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Aliases for RAD51B Gene

Aliases for RAD51B Gene

  • RAD51 Paralog B 2 3 5
  • RAD51 Homolog B 3 4
  • RAD51L1 3 4
  • R51H2 3 4
  • REC2 3 4
  • DNA Repair Protein RAD51 Homolog 2 3
  • RAD51 Homolog B (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae)-Like 1 2
  • RAD51-Like 1 (S. Cerevisiae) 2
  • Recombination Repair Protein 3
  • RAD51-Like Protein 1 4
  • RecA-Like Protein 3
  • Rad51B 4

External Ids for RAD51B Gene

Previous HGNC Symbols for RAD51B Gene

  • RAD51L1

Previous GeneCards Identifiers for RAD51B Gene

  • GC14P068287

Summaries for RAD51B Gene

Entrez Gene Summary for RAD51B Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

GeneCards Summary for RAD51B Gene

RAD51B (RAD51 Paralog B) is a Protein Coding gene. Diseases associated with RAD51B include Leiomyoma, Uterine, Somatic and Leiomyoma. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Homologous DNA Pairing and Strand Exchange. GO annotations related to this gene include nucleotide binding and single-stranded DNA binding. An important paralog of this gene is RAD51C.

UniProtKB/Swiss-Prot for RAD51B Gene

  • Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene Wiki entry for RAD51B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51B Gene

Genomics for RAD51B Gene

Regulatory Elements for RAD51B Gene

Enhancers for RAD51B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F067851 1.6 FANTOM5 Ensembl ENCODE 12.5 +33.0 33005 3.2 MTA2 JUNB MAFG YBX1 NR2F2 ZNF316 MAFF PBX2 TARDBP IKZF1 ZFYVE26 RAD51B PIR59795
GH14F067882 0.5 Ensembl ENCODE 12.1 +63.6 63619 1.2 ATF1 MLX ZNF133 ARID4B FEZF1 ZNF48 SP5 REST PPARG KAT8 RAD51B ZFYVE26 PIR59795
GH14F067884 1.1 Ensembl ENCODE 12.1 +64.7 64719 0.6 ZNF133 ZNF18 RAD51B ZFYVE26 PIR59795
GH14F067891 0.4 ENCODE 11.6 +72.8 72799 1.9 HDGF PKNOX1 ZNF687 KLF1 RFX1 L3MBTL2 TAF1 MNT GATA3 ZFHX2 RAD51B ZFYVE26 PIR59795
GH14F068277 1.1 FANTOM5 Ensembl ENCODE 1.6 +462.8 462781 9.5 HDGF PKNOX1 ARNT WRNIP1 DMAP1 YY1 ZNF766 ELK1 ZNF143 ZNF207 PPIAP6 VTI1B RAD51B GC14P068302 RN7SL108P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around RAD51B on UCSC Golden Path with GeneCards custom track

Promoters for RAD51B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098375 321 2201 HDGF ATF1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ETS1 ZNF207 ZNF143

Genomic Location for RAD51B Gene

Chromosome:
14
Start:
67,819,779 bp from pter
End:
68,730,218 bp from pter
Size:
910,440 bases
Orientation:
Plus strand

Genomic View for RAD51B Gene

Genes around RAD51B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD51B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD51B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51B Gene

Proteins for RAD51B Gene

  • Protein details for RAD51B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15315-RA51B_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 2
    Protein Accession:
    O15315
    Secondary Accessions:
    • O60914
    • O75210
    • Q3Y4F8
    • Q6FHX8
    • Q86SY3
    • Q86SY4
    • Q86TR0
    • Q86U92
    • Q86U93
    • Q86U94
    • Q8N6H4
    • Q9UPL5

    Protein attributes for RAD51B Gene

    Size:
    384 amino acids
    Molecular mass:
    42196 Da
    Quaternary structure:
    • Part of the BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2; the complex has a ring-like structure arranged into a flat disc around a central channel. The BCDX2 subcomplex RAD51B:RAD51C interacts with RAD51. Interacts with SWSAP1; involved in homologous recombination repair.
    SequenceCaution:
    • Sequence=CAD62357.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD66573.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for RAD51B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51B Gene

Post-translational modifications for RAD51B Gene

No data available for DME Specific Peptides for RAD51B Gene

Domains & Families for RAD51B Gene

Suggested Antigen Peptide Sequences for RAD51B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15315

UniProtKB/Swiss-Prot:

RA51B_HUMAN :
  • Belongs to the RecA family. RAD51 subfamily.
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with RAD51B: view

No data available for Gene Families for RAD51B Gene

Function for RAD51B Gene

Molecular function for RAD51B Gene

UniProtKB/Swiss-Prot Function:
Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

