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Aliases for RAD51AP1 Gene

Aliases for RAD51AP1 Gene

  • RAD51 Associated Protein 1 2 3
  • PIR51 3 4 6
  • RAD51-Interacting Protein 3 4
  • RAD51-Associated Protein 1 3

External Ids for RAD51AP1 Gene

Summaries for RAD51AP1 Gene

GeneCards Summary for RAD51AP1 Gene

RAD51AP1 (RAD51 Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include RNA binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for RAD51AP1 Gene

  • May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51AP1 Gene

Genomics for RAD51AP1 Gene

Genomic Location for RAD51AP1 Gene

Start:
4,538,774 bp from pter
End:
4,560,048 bp from pter
Size:
21,275 bases
Orientation:
Plus strand

Genomic View for RAD51AP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51AP1 Gene

Regulatory Elements for RAD51AP1 Gene

Proteins for RAD51AP1 Gene

  • Protein details for RAD51AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B01-R51A1_HUMAN
    Recommended name:
    RAD51-associated protein 1
    Protein Accession:
    Q96B01
    Secondary Accessions:
    • A8K7D3
    • O43403
    • Q7Z779

    Protein attributes for RAD51AP1 Gene

    Size:
    352 amino acids
    Molecular mass:
    38457 Da
    Quaternary structure:
    • Isoform 2 interacts with RAD51. Interacts with PALB2. Interacts (via C-terminal region) with RAD51; the interaction is direct.

    Alternative splice isoforms for RAD51AP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51AP1 Gene

Proteomics data for RAD51AP1 Gene at MOPED

Post-translational modifications for RAD51AP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD51AP1 Gene

Domains for RAD51AP1 Gene

Protein Domains for RAD51AP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAD51AP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAD51AP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for RAD51AP1 Gene

Function for RAD51AP1 Gene

Molecular function for RAD51AP1 Gene

UniProtKB/Swiss-Prot Function: May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

Gene Ontology (GO) - Molecular Function for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003690 double-stranded DNA binding IDA 9396801
GO:0003697 single-stranded DNA binding IDA 9396801
GO:0003723 RNA binding IDA 9396801
GO:0005515 protein binding IPI 20871616
genes like me logo Genes that share ontologies with RAD51AP1: view

Phenotypes for RAD51AP1 Gene

GenomeRNAi human phenotypes for RAD51AP1:
genes like me logo Genes that share phenotypes with RAD51AP1: view

miRNA for RAD51AP1 Gene

miRTarBase miRNAs that target RAD51AP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RAD51AP1 Gene

Localization for RAD51AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Nucleus. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51AP1 Gene COMPARTMENTS Subcellular localization image for RAD51AP1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IC 9396801
genes like me logo Genes that share ontologies with RAD51AP1: view

Pathways for RAD51AP1 Gene

SuperPathways for RAD51AP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination NAS 9396801
GO:0006281 DNA repair NAS 9396801
GO:0006310 DNA recombination --
GO:0010569 regulation of double-strand break repair via homologous recombination IDA 23754376
GO:0071479 cellular response to ionizing radiation IDA 23754376
genes like me logo Genes that share ontologies with RAD51AP1: view

No data available for Pathways by source for RAD51AP1 Gene

Transcripts for RAD51AP1 Gene

Unigene Clusters for RAD51AP1 Gene

RAD51 associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51AP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RAD51AP1 Gene

GeneLoc Exon Structure for
RAD51AP1
ECgene alternative splicing isoforms for
RAD51AP1

Expression for RAD51AP1 Gene

mRNA expression in normal human tissues for RAD51AP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51AP1 Gene

SOURCE GeneReport for Unigene cluster for RAD51AP1 Gene Hs.730696

mRNA Expression by UniProt/SwissProt for RAD51AP1 Gene

Q96B01-R51A1_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes.
genes like me logo Genes that share expressions with RAD51AP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for RAD51AP1 Gene

Orthologs for RAD51AP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAD51AP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51AP1 35
  • 99.62 (n)
  • 98.86 (a)
RAD51AP1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51AP1 35
  • 79.63 (n)
  • 69.14 (a)
RAD51AP1 36
  • 70 (a)
OneToMany
RAD51AP1 36
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RAD51AP1 35
  • 85.42 (n)
  • 77.84 (a)
RAD51AP1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad51ap1 35
  • 72.31 (n)
  • 61.63 (a)
Rad51ap1 16
Rad51ap1 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD51AP1 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51AP1 36
  • 39 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51ap1 35
  • 71.59 (n)
  • 59.64 (a)
chicken
(Gallus gallus)
Aves RAD51AP1 35
  • 58.01 (n)
  • 43.42 (a)
RAD51AP1 36
  • 43 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24463 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51ap1 35
  • 55.08 (n)
  • 43.61 (a)
Str.6355 35
zebrafish
(Danio rerio)
Actinopterygii rad51ap1 35
  • 46.32 (n)
  • 38.55 (a)
rad51ap1 36
  • 33 (a)
OneToOne
Species with no ortholog for RAD51AP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51AP1 Gene

ENSEMBL:
Gene Tree for RAD51AP1 (if available)
TreeFam:
Gene Tree for RAD51AP1 (if available)

Paralogs for RAD51AP1 Gene

Pseudogenes.org Pseudogenes for RAD51AP1 Gene

genes like me logo Genes that share paralogs with RAD51AP1: view

No data available for Paralogs for RAD51AP1 Gene

Variants for RAD51AP1 Gene

Sequence variations from dbSNP and Humsavar for RAD51AP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1046147 -- 4,559,824(+) TTTCA(G/T)GAAGC utr-variant-3-prime
rs2907492 -- 4,546,504(-) TACCT(C/G)TTTCC intron-variant
rs2907493 -- 4,545,773(-) CAATT(A/G)AAGGA intron-variant
rs2970804 -- 4,542,521(-) TTAAG(A/G)CTGTG intron-variant
rs7136384 -- 4,555,753(+) TCACC(G/T)CCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51AP1 Gene

Variant ID Type Subtype PubMed ID
nsv832318 CNV Gain 17160897

Relevant External Links for RAD51AP1 Gene

HapMap Linkage Disequilibrium report
RAD51AP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Disorders for RAD51AP1 Gene

Relevant External Links for RAD51AP1

Genetic Association Database (GAD)
RAD51AP1
Human Genome Epidemiology (HuGE) Navigator
RAD51AP1
genes like me logo Genes that share disorders with RAD51AP1: view

No data available for UniProtKB/Swiss-Prot for RAD51AP1 Gene

Publications for RAD51AP1 Gene

  1. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. (PMID: 9396801) Kovalenko O.V. … Radding C.M. (Nucleic Acids Res. 1997) 2 3 4
  2. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G. … White R.L. (Alcohol. Clin. Exp. Res. 2010) 3 48
  3. Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. (PMID: 14966907) Song H. … Zhao M.J. (World J. Gastroenterol. 2004) 3 23
  4. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. (PMID: 16990250) Kovalenko O.V. … Schild D. (Nucleic Acids Res. 2006) 4 23
  5. Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement. (PMID: 17996711) Wiese C. … Schild D. (Mol. Cell 2007) 3 23

Products for RAD51AP1 Gene

Sources for RAD51AP1 Gene

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