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RAD51 Gene

protein-coding   GIFtS: 73
GCID: GC15P040987

RAD51 Recombinase

(Previous names: RAD51 (S. cerevisiae) homolog (E coli RecA homolog), RAD51...)
(Previous symbols: RAD51A, RECA)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD51 Recombinase1 2     HRAD512
RAD51A1 2 3 5     HsRad512
RECA1 2 3 5     HsT169302
RAD51 Homolog A2 3     BRCA1/BRCA2-Containing Complex, Subunit 52
MRMV22 5     DNA Repair Protein RAD51 Homolog 12
BRCA1/BRCA2-Containing Complex1     RecA, E. Coli, Homolog Of2
RAD51 (S. Cerevisiae) Homolog (E Coli RecA Homolog)1     RecA-Like Protein2
RAD51 Homolog (RecA Homolog, E. Coli) (S. Cerevisiae)1     Recombination Protein A2
RAD51 Homolog (S. Cerevisiae)1     HsRAD513
Subunit 51     hRAD513
BRCC52     

External Ids:    HGNC: 98171   Entrez Gene: 58882   Ensembl: ENSG000000511807   OMIM: 1796175   UniProtKB: Q066093   

Export aliases for RAD51 gene to outside databases

Previous GC identifers: GC15P036354 GC15P033883 GC15P038566 GC15P038703 GC15P038774 GC15P017834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD51 Gene:
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar
to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous
recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it
is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact
with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate
both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following
BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Aug 2009)

GeneCards Summary for RAD51 Gene:
RAD51 (RAD51 recombinase) is a protein-coding gene. Diseases associated with RAD51 include breast cancer susceptibility, and mirror movements 1. GO annotations related to this gene include double-stranded DNA binding and identical protein binding.

UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
Function: Participates in a common DNA damage response pathway associated with the activation of homologous
recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent
ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating
mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3

Gene Wiki entry for RAD51 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD51 gene promoter:
         TBP   Elk-1   C/EBPbeta   p53   Meis-1a   TGIF   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD51 promoter sequence
   Search Chromatin IP Primers for RAD51

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD51


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15.1   Ensembl cytogenetic band:  15q15.1   HGNC cytogenetic band: 15q15.1

RAD51 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD51 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P040987:  view genomic region     (about GC identifiers)

Start:
40,986,972 bp from pter      End:
41,024,356 bp from pter
Size:
37,385 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609 (See protein sequence)
Recommended Name: DNA repair protein RAD51 homolog 1  
Size: 339 amino acids; 36966 Da
Subunit: Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B.
Part of a complex with RAD51C and RAD51B. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this
may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer (By similarity). Found in
a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with
SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminus
one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminus region); the interaction is
direct. Interacts with NABP2. Interacts with RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower
level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient
recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination
repair. Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for
strand-pairing reactions during DNA recombination. Interacts with PARPBP, BRCA2 and RECQL5; these interactions
interfere with the formation of the RAD51-DNA homologous recombination structure
2 PDB 3D structures from and Proteopedia for RAD51:
1B22 (3D)        1N0W (3D)    
Secondary accessions: B0FXP0 B2R8T6 Q6FHX9 Q6ZNA8 Q9BV60
Alternative splicing: 4 isoforms:  Q06609-1   Q06609-2   Q06609-3   Q06609-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD51: NX_Q06609

Explore proteomics data for RAD51 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage
    and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function1
  • Ubiquitination2 at Lys58, Lys64, Lys156
  • Modification sites at PhosphoSitePlus

  • See RAD51 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001157741.1  NP_001157742.1  NP_002866.2  NP_597994.3  

    ENSEMBL proteins: 
     ENSP00000432759   ENSP00000406602   ENSP00000267868   ENSP00000454176   ENSP00000433924  
     ENSP00000372088   ENSP00000431864   ENSP00000431897   ENSP00000436512   ENSP00000433053  
    Reactome Protein details: Q06609

