Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



RAD50 Gene

protein-coding   GIFtS: 67
GCID: GC05P131920

RAD50 Homolog (S. Cerevisiae)

(Previous name: RAD50 (S. cerevisiae) homolog)
  See RAD50-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
RAD50 Homolog (S. Cerevisiae)1 2     EC 3.6.-.-3
NBSLD2 5     hRAD503
RAD50 (S. Cerevisiae) Homolog1     EC 3.6.1.158
RAD5022     EC 3.6.38
DNA Repair Protein RAD502     EC 3.6.3.278
hRad502     

External Ids:    HGNC: 98161   Entrez Gene: 101112   Ensembl: ENSG000001135227   OMIM: 6040405   UniProtKB: Q928783   

Export aliases for RAD50 gene to outside databases

Previous GC identifers: GC05P131414 GC05P132339 GC05P131923 GC05P131968 GC05P127084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for RAD50 Gene:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA
double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA
and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein,
cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation,
telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is
essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like
disorder.(provided by RefSeq, Apr 2010)

GeneCards Summary for RAD50 Gene:
RAD50 (RAD50 homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD50 include nijmegen breakage syndrome-like disorder, and nijmegen breakage syndrome. GO annotations related to this gene include 3'-5' exonuclease activity and protein binding, bridging.

UniProtKB/Swiss-Prot: RAD50_HUMAN, Q92878
Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be
required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long
regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases
and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The
complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN
complex may modulate t-loop formation

Gene Wiki entry for RAD50 (Rad50) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD50 gene promoter:
         GR   p53   GATA-3   GR-beta   POU3F2 (N-Oct-5b)   C/EBPalpha   GATA-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidRAD50 promoter sequence
   Search Chromatin IP Primers for RAD50

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD50


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q23-q31

RAD50 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD50 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P131920:  view genomic region     (about GC identifiers)

Start:
131,891,711 bp from pter      End:
131,980,313 bp from pter
Size:
88,603 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RAD50_HUMAN, Q92878 (See protein sequence)
Recommended Name: DNA repair protein RAD50  
Size: 1312 amino acids; 153892 Da
Cofactor: Binds 1 zinc ion per homodimer (By similarity)
Subunit: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN.
Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN.
Found in a complex with TERF2. Interacts with RINT1. Interacts with BRCA1 via its N-terminal domain. Interacts
with DCLRE1C/Artemis
Miscellaneous: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral
oncoproteins, thereby preventing concatenation of viral genomes in infected cells
Sequence caution: Sequence=AAH62603.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: B9EGF5 O43254 Q6GMT7 Q6P5X3 Q9UP86
Alternative splicing: 3 isoforms:  Q92878-1   Q92878-2   Q92878-3   

Explore the universe of human proteins at neXtProt for RAD50: NX_Q92878

Explore proteomics data for RAD50 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62, Lys175, Lys187, Lys211, Lys295, Lys461, Lys845, Lys1119, Lys1134, Lys1285
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for RAD50 (Q92878)
     KDLDIYY  NGAGKTT  GPNGAGKT  ELSKAEKN 


    See RAD50 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005723.2  
    ENSEMBL proteins: 
     ENSP00000389515   ENSP00000431225   ENSP00000265335   ENSP00000400049   ENSP00000390971  
     ENSP00000396100   ENSP00000396860   ENSP00000368100  
    Reactome Protein details: Q92878

    RAD50 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for RAD50
    OriGene Custom MassSpec
    OriGene Custom Protein Services for RAD50
    GenScript Custom Purified and Recombinant Proteins Services for RAD50
    Novus Biologicals RAD50 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD50

     
    Search eBioscience for Proteins for RAD50 

     
    antibodies-online proteins for RAD50 (4 products) 

     
    antibodies-online peptides for RAD50

    RAD50 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD50
    R&D Systems Antibodies for RAD50
    Cell Signaling Technology (CST) Antibodies for RAD50 
    OriGene Antibodies for RAD50
    OriGene Custom Antibody Services for RAD50
    Novus Biologicals RAD50 Antibodies
    Abcam antibodies for RAD50
    Cloud-Clone Corp. Antibodies for RAD50
    ThermoFisher Antibodies for RAD50
    LSBio Antibodies in human, mouse, rat for RAD50
    antibodies-online antibodies for RAD50 (61 products) 