Gene Ontology (GO) - Molecular Function for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000150 recombinase activity IBA --
GO:0000166 nucleotide binding IEA --
GO:0000400 contributes_to four-way junction DNA binding IDA 20207730
GO:0003677 DNA binding IEA,TAS 9512535
GO:0003690 double-stranded DNA binding IDA 12441335
genes like me logo Genes that share ontologies with RAD51B: view
genes like me logo Genes that share phenotypes with RAD51B: view

Animal Models for RAD51B Gene

MGI Knock Outs for RAD51B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD51B Gene

Localization for RAD51B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51B Gene COMPARTMENTS Subcellular localization image for RAD51B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS 9512535
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IDA 20207730
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RAD51B: view

Pathways & Interactions for RAD51B Gene

genes like me logo Genes that share pathways with RAD51B: view

Gene Ontology (GO) - Biological Process for RAD51B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000707 meiotic DNA recombinase assembly IBA --
GO:0000724 double-strand break repair via homologous recombination IEA,IMP 23149936
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with RAD51B: view

No data available for SIGNOR curated interactions for RAD51B Gene

Drugs & Compounds for RAD51B Gene

(2) Drugs for RAD51B Gene - From: ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 14
Poly(ADP-ribose) Polymerase Inhibitors Pharma 309
genes like me logo Genes that share compounds with RAD51B: view

Transcripts for RAD51B Gene

Unigene Clusters for RAD51B Gene

RAD51 homolog B (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51B Gene

No ASD Table

Relevant External Links for RAD51B Gene

GeneLoc Exon Structure for
RAD51B
ECgene alternative splicing isoforms for
RAD51B

Expression for RAD51B Gene

mRNA expression in normal human tissues for RAD51B Gene

Protein differential expression in normal tissues from HIPED for RAD51B Gene

This gene is overexpressed in CD4 Tcells (33.2) and Placenta (33.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD51B Gene



Protein tissue co-expression partners for RAD51B Gene

NURSA nuclear receptor signaling pathways regulating expression of RAD51B Gene:

RAD51B

SOURCE GeneReport for Unigene cluster for RAD51B Gene:

Hs.172587

mRNA Expression by UniProt/SwissProt for RAD51B Gene:

O15315-RA51B_HUMAN
Tissue specificity: Expressed in a wide range of tissues.
genes like me logo Genes that share expression patterns with RAD51B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAD51B Gene

Orthologs for RAD51B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51L1 34
  • 100 (n)
RAD51B 35
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51B 34 35
  • 92.58 (n)
dog
(Canis familiaris)
Mammalia RAD51B 34 35
  • 90.74 (n)
mouse
(Mus musculus)
Mammalia Rad51b 34 16 35
  • 86.18 (n)
rat
(Rattus norvegicus)
Mammalia Rad51b 34
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD51B 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD51B 34 35
  • 72.93 (n)
lizard
(Anolis carolinensis)
Reptilia RAD51B 35
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rad51b 34 35
  • 59.84 (n)
wufd07f04 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DMC1 35
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51B 34
  • 45.7 (n)
rice
(Oryza sativa)
Liliopsida Os05g0121700 34
  • 44.54 (n)
Species where no ortholog for RAD51B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51B Gene

ENSEMBL:
Gene Tree for RAD51B (if available)
TreeFam:
Gene Tree for RAD51B (if available)

Paralogs for RAD51B Gene

Paralogs for RAD51B Gene

genes like me logo Genes that share paralogs with RAD51B: view

Variants for RAD51B Gene

Sequence variations from dbSNP and Humsavar for RAD51B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs117190791 Likely benign 68,472,157(+) TTAAT(A/G)GTGTG intron-variant, downstream-variant-500B
rs117405447 Likely benign 68,000,183(+) TTTTC(C/T)TAACC intron-variant
rs184721768 Likely benign 68,387,096(+) CCCGT(C/T)TCCTC intron-variant
rs34436700 Likely benign 68,468,143(+) TGACT(A/G/T)ACCCT intron-variant
rs533348490 Likely benign 68,291,792(+) AACCA(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51B Gene

