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RAD51C Gene

protein-coding   GIFtS: 65
GCID: GC17P056769

RAD51 Paralog C

(Previous names: RAD51 (S. cerevisiae) homolog C, RAD51 homolog C (S. cerevisiae))
  See RAD51C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
RAD51 Paralog C1 2     RAD51 (S. Cerevisiae) Homolog C1
R51H32 3     RAD51 Homolog C (S. Cerevisiae)1
RAD51L22 3     DNA Repair Protein RAD51 Homolog 32
RAD51-Like Protein 22 3     Yeast RAD51 Homolog 32
BROVCA32 5     RAD51 Homolog C3
FANCO2 5     

External Ids:    HGNC: 98201   Entrez Gene: 58892   Ensembl: ENSG000001083847   OMIM: 6027745   UniProtKB: O435023   
ORGUL members:         

Export aliases for RAD51C gene to outside databases

Previous GC identifers: GC17P056517 GC17P059251 GC17P057112 GC17P057244 GC17P054124 GC17P052130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD51C Gene:
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and
Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA.
This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction
resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four
localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression
of the four genes during amplification has been observed and suggests a possible role in tumor progression.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jul 2013)

GeneCards Summary for RAD51C Gene:
RAD51C (RAD51 paralog C) is a protein-coding gene. Diseases associated with RAD51C include rad51c-related familial susceptibility to breast-ovarian cancer, and fanconi anemia, complementation group o. GO annotations related to this gene include DNA-dependent ATPase activity and crossover junction endodeoxyribonuclease activity. An important paralog of this gene is DMC1.

UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502
Function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous
recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by
DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2
complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
Participates in branch migration and Holliday junction resolution and thus is important for processing HR
intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating
phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell
cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA
damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the
presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic
stability. Involved in maintaining centrosome number in mitosis

Gene Wiki entry for RAD51C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD51C gene promoter:
         SREBP-1c   Nkx2-5   Tal-1beta   SREBP-1b   E47   SREBP-1a   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51C promoter sequence
   Search Chromatin IP Primers for RAD51C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD51C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q22   Ensembl cytogenetic band:  17q22   HGNC cytogenetic band: 17q25.1

RAD51C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51C gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P056769:  view genomic region     (about GC identifiers)

Start:
56,769,934 bp from pter      End:
56,811,703 bp from pter
Size:
41,770 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 3  
Size: 376 amino acids; 42190 Da
Subunit: Interacts with RAD51B and XRCC3. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2.
Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51B and RAD51.
Interacts with SWSAP1; involved in homologous recombination repair
Secondary accessions: O43503 Q3B783
Alternative splicing: 2 isoforms:  O43502-1   O43502-2   

Explore the universe of human proteins at neXtProt for RAD51C: NX_O43502

Explore proteomics data for RAD51C at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See RAD51C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002867.1  NP_478123.1  

    ENSEMBL proteins: 
     ENSP00000464056   ENSP00000463121   ENSP00000336701   ENSP00000432421   ENSP00000436761  
     ENSP00000431637   ENSP00000433332   ENSP00000391450   ENSP00000463473   ENSP00000407282  
     ENSP00000401741   ENSP00000463658  
    Reactome Protein details: O43502

    RAD51C Human Recombinant Protein Products:

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    Novus Biologicals RAD51C Protein
    Novus Biologicals RAD51C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for RAD51C

     
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD51C
    Cloud-Clone Corp. CLIAs for RAD51C
    Search eBioscience for ELISAs for RAD51C 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FANC: Fanconi anemia, complementation groups

    5 InterPro protein domains:
     IPR020588 RecA_ATP-bd
     IPR016467 DNA_recomb/repair_RecA-like
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase
     IPR013632 DNA_recomb/repair_Rad51_C

    Graphical View of Domain Structure for InterPro Entry O43502

    ProtoNet protein and cluster: O43502

    1 Blocks protein domain: IPB013632 Rad51

    UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502
    Similarity: Belongs to the RecA family. RAD51 subfamily


    Find genes that share domains with RAD51C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RA51C_HUMAN, O43502
    Function: Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous
    recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by
    DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2
    complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.
    Participates in branch migration and Holliday junction resolution and thus is important for processing HR
    intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating
    phosphorylation of the checkpoint kinase CHEK2 and thereby transduction of the damage signal, leading to cell
    cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA
    damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the
    presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic
    stability. Involved in maintaining centrosome number in mitosis
    Induction: Stress-induced increase in the mitochondrial levels is seen