    RAD50 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for RAD50
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for RAD50
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for RAD50
    Cloud-Clone Corp. CLIAs for RAD50
    Search eBioscience for ELISAs for RAD50 
    antibodies-online kits for RAD50 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR004584 Rad50_eukaryotes
     IPR013134 Zn_hook_Rad50
     IPR027417 P-loop_NTPase
     IPR007517 Rad50_Zn_hook

    Graphical View of Domain Structure for InterPro Entry Q92878

    ProtoNet protein and cluster: Q92878

    1 Blocks protein domain: IPB007517 Rad50 zinc hook motif

    UniProtKB/Swiss-Prot: RAD50_HUMAN, Q92878
    Domain: The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that
    coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule,
    thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain,
    interact with the MRE11A homodimer (By similarity)
    Similarity: Belongs to the SMC family. RAD50 subfamily
    Similarity: Contains 1 zinc-hook domain


    Find genes that share domains with RAD50           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD50_HUMAN, Q92878
    Function: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA
    recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease
    activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be
    required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long
    regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases
    and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The
    complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN
    complex may modulate t-loop formation

         Genatlas biochemistry entry for RAD50:
    RAD50 (S cerevisiae) homolog,involved in DNA recombinational repair and meiosis specific double strand break
    formation,complexing with MR11 and NBS1

         Enzyme Numbers (IUBMB): EC 3.6.3.272 EC 3.6.32 EC 3.6.-.-1 EC 3.6.1.152

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000014contributes to single-stranded DNA endodeoxyribonuclease activity IDA9705271
    GO:0003677DNA binding IDA15790808
    GO:0004003contributes to ATP-dependent DNA helicase activity IMP15790808
    GO:0004518nuclease activity ----
    GO:0005515protein binding IPI11096100
         
    Find genes that share ontologies with RAD50           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 8 alleles(MGI details for Rad50):
     behavior/neurological  cellular  embryogenesis  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  immune system  liver/biliary system  mortality/aging  nervous system 
     reproductive system  respiratory system  tumorigenesis 

    Find genes that share phenotypes with RAD50           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad50tm1Jpt for RAD50

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD50
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD50

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD50
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD50

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat RAD50 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RAD50:
    hsa-miR-3158-3p hsa-miR-3164 hsa-miR-3658 hsa-miR-1207-3p hsa-miR-183 hsa-miR-590-3p hsa-miR-450b-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidRAD50 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD50
    Predesigned siRNA for gene silencing in human, mouse, rat RAD50

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for RAD50

    Clone
    Products:
         
    OriGene clones in human, mouse for RAD50 (see all 8)
    OriGene ORF clones in mouse, rat for RAD50
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAD50 (NM_005732)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD50
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD50

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for RAD50
    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD50 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD50


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RAD50_HUMAN, Q92878: Nucleus. Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with
    genotoxic agents
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000784nuclear chromosome, telomeric region IDA10888888
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0030870Mre11 complex IDA19151086

    Find genes that share ontologies with RAD50           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for RAD50 About   (see all 20)  
    See pathways by source

    SuperPathContained pathways About
    1Non-homologous end-joining
    Non-homologous end-joining0.37
    Non-homologous end joining0.00
    DNA damage NHEJ mechanisms of DSBs repair0.37
    2Homologous recombination
    Homologous recombination0.40
    Homologous recombination0.40
    3Homologous Recombination Repair
    Homologous Recombination Repair0.70
    Recruitment of repair and signaling proteins to double-strand breaks0.00
    Double-Strand Break Repair0.70
    Homologous recombination repair of replication-independent double-strand breaks0.00
    4Cellular Senescence
    Cellular Senescence0.81
    Cellular responses to stress0.81
    5Meiosis (REACTOME)
    Meiosis0.74
    Meiotic Recombination0.74