    RAD51 Human Recombinant Protein Products:

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    Novus Biologicals RAD51 Protein
    Novus Biologicals RAD51 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD51

    RAD51 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD51
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    RAD51 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for RAD51
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD51
    Cloud-Clone Corp. CLIAs for RAD51


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 9):
     IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
     IPR020587 RecA_monomer-monomer_interface
     IPR020588 RecA_ATP-bd
     IPR010995 DNA_repair_Rad51/TF_NusA_a-hlx
     IPR016467 DNA_recomb/repair_RecA-like

    Graphical View of Domain Structure for InterPro Entry Q06609

    ProtoNet protein and cluster: Q06609

    2 Blocks protein domains:
    IPB003583 Helix-hairpin-helix DNA-binding
    IPB013632 Rad51


    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
    Domain: The nuclear localization may reside in the C-terminus (between 259 and 339 AA)
    Similarity: Belongs to the RecA family. RAD51 subfamily
    Similarity: Contains 1 HhH domain


    RAD51 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD51_HUMAN, Q06609
    Function: Participates in a common DNA damage response pathway associated with the activation of homologous
    recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent
    ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Plays a role in regulating
    mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3
    Induction: Stress-induced increase in the mitochondrial levels is seen

         Genatlas biochemistry entry for RAD51:
    yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with
    phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also
    involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor
    prognosis,uncommonly associated with parathyroid tumorigenesis

         Gene Ontology (GO): Selected molecular function terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003677DNA binding ----
    GO:0003684damaged DNA binding IEA--
    GO:0003690double-stranded DNA binding IDA7988572
    GO:0003697single-stranded DNA binding IDA7988572
         
    RAD51 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for RAD51:
     Decreased homologous recombina  Decreased viability  Decreased viability of wild-ty  Decreased viability with cispl 
     Increased cell death HMECs cel  Synthetic lethal with cisplati 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Rad51):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    RAD51 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for RAD51: Rad51tm1Hst Rad51tm1Tkm

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD51
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD51

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD51
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD51

    miRNA
    Products:
        
    miRTarBase miRNAs that target RAD51:
    hsa-mir-92a-1-5p (MIRT038926), hsa-mir-23b-3p (MIRT046358), hsa-mir-215-5p (MIRT024626), hsa-mir-193b-3p (MIRT016582), hsa-mir-197-3p (MIRT003819), hsa-mir-103a-3p (MIRT027144), hsa-mir-124-3p (MIRT023031), hsa-mir-192-5p (MIRT026888)

    Block miRNA regulation of human, mouse, rat RAD51 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD51 (see all 12):
    hsa-miR-3164 hsa-miR-548d-3p hsa-miR-631 hsa-miR-134 hsa-miR-3661 hsa-miR-888* hsa-miR-221* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAD51 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD51
    Predesigned siRNA for gene silencing in human, mouse, rat RAD51

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAD51

    Clone
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    OriGene clones in human, mouse for RAD51 (see all 26)
    OriGene ORF clones in mouse, rat for RAD51
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RAD51 (NM_002875)
    Sino Biological Human cDNA Clone for RAD51
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD51 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RAD51_HUMAN, Q06609: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Note=Colocalizes
    with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in
    nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing
    radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome IDA--
    GO:0000793condensed chromosome ISS--
    GO:0000794condensed nuclear chromosome ISS--
    GO:0000800lateral element IEA--
    GO:0005634nucleus ISS--

    RAD51 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD51 About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40
    2Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Presynaptic phase of homologous DNA pairing and strand exchange0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    Assembly of the RAD51-ssDNA nucleoprotein complex0.00
    Homologous DNA pairing and strand exchange0.00
    3Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74
    4BRCA1 Pathway
    BRCA1 Pathway
    Fanconi's Anaemia Pathway0.00
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAD51
        ATM Pathway
    Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    Molecular Mechanisms of Cancer