Variant ID Type Subtype PubMed ID
dgv1095n106 CNV deletion 24896259
dgv1096n106 CNV deletion 24896259
dgv131e215 CNV deletion 23714750
dgv36n6 CNV deletion 16902084
dgv399e199 CNV deletion 23128226
dgv59n73 CNV deletion 24416366
dgv649e212 CNV gain 25503493
esv1003046 CNV deletion 20482838
esv1041303 CNV deletion 17803354
esv1205109 CNV deletion 17803354
esv1361357 CNV insertion 17803354
esv2198876 CNV deletion 18987734
esv2315033 CNV deletion 18987734
esv2439284 CNV deletion 19546169
esv2489967 CNV deletion 19546169
esv2658077 CNV deletion 23128226
esv2663782 CNV deletion 23128226
esv2666318 CNV deletion 23128226
esv2748809 CNV deletion 23290073
esv2748810 CNV deletion 23290073
esv2748811 CNV deletion 23290073
esv2748812 CNV deletion 23290073
esv2748813 CNV deletion 23290073
esv2748814 CNV deletion 23290073
esv2748815 CNV deletion 23290073
esv28449 CNV loss 19812545
esv2856791 CNV duplication 24192839
esv3184404 CNV deletion 24192839
esv3244940 CNV deletion 24192839
esv3306715 CNV mobile element insertion 20981092
esv3308025 CNV mobile element insertion 20981092
esv3309729 CNV mobile element insertion 20981092
esv3333574 CNV insertion 20981092
esv3408662 CNV insertion 20981092
esv3551698 CNV deletion 23714750
esv3551699 CNV deletion 23714750
esv3551701 CNV deletion 23714750
esv3567998 CNV gain 25503493
esv3581262 CNV loss 25503493
esv3634810 CNV loss 21293372
esv3634811 CNV loss 21293372
esv3634812 CNV loss 21293372
esv3634814 CNV loss 21293372
esv3634815 CNV loss 21293372
esv3634816 CNV loss 21293372
esv3634817 CNV loss 21293372
esv3634818 CNV loss 21293372
esv3634822 CNV loss 21293372
esv3634823 CNV loss 21293372
esv3634825 CNV loss 21293372
esv3634826 CNV loss 21293372
esv9245 CNV loss 19470904
esv999446 CNV deletion 20482838
nsv1048064 CNV loss 25217958
nsv1048794 CNV loss 25217958
nsv1054697 CNV gain 25217958
nsv1071153 CNV deletion 25765185
nsv1071154 CNV deletion 25765185
nsv1115465 CNV duplication 24896259
nsv1116460 OTHER inversion 24896259
nsv1124996 CNV deletion 24896259
nsv1127387 CNV deletion 24896259
nsv1134384 CNV deletion 24896259
nsv1138311 CNV deletion 24896259
nsv1147670 CNV deletion 26484159
nsv1149828 CNV deletion 26484159
nsv1324 CNV insertion 18451855
nsv1325 CNV insertion 18451855
nsv1326 CNV insertion 18451855
nsv1327 CNV insertion 18451855
nsv1328 CNV insertion 18451855
nsv473363 CNV novel sequence insertion 20440878
nsv474832 CNV novel sequence insertion 20440878
nsv510383 OTHER sequence alteration 20534489
nsv512364 CNV loss 21212237
nsv516239 CNV gain 19592680
nsv518669 CNV gain 19592680
nsv521761 CNV gain 19592680
nsv525928 CNV loss 19592680
nsv564962 CNV loss 21841781
nsv832822 CNV loss 17160897
nsv85056 CNV deletion 16902084
nsv85157 CNV deletion 16902084
nsv85374 CNV deletion 16902084
nsv85709 CNV insertion 16902084
nsv952858 CNV deletion 24416366
nsv976350 CNV duplication 23825009
nsv977482 CNV duplication 23825009
nsv977483 CNV duplication 23825009

Variation tolerance for RAD51B Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD51B Gene

Human Gene Mutation Database (HGMD)
RAD51B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD51B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51B Gene

Disorders for RAD51B Gene

MalaCards: The human disease database

(5) MalaCards diseases for RAD51B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leiomyoma, uterine, somatic
  • uterine fibroid
leiomyoma
  • leiomyomatous neoplasm
uterine benign neoplasm
reproductive organ benign neoplasm
macular degeneration, age-related, 1
  • macular degeneration, age-related, 2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RA51B_HUMAN
  • Note=A chromosomal aberration involving RAD51B is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with HMGA1. {ECO:0000269 PubMed:11978964}.
  • Note=A chromosomal aberration involving RAD51B is found in uterine leiomyoma. Translocation t(12;14)(q15;q23-24) with HMGA2. {ECO:0000269 PubMed:12649198, ECO:0000269 PubMed:9892177}.

Relevant External Links for RAD51B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD51B
genes like me logo Genes that share disorders with RAD51B: view

No data available for Genatlas for RAD51B Gene

Publications for RAD51B Gene

  1. Domain mapping of the Rad51 paralog protein complexes. (PMID: 14704354) Miller K.A. … Albala J.S. (Nucleic Acids Res. 2004) 3 4 22 64
  2. Holliday junction binding activity of the human Rad51B protein. (PMID: 12441335) Yokoyama H. … Shibata T. (J. Biol. Chem. 2003) 3 4 22 64
  3. Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro. (PMID: 12427746) Lio Y.-C. … Chen D.J. (J. Biol. Chem. 2003) 3 4 22 64
  4. Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15. (PMID: 12649198) Quade B.J. … Morton C.C. (Cancer Res. 2003) 3 4 22 64
  5. RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51. (PMID: 11744692) Miller K.A. … Albala J.S. (J. Biol. Chem. 2002) 3 4 22 64

Products for RAD51B Gene

Sources for RAD51B Gene

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