- C:0.01NS NA 168
    rs283632941,2
    C,F,H,--29612268(-) CAGTGG/ACCAAG 5 -- ut31 nc-transcript-variant7Minor allele frequency- A:0.07NS NA 956
    rs283632931,2
    C,F,H,--29612274(-) CTAGCG/ACAGTG 5 -- ut31 nc-transcript-variantese311Minor allele frequency- A:0.08NS NA CSA WA 1437
    rs454940011,2
    C,--29612535(-) CAGACG/ATTCTC 5 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.01NA 120
    rs283632911,2
    C--29612536(-) ACAGAC/TGTTCT 5 -- ut31 nc-transcript-variantese33Minor allele frequency- T:0.01NS NA 184
    rs99141091,2
    C,F,H,--29612828(+) ATCTGT/CGGGTA 5 -- int16Minor allele frequency- C:0.02NS EA WA 716

    HapMap Linkage Disequilibrium report for RAD51D (33426811 - 33448541 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAD51D: --
    Human Gene Mutation Database (HGMD): RAD51D

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD51D
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    RAD51D for disorders           About GeneDecksing

    OMIM gene information: 602954    OMIM disorders: --

    UniProtKB/Swiss-Prot: RA51D_HUMAN, O75771
  • Defects in RAD51D are a cause of susceptibility to familial breast-ovarian cancer type 4 (BROVCA4)
  • [MIM:614291]. A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic
    features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of
    bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast
    cancer among men, increased incidence of tumors of other specific organs, such as the prostate

    12 diseases for RAD51D:    About MalaCards
    bloom syndrome    breast-ovarian cancer    fanconi's anemia    familial breast cancer
    hereditary pancreatitis    multiple sclerosis    ovarian cancer    breast cancer
    anemia    pancreatitis    pancreatic cancer    prostatitis


    Export disorders for RAD51D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD51D gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with RAD51D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PubMed id 9570954)1, 2, 3, 9 Pittman D.L.... Schimenti J.C. (1998)
    2. Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family. (PubMed id 9512535)1, 2, 9 Cartwright R.... Thacker J. (1998)
    3. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (2002)
    4. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (2002)
    5. Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family. (PubMed id 10092526)1, 2, 9 Kawabata M. and Saeki K. (1999)
    6. Structural and functional characterization of the N-t erminal domain of human Rad51D. (PubMed id 21111057)1, 2 Kim Y.M. and Choi B.S. (2011)
    7. Germline mutations in RAD51D confer susceptibility to ovarian cancer. (PubMed id 21822267)1, 2 Loveday C.... Rahman N. (2011)
    8. Sws1 is a conserved regulator of homologous recombination in eukaryotic cells. (PubMed id 16710300)1, 2 Martin V.... Russell P. (2006)
    9. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5892 HGNC: 9823 AceView: RAD51L3andRFFL Ensembl:ENSG00000185379 euGenes: HUgn5892
    ECgene: RAD51D Kegg: 5892 H-InvDB: RAD51D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD51D Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51l3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAD51D gene:
    Search GeneIP for patents involving RAD51D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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