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Aliases for RAD51AP1 Gene

Aliases for RAD51AP1 Gene

  • RAD51 Associated Protein 1 2 3 5
  • RAD51-Interacting Protein 3 4
  • PIR51 3 4
  • RAD51-Associated Protein 1 3

External Ids for RAD51AP1 Gene

Previous GeneCards Identifiers for RAD51AP1 Gene

  • GC12P004519
  • GC12P004647
  • GC12P004651
  • GC12P004694
  • GC12P004858
  • GC12P005014
  • GC12P005177

Summaries for RAD51AP1 Gene

GeneCards Summary for RAD51AP1 Gene

RAD51AP1 (RAD51 Associated Protein 1) is a Protein Coding gene. Among its related pathways are DNA Double-Strand Break Repair and Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA). GO annotations related to this gene include RNA binding and single-stranded DNA binding.

UniProtKB/Swiss-Prot for RAD51AP1 Gene

  • May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

Additional gene information for RAD51AP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51AP1 Gene

Genomics for RAD51AP1 Gene

Regulatory Elements for RAD51AP1 Gene

Enhancers for RAD51AP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H004439 1.1 Ensembl ENCODE 10.1 -97.5 -97492 2.9 ZBTB21 KLF17 FEZF1 ZIC2 ZNF324 ZFHX2 ZBTB48 PATZ1 EGR2 MAZ C12orf4 FGF23 RAD51AP1 FGF6
GH12H004564 0.9 Ensembl ENCODE 11.8 +27.9 27947 4.2 ZNF687 NR2F1 BHLHE40 ELF1 DPF2 IKZF1 HMBOX1 NBN IKZF2 SPI1 AKAP3 C12orf4 RAD51AP1 LOC103568124 NDUFA9 TIGAR DYRK4
GH12H004561 0.9 ENCODE 10.6 +23.4 23442 1.2 ARID4B KLF17 GLIS2 SP5 MXD4 REST KAT8 ZNF592 TFDP1 RFX3 C12orf4 RAD51AP1 AKAP3 DYRK4 GC12M004550
GH12H004414 0.9 Ensembl ENCODE 10.1 -123.6 -123587 0.9 L3MBTL2 NRF1 BHLHE40 MNT GATA3 POLR2A IKZF1 FOXP2 RCOR1 FGF6 FGF23 C12orf4 RAD51AP1
GH12H004506 0.8 ENCODE 10.8 -31.5 -31530 1.8 ELF3 SOX13 FOXA2 TBL1XR1 SAP130 MLX BATF ZNF644 YY1 EED FGF6 FGF23 RAD51AP1 C12orf4 TIGAR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAD51AP1 on UCSC Golden Path with GeneCards custom track

Promoters for RAD51AP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048094 -146 2001 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Locations for RAD51AP1 Gene

Genomic Locations for RAD51AP1 Gene
chr12:4,538,746-4,560,048
(GRCh38/hg38)
Size:
21,303 bases
Orientation:
Plus strand
chr12:4,647,950-4,669,214
(GRCh37/hg19)

Genomic View for RAD51AP1 Gene

Genes around RAD51AP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD51AP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD51AP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51AP1 Gene

Proteins for RAD51AP1 Gene

  • Protein details for RAD51AP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B01-R51A1_HUMAN
    Recommended name:
    RAD51-associated protein 1
    Protein Accession:
    Q96B01
    Secondary Accessions:
    • A8K7D3
    • O43403
    • Q7Z779

    Protein attributes for RAD51AP1 Gene

    Size:
    352 amino acids
    Molecular mass:
    38457 Da
    Quaternary structure:
    • Isoform 2 interacts with RAD51. Interacts with PALB2. Interacts (via C-terminal region) with RAD51; the interaction is direct.

    Alternative splice isoforms for RAD51AP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51AP1 Gene

Post-translational modifications for RAD51AP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD51AP1 Gene

Domains & Families for RAD51AP1 Gene

Gene Families for RAD51AP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAD51AP1 Gene

Suggested Antigen Peptide Sequences for RAD51AP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RAD51AP1: view

No data available for UniProtKB/Swiss-Prot for RAD51AP1 Gene

Function for RAD51AP1 Gene

Molecular function for RAD51AP1 Gene

UniProtKB/Swiss-Prot Function:
May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA.

