V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

RAD51 Gene

protein-coding GIFtS: 72

GC15P038774

RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)
(Previous name: RAD51 (S. cerevisiae) homolog (E coli RecA homolog) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: RAD51A, RECA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BRCC5 ^¹, ²
HRAD51 ^²
HsRAD51 ^³
HsRad51 ^¹, ²
HsT16930 ^¹, ²
RAD51A ^², ³
RAD51D ^⁵
RAD51L3 ^⁵
RECA ^², ³
hRAD51 ^³

Descriptions
BRCA1/BRCA2-containing complex, subunit 5 ^²
DNA repair protein RAD51 homolog 1 ^²
RAD51 (S. cerevisiae) homolog (E coli RecA homolog) ^¹
RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) ^²
RAD51 homolog protein ^²
RecA, E. coli, homolog of ^²
RecA-like protein ^²
recombination protein A ^²

External Ids
HGNC: 9817¹
Entrez Gene: 5888²
UniProtKB: Q06609³
Ensembl: ENSG00000051180⁷

Search outside databases for aliases for RAD51 gene

Previous GC identifers: GC15P036354 GC15P033883 GC15P038566 GC15P038703

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for RAD51:

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are

highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved

in the homologous recombination and repair of DNA. This protein can interact with the

ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and

strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be

important for the cellular response to DNA damage. BRCA2 is shown to regulate both the

intracellular localization and DNA-binding ability of this protein. Loss of these controls

following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis.

Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have

been reported. Transcript variants utilizing alternative polyA signals exist. [provided by RefSeq]

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609

Function: May participate in a common DNA damage response pathway associated with the activation of

homologous recombination and double-strand break repair. Binds to single and double stranded DNA

and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein

filaments

Gene Wiki entry for RAD51

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the RAD51 gene

Entrez Gene cytogenetic band: 15q15.1 Ensembl cytogenetic band: 15q15.1 HGNC cytogenetic band: 15q15.1

RAD51 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P038774: (about GC identifiers)

Start:	38,774,651 bp from pter
End:	38,811,648 bp from pter
Size:	36,998 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000015.8 NT_010194.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609 (See protein sequence)

Recommended Name: DNA repair protein RAD51 homolog 1

Size: 339 amino acids; 36966 Da

Subunit: Interacts with BRCA1, BRCA2 and either directly or indirectly with p53. Interacts with

XRCC3, RAD54L and RAD54B. Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and

RAD51AP2. Interacts with CHEK1/CHK1, and this may require prior phosphorylation of CHEK1.

Interacts with the MND1-PSMC3IP heterodimer (By similarity). Interacts with OBFC2B

Subcellular location: Nucleus. Note=Colocalizes with RAD51AP1 to multiple nuclear foci upon

induction of DNA damage

PDB structure from and Proteopedia :

1B22 (3D)

1N0W (3D)

Secondary accessions: Q6FHX9 Q9BV60

Alternative splicing: 2 isoforms: Q06609-1 Q06609-2

Post-translational modifications:

Phosphorylated. Phosphorylation of Thr-309 by CHEK1/CHK1 may enhance association with chromatin at

sites of DNA damage and promote DNA repair by homologous recombination¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_002866.2 NP_597994.2

ENSEMBL proteins:

ENSP00000372088 ENSP00000267868 ENSP00000372087

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Rad51)
	Human Recombinant Proteins from Abnova (RAD51)

OriGene Purified Recombinant Human Protein: RAD51

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000794	condensed nuclear chromosome	ISS	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	ISS	--
GO:0005654	nucleoplasm	EXP	9826763 10438626 11080452 12606939
GO:0016605	PML body	IDA	11309417

About this table

Antibodies for RAD51:

	Invitrogen Antibodies for RAD51
	Millipore Mono- and Polyclonal Antibodies for the study of RAD51
	Sigma-Aldrich Antibodies for RAD51
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Rad51), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (RAD51)
	Novus Biologicals Antibodies for RAD51

Assays for RAD51:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q06609

ProtoNet protein and cluster: Q06609

2 Blocks protein families:

IPB003583 Helix-hairpin-helix DNA-binding

IPB013632 Rad51

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609

Similarity: Belongs to the recA family. RAD51 subfamily

Similarity: Contains 1 HhH domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAD51)
		Millipore RNAi Products for the Analysis of RAD51 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RAD51)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002875

