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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

RAD21 Gene

protein-coding   GIFtS: 68
GCID: GC08M117858

RAD21 Homolog (S. Pombe)

(Previous name: RAD21 (S. pombe) homolog)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
RAD21 Homolog (S. Pombe)1 2     SCC12 5
NXP12 3 5     KIAA00783 5
Sister Chromatid Cohesion 11 2     RAD21 (S. Pombe) Homolog1
Nuclear Matrix Protein 12 3     CDLS42
HR212 3     HRAD212
NXP-12 3     MCD12
hHR212 3     Double-Strand-Break Repair Protein Rad21 Homolog2
SCC1 Homolog2 3     Protein Involved In DNA Double-Strand Break Repair2

External Ids:    HGNC: 98111   Entrez Gene: 58852   Ensembl: ENSG000001647547   OMIM: 6064625   UniProtKB: O602163   

Export aliases for RAD21 gene to outside databases

Previous GC identifers: GC08M116846 GC08M117919 GC08M117526 GC08M117814 GC08M117927 GC08M113184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for RAD21 Gene:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene
involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein
is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated
association of this protein with mitotic chromatin specifically at the centromere region suggests its role in
sister chromatid cohesion in mitotic cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for RAD21 Gene: 
RAD21 (RAD21 homolog (S. pombe)) is a protein-coding gene. Diseases associated with RAD21 include rad21-related cornelia de lange syndrome, and cornelia de lange syndrome, and among its related super-pathways are Mitotic Anaphase and Cohesin Loading onto Chromatin. GO annotations related to this gene include protein binding. An important paralog of this gene is RAD21L1.

UniProtKB/Swiss-Prot: RAD21_HUMAN, O60216
Function: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA
repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA
replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from
chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole
assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7
during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate
cytoplasmic events involved in the apoptotic pathway

Gene Wiki entry for RAD21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the RAD21 gene promoter:
         RFX1   FOXF2   Evi-1   PPAR-alpha   POU2F1   POU2F1a   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): RAD21 promoter sequence
   Search SABiosciences Chromatin IP Primers for RAD21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat RAD21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.11   HGNC cytogenetic band: 8q24.11

RAD21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
RAD21 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M117858:  view genomic region     (about GC identifiers)

Start:
117,858,173 bp from pter      End:
117,887,105 bp from pter
Size:
28,933 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RAD21_HUMAN, O60216 (See protein sequence)
Recommended Name: Double-strand-break repair protein rad21 homolog  
Size: 631 amino acids; 71690 Da
Subunit: Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge
domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in
a complex with SMC1A, SMC3, CDCA5, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5B and WAPAL; the interaction
is direct
Subcellular location: Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase
it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin
probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase,
it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome
separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm,
where it may trigger apoptosis
Sequence caution: Sequence=BAA07554.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K0E0 Q15001 Q99568

Explore the universe of human proteins at neXtProt for RAD21: NX_O60216

Explore proteomics data for RAD21 at MOPED 

Post-translational modifications:

  • UniProtKB: Cleaved by separase/ESPL1 at the onset of anaphase. Cleaved by caspase-3 and caspase-7 at the beginning of
    apoptosis. The cleavage by ESPL1 and caspase-3 take place at different sites
  • UniProtKB: Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from
    chromosome arms during prophase may be partly due to its phosphorylation by PLK
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60216

  • RAD21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    RAD21 Protein Expression
    REFSEQ proteins: NP_006256.1  
    ENSEMBL proteins: 
     ENSP00000297338   ENSP00000428513   ENSP00000430273   ENSP00000428003   ENSP00000429342  
     ENSP00000427923   ENSP00000430524   ENSP00000428158  
    Reactome Protein details: O60216
    Human Recombinant Protein Products for RAD21: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for RAD21
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    Novus Biologicals RAD21 Protein
    Novus Biologicals RAD21 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for RAD21 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000228nuclear chromosome ----
    GO:0000775chromosome, centromeric region TAS--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005694chromosome TAS--

    RAD21 for ontologies           About GeneDecksing



    RAD21 Antibody Products: 
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    Assay Products for RAD21: 
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    Cloud-Clone Corp. ELISAs for RAD21 
    Cloud-Clone Corp. CLIAs for RAD21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR023093 Rad21/Rec8_C
     IPR006909 Rad21/Rec8_C_eu
     IPR006910 Rad21_Rec8_N