    Find genes that share SuperPaths with RAD50           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for RAD50 (see all 6)
        ATM Pathway
    Fanconi's Anaemia Pathway
    BRCA1 Pathway
    DNA Repair Mechanisms
    Chks in Checkpoint Regulation

    2 Cell Signaling Technology (CST) Pathways for RAD50
        Cell Cycle / Checkpoint Control
    DNA Damage

    2 GeneGo (Thomson Reuters) Pathways for RAD50
        DNA damage Role of Brca1 and Brca2 in DNA repair
    DNA damage NHEJ mechanisms of DSBs repair

    Selected BioSystems Pathways for RAD50 (see all 9)
        DNA damage response
    Homologous recombination
    Integrated Breast Cancer Pathway
    Non-homologous end joining
    Integrated Pancreatic Cancer Pathway

    3 Reactome Pathways for RAD50
        Meiotic recombination
    Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks
    DNA Damage/Telomere Stress Induced Senescence


    2 Kegg Pathways  (Kegg details for RAD50):
        Homologous recombination
    Non-homologous end-joining

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD50: 
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD50

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD50 (Q928782, 3 ENSP000002653354) via UniProtKB, MINT, STRING, and/or I2D (see all 1056)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146762, 3, ENSP000003730604MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 STRING: ENSP00000373060
    ENSG00000237095Q146762, 3, ENSP000004091674MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 STRING: ENSP00000409167
    NBNO609342, 3, ENSP000002654334MINT-6805435 MINT-6805527 MINT-7231018 MINT-6805327 MINT-7906622 MINT-6805250 MINT-6805281 MINT-7906581 MINT-7906646 MINT-7947479 MINT-6805304 MINT-7945693 MINT-6805376 MINT-7906600 I2D: score=6 STRING: ENSP00000265433
    ENSG00000224587Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    ENSG00000225589Q146762, 3MINT-6805435 MINT-6805527 MINT-6805327 MINT-6805250 MINT-6805281 MINT-6805549 MINT-6805304 MINT-6805376 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000019regulation of mitotic recombination IDA8756642
    GO:0000723telomere maintenance TAS10888888
    GO:0000724double-strand break repair via homologous recombination TAS--
    GO:0000737DNA catabolic process, endonucleolytic IDA9705271
    GO:0006281DNA repair TAS--

    Find genes that share ontologies with RAD50           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD50

    8 Novoseek inferred chemical compound relationships for RAD50 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tin(2+) 79.8 2 12007281 (1), 18077792 (1)
    mononucleotide 71.4 3 16025146 (1), 16542220 (1), 11196187 (1)
    methylmethanesulfonate 53.2 1 12944481 (1)
    camptothecin 49 3 18075304 (1)
    hydroxyurea 38.4 1 12944481 (1)
    atp 0.0662 8 14698290 (3), 19308707 (2), 10346816 (1)
    nitric oxide 0 7 14550546 (3)
    serine 0 2 14698290 (2)



    Find genes that share compounds with RAD50           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for RAD50 gene (2 alternative transcripts): 
    NM_005732.3  NM_133482.1  

    Unigene Cluster for RAD50:

    RAD50 homolog (S. cerevisiae)
    Hs.633509  [show with all ESTs]
    Unigene Representative Sequence: NM_005732
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416135(uc003kxg.1) ENST00000533482 ENST00000265335 ENST00000453394
    ENST00000423956 ENST00000487596 ENST00000434288 ENST00000496204 ENST00000489420
    ENST00000455677 ENST00000378823(uc003kxi.3 uc003kxh.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat RAD50 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate RAD50:
    hsa-miR-3158-3p hsa-miR-3164 hsa-miR-3658 hsa-miR-1207-3p hsa-miR-183 hsa-miR-590-3p hsa-miR-450b-5p hsa-miR-4257
    SwitchGear 3'UTR luciferase reporter plasmidRAD50 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for RAD50
    Predesigned siRNA for gene silencing in human, mouse, rat RAD50
    Clone
    Products:
         
