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Aliases for RAD51AP1 Gene

Aliases for RAD51AP1 Gene

  • RAD51 Associated Protein 1 2 3 5
  • RAD51-Interacting Protein 3 4
  • PIR51 3 4
  • RAD51-Associated Protein 1 3

External Ids for RAD51AP1 Gene

Previous GeneCards Identifiers for RAD51AP1 Gene

  • GC12P004519
  • GC12P004647
  • GC12P004651
  • GC12P004694

Summaries for RAD51AP1 Gene

GeneCards Summary for RAD51AP1 Gene

RAD51AP1 (RAD51 Associated Protein 1) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-Loop Structures. GO annotations related to this gene include RNA binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for RAD51AP1 Gene

  • May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51AP1 Gene

Genomics for RAD51AP1 Gene

Regulatory Elements for RAD51AP1 Gene

Enhancers for RAD51AP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around RAD51AP1 on UCSC Golden Path with GeneCards custom track

Promoters for RAD51AP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RAD51AP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for RAD51AP1 Gene

Chromosome:
12
Start:
4,538,746 bp from pter
End:
4,560,048 bp from pter
Size:
21,303 bases
Orientation:
Plus strand

Genomic View for RAD51AP1 Gene

Genes around RAD51AP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD51AP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD51AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51AP1 Gene

Proteins for RAD51AP1 Gene

  • Protein details for RAD51AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B01-R51A1_HUMAN
    Recommended name:
    RAD51-associated protein 1
    Protein Accession:
    Q96B01
    Secondary Accessions:
    • A8K7D3
    • O43403
    • Q7Z779

    Protein attributes for RAD51AP1 Gene

    Size:
    352 amino acids
    Molecular mass:
    38457 Da
    Quaternary structure:
    • Isoform 2 interacts with RAD51. Interacts with PALB2. Interacts (via C-terminal region) with RAD51; the interaction is direct.

    Alternative splice isoforms for RAD51AP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51AP1 Gene

Post-translational modifications for RAD51AP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD51AP1 Gene

Domains & Families for RAD51AP1 Gene

Protein Domains for RAD51AP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAD51AP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAD51AP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RAD51AP1 Gene

Function for RAD51AP1 Gene

Molecular function for RAD51AP1 Gene

UniProtKB/Swiss-Prot Function:
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

Gene Ontology (GO) - Molecular Function for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IDA 9396801
GO:0003697 single-stranded DNA binding IDA 9396801
GO:0003723 RNA binding IDA 9396801
GO:0005515 protein binding IPI 9396801
genes like me logo Genes that share ontologies with RAD51AP1: view
genes like me logo Genes that share phenotypes with RAD51AP1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAD51AP1

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAD51AP1 Gene

Localization for RAD51AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Nucleus. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51AP1 Gene COMPARTMENTS Subcellular localization image for RAD51AP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 26323318
GO:0005634 nucleus IC,IDA 26323318
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RAD51AP1: view

Pathways & Interactions for RAD51AP1 Gene

genes like me logo Genes that share pathways with RAD51AP1: view

Gene Ontology (GO) - Biological Process for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination NAS 9396801
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0006281 DNA repair NAS 9396801
GO:0010569 regulation of double-strand break repair via homologous recombination IDA 23754376
genes like me logo Genes that share ontologies with RAD51AP1: view

No data available for SIGNOR curated interactions for RAD51AP1 Gene

Drugs & Compounds for RAD51AP1 Gene

No Compound Related Data Available

Transcripts for RAD51AP1 Gene

Unigene Clusters for RAD51AP1 Gene

RAD51 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51AP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RAD51AP1 Gene

GeneLoc Exon Structure for
RAD51AP1
ECgene alternative splicing isoforms for
RAD51AP1

Expression for RAD51AP1 Gene

mRNA expression in normal human tissues for RAD51AP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAD51AP1 Gene

This gene is overexpressed in Bone (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD51AP1 Gene



Protein tissue co-expression partners for RAD51AP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAD51AP1 Gene:

RAD51AP1

SOURCE GeneReport for Unigene cluster for RAD51AP1 Gene:

Hs.730696

mRNA Expression by UniProt/SwissProt for RAD51AP1 Gene:

Q96B01-R51A1_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with RAD51AP1: view

Primer Products

No data available for mRNA differential expression in normal tissues for RAD51AP1 Gene

Orthologs for RAD51AP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAD51AP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAD51AP1 34
  • 79.63 (n)
  • 69.14 (a)
RAD51AP1 35
  • 70 (a)
OneToMany
RAD51AP1 35
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAD51AP1 34
  • 85.42 (n)
  • 77.84 (a)
RAD51AP1 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad51ap1 34
  • 72.31 (n)
  • 61.63 (a)
Rad51ap1 16
Rad51ap1 35
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAD51AP1 34
  • 99.62 (n)
  • 98.86 (a)
RAD51AP1 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51ap1 34
  • 71.59 (n)
  • 59.64 (a)
oppossum
(Monodelphis domestica)
Mammalia RAD51AP1 35
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51AP1 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD51AP1 34
  • 58.01 (n)
  • 43.42 (a)
RAD51AP1 35
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51ap1 34
  • 55.08 (n)
  • 43.61 (a)
Str.6355 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24463 34
zebrafish
(Danio rerio)
Actinopterygii rad51ap1 34
  • 46.32 (n)
  • 38.55 (a)
rad51ap1 35
  • 33 (a)
OneToOne
Species where no ortholog for RAD51AP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51AP1 Gene

ENSEMBL:
Gene Tree for RAD51AP1 (if available)
TreeFam:
Gene Tree for RAD51AP1 (if available)

Paralogs for RAD51AP1 Gene

Pseudogenes.org Pseudogenes for RAD51AP1 Gene

genes like me logo Genes that share paralogs with RAD51AP1: view

No data available for Paralogs for RAD51AP1 Gene

Variants for RAD51AP1 Gene

Sequence variations from dbSNP and Humsavar for RAD51AP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs34810644 - 4,543,897(-) TTTTT(G/T)AGGGG reference, missense
rs7308641 -- 4,558,744(+) TAGAC(A/C)CTGGA intron-variant
rs7314915 -- 4,548,037(+) CCTAT(A/T)TCTAG intron-variant
rs7315154 -- 4,548,212(+) CATCA(A/G)CAATG intron-variant
rs7955370 -- 4,549,396(+) tCATA(A/C)ATTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51AP1 Gene

Variant ID Type Subtype PubMed ID
nsv1040098 CNV gain 25217958
nsv483060 CNV loss 15286789
nsv557123 CNV gain 21841781
nsv832318 CNV gain 17160897

Variation tolerance for RAD51AP1 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD51AP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD51AP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Disorders for RAD51AP1 Gene

Relevant External Links for RAD51AP1

Genetic Association Database (GAD)
RAD51AP1
Human Genome Epidemiology (HuGE) Navigator
RAD51AP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD51AP1

No disorders were found for RAD51AP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD51AP1 Gene

Publications for RAD51AP1 Gene

  1. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. (PMID: 9396801) Kovalenko O.V. … Radding C.M. (Nucleic Acids Res. 1997) 2 3 4 65
  2. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J. … Chen J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4 65
  3. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 46 65
  4. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. (PMID: 20871616) Dray E. … Sung P. (Nat. Struct. Mol. Biol. 2010) 3 4 65
  5. Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. (PMID: 17996711) Wiese C. … Schild D. (Mol. Cell 2007) 3 22 65

Products for RAD51AP1 Gene

Sources for RAD51AP1 Gene

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