RAD51C Gene
protein-coding GIFtS: 63
GCID: GC17P056769
|
|
RAD51 homolog C (S. cerevisiae)(Previous name: RAD51 (S. cerevisiae) homolog C )
| |
Aliases
for RAD51C gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| RAD51 Homolog C (S. Cerevisiae)1 2 | | BROVCA32 5 | | RAD51L21 2 3 | | FANCO2 5 | | R51H32 3 | | RAD51 (S. Cerevisiae) Homolog C1 | | RAD51 Homolog C2 3 | | DNA Repair Protein RAD51 Homolog 32 | | RAD51-Like Protein 22 3 | | Yeast RAD51 Homolog 32 |
Export aliases for RAD51C gene to outside databasesPrevious GC identifers: GC17P056517 GC17P059251 GC17P057112 GC17P057244 GC17P054124 GC17P052130 |
Summaries
for RAD51C gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for RAD51C:
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to beinvolved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with twoother DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 proteinin a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair.This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breasttumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumorprogression. Alternative splicing has been observed for this gene and two variants encoding different isoforms havebeen identified. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502Function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologousrecombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced byDNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complexbinds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates inbranch migration and Holliday junction resolution and thus is important for processing HR intermediates late in theDNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinaseCHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrialDNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-linkresistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis
Gene Wiki entry for RAD51C
|
Genomic Views
for RAD51C gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the RAD51C gene promoter:
SREBP-1c Nkx2-5 Tal-1beta SREBP-1b E47 SREBP-1a POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for RAD51C
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD51C |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q22 HGNC cytogenetic band: 17q25.1RAD51C Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P056769: view genomic region
(about GC identifiers)
Start:
|
56,769,934 bp from pter |
End:
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56,811,703 bp from pter |
Size:
|
41,770 bases |
Orientation:
|
plus strand |
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Proteins
for RAD51C gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502 (See
protein sequence)Recommended Name: DNA repair protein RAD51 homolog 3 Size: 376 amino acids; 42190 Da
Subunit: Interacts with RAD51B and XRCC3. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Partof a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51B and RAD51. Interactswith SWSAP1; involved in homologous recombination repair
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces anincrease in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during the Sor G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA
Secondary accessions: O43503 Q3B783Alternative splicing: 2 isoforms: O43502-1 O43502-2 Explore the universe of human proteins at neXtProt for RAD51C: NX_O43502
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43502
RAD51C Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_002867.1 NP_478123.1
ENSEMBL proteins: ENSP00000464056 ENSP00000463121 ENSP00000336701 ENSP00000432421 ENSP00000436761 ENSP00000431637 ENSP00000433332 ENSP00000391450 ENSP00000463473 ENSP00000407282 ENSP00000401741 ENSP00000463658 Reactome Protein details: O43502
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
RAD51C for ontologies About GeneDecksing
RAD51C Antibody Products:
Assay Products for RAD51C: |
Protein
Domains /
Families
for RAD51C gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
RAD51C for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43502ProtoNet protein and cluster: O43502 1 Blocks protein family: IPB013632 Rad51
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502Similarity: Belongs to the RecA family. RAD51 subfamily |
Function
for RAD51C gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502Function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologousrecombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced byDNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complexbinds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates inbranch migration and Holliday junction resolution and thus is important for processing HR intermediates late in theDNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinaseCHEK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrialDNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-linkresistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosisInduction: Stress-induced increase in the mitochondrial levels is seen Genatlas biochemistry entry for RAD51C:yeast (S cerevisiae) RAD51 homolog 3,highly expressed in testis,involved in mitosis and meiotic recombination events
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): RAD51C (NM_002876) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD51C | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51C |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51C |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
