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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD23A Gene

protein-coding   GIFtS: 62
GCID: GC19P013056

RAD23 homolog A (S. cerevisiae)

(Previous name: RAD23 (S. cerevisiae) homolog A )
 Explore 15 diseases affiliated with
RAD23A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for RAD23A    

Aliases
for RAD23A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
RAD23 Homolog A (S. Cerevisiae)1 2     RAD23 (S. Cerevisiae) Homolog A1
HHR23A1 2 5     RAD23, Yeast Homolog, A2
HR23A2 3     UV Excision Repair Protein RAD23 Homolog A2
MGC1110831     HHR23A1 2 5

External Ids:    HGNC: 98121   Entrez Gene: 58862   Ensembl: ENSG000001792627   OMIM: 6000615   UniProtKB: P547253   

Export aliases for RAD23A gene to outside databases

Previous GC identifers: GC19P013188 GC19M013321 GC19P012901 GC19P012917 GC19P012628


Summaries
for RAD23A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for RAD23A:
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in
nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like
domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene
plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the
proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. (provided by
RefSeq, Jun 2012)

UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725
Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked
polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains.
Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver
ubiquitinated proteins to the proteasome
Function: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome
nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can
stabilize XPC
Function: Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required
for the association of HIV-1 vpr with the host proteasome

Gene Wiki entry for RAD23A


Genomic Views
for RAD23A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD23A gene promoter:
         p53   ATF-2   CUTL1   Nkx2-5   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): RAD23A promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD23A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD23A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

RAD23A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD23A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013056:  view genomic region     (about GC identifiers)

Start:
 13,056,654 bp from pter      End:
 13,064,456 bp from pter
Size:
 7,803 bases      Orientation:
 plus strand

Proteins
for RAD23A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725 (See protein sequence)
Recommended Name: UV excision repair protein RAD23 homolog A  
Size: 363 amino acids; 39609 Da
Subunit: Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC
complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3. Interacts with HIV-1 vpr. Interacts with UBQLN2
Subcellular location: Nucleus
6/10 PDB 3D structures from and Proteopedia for RAD23A (see all 10):
1DV0 (3D)        1F4I (3D)        1IFY (3D)        1OQY (3D)        1P98 (3D)        1P9D (3D)    

Explore the universe of human proteins at neXtProt for RAD23A: NX_P54725

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P54725

    • RAD23A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001257291.1  NP_001257292.1  NP_005044.1  

    ENSEMBL proteins: 
     ENSP00000466243   ENSP00000321365   ENSP00000467024   ENSP00000468674   ENSP00000466968  
     ENSP00000466226   ENSP00000467628   ENSP00000438741  

    Human Recombinant Protein Products: 
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    Novus Biologicals RAD23A Proteins
    Novus Biologicals RAD23A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for RAD23A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005634nucleus IEA--


    RAD23A for ontologies           About GeneDecksing



    RAD23A Antibody Products: 
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    Uscn ELISAs and CLIAs for RAD23A

    Protein Domains /
    Families
    for RAD23A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    RAD23A for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR004806 Rad23
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup
     IPR009060 UBA-like
     IPR006636 STI1_HS-bd

    Graphical View of Domain Structure for InterPro Entry P54725

    ProtoNet protein and cluster: P54725

    3 Blocks protein families:
    IPB000449 Ubiquitin-associated domain
    IPB000626 Ubiquitin domain
    IPB006636 Heat shock chaperonin-binding


    UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725
    Domain: The ubiquitin-like domain mediates interaction with ATXN3
    Domain: The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly
    dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome
    subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation
    Similarity: Belongs to the RAD23 family
    Similarity: Contains 2 UBA domains
    Similarity: Contains 1 ubiquitin-like domain


    Function
    for RAD23A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RD23A_HUMAN, P54725
    Function: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked
    polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains.
    Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver
    ubiquitinated proteins to the proteasome
    Function: Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome
    nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can
    stabilize XPC
    Function: Involved in vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required
    for the association of HIV-1 vpr with the host proteasome

         Genatlas biochemistry entry for RAD23A:
    yeast (S cerevisiae) RAD23 homolog A,ubiquitin conjugating enzyme E3A,involved in the degradation of short-lived and
    abnormal proteins

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD23A (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-3184 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-423-5p hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: RAD23A 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD23A (see all 7)
    OriGene shRNA RFP: RAD23A
    OriGene siRNA: RAD23A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD23A

    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat RAD23A 

    Cell Line
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    Search LifeMap BioReagents cell lines for RAD23A

    In Situ Assay
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         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAD23A

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003684damaged DNA binding IEA--
    GO:0003697single-stranded DNA binding TAS8168482
    GO:0005515protein binding IPI17098253
    GO:0031593polyubiquitin binding IDA12643283


    RAD23A for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for RAD23A:
     Decreased viability with pacli  Increased cell death HMECs cel  Increased cell number in G2M,  

    Animal Models:
         Mouse knock-out Rad23atm1Jhjh for RAD23A
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Rad23a):
     cellular  homeostasis/metabolism  mortality/aging  normal 