    1 Cell Signaling Technology (CST) Pathway for RAD51
        Cell Cycle / Checkpoint Control

    1 GeneGo (Thomson Reuters) Pathway for RAD51
        DNA damage Role of Brca1 and Brca2 in DNA repair

    5 BioSystems Pathways for RAD51
        DNA damage response
    Homologous recombination
    Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    BARD1 signaling events


    3 Reactome Pathways for RAD51
        Presynaptic phase of homologous DNA pairing and strand exchange
    Meiotic recombination
    Assembly of the RAD51-ssDNA nucleoprotein complex


    4 Kegg Pathways  (Kegg details for RAD51):
        Homologous recombination
    Fanconi anemia pathway
    Pathways in cancer
    Pancreatic cancer


    RAD51 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD51 (see all 6): 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD51

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD51 (Q066091, 2, 3 ENSP000002678684) via UniProtKB, MINT, STRING, and/or I2D (see all 477)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BRCA2P515871, 2, 3, ENSP000003694974EBI-297202,EBI-79792 MINT-8176347 MINT-8361862 MINT-8384735 MINT-4980518 MINT-8329250 MINT-8303499 MINT-4980488 MINT-4980408 MINT-8384781 MINT-8385051 MINT-8385019 MINT-8384999 MINT-8384801 MINT-8176308 MINT-8329389 MINT-4980796 MINT-4980473 MINT-8329289 MINT-8176323 MINT-4980567 MINT-8384752 MINT-4980502 I2D: score=10 STRING: ENSP00000369497
    RAD52P433511, 2, 3, ENSP000003512844EBI-297202,EBI-706448 MINT-6550637 I2D: score=4 STRING: ENSP00000351284
    PALB2Q86YC22, 3, ENSP000002615844MINT-8361862 MINT-8385019 MINT-8384999 MINT-8329389 MINT-8384781 MINT-8329250 MINT-8329289 I2D: score=1 STRING: ENSP00000261584
    BRCA1P383982, 3, ENSP000003502834MINT-8361862 MINT-8329250 MINT-8329389 MINT-8329289 I2D: score=4 STRING: ENSP00000350283
    H2AFXP161042, 3, ENSP000003643104MINT-8149318 MINT-8361862 MINT-8149329 I2D: score=3 STRING: ENSP00000364310
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000724double-strand break repair via homologous recombination TAS12427746
    GO:0000730DNA recombinase assembly TAS--
    GO:0006200ATP catabolic process IDA7988572
    GO:0006259DNA metabolic process ----
    GO:0006268DNA unwinding involved in DNA replication IDA7988572

    RAD51 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD51

    1 DrugBank Compound for RAD51    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphoaminophosphonic Acid-Adenylate Ester-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for RAD51 gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atpgammas 83 49 9201926 (3), 9718317 (3), 1507222 (2), 8325858 (2) (see all 31)
    adenosine 5'-o-(3-thiotriphosphate) 79.9 18 2195545 (1), 7882996 (1), 8045304 (1), 2188972 (1) (see all 15)
    5-formyl-2'-deoxyuridine 74.4 6 12836321 (2), 11562961 (1), 12903258 (1), 14611842 (1)
    atp 67.7 210 11342134 (6), 9012806 (4), 9201926 (4), 15719060 (4) (see all 87)
    mitomycin c 62.4 15 11684015 (1), 16825569 (1), 20042515 (1), 10373565 (1) (see all 12)
    adp 47.8 43 12758082 (4), 11839740 (3), 15123651 (3), 16624636 (2) (see all 21)
    inosine triphosphate 46.3 8 1606138 (3), 1606139 (2)
    methylmethanesulfonate 46.1 6 9560268 (3), 18375193 (1), 7892263 (1)
    amp-pnp 42.6 3 19622740 (2), 9718317 (1)
    rpa 2 41.8 1 15326288 (1)



