Aliases for RAD51 Gene
External Ids for RAD51 Gene
Previous HGNC Symbols for RAD51 Gene
Previous GeneCards Identifiers for RAD51 Gene
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for RAD51 Gene
RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include mirror movements 2 and breast cancer. Among its related pathways are Fanconi anemia pathway and Homologous recombination. GO annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is RAD51B.
UniProtKB/Swiss-Prot for RAD51 Gene
Participates in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA and forms helical nucleoprotein filaments. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.