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RAD23A Gene

protein-coding   GIFtS: 66
GCID: GC19P013056

RAD23 Homolog A (S. Cerevisiae)

(Previous name: RAD23 (S. cerevisiae) homolog A)
  See RAD23A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
RAD23 Homolog A (S. Cerevisiae)1 2     RAD23 (S. Cerevisiae) Homolog A1
HR23A2 3     Yeast Homolog1
HHR23A2 5     RAD23, Yeast Homolog, A2
A1     UV Excision Repair Protein RAD23 Homolog A2
RAD231     hHR23A3

External Ids:    HGNC: 98121   Entrez Gene: 58862   Ensembl: ENSG000001792627   OMIM: 6000615   UniProtKB: P547253   

Export aliases for RAD23A gene to outside databases

Previous GC identifers: GC19P013188 GC19M013321 GC19P012901 GC19P012917 GC19P012628


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for RAD23A Gene:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein
involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an
ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein
encoded by this gene plays an important role in nucleotide excision repair and also in delivery of
polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants
encoding multiple isoforms. (provided by RefSeq, Jun 2012)

GeneCards Summary for RAD23A Gene:
RAD23A (RAD23 homolog A (S. cerevisiae)) is a protein-coding gene. Diseases associated with RAD23A include xeroderma pigmentosum, group c. GO annotations related to this gene include single-stranded DNA binding and polyubiquitin binding. An important paralog of this gene is RAD23B.

UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725
Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to
'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked
polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to
polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome
Function: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global
genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER
activity. Can stabilize XPC
Function: Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages.
Required for the association of HIV-1 vpr with the host proteasome

Gene Wiki entry for RAD23A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the RAD23A gene promoter:
         p53   ATF-2   CUTL1   Nkx2-5   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD23A promoter sequence
   Search Chromatin IP Primers for RAD23A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat RAD23A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RAD23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD23A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013056:  view genomic region     (about GC identifiers)

Start:
13,056,654 bp from pter      End:
13,064,456 bp from pter
Size:
7,803 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725 (See protein sequence)
Recommended Name: UV excision repair protein RAD23 homolog A  
Size: 363 amino acids; 39609 Da
Subunit: Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC
complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2
Sequence caution: Sequence=BX448989; Type=Frameshift; Positions=159, 333, 339, 347;
Selected PDB 3D structures from and Proteopedia for RAD23A (see all 10):
1DV0 (3D)        1F4I (3D)        1IFY (3D)        1OQY (3D)        1P98 (3D)        1P9D (3D)    
Secondary accessions: K7ESE3
Alternative splicing: 2 isoforms:  P54725-1   P54725-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for RAD23A: NX_P54725

Explore proteomics data for RAD23A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys16, Lys26, Lys47, Lys53, Lys69, Lys78, Lys80, Lys122
  • Modification sites at PhosphoSitePlus

  • See RAD23A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257291.1  NP_001257292.1  NP_005044.1  

    ENSEMBL proteins: 
     ENSP00000466243   ENSP00000321365   ENSP00000467024   ENSP00000468674   ENSP00000466968  
     ENSP00000466226   ENSP00000467628   ENSP00000438741  

    RAD23A Human Recombinant Protein Products:

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    OriGene Purified Protein for RAD23A
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    Novus Biologicals RAD23A Proteins
    Novus Biologicals RAD23A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD23A

     
    Search eBioscience for Proteins for RAD23A 

    RAD23A Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for RAD23A (Rad23)
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    LSBio Antibodies in human, mouse, rat for RAD23A

    RAD23A Assay Products:

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    Cloud-Clone Corp. ELISAs for RAD23A
    Cloud-Clone Corp. CLIAs for RAD23A
    Search eBioscience for ELISAs for RAD23A 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR004806 Rad23
     IPR000626 Ubiquitin_dom
     IPR009060 UBA-like
     IPR006636 STI1_HS-bd
     IPR000449 UBA/Ts_N