RAD51C for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for RAD51C:
Animal Models:
Mouse knock-out Rad51ctm1.1Sks for RAD51C
5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Rad51c):
RAD51C for phenotypes About GeneDecksing
|
Pathways & Interactions
for RAD51C gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiosis | | | 2 | Factors involved in megakaryocyte development and platelet production | | | 3 | Platelet activation, signaling and aggregation | | | 4 | Homologous recombination | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for RAD51C
2 
Reactome Pathways for RAD51C
1 
Kegg Pathway (Kegg details for RAD51C):
RAD51C for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD51C
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/24 Interacting proteins for RAD51C (O435021, 2, 3 ENSP000003367014) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
RAD51C for ontologies About GeneDecksing
|
Drugs & Compounds
for RAD51C gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
RAD51C for compounds About GeneDecksing
 Browse Tocris compounds for RAD51C
1 Novoseek chemical compound relationship for RAD51C gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| camptothecin |
43.8 |
1 |
12584174 (1) |
Search CenterWatch for drugs/clinical trials and news about RAD51C / RA51C
|
Transcripts
for RAD51C gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for RAD51C gene (3 alternative transcripts): NM_002876.2 NM_058216.1 NM_058217.1 Unigene Cluster for RAD51C: RAD51 homolog C (S. cerevisiae) Hs.412587 [show with all ESTs]Unigene Representative Sequence: BC07316117 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000461271(uc010wob.1) ENST00000583539(uc010woa.1) ENST00000337432(uc002iwu.3 uc002iww.3)
ENST00000487921 ENST00000476741 ENST00000475762(uc010ddc.3) ENST00000486827(uc002iwt.1)
ENST00000487525 ENST00000482007 ENST00000421782 ENST00000584617 ENST00000425173
ENST00000413590 ENST00000581221 ENST00000578151 ENST00000584804 ENST00000461706
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): RAD51C (NM_002876) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for RAD51C | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51C |
Additional cDNA sequence: AF029669.1 AF029670.1 AK129738.1 AK290487.1 AK303363.1 BC064578.1 BC073161.1 BC093930.1 BC101485.1 BC107753.1 BC143259.1 BT007339.1 20 DOTS entries: DT.100027246 DT.92434296 DT.95286890 DT.100027245 DT.415025 DT.455920 DT.97844308 DT.70102713 DT.95378440 DT.97769874 DT.120971433 DT.97844306 DT.99947554 DT.120971389 DT.75130816 DT.120971382 DT.120971465 DT.91683507 DT.95200687 DT.40131687 24/181 AceView cDNA sequences (see all 181): CA843435 BC064578 BM563459 AF029669 BG220326 BE252096 BE257856 AI796161 BC000667 AI240932 AA748784 AA909265 BF593234 AI431899 BP873523 CR623930 CB990405 AI350972 BQ431590 BM832934 NM_058216 AI471758 BM987503 AI146809
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51C (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | - | | - | | - | | | | - | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | | | - | | - | | | | | |
ECgene alternative splicing isoforms for RAD51C
|
Expression
for RAD51C gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| RAD51C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See RAD51C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for RAD51C
SOURCE GeneReport for Unigene cluster: Hs.412587
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502Tissue specificity: Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen andprostate
SABiosciences Expression via Pathway-Focused PCR Arrays including RAD51C:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD51C
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAD51C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD51C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD51C | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51C |
Orthologs
for RAD51C gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for RAD51C gene from 7/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
RAD51C1 |
RAD51 homolog C (S. cerevisiae) |
71.51(n)
73.15(a) |
|
417626 XM_415870.3 XP_415870.3 |
lizard
(Anolis carolinensis) |
Reptilia |
RAD51C6 |
-- |
72(a) |
1 ↔ 1 |
AAWZ02040106(2830-5874) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.186912 |
Transcribed sequence with weak similarity to protein more |
70.85(n) |
|
AL856750.2 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.143862 |
Transcribed sequence with weak similarity to protein more |
71.56(n) |
|
BI673100.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
spn-D6 |
spindle D |
28(a) |
1 ↔ 1 |
3R(22991440-22992844) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
RAD51C1 |
DNA repair protein RAD51-like 3 |
49.85(n)
40.98(a) |
|
819136 NM_130091.1 NP_566040.1 |
rice
(Oryza sativa) |
Liliopsida |
Os01g05780001 |
hypothetical protein |
49.75(n)
39.47(a) |
|
4323853 NM_001049929.1 NP_001043394.1 |
ENSEMBL Gene Tree for RAD51C (if available)
TreeFam Gene Tree for RAD51C (if available) |
Paralogs
for RAD51C gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for RAD51C gene
- RAD512 RAD51B2 RAD51D2
1 SIMAP similar gene for RAD51C using alignment to 9 protein entries: RA51C_HUMAN (see all proteins):RAD51B
RAD51C for paralogs About GeneDecksing
|
Genomic Variants