    RAD51 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for RAD51 gene (4 alternative transcripts): 
    NM_001164269.1  NM_001164270.1  NM_002875.4  NM_133487.3  

    Unigene Cluster for RAD51:

    RAD51 homolog (S. cerevisiae)
    Hs.631709  [show with all ESTs]
    Unigene Representative Sequence: NM_133487
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000527860 ENST00000423169 ENST00000267868(uc001zmi.4 uc010bbw.3 uc010bbx.3 uc001zml.4)
    ENST00000557850 ENST00000532743(uc001zmn.1) ENST00000382643 ENST00000525066
    ENST00000526763 ENST00000531277(uc001zmm.1) ENST00000533741 ENST00000530766

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat RAD51 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD51 (see all 12):
    hsa-miR-3164 hsa-miR-548d-3p hsa-miR-631 hsa-miR-134 hsa-miR-3661 hsa-miR-888* hsa-miR-221* hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidRAD51 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat RAD51
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    OriGene ORF clones in mouse, rat for RAD51
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): RAD51 (NM_002875)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD51
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD51
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for RAD51
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD51
      QuantiTect SYBR Green Assays in human, mouse, rat RAD51
      QuantiFast Probe-based Assays in human, mouse, rat RAD51

    Additional mRNA sequence: 

    AK131299.1 AK291969.1 AK303089.1 AK313503.1 AY425955.1 AY608888.1 BC001459.2 BT019705.1 
    CR536559.1 D13804.1 D14134.1 EU362635.1 

    10 DOTS entries:

    DT.209091  DT.95254199  DT.95254169  DT.92452043  DT.121050424  DT.95085123  DT.91749880  DT.100777886 
    DT.121050426  DT.95254167 

    Selected AceView cDNA sequences (see all 118):

    BU624430 BC001459 BM910438 AY608888 CR536559 CR594665 BM791694 CR626167 
    BU164989 CR619182 AU100170 AU107551 BE280848 BQ424388 CR606487 CR622784 
    AW363521 BX494877 BG474115 BM808716 AI347079 BM810067 AW006523 CN481135 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD51    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                    -     -                             -                                                   
    SP2:                          -                 -     -                                                         
    SP3:                          -                 -     -     -                                                   
    SP4:                          -                                                                                 
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for RAD51

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    RAD51 expression in normal human tissues (normalized intensities)      RAD51 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTTAGG
    RAD51 Expression
    About this image


    RAD51 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Mesencephalic Ventricular Zone
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             XX Germ Cells Ovigerous Cord
             Oviduct
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Bone (Muscoskeletal System)
             Bone Marrow
    RAD51 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD51 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631709

    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
    Tissue specificity: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas
    and ovary. Weakly expressed in breast

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD51 (see all 6): 
              Cell Cycle in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat
              Ubiquitin Ligases in human mouse rat
              Stress & Toxicity PathwayFinder in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD51

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD51 gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad511 , 5 RAD51 homolog (S. cerevisiae)5
    RAD51 homolog1
    91.05(n)1
    98.82(a)1
      2 (59.92 cM)5
    193611  NM_011234.41  NP_035364.11 
     1191127935 
    chicken
    (Gallus gallus)
    Aves RAD511 RAD51 homolog (S. cerevisiae) 81.51(n)
    95.58(a)
      396086  NM_205173.1  NP_990504.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD516
    RAD51 recombinase
    86(a)
    1 ↔ 1
    GL343264.1(638487-655671)
    African clawed frog
    (Xenopus laevis)
    Amphibia rad51-prov2 RAD51 homolog (S. cerevisiae) 79.47(n)    BC046650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb38e122 Danio rerio RAD51 homolog, mRNA (cDNA clone MGC77754 more 79.07(n)    BC062849.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad513
    spn-A1
    DNA recombination DNA dependent
    adenosinetriphosphatase3
    spindle A1
    68(a)3
    65.11(n)1
    68.63(a)1
      3 99D33
    435771  NM_079844.41  NP_524583.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rad-511 , 3 Helix-hairpin-helix motif.3
    rad-511
    59(a)3
    58.19(n)1
    59.17(a)1
      IV(10282150-10284418)3
    1779141  NM_001028294.21  NP_001023465.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD51(YER095W)4
    RAD511
    Strand exchange protein, forms a helical filament with more4
    RAD511
    60.2(n)1
    67.76(a)1
      5(349980-351182)4
    8568311, 4  NP_011021.31  NP_011021.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD511 RAD51 66.05(n)
    71.3(a)
      832208  NM_122092.2  NP_568402.1 
    rice
    (Oryza sativa)
    Liliopsida Os.196302 Oryza sativa (japonica cultivar-group) OsRad51A2 mRNA more 75.67(n)    AB080264.1 


