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Aliases for RAD21L1 Gene

Aliases for RAD21L1 Gene

  • RAD21 Cohesin Complex Component Like 1 2 3 5
  • RAD21L 3 4
  • Double-Strand-Break Repair Protein Rad21-Like Protein 1 3
  • RAD21-Like 1 (S. Pombe) 2
  • RAD21-Like 1 3
  • DJ545L17.2 3

External Ids for RAD21L1 Gene

Previous GeneCards Identifiers for RAD21L1 Gene

  • GC20U990229
  • GC20P001166

Summaries for RAD21L1 Gene

GeneCards Summary for RAD21L1 Gene

RAD21L1 (RAD21 Cohesin Complex Component Like 1) is a Protein Coding gene. An important paralog of this gene is RAD21.

UniProtKB/Swiss-Prot for RAD21L1 Gene

  • Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

Additional gene information for RAD21L1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD21L1 Gene

Genomics for RAD21L1 Gene

Regulatory Elements for RAD21L1 Gene

Enhancers for RAD21L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H001286 0.9 FANTOM5 ENCODE dbSUPER 11.4 +60.9 60945 0 ZIC2 SNPH RAD21L1 SDCBP2 FKBP1A SIRPD ENSG00000242324 SIRPG PIR62557 ENSG00000280162
GH20H001279 0.5 dbSUPER 11.2 +54.7 54684 2 FOXA2 MAFK FOXA1 EGR2 RAD21L1 SDCBP2 FKBP1A PIR62557 ENSG00000280162
GH20H001278 0.5 FANTOM5 dbSUPER 11.2 +52.5 52525 0 RAD21L1 SDCBP2 FKBP1A TMEM74B C20orf202 PIR62557 ENSG00000280162
GH20H001276 0.3 FANTOM5 10.8 +50.1 50075 0 RAD21L1 SDCBP2 ENSG00000229728 TMEM74B PIR62557 ENSG00000280162
GH20H001225 0.9 ENCODE 0.7 -0.1 -121 1 TBP INSM2 ZNF76 KLF17 SIN3A GLIS2 ZNF391 EGR2 SP3 SMAD5 TBC1D20 RBCK1 ENSG00000229728 ACTG1P3 RAD21L1 C20orf202
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RAD21L1 on UCSC Golden Path with GeneCards custom track

Promoters for RAD21L1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133511 58 1799 SIN3A GLIS2 SP3 REST NFIL3 AEBP2 MXD3 RCOR2 KDM1A WT1

Genomic Location for RAD21L1 Gene

Chromosome:
20
Start:
1,226,043 bp from pter
End:
1,296,421 bp from pter
Size:
70,379 bases
Orientation:
Plus strand

Genomic View for RAD21L1 Gene

Genes around RAD21L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD21L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD21L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD21L1 Gene

Proteins for RAD21L1 Gene

  • Protein details for RAD21L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4I0-RD21L_HUMAN
    Recommended name:
    Double-strand-break repair protein rad21-like protein 1
    Protein Accession:
    Q9H4I0
    Secondary Accessions:
    • B2RXL0
    • B7ZBB1
    • B7ZW76
    • Q5W0X5

    Protein attributes for RAD21L1 Gene

    Size:
    556 amino acids
    Molecular mass:
    63324 Da
    Quaternary structure:
    • Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3.

    Alternative splice isoforms for RAD21L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD21L1 Gene

Post-translational modifications for RAD21L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAD21L1 Gene

Domains & Families for RAD21L1 Gene

Gene Families for RAD21L1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAD21L1 Gene

Suggested Antigen Peptide Sequences for RAD21L1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H4I0

UniProtKB/Swiss-Prot:

RD21L_HUMAN :
  • Belongs to the rad21 family.
Family:
  • Belongs to the rad21 family.
genes like me logo Genes that share domains with RAD21L1: view

Function for RAD21L1 Gene

Molecular function for RAD21L1 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

Phenotypes From GWAS Catalog for RAD21L1 Gene

Gene Ontology (GO) - Molecular Function for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IBA --
genes like me logo Genes that share ontologies with RAD21L1: view
genes like me logo Genes that share phenotypes with RAD21L1: view

Animal Models for RAD21L1 Gene

MGI Knock Outs for RAD21L1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAD21L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RAD21L1 Gene

Localization for RAD21L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD21L1 Gene

Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. {ECO:0000250 UniProtKB:A2AU37}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD21L1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0000798 nuclear cohesin complex IBA --
GO:0000800 lateral element IEA --
GO:0005634 nucleus ISS --
GO:0005694 chromosome ISS --
genes like me logo Genes that share ontologies with RAD21L1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAD21L1 Gene

Pathways & Interactions for RAD21L1 Gene

SuperPathways for RAD21L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0006302 double-strand break repair IEA,IBA --
GO:0007059 chromosome segregation IEA --
GO:0007062 sister chromatid cohesion IBA --
GO:0007129 synapsis IEA --
genes like me logo Genes that share ontologies with RAD21L1: view

No data available for Pathways by source and SIGNOR curated interactions for RAD21L1 Gene

Drugs & Compounds for RAD21L1 Gene

No Compound Related Data Available

Transcripts for RAD21L1 Gene

mRNA/cDNA for RAD21L1 Gene

(8) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAD21L1 Gene

RAD21-like 1 (S. pombe):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RAD21L1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RAD21L1 Gene

No ASD Table

Relevant External Links for RAD21L1 Gene

GeneLoc Exon Structure for
RAD21L1
ECgene alternative splicing isoforms for
RAD21L1

Expression for RAD21L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD21L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD21L1 Gene

This gene is overexpressed in Testis (x46.1).

NURSA nuclear receptor signaling pathways regulating expression of RAD21L1 Gene:

RAD21L1

SOURCE GeneReport for Unigene cluster for RAD21L1 Gene:

Hs.713451
genes like me logo Genes that share expression patterns with RAD21L1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD21L1 Gene

Orthologs for RAD21L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD21L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD21L1 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia RAD21L1 33 34
  • 90.09 (n)
dog
(Canis familiaris)
Mammalia RAD21L1 34 33
  • 90.03 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rad21l 33 16 34
  • 84.12 (n)
rat
(Rattus norvegicus)
Mammalia Rad21l1 33
  • 82.25 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD21L1 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD21L1 34
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD21L1 33 34
  • 62.75 (n)
lizard
(Anolis carolinensis)
Reptilia RAD21L1 34
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rad21l1 34
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vtd 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea coh-1 33 34
  • 49.27 (n)
scc-1 34
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCD1 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for RAD21L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAD21L1 Gene

ENSEMBL:
Gene Tree for RAD21L1 (if available)
TreeFam:
Gene Tree for RAD21L1 (if available)

Paralogs for RAD21L1 Gene

Paralogs for RAD21L1 Gene

(2) SIMAP similar genes for RAD21L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAD21L1: view

Variants for RAD21L1 Gene

Sequence variations from dbSNP and Humsavar for RAD21L1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000143266 -- 1,242,572(+) GATTT(C/T)AGAAA intron-variant
rs1000155681 -- 1,235,329(+) TCCTT(A/G)CTCTG intron-variant
rs1000168816 -- 1,256,359(+) CACCC(A/G)GCTTA downstream-variant-500B
rs1000209229 -- 1,240,764(+) TTTCC(A/G)TGGTG intron-variant
rs1000272162 -- 1,235,472(+) AAATT(A/T)AAAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD21L1 Gene

Variant ID Type Subtype PubMed ID
dgv7425n54 CNV loss 21841781
nsv1057097 CNV gain 25217958
nsv516776 CNV loss 19592680
nsv518957 CNV gain 19592680

Variation tolerance for RAD21L1 Gene

Gene Damage Index Score: 13.31; 95.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RAD21L1 Gene

Human Gene Mutation Database (HGMD)
RAD21L1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD21L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD21L1 Gene

Disorders for RAD21L1 Gene

Relevant External Links for RAD21L1

Genetic Association Database (GAD)
RAD21L1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RAD21L1

No disorders were found for RAD21L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAD21L1 Gene

Publications for RAD21L1 Gene

  1. Identification and molecular characterization of the mammalian α-kleisin RAD21L. (PMID: 21527826) Gutiérrez-Caballero C … Pendás AM (Cell cycle (Georgetown, Tex.) 2011) 2 3 60
  2. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 3 45 60
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 60
  4. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 60
  5. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L … Wang L (BMC genomics 2014) 3 60

Products for RAD21L1 Gene

Sources for RAD21L1 Gene

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