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Aliases for RAD51D Gene

Aliases for RAD51D Gene

  • RAD51 Paralog D 2 3
  • RAD51L3 3 4 6
  • DNA Repair Protein RAD51 Homolog 4 2 3
  • Recombination Repair Protein 2 3
  • RAD51-Like Protein 3 3 4
  • RAD51 Homolog D 3 4
  • BROVCA4 3 6
  • R51H3 3 4
  • TRAD 3 4
  • RAD51 Homolog D (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae)-Like 3 2
  • RAD51-Like 3 (S. Cerevisiae) 2

External Ids for RAD51D Gene

Previous Symbols for RAD51D Gene

  • RAD51L3

Summaries for RAD51D Gene

Entrez Gene Summary for RAD51D Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for RAD51D Gene

RAD51D (RAD51 Paralog D) is a Protein Coding gene. Diseases associated with RAD51D include breast-ovarian cancer, familial 4 and rad51d-related familial susceptibility to breast-ovarian cancer. Among its related pathways are Homologous recombination. GO annotations related to this gene include DNA-dependent ATPase activity. An important paralog of this gene is ENSG00000267618.

UniProtKB/Swiss-Prot for RAD51D Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene Wiki entry for RAD51D Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51D Gene

Genomics for RAD51D Gene

Genomic Location for RAD51D Gene

Start:
35,092,208 bp from pter
End:
35,121,522 bp from pter
Size:
29,315 bases
Orientation:
Minus strand

Genomic View for RAD51D Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51D Gene

No data available for Regulatory Elements for RAD51D Gene

Proteins for RAD51D Gene

  • Protein details for RAD51D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75771-RA51D_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 4
    Protein Accession:
    O75771
    Secondary Accessions:
    • B4DJU7
    • E1P637
    • O43537
    • O60355
    • O75196
    • O75847
    • O75848
    • O76073
    • O76085
    • O94908
    • Q9UFU5

    Protein attributes for RAD51D Gene

    Size:
    328 amino acids
    Molecular mass:
    35049 Da
    Quaternary structure:
    • Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. In the absence of DNA, the BCDX2 subcomplex XRCC2:RAD51D formed a multimeric ring structure; in the presence of single-stranded DNA it formed a filamentous structure with the ssDNA. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts with BLM; required for stimulation of BLM activity by the BCDX2 subcomplex XRCC2:RAD51D.

    Three dimensional structures from OCA and Proteopedia for RAD51D Gene

    Alternative splice isoforms for RAD51D Gene

neXtProt entry for RAD51D Gene

Proteomics data for RAD51D Gene at MOPED

Post-translational modifications for RAD51D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD51D Gene

Domains for RAD51D Gene

Graphical View of Domain Structure for InterPro Entry

O75771

UniProtKB/Swiss-Prot:

RA51D_HUMAN
Family:
  • Belongs to the RecA family. RAD51 subfamily.:
    • O75771
genes like me logo Genes that share domains with RAD51D: view

No data available for Gene Families for RAD51D Gene

Function for RAD51D Gene

Molecular function for RAD51D Gene

UniProtKB/Swiss-Prot Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM.

Gene Ontology (GO) - Molecular Function for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding TAS 9570954
GO:0003678 DNA helicase activity --
GO:0003697 single-stranded DNA binding IDA 10871607
GO:0005515 protein binding IPI 10749867
genes like me logo Genes that share ontologies with RAD51D: view
genes like me logo Genes that share phenotypes with RAD51D: view

Animal Models for RAD51D Gene

MGI Knock Outs for RAD51D:

miRNA for RAD51D Gene

miRTarBase miRNAs that target RAD51D

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAD51D Gene

Localization for RAD51D Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51D Gene

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.

