Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAD51 Gene

Aliases for RAD51 Gene

  • RAD51 Recombinase 2 3
  • RAD51A 3 4 6
  • RECA 3 4 6
  • RAD51 Homolog A 3 4
  • HsRad51 3 4
  • HRAD51 3 4
  • MRMV2 3 6
  • RAD51 Homolog (RecA Homolog, E. Coli) (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae) Homolog (E Coli RecA Homolog) 2
  • BRCA1/BRCA2-Containing Complex, Subunit 5 3
  • DNA Repair Protein RAD51 Homolog 1 3
  • BRCA1/BRCA2-Containing Complex 2
  • RAD51 Homolog (S. Cerevisiae) 2
  • RecA, E. Coli, Homolog Of 3
  • Recombination Protein A 3
  • RecA-Like Protein 3
  • Subunit 5 2
  • HsT16930 3
  • BRCC5 3

External Ids for RAD51 Gene

Previous Symbols for RAD51 Gene

  • RAD51A
  • RECA

Summaries for RAD51 Gene

Entrez Gene Summary for RAD51 Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for RAD51 Gene

RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include mirror movements 2 and familial congenital mirror movements. Among its related pathways are Pathways in cancer and ERK Signaling. GO annotations related to this gene include identical protein binding and double-stranded DNA binding.

UniProtKB/Swiss-Prot for RAD51 Gene

  • Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Gene Wiki entry for RAD51 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51 Gene

Genomics for RAD51 Gene

Genomic Location for RAD51 Gene

Start:
40,694,774 bp from pter
End:
40,732,339 bp from pter
Size:
37,566 bases
Orientation:
Plus strand

Genomic View for RAD51 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51 Gene

Regulatory Elements for RAD51 Gene

Proteins for RAD51 Gene

  • Protein details for RAD51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06609-RAD51_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 1
    Protein Accession:
    Q06609
    Secondary Accessions:
    • B0FXP0
    • B2R8T6
    • Q6FHX9
    • Q6ZNA8
    • Q9BV60

    Protein attributes for RAD51 Gene

    Size:
    339 amino acids
    Molecular mass:
    36966 Da
    Quaternary structure:
    • Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963).

    Three dimensional structures from OCA and Proteopedia for RAD51 Gene

    Alternative splice isoforms for RAD51 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51 Gene

Proteomics data for RAD51 Gene at MOPED

Post-translational modifications for RAD51 Gene

  • Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58, Lys64, and Lys156

No data available for DME Specific Peptides for RAD51 Gene

Domains for RAD51 Gene

UniProtKB/Swiss-Prot:

RAD51_HUMAN
Domain:
  • The nuclear localization may reside in the C-terminus (between 259 and 339 AA):
    • Q06609
  • Contains 1 HhH domain.:
    • Q06609
Family:
  • Belongs to the RecA family. RAD51 subfamily.:
    • Q06609
genes like me logo Genes that share domains with RAD51: view

No data available for Gene Families for RAD51 Gene

Function for RAD51 Gene

Molecular function for RAD51 Gene

GENATLAS Biochemistry: yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor prognosis,uncommonly associated with parathyroid tumorigenesis
UniProtKB/Swiss-Prot Function: Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.
UniProtKB/Swiss-Prot Induction: Stress-induced increase in the mitochondrial levels is seen.

Gene Ontology (GO) - Molecular Function for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding IEA --
GO:0003690 double-stranded DNA binding IDA 7988572
GO:0003697 single-stranded DNA binding IDA 7988572
genes like me logo Genes that share ontologies with RAD51: view
genes like me logo Genes that share phenotypes with RAD51: view

Animal Models for RAD51 Gene

MGI Knock Outs for RAD51:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAD51 Gene

Localization for RAD51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD51 Gene COMPARTMENTS Subcellular localization image for RAD51 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 23754376
GO:0000793 condensed chromosome ISS --
GO:0000794 condensed nuclear chromosome ISS --
GO:0000800 lateral element IEA --
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with RAD51: view

Pathways for RAD51 Gene

genes like me logo Genes that share pathways with RAD51: view

Gene Ontology (GO) - Biological Process for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination TAS 12427746
GO:0000730 DNA recombinase assembly TAS --
GO:0006200 obsolete ATP catabolic process --
GO:0006259 DNA metabolic process --
GO:0006268 DNA unwinding involved in DNA replication IDA 7988572
genes like me logo Genes that share ontologies with RAD51: view

Compounds for RAD51 Gene

(1) Drugbank Compounds for RAD51 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphoaminophosphonic Acid-Adenylate Ester
target

(62) Novoseek inferred chemical compound relationships for RAD51 Gene

Compound -log(P) Hits PubMed IDs
atpgammas 83 42
adenosine 5-o-(3-thiotriphosphate) 79.9 15
5-formyl-2-deoxyuridine 74.4 5
atp 67.7 149
mitomycin c 62.4 12
genes like me logo Genes that share compounds with RAD51: view

Transcripts for RAD51 Gene

Unigene Clusters for RAD51 Gene

RAD51 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for RAD51 Gene

GeneLoc Exon Structure for
RAD51
ECgene alternative splicing isoforms for
RAD51

Expression for RAD51 Gene

mRNA expression in normal human tissues for RAD51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD51 Gene

This gene is overexpressed in Testis (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD51 Gene