    RAD23A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for RAD23A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    2Global Genomic NER (GG-NER)
    		Nucleotide excision repair0.70

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for RAD23A):
        Nucleotide excision repair
    Protein processing in endoplasmic reticulum


    RAD23A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for RAD23A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/138 Interacting proteins for RAD23A (P547251, 2, 3 ENSP000003213654) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD4P550361, 2, 3, ENSP000003578794EBI-746453,EBI-359318 MINT-3373395 MINT-50291 MINT-50290 I2D: score=4 STRING: ENSP00000357879
    SQSTM1Q135011, 2, 3, ENSP000003744554EBI-746453,EBI-307104 MINT-66845 I2D: score=6 STRING: ENSP00000374455
    EEF1A1P681042, 3, ENSP000003300544MINT-2791404 MINT-2791086 I2D: score=1 STRING: ENSP00000330054
    ATXN3P542522, 3, ENSP000003523244MINT-2862451 I2D: score=4 STRING: ENSP00000352324
    ATXN7O152652, 3, ENSP000003815904MINT-2862504 I2D: score=2 STRING: ENSP00000381590
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006289nucleotide-excision repair IDA9372924
    GO:0006974response to DNA damage stimulus ----
    GO:0019048virus-host interaction IEA--
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IDA12643283
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process IEA--


    RAD23A for ontologies           About GeneDecksing



    Drugs & Compounds
    for RAD23A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD23A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD23A
    1 Novoseek chemical compound relationship for RAD23A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 25.7 1 16712842 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD23A / RD23A 

    Transcripts
    for RAD23A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for RAD23A gene (3 alternative transcripts): 
    NM_001270362.1  NM_001270363.1  NM_005053.3  

    Unigene Cluster for RAD23A:

    RAD23 homolog A (S. cerevisiae)
    Hs.643267  [show with all ESTs]
    Unigene Representative Sequence: BF343783
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000591499 ENST00000588329 ENST00000316856(uc002mvw.1 uc002mvz.1 uc010xmw.1)
    ENST00000586534 ENST00000592268 ENST00000593114 ENST00000588826 ENST00000586375
    ENST00000590881 ENST00000591467 ENST00000541222

    miRNA
    Products:             		 OriGene 3'-UTR Clone: RAD23A
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat RAD23A
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate RAD23A (see all 13):
    hsa-miR-3163 hsa-miR-361-5p hsa-miR-3184 hsa-miR-548e hsa-miR-548o hsa-miR-340 hsa-miR-423-5p hsa-miR-374a*
    SwitchGear 3'UTR luciferase reporter plasmid: RAD23A 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for RAD23A (see all 7)
    OriGene shRNA RFP: RAD23A
    OriGene siRNA: RAD23A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat RAD23A
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209713.1 AK289908.1 AK293219.1 BC014026.2 BC088364.1 D21235.1 M77024.1 NR_072976.1 

    24/28 DOTS entries (see all 28):

    DT.450050  DT.217955  DT.95332741  DT.121481531  DT.91931761  DT.92452855  DT.95332746  DT.92452858 
    DT.97865009  DT.99987109  DT.100730108  DT.100878689  DT.97759885  DT.100878681  DT.100878691  DT.100878695 
    DT.107299  DT.121481548  DT.121481559  DT.121481591  DT.85104197  DT.95332596  DT.100743580  DT.100876775 

    24/839 AceView cDNA sequences (see all 839):

    BU182138 AI867063 BU501586 AI378277 BM805413 BM923938 AJ572447 CD619707 
    BM479713 BE743148 AI278573 BM704211 BM849173 CD108879 BE646240 BU186368 
    BG282652 CA306455 BM905361 T80819 AI079921 CR615357 CR602320 BQ226301 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for RAD23A (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:                                                                    -                                                         
    SP2:                                                                    -                                                         
    SP3:                                      -                             -                                                         
    SP4:                                      -     -                       -                                                         
    SP5:                                      -                                                                                       


    ECgene alternative splicing isoforms for RAD23A

    Expression
    for RAD23A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD23A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTATTTAAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See RAD23A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD23A

    SOURCE GeneReport for Unigene cluster: Hs.643267
        SABiosciences Expression via Pathway-Focused PCR Array including RAD23A: 
              DNA Repair in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat RAD23A
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for RAD23A

    Orthologs
    for RAD23A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for RAD23A gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Rad23a1 , 5 RAD23a homolog (S. cerevisiae)1, 5 89.23(n)1
    94.75(a)1    		   8 (41.20 cM)5
    193581  NM_009010.41  NP_033036.21 
     848340195 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 81(a)
    69(a)
    		 many → 1
    many → 1
    		 2(77788848-77806285)
    AAWZ02040720(2636-5242)
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659512 hypothetical protein MGC65951 77.66(n)   393536  BC056578.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Rad231 , 3 nucleotide-excision repair damaged DNA
    binding3
    CG1836-PA1    		 40(a)3
    49.2(n)1
    47.59(a)1    		   102B53
    437851  NM_143661.21  NP_651918.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea rad-231 Protein RAD-23 52.23(n)
    43.31(a)    		   174785  NM_064087.5  NP_496488.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons RAD23C1 putative DNA repair protein RAD23-3 52.03(n)
    44.19(a)    		   821195  NM_111121.3  NP_186903.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g02643001 hypothetical protein 49(n)
    39.32(a)    		   4340699  NM_001063869.1  NP_001057334.1 