    Graphical View of Domain Structure for InterPro Entry O60216

    ProtoNet protein and cluster: O60216

    UniProtKB/Swiss-Prot: RAD21_HUMAN, O60216
    Domain: The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3
    (By similarity)
    Similarity: Belongs to the rad21 family


    RAD21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RAD21_HUMAN, O60216
    Function: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA
    repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA
    replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can
    be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from
    chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole
    assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7
    during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate
    cytoplasmic events involved in the apoptotic pathway

         Genatlas biochemistry entry for RAD21:
    yeast (S pombe),RAD21 homolog,highly expressed in testis,thymus,involved in nucleotide excision repair of ionizing
    radiation induced DNA double-strand break

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12672959
         
    RAD21 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for RAD21:
     Decreased TP53 protein express  Increased ID2::GFP protein exp  Increased cell death in breast  Low eccentricity cells 
     Upregulation of Wnt/beta-caten 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Rad21):
     cellular  hematopoietic system  immune system  mortality/aging  reproductive system 

    RAD21 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for RAD21 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for RAD21

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for RAD21 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for RAD21 

    miRNA
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    hsa-miR-320a hsa-miR-16-2* hsa-miR-181c hsa-miR-25 hsa-let-7a-2* hsa-miR-511 hsa-let-7g* hsa-miR-18b*
    SwitchGear 3'UTR luciferase reporter plasmidRAD21 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for RAD21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for RAD21 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Cohesin Loading onto Chromatin
    Cohesin Loading onto Chromatin0.71
    Establishment of Sister Chromatid Cohesion0.62
    Mitotic Telophase/Cytokinesis0.71
    3Meiotic Synapsis
    Meiotic Synapsis0.70
    Chromosome Maintenance0.56
    Meiosis0.70
    4Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for RAD21
        Cell cycle Spindle assembly and chromosome separation


    3 Cell Signaling Technology (CST) Pathways for RAD21
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control
    DNA Damage

    1 GeneGo (Thomson Reuters) Pathway for RAD21
        Cell cycle Spindle assembly and chromosome separation

    5/16        Reactome Pathways for RAD21 (see all 16)
        Mitotic Metaphase and Anaphase
    Establishment of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Telophase/Cytokinesis


    1         Kegg Pathway  (Kegg details for RAD21):
        Cell cycle


    RAD21 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for RAD21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/680 Interacting proteins for RAD21 (O602161, 2, 3 ENSP000002973384) via UniProtKB, MINT, STRING, and/or I2D (see all 680)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMC3Q9UQE71, 2, 3, ENSP000003547204EBI-80739,EBI-80718 MINT-6178106 MINT-8081286 MINT-8385079 MINT-8081321 MINT-7914988 MINT-6178206 MINT-7945693 MINT-8080160 MINT-6178091 MINT-8081303 MINT-8385100 I2D: score=3 STRING: ENSP00000354720
    SSU72Q9NP772, 3, ENSP000002913864MINT-8081286 MINT-8081321 MINT-8081344 MINT-8081406 MINT-8081393 MINT-8080160 MINT-8081303 MINT-8081377 MINT-8080156 I2D: score=2 STRING: ENSP00000291386
    STAG2Q8N3U42, 3, ENSP000002180894MINT-6178106 MINT-8081286 MINT-8081321 MINT-7914988 MINT-8080160 MINT-8081377 I2D: score=9 STRING: ENSP00000218089
    STAG1Q8WVM72, 3, ENSP000003726894MINT-6178106 MINT-6178206 MINT-7945693 MINT-6178091 I2D: score=4 STRING: ENSP00000372689
    SMC2O953472, 3, ENSP000002863984MINT-7945693 I2D: score=2 STRING: ENSP00000286398
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0000910cytokinesis ----
    GO:0006302double-strand break repair TAS8812457
    GO:0006310DNA recombination TAS8812457
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA19468298

    RAD21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    RAD21 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for RAD21

    1 Novoseek inferred chemical compound relationship for RAD21 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycolipid 45 1 9820479 (1)

    Search CenterWatch for drugs/clinical trials and news about RAD21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for RAD21 gene: 
    NM_006265.2  

    Unigene Cluster for RAD21:

