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RAD51B Gene

protein-coding   GIFtS: 52
GCID: GC14P068287

RAD51 Paralog B

(Previous names: RAD51 (S. cerevisiae)-like 1, RAD51-like 1 (S. cerevisiae),...)
(Previous symbol: RAD51L1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD51 Paralog B1 2     RAD51-Like 1 (S. Cerevisiae)1
RAD51L11 2 3 5     DNA Repair Protein RAD51 Homolog 22
R51H22 3     RecA-Like Protein2
REC22 3     Recombination Repair Protein2
RAD51 Homolog B2 3     Rad51B3
RAD51 (S. Cerevisiae)-Like 11     RAD51-Like Protein 13
RAD51 Homolog B (S. Cerevisiae)1     

External Ids:    HGNC: 98221   Entrez Gene: 58902   Ensembl: ENSG000001821857   OMIM: 6029485   UniProtKB: O153153   

Export aliases for RAD51B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD51B Gene:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily
conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a
stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as
RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis,
which suggested a role of this protein in sensing DNA damage. At least three alternatively spliced transcript
variants encoding distinct isoforms have been observed. Rearrangements between this locus and high mobility group
AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. (provided by RefSeq, Jul 2011)

GeneCards Summary for RAD51B Gene:
RAD51B (RAD51 paralog B) is a protein-coding gene. Diseases associated with RAD51B include bloom syndrome, and leiomyoma. GO annotations related to this gene include DNA-dependent ATPase activity. An important paralog of this gene is DMC1.

UniProtKB/Swiss-Prot: RA51B_HUMAN, O15315
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51
nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The
BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex
DNA

Gene Wiki entry for RAD51B (RAD51L1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for RAD51B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51B promoter sequence
   Search Chromatin IP Primers for RAD51B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD51B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23-q24.2   Ensembl cytogenetic band:  14q24.1   HGNC cytogenetic band: 14q23-q24.2

RAD51B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51B gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P068287:  view genomic region     (about GC identifiers)

Start:
68,286,496 bp from pter      End:
69,196,935 bp from pter
Size:
910,440 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RA51B_HUMAN, O15315 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 2  
Size: 384 amino acids; 42196 Da
Subunit: Interacts with RAD51C. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a
complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51C and RAD51. Interacts
with SWSAP1; involved in homologous recombination repair
Sequence caution: Sequence=CAD62357.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAD66573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: O60914 O75210 Q3Y4F8 Q6FHX8 Q86SY3 Q86SY4 Q86TR0 Q86U92 Q86U93 Q86U94
Q8N6H4 Q9UPL5
Alternative splicing: 5 isoforms:  O15315-3   O15315-1   O15315-2   O15315-4   O15315-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD51B: NX_O15315

Explore proteomics data for RAD51B at MOPED


See RAD51B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_002868.1  NP_598193.2  NP_598194.1  

ENSEMBL proteins: 
 ENSP00000417408   ENSP00000419881   ENSP00000418859   ENSP00000419471   ENSP00000420061  
 ENSP00000417948   ENSP00000452044   ENSP00000451616   ENSP00000375101  
Reactome Protein details: O15315

RAD51B Human Recombinant Protein Products:

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OriGene Protein Over-expression Lysate for RAD51B
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Novus Biologicals RAD51B Proteins
Novus Biologicals RAD51B Lysates
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RAD51B Antibody Products:

EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD51B
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Novus Biologicals RAD51B Antibodies
Search for Antibodies for RAD51B at Abcam
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ThermoFisher Antibodies for RAD51B
LSBio Antibodies in human, mouse, rat for RAD51B

RAD51B Assay Products:

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GenScript Custom Assay Services for RAD51B
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Browse ELISAs at Cloud-Clone Corp.
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro protein domains:
 IPR020588 RecA_ATP-bd
 IPR016467 DNA_recomb/repair_RecA-like
 IPR027417 P-loop_NTPase
 IPR003593 AAA+_ATPase
 IPR013632 DNA_recomb/repair_Rad51_C

Graphical View of Domain Structure for InterPro Entry O15315

ProtoNet protein and cluster: O15315

1 Blocks protein domain: IPB013632 Rad51

UniProtKB/Swiss-Prot: RA51B_HUMAN, O15315
Similarity: Belongs to the RecA family. RAD51 subfamily