Applied Biosystems Silencer® siRNAs for RAD51

Sigma-Aldrich siRNA and siRNA Panels for RAD51

Sigma-Aldrich shRNA Panels and shRNA for RAD51

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for RAD51
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002875
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002875
untagged cDNA clones in CMV expression vector (see all 2): NM_002875

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002875

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609

Function: May participate in a common DNA damage response pathway associated with the activation of

homologous recombination and double-strand break repair. Binds to single and double stranded DNA

and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein

filaments

Genatlas biochemistry entry for RAD51:

yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding

protein,complexing with phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand

breaks through homologous recombination,also involved in immunoglobulin switch recombination,not

mutated ,deleted in breast cancer with poor prognosis,uncommonly associated with parathyroid

tumorigenesis

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Rad51):

cellular

embryogenesis

growth/size

lethality-prenatal/perinatal

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000150	recombinase activity	ISS	--
GO:0000166	nucleotide binding	IEA	--
GO:0003684	damaged DNA binding	IEA	--
GO:0003690	double-stranded DNA binding	ISS	--
GO:0003697	single-stranded DNA binding	ISS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for RAD51 (Your Favorite Gene powered by Ingenuity)

ATM Signaling
Role of BRCA1 in DNA Damage Response
Purine Metabolism

GeneDecks RAD51 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for RAD51

5/109 Interacting proteins for RAD51 (ENSP00000372088³ Q06609^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 109 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TP53	P04637¹	STRING (score=.997) EBI-297202, EBI-366083
RAD51C	O43502²	STRING (score=.913) MINT-2736051 MINT-2736074 MINT-2736012
ABL1	P00519²	STRING (score=.989) MINT-7034009
DMC1	Q14565²	STRING (score=.776) MINT-4980408
RAD52	P43351²	STRING (score=.999) MINT-6550637

About this table

5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	TAS	12427746
GO:0006268	DNA unwinding during replication	IDA	7988572
GO:0006281	DNA repair	TAS	8358431
GO:0006312	mitotic recombination	TAS	8358431
GO:0006974	response to DNA damage stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for RAD51
10/33 Novoseek chemical compound relationships for RAD51 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atpgammas	82.97	47	9201926 (3), 9718317 (3), 1507222 (2), 2082728 (2) (see all 29)
5-formyl-2'-deoxyuridine	75.44	6	12836321 (2), 11562961 (1), 12903258 (1), 14611842 (1)
atp	67.28	204	11342134 (6), 9012806 (4), 9201926 (4), 15719060 (4) (see all 84)
adp	49.48	43	12758082 (4), 11839740 (3), 15123651 (3), 16624636 (2) (see all 21)
inosine triphosphate	48.26	8	1606138 (3), 1606139 (2)
rpa 2	45.95	1	15326288 (1)
oligonucleotide	42.82	21	9268650 (2), 1962209 (1), 9838005 (1), 9880493 (1) (see all 17)
sugar phosphate	31.34	2	16358736 (1), 17317338 (1)
amp-pnp	23.99	1	9718317 (1)
polynucleotide	22.39	3	1507222 (1), 8420955 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (RAD51)
		Millipore RNAi Products for the Analysis of RAD51 Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (RAD51)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002875

Sigma-Aldrich siRNA and siRNA Panels for RAD51

Sigma-Aldrich shRNA Panels and shRNA for RAD51

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002875 NM_133487

REFSEQ mRNAs for RAD51 gene (2 alternative transcripts):

NM_002875.3 NM_133487.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002875 NM_133487

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002875
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002875
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_002875

Additional cDNA sequence:

AK131299.1 AK291969.1 AK303089.1 AK313503.1 AY425955.1 AY608888.1 BC001459.2 BT019705.1

CR536559.1 CR594665.1 CR606487.1 CR619182.1 CR622784.1 CR626167.1 D13804.1 D14134.1

EU362635.1

10 DOTS entries:

DT.209091 DT.95254199 DT.121050424 DT.95254169 DT.92452043 DT.95085123 DT.91749880 DT.100777886

DT.121050426 DT.95254167

24/118 AceView cDNA sequences (see all 118 ):

BU164989 BM810067 CR622784 CR626167 BM808716 BQ424388 BX494877 AU107551

AY608888 BU624430 BM791694 BG474115 AW363521 CR606487 CR536559 CR619182

AI347079 BC001459 CR594665 BE280848 AU100170 BM910438 BI826961 BE256767

highest scoring ESTs for RAD51:

D14134 AA568782 AA873056 AI347079 AK131299 AL526587 AL526641 AL563755 AW006523 AW103435

Unigene Cluster for RAD51:

RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)