    ENSEMBL Gene Tree for RAD23A (if available)
    TreeFam Gene Tree for RAD23A (if available) 

    Paralogs
    for RAD23A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD23A gene
    RAD23B2  
    7 SIMAP similar genes for RAD23A using alignment to 8 protein entries:     RD23A_HUMAN (see all proteins):
    RAD23B    RPS27A    UBC    NEDD8-MDP1    UBB    NEDD8
    UBBP4

    RAD23A for paralogs           About GeneDecksing



    Genomic Variants
    for RAD23A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 NCBI SNPs in RAD23A are shown (see all 193)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1441115441,2
    		--13056150(+) AACACG/TGTGAA 4 -- us2k10--------
    rs455405461,2
    		C,F,--13056213(+) TACTCG/CGGAGG 4 -- us2k13Minor allele frequency- C:0.05NS WA CSA 140
    rs454994001,2
    		C,--13056268(+) TGAGCC/TGAGAT 4 -- us2k11Minor allele frequency- T:0.01NS 136
    rs1883174191,2
    		--13056292(+) TCCAGC/TCTGGG 4 -- us2k10--------
    rs1926039861,2
    		--13056299(+) TGGGTA/GACAGA 4 -- us2k10--------
    rs735053801,2
    		C,--13056315(+) TTTGAA/GAGAAA 4 -- us2k12Minor allele frequency- G:0.11WA 120
    rs1497905481,2
    		--13056377(+) TGTCTA/GTAACC 4 -- us2k10--------
    rs730046951,2
    		--13056532(+) CGCCCA/GCAGCG 4 -- us2k10--------
    rs761535781,2
    		F,--13056542(+) GCGGAG/CTTTAG 4 -- us2k11Minor allele frequency- C:0.02WA 118
    rs455958371,2
    		C,F,--13056554(+) CTGCGC/GGTACC 4 -- us2k11Minor allele frequency- G:0.01NS 176

    HapMap Linkage Disequilibrium report for RAD23A (13056654 - 13064456 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for RAD23A
         1 CNV: 4400

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing RAD23A
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD23A

    Disorders / Diseases
    for RAD23A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    RAD23A for disorders           About GeneDecksing

    OMIM gene information: 600061    OMIM disorders: --

    15 diseases for RAD23A:    About MalaCards
    xeroderma pigmentosum, group c    xeroderma pigmentosum    paget's disease of bone    rheumatic fever
    fanconi's anemia    multiple sclerosis    hermaphroditism    anemia
    breast cancer    ataxia    immunodeficiency    melanoma
    malaria    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for RAD23A:
    Xeroderma pigmentosum

    1 Novoseek disease relationship for RAD23A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    xeroderma pigmentosum 71.2 4 16105547 (2), 15322280 (1), 15885096 (1)

    Human Genome Epidemiology (HuGE) Navigator: RAD23A (7 documents)

    Export disorders for RAD23A gene to outside databases

    Publications
    for RAD23A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD23A gene, integrated from 9 sources (see all 112):
    (articles sorted by number of sources associating them with RAD23A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. (PubMed id 14557549)1, 2, 9 Walters K.J....Howley P.M. (2003)
    2. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. (PubMed id 15321727)1, 2, 9 Raasi S....Pickart C.M. (2004)
    3. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PubMed id 10915768)1, 2, 9 Wang G....Nukina N. (2000)
    4. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PubMed id 16712842)1, 2, 9 Chen L. and Madura K. (2006)
    5. Chromosomal localization of three repair genes: the xeroderma pigmentosum group C gene and two human homologs of yeast RAD23. (PubMed id 7851894)1, 3, 9 van der Spek P.J....Hagemeijer A. (1994)
    6. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. (PubMed id 18234089)1, 2, 9 Goh A.M....Howley P.M. (2008)
    7. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity. (PubMed id 9372924)1, 2, 9 Sugasawa K....Hoeijmakers J.H. (1997)
    8. HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome. (PubMed id 20614012)1, 2 Li G....Zhao R.Y. (2010)
    9. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    10. Ubiquitin receptor proteins hHR23a and hPLIC2 interact. (PubMed id 17098253)1, 2 Kang Y....Walters K.J. (2007)

    External Searches for RAD23A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing RAD23A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5886 HGNC: 9812 AceView: RAD23A Ensembl:ENSG00000179262 euGenes: HUgn5886
    ECgene: RAD23A Kegg: 5886 H-InvDB: RAD23A

    Other Databases showing RAD23A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing RAD23A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD23A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD23A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad23a/

    Intellectual Property
    for RAD23A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for RAD23A gene:
    Search GeneIP for patents involving RAD23A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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