    OriGene clones in human, mouse for RAD50 (see all 8)
    OriGene ORF clones in mouse, rat for RAD50
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAD50 (NM_005732)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD50
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD50
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD50
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD50
      QuantiTect SYBR Green Assays in human, mouse, rat RAD50
      QuantiFast Probe-based Assays in human, mouse, rat RAD50

    Additional mRNA sequence: 

    AF057299.1 AF057300.1 AK290597.1 AK307439.1 BC062603.1 BC073850.1 BC108282.1 BC136436.1 
    BC140005.1 DQ655928.2 U63139.1 

    Selected DOTS entries (see all 25):

    DT.100781410  DT.214264  DT.100781409  DT.120846100  DT.97762068  DT.120846103  DT.120846112  DT.100781411 
    DT.120846145  DT.75126706  DT.107197  DT.120846084  DT.40232006  DT.120846194  DT.120846236  DT.92436975 
    DT.120846028  DT.120846090  DT.120846255  DT.40127609  DT.91849555  DT.92436969  DT.101971429  DT.102913 

    Selected AceView cDNA sequences (see all 196):

    BU634308 CA448870 AA908963 AU122773 NM_133482 CB152639 AA741068 BM698750 
    BQ018245 AW024230 BM013995 BX501770 BM988308 BU740393 AA311726 BU619256 
    NM_005732 U63139 BQ716207 BU618983 CB306651 AL037130 BC062603 BF060755 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for RAD50    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                      -                                                                                                                     
    SP2:                          -           -                                                                                                                     
    SP3:                                                                                                                                                            

    ExUns: 23 ^ 24 ^ 25a · 25b
    SP1:                        
    SP2:                        
    SP3:                        


    ECgene alternative splicing isoforms for RAD50

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    RAD50 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGCCCCGTT
    RAD50 Expression
    About this image


    RAD50 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    RAD50 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD50 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633509

    UniProtKB/Swiss-Prot: RAD50_HUMAN, Q92878
    Tissue specificity: Expressed at very low level in most tissues, except in testis where it is expressed at higher
    level. Expressed in fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Arrays including RAD50: 
              DNA Damage Signaling Pathway in human mouse rat
              Telomeres & Telomerase in human mouse rat
              DNA Repair in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD50
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD50
    QuantiTect SYBR Green Assays in human, mouse, rat RAD50
    QuantiFast Probe-based Assays in human, mouse, rat RAD50
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD50

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD50 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad501 , 5 RAD50 homolog (S. cerevisiae)1, 5 87.91(n)1
    92.3(a)1
      11 (31.98 cM)5
    193601  NM_009012.21  NP_033038.21 
     536495195 
    chicken
    (Gallus gallus)
    Aves RAD501 RAD50 homolog (S. cerevisiae) 74.8(n)
    77.13(a)
      416329  XM_004945015.1  XP_004945072.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD506
    RAD50 homolog (S. cerevisiae)
    79(a)
    1 ↔ 1
    2(127651281-127701239)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480364802   -- 74.5(n)    48036480 
    zebrafish
    (Danio rerio)
    Actinopterygii rad501 RAD50 homolog (S. cerevisiae) 67.35(n)
    70.96(a)
      553029  XM_005167938.1  XP_005167995.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rad501 , 3 DNA repair3
    rad501
    28(a)3
    44.33(n)1
    30.87(a)1
      58E13
    375641  NM_001259532.11  NP_001246461.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rad-503 DNA repair protein RAD50 like 25(a)   V(12249212-12253655)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD50(YNL250W)4 Subunit of MRX complex, with Mre11p and Xrs2p, involved more   --   14(175410-179348) 855471  NP_014149.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD501 RAD50 46.84(n)
    34.84(a)
      817756  NM_128757.3  NP_565733.1 
    rice
    (Oryza sativa)
    Liliopsida Os.72972 Oryza sativa (japonica cultivar-group) DNA repair-recombination more 72.62(n)    AY277897.1 