    RAD21 homolog (S. pombe)
    Hs.81848  [show with all ESTs]
    Unigene Representative Sequence: NM_006265
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000297338(uc003yod.3) ENST00000523986 ENST00000517749 ENST00000518055
    ENST00000520992 ENST00000517485 ENST00000523547 ENST00000519837 ENST00000522699
    ENST00000519469
    miRNA
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    hsa-miR-320a hsa-miR-16-2* hsa-miR-181c hsa-miR-25 hsa-let-7a-2* hsa-miR-511 hsa-let-7g* hsa-miR-18b*
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    Additional mRNA sequence: 

    AK097915.1 AK098521.1 AK125620.1 AK289505.1 BC001229.2 BC050381.1 D38551.1 X98294.1 

    24/29 DOTS entries (see all 29):

    DT.97771208  DT.100670854  DT.452774  DT.100670857  DT.92414550  DT.92412530  DT.92464093  DT.100670867 
    DT.95095804  DT.95168507  DT.121468904  DT.100670863  DT.95325953  DT.95168515  DT.121468959  DT.100670866 
    DT.121468905  DT.91952378  DT.100723214  DT.121468816  DT.92393545  DT.95083595  DT.100044821  DT.121468853 

    24/837 AceView cDNA sequences (see all 837):

    BE280597 BM743240 BG568532 BP359221 D38551 BM920285 CB120533 CB151203 
    AW151514 AW163750 BM722029 CB146733 BU509303 BM755592 BM768050 AU136716 
    AW274985 BM818927 BM739843 AI124620 BM679660 N68822 BU507521 BG284596 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for RAD21 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^
    SP1:        -     -     -     -     -     -                                                                                         -     -                     
    SP2:                          -     -     -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:              -     -     -     -     -                       -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:              -     -     -     -     -                                                                                                                     

    ExUns: 16a · 16b ^ 17a · 17b · 17c
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:  -                           
    SP5:                              


    ECgene alternative splicing isoforms for RAD21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    RAD21 expression in normal human tissues (normalized intensities)      RAD21 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACTGTTAT
    RAD21 Expression
    About this image


    RAD21 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/39 selected tissues (see all 39) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
             brain/midbrain   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See RAD21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for RAD21

    SOURCE GeneReport for Unigene cluster: Hs.81848
        SABiosciences Expression via Pathway-Focused PCR Arrays including RAD21: 
              Cell Cycle in human mouse rat
              TGFB Signaling Targets in human mouse rat
              DNA Damage Signaling Pathway in human mouse rat
              DNA Repair in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for RAD21 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Rad211 , 5 RAD21 homolog (S. pombe)1, 5 87.8(n)1
    97.31(a)1
      15 (19.54 cM)5
    193571  NM_009009.41  NP_033035.31 
     519626055 
    chicken
    (Gallus gallus)
    Aves RAD211 RAD21 homolog (S. pombe) 83.02(n)
    93.49(a)
      420286  NM_001030950.1  NP_001026121.1 
    lizard
    (Anolis carolinensis)
    Reptilia RAD216
    Uncharacterized protein
    92(a)
    1 ↔ 1
    4(7050808-7082307)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.60462 Xenopus laevis 14S cohesin RAD21 subunit mRNA, complete more 79.75(n)    AF051786.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rad212 RAD21 homolog (S. pombe) 76.37(n)   322275  BC045311.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Rad213
    vtd1
    mitotic sister chromatid cohesion3
    verthandi1
    37(a)3
    52.28(n)1
    46.71(a)1
      33548961  NM_001015132.11  NP_001015132.11 
    worm
    (Caenorhabditis elegans)
    Secernentea coh-11 , 3 S. pombe double-strand-break repair
    protein, RAD213
    Protein COH-11
    34(a)
    (best of 2)3
    46.76(n)1
    36.22(a)1
      1810031  NM_076861.21  NP_509262.11 


    ENSEMBL Gene Tree for RAD21 (if available)
    TreeFam Gene Tree for RAD21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for RAD21 gene
    RAD21L12  
    2 SIMAP similar genes for RAD21 using alignment to 8 protein entries:     RAD21_HUMAN (see all proteins):
    RAD21L    RAD21L1

    RAD21 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for RAD21
    PGOHUM00000241906


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: RAD21_HUMAN, O60216
    Polymorphism: Some radiosensitive cancer patients seem to have Arg-481 instead of the conserved Gly-481. It may be
    that this mutation could contribute to radiosensitivity


