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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD23B Gene

protein-coding   GIFtS: 67
GCID: GC09P110045

RAD23 homolog B (S. cerevisiae)

(Previous name: RAD23 (S. cerevisiae) homolog B )
 Explore 36 diseases affiliated with
RAD23B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD23B    

Aliases
for RAD23B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAD23 Homolog B (S. Cerevisiae)1 2     RAD23, Yeast Homolog Of, B2
HR23B1 2 3     UV Excision Repair Protein RAD23 Homolog B2
HHR23B1 2     XP-C Repair Complementing Complex 58 KDa2
P581 2     XP-C Repair Complementing Protein2
XP-C Repair-Complementing Complex 58 KDa Protein2 3     HHR23B1 2
RAD23 (S. Cerevisiae) Homolog B1     P581 2

External Ids:    HGNC: 98131   Entrez Gene: 58872   Ensembl: ENSG000001193187   OMIM: 6000625   UniProtKB: P547273   

Export aliases for RAD23B gene to outside databases

Previous GC identifers: GC09P100840 GC09P101777 GC09P103503 GC09P105425 GC09P107125 GC09P109085 GC09P079647


Summaries
for RAD23B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD23B:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in
the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that
specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein
was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase
(MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal
ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in
the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants
encoding distinct isoforms. (provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: RD23B_HUMAN, P54727
Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin
chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to
deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation
(ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome
Function: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex.
Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation
Function: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with
other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition)
complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such
as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding
appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with
unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent
scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine
dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of
structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the
XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it
preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and
structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for
the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG
and SMUG1

Gene Wiki entry for RAD23B


Genomic Views
for RAD23B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD23B gene promoter:
         Bach1   AML1a   p53   CBF-C   Pax-3   CBF-B   HOXA5   c-Myb   CP1C   CP1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD23B promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD23B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD23B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q31.2   Ensembl cytogenetic band:  9q31.2   HGNC cytogenetic band: 9q31.2

RAD23B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD23B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P110045:  view genomic region     (about GC identifiers)

Start:
 110,045,418 bp from pter      End:
 110,094,475 bp from pter
Size:
 49,058 bases      Orientation:
 plus strand

Proteins
for RAD23B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RD23B_HUMAN, P54727 (See protein sequence)
Recommended Name: UV excision repair protein RAD23 homolog B  
Size: 409 amino acids; 43171 Da
Subunit: Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with
ATXN3. Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and
mediated by NGLY1 (By similarity)
Subcellular location: Nucleus. Cytoplasm. Note=The intracellular distribution is cell cycle dependent. Localized to the
nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes
in the cytoplasm without association with chromatin
3 PDB 3D structures from and Proteopedia for RAD23B:
1P1A (3D)        1PVE (3D)        1UEL (3D)    
Secondary accessions: B3KWK8 G5E9P0 Q7Z5K8 Q8WUB0
Alternative splicing: 2 isoforms:  P54727-1   P54727-2   (Highly expressed in the testis and in ejaculated spermatozoa)

Explore the universe of human proteins at neXtProt for RAD23B: NX_P54727

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54727

    • RAD23B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001231642.1  NP_001231653.1  NP_002865.1  

    ENSEMBL proteins: 
     ENSP00000416868   ENSP00000350708   ENSP00000415821   ENSP00000396975   ENSP00000405623  
    Reactome Protein details: P54727
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for RAD23B
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: RAD23B
    OriGene Custom Protein Services for RAD23B 
    GenScript Custom Purified and Recombinant Proteins Services for RAD23B
    Novus Biologicals RAD23B Proteins
    Novus Biologicals RAD23B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAD23B

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--


    RAD23B for ontologies           About GeneDecksing



    RAD23B Antibody Products: 
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    Uscn Antibodies for RAD23B
    ThermoFisher Antibodies for RAD23B

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    Uscn ELISAs and CLIAs for RAD23B

    Protein Domains /
    Families
    for RAD23B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD23B for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR004806 Rad23
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup
     IPR009060 UBA-like
     IPR006636 STI1_HS-bd

    Graphical View of Domain Structure for InterPro Entry P54727

    ProtoNet protein and cluster: P54727

    3 Blocks protein families:
    IPB000449 Ubiquitin-associated domain
    IPB000626 Ubiquitin domain
    IPB006636 Heat shock chaperonin-binding


    UniProtKB/Swiss-Prot: RD23B_HUMAN, P54727
    Domain: The ubiquitin-like domain mediates interaction with ATXN3
    Similarity: Belongs to the RAD23 family
    Similarity: Contains 1 STI1 domain
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 ubiquitin-like domain