         Genatlas biochemistry entry for RAD51C:
    yeast (S cerevisiae) RAD51 homolog 3,highly expressed in testis,involved in mitosis and meiotic recombination
    events

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0000400contributes to four-way junction DNA binding IDA--
    GO:0003677DNA binding TAS9469824
    GO:0005515protein binding IPI16395335
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with RAD51C           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for RAD51C:
     Increased cell death in HCC-19 

         5 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Rad51c):
     embryogenesis  endocrine/exocrine gland  growth/size/body  mortality/aging  reproductive system 

    Find genes that share phenotypes with RAD51C           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad51ctm1.1Sks for RAD51C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD51C
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD51C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD51C

    miRNA
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    miRTarBase miRNAs that target RAD51C:
    hsa-mir-99a-5p (MIRT048689), hsa-mir-100-5p (MIRT048598), hsa-mir-16-5p (MIRT000897), hsa-mir-26b-5p (MIRT029315), hsa-mir-15a-5p (MIRT000898)

    Block miRNA regulation of human, mouse, rat RAD51C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate RAD51C
    SwitchGear 3'UTR luciferase reporter plasmidRAD51C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD51C

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): RAD51C (NM_002876)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51C

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RA51C_HUMAN, O43502: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion. Note=DNA damage induces an
    increase in nuclear levels. Accumulates in DNA damage induced nuclear foci or RAD51C foci which is formed during
    the S or G2 phase of cell cycle. Accumulation at DNA lesions requires the presence of NBN/NBS1, ATM and RPA
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12966089
    GO:0005654nucleoplasm TAS--
    GO:0005657replication fork IDA--
    GO:0005737cytoplasm IDA16215984
    GO:0005739mitochondrion IDA--

    Find genes that share ontologies with RAD51C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD51C About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    2Hemostasis
    Hemostasis0.43
    3Homologous recombination
    Homologous recombination0.40
    4Meiosis (EMD)
    Meiosis
    5Fanconi anemia pathway (KEGG)
    Fanconi anemia pathway


    Find genes that share SuperPaths with RAD51C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for RAD51C
        Factors involved in megakaryocyte development and platelet production
    Meiotic recombination


    2 Kegg Pathways  (Kegg details for RAD51C):
        Homologous recombination
    Fanconi anemia pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD51C: 
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD51C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD51C (O435021, 2, 3 ENSP000003367014) via UniProtKB, MINT, STRING, and/or I2D (see all 202)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD51Q066091, 2, 3, ENSP000002678684EBI-2267048,EBI-297202 MINT-2736051 MINT-2736074 MINT-2736012 I2D: score=3 STRING: ENSP00000267868
    RAD51DO757713, ENSP000003780904I2D: score=2 STRING: ENSP00000378090
    XRCC3O435423, ENSP000003433924I2D: score=3 STRING: ENSP00000343392
    XRCC2O435433, ENSP000003522714I2D: score=1 STRING: ENSP00000352271
    CACNA2D3Q8IZS83, ENSP000002881974I2D: score=1 STRING: ENSP00000288197
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination IMP--
    GO:0000737DNA catabolic process, endonucleolytic IMP14716019
    GO:0006259DNA metabolic process ----
    GO:0006281DNA repair IDA19451272
    GO:0006310DNA recombination IDA19451272

    Find genes that share ontologies with RAD51C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD51C (RA51C)

    1 Novoseek inferred chemical compound relationship for RAD51C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    camptothecin 43.8 1 12584174 (1)



    Find genes that share compounds with RAD51C           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD51C gene (2 alternative transcripts): 
    NM_002876.3  NM_058216.2  

    Unigene Cluster for RAD51C:

    RAD51 homolog C (S. cerevisiae)
    Hs.412587  [show with all ESTs]
    Unigene Representative Sequence: BC073161
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461271(uc010wob.1) ENST00000583539(uc010woa.1) ENST00000337432(uc002iwu.3 uc002iww.3)
    ENST00000487921 ENST00000476741 ENST00000475762(uc010ddc.3) ENST00000486827(uc002iwt.1)
    ENST00000487525 ENST00000482007 ENST00000421782 ENST00000584617 ENST00000425173
    ENST00000413590 ENST00000581221 ENST00000578151 ENST00000584804 ENST00000461706