Gene Ontology (GO) - Cellular Components for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000781 chromosome, telomeric region IDA 15109494
GO:0005634 nucleus TAS 9570954
GO:0005657 replication fork IDA 20207730
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21276791
genes like me logo Genes that share ontologies with RAD51D: view

No data available for Subcellular locations from COMPARTMENTS for RAD51D Gene

Pathways for RAD51D Gene

SuperPathways for RAD51D Gene

Superpath Contained pathways
1 Homologous recombination
genes like me logo Genes that share pathways with RAD51D: view

Pathways by source for RAD51D Gene

1 KEGG pathway for RAD51D Gene

Gene Ontology (GO) - Biological Process for RAD51D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000723 telomere maintenance IMP 15109494
GO:0000724 double-strand break repair via homologous recombination IMP 23149936
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006260 DNA replication --
genes like me logo Genes that share ontologies with RAD51D: view

Transcripts for RAD51D Gene

Unigene Clusters for RAD51D Gene

RAD51 homolog D (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51D Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - -
SP6: -
SP7: - - - -
SP8:
SP9: - - - -
SP10: - -
SP11: - - - - - -

Relevant External Links for RAD51D Gene

GeneLoc Exon Structure for
RAD51D
ECgene alternative splicing isoforms for
RAD51D

Expression for RAD51D Gene

mRNA expression in normal human tissues for RAD51D Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51D Gene

SOURCE GeneReport for Unigene cluster for RAD51D Gene Hs.631757

mRNA Expression by UniProt/SwissProt for RAD51D Gene

O75771-RA51D_HUMAN
Tissue specificity: Expressed in colon, prostate, spleen, testis, ovary, thymus and small intestine. Weakly expressed in leukocytes
genes like me logo Genes that share expressions with RAD51D: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAD51D Gene

Orthologs for RAD51D Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51L3 35
  • 99.19 (n)
  • 99.39 (a)
RAD51L3 36
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51D 35
  • 87 (n)
  • 82.66 (a)
RAD51D 36
  • 71 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 73 (a)
OneToMany
RAD51D 35
  • 87.05 (n)
  • 84.71 (a)
mouse
(Mus musculus)
Mammalia Rad51d 35
  • 83.23 (n)
  • 83.23 (a)
Rad51d 16
Rad51d 36
  • 72 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rad51d 35
  • 83.64 (n)
  • 83.84 (a)
chicken
(Gallus gallus)
Aves RAD51D 35
  • 69.31 (n)
  • 69.21 (a)
RAD51D 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51d 35
  • 62.55 (n)
  • 57.91 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2888 35
zebrafish
(Danio rerio)
Actinopterygii Dr.19061 35
rad51d 35
  • 60.7 (n)
  • 55.25 (a)
rad51d 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Rad51C 36
  • 24 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51D 35
  • 44.79 (n)
  • 35.16 (a)
Species with no ortholog for RAD51D:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51D Gene

ENSEMBL:
Gene Tree for RAD51D (if available)
TreeFam:
Gene Tree for RAD51D (if available)

Paralogs for RAD51D Gene

Paralogs for RAD51D Gene

Selected SIMAP similar genes for RAD51D Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with RAD51D: view

Variants for RAD51D Gene

Sequence variations from dbSNP and Humsavar for RAD51D Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_020560 -
VAR_020561 -
VAR_020562 -
VAR_020563 -
VAR_020564 -

Relevant External Links for RAD51D Gene

HapMap Linkage Disequilibrium report
RAD51D
Human Gene Mutation Database (HGMD)
RAD51D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RAD51D Gene

Disorders for RAD51D Gene

(1) OMIM Diseases for RAD51D Gene (602954)

UniProtKB/Swiss-Prot

RA51D_HUMAN
  • Breast-ovarian cancer, familial, 4 (BROVCA4) [MIM:614291]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO:0000269 PubMed:21822267}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with RAD51D: view

Publications for RAD51D Gene

  1. Identification, characterization, and genetic mapping of Rad51d, a new mouse and human RAD51/RecA-related gene. (PMID: 9570954) Pittman D.L. … Schimenti J.C. (Genomics 1998) 2 3 4 23
  2. Multiple alternative transcripts of the human homologue of the mouse TRAD/R51H3/RAD51D gene, a member of the recA/RAD51 gene family. (PMID: 10092526) Kawabata M. … Saeki K. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. The RAD51 family member, RAD51L3, is a DNA-stimulated ATPase that forms a complex with XRCC2. (PMID: 10871607) Braybrooke J.P. … Hickson I.D. (J. Biol. Chem. 2000) 3 4 23
  4. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PMID: 11744692) Miller K.A. … Albala J.S. (J. Biol. Chem. 2002) 3 4 23
  5. Homologous pairing and ring and filament structure formation activities of the human Xrcc2*Rad51D complex. (PMID: 11834724) Kurumizaka H. … Shibata T. (J. Biol. Chem. 2002) 3 4 23

Products for RAD51D Gene

Sources for RAD51D Gene

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