for RAD51C gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for RAD51C (56769934 - 56811703 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for RAD51C
1 CNV: 4042
1 Indel: 25885
Human Gene Mutation Database (HGMD): RAD51C
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD51C |
|
Disorders
/ Diseases
for RAD51C gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
RAD51C for disorders About GeneDecksing
OMIM gene information: 602774
OMIM disorders: 613390 613399
UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502
Defects in RAD51C are the cause of Fanconi anemia complementation group O (FANCO) [MIM:613390]. It is adisorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associatedwith cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development ofmalignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomalinstability (increased chromosome breakage) and defective DNA repair Defects in RAD51C are the cause of familial breast-ovarian cancer type 3 (BROVCA3) [MIM:613399]. It is acondition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features inaffected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateralcancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast canceramong men, increased incidence of tumors of other specific organs, such as the prostate
12  diseases for RAD51C: About MalaCardsfanconi anemia, complementation group 0 mulibrey nanism breast-ovarian cancer fanconi's anemia
bloom syndrome ovarian cancer anemia leukopenia
multiple sclerosis t cell deficiency breast cancer prostatitis
3 diseases from the University of Copenhagen DISEASES database for RAD51C:Fanconi's anemia Ovarian cancer Breast cancer 1 Novoseek disease relationship for RAD51C gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
11034073 (1), 12853621 (1) |
Genetic Association Database (GAD): RAD51C
Human Genome Epidemiology (HuGE) Navigator: RAD51C (14 documents)
Export disorders for RAD51C gene to outside databases
|
Publications
for RAD51C gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for RAD51C gene, integrated from 9 sources (see all 75):
(articles sorted by number of sources associating them with RAD51C) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. (PubMed id 9469824)1, 2, 3, 9 Dosanjh M.K....Schild D. (1998)
- Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. (PubMed id 12966089)1, 2, 9 French C.A....Thacker J. (2003)
- Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (2002)
- Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PubMed id 12427746)1, 2, 9 Lio Y.-C.... Chen D.J. (2003)
- Cellular localization of human Rad51C and regulation of ubiquitin-mediated proteolysis of Rad51. (PubMed id 16215984)1, 2, 9 Bennett B.T. and Knight K.L. (2005)
- RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (2002)
- Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. (PubMed id 21990120)1, 2 Thompson E.R.... Campbell I.G. (2012)
- Mutation of the RAD51C gene in a Fanconi anemia-like disorder. (PubMed id 20400963)1, 2 Vaz F....Mathew C.G. (2010)
- Germline mutations in breast and ovarian cancer pedig rees establish RAD51C as a human cancer susceptibility gene. (PubMed id 20400964)1, 2 Meindl A....Hanenberg H. (2010)
- RAD51C facilitates checkpoint signaling by promoting CHK2 phosphorylation. (PubMed id 19451272)1, 2 Badie S....Tarsounas M. (2009)
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External Searches for RAD51C gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing RAD51C gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing RAD51C gene
(According to HUGE)
About This Section
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Specialized Databases showing RAD51C gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for RAD51C | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for RAD51C | Genetics and Cytogenetics in Oncology and Haematology | | NIEHS-SNPs | http://egp.gs.washington.edu/data/rad51c/ | | RAD51 homolog C (S | http://www.genomed.org/lovd/cm/home.php?select_db=RAD51C |
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| Patent Information for RAD51C gene:
Search GeneIP for patents involving RAD51C
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for RAD51C gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for RAD51C | | OriGene shRNA RFP for RAD51C | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD51C | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD51C | | | OriGene Protein Over-expression Lysate for RAD51C | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for RAD51C | | OriGene 3'-UTR Clone for RAD51C | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD51C | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for RAD51C | | OriGene Custom Protein Services for RAD51C | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat RAD51C | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD51C | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD51C | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD51C | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD51C | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD51C |
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| | | | Search Tocris compounds for RAD51C |
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 | | | RAD51C Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51C |
|  |  |  | | | | ThermoFisher Antibodies for RAD51C |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51C |
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