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      QuantiFast Probe-based Assays in human, mouse, rat RAD51C

    Additional mRNA sequence: 

    AF029669.1 AF029670.1 AK129738.1 AK290487.1 AK303363.1 BC064578.1 BC073161.1 BC093930.1 
    BC101485.1 BC107753.1 BC143259.1 BT007339.1 

    20 DOTS entries:

    DT.100027246  DT.92434296  DT.95286890  DT.100027245  DT.415025  DT.455920  DT.97844308  DT.70102713 
    DT.95378440  DT.97769874  DT.120971433  DT.97844306  DT.99947554  DT.120971389  DT.75130816  DT.120971382 
    DT.120971465  DT.91683507  DT.95200687  DT.40131687 

    Selected AceView cDNA sequences (see all 181):

    NM_058216 BC000667 BM563459 BE252096 AI350972 BM832934 BC064578 CB990405 
    BE257856 BF593234 BG220326 BP873523 AF029669 AI431899 CR623930 AA909265 
    CA843435 AA748784 BQ431590 AI796161 CA843688 BU752278 BC073161 BQ881780 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD51C (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14
    SP1:                                -                 -           -                 -     -     -           -     -           -                     
    SP2:                                -                 -     -     -                 -     -     -           -     -           -                     
    SP3:                                -                 -     -     -                             -           -     -           -                     
    SP4:                                                                                            -           -     -           -                     
    SP5:                                                                                -     -     -           -     -           -     -               


    ECgene alternative splicing isoforms for RAD51C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD51C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    RAD51C Expression
    About this image


    RAD51C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Testis (Reproductive System)
    RAD51C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD51C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.412587

    UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502
    Tissue specificity: Expressed in a variety of tissues, with highest expression in testis, heart muscle, spleen and
    prostate

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD51C gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad51c1 , 5 RAD51 homolog c (S. cerevisiae)5
    RAD51 homolog C1
    87.67(n)1
    86.85(a)1
      11 (52.08 cM)5
    1147141  NM_053269.31  NP_444499.11 
     873766455 
    chicken
    (Gallus gallus)
    Aves RAD51C1 RAD51 homolog C (S. cerevisiae) 71.51(n)
    73.15(a)
      417626  XM_415870.4  XP_415870.3 
    lizard
    (Anolis carolinensis)
    Reptilia RAD51C6
    RAD51 paralog C
    72(a)
    1 ↔ 1
    AAWZ02040106(21-5874)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.186912 Transcribed sequence with weak similarity to protein more 70.85(n)    AL856750.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.143862 Transcribed sequence with weak similarity to protein more 71.56(n)    BI673100.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta spn-D6
    spindle D
    28(a)
    1 ↔ 1
    3R(22991440-22992844)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DMC16
    Meiosis-specific protein required for repair of do...
    26(a)
    1 → many
    V(548421-549517) YER179W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD51C1 RAD51C 49.9(n)
    40.85(a)
      819136  NM_130091.1  NP_566040.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g05780001 Os01g0578000 49.36(n)
    39(a)
      4323853  NM_001049929.1  NP_001043394.1 


    ENSEMBL Gene Tree for RAD51C (if available)
    TreeFam Gene Tree for RAD51C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD51C gene
    DMC12  RAD51B2  

    Find genes that share paralogs with RAD51C           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD51C (see all 853)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs351514721,2,,4
    C,FBreast-ovarian cancer, familial, 3 (BROVCA3)4 --57789669(+) AGAGGG/AAAGTT 2 /E /G mis12Minor allele frequency- A:0.50NA 4
    rs283633171,2,,4
    C,F,HBreast-ovarian cancer, familial, 3 (BROVCA3)4 --57813662(+) AGATGA/GCAACA 2 T A mis1 ese39Minor allele frequency- G:0.01NS NA EU 6747
    VAR_0640324
    Fanconi anemia complementation group O (FANCO)4--see VAR_0640322 R H mis40--------
    VAR_0638404
    Breast-ovarian cancer, familial, 3 (BROVCA3)4--see VAR_0638402 L F mis40--------
    VAR_0680194
    Breast-ovarian cancer, familial, 3 (BROVCA3)4--see VAR_0680192 Q P mis40--------
    VAR_0638384
    Breast-ovarian cancer, familial, 3 (BROVCA3)4--see VAR_0638382 G V mis40--------
    rs283633021,2
    C,F--56771586(+) TTGTAC/-CTTGT 2 -- int12Minor allele frequency- -:0.21NS CSA 182
    rs99079551,2
    C--56773300(+) gttcaC/Tgccta 1 -- int10--------
    rs287431811,2
    C--56773801(+) AAATAAAATA/
            
