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Aliases for RAD23B Gene

Aliases for RAD23B Gene

  • RAD23 Homolog B (S. Cerevisiae) 2 3
  • XP-C Repair-Complementing Complex 58 KDa Protein 3 4
  • XP-C Repair Complementing Complex 58 KDa 2 3
  • XP-C Repair Complementing Protein 2 3
  • HHR23B 3 4
  • HR23B 3 4
  • P58 3 4
  • UV Excision Repair Protein RAD23 Homolog B 3
  • RAD23 (S. Cerevisiae) Homolog B 2
  • RAD23, Yeast Homolog Of, B 3

External Ids for RAD23B Gene

Previous GeneCards Identifiers for RAD23B Gene

  • GC09P100840
  • GC09P101777
  • GC09P103503
  • GC09P105425
  • GC09P107125
  • GC09P109085
  • GC09P110045
  • GC09P079647

Summaries for RAD23B Gene

Entrez Gene Summary for RAD23B Gene

  • The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

GeneCards Summary for RAD23B Gene

RAD23B (RAD23 Homolog B (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with RAD23B include xeroderma pigmentosum, group c and mutagen sensitivity. Among its related pathways are Chks in Checkpoint Regulation and DNA Repair. GO annotations related to this gene include single-stranded DNA binding and polyubiquitin binding. An important paralog of this gene is RAD23A.

UniProtKB/Swiss-Prot for RAD23B Gene

  • Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome

  • Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation

  • The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5-to-3 direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5 and 3 of a cisplatin lesion with a preference for the 5 side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1

Gene Wiki entry for RAD23B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD23B Gene

Genomics for RAD23B Gene

Regulatory Elements for RAD23B Gene

Genomic Location for RAD23B Gene

Start:
107,283,137 bp from pter
End:
107,332,194 bp from pter
Size:
49,058 bases
Orientation:
Plus strand

Genomic View for RAD23B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD23B Gene

Proteins for RAD23B Gene

  • Protein details for RAD23B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54727-RD23B_HUMAN
    Recommended name:
    UV excision repair protein RAD23 homolog B
    Protein Accession:
    P54727
    Secondary Accessions:
    • B3KWK8
    • G5E9P0
    • Q7Z5K8
    • Q8WUB0

    Protein attributes for RAD23B Gene

    Size:
    409 amino acids
    Molecular mass:
    43171 Da
    Quaternary structure:
    • Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3. Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAD23B Gene

    Alternative splice isoforms for RAD23B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD23B Gene

Proteomics data for RAD23B Gene at MOPED

Post-translational modifications for RAD23B Gene

  • Ubiquitination at Lys14, Lys24, Lys45, Lys51, Lys60, Lys67, Lys76, Lys147, and Lys151
  • Modification sites at PhosphoSitePlus

Other Protein References for RAD23B Gene

No data available for DME Specific Peptides for RAD23B Gene

Domains for RAD23B Gene

Suggested Antigen Peptide Sequences for RAD23B Gene

Graphical View of Domain Structure for InterPro Entry

P54727

UniProtKB/Swiss-Prot:

RD23B_HUMAN :
  • P54727
Domain:
  • The ubiquitin-like domain mediates interaction with ATXN3
  • Contains 1 STI1 domain.
  • Contains 2 UBA domains.
  • Contains 1 ubiquitin-like domain.
Family:
  • Belongs to the RAD23 family.
genes like me logo Genes that share domains with RAD23B: view

No data available for Gene Families for RAD23B Gene

Function for RAD23B Gene

Molecular function for RAD23B Gene

GENATLAS Biochemistry: yeast (S cerevisiae) RAD23 homolog B,ubiquitin conjugating enzyme E3B,58kDa,forming a tight complex with XPC
UniProtKB/Swiss-Prot Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome
UniProtKB/Swiss-Prot Function: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation
UniProtKB/Swiss-Prot Function: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5-to-3 direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5 and 3 of a cisplatin lesion with a preference for the 5 side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1

Gene Ontology (GO) - Molecular Function for RAD23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
GO:0003697 single-stranded DNA binding TAS 8168482
GO:0005515 protein binding IPI 10488153
GO:0031593 polyubiquitin binding IDA 19435460
genes like me logo Genes that share ontologies with RAD23B: view
genes like me logo Genes that share phenotypes with RAD23B: view

Animal Models for RAD23B Gene

MGI Knock Outs for RAD23B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RAD23B Gene

Localization for RAD23B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD23B Gene

Nucleus. Cytoplasm. Note=The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD23B Gene COMPARTMENTS Subcellular localization image for RAD23B gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for RAD23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus TAS 8168482
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0071942 XPC complex IDA 11279143
genes like me logo Genes that share ontologies with RAD23B: view

Pathways for RAD23B Gene

genes like me logo Genes that share pathways with RAD23B: view

Gene Ontology (GO) - Biological Process for RAD23B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000715 nucleotide-excision repair, DNA damage recognition TAS --
GO:0000718 nucleotide-excision repair, DNA damage removal TAS --
GO:0006281 DNA repair TAS --
GO:0006289 nucleotide-excision repair TAS --
GO:0006974 cellular response to DNA damage stimulus --
genes like me logo Genes that share ontologies with RAD23B: view

Compounds for RAD23B Gene

(2) Novoseek inferred chemical compound relationships for RAD23B Gene

Compound -log(P) Hits PubMed IDs
proline 25.7 1
glutamine 19.7 1
genes like me logo Genes that share compounds with RAD23B: view