    ENSEMBL Gene Tree for RAD50 (if available)
    TreeFam Gene Tree for RAD50 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for RAD50 (see all 1745)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747697211,2
    C,Funtested1132188270(+) CTGGTG/ACTTAT 1 -- int12Minor allele frequency- A:0.01WA EU 1291
    rs1048950431,2
    Cuntested1132191691(+) AATAGC/TTTAAG 1 -- int10--------
    rs756396321,2
    C,Funtested1132192124(+) AAAAAA/GTTTAA 1 -- int11Minor allele frequency- G:0.07NA 120
    rs1048950451,2
    C,Funtested1132201187(+) AGCACC/TAGTTG 1 -- int11Minor allele frequency- T:0.03NA 120
    rs1048950471,2
    Cuntested1132221122(+) ATATTA/GTATAA 1 -- int10--------
    rs1048950481,2
    Cuntested1132228703(+) ATAAAC/TGTCTT 1 -- int11Minor allele frequency- T:0.00EU 1269
    rs1048950501,2
    Cuntested1132230604(+) TTTTTA/TCAGTG 1 -- int10--------
    rs77057401,2
    C--127086668(+) cccccA/Ccaaaa 1 -- int10--------
    rs27063521,2
    C,F--127103260(+) taaaaC/Acatca 1 -- int11Minor allele frequency- A:0.27WA 118
    rs2004192711,2
    C--131891684(-) AGGTTA/TAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for RAD50 (131891711 - 131980313 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for RAD50: --
    Human Gene Mutation Database (HGMD): RAD50
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD50
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD50

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604040   
    OMIM disorders: 613078  
    UniProtKB/Swiss-Prot: RAD50_HUMAN, Q92878
  • Nijmegen breakage syndrome-like disorder (NBSLD) [MIM:613078]: A disorder similar to Nijmegen breakage
    syndrome and characterized by chromosomal instability, radiation sensitivity, microcephaly, growth retardation,
    short stature and bird-like face. Immunodeficiency is absent. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 5 diseases for RAD50:    
    About MalaCards
    nijmegen breakage syndrome-like disorder    nijmegen breakage syndrome    breast-ovarian cancer, familial, 2    ataxia telangiectasia
    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for RAD50:
    Nijmegen breakage syndrome     Ataxia telangiectasia     Microcephaly     Fanconi's anemia

    Find genes that share disorders with RAD50           About GenesLikeMe

    Selected Novoseek inferred disease relationships for RAD50 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nijmegen breakage syndrome 88.6 5 10888888 (1), 15026416 (1), 9705271 (1), 10346816 (1) (see all 5)
    ataxia telangiectasia 70.8 4 16971555 (1), 15064416 (1), 17932350 (1), 17429352 (1)
    microsatellite instability 59.7 2 11196187 (1), 18606567 (1)
    fanconis anemia 45.5 2 17524422 (2)
    colorectal cancer 32.7 1 18830935 (1)
    breast cancer 26.4 13 16385572 (5), 16474176 (1), 17292821 (1), 19383352 (1) (see all 6)
    cancer 22.6 6 18606567 (2), 16385572 (1), 12957814 (1), 17143500 (1) (see all 5)
    tumors 17.2 19 16025146 (3), 14550546 (2), 18606567 (2), 12654199 (1) (see all 11)
    gastric carcinoma 8.26 4 12007281 (3), 11196187 (1)
    carcinoma 0 1 12007281 (1)

    Genetic Association Database (GAD): RAD50
    Human Genome Epidemiology (HuGE) Navigator: RAD50 (31 documents)