Phenotypes From GWAS Catalog for RAD51AP1 Gene

Gene Ontology (GO) - Molecular Function for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003690 double-stranded DNA binding IEA,IDA 9396801
GO:0003697 single-stranded DNA binding IDA,IEA 9396801
GO:0003723 RNA binding IEA,IDA 9396801
GO:0005515 protein binding IPI 9396801
genes like me logo Genes that share ontologies with RAD51AP1: view
genes like me logo Genes that share phenotypes with RAD51AP1: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAD51AP1 Gene

Localization for RAD51AP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Nucleus. Note=Colocalizes with RAD51 to multiple nuclear foci. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD51AP1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 26323318
GO:0005634 nucleus IEA,IDA 26323318
GO:0005654 nucleoplasm TAS --
GO:0043234 protein complex IMP 16990250
genes like me logo Genes that share ontologies with RAD51AP1: view

Pathways & Interactions for RAD51AP1 Gene

genes like me logo Genes that share pathways with RAD51AP1: view

Gene Ontology (GO) - Biological Process for RAD51AP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination NAS 9396801
GO:0000731 DNA synthesis involved in DNA repair TAS --
GO:0000732 strand displacement TAS --
GO:0006281 DNA repair IEA,NAS 9396801
GO:0006310 DNA recombination IEA --
genes like me logo Genes that share ontologies with RAD51AP1: view

No data available for SIGNOR curated interactions for RAD51AP1 Gene

Drugs & Compounds for RAD51AP1 Gene

No Compound Related Data Available

Transcripts for RAD51AP1 Gene

Unigene Clusters for RAD51AP1 Gene

RAD51 associated protein 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51AP1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: -
SP2: - -
SP3: - - -
SP4: -
SP5:

Relevant External Links for RAD51AP1 Gene

GeneLoc Exon Structure for
RAD51AP1
ECgene alternative splicing isoforms for
RAD51AP1

Expression for RAD51AP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD51AP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAD51AP1 Gene

This gene is overexpressed in Bone (68.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD51AP1 Gene



Protein tissue co-expression partners for RAD51AP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAD51AP1 Gene:

RAD51AP1

SOURCE GeneReport for Unigene cluster for RAD51AP1 Gene:

Hs.730696

mRNA Expression by UniProt/SwissProt for RAD51AP1 Gene:

Q96B01-R51A1_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Lower levels in colon and small intestine. Little or no expression in spleen, prostate, ovary and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with RAD51AP1: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD51AP1 Gene

Orthologs for RAD51AP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAD51AP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51AP1 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia RAD51AP1 33 34
  • 85.42 (n)
cow
(Bos Taurus)
Mammalia RAD51AP1 33 34 34
  • 79.63 (n)
mouse
(Mus musculus)
Mammalia Rad51ap1 33 16 34
  • 72.31 (n)
rat
(Rattus norvegicus)
Mammalia Rad51ap1 33
  • 71.59 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD51AP1 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51AP1 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD51AP1 33 34
  • 58.01 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51ap1 33
  • 55.08 (n)
Str.6355 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24463 33
zebrafish
(Danio rerio)
Actinopterygii rad51ap1 33 34
  • 46.32 (n)
Species where no ortholog for RAD51AP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD51AP1 Gene

ENSEMBL:
Gene Tree for RAD51AP1 (if available)
TreeFam:
Gene Tree for RAD51AP1 (if available)

Paralogs for RAD51AP1 Gene

Pseudogenes.org Pseudogenes for RAD51AP1 Gene

genes like me logo Genes that share paralogs with RAD51AP1: view

No data available for Paralogs for RAD51AP1 Gene

Variants for RAD51AP1 Gene

Sequence variations from dbSNP and Humsavar for RAD51AP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000039036 -- 4,557,503(+) AAAAC(G/T)TTTTG intron-variant
rs1000163898 -- 4,542,534(+) GTATC(C/T)ACCAC intron-variant
rs1000233434 -- 4,544,566(+) ACCTC(A/G)TGTCA intron-variant
rs1000386806 -- 4,538,048(+) GGAAT(A/G)TTGAA intron-variant, upstream-variant-2KB
rs1000644794 -- 4,560,408(+) CTATT(A/C)ATTAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for RAD51AP1 Gene

Variant ID Type Subtype PubMed ID
nsv832318 CNV gain 17160897
nsv557123 CNV gain 21841781
nsv483060 CNV loss 15286789
nsv1040098 CNV gain 25217958

Variation tolerance for RAD51AP1 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.07; 60.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD51AP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD51AP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51AP1 Gene

Disorders for RAD51AP1 Gene

Relevant External Links for RAD51AP1

Genetic Association Database (GAD)
RAD51AP1
Human Genome Epidemiology (HuGE) Navigator
RAD51AP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD51AP1

No disorders were found for RAD51AP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD51AP1 Gene

Publications for RAD51AP1 Gene

  1. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. (PMID: 16990250) Kovalenko OV … Schild D (Nucleic acids research 2006) 3 4 22 60
  2. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. (PMID: 9396801) Kovalenko OV … Radding CM (Nucleic acids research 1997) 2 3 4 60
  3. FIGNL1-containing protein complex is required for efficient homologous recombination repair. (PMID: 23754376) Yuan J … Chen J (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4 60
  4. Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 45 60
  5. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. (PMID: 20871616) Dray E … Sung P (Nature structural & molecular biology 2010) 3 4 60

Products for RAD51AP1 Gene

Sources for RAD51AP1 Gene

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