    Function
    for RAD23B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RD23B_HUMAN, P54727
    Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin
    chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to
    deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation
    (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome
    Function: Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex.
    Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation
    Function: The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with
    other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition)
    complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such
    as single-stranded loops, mismatched bubbles or single stranded overhangs. The orientation of XPC complex binding
    appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with
    unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent
    scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine
    dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of
    structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the
    XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it
    preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and
    structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for
    the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG
    and SMUG1

         Genatlas biochemistry entry for RAD23B:
    yeast (S cerevisiae) RAD23 homolog B,ubiquitin conjugating enzyme E3B,58kDa,forming a tight complex with XPC

    miRNA
    Products:            		miRTarBase miRNAs that target RAD23B:
    hsa-mir-373 (MIRT000056), hsa-mir-30a (MIRT005172)

    OriGene 3'-UTR Clone: RAD23B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD23B
    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD23B (see all 140):
    hsa-miR-361-5p hsa-miR-106a hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-509-3-5p hsa-miR-520b hsa-miR-130a* hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: RAD23B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD23B (see all 7)
    OriGene shRNA RFP: RAD23B
    OriGene siRNA: RAD23B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD23B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for RAD23B

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD23B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD23B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAD23B (NM_002874)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD23B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD23B 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for RAD23B
    Search LifeMap BioReagents cell lines for RAD23B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD23B

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0003697single-stranded DNA binding TAS8168482
    GO:0005515protein binding IPI--
    GO:0031593polyubiquitin binding IDA19435460


    RAD23B for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for RAD23B:
     Decreased viability with pacli  Increased HDAC inhibitor resis  Increased cell death HMECs cel  Synthetic lethal with Ras 
     Upregulation of Wnt/beta-caten 

    Animal Models:
         Mouse knock-out Rad23btm1Gvh for RAD23B
         15/16 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Rad23b) (see all 16):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  craniofacial 
     digestive/alimentary  embryogenesis  endocrine/exocrine gland  growth/size  homeostasis/metabolism 
     immune system  integument  mortality/aging  normal  reproductive system 

    RAD23B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD23B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Global Genomic NER (GG-NER)
    		Global Genomic NER (GG-NER)1.00
    		Formation of incision complex in GG-NER0.61
    		Nucleotide excision repair0.70
    		Nucleotide Excision Repair Pathway0.49
    		Dual incision reaction in GG-NER0.61
    2Nucleotide Excision Repair
    		Nucleotide Excision Repair1.00
    		DNA Repair0.46
    3DNA Damage Recognition in GG-NER
    		DNA Damage Recognition in GG-NER1.00
    4Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    5Chks in Checkpoint Regulation
    		DNA Repair Mechanisms0.32

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for RAD23B
        DNA Repair Mechanisms
    Nucleotide Excision Repair Pathway

    5/6        Reactome Pathways for RAD23B (see all 6)
        DNA Repair
    DNA Damage Recognition in GG-NER
    Global Genomic NER (GG-NER)
    Nucleotide Excision Repair
    Formation of incision complex in GG-NER


    2         Kegg Pathways  (Kegg details for RAD23B):
        Nucleotide excision repair
    Protein processing in endoplasmic reticulum


    RAD23B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD23B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/195 Interacting proteins for RAD23B (P547271, 2, 3 ENSP000003507084) via UniProtKB, MINT, STRING, and/or I2D (see all 195)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD4P550361, 2, 3, ENSP000003578794EBI-954531,EBI-359318 MINT-7307775 MINT-7307859 MINT-7311293 MINT-3373412 MINT-7311345 MINT-7307505 MINT-7311314 I2D: score=15 STRING: ENSP00000357879
    ATXN3P542522, 3, ENSP000003523244MINT-2790957 MINT-2862523 I2D: score=4 STRING: ENSP00000352324
    ADRM1Q161862, 3, ENSP000002530034MINT-7308221 MINT-7308848 I2D: score=2 STRING: ENSP00000253003
    USP5P459742, 3, ENSP000002292684MINT-2791131 MINT-2791444 I2D: score=1 STRING: ENSP00000229268
    VIMP086702, 3, ENSP000002242374MINT-2791154 MINT-2791422 I2D: score=1 STRING: ENSP00000224237
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000715nucleotide-excision repair, DNA damage recognition TAS--
    GO:0000718nucleotide-excision repair, DNA damage removal TAS--
    GO:0006281DNA repair TAS--
    GO:0006289nucleotide-excision repair TAS--
    GO:0006974response to DNA damage stimulus ----