    Graphical View of Domain Structure for InterPro Entry P54725

    ProtoNet protein and cluster: P54725

    3 Blocks protein domains:
    IPB000449 Ubiquitin-associated domain
    IPB000626 Ubiquitin domain
    IPB006636 Heat shock chaperonin-binding


    UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725
    Domain: The ubiquitin-like domain mediates interaction with ATXN3
    Domain: The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly
    dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or
    proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation
    Similarity: Belongs to the RAD23 family
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 ubiquitin-like domain


    Find genes that share domains with RAD23A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RD23A_HUMAN, P54725
    Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to
    'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked
    polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to
    polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome
    Function: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global
    genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER
    activity. Can stabilize XPC
    Function: Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages.
    Required for the association of HIV-1 vpr with the host proteasome

         Genatlas biochemistry entry for RAD23A:
    yeast (S cerevisiae) RAD23 homolog A,ubiquitin conjugating enzyme E3A,involved in the degradation of short-lived
    and abnormal proteins

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0003697single-stranded DNA binding TAS8168482
    GO:0005515protein binding IPI10488153
    GO:0031593polyubiquitin binding IDA12643283
         
    Find genes that share ontologies with RAD23A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for RAD23A:
     Decreased viability with pacli  Increased cell death HMECs cel  Increased cell number in G2M,  

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rad23a):
     cellular  homeostasis/metabolism  mortality/aging  normal 

    Find genes that share phenotypes with RAD23A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Rad23atm1Jhjh for RAD23A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for RAD23A
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for RAD23A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD23A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD23A

    miRNA
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    miRTarBase miRNAs that target RAD23A:
    hsa-mir-455-3p (MIRT037882), hsa-mir-324-3p (MIRT042965), hsa-mir-615-3p (MIRT040146), hsa-mir-320a (MIRT044607)

    Block miRNA regulation of human, mouse, rat RAD23A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate RAD23A (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-3184 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-423-5p hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRAD23A 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for RAD23A
    Predesigned siRNA for gene silencing in human, mouse, rat RAD23A

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for RAD23A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: RAD23A (NM_005053)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for RAD23A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD23A
    Addgene plasmids for RAD23A 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for RAD23A 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD23A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RD23A_HUMAN, P54725: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with RAD23A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for RAD23A About    
    See pathways by source

    SuperPathContained pathways About
    1Global Genomic NER (GG-NER)
    Nucleotide excision repair0.69
    2Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with RAD23A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Kegg Pathways  (Kegg details for RAD23A):
        Nucleotide excision repair
    Protein processing in endoplasmic reticulum

        Pathway & Disease-focused RT2 Profiler PCR Array including RAD23A: 
              DNA Repair in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for RAD23A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for RAD23A (P547251, 2, 3 ENSP000003213654) via UniProtKB, MINT, STRING, and/or I2D (see all 269)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000212866P081072, 3MINT-2791462 I2D: score=1 
    ENSG00000215328P081072, 3MINT-2791462 I2D: score=1 
    ENSG00000224501P081072, 3MINT-2791462 I2D: score=1 
    ENSG00000231555P081072, 3MINT-2791462 I2D: score=1 
    ENSG00000234475P081072, 3MINT-2791462 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006289nucleotide-excision repair IDA9372924
    GO:0006974cellular response to DNA damage stimulus ----
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IDA12643283

    Find genes that share ontologies with RAD23A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for RAD23A (RD23A)

    1 Novoseek inferred chemical compound relationship for RAD23A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 25.7 1 16712842 (1)



    Find genes that share compounds with RAD23A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for RAD23A gene (3 alternative transcripts): 
    NM_001270362.1  NM_001270363.1  NM_005053.3  

    Unigene Cluster for RAD23A:

    RAD23 homolog A (S. cerevisiae)
    Hs.643267  [show with all ESTs]
    Unigene Representative Sequence: NM_005053
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591499 ENST00000588329 ENST00000316856(uc002mvw.1 uc002mvz.1 uc010xmw.1)
    ENST00000586534 ENST00000592268 ENST00000593114 ENST00000588826 ENST00000586375
    ENST00000590881 ENST00000591467 ENST00000541222
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate RAD23A (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-3184 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-423-5p hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmidRAD23A 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for RAD23A 
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      QuantiTect SYBR Green Assays in human, mouse, rat RAD23A
      QuantiFast Probe-based Assays in human, mouse, rat RAD23A

    Additional mRNA sequence: 

    AB209713.1 AK289908.1 AK293219.1 BC014026.2 BC088364.1 D21235.1 M77024.1 NR_072976.1 

    Selected DOTS entries (see all 27):

    DT.450050  DT.95332741  DT.217955  DT.121481531  DT.91931761  DT.92452855  DT.95332746  DT.92452858 
    DT.97865009  DT.99987109  DT.100730108  DT.100878689  DT.100878681  DT.100878691  DT.100878695  DT.107299 
    DT.121481548  DT.121481559  DT.121481591  DT.85104197  DT.95332596  DT.100743580  DT.100876775  DT.40116232 

    Selected AceView cDNA sequences (see all 839):

    BQ220978 BP374135 F27817 BU170588 BQ431936 BF933559 CA427788 BG272372 
    F10834 W73807 BC014026 BU633839 BM543659 BQ226301 CR602320 BQ068116 
    CR615357 T80819 BM905361 AI079921 CA306455 BG282652 BU186368 CD108879 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for RAD23A (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                                                                    -                                                         
    SP2:                                                                    -                                                         
    SP3:                                      -                             -                                                         
    SP4:                                      -     -                       -                                                         
    SP5:                                      -                                                                                       


    ECgene alternative splicing isoforms for RAD23A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    RAD23A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTATTTAAG
    RAD23A Expression
    About this image


    RAD23A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Blood (Hematopoietic System)
             Erythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Liver (Hepatobiliary System)
    RAD23A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    RAD23A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643267
        Pathway & Disease-focused RT2 Profiler PCR Array including RAD23A: 
              DNA Repair in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for RAD23A
    OriGene qSTAR qPCR primer pairs in human, mouse for RAD23A
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    QuantiFast Probe-based Assays in human, mouse, rat RAD23A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD23A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD23A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad23a1 , 5 RAD23a homolog (S. cerevisiae)1, 5 89.23(n)1
    94.75(a)1
      8 (41.20 cM)5
    193581  NM_009010.41  NP_033036.21 
     848340195 
    chicken
    (Gallus gallus)
    Aves RAD23A6
    RAD23 homolog A (S. cerevisiae)
    86(a)
    1 ↔ 1
    AADN03021961.1(21-1697)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    80(a)
    57(a)
    many → 1
    many → 1
    2(77788848-77811124)
    AAWZ02040720(2541-5430)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659512 hypothetical protein MGC65951 77.66(n)   393536  BC056578.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad233 nucleotide-excision repair damaged DNA
    binding
    40(a)   102B5   --
    worm
    (Caenorhabditis elegans)
    Secernentea rad-236
    Protein RAD-23 (rad-23) mRNA, complete cds
    36(a)
    1 → many
    II(11651260-11652906) WBGene00013924
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD236
    Protein with ubiquitin-like N terminus, subunit of...
    30(a)
    1 → many
    V(81407-82603) YEL037C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons RAD23B1 RAD23B 48.62(n)
    42.98(a)
      844304  NM_001198510.1  NP_001185439.1 
    rice
    (Oryza sativa)
    Liliopsida Os02g01793001 Os02g0179300 50.15(n)
    40.12(a)
      4328500  NM_001052618.1  NP_001046083.1 


    ENSEMBL Gene Tree for RAD23A (if available)
    TreeFam Gene Tree for RAD23A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for RAD23A gene
    RAD23B2  
    8 SIMAP similar genes for RAD23A using alignment to 7 protein entries:     RD23A_HUMAN (see all proteins):
    RAD23B    UBA52    RPS27A    NEDD8-MDP1    UBB    UBC
    NEDD8    UBBP4