    ENSEMBL Gene Tree for RAD51 (if available)
    TreeFam Gene Tree for RAD51 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD51 gene
    Selected SIMAP similar genes for RAD51 using alignment to 6 protein entries:     RAD51_HUMAN (see all proteins) (see all similar genes):
    C1orf143    ZNF799    IRF2    ARL6IP5    SLC35E3    AARSD1
    ZNF257    ATL2    LDLRAD3    EIF3G    EEF1E1    HDGFRP2
    PARK2    RRM2B    SEPSECS    ADCK1    DMC1    TMX3

    RAD51 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for RAD51 (see all 863)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219177391,2,,4
    C,FBreast cancer (BC)4 pathogenic121078687(+) TGACCG/AGGGTG 8 /Q /R mis11Minor allele frequency- A:0.00NA 4552
    rs455602351,2
    C,F--17833231(+) ACCTCG/ATGATC 4 -- us2k11Minor allele frequency- A:0.03NS 176
    rs559436601,2
    C--17845843(+) TATAT-/ATTTTT 4 -- int10--------
    rs1485709211,2
    C--17862633(+) GGGGA-/GTTGTTGT 4 -- int10--------
    rs455465371,2
    F--17862639(+) TTGTTGTT/-TAATG 8 -- int1 cds11Minor allele frequency- -:0.08NS 176
    rs340861101,2
    C--17864995(+) TTTAA-/TTTTTT 4 -- int12Minor allele frequency- T:0.25NA 4
    rs2014725591,2
    C--17870565(+) TTTTTC/TTTTTT 4 -- int10--------
    rs1447208251,2
    --21052998(+) GAAAAC/TAGATC 4 -- us2k10--------
    rs1846440321,2
    --21053131(+) AGTGGC/TGTGAT 4 -- us2k10--------
    rs1874715381,2
    --21053225(+) CACCAC/TGCCCG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD51 (40986972 - 41024356 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for RAD51:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2478123CNV Deletion19546169
    nsv904100CNV Loss21882294
    nsv529030CNV Loss19592680
    nsv904099CNV Loss21882294
    nsv527234CNV Loss19592680
    nsv904101CNV Loss21882294
    nsv832984CNV Loss17160897
    dgv739e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): RAD51
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD51
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD51

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 179617   
    OMIM disorders: 114480  614508  
    UniProtKB/Swiss-Prot: RAD51_HUMAN, Q06609
  • Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast
    neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common
    type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated
    by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different
    families or even in the same case. Note=Disease susceptibility is associated with variations affecting the gene
    represented in this entry
  • Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements
    that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond
    the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for RAD51 (see all 76):    About MalaCards
    breast cancer susceptibility    mirror movements 1    bilateral breast cancer    bloom syndrome
    chronic lymphocytic leukemia    breast-ovarian cancer, familial, 2    familial chronic lymphocytic leukemia    brca1 and brca2 hereditary breast and ovarian cancer
    brca2 hereditary breast and ovarian cancer    breast cancer    hereditary breast ovarian cancer    acoustic neuroma
    neuroma    hereditary pancreatitis    brain cancer    barrett's adenocarcinoma
    familial breast cancer    fanconi's anemia    nijmegen breakage syndrome    werner syndrome