    RAD23B for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD23B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD23B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD23B
    2 Novoseek chemical compound relationships for RAD23B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 25.7 1 16712842 (1)
    glutamine 19.7 1 16860562 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD23B / RD23B 

    Transcripts
    for RAD23B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD23B gene (3 alternative transcripts): 
    NM_001244713.1  NM_001244724.1  NM_002874.4  

    Unigene Cluster for RAD23B:

    RAD23 homolog B (S. cerevisiae)
    Hs.521640  [show with all ESTs]
    Unigene Representative Sequence: NM_002874
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000419616 ENST00000358015(uc011lwa.2 uc004bde.3 uc022blj.1 uc011lwb.2)
    ENST00000442587 ENST00000457811 ENST00000416373

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD23B
    8/140 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD23B (see all 140):
    hsa-miR-361-5p hsa-miR-106a hsa-miR-3074-3p hsa-miR-342-3p hsa-miR-509-3-5p hsa-miR-520b hsa-miR-130a* hsa-miR-23c
    SwitchGear 3'UTR luciferase reporter plasmid: RAD23B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD23B (see all 7)
    OriGene shRNA RFP: RAD23B
    OriGene siRNA: RAD23B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD23B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for RAD23B (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for RAD23B
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: RAD23B (NM_002874)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD23B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD23B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for RAD23B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat RAD23B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat RAD23B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD23B

    Additional cDNA sequence: 

    AK125226.1 AK223479.1 AK297986.1 AK316189.1 AY313777.1 BC015805.1 BC020973.2 D21090.1 

    24/29 DOTS entries (see all 29):

    DT.99954880  DT.219196  DT.101984640  DT.95205412  DT.450539  DT.95250861  DT.121174023  DT.100029767 
    DT.100009655  DT.95205414  DT.435114  DT.91771796  DT.121174007  DT.95205417  DT.120912712  DT.75100900 
    DT.91701915  DT.92408727  DT.95255878  DT.100733044  DT.100795713  DT.121173970  DT.121631023  DT.91795561 

    24/534 AceView cDNA sequences (see all 534):

    CR592064 AI538438 CR622837 AI285544 T94402 BM758143 AI383110 AA442401 
    CA447020 AL119925 BQ189387 AW132114 BE676865 AI651048 BQ006361 AW614946 
    BQ188236 N36434 BG678535 C04572 AI142940 T92884 CR606267 BM705797 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for RAD23B    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
    SP1:        -     -                                                                                                         
    SP2:              -                                                                                                         
    SP3:                                                                                                                        
    SP4:                                                                    -     -     -     -                                 
    SP5:                                                                          -     -     -     -     -     -     -         


    ECgene alternative splicing isoforms for RAD23B

    Expression
    for RAD23B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD23B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTTGAGAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    RAD23B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See RAD23B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD23B

    SOURCE GeneReport for Unigene cluster: Hs.521640
        SABiosciences Expression via Pathway-Focused PCR Array including RAD23B: 
              DNA Repair in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for RAD23B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD23B gene from 9/34 species (see all 34)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves RAD23B1 RAD23 homolog B (S. cerevisiae) 79.97(n)
    80.05(a)    		   431623  XM_429175.3  XP_429175.3 
    lizard
    (Anolis carolinensis)    		 Reptilia RAD23B6
    		 --
    		 82(a)
    		 1 ↔ 1
    		 GL343218.1(2263018-2305363)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC535612 similar to RAD23 homolog B (S. cerevisiae) 82.22(n)    BC044089.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rad23b1 RAD23 homolog B (S. cerevisiae) 68(n)
    75.47(a)    		   393536  NM_200564.1  NP_956858.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rad233 nucleotide-excision repair damaged DNA
    binding    		 36(a)   102B5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea rad-236
    		 RADiation sensitivity abnormal/yeast RAD-related f...
    		 39(a)
    		 possible ortholog
    		 II(11651196-11652842)
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes RAD23(YEL037C)4
    RAD231    		 Protein with ubiquitin-like N terminus, subunit of more4
    Rad23p1    		 48.38(n)1
    38.16(a)1    		   5(82603-81407)4
    8566741, 4  NP_010877.31  NP_010877.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RAD23A1 putative DNA repair protein RAD23-2 51.62(n)
    44.57(a)    		   838188  NM_101486.2  NP_173070.1 
    rice
    (Oryza sativa)    		 Liliopsida Os02g01793001 hypothetical protein 50.61(n)
    41.97(a)    		   4328500  NM_001052618.1  NP_001046083.1 


    ENSEMBL Gene Tree for RAD23B (if available)
    TreeFam Gene Tree for RAD23B (if available) 