    TCCTT
    1 -- int11Minor allele frequency- -:0.01NS 174
    rs107162421,2
    C--56778607(+) CTCAC-/TGCCTG 1 -- int11Minor allele frequency- T:0.00CSA 2

    HapMap Linkage Disequilibrium report for RAD51C (56769934 - 56811703 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for RAD51C (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664231CNV Deletion23128226
    esv1778308CNV Deletion17803354
    esv2716079CNV Deletion23290073
    esv991006CNV Deletion20482838
    esv2674642CNV Deletion23128226
    nsv833498CNV Loss17160897
    nsv908644CNV Loss21882294
    dgv3236n71CNV Loss21882294
    nsv908642CNV Loss21882294
    nsv428347CNV Gain18775914

    Human Gene Mutation Database (HGMD): RAD51C
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD51C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602774   
    OMIM disorders: 613390  613399  
    UniProtKB/Swiss-Prot: RA51C_HUMAN, O43502
  • Fanconi anemia complementation group O (FANCO) [MIM:613390]: A disorder affecting all bone marrow
    elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb
    malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the
    cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased
    chromosome breakage) and defective DNA repair. Note=The disease is caused by mutations affecting the gene
    represented in this entry
  • Breast-ovarian cancer, familial, 3 (BROVCA3) [MIM:613399]: A condition associated with familial
    predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age
    of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in
    both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased
    incidence of tumors of other specific organs, such as the prostate. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for RAD51C:    
    About MalaCards
    rad51c-related familial susceptibility to breast-ovarian cancer    fanconi anemia, complementation group o    breast-ovarian cancer, familial 3    rad51c-related fanconi anemia
    breast-ovarian cancer, familial, 2    mulibrey nanism    fanconi anemia, complementation group c    fanconi's anemia
    ovarian cancer

    3 diseases from the University of Copenhagen DISEASES database for RAD51C:
    Fanconi's anemia     Ovarian cancer     Breast cancer

    Find genes that share disorders with RAD51C           About GenesLikeMe

    1 Novoseek inferred disease relationship for RAD51C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 11034073 (1), 12853621 (1)

    Genetic Association Database (GAD): RAD51C
    Human Genome Epidemiology (HuGE) Navigator: RAD51C (14 documents)

    Export disorders for RAD51C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD51C gene, integrated from 10 sources (see all 88):
    (articles sorted by number of sources associating them with RAD51C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of RAD51C, a new human member of the RAD51 family of related genes. (PubMed id 9469824)1, 2, 3, 9 Dosanjh M.K....Schild D. (Nucleic Acids Res. 1998)
    2. Identification of functional domains in the RAD51L2 (RAD51C) protein and its requirement for gene conversion. (PubMed id 12966089)1, 2, 9 French C.A.... Thacker J. (J. Biol. Chem. 2003)
    3. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (Nucleic Acids Res. 2002)
    4. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PubMed id 12427746)1, 2, 9 Lio Y.-C.... Chen D.J. (J. Biol. Chem. 2003)
    5. Cellular localization of human Rad51C and regulation of ubiquitin- mediated proteolysis of Rad51. (PubMed id 16215984)1, 2, 9 Bennett B.T. and Knight K.L. (J. Cell. Biochem. 2005)
    6. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (J. Biol. Chem. 2002)
    7. Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. (PubMed id 22167183)1, 3 Somyajit K....Nagaraju G. (J. Biol. Chem. 2012)
    8. Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients. (PubMed id 21990120)1, 2 Thompson E.R.... Campbell I.G. (Hum. Mutat. 2012)
    9. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PubMed id 21965664)1, 2 Liu T.... Huang J. (J. Biol. Chem. 2011)
    10. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5889 HGNC: 9820 AceView: RAD51C Ensembl:ENSG00000108384 euGenes: HUgn5889
    ECgene: RAD51C Kegg: 5889 H-InvDB: RAD51C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD51C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD51C Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51c/
    RAD51 homolog C (Shttp://www.genomed.org/lovd/cm/home.php?select_db=RAD51C

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD51C gene:
    Search GeneIP for patents involving RAD51C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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