Transcripts for RAD23B Gene

Unigene Clusters for RAD23B Gene

RAD23 homolog B (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD23B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
SP1: - -
SP2: -
SP3:
SP4: - - - -
SP5: - - - - - - -

Relevant External Links for RAD23B Gene

GeneLoc Exon Structure for
RAD23B
ECgene alternative splicing isoforms for
RAD23B

Expression for RAD23B Gene

mRNA expression in normal human tissues for RAD23B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD23B Gene

SOURCE GeneReport for Unigene cluster for RAD23B Gene Hs.521640

genes like me logo Genes that share expressions with RAD23B: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAD23B Gene

Orthologs for RAD23B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD23B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD23B 35
  • 99.48 (n)
  • 99.48 (a)
RAD23B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD23B 35
  • 92.48 (n)
  • 93.38 (a)
RAD23B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD23B 35
  • 91.3 (n)
  • 92.86 (a)
RAD23B 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad23b 35
  • 88.56 (n)
  • 90.93 (a)
Rad23b 16
Rad23b 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD23B 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Rad23b 35
  • 88.4 (n)
  • 91.67 (a)
chicken
(Gallus gallus)
Aves RAD23B 35
  • 78.59 (n)
  • 79.09 (a)
RAD23B 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD23B 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53561 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rad23b 35
  • 75.39 (n)
  • 78.02 (a)
Str.10080 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1739 35
zebrafish
(Danio rerio)
Actinopterygii rad23b 35
  • 68.1 (n)
  • 75.47 (a)
rad23b 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10694 36
  • 36 (a)
ManyToMany
Rad23 35
  • 51.75 (n)
  • 45.58 (a)
Rad23 36
  • 38 (a)
ManyToMany
Rad23 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea rad-23 35
  • 52.98 (n)
  • 45.14 (a)
rad-23 36
  • 38 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR358W 35
  • 44.44 (n)
  • 35.92 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD23 35
  • 47.66 (n)
  • 36.36 (a)
RAD23 36
  • 31 (a)
OneToMany
RAD23 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E22133g 35
  • 45.88 (n)
  • 33.99 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD23D 35
  • 52.55 (n)
  • 43.23 (a)
rice
(Oryza sativa)
Liliopsida Os08g0430200 35
  • 50.82 (n)
  • 40.16 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07542 35
  • 50.91 (n)
  • 48.14 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp23 35
  • 53.59 (n)
  • 46.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1944 36
  • 47 (a)
OneToMany
Species with no ortholog for RAD23B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAD23B Gene

ENSEMBL:
Gene Tree for RAD23B (if available)
TreeFam:
Gene Tree for RAD23B (if available)

Paralogs for RAD23B Gene

Paralogs for RAD23B Gene

Selected SIMAP similar genes for RAD23B Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for RAD23B Gene

genes like me logo Genes that share paralogs with RAD23B: view

Variants for RAD23B Gene

Sequence variations from dbSNP and Humsavar for RAD23B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs10868 -- 107,330,575(+) CAAGT(C/T)GTGAG utr-variant-3-prime
rs14705 -- 107,332,086(-) AAAAA(G/T)TTGAC utr-variant-3-prime
rs817835 -- 107,324,508(+) AAATA(C/T)ATGCA intron-variant
rs942292 -- 107,313,751(+) TCAAA(C/T)TGACT intron-variant
rs942293 -- 107,313,848(+) CCAGT(A/G)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD23B Gene

Variant ID Type Subtype PubMed ID
nsv831682 CNV Gain 17160897
nsv893698 CNV Gain 21882294
nsv508560 CNV Loss 20534489
esv2669320 CNV Deletion 23128226
nsv519266 CNV Gain 19592680
esv2738896 CNV Deletion 23290073
esv2738897 CNV Deletion 23290073

Relevant External Links for RAD23B Gene

HapMap Linkage Disequilibrium report
RAD23B
Human Gene Mutation Database (HGMD)
RAD23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD23B Gene

Disorders for RAD23B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for RAD23B Gene including...

Search for RAD23B Gene in MalaCards »

(2) University of Copenhagen DISEASES for RAD23B Gene

(1) Novoseek inferred disease relationships for RAD23B Gene

Disease -log(P) Hits PubMed IDs
xeroderma pigmentosum 84.1 8

Relevant External Links for RAD23B

Genetic Association Database (GAD)
RAD23B
Human Genome Epidemiology (HuGE) Navigator
RAD23B
genes like me logo Genes that share disorders with RAD23B: view

No data available for UniProtKB/Swiss-Prot for RAD23B Gene

Publications for RAD23B Gene

  1. Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (PMID: 7851894) van der Spek P.J. … Hagemeijer A. (Genomics 1994) 2 3 23
  2. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. (PMID: 10873465) Batty D. … Wood R.D. (J. Mol. Biol. 2000) 3 4 23
  3. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PMID: 10915768) Wang G. … Nukina N. (Hum. Mol. Genet. 2000) 3 4 23
  4. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. (PMID: 11279143) Araki M. … Hanaoka F. (J. Biol. Chem. 2001) 3 4 23
  5. Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a. (PMID: 12832454) Ryu K.-S. … Choi B.-S. (J. Biol. Chem. 2003) 3 4 23

Products for RAD23B Gene

Sources for RAD23B Gene

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