RAD51B for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: RA51B_HUMAN, O15315
Function: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising
during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51
nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The
BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex
DNA

     Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0000400contributes to four-way junction DNA binding IDA--
GO:0003677DNA binding TAS9512535
GO:0003678DNA helicase activity ----
GO:0003690double-stranded DNA binding IDA12441335
     
RAD51B for ontologies           About GeneDecksing


Phenotypes:
     4 GenomeRNAi human phenotypes for RAD51B:
 Increased cell death HMECs cel  Increased cell death in breast  Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Rad51b):
 mortality/aging 

RAD51B for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Rad51btm1Kmic for RAD51B

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD51B
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD51B

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD51B
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD51B

miRNA
Products:
    
miRTarBase miRNAs that target RAD51B:
hsa-mir-484 (MIRT041780)

Block miRNA regulation of human, mouse, rat RAD51B using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate RAD51B:
hsa-miR-1468 hsa-miR-488 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-1248
SwitchGear 3'UTR luciferase reporter plasmidRAD51B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for RAD51B
Predesigned siRNA for gene silencing in human, mouse, rat RAD51B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for RAD51B

Clone
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OriGene ORF clones in mouse, rat for RAD51B
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GenScript Custom all cDNA clones Services for RAD51B
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51B

Cell Line
Products:
     
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Browse ESI BIO Cell Lines and PureStem Progenitors for RAD51B 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RA51B_HUMAN, O15315: Nucleus (Probable)

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus TAS9512535
GO:0005654nucleoplasm TAS--
GO:0005657replication fork IDA--
GO:0033063Rad51B-Rad51C-Rad51D-XRCC2 complex IDA11751635

RAD51B for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for RAD51B About                                                                                                See pathways by source

SuperPathContained pathways About
1Hemostasis
Hemostasis0.43
2Homologous recombination
Homologous recombination0.40
3Meiosis (EMD)
Meiosis
4Factors involved in megakaryocyte development and platelet production
Factors involved in megakaryocyte development and platelet production

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 Reactome Pathway for RAD51B
    Factors involved in megakaryocyte development and platelet production


1 Kegg Pathway  (Kegg details for RAD51B):
    Homologous recombination


RAD51B for pathways           About GeneDecksing

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD51B: 
          DNA Damage Signaling Pathway in human mouse rat
          DNA Repair in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for RAD51B

Selected Interacting proteins for RAD51B (O153151, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
InteractantInteraction Details
GeneCardExternal ID(s)
HIST1H4AP628052, 3MINT-19344 I2D: score=2 
HIST1H4BP628052, 3MINT-19344 I2D: score=2 
HIST1H4CP628052, 3MINT-19344 I2D: score=2 
HIST1H4DP628052, 3MINT-19344 I2D: score=2 
HIST1H4EP628052, 3MINT-19344 I2D: score=2 
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Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000724double-strand break repair via homologous recombination IMP--
GO:0006200ATP catabolic process IDA12441335
GO:0006259DNA metabolic process ----
GO:0006260DNA replication ----
GO:0006281DNA repair TAS9512535

RAD51B for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for RAD51B (RA51B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for RAD51B gene (3 alternative transcripts): 
NM_002877.5  NM_133509.3  NM_133510.3  

Unigene Cluster for RAD51B:

RAD51 homolog B (S. cerevisiae)
Hs.172587  [show with all ESTs]
Unigene Representative Sequence: NM_133509
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
ENST00000479335(uc010aqq.3 uc010aqr.3) ENST00000487861 ENST00000471583(uc001xkd.3)
ENST00000487270(uc001xkf.2) ENST00000488612(uc001xkg.2) ENST00000485181
ENST00000553334 ENST00000553734 ENST00000555907 ENST00000553595 ENST00000474051
ENST00000497460 ENST00000492236 ENST00000554244 ENST00000478014 ENST00000460526
ENST00000469165(uc001xke.3) ENST00000468382
Congresses - knowledge worth sharing:
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat RAD51B using miScript Target Protectors
6 qRT-PCR Assays for microRNAs that regulate RAD51B:
hsa-miR-1468 hsa-miR-488 hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-1248
SwitchGear 3'UTR luciferase reporter plasmidRAD51B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for RAD51B
Predesigned siRNA for gene silencing in human, mouse, rat RAD51B
Clone
Products:
     