Hs.631709 [show with all ESTs]

Unigene Representative Sequence: NM_002875

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b
SP1:							-		-										-
SP2:									-						-		-
SP3:									-						-		-		-
SP4:									-
SP5:

About this scheme

ECgene alternative splicing isoforms for RAD51

3 Ensembl transcripts including schematic representations:

ENST00000382643 ENST00000267868 ENST00000382642

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

RAD51 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for RAD51

¹ / ² / ³

5 probe-sets matching RAD51 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1872_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D14134	1.00	1.00	1.00	1
205024_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002875	0.60	1.00	0.82	1
205023_at²^{, 3}	U133-A	2	1.00	0.95	--	--	D14134	1.00	1.00	1.00	1
205024_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205023_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCCTTAGG

SOURCE GeneReport for Unigene cluster: Hs.631709
Expression variation in blood from EXPOLDB for RAD51
UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
Tissue specificity: Highly expressed in testis and thymus, followed by small intestine, placenta,
colon, pancreas and ovary. Weakly expressed in breast

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for RAD51 gene from 5/23 species (see all 23 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	RAD51¹	--	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	94.2(n) 99.12(a)	403568 NM_001003043.1 NP_001003043.1
chimpanzee (Pan troglodytes)	RAD51¹	--	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	99.8(n) 100(a)	453339 XM_510313.2 XP_510313.1
cow (Bos taurus)	RAD51¹	--	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	93.22(n) 99.41(a)	514749 NM_001046179.1 NP_001039644.1
rat (Rattus norvegicus)	Rad51¹	--	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	91.45(n) 99.41(a)	499870 XM_575211.2 XP_575211.1
mouse (Mus musculus)	Rad51^{1, 5}	2 (66.80 cM)⁵	RAD51 homolog (S. cerevisiae)^{1, 5}	91.05(n)¹ 98.82(a)¹	19361¹ NM_011234.3¹ NP_035364.1¹ AI451234⁵ AK011242⁵ (see all 19)

About this table Species with no ortholog for RAD51

ENSEMBL Gene Tree for RAD51

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for RAD51 gene

DMC1² XRCC3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/296 NCBI SNPs in RAD51 are shown (see all 296 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs11855560^1,2	A,C,F,H	38811595(+)	`GAGGGC/TAAGTA`	2	--	ut3¹ ese³		8	EU EA WA NA NS	730
	rs12593359^1,2	A,C,F,H	38811170(+)	`TAAGGG/TTTTGG`	2	--	ut3¹		8	EU EA WA NA NS	728
	rs11852786^1,2	A,C,F,H	38811800(+)	`TAAAAC/GCTAAT`	2	--	ng3¹		13	EU EA WA NA NS	1216
	rs7180135^1,2	A,C,F,H	38811386(+)	`ccaagA/Gtggtg`	2	--	ut3¹		5	EU EA WA NS	596
--	rs45549040^1,2	F	38811581(+)	`CAAGAA/CACATT`	2	--	ut3¹		1	NS	176
--	rs45450497^1,2	F	38811819(+)	`AAAAGA/GAAGAC`	2	--	ng3¹		1	NS	174
	rs7174493^1,2	H	38785766(+)	`AAGAGC/GTTGAC`	2	L/V	mis¹ int¹		4	EU EA WA	412
--	rs11544205^1,2	H	38809068(+)	`TTTCAG/TCCAGG`	2	A/S	mis¹ ese³		4	EU EA WA	402
	rs1056742^1,2	H	38810585(+)	`TCTGCA/CAAATC`	2	K/Q	mis¹		5	MN EU EA WA	588
--	rs45507396^1,2	F	38811597(+)	`GGGCAA/GGTAAA`	2	--	ut3¹		1	NS	176

About this table

HapMap Linkage Disequilibrium images for RAD51 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602954

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609

Defects in RAD51 are associated with breast cancer (BC) [MIM:114480]

10/26 Novoseek disease relationships for RAD51 gene (see all 26 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
bloom syndrome	63.95	3	12975363 (1), 10767546 (1), 15143192 (1)
fanconis anemia	61.81	7	12239151 (1), 12483114 (1)
ataxia telangiectasia	50.43	2	15135073 (1), 9315668 (1)
breast cancer	49.52	88	16762046 (7), 18974064 (6), 12673366 (5), 17707537 (3) (see all 38)
germ-line mutation	45.60	1	10463575 (1)
ovarian cancer	34.62	10	11535547 (3), 16005565 (2), 10197592 (1), 16165098 (1) (see all 5)
cancer	32.45	30	19106292 (4), 15150571 (2), 18618591 (2), 9765620 (1) (see all 19)
bilateral breast cancer	28.37	2	17666788 (1), 10807537 (1)
chromosomal aberrations	24.49	2	11283264 (1), 16511829 (1)
tumors	20.44	55	16596227 (5), 11782381 (5), 16234517 (4), 18243065 (3) (see all 27)