SOURCE GeneReport for Unigene cluster for RAD51 Gene Hs.631709

mRNA Expression by UniProt/SwissProt for RAD51 Gene

Q06609-RAD51_HUMAN
Tissue specificity: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast
genes like me logo Genes that share expressions with RAD51: view

Orthologs for RAD51 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51 36
  • 99.8 (n)
  • 100 (a)
RAD51 37
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51 36
  • 93.22 (n)
  • 99.41 (a)
RAD51 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD51 36
  • 94.2 (n)
  • 99.12 (a)
RAD51 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad51 36
  • 91.05 (n)
  • 98.82 (a)
Rad51 16
Rad51 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD51 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51 36
  • 91.45 (n)
  • 99.41 (a)
chicken
(Gallus gallus)
Aves RAD51 36
  • 81.51 (n)
  • 95.58 (a)
RAD51A 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD51 37
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia rad51-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51 36
  • 79.27 (n)
  • 96.73 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3942 36
zebrafish
(Danio rerio)
Actinopterygii rad51 36
  • 77.31 (n)
  • 91.04 (a)
rad51 37
  • 81 (a)
OneToOne
wufb38e12 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013412 36
  • 67.27 (n)
  • 81.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta spn-A 36
  • 65.11 (n)
  • 68.63 (a)
spn-A 37
  • 61 (a)
OneToOne
Rad51 38
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea rad-51 36
  • 58.19 (n)
  • 59.17 (a)
rad-51 37
  • 47 (a)
OneToOne
rad-51 38
  • 59 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR226W 36
  • 63.71 (n)
  • 71.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD51 36
  • 60.2 (n)
  • 67.76 (a)
RAD51 37
  • 51 (a)
OneToOne
RAD51 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20241g 36
  • 64.56 (n)
  • 69.94 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51 36
  • 66.05 (n)
  • 71.3 (a)
corn
(Zea mays)
Liliopsida Zm.631 36
rice
(Oryza sativa)
Liliopsida Os.19630 36
Os12g0497300 36
  • 66.46 (n)
  • 70.82 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7197 36
bread mold
(Neurospora crassa)
Ascomycetes NCU02741 36
  • 65.29 (n)
  • 75.87 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp51 36
  • 66.27 (n)
  • 75.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7666 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3685 37
  • 66 (a)
OneToOne
Species with no ortholog for RAD51:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAD51 Gene

ENSEMBL:
Gene Tree for RAD51 (if available)
TreeFam:
Gene Tree for RAD51 (if available)

Paralogs for RAD51 Gene

genes like me logo Genes that share paralogs with RAD51: view

No data available for Paralogs for RAD51 Gene

Variants for RAD51 Gene

Sequence variations from dbSNP and Humsavar for RAD51 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs957603 -- 40,717,470(-) AATGA(C/T)GCTAA intron-variant
rs1056742 -- 40,731,095(+) TCTGC(A/C)AAATC reference, missense
rs1804269 -- 40,729,538(+) ACCGC(C/T)CTTTA reference, synonymous-codon
rs2229876 -- 40,729,635(+) ATGAG(A/T)TTGGT splice-donor-variant
rs2304579 -- 40,698,955(+) ACCCA(A/G/T)ATTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51 Gene

Variant ID Type Subtype PubMed ID
nsv832984 CNV Loss 17160897
dgv739e1 CNV Complex 17122850
nsv904099 CNV Loss 21882294
nsv529030 CNV Loss 19592680
nsv904100 CNV Loss 21882294
nsv904101 CNV Loss 21882294
nsv527234 CNV Loss 19592680
esv2478123 CNV Deletion 19546169

Relevant External Links for RAD51 Gene

HapMap Linkage Disequilibrium report
RAD51
Human Gene Mutation Database (HGMD)
RAD51

Disorders for RAD51 Gene

(2) OMIM Diseases for RAD51 Gene (179617)

UniProtKB/Swiss-Prot

RAD51_HUMAN
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:10807537}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:22305526}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(4) University of Copenhagen DISEASES for RAD51 Gene

(26) Novoseek inferred disease relationships for RAD51 Gene

Disease -log(P) Hits PubMed IDs
fanconis anemia 66.7 2
bloom syndrome 64.4 4
ataxia telangiectasia 50.6 2
breast cancer 50.3 80
germ-line mutation 47.4 2

Relevant External Links for RAD51

Genetic Association Database (GAD)
RAD51
Human Genome Epidemiology (HuGE) Navigator
RAD51
genes like me logo Genes that share disorders with RAD51: view

Publications for RAD51 Gene

  1. A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PMID: 11535547) Wang W.W. … Struewing J.P. (Cancer Epidemiol. Biomarkers Prev. 2001) 3 4 23 49
  2. A single nucleotide polymorphism in the RAD51 gene modifies cancer risk in BRCA2 but not BRCA1 carriers. (PMID: 11248061) Levy-Lahad E. … Gershoni-Baruch R. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 23 49
  3. Identification of Rad51 alteration in patients with bilateral breast cancer. (PMID: 10807537) Kato M. … Miki Y. (J. Hum. Genet. 2000) 3 4 23
  4. A novel human Rad54 homologue, Rad54B, associates with Rad51. (PMID: 10851248) Tanaka K. … Miyagawa K. (J. Biol. Chem. 2000) 3 4 23
  5. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. (PMID: 7988572) Benson F.E. … West S.C. (EMBO J. 1994) 3 4 23

Products for RAD51 Gene

Sources for RAD51 Gene

Back to Top

Content