OriGene clones in human, mouse for RAD51B (see all 21)
OriGene ORF clones in mouse, rat for RAD51B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for RAD51B
DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51B
Primer
Products:
    
OriGene qPCR primer pairs and template standards for RAD51B
OriGene qSTAR qPCR primer pairs in human, mouse for RAD51B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD51B
  QuantiTect SYBR Green Assays in human, mouse, rat RAD51B
  QuantiFast Probe-based Assays in human, mouse, rat RAD51B

Additional mRNA sequence: 

AK130466.1 AK309787.1 AK310686.1 BC030219.1 BX161515.1 BX248061.1 BX248766.1 CR536560.1 
U84138.1 U92074.1 Y15571.1 

12 DOTS entries:

DT.411351  DT.91710114  DT.99955787  DT.91695711  DT.101980930  DT.100014117  DT.100822153  DT.100014118 
DT.100705070  DT.120787962  DT.75159285  DT.92417673 

Selected AceView cDNA sequences (see all 28):

AU280788 BX326166 BX363599 BX350674 AL597484 BI768345 BM923413 BI766692 
BF312867 AW130643 BX355329 BX385057 BI768407 NM_002877 BX161515 BX248061 
NM_133510 U84138 Y15571 NM_133509 CR536560 CD299284 AA383175 U92074 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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RAD51B expression in normal human tissues (normalized intensities)      RAD51B embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGAAAGTGTT
RAD51B Expression
About this image


RAD51B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Cerebral Cortex
 
 Ovary (Reproductive System)    fully expand to see all 2 entries
         Ovarian Mesenchymal Stroma Cells Ovary Interstitium
         Oviduct
 
 Bone (Muscoskeletal System)
         Bone Marrow
 
 Neural Tube (Nervous System)
         Spinal Ventral Columns
 
 Trophoblast (Extraembryonic Tissues)
         Trophoblast Cells Trophoblast
RAD51B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

RAD51B Protein Expression

Genevestigator expression for RAD51B

SOURCE GeneReport for Unigene cluster: Hs.172587

UniProtKB/Swiss-Prot: RA51B_HUMAN, O15315
Tissue specificity: Expressed in a wide range of tissues

    Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD51B: 
          DNA Damage Signaling Pathway in human mouse rat
          DNA Repair in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for RAD51B
OriGene qSTAR qPCR primer pairs in human, mouse for RAD51B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD51B
QuantiTect SYBR Green Assays in human, mouse, rat RAD51B
QuantiFast Probe-based Assays in human, mouse, rat RAD51B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51B gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Rad51b1 , 5 RAD51-like 1 (S. cerevisiae)5
RAD51 homolog B1
86.18(n)1
85.8(a)1
  12 (35.51 cM)5
193631  NM_009014.31  NP_033040.21 
 792973515 
chicken
(Gallus gallus)
Aves RAD51B1 RAD51 homolog B (S. cerevisiae) 72.93(n)
73.7(a)
  769071  XM_004941706.1  XP_004941763.1 
lizard
(Anolis carolinensis)
Reptilia RAD51B6
RAD51 paralog B
61(a)
1 ↔ 1
GL343272.1(448949-814977)
zebrafish
(Danio rerio)
Actinopterygii wufd07f042 Danio rerio cDNA clone MGC56581 IMAGE5914991, complete more 74.04(n)    BC052122.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC16
Meiosis-specific protein required for repair of do...
28(a)
1 → many
V(548421-549517) YER179W
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51B1 RAD51B 45.7(n)
31.16(a)
  817404  NM_001036361.1  NP_001031438.1 
rice
(Oryza sativa)
Liliopsida Os05g01217001 Os05g0121700 44.54(n)
36.01(a)
  4337655  NM_001061035.1  NP_001054500.1 


ENSEMBL Gene Tree for RAD51B (if available)
TreeFam Gene Tree for RAD51B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for RAD51B gene
DMC12  RAD51C2  