    10/776 SNPs in RAD21 are shown (see all 776)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0686914
    Cornelia de Lange syndrome 4 (CDLS4)4--see VAR_0686912 P R mis40--------
    VAR_0686924
    Cornelia de Lange syndrome 4 (CDLS4)4--see VAR_0686922 C R mis40--------
    VAR_0142814
    ----see VAR_0142812 G R mis40--------
    rs168939921,2
    C,F--113196270(-) GAATTAAAGTT/-
            
    TAAAC
    1 -- int11Minor allele frequency- -:0.17NS 170
    rs676801231,2
    C--117861000(+) TAATA-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs168939901,2
    C,F--117862202(-) ATCGGAT/-ATGTT 1 -- int11Minor allele frequency- -:0.01NS 166
    rs1506119141,2
    C--117863366(+) TAATA-/AA    
       T
    /ATA
    GGAGT
    2 -- cds10--------
    rs340004221,2
    C--117867947(+) TTTTT-/TAAAAA 1 -- int10--------
    rs355461271,2
    C--117868237(+) AGAAG-/CCTAGT 1 -- int10--------
    rs583762511,2
    C--117868824(+) ATGGT-/TAAGTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for RAD21 (117858173 - 117887105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for RAD21:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6359CNV Insertion18451855
    esv271630CNV Insertion20981092
    dgv7871n71CNV Loss21882294
    nsv831434CNV Gain17160897


    Human Gene Mutation Database (HGMD): RAD21
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing RAD21
    DNA2.0 Custom Variant and Variant Library Synthesis for RAD21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606462    OMIM disorders: --

    UniProtKB/Swiss-Prot: RAD21_HUMAN, O60216
  • Cornelia de Lange syndrome 4 (CDLS4) [MIM:614701]: A form of Cornelia de Lange syndrome, a clinically
    heterogeneous developmental disorder associated with malformations affecting multiple systems. It is
    characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism,
    gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. Note=The disease is caused
    by mutations affecting the gene represented in this entry

  • 19 diseases for RAD21:    About MalaCards
    rad21-related cornelia de lange syndrome    cornelia de lange syndrome    roberts syndrome    langer-giedion syndrome
    kaposi's sarcoma    fanconi's anemia    oral squamous cell carcinoma    anemia
    chronic lymphocytic leukemia    sarcoma    schizophrenia    squamous cell carcinoma
    pancreatic cancer    hypoxia    pancreatitis    leukemia
    prostate cancer    prostatitis    breast cancer

    2 diseases from the University of Copenhagen DISEASES database for RAD21:
    Cornelia de Lange syndrome     Roberts syndrome

    RAD21 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for RAD21 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 3 11483345 (2), 15767545 (1)

    Genetic Association Database (GAD): RAD21
    Human Genome Epidemiology (HuGE) Navigator: RAD21 (4 documents)

    Export disorders for RAD21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for RAD21 gene, integrated from 9 sources (see all 105):
    (articles sorted by number of sources associating them with RAD21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. (PubMed id 8812457)1, 2, 3 McKay M.J.... Hoeijmakers J.H.J. (1996)
    2. Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. (PubMed id 11073952)1, 2, 9 Hoque M.T. and Ishikawa F. (2001)
    3. Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. (PubMed id 11483345)1, 2, 9 Severin D.M.... McKay M. (2001)
    4. Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. (PubMed id 11509732)1, 2, 9 Hauf S.... Peters J.-M. (2001)
    5. RAD21 mutations cause a human cohesinopathy. (PubMed id 22633399)1, 2 Deardorff M.A....Kaiser F.J. (2012)
    6. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PubMed id 19074885)1, 4 Enjuanes A....Campo E. (2008)
    7. Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. (PubMed id 18829510)1, 4 Azria D....Rosenstein B.S. (2008)
    8. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. (PubMed id 15837422)1, 2 Rankin S.... Kirschner M.W. (2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5885 HGNC: 9811 AceView: RAD21 Ensembl:ENSG00000164754 euGenes: HUgn5885
    ECgene: RAD21 Kegg: 5885 H-InvDB: RAD21

    (According to HUGE)
    About This Section
    HUGE: KIAA0078

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for RAD21 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for RAD21 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/rad21/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for RAD21 gene:
    Search GeneIP for patents involving RAD21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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