    4 diseases from the University of Copenhagen DISEASES database for RAD51:
    Aplastic anemia     Breast cancer     Ovarian cancer     Autosomal recessive disease

    RAD51 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for RAD51 gene (see all 26)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconis anemia 66.7 7 12239151 (1), 12483114 (1)
    bloom syndrome 64.4 4 12975363 (1), 10767546 (1), 19632996 (1), 15143192 (1)
    ataxia telangiectasia 50.6 2 15135073 (1), 9315668 (1)
    breast cancer 50.3 94 16762046 (7), 18974064 (6), 12673366 (5), 17707537 (3) (see all 42)
    germ-line mutation 47.4 2 20002770 (1), 10463575 (1)
    ovarian cancer 38.9 10 11535547 (3), 16005565 (2), 10197592 (1), 16165098 (1) (see all 5)
    cancer 37.9 40 19106292 (4), 20002770 (2), 15150571 (2), 18618591 (2) (see all 27)
    tumors 27.2 63 16596227 (5), 11782381 (5), 16234517 (4), 18243065 (3) (see all 32)
    bilateral breast cancer 26.3 2 17666788 (1), 10807537 (1)
    chromosomal aberrations 24.7 2 11283264 (1), 16511829 (1)

    Genetic Association Database (GAD): RAD51
    Human Genome Epidemiology (HuGE) Navigator: RAD51 (104 documents)

    Export disorders for RAD51 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD51 gene, integrated from 10 sources (see all 823):
    (articles sorted by number of sources associating them with RAD51)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PubMed id 11535547)1, 2, 4, 9 Wang W.W.... Struewing J.P. (Cancer Epidemiol. Biomarkers Prev. 2001)
    2. Cloning and sequence of the human RecA-like gene cDNA. (PubMed id 8479919)1, 2, 3 Yoshimura Y.... Matsushiro A. (Nucleic Acids Res. 1993)
    3. Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA. (PubMed id 8358431)1, 2, 3 Shinohara A.... Ogawa T. (Nat. Genet. 1993)
    4. A novel human Rad54 homologue, Rad54B, associates with Rad51. (PubMed id 10851248)1, 2, 9 Tanaka K.... Miyagawa K. (J. Biol. Chem. 2000)
    5. Regulation of Rad51 function by c-Abl in response to DNA damage. (PubMed id 9461559)1, 2, 9 Yuan Z.M....Kufe D. (J. Biol. Chem. 1998)
    6. Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA. (PubMed id 7988572)1, 2, 9 Benson F.E.... West S.C. (EMBO J. 1994)
    7. Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. (PubMed id 18974064)1, 4, 9 Ding S.L....Shen C.Y. (Carcinogenesis 2009)
    8. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. (PubMed id 9192668)1, 2, 9 Mizuta R.... Alt F.W. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    9. Polymorphism of the homologous recombination repair genes RAD51 and XRCC3 in breast cancer. (PubMed id 19426727)1, 4, 9 Krupa R....Blasiak J. (Exp. Mol. Pathol. 2009)
    10. [Association of polymorphisms of N372H in BRCA2 gene and 135G/C in RAD51 gene and breast cancers]. (PubMed id 19253839)1, 4, 9 Hu R....Tang X.L. (Sichuan Da Xue Xue Bao Yi Xue Ban 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5888 HGNC: 9817 AceView: RAD51 Ensembl:ENSG00000051180 euGenes: HUgn5888
    ECgene: RAD51 Kegg: 5888 H-InvDB: RAD51

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD51 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD51 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad51/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD51 gene:
    Search GeneIP for patents involving RAD51

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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