RAD51B for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for RAD51B (see all 13958)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1928452821,2
C--48546141(+) GGAGGC/TGGAGC 3 -- int10--------
rs790129481,2
C--48560016(-) TTCTGC/TACAAC 3 -- int10--------
rs351896531,2
C--48563507(+) TTGTA-/TGTGTGT 3 -- int10--------
rs342931611,2
C--48563525(+) GTGTG-/ATGT/ 
 TA
/TGTA
TGTGT
3 -- int10--------
rs108732091,2
C,F,A,H--48569551(+) CTATTT/ATAGGT 3 -- int11Minor allele frequency- A:0.50NA 6
rs108732101,2
C,F,A,H--48569552(+) TATTAT/GAGGTG 3 -- int16Minor allele frequency- G:0.37NS NA WA EA 574
rs1434791821,2
C--48573609(+) AATGG-/TAATAG 3 -- int10--------
rs2016551641,2
--48575850(+) TATAT-/ATA   
  TATATA
TTTTT
3 -- int10--------
rs356569451,2
C--48588025(+) ATAGA-/AAAAAAA 3 -- int10--------
rs1441298771,2
C--48591376(+) TGCCT-/AAATGT 3 -- int10--------

HapMap Linkage Disequilibrium report for RAD51B (68286496 - 68536496 bp, first 250kb of RAD51B)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for RAD51B (see all 42):    About this table    
Variant IDTypeSubtypePubMed ID
esv2315033CNV Deletion18987734
esv2748814CNV Deletion23290073
esv999446CNV Deletion20482838
esv2748813CNV Deletion23290073
esv2748809CNV Deletion23290073
esv2748815CNV Deletion23290073
esv2198876CNV Deletion18987734
esv2663782CNV Deletion23128226
esv1205109CNV Deletion17803354
dgv399e199CNV Deletion23128226

Human Gene Mutation Database (HGMD): RAD51B
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing RAD51B
DNA2.0 Custom Variant and Variant Library Synthesis for RAD51B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602948    OMIM disorders: --

UniProtKB/Swiss-Prot: RA51B_HUMAN, O15315
  • Note=A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation
    t(6;14)(p21;q23-24) with HMGA1
  • Note=A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation
    t(12;14)(q15;q23-24) with HMGA2

  • 19 diseases for RAD51B:    About MalaCards
    bloom syndrome    leiomyoma    primary biliary cirrhosis    age related macular degeneration
    fanconi's anemia    meningioma    nasopharyngitis    retinoblastoma
    multiple sclerosis    breast cancer    tonsillitis    obesity
    prostate cancer    thyroiditis    multiple myeloma    myeloma
    cerebritis    prostatitis    endotheliitis


    RAD51B for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for RAD51B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uterine leiomyoma 64.9 6 16778173 (1), 11135437 (1), 10565301 (1), 9892177 (1) (see all 5)
    benign tumor 32.6 1 16778173 (1)
    chromosomal aberrations 30.2 1 16778173 (1)
    tumors 0 1 16778173 (1)


    Export disorders for RAD51B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD51B gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with RAD51B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. (PubMed id 9207106)1, 2, 3 Rice M.C.... Kmiec E.B. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PubMed id 12427746)1, 2, 9 Lio Y.-C.... Chen D.J. (J. Biol. Chem. 2003)
    3. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PubMed id 11744692)1, 2, 9 Miller K.A....Albala J.S. (J. Biol. Chem. 2002)
    4. Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas. (PubMed id 9892177)1, 2, 9 Schoenmakers E.F.P.M.... Van de Ven W.J.M. (Cancer Res. 1999)
    5. Identification of a novel human RAD51 homolog, RAD51B. (PubMed id 9441753)1, 2, 9 Albala J.S.... Lennon G.G. (Genomics 1997)
    6. Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. (PubMed id 12649198)1, 2, 9 Quade B.J....Morton C.C. (Cancer Res. 2003)
    7. Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells. (PubMed id 11842112)1, 2, 9 Wiese C....Schild D. (Nucleic Acids Res. 2002)
    8. hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. (PubMed id 21965664)1, 2 Liu T.... Huang J. (J. Biol. Chem. 2011)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5890 HGNC: 9822 AceView: RAD51L1 Ensembl:ENSG00000182185 euGenes: HUgn5890
    ECgene: RAD51B Kegg: 5890 H-InvDB: RAD51B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD51B Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51l1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD51B gene:
    Search GeneIP for patents involving RAD51B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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