    Paralogs
    for RAD23B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD23B gene
    RAD23A2  
    2 SIMAP similar genes for RAD23B using alignment to 5 protein entries:     RD23B_HUMAN (see all proteins):
    RAD23A    NEDD8

    RAD23B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for RAD23B
    PGOHUM00000259845 PGOHUM00000260370


    Genomic Variants
    for RAD23B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1092 NCBI SNPs in RAD23B are shown (see all 1092)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1835729231,2
    		--110043592(+) AGCTAA/CGGGGA 1 -- us2k10--------
    rs776914761,2
    		F,--110043711(+) TGAAGG/TGAGTT 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs787794201,2
    		C,--110043891(+) AGTGGC/TCTGAC 1 -- us2k10--------
    rs1118663721,2
    		C,F,--110043938(+) GCCACA/TGGCAC 1 -- us2k13Minor allele frequency- T:0.10WA CSA 122
    rs1419019851,2
    		C,--110043955(+) AAACA-/GAGGAGAA 1 -- us2k10--------
    rs70402171,2
    		C,F,A,--110043971(+) CTGGGA/CGCGAT 1 -- us2k19Minor allele frequency- C:0.33WA NA CSA EA 369
    rs1882069311,2
    		--110044003(+) CTTTGA/GGACTC 1 -- us2k10--------
    rs802798861,2
    		F,--110044205(+) GTGCTA/CCAGCG 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1915562221,2
    		--110044273(+) AAAACA/TGGGGA 1 -- us2k10--------
    rs617013751,2
    		C,--110044372(+) CCAGGT/GGCATT 2 -- us2k14Minor allele frequency- G:0.17NA WA EA 360

    HapMap Linkage Disequilibrium report for RAD23B (110045418 - 110094475 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for RAD23B: --
    Human Gene Mutation Database (HGMD): RAD23B

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for RAD23B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD23B for disorders           About GeneDecksing

    OMIM gene information: 600062    OMIM disorders: --

    20/36 diseases for RAD23B (see all 36):    About MalaCards
    xeroderma pigmentosum, group c    xeroderma pigmentosum    machado-joseph disease    diffuse large b-cell lymphoma
    photosensitive trichthiodystrophy    b-cell lymphomas    acoustic neuroma    mutagen sensitivity
    biliary tract cancer    neuroma    breast cancer susceptibility    chronic lymphocytic leukemia
    chronic myeloid leukemia    lymphocytic leukemia    cockayne syndrome    burkitt's lymphoma
    follicular lymphoma    myeloid leukemia    multiple myeloma    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for RAD23B:
    Xeroderma pigmentosum     Cockayne syndrome

    1 Novoseek disease relationship for RAD23B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 84.1 12 12832454 (2), 16105547 (1), 9372923 (1), 10873465 (1) (see all 7)

    Genetic Association Database (GAD): RAD23B
    Human Genome Epidemiology (HuGE) Navigator: RAD23B (33 documents)

    Export disorders for RAD23B gene to outside databases

    Publications
    for RAD23B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD23B gene, integrated from 9 sources (see all 135):
    (articles sorted by number of sources associating them with RAD23B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. (PubMed id 8168482)1, 2, 3 Masutani C....Bootsma D. (1994)
    2. Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a. (PubMed id 12832454)1, 2, 9 Ryu K.-S.... Choi B.-S. (2003)
    3. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PubMed id 16712842)1, 2, 9 Chen L. and Madura K. (2006)
    4. Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B. (PubMed id 15885096)1, 2, 9 Kim B.... Choi B.-S. (2005)
    5. A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. (PubMed id 15358861)1, 2, 9 Katiyar S.... Lennarz W.J. (2004)
    6. Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B. (PubMed id 14585839)1, 2, 9 Fujiwara K.... Shirakawa M. (2004)
    7. Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (PubMed id 7851894)1, 3, 9 van der Spek P.J....Hagemeijer A. (1994)
    8. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PubMed id 10915768)1, 2, 9 Wang G....Nukina N. (2000)
    9. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. (PubMed id 10873465)1, 2, 9 Batty D....Wood R.D. (2000)
    10. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. (PubMed id 11279143)1, 2, 9 Araki M....Hanaoka F. (2001)

    External Searches for RAD23B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD23B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5887 HGNC: 9813 AceView: RAD23B Ensembl:ENSG00000119318 euGenes: HUgn5887
    ECgene: RAD23B Kegg: 5887 H-InvDB: RAD23B

    Other Databases showing RAD23B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD23B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD23B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD23B Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad23b/

    Intellectual Property
    for RAD23B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD23B gene:
    Search GeneIP for patents involving RAD23B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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