    Find genes that share paralogs with RAD23A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for RAD23A (see all 242)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1441115441,2
    --13056150(+) AACACG/TGTGAA 4 -- us2k10--------
    rs455405461,2
    C,F--13056213(+) TACTCG/CGGAGG 4 -- us2k13Minor allele frequency- C:0.05NS WA CSA 140
    rs454994001,2
    C,F--13056268(+) TGAGCC/TGAGAT 4 -- us2k11Minor allele frequency- T:0.01NS 136
    rs1883174191,2
    --13056292(+) TCCAGC/TCTGGG 4 -- us2k10--------
    rs1926039861,2
    --13056299(+) TGGGTA/GACAGA 4 -- us2k10--------
    rs735053801,2
    C--13056315(+) TTTGAA/GAGAAA 4 -- us2k12Minor allele frequency- G:0.11WA 120
    rs1497905481,2
    --13056377(+) TGTCTA/GTAACC 4 -- us2k10--------
    rs730046951,2
    --13056532(+) CGCCCA/GCAGCG 4 -- us2k10--------
    rs761535781,2
    F--13056542(+) GCGGAG/CTTTAG 4 -- us2k11Minor allele frequency- C:0.02WA 118
    rs455958371,2
    C,F--13056554(+) CTGCGC/GGTACC 4 -- us2k11Minor allele frequency- G:0.01NS 176

    HapMap Linkage Disequilibrium report for RAD23A (13056654 - 13064456 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for RAD23A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911085CNV Loss21882294
    nsv833754CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD23A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD23A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600061    OMIM disorders: --

    1 disease for RAD23A:    
    About MalaCards
    xeroderma pigmentosum, group c

    2 diseases from the University of Copenhagen DISEASES database for RAD23A:
    Xeroderma pigmentosum     Machado-Joseph disease

    Find genes that share disorders with RAD23A           About GenesLikeMe

    1 Novoseek inferred disease relationship for RAD23A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 71.2 4 16105547 (2), 15322280 (1), 15885096 (1)

    Genetic Association Database (GAD): RAD23A
    Human Genome Epidemiology (HuGE) Navigator: RAD23A (7 documents)

    Export disorders for RAD23A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for RAD23A gene, integrated from 10 sources (see all 123):
    (articles sorted by number of sources associating them with RAD23A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. (PubMed id 14557549)1, 2, 9 Walters K.J.... Howley P.M. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    2. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. (PubMed id 15321727)1, 2, 9 Raasi S.... Pickart C.M. (J. Mol. Biol. 2004)
    3. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PubMed id 10915768)1, 2, 9 Wang G.... Nukina N. (Hum. Mol. Genet. 2000)
    4. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PubMed id 16712842)1, 2, 9 Chen L. and Madura K. (FEBS Lett. 2006)
    5. Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (PubMed id 7851894)1, 3, 9 van der Spek P.J....Hagemeijer A. (Genomics 1994)
    6. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. (PubMed id 18234089)1, 2, 9 Goh A.M.... Howley P.M. (BMC Biochem. 2008)
    7. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. (PubMed id 9372924)1, 2, 9 Sugasawa K.... Hoeijmakers J.H. (Mol. Cell. Biol. 1997)
    8. Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PubMed id 20496165)1, 4 Monsees G.M....Han J. (Breast Cancer Res. Treat. 2011)
    9. Variation within DNA repair pathway genes and risk of multiple sclerosis. (PubMed id 20522537)1, 4 Briggs F.B....Barcellos L.F. (Am. J. Epidemiol. 2010)
    10. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. (PubMed id 20614012)1, 2 Li G.... Zhao R.Y. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5886 HGNC: 9812 AceView: RAD23A Ensembl:ENSG00000179262 euGenes: HUgn5886
    ECgene: RAD23A Kegg: 5886 H-InvDB: RAD23A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for RAD23A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD23A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad23a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for RAD23A gene:
    Search GeneIP for patents involving RAD23A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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