    Export disorders for RAD50 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for RAD50 gene, integrated from 10 sources (see all 264):
    (articles sorted by number of sources associating them with RAD50)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair. (PubMed id 8756642)1, 2, 3, 9 Dolganov G.M.... Petrini J.H.J. (Mol. Cell. Biol. 1996)
    2. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. (PubMed id 9705271)1, 2, 3, 9 Trujillo K.M.... Sung P. (J. Biol. Chem. 1998)
    3. Molecular cloning and characterization of splice variants of human RAD50 gene. (PubMed id 10415333)1, 2, 9 Kim K.K....Park B.R. (Gene 1999)
    4. Evaluation of RAD50 in familial breast cancer predisposition. (PubMed id 16385572)1, 4, 9 Tommiska J....Rahman N. (Int. J. Cancer 2006)
    5. RINT-1, a novel Rad50-interacting protein, participates in radiation- induced G2/M checkpoint control. (PubMed id 11096100)1, 2, 9 Xiao J.... Lee W.-H. (J. Biol. Chem. 2001)
    6. Genetic variation in the NBS1, MRE11, RAD50 and BLM genes and susceptibility to non-Hodgkin lymphoma. (PubMed id 19917125)1, 4, 9 Schuetz J.M....Brooks-Wilson A.R. (BMC Med. Genet. 2009)
    7. Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. (PubMed id 10888888)1, 2, 9 Zhu X.-D.... de Lange T. (Nat. Genet. 2000)
    8. Association of BRCA1 with the hRad50-hMre11-p95 complex and the DNA damage response. (PubMed id 10426999)1, 2, 9 Zhong Q.... Lee W.-H. (Science 1999)
    9. Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex. (PubMed id 17932350)1, 4, 9 Hsu H.M....Yu J.C. (amp 2007)
    10. DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. (PubMed id 12384589)1, 2, 9 de Jager M.... Kanaar R. (Nucleic Acids Res. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10111 HGNC: 9816 AceView: RAD50 Ensembl:ENSG00000113522 euGenes: HUgn10111
    ECgene: RAD50 Kegg: 10111 H-InvDB: RAD50

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for RAD50 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD50 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for RAD50 gene:
    Search GeneIP for patents involving RAD50

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of RAD50
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for RAD50 (Rad50)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for RAD50   OriGene RNAi products in human, mouse, rat for RAD50  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for RAD50  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for RAD50  
     OriGene qSTAR qPCR primer pairs in human, mouse for RAD50   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for RAD50   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for RAD50   OriGene Custom Protein Services for RAD50  

     
     
     Block miRNA regulation of human, mouse, rat RAD50 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing RAD50
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD50 Predesigned siRNA for gene silencing in human, mouse, rat RAD50
     QuantiFast Probe-based Assays in human, mouse, rat RAD50 QuantiTect SYBR Green Assays in human, mouse, rat RAD50
     PCR Arrays including human, mouse, rat RAD50 Search Chromatin IP Primers for RAD50
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat RAD50  GeneGlobe Interaction Network for RAD50
     Regulatory tfbs in RAD50 promoter
     GenScript Custom Purified and Recombinant Proteins Services for RAD50 GenScript cDNA clones with any tag delivered in your preferred vector for RAD50
     GenScript Custom Assay Services for RAD50 GenScript Custom overexpressing Cell Line Services for RAD50
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for RAD50 

     Search Tocris compounds for RAD50
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     RAD50 antibodies
     RAD50 lysates
     Antibodies for RAD50
     See all of Abcam's Antibodies, Kits and Proteins for RAD50
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for RAD50
     Antibodies for RAD50
     ELISAs for RAD50
     CLIAs for RAD50



     Browse ESI BIO Cell Lines and PureStem Progenitors for RAD50
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD50
     SwitchGear 3'UTR luciferase reporter plasmids for RAD50
     SwitchGear Promoter luciferase reporter plasmids for RAD50
     ThermoFisher Antibodies for RAD50
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD50
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD50
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD50
     LSBio Antibodies in human, mouse, rat for RAD50
     Browse compounds at ApexBio
     Search Addgene for plasmids for RAD50
      Search eBioscience for proteins for RAD50
      Search eBioscience for elisas for RAD50
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for RAD50 (61 products)
     antibodies-online kits for RAD50 (10 products)
     antibodies-online peptides for RAD50
     antibodies-online proteins for RAD50 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      RAD50 gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4