About this table

Human Gene Mutation Database: RAD51
Genetic Association Database: RAD51
Human Genome Epidemiology Navigator: RAD51 (62 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/588 PubMed articles for RAD51 gene (see all 588 ):

A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PubMed id 11535547)^{1, 3, 4, 6} Wang W.W.... Struewing J.P. (2001)
Cloning and sequence of the human RecA-like gene cDNA. (PubMed id 8479919)^{2, 3, 4} Yoshimura Y....Matsushiro A. (1993)
Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. (PubMed id 8358431)^{2, 3, 4} Shinohara A.... Ogawa T. (1993)
A novel human rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)^{1, 3, 4} Tanaka K....Miyagawa K. (2000)
Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. (PubMed id 7988572)^{1, 3, 4} Benson F.E.... West S.C. (1994)
RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. (PubMed id 9192668)^{1, 3, 4} Mizuta R.... Alt F.W. (1997)
The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR. (PubMed id 10390347)^{1, 3, 4} Aihara H.... Shibata T. (1999)
Polymorphisms of the BRCA2 and RAD51 genes in breast cancer. (PubMed id 16261408)^{1, 3, 6} Sliwinski T....Blasiak J. (2005)
Polymorphisms of DNA repair genes and risk of glioma. (PubMed id 15313891)^{1, 3, 6} Wang L.E....Wei Q. (2004)
Polymorphisms in genes involved in homologous recombination repair interact to increase the risk of developing acute myeloid leukemia. (PubMed id 15102670)^{1, 3, 6} Seedhouse C....Russell N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5888	HGNC: 9817	AceView: RAD51	Ensembl:ENSG00000051180	euGenes: HUgn5888
ECgene: RAD51	H-InvDB: RAD51

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for RAD51	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/rad51/

Licensable Technologies for RAD51
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for RAD51:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for RAD51-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for RAD51		Antibodies for RAD51
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for RAD51		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (RAD51)
	Antibodies (RAD51)
	Chimera RNAi (RAD51)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Rad51)
	Antibodies (Rad51)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for RAD51

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for RAD51

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
RAD51 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

RAD51 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for RAD51

Summaries
for RAD51

Genomic Location
for RAD51

Proteins
for RAD51

Protein Domains/
Families
for RAD51

Gene Function
for RAD51

Pathways & Interactions
for RAD51

Drugs & Compounds
for RAD51

Transcripts
for RAD51

Expression
for RAD51

Orthologs
for RAD51

Paralogs
for RAD51

SNPs/Variants
for RAD51

Disorders & Mutations
for RAD51

Medical News
for RAD51

Publications
for RAD51

Search for RAD51

Genome Databases showing RAD51

Other Databases showing RAD51

Specialized Databases showing RAD51

Licensable Technologies
for RAD51

Services
for RAD51

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

RAD51 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor RAD51

Summariesfor RAD51

Genomic Locationfor RAD51

Proteinsfor RAD51

Protein Domains/Familiesfor RAD51

Gene Functionfor RAD51

Pathways & Interactionsfor RAD51

Drugs & Compoundsfor RAD51

Transcriptsfor RAD51

Expression for RAD51

Orthologsfor RAD51

Paralogsfor RAD51

SNPs/Variantsfor RAD51

Disorders & Mutationsfor RAD51

Medical Newsfor RAD51

Publicationsfor RAD51

Search for RAD51

Genome Databases showing RAD51

Other Databases showing RAD51

Specialized Databases showing RAD51

Licensable Technologiesfor RAD51

Servicesfor RAD51

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for RAD51

Summaries
for RAD51

Genomic Location
for RAD51

Proteins
for RAD51

Protein Domains/
Families
for RAD51

Gene Function
for RAD51

Pathways & Interactions
for RAD51

Drugs & Compounds
for RAD51

Transcripts
for RAD51

Expression
for RAD51

Orthologs
for RAD51

Paralogs
for RAD51

SNPs/Variants
for RAD51

Disorders & Mutations
for RAD51

Medical News
for RAD51

Publications
for RAD51

Licensable Technologies
for RAD51

Services
for RAD51