Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAD21L1 Gene

Aliases for RAD21L1 Gene

  • RAD21-Like 1 (S. Pombe) 2 3
  • RAD21L 3 4
  • Double-Strand-Break Repair Protein Rad21-Like Protein 1 3
  • DJ545L17.2 3

External Ids for RAD21L1 Gene

Summaries for RAD21L1 Gene

GeneCards Summary for RAD21L1 Gene

RAD21L1 (RAD21-Like 1 (S. Pombe)) is a Protein Coding gene. An important paralog of this gene is RAD21.

UniProtKB/Swiss-Prot for RAD21L1 Gene

  • Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD21L1 Gene

Genomics for RAD21L1 Gene

Genomic Location for RAD21L1 Gene

Start:
1,226,056 bp from pter
End:
1,296,421 bp from pter
Size:
70,366 bases
Orientation:
Plus strand

Genomic View for RAD21L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD21L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD21L1 Gene

Regulatory Elements for RAD21L1 Gene

Proteins for RAD21L1 Gene

  • Protein details for RAD21L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H4I0-RD21L_HUMAN
    Recommended name:
    Double-strand-break repair protein rad21-like protein 1
    Protein Accession:
    Q9H4I0
    Secondary Accessions:
    • B2RXL0
    • B7ZBB1
    • B7ZW76
    • Q5W0X5

    Protein attributes for RAD21L1 Gene

    Size:
    556 amino acids
    Molecular mass:
    63324 Da
    Quaternary structure:
    • Component of some meiotic cohesin complex composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21L which link them, and STAG3.

    Alternative splice isoforms for RAD21L1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD21L1 Gene

Proteomics data for RAD21L1 Gene at MOPED

Post-translational modifications for RAD21L1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys521

Other Protein References for RAD21L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAD21L1 Gene

Domains for RAD21L1 Gene

Protein Domains for RAD21L1 Gene

UniProtKB/Swiss-Prot:

RD21L_HUMAN
Family:
  • Belongs to the rad21 family.:
    • Q9H4I0
genes like me logo Genes that share domains with RAD21L1: view

No data available for Gene Families for RAD21L1 Gene

Function for RAD21L1 Gene

Molecular function for RAD21L1 Gene

UniProtKB/Swiss-Prot Function: Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

Gene Ontology (GO) - Molecular Function for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with RAD21L1: view
genes like me logo Genes that share phenotypes with RAD21L1: view

Animal Models for RAD21L1 Gene

MGI Knock Outs for RAD21L1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RAD21L1 Gene

Localization for RAD21L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD21L1 Gene

Nucleus. Chromosome. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD21L1 Gene COMPARTMENTS Subcellular localization image for RAD21L1 gene
Compartment Confidence
nucleus 4
cytosol 2
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome --
GO:0000800 lateral element IEA --
GO:0005634 nucleus ISS --
GO:0005694 chromosome ISS --
GO:0030893 meiotic cohesin complex ISS --
genes like me logo Genes that share ontologies with RAD21L1: view

Pathways for RAD21L1 Gene

SuperPathways for RAD21L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RAD21L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000724 double-strand break repair via homologous recombination IEA --
GO:0006302 double-strand break repair --
GO:0007059 chromosome segregation --
GO:0007129 synapsis --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with RAD21L1: view

No data available for Pathways by source for RAD21L1 Gene

Transcripts for RAD21L1 Gene

mRNA/cDNA for RAD21L1 Gene

(9) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAD21L1 Gene

RAD21-like 1 (S. pombe):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD21L1 Gene

No ASD Table

Relevant External Links for RAD21L1 Gene

GeneLoc Exon Structure for
RAD21L1
ECgene alternative splicing isoforms for
RAD21L1

Expression for RAD21L1 Gene

mRNA expression in normal human tissues for RAD21L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD21L1 Gene

This gene is overexpressed in Testis (46.1).

SOURCE GeneReport for Unigene cluster for RAD21L1 Gene Hs.713451

genes like me logo Genes that share expressions with RAD21L1: view

Orthologs for RAD21L1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD21L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD21L1 36
  • 99.58 (n)
  • 99.1 (a)
RAD21L1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD21L1 36
  • 90.09 (n)
  • 81.26 (a)
RAD21L1 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD21L1 36
  • 90.03 (n)
  • 84.86 (a)
RAD21L1 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad21l 36
  • 84.12 (n)
  • 73.91 (a)
Rad21l 16
Rad21l 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD21L1 37
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD21L1 37
  • 23 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad21l1 36
  • 82.25 (n)
  • 73.32 (a)
chicken
(Gallus gallus)
Aves RAD21L1 36
  • 62.75 (n)
  • 51.65 (a)
RAD21L1 37
  • 41 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD21L1 37
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rad21l1 37
  • 38 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta vtd 37
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea coh-1 36
  • 49.27 (n)
  • 36.8 (a)
coh-1 37
  • 22 (a)
ManyToMany
scc-1 37
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MCD1 39
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 41 (a)
OneToMany
Species with no ortholog for RAD21L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAD21L1 Gene

ENSEMBL:
Gene Tree for RAD21L1 (if available)
TreeFam:
Gene Tree for RAD21L1 (if available)

Paralogs for RAD21L1 Gene

Paralogs for RAD21L1 Gene

Selected SIMAP similar genes for RAD21L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with RAD21L1: view

Variants for RAD21L1 Gene

Sequence variations from dbSNP and Humsavar for RAD21L1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs203527 -- 1,246,138(-) AAATG(C/T)TTTAA intron-variant
rs203528 -- 1,250,260(-) aaaaa(G/T)aaaaa intron-variant
rs203529 -- 1,251,039(-) taaag(A/G)aagat intron-variant
rs203530 -- 1,251,720(-) gtcta(A/C/G/T)aagac intron-variant
rs203531 -- 1,238,836(-) aaaaa(A/T)aataa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD21L1 Gene

Variant ID Type Subtype PubMed ID
nsv912585 CNV Gain 21882294
nsv516776 CNV Loss 19592680
dgv4513n71 CNV Loss 21882294
nsv518957 CNV Gain 19592680

Relevant External Links for RAD21L1 Gene

HapMap Linkage Disequilibrium report
RAD21L1
Human Gene Mutation Database (HGMD)
RAD21L1

Disorders for RAD21L1 Gene

Relevant External Links for RAD21L1

Genetic Association Database (GAD)
RAD21L1
genes like me logo Genes that share disorders with RAD21L1: view

No data available for UniProtKB/Swiss-Prot for RAD21L1 Gene

Publications for RAD21L1 Gene

  1. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini S.E. … Oksenberg J.R. (Hum. Mol. Genet. 2009) 3 49
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification and molecular characterization of the mammalian ?- kleisin RAD21L. (PMID: 21527826) Gutierrez-Caballero C. … Pendas A.M. (Cell Cycle 2011) 3
  5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3

Products for RAD21L1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate RAD21L1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for RAD21L1
    • Block miRNA regulation of RAD21L1 using miScript Target Protectors

    Sources for RAD21L1 Gene

    Back to Top

    Content